@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2756: (2016-04-07 )
MTKTLVLAEKPSVGKDIGRVLGAKQGKNGYLEGGKYVVTWALGHLVTLADPERYDSKYKNWNMEDLPMLPEKMKLEPIKQTRKQYETVKKLMNRTDITTIVIATDAGREGELVARWIIDYAKIKKPLKRLWISSVTDKAIREGFEHLKPGKAYENLYHSAVARSEADWVVGINATRALTTKYNAQLSCGRVQTPTLAMIQHREEEIRNFKSREYYGITALTEQESFTWNNGQTFDKALAEKLVKSLQGENAVITDVSMKEKKTFSPGLYDLTELQRDANNRYDFSAKETLNIMQTLYERHKVLTYPRTDSRFISTDIVPTLKERLVACGVGENAKAARQISVKPIKANKSFVDNSKVSDHHAIIPTEQPVSLGDLSDKERKIYDLVVKRFLAVLSDPYIYEETSVKAKIGQEEFTLKGKVVKSLGWKSIYGESREPDQLTKMKKGDTIPVKRINLETGKTKPPARFDEATLLSAMENPSKYMETTNKALAKTLGETGGLGTVATRADIIEKLFNSFSLEKQGKDIQITSKGRQLLELVPEDLKSPELTARWEQKLSKIAKGELDYRKFTAEMRDYAKKAVTEIKQNDKKFRHDNITSQKCPDCGKPMLKVKGKRGTMLVCQDRECGHRESVSRTTNARCPNCHKRMEMRGEGDKQIFVCVCGHREKLSAFQQRRDKQKNKNVSKTDVAKFMKKQNKQEDEPFNNPMAEALAKLKLDK
Atome Classification :
(20 SA)
------------.........10........20--...-...-..--------------30.-..-.-----....40.-.......--------50........60----..-.......70........80........90....--....100.......110.......120.----.-..---.---..130.......140.......150.......160.......170.......-----180.---------..---------....190.......200.......210......----.---220..---.----.--.--..-----------230--------....-.....240..-..-...250.......260.......270.......280.......290......-------.-------300-------.......310.......320.......330.-......340------.--......350.......-360.....---..370--.----..-.....380.......390.......400.......410.......420-...--.....430..-----.-...------.440-.......450.......460.......470.......480.......490.......500.......510--.........520........530.......540-....---.....550.......560..-----------.....570.......----------580.......590.......600.......610-.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------M
T
K
T
L
V
L
AEKPS
V
G
K
D
I
G
R
V
L--GAK-QGK-NG--------------YLE-G
G
-
K
-----
Y
V
V
T
WAL-G
H
L
V
TLA--------
D
P
E
R
Y
D
S
K
YKN-----WN-MEDLPML
P
E
K
MKL
E
P
I
K
Q
T
R
K
Q
Y
E
T
V
K
K
L
MNRT--D
I
T
T
I
V
I
ATDAGRE
G
E
L
V
A
R
W
I
I
D
Y
A
K
I
----
K
-
K
P
---
L
---
K
R
L
W
I
S
SV
T
D
K
A
I
R
E
G
F
E
HLKP
G
K
A
Y
E
N
L
Y
H
S
A
V
ARSEA
D
W
V
V
GINA
T
R
A
L
T
-----
T
KYN---------
A
Q
---------LSCGRVQT
P
T
L
A
M
I
Q
H
R
E
E
E
I
R
NFKSR
E
Y
Y
G
I
T
----
A
---
L
TEQ
E
---
S
----
F
--T--WN-----------N----------G
Q
T
F
-
D
K
A
L
A
E
K
L
V
K
-
S
L-QGE
N
A
V
I
T
DVSMKEKKTFSPG
L
Y
D
L
T
E
L
Q
R
DANNRYDF
S
A
K
E
T
L
N
I
M
Q
T
L
Y
E
-------R-------H
K
V
-------
L
TYPRTDS
R
F
IS
T
D
I
V
P
T
L
K
E
R
L
V
ACGVGEN-AKA
A
R
Q
I
S
V
------
K
--
P
IKANKSFVDNSKVSD-H
H
A
IIPTE---QPVS---L----GD-LS
D
K
E
R
K
I
Y
D
L
V
V
K
R
F
L
A
VLSDP
Y
I
YEETS
V
K
A
KIGQE
E
F
T
L
K
G
K
V
