@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2751: (2016-04-06 )
MKVLFHHLKKYKLQATLSTLFVVVMVISQLWQPKLLQQVLDAIMKDDMDEISSIGALLIGIAAVGLIAGILNTILSAKVAQGVGADIRESSFRKIQTFSFSNIEKLSTGNLVVRQTNDITQVQNLVMLSLQSLTRIPIMFIGAFILAMFTLPELWWVIIVLVVLVVLIVVFTFGSMGKHFAIIQKLIDRVNSIAKENLAGMRVVKSFVQEDNEIGRFTTVSDKLTRHTIIVGTLFSVMIPAFMLVSNLAIVVSIFFVGDMAADNPEVIGAIASFMNYLMQIMMAIIIGGMLMMMASRALISLKRITEVLETEPDITYNENAPEQDLEGTVEFRNVSFKYDGDDTPALEDISFKASVGEMVGIVGATGSGKSTLAQLIPRLYDPTEGEVIIGGTNLKDINKKTLRSTVSFVLQRAILFSGTIADNLRHGKKDATAEEMEHASKIAQAKEFIDKQAKLYEAPVSERGNNFSGGQKQRLSITRGVIGSPKVLILDDSTSALDAKSEKLVKEALNKELDDTTTFIIAQKISSVIQADKILVLDKGKLVGVGSHKELLKENETYREIYDTQKGKEVTA
Atome Classification :
(53 SA)
------------------------------------------------------------------------------.........10..-......20........30........40-..-...-.---.---.50........60........70...---.....80........90........100.......110.......120.----......130.......140.......150.......160...------....170.......180....-...190.......200.......210.....----..220---.......230.......240.......250......-.260.....-..270.......280.......290...------------.-----...300.......310.......320---.--....--..--..330.......-340-.-.......350.......360.......370.......380..---.....390...--..--..400.......410.......-420-...--------...-.-430--.---....-...440-........450---.......460.......470.......480.......490.......500......-.510.--...--.....520.......530........540.......550.--..--....560.......570.--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------MK
V
L
F
H
H
L
K
K
Y
K
L
-
Q
A
T
L
S
T
L
F
V
V
V
M
V
I
S
Q
LW
Q
P
K
L
L
Q
Q
V
L
D
-
A
I
-
M
KD-
D
---
M
---
D
E
I
S
S
I
G
A
L
L
I
G
I
A
A
V
G
L
I
A
G
I
L
N
T
I
---
L
S
A
K
V
A
Q
GVGA
D
I
R
E
S
S
F
R
K
I
Q
T
FSFSN
I
E
KLSTG
N
L
V
V
R
QTN
D
I
T
Q
V
Q
----
N
L
V
M
L
S
L
Q
S
L
TR
I
P
I
M
F
I
G
A
F
I
L
A
M
F
T
L
P
E
L
W
W
V
I
I
V
L
V
V
L
V
------
V
L
I
V
V
F
T
FGSMG
K
H
F
A
I
I
Q
K
L
-
I
D
R
V
N
S
I
A
K
E
NL
A
G
M
R
V
V
K
S
F
V
Q
EDNEIG
R
F
----TTVSD---KLTRH
T
I
I
V
G
T
L
F
S
V
M
I
P
A
F
M
L
V
S
N
L
A
I
V
V
S
I
F
F
VG-DMAAD
N
P
E
V
-
I
G
A
I
A
S
F
M
N
Y
L
M
Q
I
M
M
A
I
I
I
G
G
M
L
M
M
M
A
------------
S
-----
R
A
L
I
S
L
K
R
I
T
E
V
L
ETEPDITYNEN-----A--
P
E
Q
D--LE--G
T
V
E
F
R
N
V
S
F
K
Y-D-G-D-DTPALEDISFKASVG
E
M
V
G
I
VGATGS
G
K
S
T
L
A
Q
L
I
P
R
LYDPT---EG
E
V
I
IGGT
N
L
--
K
D
--
I
N
K
K
T
L
R
S
T
V
S
F
V
L
Q
R
A
I
L
FSG-
T
I
A
-
D
N
L--------RHG-K-KD---A---
T
A
E
E
-
M
E
H
A
S
--
K
I
A
Q
A
K
E
F
I
D
K
---
Q
A
K
L
YEA
P
V
S
ERGNNFSGG
Q
K
Q
R
L
S
I
TRGVIGS
P
K
V
L
I
LDDSTSAL
D
A
K
S
E
K
L
V
K
E
-
A
L
--
N
--KEL--DD
T
T
T
F
I
I
A
Q
K
I
S
S
V
I
Q-A
D
K
I
L
V
L
DKG
K
L
V
GVG
S
H
K
E
L
L
--KE--N
E
T
Y
R
E
I
Y
DTQKGKEVTA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.13
41%
-109
- C2 -
3QF4
2
?
