@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2840: (2016-04-07 )
VEMDPNTDLSSVTRPRATPVLTTFQFDSGKVGHIWTTFSEDQIDLNFACPEVLYKMIDVLMFYLEEGAEYVRLDAVGFMWKVPGTSSIHLEETHEIVKLFRDLVDIAAPGTIIITETNVPHVDNISYFGNGEKEAHMVYQFPLPPLVLHAIHHGNAKFLRNWAKNLELPEGKRTFFNFLASHDGIGLNPVRGIIPEAEILALVNDLEEEGALVSYKQNPDGSKSPYEINVTYMDALSKQADTDDLRLARFLVAHAVLMSIPGVPAVYVQSILGSRNDYLGVEATSHNRSINRKKYDLAEITAELEQRGSLRKATYDALTKLISTRKAESLFHPEIPMEVLESTAELFVVKRSSDAESIILIHNLSEKEVSYSLDSGVYTNLYKGSTVTGSDSIKLSGYEFCWLKTKNYREEQK
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50-........----.60....--....70........80.....----------------.------------..90........100.......110.......120-.......130-.........140.-......150..---------.....160.......--.-170.......180.......190..------....-----.200.......210---.........-220..---...----..230--------..--------.....240-----.........250.......260.......270.....---..280---.---.---------.....------------------------290.......300-..-------------------......310.......320.......330........340.--.......350.......360......---.370..-----.--------.---...--380--.....-.----.---..390--.......400.......410.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEMDPNTD
L
S
SVTRPRAT
P
V
L
T
T
F
QFDSGKV
G
H
I
W
T
TFSE
D
Q
I
D
LNFA
C
P
--
E
V
L
Y
K
M
I
D
----
V
L
M
F
Y
L
E--EGA
E
Y
V
R
L
DAV
G
F
M
W
KVPGT
S
----------------
S
------------
I
H
L
E
E
T
H
E
I
V
K
L
F
R
D
L
V
D
IAAP
G
T
I
I
I
TETNVPHV-DN
I
S
YFGN---GE
K
E
A
H
M
V
Y
QFPL-
P
P
L
V
L
H
A
IHHG---------
N
A
K
F
L
R
N
-
W
A
KNLEL--P-E
G
K
R
T
F
F
N
F
L
A
SHDGIGLN
P
V
RGII------
P
E
A
E
-----
I
L
A
L
V
N
D
L
E
EEG-----
A
L
V
S
Y
KQNP-DGSKS---
P
Y
E
----
I
N
V
T
Y
--------
M
D
--------
A
LSKQA-------D
T
D
D
L
R
L
A
R
F
L
V
A
H
A
V
L
M
SIPG
V
P
A
V
Y
V
Q
S
I
LGSRND---
Y
L
G
V
E
---A---T---------SHNRS------------------------IN
R
K
K
Y
D
L
A
E
I
T
--
A
E
-------------------
L
E
QRGS
L
R
K
A
T
Y
D
A
L
T
K
L
I
S
T
R
K
A
E
SLF-HPEI
P
M
E
V
L
E
-
S
--
T
A
E
L
F
V
V
KRSSDA
E
S
I
I
L
I
HNLSE
K
E
---
V
S
Y
SLD-----S--------G---
V
Y
T
--
N
----LYKGS-T----V---TGSD
S
--
I
K
LSG
Y
E
F
C
W
L
KTKNYREEQK
24
HHSearch
85.07
22%
-94
- C2 -
1G5A
2
AMYS_NEIPO
A:
[242-627]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
R
W
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
E
A
I
V
H
P
D
-
Q
V
V
Q
Y
I
G
Q
-----
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
-
A
L
T
Y
R
H
N
L-
P
-
E
H
-
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
F
A
D
E
D
A
A
Y
L
GIS
G
Y
D
H
-----
R
Q
F
L
N
R
F
F
V
N
R
F
DGSFA
R
G
V
P
F
Q
Y
N
P
-
S
T
--
G
---
D
C
R
----
V
S
G
T
A
--------
A
A
--------
L
V
G
L
A
Q
--------
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
---
D
D
W
S
Q
---
D
SNK
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
L
Y
---
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
-
R
L
V
T
F
N
T
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
---
Q
T
V
T
A
H
-----
T
LQAMP---
F
---
K
A
H
--
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
--------
20
PsiBlast_PDB
84.25
23%
-87
- C2 -
4FLO
4
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
P
C
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
E
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
QTV
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
25
HHSearch
84.15
24%
-90
- C2 -
3CZG
1
?