V
--
K
SL--G
W
K
S
IYGESR-----E-
P
D
Q
------
L
T
KM-KKGDTI
P
V
K
R
I
NLETGKTKPPARF
D
E
A
T
L
L
S
A
ME
N
P
S
K
Y
M
E
T
T
N
K
A
L
A
K
T
L
GETGGL
G
T
V
A
T
R
A
D
I
I
E
----
K
L
F
N
SFSLEKQ-G
K
D
I
Q
I
T
S
K
G
R
Q
L
L
E
L
V
P
E
---
D
LKS---P
E
L
T
A
R
W
E
Q
K
L
S
K
I
AKGE
L
D
-----------
Y
R
K
F
T
A
E
M
R
D
Y
A
K
K
A
----------
V
T
E
I
K
QN
D
K
KFRHDNITSQKCPDCGKPM
L
K
V
KG-KRG
T
M
L
V
CQDRECG
H
R
E
SVSRTTNARCP
N
C
H
K
R
M
E
MRGEGD
K
Q
I
F
V
C
VCG
H
R
E
K
L
S
A
F
Q
Q
R
R
D
K
QKNKNV
S
K
T
D
V
A
K
F
M
K
KQNKQEDEPFN
N
P
M
A
E
A
L
A
K
LKLDK-
26
HHSearch
91.90
33%
-66
- C2 -
1I7D
3
TOP3_ECOLI
A:
[1-620]
--------------
M
R
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
H
R
K
G
-
D
G
--------------
F
I
E
-
C
G
N
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
-----
I
L
G
R
N
A
GYQ----
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
---
H
I
V
T
P
AD
E
R
----
F
T
A
I
--
W
Q
-----------
P
S
EACEPYQDE
E
G
R
L
L
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
F
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
--
H
-
A
--
P
D
L
L
P
Q
------
P
VV
D
P
D
I
R
N
R
C
W
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
--------
I
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
S
K
E
RDEEN
D
-
G
T
P
------
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
D
--
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
M
Q
P
L
V
G
T
L
Y
Q
L
----------
I
D
Q
A
K
R
T
P
----
V
R
Q
F
R
G
I
V
A
P
----------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
89.25
33%
-68
- C2 -
2O59
3
TOP3_ECOLI
B:
[3-621]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
H
I
V
T
P
A
D
E
---
R
----
F
--
T
A
I
W
Q
P
S
EACEPYQDE
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
-----
E
-
R
D
E
ENDG
T
P
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
89.20
33%
-73
- C2 -
2O19
3
TOP3_ECOLI
A:
[3-619]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
H
I
V
T
P
A
D
E
---
R
----
F
--
T
A
I
W
Q
P
S
EACEPYQDE
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
-----
E
-
R
D
E
ENDGTP
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
88.85
33%
-69
- C2 -
2O5C
2
TOP3_ECOLI
B:
[3-618]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
APEK
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
ILGRN
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
HIV
T
P
A
D
E
---
R
----
F
--
T
AI
W
Q
PSEACEPYQDE
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
-----
E
-
R
D
E
ENDGTP
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
88.82
33%
-70
- C2 -
1I7D
3
TOP3_ECOLI
A:
[3-591]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
