@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
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Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0008: (2015-11-27 )
MNIIELFSQNKVVRTWHSGLVTNSRQLVMGFSGASKAIAIASAYEKLSKKIMVVTATQTDSDKLSSDISSLIGEDNVYQFFADDVPAAEFIFSSLDKSISRLSALRFLKDPEKNGVLITSISGLRLLLPNPEVFSKSQYKFEIGQECYLDKLCKNLVNLGYQKVSQVFSPGEFSQRGDILDIFEMTQEYPYRLEFFGDEIDGIRQFDIDTQKSLKQLESVQISPADDIILQDADFERAKKKLEGYLVTASEVQRTYLSEVLSTTENHFKHSDIRRFLSIFYEKEWGILDYIPEGTPLFVDDFQKIVDRNAKLDLEIASLLTEDLQQGKSHSSLNYFSDPYKQLRQYQPATFFSNFHKGLGNLKFDKLHHFTQYGMQEFFNQFPLLVDEINRYKKSGATVLLQVDSQKGLNLLQENLKEYGLDLIISDKNDIVQKESQLIVGHLSNGFYFADEKIVLITEREIYHRRVKRKIRRSNISNAERLKDYNELSVGDYVVHNVHGVGKFLGIETIEIQGIHRDYLTIQYQNADRISIPVEQIELLTKYVSADGKEPKINTLNDGRFKKAKQRVAKQVEDIADDLLKLYAERSQLQGFAFSPDDNMQNDFDNDFAYVETEDQLRSIKEIKQDMEGNRPMDRLLVGDVGFGKTEVAMRAAFKAVNDHKQVVVLVPTTVLAQQHFENFKERFSNYPVTVDVLSRFRSKKEQTDTLKRLSKGQVDIIIGTHRLLSQDVVFSDLGLIVIDEEQRFGVKHKEKLKELKTKVDVLTLTATPIPRTLHMSMLGIRDLSVIETPPTNRYPVQTYVLETNPGLVREAIIREIDRGGQVFYVYNKVDTIDQKVSELQELVPEASIGFVHGQMSEIQLENTLIDFINGDYDVLVATTIIETGVDISNVNTLFVENADHMGLSTLYQLRGRVGRSNRIAYAYLMYRPDKVLTEISEKRLDAIKGFTELGSGFKIAMRDLSIRGAGNILGASQSGFIDSVGFEMYSQLLEQAIATKQGKSLIRQKGNAELALQIDAYLPAEYISDERQKIEIYKRIRELETRADYEALQDELIDRFGEYPDQVAYLLEIGLLKAYLDLAFTELVERKGNEISILFEKASLKYFLTQDYFEALSKTQLKARISETNGKMEVVFNIKHKKNYEIIEELLKFAECFIEIKSRKPVEE
Atome Classification :
(20 SA)
.........10........20.-.......30.........40.......-.50........60........70........80------------.........90..-......100........110.......120.......130.......140.......150.......160.......170.......180....-...190.......200.......210.......220.......230.......240.......250.------------......260.......270....---...280..--...-...290......-.-300.......----------.310.......320.-----..-..--.--.330.......340.-.....--.350...---....360...--..-....-----370......------.380.......390-...-....400.......410.......420...-....-------------.430..--.....440.......450.......460.......470--.--.--.......480....------...490-------........500.......510.......520.......530.......540.......550.......560.......570.......580.......590.---......600.......-----610........620.......630.......640.......650......---.--------660.......670.......680....-.-.-.---690-.........700.......710.........720.....------.----------.730.......740.....-----.-----------------.------750---.------.....-----------...760.......770.......780.--.--..--....----.--790--..---.......800...-.---------.----...810....--.---..820.......830----------------------........840-------------------..-..--------....850.......860.......870.......880--.........890........900----....--.-----------...910.......----920....--...930.......940.......950.......960.......970.......980.......990..-..-...1000---.....---...1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130..-....1140......1150......1160..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
N
I
I
E
L
FSQN
K
V
V
R
T
W
HSGLVT-NS
R
Q
L
V
M
G-FSGAS
K
A
I
A
I
A
S
A
Y
E
K
L
S-K
K
I
M
V
V
T
ATQT
D
S
D
K
L
S
S
D
I
S
S
L
IGED
N
V
Y
Q
F
-------------FADDV
P
A
A
E
F
I
F
S
-
S
L
D
K
S
I
S
-
R
L
S
A
L
R
F
LKDPEKN
G
V
L
I
T
SIS
G
L
R
L
LLP
N
P
E
VFSK
S
Q
Y
K
F
EIG
Q
E
C
Y
L
D
K
L
C
K
N
L
V
N
L
G
Y
Q
K
V
S
Q
VFSPGEFSQRGD
I
L
D
I
F
E
M
T
-
Q
EYP
Y
R
L
E
FFGDEID
G
I
R
QFDI
D
T
Q
K
S
L
K
Q
L
E
SVQISPAD
D
I
I
LQDA
D
F
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R
A
K
K
K
LE
G
Y
L
V
T
A
S
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V
Q
------------
R
T
Y
L
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L
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T
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NHF
K
H
S
D
I
R
R
F
---
L
S
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Y
-EK--EWG-
I
L
D
YIPEGTP
L
F
-
V
-
D
-
D
F
Q
K
I
V
DR----------NAKL
D
L
E
I
A
S
L
L
T
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D
-----
L
Q
-QG--K--SHSSLNYFS
D
P
Y
K
Q
L
-
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QYQ
P
--
A
T
F
F
S
N
F
---
H
K
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LG--NL
K
--
F
D
-
K
L
H
H
-----
F
T
Q
Y
G
M
Q
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F
------
F
N
QF
P
L
L
V
D
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I
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Y-KKS-G
A
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V
L
L
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VDSQK
G
L
N
L
L
Q
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N
L
K
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L
-
D
L
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-ISD
K
-------------
N
D
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--ES
Q
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HLSN
G
F
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AD
