@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2764: (2016-04-07 )
MKIAAFDIGGTALKMGVVLPHGEIILTKSAEISGSDGDQILAEMKVFLAENTDVTGIAVSAPGYVNPKTGLITMGGAIRRFDNFNLKEWLEAETGLPVAIENDANCALLAEKWLGKGQDLDDFLCLTIGTGIGGGIFSNGELVRGGRFRAGEFGYMFSERPGAFRPGKYTLNETTTMLVLRRQYAELTGRPLEEITGEEIFANYDAHDAVSERLITEFYTGICTGLYNLIYLFDPTHIFIGGGITSRPTFIAELKHHMESFGLRDTIIETATHKNQAGLLGAVYHFLQEENRHE
Atome Classification :
(21 SA)
--------------------------------------------------------------------------.........10........20...---------...-..30....-.-.--.----.----40.----......----.----50...--------...----...60........70........80..-......90....--....100.......110.......120.......130.......140.......150.......160------------..----...------------..170....-----...-180.......190---------.--------------.--------.......200.......210.....--..220.......230.......240....-.--..250........260------.------...----...270.......280.......290..-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------
M
K
I
A
A
F
DIGG
T
A
L
K
M
G
V
V
LPHG
E
I
---------
I
L
T
-KSAEISGS-D-
G
--
D
----
Q
----
I
L
A
----
E
M
K
V
F
L----A----E-NTD--------V
T
G
----
I
A
V
SAPGYVNPKT
G
L
I
TMG
G
A
I
RRFDN-F
N
L
K
E
W
L
EAETG--L
P
V
A
I
ENDA
N
C
A
L
L
A
E
K
WLGKGQ
D
L
D
D
F
L
C
L
T
IGTGIGGGIFSNG
E
L
VRGGRFRAGEF
G
Y
M
FSERPG------------AF----RPG------------
K
Y
T
LNE
T
T
T
-----
M
L
V
-
L
R
R
Q
Y
A
E
LTGR-----------
P
--------------
L
--------
E
E
ITGE
E
I
F
ANYD
A
H
D
A
V
S
E
R
L
I
T
E
--
F
Y
T
G
I
C
T
G
L
Y
N
L
I
Y
L
FDP
T
H
I
F
IGGGITS-R--
P
T
F
I
-
A
E
L
K
H
H
M
E
SFG------L------
R
D
T
----
I
I
E
TATHKNQAG
L
L
G
A
V
Y
H
F
L
Q
E
ENRHE-------
1
PsiBlast_PDB
100.00
97%
-127
- C1 -
4HTL
1
BGLK_LISMO
A:
[5-294]
---------------------------------------------------------------------------
K
I
A
A
F
D
I
G
G
T
A
L
K
M
G
V
V
L
P
H
G
E
I
---------
I
L
T
-
K
S
A
E
I
S
G
S
-
D
-
G
--
D
----
Q
----
I
L
A
----
E
M
K
V
F
L
----
A
----
E
-
N
T
D
--------
V
T
G
----
I
A
V
S
A
P
G
Y
V
N
P
K
T
G
L
I
T
M
G
G
A
I
R
R
F
D
N
-
F
N
L
K
E
W
L
E
A
E
T
G
--
L
P
V
A
I
E
N
D
A
N
C
A
L
L
A
E
K
W
L
G
K
G
Q
D
L
D
D
F
L
C
L
T
I
G
T
G
I
G
G
G
I
F
S
N
G
E
L
V
R
G
G
R
F
R
A
G
E
F
G
Y
M
F
S
E
R
P
G
------------
A
F
----
R
P
G
------------
K
Y
T
L
N
E
T
T
T
-----
M
L
V
-
L
R
R
Q
Y
A
E
L
T
G
R
-----------
P
--------------
L
--------
E
E
I
T
G
E
E
I
F
A
N
Y
D
A
H
D
A
V
S
E
R
L
I
T
E
--
F
Y
T
G
I
C
T
G
L
Y
N
L
I
Y
L
F
D
P
T
H
I
F
I
G
G
G
I
T
S
-
R
--
P
T
F
I
-
A
E
L
K
H
H
M
E
S
F
G
------
L
------
R
D
T
----
I
I
E
T
A
T
H
K
N
Q
A
G
L
L
G
A
V
Y
H
F
L
Q
E
E
N
----------
41
HHSearch
76.21
35%
-119
- C1 -
2GUP
4
?