H
I
V
T
P
A
D
E
---
R
----
F
--
T
A
I
W
Q
P
S
EACEPYQDE
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
F
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
-----
E
-
R
D
E
ENDGTP
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
88.67
33%
-68
- C2 -
2O54
2
TOP3_ECOLI
B:
[3-618]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
APEK
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
ILGRN
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
HIV
T
P
A
D
E
---
R
----
F
--
T
AI
W
Q
PSEACEPYQDE
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
-----
E
-
R
D
E
ENDGTP
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.66
33%
-74
- C2 -
2O54
3
TOP3_ECOLI
A:
[3-619]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
H
I
V
T
P
A
D
E
---
R
----
F
--
T
A
I
W
Q
PSEACEPYQDE
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
-----
E
-
R
D
E
ENDGTP
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.63
33%
-71
- C2 -
2O5E
3
TOP3_ECOLI
A:
[3-616]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
HIV
T
P
A
D
E
---
R
----
F
--
T
A
I
W
Q
PSEACEPYQDE
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
-----
E
-
R
D
E
END
G
T
P
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.28
33%
-67
- C2 -
2O5E
2
TOP3_ECOLI
B:
[3-618]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
APEK
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
ILGRN
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
HIV
T
P
A
D
E
---
R
----
F
--
T
AI
W
Q
PSEACEPYQDE
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
-----
E
-
R
D
E
ENDGTP
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.25
33%
-68
- C2 -
2O5C
3
TOP3_ECOLI
A:
[3-616]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
H
I
V
T
P
A
D
E
---
R
----
F
--
T
A
I
W
Q
P
S
EACEPYQDE
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
-----
E
-
R
D
E
ENDGTP
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
87.80
33%
-69
- C2 -
2O19
2
TOP3_ECOLI
B:
[3-618]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
APEK
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
ILGRN
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
HIV
T
P
A
D
E
---
R
----
F
--
T
AI
W
Q
PSEACEPYQDE
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
-----
E
-
R
D
E
ENDGTP
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.41
33%
-68
- C2 -
1D6M
-
TOP3_ECOLI
A:
[3-591]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G---------------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
H
I
V
T
P
A
D
E
---
R
----
F
--
T
A
I
W
Q
P
S
EACEPYQDE
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