A:
[12-579]
-------------------------------------------------------------------------------
K
T
L
A
R
Y
L
K
P
Y
W
I
-
F
A
V
L
A
P
L
F
M
V
V
E
V
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L
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Q
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L
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-
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-
D
---
F
---
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G
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C
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---
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A
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N
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R
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V
N
R
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H
T
S
S
L
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R
L
T
N
D
V
T
Q
L
Q
----
N
L
V
M
M
L
L
R
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V
V
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L
L
F
V
G
G
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M
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V
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K
L
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S
V
L
I
F
L
I
P
P
I
------
V
L
L
F
V
W
L
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K
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N
P
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F
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S
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V
N
R
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N
L
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V
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V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
----
R
K
A
N
E
---
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L
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R
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I
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S
L
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A
L
P
L
F
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F
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N
M
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M
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V
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G
-
V
L
V
R
N
N
Q
M
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-
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G
S
I
M
A
Y
T
N
Y
L
M
Q
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M
F
S
L
M
M
I
G
N
I
L
N
F
I
------------
V
-----
R
A
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A
S
A
K
R
V
L
E
V
L
N
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K
P
A
I
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A
D
N
-----
A
L
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A
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--
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--
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N
V
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---
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R
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K
L
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G
H
I
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P
Q
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T
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F
S
G
-
T
I
K
-
E
N
L
--------
K
W
G
-
R
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D
---
A
---
T
D
D
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-
I
V
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A
A
--
K
I
A
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D
F
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---
L
P
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R
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-
G
L
--
K
--
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Y
T
--
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
--
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.55
41%
-108
- C2 -
4Q4A
2
?
A:
[12-579]
-------------------------------------------------------------------------------
K
T
L
A
R
Y
L
K
P
Y
W
I
-
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
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G
I
-
A
R
G
-
D
---
F
---
S
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
---
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
----
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
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K
L
S
S
V
L
I
F
L
I
P
P
I
------
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
-
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
----
R
K
A
N
E
---
S
L
R
R
S
I
I
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A
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S
L
I
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L
P
L
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N
M
G
M
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A
V
L
W
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G
G
-
V
L
V
R
N
N
Q
M
E
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I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
------------
V
-----
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
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E
A
D
N
-----
A
L
-
A
L
P
N
--
V
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--
G
S
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F
E
N
V
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F
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F
-
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-
T
D
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V
N
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V
L
G
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S
G
K
S
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N
L
I
P
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I
D
P
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---
R
G
R
V
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L
D
V
--
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V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
-
E
N
L
--------
K
W
G
-
R
-
E
D
---
A
---
T
D
D
E
-
I
V
E
A
A
--
K
I
A
Q
I
H
D
F
I
I
S
---
L
P
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R
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L
--
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T
T
F
I
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K
I
P
T
A
L
L
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A
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L
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A
G
F
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L
L
--
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.53
41%
-104
- C2 -
4Q4J
-
?
A:
[12-579]
-------------------------------------------------------------------------------
K
T
L
A
R
Y
L
K
P
Y
W
I
-
F
A
V
L
A
P
L
F
M
V
V
E
V
I
S
D
L
S
Q
P
T
L
L
A
R
I
V
D
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G
I
-
A
R
G
-
D
---
F
---
S
L
V
L
K
T
G
I
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M
L
I
V
A
L
I
G
A
V
G
G
I
G
S
T
V
---
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
----
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
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K
L
S
S
V
L
I
F
L
I
P
P
I
------
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
-
T
D
E
V
N
R
V
V
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N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
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N
E
N
F
----
R
K
A
N
E
---
S
L
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S
I
I
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L
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M
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V
L
W
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G
-
V
L
V
R
N
N
Q
M
E
-
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
------------
V
-----
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
-----
A
L
-
A
L
P
N
--
V
E
--
G
S
V
S
F
E
N
V
E
F
R
Y
-
F
-
E
-
N
-
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
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L
D
V
--
R
T
--
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K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
-
E
N
L
--------
K
W
G
-
R
-
E
D
---
A
---
T
D
D
E
-
I
V
E
A
A
--
K
I
A
Q
I
H
D
F
I
I
S
---
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
S
T
C
S
V
D
P
I
T
E
K
R
I
L
D
-
G
L
--
K
--
R
Y
T
--
K
G
S
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
--
E
H
--
S
K
P
Y
R
E
I
Y
E
S
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.70
41%
-106
- C2 -
4Q4H
-
?
A:
[12-579]
-------------------------------------------------------------------------------
K
T
L
A
R
Y
L
K
P
Y
W
I
-
F
A
V
L
A
P
L
F
M
V
V
E
V
I
C
D
L
S
Q
P
T
L
L
A
R
I
V
D
E
G
I
-
A
R
G
-
D
---
F
---
S
L
V
L
K
T
G
I
L
M
L
I
V
A
L
I
G
A
V
G
G
I
G
C
T
V
---
F
A
S
Y
A
S
Q
N
F
G
A
D
L
R
R
D
L
F
R
K
V
L
S
F
S
I
S
N
V
N
R
F
H
T
S
S
L
I
T
R
L
T
N
D
V
T
Q
L
Q
----
N
L
V
M
M
L
L
R
I
V
V
R
A
P
L
L
F
V
G
G
I
V
M
A
V
S
I
N
V
K
L
S
S
V
L
I
F
L
I
P
P
I
------
V
L
L
F
V
W
L
T
K
K
G
N
P
L
F
R
K
I
Q
E
S
-
T
D
E
V
N
R
V
V
R
E
N
L
L
G
V
R
V
V
R
A
F
R
R
E
E
Y
E
N
E
N
F
----
R
K
A
N
E
---
S
L
R
R
S
I
I
S
A
F
S
L
I
V
F
A
L
P
L
F
I
F
I
V
N
M
G
M
I
A
V
L
W
F
G
G
-
V
L
V
R
N
N
Q
M
E
-
I
G
S
I
M
A
Y
T
N
Y
L
M
Q
I
M
F
S
L
M
M
I
G
N
I
L
N
F
I
------------
V
-----
R
A
S
A
S
A
K
R
V
L
E
V
L
N
E
K
P
A
I
E
E
A
D
N
-----
A
L
-
A
L
P
N
--
V
E
--
G
S
V
S
F
E
N
V
E
F
R
Y
-
F
-
E
-
N
-
T
D
P
V
L
S
G
V
N
F
S
V
K
P
G
S
L
V
A
V
L
G
E
T
G
S
G
K
S
T
L
M
N
L
I
P
R
L
I
D
P
E
---
R
G
R
V
E
V
D
E
L
D
V
--
R
T
--
V
K
L
K
D
L
R
G
H
I
S
A
V
P
Q
E
T
V
L
F
S
G
-
T
I
K
-
E
N
L
--------
K
W
G
-
R
-
E
D
---
A
---
T
D
D
E
-
I
V
E
A
A
--
K
I
A
Q
I
H
D
F
I
I
S
---
L
P
E
G
Y
D
S
R
V
E
R
G
G
R
N
F
S
G
G
Q
K
Q
R
L
S
I
A
R
A
L
V
K
K
P
K
V
L
I
L
D
D
C
T
S
S
V
D
P
I
T
E
K
R
I
L
D
-
G
L
--
K
--
R
Y
T
--
K
G
C
T
T
F
I
I
T
Q
K
I
P
T
A
L
L
-
A
D
K
I
L
V
L
H
E
G
K
V
A
G
F
G
T
H
K
E
L
L
--
E
H
--
C
K
P
Y
R
E
I
Y
E
S
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
73.67
27%
-100
- C2 -
3WMG
6
?