A:
[4-291]
--------------------------------------------------------------------------
M
T
I
A
T
I
D
I
G
G
T
G
I
K
F
A
S
L
T
P
D
G
K
I
---------
L
D
K
-
T
S
I
S
T
P
E
--
N
-
L
--
E
----
D
----
L
L
A
----
W
L
D
Q
R
L
---------
S
-
E
Q
D
--------
Y
S
G
----
I
A
M
S
V
P
G
A
V
N
Q
E
T
G
V
I
D
G
F
S
A
V
P
Y
I
H
G
-
F
S
W
Y
E
A
L
S
-
S
Y
Q
--
L
P
V
H
L
E
N
D
A
N
C
V
G
L
S
E
L
L
A
H
P
--
E
L
E
N
A
A
C
V
V
I
G
T
G
I
G
G
A
M
I
I
N
G
R
L
H
R
G
R
H
G
L
G
G
E
F
G
Y
M
T
T
L
A
P
-------------------
A
E
K
------------
L
N
N
W
S
Q
L
A
S
-----
T
G
N
-
M
V
R
Y
V
I
E
K
S
G
H
-----------------------------------
T
D
W
D
G
R
K
I
Y
Q
E
A
A
A
G
N
I
L
C
Q
E
A
I
E
R
--
M
N
R
N
L
A
Q
G
L
L
N
I
Q
Y
L
I
D
P
G
V
I
S
L
G
G
S
I
S
Q
-
N
--
P
D
F
I
-
Q
G
V
K
K
A
V
E
D
F
V
------
D
A
Y
EEYT
V
A
P
----
V
I
Q
A
C
T
Y
H
A
D
A
N
L
Y
G
A
L
V
N
W
L
Q
E
E
K
Q
---------
2
PsiBlast_PDB
72.97
34%
-106
- C1 -
2GUP
4
?
A:
[6-291]
----------------------------------------------------------------------------
I
A
T
I
D
I
G
G
T
G
I
K
F
A
S
L
T
P
D
G
K
I
----------
L
D
-
K
T
S
I
S
T
P
E
-
N
-
L
--
E
----
D
----
L
L
A
----
W
L
D
Q
R
L
----
S
----
E
-
Q
-
D
--------
Y
S
G
----
I
A
M
S
V
P
G
A
V
N
Q
E
T
G
V
I
D
G
F
S
A
V
P
Y
I
H
G
-
F
S
---
W
Y
E
A
L
S
S
YQ
L
P
V
H
L
E
N
D
A
N
C
V
G
L
S
E
--
L
L
A
H
P
E
L
E
N
A
A
C
V
V
I
G
T
G
I
G
G
A
M
I
I
N
G
R
L
H
R
G
R
H
G
L
G
G
E
F
G
Y
M
T
T
L
A
P
A
------------
E
K
----
L
N
N
------------
W
S
Q
L
A
S
T
G
N
-----
M
V
----
R
Y
V
I
E
K
S
G
H
-----------------------------------
T
D
W
D
G
R
K
I
Y
Q
E
A
A
A
G
N
I
L
C
Q
E
A
I
E
R
--
M
N
R
N
L
A
Q
G
L
L
N
I
Q
Y
L
I
D
P
G
V
I
S
L
G
G
S
I
S
Q
-
N
--
P
D
F
I
-
Q
G
V
K
K
A
V
E
D
F
V
D
A
Y
EEY
T
------
V
A
P
----
V
I
Q
A
C
T
Y
H
A
D
A
N
L
Y
G
A
L
V
N
W
L
Q
E
E
K
Q
---------
45
HHSearch
69.16
23%
-113
- C1 -
2AP1
1
NAGK_SALTY
A:
[25-326]
---------------------------------------------------------------------------
M
Y
Y
G
F
D
I
G
G
T
K
I
A
L
G
V
F
D
S
T
R
R
L
---------
Q
W
E
-
K
R
V
P
T
P
H
T
-
S
-
Y
--
S
----
A
----
F
L
D
----
A
V
C
E
L
V
E
E
A
D
Q
----
R
-
F
G
V
--------
K
G
S
----
V
G
I
G
I
P
G
M
P
E
T
E
D
G
T
L
Y
A
A
N
-
V
P
A
A
S
G
-
K
P
L
R
A
D
L
S
A
R
L
D
--
R
D
V
R
L
D
N
D
A
N
C
F
A
L
S
E
A
W
D
D
E
F
T
Q
Y
P
L
V
M
G
L
I
L
G
T
G
V
G
G
G
L
V
L
N
G
K
P
I
T
G