-----
E
-
R
D
E
ENDGTP
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.40
33%
-74
- C2 -
2O59
2
TOP3_ECOLI
A:
[3-623]
----------------
L
F
I
A
E
K
P
S
L
A
R
A
I
A
D
V
L
--
P
K
P
-
H
R
K
G
D
G
--------------
F
I
E
C
G
N
-
G
-----
Q
V
V
T
W
C
I
-
G
H
L
L
E
Q
A
--------
Q
P
D
A
Y
D
S
R
Y
A
R
-----
W
N
-
L
A
D
L
P
I
V
P
E
K
W
Q
L
Q
P
R
P
S
V
T
K
Q
L
N
V
I
K
R
F
L
H
----
E
A
S
E
I
V
H
A
G
D
P
D
R
E
G
Q
L
L
V
D
E
V
L
D
Y
L
Q
L
A
P
E
K
R
-
Q
Q
---
V
---
Q
R
C
L
I
N
D
L
N
P
Q
A
V
E
R
A
I
D
R
L
R
S
N
S
E
F
V
P
L
C
V
S
A
L
A
R
A
R
A
D
W
L
Y
G
I
N
M
T
R
A
Y
T
I
L
G
R
N
A
G
Y
Q
---------
G
V
---------
L
S
V
G
R
V
Q
T
P
V
L
G
L
V
V
R
R
D
E
E
I
E
N
F
V
A
K
D
F
F
E
V
K
----
A
H
I
V
T
P
A
D
E
---
R
----
F
--
T
A
I
W
Q
P
SCEPYQDE--
E
----------
G
R
L
L
-
H
R
P
L
A
E
H
V
V
N
-
R
I
-
S
G
Q
P
A
I
V
T
S
Y
N
D
K
R
E
S
E
S
A
P
L
P
F
S
L
S
A
L
Q
I
E
A
A
K
R
F
G
L
S
A
Q
N
V
L
D
I
C
Q
K
L
Y
E
-------
T
-------
H
K
L
-------
I
T
Y
P
R
S
D
C
R
Y
L
P
E
E
H
F
A
G
R
H
A
V
M
N
A
I
S
V
-
H
A
-
P
D
L
L
P
Q
P
V
V
------
D
--
P
D
I
R
N
R
C
W
-
D
D
K
K
V
D
A
-
H
H
A
I
I
P
T
A
---
R
S
S
A
---
I
-----
N
-
L
T
E
N
E
A
K
V
Y
N
L
I
A
R
Q
Y
L
M
Q
F
C
P
D
A
V
F
R
K
C
V
I
E
L
D
I
A
K
G
K
F
V
A
K
A
R
F
L
--
A
E
A
--
G
W
R
T
L
L
G
-
S
K
----------NDGTP-
L
P
V
V
-
A
K
G
D
E
L
L
C
E
K
G
E
V
V
E
R
Q
T
Q
P
P
R
H
F
T
D
A
T
L
L
S
A
M
T
G
I
A
R
F
V
Q
--
D
K
D
L
K
K
I
L
R
A
T
D
G
L
G
T
E
A
T
R
A
G
I
I
E
----
L
L
F
K
R
G
F
L
T
K
K
-
G
R
Y
I
H
S
T
D
A
G
K
A
L
F
H
S
L
P
E
---
M
A
T
R
---
P
D
M
T
A
H
W
E
S
V
L
T
Q
I
S
E
K
Q
C
R
-----------
Y
Q
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
78.82
26%
-47
- C2 -
4CGY
1
TOP3A_HUMAN
A:
[22-640]
FS
R
A
A
M
E
M
A
L
RG
V
R
K
V
L
C
V
A
E
K
N
D
A
A
K
G
I
A
D
L
L
--
S
---
N
G
R
-
M
R
--------------
R
R
E
-
G
L
-
S
KF
N
K
I
Y
E
F
D
Y
H
L
Y
G
Q
N
V
T
M
V
M
T
S
V
SGHL
L
A
H
D
F
Q
M
Q
F
R
K
-----
W
Q
-
S
C
N
P
L
V
L
F
E
---
A
E
I
E
K
Y
C
P
E
N
F
V
D
I
K
K
T
L
E
R
E
T
R
Q
C
Q
A
L
V
I
W
T
D
C
D
R
E
G
E
N
I
G
F
E
I
I
H
V
C
K
A
----
V
-
K
P
N
L
Q
V
---
L
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
C
E
N
L
T
E
P
D
--
Q
R
V
S
D
A
V
D
V
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
-----
L
R
L
Q
---------
R
I
F
PEVLAEQL
I
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
I
K
----
V
---
T
H
D
H
K
---
D
G
I
V
E
F
--
N
--
W
K
-----------
R
----------
H
R
L
F
-
N
H
T
A
C
L
V
L
Y
Q
-
L
C
V
E
D
P
M
A
T
V
V
E
V
R
S
K
P
K
S
K
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
K
E
T
M
R
I
A
E
K
L
Y
T
-------
Q
-------
G
Y
I
--------
S
Y
P
R
T
E
T
N
I
F
P
R
D
L
--
N
L
T
V
L
V
E
Q
Q
T
P
D
P
R
W
G
A
F
A
Q
S
I
L
E
------
R
GG
P
T