A:
[228-638]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
F
T
W
V
D
D
T
A
Q
W
M
W
T
T
F
Y
P
Y
Q
W
D
L
N
W
S
N
P
--
A
V
F
G
D
M
A
L
----
A
M
L
R
L
A
N
--
L
G
V
E
A
F
R
L
D
S
T
A
Y
L
W
K
R
I
G
T
D
----------------
C
------------
M
N
Q
S
E
A
H
T
L
L
V
A
L
R
A
V
T
D
I
V
A
P
A
V
V
M
K
A
E
A
I
V
P
M
T
-
Q
L
P
P
Y
F
G
S
GVD
E
G
H
E
C
H
L
A
Y
H
S
T
L
-
M
A
A
G
W
S
A
L
A
L
Q
---------
R
G
D
I
L
H
N
-
V
I
A
H
S
P
P
L-
P
-
R
-
H
C
A
W
L
S
Y
V
R
C
H
D
D
I
G
W
N
V
L
Q
H
E
A
------
C
G
N
A
AQPPF
S
L
R
D
V
A
R
F
Y
A
N
A
-----
V
----
P
-
G
S
-
Y
A
R
G
E
---
S
F
-G
V
H
G
T
N
G
M
A
--------
A
A
--------
L
A
G
I
Q
A
A
Q
E
A
GD
A
A
A
L
A
V
A
V
D
R
L
V
L
L
Y
A
I
A
L
A
M
P
G
V
P
L
I
Y
M
G
D
E
L
A
M
V
N
D
---
P
G
Y
R
D
DPH
R
---
Q
---------
H
E
G
R
W
------------------------
L
H
R
P
A
M
D
W
Q
L
A
A
---
Q
-------------------
R
H
D
A
K
S
L
S
G
T
V
Y
R
R
L
R
G
L
I
R
Q
R
A
A
L
G
A
L
-
A
A
D
Q
A
L
A
S
I
A
L
N
--
D
P
R
V
F
A
L
T
R
G
---
D
S
F
I
A
L
H
N
F
S
D
Q
L
---
L
D
V
E
L
A
-----
A
--------
I
GVD
G
W
T
--
L
L----------------------
S
--
I
V
L
P
P
Y
G
V
R
W
L
Q
R
G
-------
4
PsiBlast_PDB
84.02
23%
-82
- C2 -
4TVU
2
?