Q
S
Y
I
T
G
E
F
G
H
M
R
L
P
V
D
A
L
T
L
M
GFDFPLRR
C
G
----
C
G
Q
------------
M
G
C
I
E
N
Y
L
S
-----
G
R
G
-
F
A
W
L
Y
Q
H
Y
Y
D
Q
------------------------------------
S
L
Q
A
P
E
I
I
A
L
W
E
Q
G
D
E
Q
A
H
A
H
V
E
R
--
Y
L
D
L
L
A
V
C
L
G
N
I
L
T
I
V
D
P
D
L
L
V
I
G
G
G
L
S
N
-
F
--
T
A
I
T
-
T
Q
L
A
E
R
L
P
R
H
L
------
L
PVA---
R
A
P
----
R
I
E
R
A
R
H
G
D
A
G
G
M
R
G
A
A
F
L
H
L
T
-------------
39
HHSearch
67.62
26%
-104
- C1 -
2QM1
5
?
A:
[6-324]
--------------------------------------------------------------------------
K
K
I
I
G
I
D
L
G
G
T
T
I
K
F
A
I
L
T
T
D
G
V
V
---------
Q
Q
K
-
W
S
I
E
T
N
I
L
E
D
-
G
--
K
H
I
V
P
S
----
I
I
E
----
S
I
R
H
R
I
----
D
L
Y
NM
K
-
K
E
D
--------
F
V
G
----
I
G
M
G
T
P
G
S
V
D
I
E
K
G
T
V
V
G
A
Y
N
L
N
W
-
T
T
V
Q
P
V
K
E
Q
I
E
S
A
L
G
--
I
P
F
A
L
D
N
D
A
N
V
A
A
L
G
E
R
W
K
G
A
G
E
N
N
P
D
V
I
F
I
T
L
G
T
G
V
G
G
G
I
V
A
A
G
K
L
L
H
G
V
A
G
C
A
G
E
V
G
H
V
T
V
D
P
N
G
FD----------
C
T
----
C
G
K
------------
R
G
C
L
E
T
V
S
S
-----
A
T
G
-
V
V
R
V
A
R
H
L
S
E
E
-----------
F
AGDS
E
L
K
Q
A
I
D
D
--
G
--------
Q
D
V
S
S
K
D
V
F
E
F
A
E
K
G
D
H
F
A
L
M
V
V
D
R
--
V
C
F
Y
L
G
L
A
T
G
N
L
G
N
T
L
N
P
D
S
V
V
I
G
G
G
V
S
A
-
A
G-
E
F
L
R
-
S
R
V
E
K
Y
F
Q
E
F
T
------
F
P
Q
V
R
--
N
S
T
----
K
I
K
L
A
E
L
G
N
E
A
G
V
I
G
A
A
S
L
A
L
Q
F
S
K
----------
36
HHSearch
67.26
29%
-103
- C1 -
3VGL
4
?
A:
[3-313]
---------------------------------------------------------------------------
L
T
I
G
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
---------
L
S
T
-
F
K
V
A
T
P
P
--
T
-
A
--
E
----
G
----
I
V
D
----
A
I
C
A
A
V
A
G
A
-
S
----
E
-
G
H
D
--------
V
E
A
----
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
D
W
-
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
--
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
LL----------
C
G
----
C
G
S
------------
Q
G
C
W
E
Q
Y
A
S
-----
G
R
A
-
L
V
R
Y
A
K
Q
R
A
N
A
-----------
T
PENA
A
V
L
L
G
L
G
DGS
V
--------
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
--
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
G-
E
L
V
L
-
D
P
I
R
K
S
F
R
R
W
L
------
I
GGEW
R
-
P
H
A
----
Q
V
L
A
A
Q
L
G
G
K
A
G
L
V
G
A
A
D
L
A
R
Q
G
------------
43
HHSearch
67.04
26%
-112
- C1 -
1Z05
7
?