P
R
N
G
N
K
S
D
Q
A
-----
H
P
P
I
H
P
T
K
---
Y
T
----------
N
N
-
L
Q
G
D
E
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
A
Q
E
R
F
V
A
H
G
L
M
I
--
L
A
R
--
N
Y
L
D
V
Y
P
Y
D
H
-----
W
-
S
D
K
I-----
L
P
V
Y
-
E
Q
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
E
T
S
P
P
K
L
L
T
E
A
D
L
I
A
L
M
E
K
H
-------------------
G
I
G
T
D
A
T
H
A
E
H
I
E
----
T
I
K
A
R
M
Y
V
G
L
T
P
D
K
R
F
L
P
G
H
L
G
M
G
L
V
E
G
Y
D
S
MGY
E
M
S
K
---
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
K
D
-----------
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
----------
F
I
E
A
V
A
K
---------------------------------------------------------------------------------------------------------------------
A
K
K
L
D
E
A
L
A
Q
Y
F
G
N
G
T
20
PsiBlast_PDB
76.07
23%
-45
- C2 -
4CGY
1
TOP3A_HUMAN
A:
[36-640]
--------------
K
V
L
C
V
A
E
K
N
D
A
A
K
G
I
A
D
L
L
S
N
G
R
M
-
R
R
R
-
E
G
LSKF
N
K
I
Y
E
F
D
Y
H
L
Y
G
Q
-
N
V
-
T
-----
M
V
M
T
S
V
S
-
G
H
L
L
A
------------
H
D
F
Q
M
Q
F
R
K
-----
W
Q
-
S
C
N
-
P
L
V
L
F
E
A
E
I
E
--
K
Y
C
P
E
N
F
V
D
I
K
K
T
L
E
R
E
T
R
Q
C
Q
A
L
V
I
W
T
D
C
D
R
E
G
E
N
I
G
F
E
I
I
H
V
C
K
A
----
V
-
K
P
N
L
Q
V
---
L
R
A
R
F
S
E
I
T
P
H
A
V
R
T
A
C
E
N
L
T
--
E
P
D
Q
R
V
S
D
A
V
D
V
R
Q
E
L
D
L
R
I
G
A
A
F
T
R
F
Q
T
-----
L
R
L
Q
R
I
F
PEVLAE
Q
L
---------
I
S
Y
G
S
C
Q
F
P
T
L
G
F
V
V
E
R
F
K
A
I
Q
A
F
V
P
E
I
F
H
R
I
K
----
V
---
T
H
D
H
K
---
D
G
I
V
E
F
--
N
--
W
K
-----------
R
----------
H
R
L
F
-
N
H
T
A
C
L
V
L
Y
Q
L
C
V
-
E
D
P
M
A
T
V
V
E
V
R
S
K
P
K
S
K
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
A
S
R
K
L
R
I
N
A
K
E
T
M
R
I
A
E
K
L
Y
T
-------
Q
--------
G
Y
-------
I
S
Y
P
R
T
E
T
N
I
F
P
R
D
L
N
L
T
V
---
L
V
E
Q
Q
T
P
D
P
-
R
W
G
A
F
A
Q
S
I
L
E
R
GGP
T
--
P
R
N
G
N
K
S
--
D
Q
A
-----
H
P
P
I
H
P
T
K
------
Y
---
T
----
N
N
-
L
Q
G
D
E
Q
R
L
Y
E
F
I
V
R
H
F
L
A
C
C
S
Q
D
A
Q
G
Q
E
T
T
V
E
I
D
I
A
Q
E
R
F
V
A
H
G
L
M
I
--
L
A
R
--
N
Y
L
D
V
Y
P
Y
D
H
-----
W
-
S
D
K
------
I
L
P
V
Y
E
Q
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
E
T
S
P
P
K
L
L
T
E
A
D
L
I
A
L
M
E
K
-------------------
H
G
I
G
T
D
A
T
H
A
E
H
I
E
T
I
K
A
R
M
Y
V
G
L
T
P
D
K
R
-
F
L
P
G
H
L
G
M
G
L
V
E
G
Y
D
S
M
G
Y
---
E
M
S
K
---
P
D
L
R
A
E
L
E
A
D
L
K
L
I
C
D
G
K
K
D
K
F
V
V
L
R
Q
Q
V
Q
K
Y
K
Q
V
F
I
E
A
V
A
K
A
K
K
L
D
E
A
L
A
Q
Y
FGN
G
T
------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
76.01
25%
-62
* C2 *
1MW9
9
TOP1_ECOLI
X:
[2-581]
-------------
G
K
A
L
V
I
V
E
S
P
A
K
A
K
T
I
N
K
Y
L
--
G
S
-----------------------------
D
-----
Y
V
V
K
S
S
V
-
G
H
I
R
D
L
P
--------
T
----------ERGAL
V
N
R