A:
[158-552]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
N
W
T
L
D
E
Q
A
G
K
Y
Y
W
H
R
F
F
A
S
Q
P
D
L
N
Y
D
N
P
--
K
V
V
E
E
L
H
G
----
A
A
R
F
W
L
D
--
L
G
L
D
G
F
R
V
D
A
V
P
Y
L
I
E
R
E
G
T
S
----------------
C
------------
E
N
L
P
E
T
H
E
I
L
K
G
F
R
A
M
V
D
R
E
Y
P
G
R
L
L
L
A
E
A
N
Q
W
P
E
-
E
V
V
E
Y
F
G
T
E--
A
E
P
E
F
H
M
C
F
N
F
P
V
-
M
P
R
L
Y
M
S
L
K
R
E
---------
D
T
S
S
I
R
E
-
I
M
G
R
L
P
K
--
I
-
P
S
F
G
Q
W
C
I
F
L
R
N
H
D
E
L
------------------------
T
L
E
M
V
T
D
--
D
E
R
-----
A
F
M
Y
A
A
Y
A
P
-
D
A
R
M
------
K
----
I
N
V
G
I
--------
R
R
--------
R
L
A
P
L
L
-------
D
N
D
R
R
R
I
E
---
L
L
N
T
V
L
L
A
L
P
G
S
P
V
L
Y
Y
G
D
E
I
G
M
G
D
D
----
L
G
L
P
---
D
---
R
---------
N
G
V
R
T
PMQWNAGTSGGFSTAQPSDCFFPP
I
Q
D
P
V
Y
G
F
G
R
V
N
V
Q
S
Q
-------------------
L
Q
D
P
S
S
L
L
K
W
T
----
A
R
Q
L
E
L
R
R
A
H
P
A
F
A
H
G
D
L
T
F
-
I
E
T
-
G
--
N
P
A
I
L
A
F
T
R
Q
Y
D
G
E
T
L
L
I
V
S
N
F
A
G
N
A
---
Q
A
G
L
L
D
-----
L
--------
A
---
P
F
V
--
G
R
A
P
V
T
L
S
G
A
-
S
PLPV
V
---
T
G
N
G
Q
Y
P
V
V
M
G
K
Y
D
Y
Y
W
L
R
---------
14
PsiBlast_PDB
83.66
23%
-87
- C2 -
1MW0
4
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
Q
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
G
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
12
PsiBlast_PDB
83.41
23%
-87
- C2 -
1MW3
3
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
E
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
19
PsiBlast_PDB
83.11
23%
-86
- C2 -
4FLQ
9
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
P
I
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
E
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
QTV
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
13
PsiBlast_PDB
83.09
23%
-88
- C2 -
1MVY
3
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
Q
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
G
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
10
PsiBlast_PDB
82.90
23%
-86
- C2 -
1MW1
2
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
E
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
9
PsiBlast_PDB
82.84
23%
-87
- C2 -
1JG9
3
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
E
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
7
PsiBlast_PDB
82.77
23%
-85
- C2 -
3UEQ
3
AMYS_NEIPO
A:
[243-630]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
E
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
11
PsiBlast_PDB
82.60
23%
-87
- C2 -
1MW2
3
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
E
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
8
PsiBlast_PDB
82.58
23%
-87
- C2 -
1G5A
2
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
E
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
15
PsiBlast_PDB
82.56
23%
-87
- C2 -
1S46
1
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
Q
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
G
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
QTV
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
16
PsiBlast_PDB
82.06
23%
-86
- C2 -
1ZS2
3
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
Q
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
G
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
18
PsiBlast_PDB
81.03
23%
-89
* C2 *
4FLR
19
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
P
L
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
E
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
QTV
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
17
PsiBlast_PDB
81.00
23%
-88
- C2 -
1JGI
1
AMYS_NEIPO
A:
[239-626]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
E
D
G
R
W
--
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
Q
A
I
V
-
H
P
-
D
Q
V
V
Q
Y
-
I
---
G
Q
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
A
L
T
Y
R
H
N
L
--
P
-
E
-
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
----
F
A
------
D
E
D
A
-----
A
Y
L
G
I
S
G
Y
D
H
R
Q
-----
F
L
N
R
F
F
V
N
R
F
D
G
S
F
A
R
G
V
P
F
Q
----
Y
N
P
S
T
--------
G
D
C
R
V
S
G
T
A
A
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
DDW
S
Q
D
S
N
---
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
E
A
-
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
N
---
A
L
L
A
F
G
N
F
S
E
Y
P
Q
T
V
T
A
H
T
L
Q
-----
A
--------
M
---
P
F
K
A
H
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
---------
32
HHSearch
79.62
21%
-88
- C2 -
3WY2
5
?