A:
[109-416]
---------------------------------------------------------------------------
Q
F
L
S
M
R
L
G
R
G
Y
L
T
I
A
L
H
E
L
G
G
E
V
---------
L
I
D
-
T
K
I
D
I
H
E
I
-
D
-
Q
--
D
----
D
V
L
A
R
L
L
F
----
E
I
E
E
F
F
----
Q
T
Y
A
A
Q
-
L
D
R
--------
V
T
S
----
I
A
I
T
L
P
G
L
V
N
S
E
Q
G
I
V
L
Q
M
P
H
Y
N
-
V
K
N
-
L
A
L
G
P
E
I
Y
K
A
T
G
--
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
S
Q
D
V
D
N
S
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
H
I
Q
I
D
P
Q
G
KR----------
C
H
----
C
G
N
------------
Y
G
C
L
E
T
V
A
S
-----
S
Q
A
-
I
R
D
Q
V
T
A
R
I
Q
A
-----------
G
E
P
S
CLAT-------
V
--------
E
E
I
S
I
E
D
I
C
A
A
A
A
D
G
D
P
L
A
V
D
V
I
Q
Q
--
L
G
R
Y
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
G
V
I
N
Q
-
A
K
-
S
I
L
Y
-
P
S
I
E
Q
C
I
R
E
Q
S
------
L
PVYH--
Q
D
L
----
K
L
V
E
S
R
F
Y
K
Q
A
T
M
P
G
A
A
L
I
K
Q
A
-------------
38
HHSearch
66.74
28%
-109
- C1 -
3VOV
3
?
A:
[1-299]
--------------------------------------------------------------------------
M
K
V
V
G
L
D
L
G
G
T
K
I
A
A
G
V
F
D
G
-
K
R
L
---------
L
S
K
-
V
V
V
P
T
P
K
E
-
G
-
G
--
E
----
R
----
V
A
E
A
L
A
E
A
A
E
R
A
E
----
R
E
---
A
-
G
V
R
--------
G
E
A
----
I
G
L
G
T
P
G
P
L
D
F
R
R
G
V
I
R
---
N
I
P
G
V
Q
D
-
F
P
I
R
R
I
L
E
E
A
T
G
--
R
P
V
F
L
E
N
D
A
N
A
A
A
L
A
E
H
H
L
G
A
A
Q
G
E
E
S
S
L
Y
L
T
V
S
T
G
I
G
G
G
V
V
L
G
G
R
V
L
R
G
E
R
G
Q
G
G
E
L
G
H
L
T
L
L
P
G
G
PA----------
C
G
----
C
G
L
------------
E
G
C
L
E
A
L
A
A
-----
G
R
A
-
L
E
R
D
A
T
Y
A
F
Q
R
------------------------------------
P
V
D
T
R
E
L
F
R
L
F
Q
A
G
D
P
K
A
E
R
L
V
L
Q
--
A
A
R
Y
V
G
I
G
L
A
S
L
V
K
A
F
D
P
G
V
V
V
L
G
G
G
V
A
L
-
N
AP
E
G
Y
W
-
E
A
L
L
E
A
Y
R
R
Y
L
------
Q
G
W
----
E
A
P
----
P
L
R
R
A
R
L
G
A
E
A
G
L
L
G
A
A
L
T
A
Y
L
E
V
K
D
---------
64
Fugue
65.92
24%
-108
- C1 -
1Z05
8
?