A:
[16-598]
--------------------------------------------------------------------------------
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
-
V
F
-
T
K
S
-
K
S
Q
I
E
---
G
E
T
W
K
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
---
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
----
Y
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
------
V
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
-
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
----
G
S
K
L
D
---
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
-
Q
L
I
A
R
G
S
L
N
-
L
G
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
------------
T
-----
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
V
P
Q
Y
R
R
P
D
P
G
A
E
V
V
T
--
Q
P
L
V
--
L
K
--
Q
G
I
V
F
E
N
V
H
F
R
Y
-
P
-
T
-
R
M
N
V
E
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
--
W
N
--
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
-
T
I
R
-
D
N
I
--------
L
Y
G
-
K
-
R
D
---
A
---
T
D
E
E
-
V
I
Q
A
L
--
R
E
A
N
A
Y
S
F
V
M
A
---
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
-
A
L
--
D
--
R
M
M
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
-
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
--
A
L
GP
S
G
F
Y
Y
Q
L
V
E
K
Q
L
A
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Fugue
72.65
27%
-97
- C2 -
3B60
2
MSBA_SALTY
A:
[10-581]
---------------------------------------------------------------------------W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
-
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
-
G
K
T
-
D
---
R
---
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
---
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
----
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
------
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
-
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
----
D
K
V
S
N
---
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
-
F
P
S
V
M
D
S
L
T
-
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
------------
Q
-----
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
-
E
G
K
-----
R
--
V
I
D
R
--
A
T
--
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
-
G
-
R
-
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
--
R
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
-
N
N
I
--------
A
Y
A
-
R
-
T
E
---
E
Y--
S
R
E
Q
-
I
E
E
A
A
--
R
M
A
Y
A
M
D
F
I
N
K
---
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
-
A
L
--
D
--
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
--
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
HHSearch
71.54
27%
-95
- C2 -
3B60
2
MSBA_SALTY
A:
[16-581]
---------------------------------------------------------------------------------
L
W
P
T
I
A
P
F
K
A
-
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
-
D
G
F
G
K
T
-
D
---
R
---
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
---
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
----
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
------
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
-
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
----
D
K
V
S
N
---
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
-
F
P
S
V
M
D
S
L
T
-
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
------------
Q
-----
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
R
--------
V
I
D
R
--
A
T
--
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
-
G
-
R
-
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
--
R
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
-
N
N
I
--------
A
Y
A
-
R
-
T
E
E--
Y
---
S
R
E
Q
-
I
E
E
A
A
--
R
M
A
Y
A
M
D
F
I
N
K
---
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
-
A
L
--
D
--
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
--
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
HHSearch
71.20
28%
-100
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[7-572]
------------------------------------------------------------------------------
A
R
K
L
L
G
L
A
Y
P
E
R
R
-
R
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
-
V
I
-
Y
T
N
P
T
---
V
DY
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
---
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
----
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
------
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
-
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----
A
S
K
V
D
---
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
-
L
L
M
G
S
A
H
M
T
-
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
------------
M
-----
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
-----
V
I
L
N
E
K
S
--
F
Q
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
-
A
-
R
P
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
--
R
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
-
E
N
I
--------
A
Y
G
-
A
-
D
D
PSS
V
---
T
A
E
E
-
I
Q
R
V
A
--
E
V
A
N
A
V
A
F
I
R
N
---
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
-
A
L
--
D
--
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
--
S
K
P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
69.61
31%
-101
- C2 -
4AYX
7
ABCBA_HUMAN
A:
[27-574]
---------------------------------------------------------------------------------------------------
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
-
V
I
-
Y
T
N
-
P
T--
V
---
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
----
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
------
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
-
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
---
F
G
A
T
G
L
S
G
N
L
-
I
V
L
S
V
L
Y
K
G
-
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
--
G
I
S
I
G
G
L
S
S
F
Y
S
------------
E
L
M
---
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
-----
V
I
L
N
E
K
S
--
F
Q
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
-
A
R
P
-
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
--
R
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
-
E
N
I
--------
A
Y
G
-
A
-
D
D
---
P
SSV
T
A
E
E
-
I
Q
R
V
A
--
E
V
A
N
A
V
A
F
I
R
N
---
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
-
A
L
--
D
--
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
-
K
P
--
N
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.92
31%
-99
- C2 -
3ZDQ
6
ABCBA_HUMAN
A:
[27-572]
---------------------------------------------------------------------------------------------------
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
-
V
I
-
Y
T
N
-
P
T--
V
---
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