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K
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R
K
----
I
--
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--RSNIS
N
A
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R
L
K
D
Y
N------ELSV
G
--------
D
Y
V
V
H
NVHGVG
K
F
LG
I
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T
I
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Q
G
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Y
L
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YQNADRISI
P
V
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SADGKEPKINTLND
G
R
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K
K
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D
I
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D
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L
L
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QLQ
G
F
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---FSPDDNMQNDFDND
F
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-----
Y
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T
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D
Q
L
R
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MEGNR
P
M
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VGDVGF
G
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AVN---D--------H
K
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V
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---
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---
V
D
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-----
K
-----------------
H
------
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-----
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K
L
K
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K
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D
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L
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TATPIP
R
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S
M
LG--
I
--
R
--
D
L
--
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IE----T--P----PT---NRY
P
V
Q
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V
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G
L
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A
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---DRG
G
Q
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YNKV
D
-----------------------
T
I
D
Q
K
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L
Q
--------------------
E
L-VP--------EASI
G
F
VHGQ
M
S
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I
Q
L
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N
T
L
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INGDY
D
V
L
V
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----
I
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V
N
T
L
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VENADH-----M
G
L
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--
T
-----------
L
Y
Q
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GRVGRSN
R
----
I
A
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--YR
P
D
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F
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IRGAGNILGASQSG
F
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F
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M
Y
S
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L
L
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Q
A
I
-
A
T
-
K
Q
G
K
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-----
L
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QK---GN
A
E
L
A
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AYL
P
A
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IS
D
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RKGN
E
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L
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K
M
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F
N
I-KHKK
N
Y
E
I
I
E
E
L
L
K
F
A
E
C
F
I
E
IKSRKPVEE
54
Fugue
86.43
36%
-74
- C1 -
2EYQ
5
MFD_ECOLI
A:
[5-1150]
------
P
E
Q
Y
R
Y
T
L
P
V
K
A
G
E
-----
Q
R
L
L
G
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-
L
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A
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-------------
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---
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-----
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--------------------
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K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
-------
E
N
A
I
--
21
PsiBlast_CBE
82.39
37%
-79
- C1 -
2EYQ
5
MFD_ECOLI
B:
[14-1070]
--------------------
V
K
-
A
G
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
--
D
Q
M
V
M
N
-------------