M
G
V
D
P
W
H
N
W
E
A
H
Y
E
V
L
P
G
K
E
K
V
V
S
E
L
K
Q
L
A
E
----
K
A
D
H
I
Y
L
A
T
D
L
D
R
E
G
E
A
I
A
W
H
L
R
E
V
I
G
G
----
D
D
A
R
---
Y
---
S
R
V
V
F
N
E
I
T
K
N
A
I
R
Q
A
F
N
K
P
G
--
E
L
N
I
D
R
V
N
A
Q
Q
A
R
R
F
M
D
R
V
V
G
Y
M
V
S
P
L
L
W
-----
K
K
I
A
---------
R
G
---------
L
S
A
G
R
V
Q
S
V
A
V
R
L
V
V
E
R
E
R
E
I
K
A
F
V
P
E
E
F
W
E
V
D
----
A
---
S
T
T
T
P
SGE
A
----
L
--
A
LQ
V
T
HQ---------
N
DK--------
P
F
R
P
V
N
K
E
Q
T
Q
A
A
V
S
-
L
L
-
E
K
A
R
Y
S
V
L
E
R
E
D
K
P
T
T
S
K
P
G
A
P
F
I
T
S
T
L
Q
Q
A
A
S
T
R
L
G
F
G
V
K
K
T
M
M
M
A
Q
R
L
Y
E
-------
A
--------
G
Y
-------
I
T
Y
M
R
T
D
S
T
N
L
S
Q
D
A
V
N
M
V
R
G
Y
I
S
D
N
----
F
-
G
--
K
K
Y
L
P
E
-----------
S
P
N
Q
Y
A
---------
R
E
A
I
R
P
S
D
---
V
N
V
M
AES
L
----
K
D
-
M
E
A
D
A
Q
K
L
Y
Q
L
I
W
R
Q
F
V
A
C
Q
M
T
P
A
K
Y
D
S
T
T
L
T
V
G
A
G
D
F
R
L
K
A
R
G
R
I
L
--
R
F
D
--
G
W
T
K
V
M
P
A
L
-------E
D
R
I
------
L
P
A
V
-
N
K
G
D
A
L
T
L
V
E
L
T
P
A
Q
H
F
T
K
P
P
A
R
F
S
E
A
S
L
V
K
E
L
E
K
-------------------
R
G
I
G
R
P
S
T
Y
A
S
I
I
S
----
T
I
Q
D
R
G
Y
V
R
V
E
-
N
R
R
F
Y
A
E
K
M
G
E
I
V
T
D
R
L
E
E
NFR
E
L
M
N
---
Y
D
F
T
A
Q
M
E
N
N
L
D
Q
V
A
N
H
E
A
E
-----------
W
K
A
V
L
D
H
F
F
S
D
F
T
Q
Q
----------
L
D
K
A
E
K
D
-------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.58
27%
-53
- C2 -
2GAI
-
TOP1_THEMA
A:
[7-586]
---------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
--
G
----------------------------
N
-
E
-----
Y
E
V
F
A
S
M
-
G
H
I
I
D
L
P
--------
K
-----
S
K
F
G
V
-----
D
L
-
E
K
D
F
E
--
P
E
---
F
A
V
I
K
G
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
--
E
L
---
L
I
A
S
D
M
D
R
E
G
E
A
I
A
-
W
H
I
--
A
R
V
----
T
-
N
T
---
L
GRK
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
--
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
-----
R
N
F
K
---------
S
N
---------
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
V
N
F
D
G
---
L
T
A
E
---------
I
--
D
--
V
K
-----------
E
----------
K
K
F
F
-
D
---
A
E
T
L
K
E
-
I
Q
-
S
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
KD
G
H
-------
I
A
F
-------
I
T
Y
M
R
T
D
S
T
R
V
S
-
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
E
E
-
Y
V
G
-------------------------------A
H
E
A
I
R
P
T
N
VFM
T
P
E
E
---
A
----
G
K
Y
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
G
K
Y
R
F
K
G
T
V
L
--
K
K
I
FD
G
Y
E
K
V
W
K
T
E
R
-----
N
-
T
G
E
------
F
P
-
F
-
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
-------------------
G
I
G
R
P
S
T
Y
A
S
T
I
K
----
L
L
L
N
R
G
Y
I
K
K
I
-
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
KYS
D
V
V
S
---