----
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
------
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
-
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
---
F
G
A
T
G
L
S
G
N
L
-
I
V
L
S
V
L
Y
K
G
-
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
--
G
I
S
I
G
G
L
S
S
F
Y
S
------------
E
L
M
---
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
-----
V
I
L
N
E
K
S
--
F
Q
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
-
A
R
P
-
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
--
R
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
-
E
N
I
--------
A
Y
G
-
A
-
D
D
---
P
SSV
T
A
E
E
-
I
Q
R
V
A
--
E
V
A
N
A
V
A
F
I
R
N
---
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
-
A
L
--
D
--
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
-
K
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
68.30
32%
-94
- C2 -
2ONJ
4
Y1866_STAAM
B:
[95-577]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
----
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
------
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
-
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
DKKN
T
N
F
L
T
---
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
----
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
-
Y
L
A
I
S
G
S
I
T
-
V
G
T
L
A
A
F
V
G
Y
L
-----
E
L
L
F
G
P
L
R
R
L
V
A
------------
S
FTTLT
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
-----
A
Q-
P
I
E
I
--
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
-
D
-
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
--
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
-
E
N
I
--------
L
L
G
-
R
-
P
T
---
A
---
T
D
E
E
-
V
V
E
A
A
--
K
M
A
N
A
H
D
F
I
M
N
---
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
-
A
L
--
D
--
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
--
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
67.98
31%
-102
- C2 -
4AYW
3
ABCBA_HUMAN
A:
[58-598]
---------------------------------------------------------------------------------------------------
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
-
V
I
-
Y
T
N
-
P
T--
V
---
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
----
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
------
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
-
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
---
F
G
A
T
G
L
S
G
N
L
-
I
V
L
S
V
L
Y
K
G
-
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
--
G
I
S
I
G
G
L
S
S
F
Y
S
------------
E
L
M
---
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
-----
V
I
L
N
E
K
S
--
F
Q
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
-
A
R
P
-
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
--
R
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
-
E
N
I
--------
A
Y
G
-
A
-
D
D
---
P
SSV
T
A
E
E
-
I
Q
R
V
A
--
E
V
A
N
A
V
A
F
I
R
N
---
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
-
A
L
--
D
--
R
L
M
--
D
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
67.52
32%
-93
- C2 -
2HYD
3
Y1866_STAAM
B:
[95-577]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
----
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
------
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
-
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
DKKN
T
N
F
L
T
---
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
----
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
-
Y
L
A
I
S
G
S
I
T
-
V
G
T
L
A
A
F
V
G
Y
L
-----
E
L
L
F
G
P
L
R
R
L
V
A
------------
S
FTTLT
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
-----
A
Q-
P
I
E
I
--
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
-
D
-
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
--
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
-
E
N
I
--------
L
L
G
-
R
-
P
T
---
A
---
T
D
E
E
-
V
V
E
A
A
--
K
M
A
N
A
H
D
F
I
M
N
---
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
-
A
L
--
D
--
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
--
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
67.32
32%
-92
- C2 -
2HYD
3
Y1866_STAAM
A:
[95-577]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
----
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
------
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
-
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
---
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
----
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
-
Y
L
A
I
S
G
S
I
T
-
V
G
T
L
A
A
F
V
G
Y
L
-----
E
L
L
F
G
P
L
R
R
L
V
A
------------
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
-----
A
Q-
P
I
E
I
--
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
-
D
-
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
--
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
-
E
N
I
--------
L
L
G
-
R
-
P
T
---
A
---
T
D
E
E
-
V
V
E
A
A
--
K
M
A
N
A
H
D
F
I
M
N
---
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
-
A
L
--
D
--
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
--
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
67.04
31%
-98
- C2 -
4AYT
8
ABCBA_HUMAN
A:
[27-567]
---------------------------------------------------------------------------------------------------
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
-
V
I
-
Y
T
N
-
P
T--
V
---
D
Y
S
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
----
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
------
S
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
-
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
----
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
R
A
G
F
---
F
G
A
T
G
L
S
G
N
L
-
I
V
L
S
V
L
Y
K
G
-
G
L
L
M
G
S
A
H
M
T
V
G
E
L
S
S
F
L
M
Y
A
F
W
V
--
G
I
S
I
G
G
L
S
S
F
Y
S
------------
E
L
M
---
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
E
P
K
L
P
F
N
E
G
-----
V
I
L
N
E
K
S
--
F
Q
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
-
A
R
P
-
E
V
P
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
--
R
Q
--
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
-
S
I
A
-
E
N
I
--------
A
Y
G
-
A
-
D
D
---
P
SSV
T
A
E
E
-
I
Q
R
V
A
--
E
V
A
N
A
V
A
F
I
R
N
---
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
-
A
L
--
D
--
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
67.04
32%
-93
- C2 -
2ONJ
4
Y1866_STAAM
A:
[95-577]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
----
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
------
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
-