L
A
D
W
E
T
L
P
Y
D
S
F
S
-
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
-
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
P
E
------------
H
I
Y
Q
Q
V
S
K
G
T
L
P
-----
A
G
I
E
Y
W
---
Q
P
L
F
F
S
E
P
--
L
P
P
-
L
F
S
Y
F
P
A
N
T
L
L
V
N
T
-
G
-
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
-
P
M
R
P
L
L
P
P
Q
SLW--
L
R
-
V
D
--
E
--
L
F
S
E
L
K
N
W
--
P
R
V
Q
L
-
K
T
E
H
L
--
P
T
K
A
A
N
--------
A
--
N
L
G
--
F
Q
-
K
L
P
D
-----
L
A
V
Q
A
Q
Q
----------
K
A
P
L
--
D
A
L
R
K
F
-
L
E
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
-
I
M
R
L
-------------
D
E
A
S
D
R
--
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
G
E
R
V
A
R
R
----
R
--
Q
DS
R
R
T
I
N
P
D
T
L
I
R
N
L
A
------
E
L
H
I
G
--------
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
---
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
-----
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
---
N
--------
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
-
W
-
P
-
V
---
R
---
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
--
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
------
D
----------
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
R
F
G
V
-----
R
-----------------
H
------
K
-----
E
------
R
I
K
A
M
-----------
R
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
G
--
M
--
R
--
D
L
--
S
I
I
A
----
T
--
P
----
P
A
---
R
R
L
A
V
K
T
F
V
-
R
E
Y
-
D
---------
S
----
M
V
V
R
E
A
I
L
R
E
--
I
---
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
-----------------------
N
I
Q
K
A
A
E
R
L
A
--------------------
E
L
-
V
P
--------
E
A
R
I
A
I
G
H
G
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
V
L
V
C
T
T
----
I
I
E
T
G
I
D
I
P
T
-
A
N
T
I
I
I
E
R
A
D
H
-----
F
G
L
A
--
Q
-----------
L
H
Q
L
R
G
R
V
G
R
S
H
H
----
Q
A
Y
A
W
L
L
--
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
-
K
A
G
R
E
PSLED
L
T
S
Q
Q
-----
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
A
E
K
N
H
V
N
P
A
W
L
I
G
L
L
Q
K
Q
P
Q
H
Y
R
L
D
G
P
T
R
L
K
F
I
Q
D
L
S
E
R
-
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
E
N
A
I
-----------
1
PsiBlast_PDB
81.34
37%
-75
- C1 -
2EYQ
5
MFD_ECOLI
A:
[14-1070]
--------------------
V
K
-
A
G
E
Q
R
L
L
G
E
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
--
D
Q
M
V
M
N
-------------
L
A
D
W
E
T
L
P
Y
D
S
F
S
-
P
H
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
-
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
P
E
------------
H
I
Y
Q
Q
V
S
K
G
T
L
P
-----
A
G
I
E
Y
W
---
Q
P
L
F
F
S
E
P
--
L
P
P
-
L
F
S
Y
F
P
A
N
T
L
L
V
N
T
-
G
-
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
-
P
M
R
P
L
L
P
P
Q
SLW--
L
R
-
V
D
--
E
--
L
F
S
E
L
K
N
W
--
P
R
V
Q
L
-
K
T
E
H
L
--
P
T
K
A
A
N
--------
A
--
N
L
G
--
F
Q
-
K
L
P
D
-----
L
A
V
Q
A
Q
Q
----------
K
A
P
L
--
D
A
L
R
K
F
-
L
E
T
F
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
Q
R
-
I
M
R
L
-------------
D
E
A
S
D
R
--
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
G
E
R
V
A
R
R
----
R
--
Q
DS
R
R
T
I
N
P
D
T
L
I
R
N
L
A
------
E
L
H
I
G
--------
Q
P
V
V
H
L
E
H
G
V
G
R
Y
A
G
M
T
T
L
E
A
G
G
I
T
G
E
Y
L
M
L
T
Y
A
N
D
A
K
L
Y
V
P
V
S
S
L
H
L
I
S
R
Y
A
G
G
A
E
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
L
D
I
Y
A
Q
R
A
A
K
E
G
F
A
---
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
-----
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
---
N
--------
H
K
Q
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
-
W
-
P
-
V
---
R
---
I
E
M
I
S
R
F
R
S
A
K
E
Q
T
Q
I
L
A
E
V
--
A
E
G
K
I
D
I
L
I
G
T
H
K
L
L
Q
S
------
D
----------
V
K
F
K
D
L
G
L
L
I
V
D
E
E
H
R
F
G
V
-----
R
-----------------
H
------
K
-----
E
------
R
I
K
A
M
-----------
R
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
S
G
--
M
--
R
--
D
L
--
S
I
I
A
----
T
--
P
----
P
A
---
R
R
L
A
V
K
T
F
V
-
R
E
Y
-
D
---------
S
----
M
V
V
R
E
A
I
L
R
E
--
I
---
L
R
G
G
Q
V
Y
Y
L
Y
N
D
V
E
-----------------------
N
I
Q
K
A
A
E
R
L
A
--------------------
E
L
-
V
P
--------
E
A
R
I
A
I
G
H
G
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
V
L
V
C
T
T
----
I
I
E
T
G
I
D
I
P
T
-
A
N
T
I
I
I
E
R
A
D
H
-----
F
G
L
A
--
Q
-----------
L
H
Q
L
R
G
R
V
G
R
S
H
H
----
Q
A
Y
A
W
L
L
--
T
P
H
P
K
A
M
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
D
L
G
A
G
F
A
L
A
T
H
D
L
E
I
R
G
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
S
L
Y
M
E
L
L
E
N
A
V
D
A
L
-
K
A
G
R
E
PSLED
L
T
S
Q
Q
-----
T
E
V
E
L
R
M
P
S
L
L
P
D
D
F
I
P
D
V
N
T
R
L
S
F
Y
K
R
I
A
S
A
K
T
E
N
E
L
E
E
I
K
V
E
L
I
D
R
F
G
L
L
P
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
G
I
R
K
L
E
G
N
E
K
G
G
V
I
E
F
A
E
K
N
H
V
N
P
A
W
L
I
G
L
L
Q
K
Q
P
Q
H
Y
R
L
D
G
P
T
R
L
K
F
I
Q
D
L
S
E
R
-
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
E
N
A
I
-----------
35
HHSearch
64.28
37%
-76
- C1 -
1GM5
2
?