A:
[151-538]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
W
T
F
D
S
R
R
Q
Q
Y
Y
L
H
N
F
L
T
S
Q
P
D
V
N
F
H
H
P
--
E
A
R
Q
A
Q
L
D
----
N
M
R
F
W
L
D
--
L
G
V
D
G
F
R
L
D
T
V
N
F
Y
F
H
D
A
E
L
R
D
N
P
P
VPKGEAKTLGAP
E
ANPYTWQRHVYD
L
S
R
P
E
N
L
D
F
L
K
D
L
R
A
L
M
D
-
E
Y
P
G
T
T
T
V
G
E
I
G
D
D
N
P
L
E
R
M
A
E
Y
T
A
---
G
G
D
K
L
H
M
A
Y
T
F
D
L
-
L
N
M
P
------
H
---------
S
A
S
Y
L
R
E
-
V
I
E
R
F
Q
R
--
L
-
A
G
D
A
W
P
C
W
A
T
S
N
H
D
V
V
--------------------------
R
S
A
T
R
W
G
A
D
----------------------------------------------------------------------
E
D
P
H
A
Y
P
K
V
M
L
A
V
L
F
S
L
R
G
S
V
C
L
Y
Q
G
E
E
L
G
L
P
E
A
---
D
V
P
F
E
R--
I
Q--
D
P
Y
G
K
V
LWPE
F
K
G
R
D
------------------------
G
C
R
T
P
M
P
W
T
D
G
E
--
Q
G
GFSPVEPWLPME
A
R
H
L
E
L
A
V
S
R
Q
Q
D
D
P
N
A
T
L
N
T
V
R
A
L
L
A
F
R
R
S
H
P
A
L
-
F
D
G
-
D
L
S
L
V
D
-
V
--
G
D
D
L
L
G
F
T
R
Q
K
G
D
E
T
L
L
C
V
F
N
L
T
G
Q
E
---
Q
Q
T
T
L
P
-----
V
--------
E
---
V
A
S
--
D
----
L
P
V
A
H
F
T
----
A
T
--
R
D
G
S
T
--
L
T
L
P
A
Y
Q
A
A
F
M
Q
V
A
-------
47
Fugue
78.79
20%
-68
- C2 -
1G5A
3
AMYS_NEIPO
A:
[1-628]
SPN
S
Q
Y
L
K
T
R
I
L
DIYT
P
E
Q
R
A
G
I
E
K
S
E
D
W
R
Q
F
S
R
R
M
D
T
H
F
P
K
L
M
N
E
L
D
S
V
YGNNEA
L
L
P
M
L
E
M
L
L
A
Q
A
W
Q
S
Y
S
Q
RN
S
S
L
K
D
I
D
I
A
R
E
N
N
PDWILSNK
Q
V
G
G
V
C
Y
VDLFAGD
L
K
G
L
K
D
K
I
P
Y
F
Q
E
L
GLT
Y
L
H
L
M
PL
F
K
C
P
E
GKSDGGYAVSSYRDVNPALGT
I
G
D
L
R
E
V
I
A
A
L
H
E
A
G
I
S
A
V
V
D
FIFNHTSNEH
E
W
A
Q
R
C
A
A
GDPLFDNF
Y
Y
I
F
P
D
R
R
M
P
D
Q
Y
D
R
T
L
R
E
I
F
P
D
Q
H
P
G
G
F
S
Q
L
E
D
G
R
W
V
W
T
T
F
N
S
F
Q
W
D
L
N
Y
S
N
P
--
W
V
F
R
A
M
A
G
----
E
M
L
F
L
A
N
--
L
G
V
D
I
L
R
M
D
A
V
A
F
I
W
K
Q
M
G
T
S
----------------
C
------------
E
N
L
P
Q
A
H
A
L
I
R
A
F
N
A
V
M
R
I
A
A
P
A
V
F
F
K
S
E
A
I
V
H
P
D
-
Q
V
V
Q
Y
I
G
Q
-----
D
E
C
Q
I
G
Y
N
P
L
Q
-
M