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
---
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
----
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
-
Y
L
A
I
S
G
S
I
T
-
V
G
T
L
A
A
F
V
G
Y
L
-----
E
L
L
F
G
P
L
R
R
L
V
A
------------
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
-----
A
Q-
P
I
E
I
--
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
-
D
-
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
--
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
-
E
N
I
--------
L
L
G
-
R
-
P
T
---
A
---
T
D
E
E
-
V
V
E
A
A
--
K
M
A
N
A
H
D
F
I
M
N
---
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
-
A
L
--
D
--
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
--
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.95
28%
-87
- C2 -
3B60
2
MSBA_SALTY
A:
[14-581]
-------------------------------------------------------------------------------
R
R
L
W
P
T
I
A
P
F
K
A
-
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
-
G
K
T
-
D
---
R
---
S
V
L
L
W
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
---
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
----
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
-
M
F
Y
Y
S
--
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
---
M
Q
N
T
-
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
----
D
K
V
S
N
---
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
------
A
A
S
F
P
S
V
--------
M
D
S
L
T
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
-----
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
E
Q
E
K
D
E
G
K
R
-----
V
--
I
D
R
---
A
T
--
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
-
G
-
R
-
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
--
R
E
--
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
-
T
V
A
-
N
N
I
--------
A
Y
A
-
R
T
E
E
---
Y
---
S
R
E
Q
-
I
E
E
A
A
--
R
M
A
Y
A
M
D
F
I
N
K
---
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
-
A
L
--
D
--
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
--
A
Q
--
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
66.38
29%
-94
- C2 -
4F4C
-
PGP1_CAEEL
A:
[134-703]
------------------------------------------------------------------------------------------------------------------------------
D
-
V
---
M
---
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
----
A
G
Q
I
T
V
T
---
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
----
F
I
T
G
F
I
V
A
-
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
------
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
----
S
T
A
V
E
---
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
-
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
G
S
L
N
-
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
------------
G
-----
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
P
V
I
D
S
S
S
K
-----
A
--
G
R
K
D
--
M
K
IK
G
D
I
T
V
E
N
V
H
F
T
Y
-
P
-
S
R
P
-
D
V
P
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
D
V
--
R
D
--
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
-
T
I
E
-
E
N
I
--------
S
L
G
-
K
-
E
G
---
I
---
T
R
E
E
-
M
V
A
A
C
--
K
M
A
N
A
E
K
F
I
K
T
---
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
-
A
L
--
D
--
K
A
A
--
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
-
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
--
A
Q
--
Q
G
L
Y
Y
D
L
V
T
A
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Fugue
62.71
25%
-96
- C2 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
-
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
L
P
T
G
Q
N
-
Y
T
-
K
T
D
-
F
---
E
---
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
---
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
----
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
------
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
-
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
----
S
T
A
V
E
---
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
-
G
W
V
H
D
G
S
L
N
-
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
------------
G
-----
T
A
Q
G
A
A
S
G
I
Y
E
V
L
D
R
K
P
V
I
D
S
S
S
K
-----
A
--
G
R
K
D
MK
I
K
--
G
D
I
T
V
E
N
V
H
F
T
Y
P
S
-
R
-
P
-
D
V
P
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
---
K
G
K
I
T
I
D
G
V
D
V
--
R
D
--
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
-
T
I
E
-
E
N
I
--------
S
L
G
-
K
-
E
G
---
I
---
T
R
E
E
-
M
V
A
A
C
--
K
M
A
N
A
E
K
F
I
K
T
---
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
-
A
L
--
D
--
K
A
A
--
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
-
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
--
A
Q
--
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
7
PsiBlast_PDB
56.25
32%
-91
- C2 -
4A82
-
Y1866_STAAM
A:
[95-577]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
----
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
------
I
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
-
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
---
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
----
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
-
Y
L
A
I
S
G
S
I
T
-
V
G
T
L
A
A
F
V
G
Y
L
-----
E
L
L
F
G
P
L
R
R
L
V
A
------------
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
D
Y
D
I
K
N
G
V
G
-----
A
Q-
P
I
E
I
--
K
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
-
D
-
N
-
E
A
P
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
--
K
D
--
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
-
T
V
K
-
E
N
I
--------
L
L
G
-
R
-
P
T
---
A
---
T
D
E
E
-
V
V
E
A
A
--
K
M
A
N
A
H
D
F
I
M
N
---
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
-
A
L
--
D
--
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
--
A
K
--
Q
G
A
Y
E
H
L
Y
S
I
Q
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
52.84
41%
-71
- C2 -
2FF7
1
A:
[6-245]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
D
I
T
F
R
N
I
R
F
R
Y
-
K
-
P
-
D
-
S
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
--
A
L
--
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
-
D
N
I
--------
S
L
A
-
N
-
P
G
---
M
---
S
V
E
K
-
V
I
Y
A
A
--
K
L
A
G
A
H
D
F
I
S
E
---
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
-
N
M
--
H
--
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
--
S
E
P-
E
S
L
Y
S
Y
L
Y
Q
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
50.90
33%
-74
- C2 -
2IXE
3
D:
[12-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
M
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
-
H
-
P
-
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
--
P
L
L
F
G
R
-
S