A:
[34-429]
D
H
I
K
Q
I
N
A
G
R
V
Y
K
L
I
D
Q
KGPIS
R
I
D
L
S
K
E
S
ELA
P
A
S
I
T
K
I
T
R
E
L
I
D
A
HLIHETT
V
Q
E
A
I
S
R
G
R
P
A
V
G
L
QTNNLG
W
Q
F
L
S
M
R
L
G
R
G
Y
L
T
I
A
L
H
E
L
G
G
E
V
---------
L
I
D
-
T
K
I
D
I
H
E
I
-
D
-
Q
--
D
----
D
----
V
L
A
----
R
L
L
F
E
I
----
E
----
E
-
F
F
Q
T
Y
A
AQLDR
V
T
S
----
I
A
I
T
L
P
G
L
V
N
S
E
Q
G
I
V
L
Q
M
P
H
Y
N
-
V
K
N
-
L
A
L
G
P
E
I
Y
K
A
T
G
--
L
P
V
F
V
A
N
D
T
R
A
W
A
L
A
E
K
L
F
G
H
S
Q
D
V
D
N
S
V
L
I
S
I
H
H
G
L
G
A
G
I
V
L
D
G
R
V
L
Q
G
R
H
G
N
I
G
E
L
G
H
I
Q
I
D
P
Q
G
KR----------
C
H
----
C
G
N
------------
Y
G
C
L
E
T
V
A
S
-----
S
Q
A
-
I
R
D
Q
V
T
A
R
I
Q
A
G
E
P
S
CLA----
T
--------------
V
--------
E
E
I
S
I
E
D
I
C
A
A
A
A
D
G
D
P
L
A
V
D
V
I
Q
Q
--
L
G
R
Y
L
G
A
A
I
A
I
V
I
N
L
F
N
P
E
K
I
L
I
G
G
V
I
N
Q
A
K
--
S
I
L
Y
-
P
S
I
E
Q
C
I
R
E
Q
S
------
L
------
P
V
Y
HQD
L
K
L
V
E
S
R
F
Y
K
Q
A
T
M
P
G
A
A
L
I
K
Q
A
L
Y
D
G
L
L
L
M
K
V
V
E
G
25
PsiBlast_CBE
63.91
31%
-110
- C1 -
3VGK
1
?
D:
[7-269]
-------------------------------------------------------------------------------
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
---------
L
S
T
F
K
V
A
T
P
P
T
A
-
E
-
G
IV
D
----
A
----
I
C
A
----
A
V
-
A
G
A
----
S
----
E
-
G
H
D
--------
V
E
A
----
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
--
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
------------
L
L
CGCG
S
Q
G
------------
C
W
E
Q
Y
A
S
G
R
-----
A
L
V
R
Y
A
K
Q
R
A
N
A
T
P
E
NAAVLLGLGDG
S
--------------
V
--------
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
--
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
--
G
E
L
V
-------------------------------------------------------------------
37
HHSearch
63.63
21%
-100
* C1 *
2AA4
1
NANK_ECOLI
A:
[1-289]
--------------------------------------------------------------------------
M
T
T
L
A
I
D
I
G
G
T
K
L
A
A
A
L
I
G
A
D
G
Q
I
---------
R
D
R
-
R
E
L
P
T
P
A
S
Q
T
-
P
--
E
----
A
----
L
R
D
----
A
L
S
A
L
V
----
S
----
P
L
Q
A
H
--------
A
Q
R
----
V
A
I
A
S
T
G
I
I
R
D
G
S
L
L
A
L
N
P
H
N
L
G
G
L
L
H
-
F
P
L
V
K
T
L
E
Q
L
T
N
--
L
P
T
I
A
I
N
D
A
Q
A
A
A
W
A
E
F
Q
A
L
D
-
G
D
I
T
D
M
V
F
I
T
V
S
T
G
V
G
G
G
V
V
S
G
C
K
L
L
T
G
P
G
G
L
A
G
H
I
G
H
T
L
A
D
P
H
G
PV----------
C
G
----
C
G
R
------------
T
G
C
V
E
A
I
A
S
-----
G
R
G
-
I
A
A
A
A
Q
G
E
L
A
-------------------------------------
G
A
D
A
K
T
I
F
T
R
A
G
Q
G
D
E
Q
A
Q
Q
L
I
H
R
--
S
A
R
T
L
A
R
L
I
A
D
I
K
A
T
T
D
C
Q
C
V
V
V
G
G
S
V
G
L
-
A
--
E
G
Y
L
-
A
L
V
E
T
Y
L
A
Q
E
P
------
A
A-----
F
H
V
----
D
L
L
A
A
H
Y
R
H
D
A
G
L
L
G
A
A
L
L
A
Q
G
E
------------
47
HHSearch
63.43
22%
-115
- C1 -
2HOE
2
?