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
--------------
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
----------
S
S
V
F
D
R
N
D
-
R
I
V
V
D
F
P
T
N
Q
K
C
-
S
C
G
K
E
M
R
L
S
F
G
-
K
Y
G
F
Y
L
K
C
---
E
C
G
K
T
R
S
V
---------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.43
27%
-54
- C2 -
2GAJ
-
TOP1_THEMA
A:
[7-586]
---------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
--
G
----------------------------
N
-
E
-----
Y
E
V
F
A
S
M
-
G
H
I
I
D
L
P
--------
K
-----
S
K
F
G
V
-----
D
L
-
E
K
D
F
E
--
P
E
---
F
A
V
I
K
G
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
--
E
L
---
L
I
A
S
D
M
D
R
E
G
E
A
I
A
-
W
H
I
--
A
R
V
----
T
-
N
T
---
L
GRK
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
--
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
-----
R
N
F
K
---------
S
N
---------
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
V
N
F
D
G
---
L
T
A
E
---------
I
--
D
--
V
K
-----------
E
----------
K
K
F
F
-
D
---
A
E
T
L
K
E
-
I
Q
-
S
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
G
V
E
T
KD
G
H
-------
I
A
F
-------
I
T
Y
M
R
T
D
S
T
R
V
S
-
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
F
G
E
E
-
Y
V
G
-------------------------------A
H
E
A
I
R
P
T
N
VFM
T
P
E
E
---
A
----
G
K
Y
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
G
K
Y
R
F
K
G
T
V
L
--
K
K
I
FD
G
Y
E
K
V
W
K
T
E
R
-----
N
-
T
G
E
------
F
P
-
F
-
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
-------------------
G
I
G
R
P
S
T
Y
A
S
T
I
K
----
L
L
L
N
R
G
Y
I
K
K
I
-
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
K
YS
D
V
V
S
---
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
--------------
K
T
D
K
I
V
L
R
E
F
Y
E
S
F
----------
S
S
V
F
D
R
N
D
-
R
I
V
V
D
F
P
T
N
Q
K
C
-
S
C
G
K
E
M
R
L
S
F
G
-
K
Y
G
F
Y
L
K
C
---
E
C
G
K
T
R
S
V
---------------------------------------------------------------------------------------
27
HHSearch
74.28
26%
-47
- C2 -
2GAI
-
TOP1_THEMA
A:
[7-601]
---------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
--
G
N
-----------------------------
E
-----
Y
E
V
F
A
S
M
-
G
H
I
I
D
L
P
--------
K
S
K
-
F
-----
G
-----
V
D
-
L
--
E
K
D
F
E
--
P
E
F
A
V
I
K
G
K
E
K
V
V
E
K
L
K
D
L
A
K
----
K
-
G
E
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
----
L
-
G
R
---
K
---
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
P
R
-
E
I
D
M
-
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
-----
R
N
F
K
---------
S
N
---------
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
----
V
---
N
F
D
G
L
T
A
-
E
----
I
--
D
--
V
K
----------------------
E
K