F
R
-
E
N
I
--------
A
Y
G
L
T
-
R
T
---
P
---
T
M
E
E
-
I
T
A
V
A
--
M
E
S
G
A
H
D
F
I
S
G
---
F
P
Q
G
Y
D
T
E
V
-----
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
YE
S
--
P
E
W
--
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
--
E
R
--
G
G
C
Y
R
S
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
50.55
33%
-71
- C2 -
2IXF
4
TAP1_RAT
C:
[12-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
M
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
-
H
-
P
-
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
-
E
N
I
--------
A
Y
G
L
T
-
R
T
---
P
---
T
M
E
E
-
I
T
A
V
A
--
M
E
S
G
A
H
D
F
I
S
G
---
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
YE
S
--
P
E
W
--
A
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
--
E
R
--
G
G
C
Y
R
S
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
50.39
33%
-68
- C2 -
2IXG
2
A:
[12-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
M
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
-
H
-
P
-
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
-
E
N
I
--------
A
Y
G
L
T
-
R
T
---
P
---
T
M
E
E
-
I
T
A
V
A
--
M
E
S
G
A
H
D
F
I
S
G
---
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
A
V
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
Y
E
S
--
P
E
W
--
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
--
E
R
--
G
G
C
Y
R
S
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
50.35
33%
-73
- C2 -
4K8O
4
A:
[12-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
M
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
-
H
-
P
-
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
-
E
N
I
--------
A
Y
G
L
T
-
R
T
---
P
---
T
M
E
E
-
I
T
A
V
A
--
M
E
S
G
A
H
D
F
I
S
G
---
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
A
A
G
N
Q
L
R
V
Q
R
-
L
L
YE
S
--
P
E
W
--
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
--
E
R
--
G
G
C
Y
R
S
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
49.57
33%
-63
- C2 -
2IXE
4
TAP1_RAT
A:
[13-256]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
-
N
-
H
P
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
-
E
N
I
--------
A
Y
G
-
L
-
T
R
---
T
P
--
T
M
E
E
-
I
T
A
V
A
--
M
E
S
G
A
H
D
F
I
S
G
---
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
--
Y
--
E
S
P
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
--
E
R
--
G
G
C
Y
R
S
M
V
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
49.33
33%
-69
- C2 -
2IXF
5
TAP1_RAT
A:
[12-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
M
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
-
H
-
P
-
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
-
E
N
I
--------
A
Y
G
L
T
-
R
T
---
P
---
T
M
E
E
-
I
T
A
V
A
--
M
E
S
G
A
H
D
F
I
S
G
---
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
Y
E
S
--
P
E
W
--
A
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
--
E
R
--
G
G
C
Y
R
S
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
49.26
33%
-66
- C2 -
2IXE
4
TAP1_RAT
A:
[12-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
M
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
-
H
-
P
-
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
-
E
N
I
--------
A
Y
G
L
T
-
R
T
---
P
---
T
M
E
E
-
I
T
A
V
A
--
M
E
S
G
A
H
D
F
I
S
G
---
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
YE
S
--
P
E
W
--
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
--
E
R
--
G
G
C
Y
R
S
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
49.25
33%
-67
- C2 -
2IXF
4
D:
[12-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
M
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
-
H
-
P
-
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
L
L
F
G
R
-
S
F
R
-
E
N
I
--------
A
Y
G
L
T
-
R
T
---
P
---
T
M
E
E
-
I
T
A
V
A
--
M
E
S
G
A
H
D
F
I
S
G
---
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
YE
S
--
P
E
W
--
A
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
--
E
R
--
G
G
C
Y
R
S
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
48.59
33%
-71
- C2 -
2IXF
4
TAP1_RAT
B:
[12-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
--
M
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
P
N
-
H
-
P
-
N
V
Q
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
--
V
Q
--
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
-
S
F
R
-
E
N
I
--------
A
Y
G
L
T
-
R
T
---
P
---
T
M
E
E
-
I
T
A
V
A
--
M
E
S
G
A
H
D
F
I
S
G
---
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
-
L
L
Y
E
S
--
P
E
W
--
A
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
-
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
M
--
E
R
--
G
G
C
Y
R
S
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
47.67
36%
-64
- C2 -
1JJ7
2
A:
[11-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
--
G
L
V
Q
F
Q
D
V
S
F
A
Y
P
N
-
R
-
P
-
D
V
L
V
L
Q
G
L
T
F
T
L
R
P
G
E
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
Q
L
L
L
D
G
K
P
L
--
P
Q
--
Y
E
H
R
Y
L
H
R
Q
V
A
A
V
G
Q
E
P
Q
V
F
G
R
-
S
L
Q
-
E
N
I
--------
A
Y
G
L
T
-
Q
K
---
P
---
T
M
E
E
-
I
T
A
A
A
--
V
K
S
G
A
H
S
F
I
S
G
---
L
P
Q
G
Y
D
T
E
V
D
E
A
G
S
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
C
V
L
I
L
D
D
A
T
S
A
L
D
A
N
S
Q
L
Q
V
E
Q
-
L
L
YE
S
--
P
E
R
--
Y
S
R
S
V
L
L
I
T
Q
H
L
S
L
V
E
Q
-
A
D
H
I
L
F
L
E
G
G
A
I
R
E
G
G
T
H
Q
Q
L
M
--
E
K
--
K
G
C
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
45.32
37%
-67
- C2 -
3VX4
3
?
D:
[28-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
F-
L
D
--
G
D
I
S
F
E
N
L
S
Y
K
Y
-
G
F
G
-
R
-
D
T
--
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
--
K
V
--
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
-
S
I
M
-
D
N
L
--------
V
L
G
-
A
-
K
E
---
G
---
T
S
Q
E
D
I
I
R
A
C
--
E
I
A
E
I
R
S
D
I
E
Q
---
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
-
N
L
-----
L
Q
M
--
T
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
--
A
K
--
Q
G
F
Y
Y
N
L
F
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
HHSearch
43.62
36%
-67
* C2 *
3VX4
3
?
A:
[29-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
--
L
D
--
G
D
I
S
F
E
N
L
S
Y
K
Y
-
G
-
F
-
G
--
R
D
T
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
--
K
V
--
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
-
S
I
M
-
D
N
L
--------
V
L
G
-
A
-
K
E
G--
T
---
S
Q
E
D
-
I
I
R
A
C
--
E
I
A
E
I
R
S
D
I
E
Q
---
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
-
N
L
--
L
--
Q
M
---
T
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
--
A
K
--
Q
G
F
Y
Y
N
L
F
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
43.57
37%
-68
- C2 -
3VX4
3
?