A:
[87-375]
--------------------------------------------------------------------------
A
Y
V
L
G
I
E
V
T
R
D
E
I
A
A
C
L
I
D
A
S
M
N
I
---------
L
A
H
-
E
A
H
P
L
P
S
Q
-
S
D
R
--
E
----
E
T
L
N
V
M
Y
R
----
I
I
D
R
A
K
D
M
M
E
K
----
L
-
G
S
K
--------
L
S
A
----
L
T
V
A
A
P
G
P
I
D
T
E
R
G
I
I
I
D
P
R
N
F
P
-
L
S
Q
-
I
P
L
A
N
L
L
K
E
K
Y
G
--
I
E
V
W
V
E
N
D
A
D
M
G
A
V
G
E
K
W
Y
T
K
--
R
D
D
S
F
A
W
I
L
T
G
K
G
I
G
A
G
I
I
I
D
G
E
L
Y
R
G
E
N
G
Y
A
G
E
I
G
Y
T
R
V
F
N
G
N
--------------------
E
------------
Y
V
F
L
E
D
V
C
N
-----
E
N
V
-
V
L
K
H
V
L
S
-----------------------------------------
M
G
F
S
-
L
A
E
A
R
D
S
G
D
V
R
V
K
E
Y
F
D
D
--
I
A
R
Y
F
S
I
G
L
L
N
L
I
H
L
F
G
I
S
K
I
V
I
G
G
F
F
K
E
-
L
G-
E
N
F
L
-
K
K
I
K
I
E
V
E
T
H
L
------
L
Y
K
----
H
S
V
----
D
M
S
F
S
K
V
Q
E
P
V
I
A
F
G
A
A
V
H
A
L
E
N
Y
L
E
---------
14
PsiBlast_PDB
63.36
24%
-98
- C1 -
4DB3
5
NAGK_VIBVU
A:
[29-322]
-------------------------------------------------------------------------------
F
D
V
G
G
T
K
I
E
F
G
A
F
N
E
K
L
E
R
---------
V
A
T
-
E
R
V
P
T
P
T
D
-
D
-
Y
--
P
----
L
----
L
L
E
----
T
I
A
G
L
V
----
A
----
K
-
Y
D
Q
--------
E
F
A
C
E
G
K
I
G
L
G
L
P
G
M
E
D
A
D
D
A
T
V
-
L
T
V
N
V
P
A
A
K
G
-
K
P
L
R
A
D
L
E
A
K
I
G
--
R
S
V
K
I
E
N
D
A
N
C
F
A
L
S
E
A
W
D
E
E
L
Q
D
A
P
S
V
M
G
L
I
L
G
T
G
F
G
G
G
L
I
Y
E
G
K
V
F
S
G
R
N
N
V
A
G
E
L
G
H
M
R
L
P
L
D
A
------------
W
F
----
H
L
G
DNAPLLGCGCGK
K
G
C
L
D
S
Y
L
S
-----
G
R
G
-
F
E
L
L
Y
A
H
Y
Y
G
------------------------------------
E
E
K
K
A
I
D
I
I
K
A
N
A
A
G
D
E
K
A
A
E
H
V
E
R
--
F
M
E
L
L
A
I
C
F
G
N
I
F
T
A
N
D
P
H
V
V
A
L
G
G
G
L
S
N
-
F
--
E
L
I
Y
-
E
E
M
P
K
R
V
P
K
Y
L
------
L
SV
A
---
K
C
P
----
K
I
I
K
A
K
H
G
D
S
G
G
V
R
G
A
A
F
-----------------
40
HHSearch
63.33
18%
-104
- C1 -
1Z6R
1
MLC_ECOLI
A:
[86-396]
---------------------------------------------------------------------------
H
Y
L
S
L
R
I
S
R
G
E
I
F
L
A
L
R
D
L
S
S
K
L
---------
V
V
E
-
E
S
Q
E
L
A
L
K
-
D
-
D
--
L
P
L
L
D
R
----
I
I
S
----
H
I
D
Q
F
F
----
I
R
HQK
K
-
L
E
R
--------
L
T
S
----
I
A
I
T
L
P
G
I
I
D
T
E
N
G
I
V
H
R
M
P
F
Y
E
D
V
K
E
-
M
P
L
G
E
A
L
E
Q
H
T
G
--
V
P
V
Y
I
Q
H
D
I
S
A
W
T
M
A
E
A
L
F
G
A
S
R
G
A
R
D
V
I
Q
V
V
I
D
H
N
V
G
A
G
V
I
T
D
G
H
L
L
H
A
G
S
S
S
L
V
E
I
G
H
T
Q
V
D
P
Y
G
KR----------
C
Y
----
C
G
N
------------
H
G
C
L
E
T
I
A
S
-----
V
D
S
-
I
L
E
L
A
Q
L
R
L
N
Q
-----------
S
MSSMLH--------
G
--------
Q
P
L
T
V
D
S
L
C
Q
A
A
L
R
G
D
L
L
A
K
D
I
I
T
G
--
V
G
A
H
V
G
R
I
L
A
I
M
V
N
L
F
N
P
Q
K
I
L
I
G
S
P
L
S
K
-
A
A-
D
I
L
F
-
P
V
I
S
D
S
I
R
Q
Q
A
------
L
PAYS--
Q
H
I
----
S
V
E
S
T
Q
F
S
N
Q
G
T
M
A
G
A
A
-
L
V
K
D
A
M
Y
N
---------
4
PsiBlast_PDB
62.61
27%
-91
- C1 -
2QM1
5
?