K
F
F
D
A
E
T
L
K
E
I
Q
S
-----
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
-------
G
V
E
T
KD
G
H
I
A
F
-------
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
----
F
-
G
--
E
E
Y
V
G
-------------------------
A
-
H
E
A
I
R
P
T
N
---
V
F
M
T
---
P
EEAG
K
Y
-
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
G
K
Y
R
F
K
G
T
V
L
K
K
I
F
D
--
G
Y
E
K
V
W
K
T
E
R
-----
N
--
T
G
------
E
F
P
F
-
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
-------------------
L
G
I
G
R
P
S
T
Y
A
S
T
I
K
----
L
L
L
N
R
G
Y
I
K
K
I
-
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
KYS
D
V
V
S
---
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
-----------
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
----------
F
D
R
N
D
R
I
V
----
V
D
F
P
T
N
Q
K
C
S
-
C
G
K
E
M
R
-
L
S
F
G
K
Y
G
F
Y
L
K
C
---
E
C
G
K
T
R
S
V
K
N
---------
D
E
I
A
V
I
-
D
D
G
K
I
F
L
--------------------------------------------------------------
52
Fugue
73.19
26%
-38
- C2 -
2GAI
-
TOP1_THEMA
A:
[7-601]
---------------
K
Y
I
V
V
E
S
P
A
K
A
K
T
I
K
S
I
L
--
G
N
E
----------------------------------
Y
E
V
F
A
S
M
-
G
H
I
I
D
L
P
--------
K
S
K
F
G
V
D
L
E
K
D
-----
F
-----------
E
P
E
F
A
V
I
K
G
K
E
K
V
V
E
K
L
K
D
L
A
K
K
G
--
E
---
L
L
I
A
S
D
M
D
R
E
G
E
A
I
A
W
H
I
A
R
V
T
N
T
----
L
-
G
R
---
K
---
N
R
I
V
F
S
E
I
T
P
R
V
I
R
E
A
V
K
N
--
P
R
E
I
D
M
K
K
V
R
A
Q
L
A
R
R
I
L
D
R
I
V
G
Y
S
L
S
P
V
L
W
-----
R
N
F
K
---------
S
N
---------
L
S
A
G
R
V
Q
S
A
T
L
K
L
V
C
D
R
E
R
E
I
L
R
F
V
P
K
K
Y
H
R
I
T
----
V
---
N
F
D
G
L
---
T
----
A
--
E
--
I
D
----------------------
V
K
E
K
-
K
F
F
D
A
E
T
L
K
E
-
I
Q
-
S
I
D
E
L
V
V
E
E
K
K
V
S
V
K
K
F
A
P
P
E
P
F
K
T
S
T
L
Q
Q
E
A
Y
S
K
L
G
F
S
V
S
K
T
M
M
I
A
Q
Q
L
Y
E
-------
G
-------
V
E
T
KD
G
H
I
A
F
I
T
Y
M
R
T
D
S
T
R
V
S
D
Y
A
K
E
E
A
R
N
L
I
T
E
V
-
F
G
E
E
-
Y
V
G
A
H
E
-
A
I
------
R
--
P
T
N
V
F
M
T
----------------------
P
E
E
---
A
----
G
K
Y
L
N
S
D
Q
K
K
L
Y
E
L
I
W
K
R
F
L
A
S
Q
M
K
P
S
Q
Y
E
E
T
R
F
V
L
R
T
K
D
G
K
Y
R
F
K
G
T
V
L
--
K
K
I
FD
G
Y
E
K
V
W
K
T
E
R
-----
N
-
T
G
-------
E
F
P
F
-
E
E
G
E
S
V
K
P
V
V
V
K
I
E
E
Q
E
T
K
P
K
P
R
Y
T
E
G
S
L
V
K
E
M
E
R
L
-------------------
G
I
G
R
P
S
T
Y
A
S
T
I
K
----
L
L
L
N
R
G
Y
I
K
K
I
-
R
G
Y
L
Y
P
T
I
V
G
S
V
V
M
D
Y
L
E
K
---
K
Y
S
D
VVS
V
S
F
T
A
E
M
E
K
D
L
D
E
V
E
Q
G
K
K
T
-----------
D
K
I
V
L
R
E
F
Y
E
S
F
S
S
V
----------
F
D
R
N
D
R
I
V
V
-----
D
F
P
T
N
Q
K
C
S
C
G
K
E
M
R
L
S
F
G
-
K
Y
G
F
Y
L
K
C
---
E
C
G
K
T
R
S
V
K
N
D
E
I
A
V
I
D
------------
D
G
K
I
F
L
------------------------------------------------------------