A:
[29-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F-
L
D
--
G
D
I
S
F
E
N
L
S
Y
K
Y
-
G
F
G
-
R
-
D
T
--
L
S
D
I
N
L
S
I
K
K
G
S
K
V
S
L
V
G
A
S
G
S
G
K
T
T
L
A
K
L
I
V
N
F
Y
E
P
N
---
K
G
I
V
R
I
N
G
N
D
L
--
K
V
--
I
D
K
T
A
L
R
R
H
I
S
Y
L
P
Q
Q
A
Y
V
F
S
G
-
S
I
M
-
D
N
L
--------
V
L
G
-
A
-
K
E
---
G
---
T
S
Q
E
D
I
I
R
A
C
--
E
I
A
E
I
R
S
D
I
E
Q
---
M
P
Q
G
Y
Q
T
E
L
S
D
-
G
A
G
I
S
G
G
Q
K
Q
R
I
A
L
A
R
A
L
L
T
Q
A
P
V
L
I
L
D
A
A
T
S
S
L
D
I
L
T
E
K
K
I
I
S
-
N
L
-----
L
Q
M
--
T
E
K
T
I
I
F
V
A
H
R
L
S
I
S
Q
R
-
T
D
E
V
I
V
M
D
Q
G
K
I
V
E
Q
G
T
H
K
E
L
L
--
A
K
--
Q
G
F
Y
Y
N
L
F
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
43.00
38%
-61
- C2 -
1MV5
3
LMRA_LACLA
C:
[5-231]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
-
D
---
D
-
S
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
--
D
N
--
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
-
T
I
R
-
E
N
L
--------
T
Y
G
L
E
-
G
D
---
Y
---
T
D
E
D
-
L
W
Q
V
L
--
D
L
A
F
A
R
S
F
V
E
N
---
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
-
A
L
--
D
--
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
--
A
T
--
H
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
40.51
38%
-51
- C2 -
1MV5
2
LMRA_LACLA
B:
[5-231]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
-
D
---
D
-
S
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
--
D
N
--
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
-
T
I
R
-
E
N
L
--------
T
Y
G
L
E
-
G
D
---
Y
---
T
D
E
D
-
L
W
Q
V
L
--
D
L
A
F
A
R
S
F
V
E
N
---
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
-
A
L
--
D
--
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
--
A
T
--
H
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
40.24
38%
-54
- C2 -
1MV5
3
LMRA_LACLA
A:
[5-231]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
-
D
---
D
-
S
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
--
D
N
--
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
-
T
I
R
-
E
N
L
--------
T
Y
G
L
E
-
G
D
---
Y
---
T
D
E
D
-
L
W
Q
V
L
--
D
L
A
F
A
R
S
F
V
E
N
---
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
-
A
L
--
D
--
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
--
A
T
--
H
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
39.50
38%
-53
- C2 -
1MV5
3
D:
[5-231]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
-
D
---
D
-
S
E
Q
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
--
D
N
--
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
-
T
I
R
-
E
N
L
--------
T
Y
G
L
E
-
G
D
---
Y
---
T
D
E
D
-
L
W
Q
V
L
--
D
L
A
F
A
R
S
F
V
E
N
---
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
-
A
L
--
D
--
S
L
M
--
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
-
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
--
A
T
--
H
P
L
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
31.54
32%
-53
- C2 -
4YMU
2
?
A:
[17-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
--
N
N
GK
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
-
L
T
A
I
E
N
I
T
LAPVKVK
K
M
N
-
K
-
K
E
---
A
---
E
E
L
A
-
V
D
L
L
A
--
K
V
G
----
L
L
D
K
---
K
D
---
Q
Y
P
I
K
-----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
K
E
-
V
L
--
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
YR
A
K
--
N
E
R
T
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
31.02
32%
-53
- C2 -
4YMV
1
?
J:
[17-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
--
N
N
GK
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
-
L
T
A
I
E
N
I
TLAPVKVK
K
M
N
-
K
-
K
E
---
A
---
E
E
L
A
-
V
D
L
L
A
--
K
V
G
----
L
L
D
K
---
K
D
---
Q
Y
P
I
K
-----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
K
E
-
V
L
--
N
VM
K
Q
L
AN
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
YR
A
K
--
N
E
R
T
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
30.66
32%
-55
- C2 -
4YMV
1
?
A:
[17-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
--
N
N
GK
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
-
L
T
A
I
E
N
I
T
LAPVKVK
K
M
N
-
K
-
K
E
---
A
---
E
E
L
A
-
V
D
L
L
A
--
K
V
G
----
L
L
D
K
---
K
D
---
Q
Y
P
I
K
-----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
K
E
-
V
L
--
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
YR
A
K
--
N
E
R
T
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
30.41
32%
-53
- C2 -
4YMU
2
?
J:
[17-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
---
K
G
E
V
F
I
D
G
V
K
I
--
N
N
GK
V
N
I
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
-
L
T
A
I
E
N
I
TLAPVKVK
K
M
N
-
K
-
K
E
---
A
---
E
E
L
A
-
V
D
L
L
A
--
K
V
G
----
L
L
D
K
---
K
D
---
Q
Y
P
I
K
-----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
K
E
-
V
L
--
N
VM
K
Q
L
AN
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
YR
A
K
--
N
E
R
T
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
30.32
32%
-49
- C2 -
3C4J
4
?