A:
[7-321]
---------------------------------------------------------------------------
K
I
I
G
I
D
L
G
G
T
T
I
K
F
A
I
L
T
T
D
G
V
V
Q
Q
K
W
S
I
E
T
N
I
L
E
-
D
G
K
H
I
V
P
S
-
I
-
I
--
E
----
S
----
I
R
H
----
R
I
D
L
Y
N
----
M
----
K
-
K
E
D
--------
F
V
G
----
I
G
M
G
T
P
G
S
V
D
I
E
K
G
T
V
V
G
A
Y
N
L
N
W
T
T
V
-
Q
P
V
K
E
Q
I
E
S
A
L
G
--
I
P
F
A
L
D
N
D
A
N
V
A
A
L
G
E
R
W
K
G
A
G
E
N
N
P
D
V
I
F
I
T
L
G
T
G
V
G
G
G
I
V
A
A
G
K
L
L
H
G
V
A
G
C
A
G
E
V
G
H
V
T
V
D
-
P
N
------------
G
F
DC--
T
C
G
------------
K
R
G
C
L
E
T
V
S
S
A
T
G
V
V
R
V
-
A
R
H
L
S
E
E
F
A
G
D
-----------
S
--------------
E
L
K
Q
A
I
D
D
G
Q
D
V
S
S
K
D
V
F
E
F
A
E
K
G
D
H
F
A
L
M
V
V
D
R
V
C
F
Y
L
G
L
A
T
G
--
N
L
G
N
T
L
N
P
D
S
V
V
I
G
G
G
V
S
A
-
A
--
G
E
F
L
R
S
R
V
E
K
Y
F
Q
E
F
T
------
F
P
Q
V
R
--
N
S
T
----
K
I
K
L
A
E
L
G
N
E
A
G
V
I
G
A
A
S
L
A
L
Q
-------------
26
PsiBlast_CBE
62.46
31%
-109
- C1 -
3VGK
1
?
C:
[7-269]
-------------------------------------------------------------------------------
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
---------
L
S
T
F
K
V
A
T
P
P
T
A
-
E
-
G
IV
D
----
A
----
I
C
A
----
A
V
-
A
G
A
----
S
----
E
-
G
H
D
--------
V
E
A
----
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
--
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
------------
L
L
CGCG
S
Q
G
------------
C
W
E
Q
Y
A
S
G
R
-----
A
L
V
R
Y
A
K
Q
R
A
N
A
T
P
E
NAAVLLGLGDG
S
--------------
V
--------
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
--
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
--
G
E
L
V
-------------------------------------------------------------------
23
PsiBlast_CBE
62.28
31%
-109
- C1 -
3VGK
1
?