A
L
L
W
N
T
L
A
T
R
---------
E
V
N
L
L
H
Q
-
A
L
T
Y
R
H
N
--
L
-
P
E
H
T
A
W
V
N
Y
V
R
S
H
D
D
I
G
W
T
F
A
D
E
D
A
------
A
Y
L
G
-----
I
S
G
Y
D
H
R
Q
F
L
N
R
-----
F
F
V
N
R
F
D
G
S
-
F
A
R
G
V
---
P
F
Q
----
Y
N
P
S
T
G
D
C
R
V
S
G
T
A
A
--------
A
L
V
G
L
A
-------
Q
D
D
P
H
A
V
D
R
I
K
L
L
Y
S
I
A
L
S
T
G
G
L
P
L
I
Y
L
G
D
E
V
G
T
L
N
D
---
D
D
W
S
Q
DSN
K
---
S
---------
D
D
S
R
W
------------------------
A
H
R
P
R
Y
N
-
E
A
L
Y
--
A
Q
-------------------
R
N
D
P
S
T
A
A
G
Q
I
Y
Q
D
L
R
H
M
I
A
V
R
Q
S
N
P
R
F
-
D
G
G
R
L
V
T
F
N
T
-
N
--
N
K
H
I
I
G
Y
I
R
N
---
N
A
L
L
A
F
G
N
F
S
E
Y
P
---
Q
T
V
T
A
H
TLQAM
P
--------
F
---
K
A
H
--
D
----
L
I
G
G
K
-
T
----
V
---
S
L
N
Q
D
--
L
T
L
Q
P
Y
Q
V
M
W
L
E
I
A
-------
35
HHSearch
75.97
18%
-98
- C2 -
1JI1
-
NEPU1_THEVU
A:
[291-636]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
P
W
Y
N
Y
Y
T
F
Y
T
W
P
D
S
Y
A
S
F
L
G
F
N
S
L
P
K
L
N
Y
G
N
S
GS
A
V
R
G
V
I
Y
N
NSNS
V
A
K
T
Y
L
N
PP
Y
S
V
D
G
W
R
L
D
A
A
Q
Y
V
D
A
N
G
N
N
------------------------------
G
S
D
V
T
N
H
Q
I
W
S
E
F
R
N
A
V
K
G
V
N
S
N
A
A
I
I
G
E
Y
W
G
N
A
N
----
P
W
T
A
Q
----
G
N
Q
W
D
A
A
T
N
F
D
G
F
T
Q
P
V
S
E
W
I
T
G
K
DYQN
N
S
A
S
I
S
T
T
Q
F
D
S
-
W
L
R
G
T
R
A
N
Y
P
T
N
V
Q
Q
S
M
M
N
F
L
S
N
H
D
I
T
--------------------------
R
F
A
T
R
S
G
G
-------------------------------------------------------------------------
D
L
W
K
T
Y
L
A
L
I
F
Q
M
T
Y
V
G
T
P
T
I
Y
Y
G
D
E
Y
G
M
Q
G
G
---
A
D
P
------------------------------------------------
D
N
R
R
S
F
D
W
S
Q
A
T
--
P
---------------------------
S
N
S
A
V
A
L
T
Q
K
L
I
T
I
R
N
Q
Y
P
A
L
-
R
T
G
-
S
F
M
T
L
I
-
T
DD
T
N
K
I
Y
S
Y
G
R
F
D
N
V
N
R
I
A
V
V
L
N
N
D
S
V
S
---
H
T
V
N
V
P
-----
V
WQLSMPNG
S
---
T
V
T
--
D
----
K
I
T
G
H
-
S
----
Y
T
V
Q
N
G
M
V
T
--
V
A
V
D
G
H
Y
G
A
V
L
A
---------