B:
[40-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
KA
K
D
--
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
-
N
N
I
--------
T
L
A
-
P
-
M
K
---
V
---
R
K
W
P
-
R
E
K
A
E
----
A
K
A
M
E
L
L
D
K
VGL
K
D
K
A
H
A
Y
P
-----
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
-
V
L
--
S
VM
K
Q
L
AN
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
--
D
R
--
P
Q
H
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
29.81
32%
-51
- C2 -
2OLJ
4
?
A:
[40-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
KA
K
D
--
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
-
N
N
I
--------
T
L
A
-
P
-
M
K
---
V
---
R
K
W
P
-
R
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
-----
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
-
V
L
--
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
--
D
R
--
P
Q
H
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
29.39
32%
-46
- C2 -
3C4J
3
?
A:
[40-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
KA
K
D
--
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
-
N
N
I
--------
T
L
A
-
P
-
M
K
---
V
---
R
K
W
P
-
R
E
K
A
E
----
A
K
A
M
E
L
L
D
K
V
GL
K
D
K
A
H
A
Y
P
-----
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
-
V
L
--
S
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
--
D
R
--
P
Q
H
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
27.98
32%
-46
- C2 -
2OLJ
3
?
B:
[40-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
---
E
G
E
I
I
I
D
G
I
N
L
KA
K
D
--
T
N
L
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
-
N
N
I
--------
T
L
A
-
P
-
M
K
---
V
---
R
K
W
P
-
R
E
K
A
E
----
A
K
A
M
E
L
L
D
K
VGL
K
D
K
A
H
A
Y
P
-----
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
---
E
M
V
G
E
-
V
L
--
S
VM
K
Q
L
AN
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
--
D
R
--
P
Q
H
E
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
25.74
31%
-49
- C2 -
1R0Z
3
CFTR_MOUSE
B:
[51-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
---------------
I
I
K
H
S
G
R
--
V
S
F
C
S
Q
F
S
W
I
M
P
G
-
T
I
K
-
E
N
I
--------
I
F
G
--------
V
---
S
Y
D
E
-
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
---
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
V
F
E
S
C
V
--
C
--
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
-
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
25.49
31%
-52
- C2 -
1R0Z
3
CFTR_MOUSE
C:
[51-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
---------------
I
I
K
H
S
G
R
--
V
S
F
C
S
Q
F
S
W
I
M
P
G
-
T
I
K
-
E
N
I
--------
I
F
G
--------
V
---
S
Y
D
E
-
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
---
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
V
F
E
S
C
V
--
C
--
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
-
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
25.18
31%
-48
- C2 -
1R0Z
3
D:
[51-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
---------------
I
I
K
H
S
G
R
--
V
S
F
C
S
Q
F
S
W
I
M
P
G
-
T
I
K
-
E
N
I
--------
I
F
G
--------
V
---
S
Y
D
E
-
Y
R
Y
K
S
VV
K
A
C
Q
L
Q
Q
D
I
T
K
---
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
V
F
E
S
C
V
--
C
--
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
-
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
24.87
31%
-48
- C2 -
1XFA
5
B:
[52-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
---------------
I
I
K
H
S
G
R
--
V
S
F
C
S
Q
F
S
W
I
M
P
G
-
T
I
K
-
E
N
I
--------
I
R
G
--------
V
---
S
Y
D
E
-
Y
R
Y
K
S
VV
K
A
C
Q
L
Q
Q
D
I
T
K
---
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
V
F
E
-
S
C
V-
C
--
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
-
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
24.57
31%
-50
- C2 -
1R10
3
B:
[52-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
---------------
I
I
K
H
S
G
R
--
V
S
F
C
S
Q
F
S
W
I
M
P
G
-
T
I
K
-
E
N
I
--------
I
F
G
--------
V
---
S
Y
D
E
-
Y
R
Y
K
S
VV
K
A
C
Q
L
Q
Q
D
I
T
K
---
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
V
F
E
S
C
V
--
C
--
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
-
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
23.85
31%
-48
- C2 -
1R0Z
4
CFTR_MOUSE
A:
[51-246]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
---------------
I
I
K
H
S
G
R
--
V
S
F
C
S
Q
F
S
W
I
M
P
G
-
T
I
K
-
E
N
I
--------
I
F
G
--------
V
---
S
Y
D
E
-
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
---
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
V
F
E
S
C
V
--
C
--
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
-
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
23.82
31%
-49
- C2 -
1XFA
6
CFTR_MOUSE
A:
[52-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
L
K
N
I
N
L
N
I
E
K
G
E
M
L
A
I
T
G
S
T
G
S
G
K
T
S
L
L
M
L
I
L
G
E
L
E
A
S
---
E
G
---------------
I
I
K
H
S
G
R
--
V
S
F
C
S
Q
F
S
W
I
M
P
G
-
T
I
K
-
E
N
I
--------
I
R
G
--------
V
---
S
Y
D
E
-
Y
R
Y
K
S
V
V
K
A
C
Q
L
Q
Q
D
I
T
K
---
F
A
E
Q
D
N
T
V
L
G
E
G
G
V
T
L
S
G
G
Q
R
A
R
I
S
L
A
R
A
V
Y
K
D
A
D
L
Y
L
L
D
S
P
F
G
Y
L
D
V
F
T
E
E
Q
V
F
E
-
S
C
V-
C
--
K
L
M
--
A
N
K
T
R
I
L
V
T
S
K
M
E
H
L
R
K
-
A
D
K
I
L
I
L
H
Q
G
S
S
Y
F
Y
G
T
F
S
E
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------