F:
[7-269]
-------------------------------------------------------------------------------
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
---------
L
S
T
F
K
V
A
T
P
P
T
A
-
E
-
G
IV
D
----
A
----
I
C
A
----
A
V
-
A
G
A
----
S
----
E
-
G
H
D
--------
V
E
A
----
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
--
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
------------
L
L
CGCG
S
Q
G
------------
C
W
E
Q
Y
A
S
G
R
-----
A
L
V
R
Y
A
K
Q
R
A
N
A
T
P
E
NAAVLLGLGDG
S
--------------
V
--------
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
--
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
--
G
E
L
V
-------------------------------------------------------------------
21
PsiBlast_CBE
62.16
31%
-106
- C1 -
3VGK
1
?
H:
[7-269]
-------------------------------------------------------------------------------
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
---------
L
S
T
F
K
V
A
T
P
P
T
A
-
E
-
G
IV
D
----
A
----
I
C
A
----
A
V
-
A
G
A
----
S
----
E
-
G
H
D
--------
V
E
A
----
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
--
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
------------
L
L
CGCG
S
Q
G
------------
C
W
E
Q
Y
A
S
G
R
-----
A
L
V
R
Y
A
K
Q
R
A
N
A
T
P
E
NAAVLLGLGDG
S
--------------
V
--------
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
--
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
--
G
E
L
V
-------------------------------------------------------------------
11
PsiBlast_PDB
62.03
31%
-108
- C1 -
3VGM
3
?
A:
[7-269]
-------------------------------------------------------------------------------
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
---------
L
S
T
F
K
V
A
T
P
P
T
A
-
E
-
G
I
V
D
----
A
----
I
C
A
----
A
V
-
A
G
A
----
S
----
E
-
G
H
D
--------
V
E
A
----
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
--
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
------------
L
L
CGCG
S
Q
G
------------
C
W
E
Q
Y
A
S
G
R
-----
A
L
V
R
Y
A
K
Q
R
A
N
A
T
P
E
NA
A
V
L
L
G
L
G
DG
S
--------------
V
--------
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
--
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
--
G
E
L
V
-------------------------------------------------------------------
9
PsiBlast_PDB
61.96
31%
-107
- C1 -
3VGK
1
?
A:
[7-269]
-------------------------------------------------------------------------------
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
---------
L
S
T
F
K
V
A
T
P
P
T
A
-
E
-
G
I
V
D
----
A
----
I
C
A
----
A
V
-
A
G
A
----
S
----
E
-
G
H
D
--------
V
E
A
----
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
--
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
------------
L
L
CGCG
S
Q
G
------------
C
W
E
Q
Y
A
S
G
R
-----
A
L
V
R
Y
A
K
Q
R
A
N
A
T
P
E
NA
A
V
L
L
G
L
G
DG
S
--------------
V
--------
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
--
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
--
G
E
L
V
-------------------------------------------------------------------
10
PsiBlast_PDB
61.32
31%
-101
- C1 -
3VGL
4
?
A:
[7-269]
-------------------------------------------------------------------------------
V
D
I
G
G
T
K
I
A
A
G
V
V
D
E
E
G
R
I
---------
L
S
T
F
K
V
A
T
P
P
T
A
-
E
-
G
I
V
D
----
A
----
I
C
A
----
A
V
-
A
G
A
----
S
----
E
-
G
H
D
--------
V
E
A
----
V
G
I
G
A
A
G
Y
V
D
D
K
R
A
T
V
L
F
A
P
N
I
-
D
W
R
H
-
E
P
L
K
D
K
V
E
Q
R
V
G
--
L
P
V
V
V
E
N
D
A
N
A
A
A
W
G
E
Y
R
F
G
A
G
Q
G
H
D
D
V
I
C
I
T
L
G
T
G
L
G
G
G
I
I
I
G
N
K
L
R
R
G
R
F
G
V
A
A
E
F
G
H
I
R
V
V
P
D
G
------------
L
L
CGCG
S
Q
G
------------
C
W
E
Q
Y
A
S
G
R
-----
A
L
V
R
Y
A
K
Q
R
A
N
A
T
P
E
NA
A
V
L
L
G
L
G
DG
S
--------------
V
--------
D
G
I
E
G
K
H
I
S
E
A
A
R
Q
G
D
P
V
A
V
D
S
F
R
E
--
L
A
R
W
A
G
A
G
L
A
D
L
A
S
L
F
D
P
S
A
F
I
V
G
G
G
V
S
D
-
E
--
G
E
L
V
-------------------------------------------------------------------