A:
[351-740]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
I
E
G
K
L
A
E
E
F
I
K
S
L
P
-----
F
-
K
L
T
N
A
Q
K
R
A
H
Q
E
I
R
N
D
M
I
S
E
K
P
M
N
R
L
L
Q
G
D
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
N
Y
E
---
A
--------
G
F
Q
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
E
S
F
S
K
-
F
-
N
-
I
---
H
---
V
A
L
L
I
G
A
T
T
P
S
E
K
E
K
I
K
S
G
L
--
R
N
G
Q
I
D
V
V
I
G
T
H
A
L
I
Q
E
------
D
----------
V
H
F
K
N
L
G
L
V
I
I
D
E
Q
H
R
F
--------------------------------------
E
------
A
L
M
N
K
-----------
G
K
M
V
D
T
L
V
M
S
A
T
P
I
P
R
S
M
A
L
A
F
Y
G
--
D
--
L
--
D
V
--
T
V
I
D
----
E
--
M
----
P
P
---
G
R
K
E
V
Q
T
M
L
-
V
P
M
-
D
R--------
V
----
N
E
V
Y
E
F
V
R
Q
E
--
V
---
M
R
G
G
Q
A
F
I
V
Y
P
L
I
K
-----------------------
S
A
V
E
M
Y
E
Y
L
S
--------------------
K
E
V
F
-----------
K
L
G
L
M
H
G
R
L
S
Q
E
E
K
D
R
V
M
L
E
F
A
E
G
R
Y
D
I
L
V
S
T
T
----
V
I
E
V
G
I
D
V
P
R
-
A
N
V
M
V
I
E
N
P
E
R
-----
F
G
L
A
--
Q
-----------
L
H
Q
L
R
G
R
V
G
R
G
G
Q
----
E
A
Y
C
F
L
V
--
V
G
D
V
G
---
E
E
A
M
E
R
L
R
F
F
T
L
---
N
T
D
G
F
K
I
A
E
Y
D
L
K
T
R
G
P
G
E
----
K
Q
H
G
L
S
G
F
K
V
A
D
L
Y
R
D
L
K
L
L
E
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
62.36
19%
-41
- C1 -
2D7D
2
UVRB_BACSU
A:
[17-643]
--------
Q
P
K
A
I
E
K
L
V
K
G
I
Q
E
G
K
K
H
Q
T
L
L
G
-
A
T
G
T
G
K
T
F
T
V
S
N
L
I
K
E
V
N
-
K
P
T
L
V
I
A
H
N
K
T
L
A
G
Q
L
Y
S
E
F
K
E
F
F
P
N
N
A
V
E
Y
F
V
SYYD
Y
Y
Q
P
EAYV
P
Q
T
D
T
F
-
I
E
K
D
A
S
I
N
D
E
I
D
K
L
-
R
H
S
A
T
S
A
L
F
E
R
-
R
D
V
I
I
I
A
S
V
-
S
C
I
Y
G
L
G
S
P
E
E
Y
R
E
M
V
V
S
L
R
T
E
M
E
I
E
R
N
E
L
L
R
K
L
V
D
I
Q
Y
A
R
N
D
I
D
F
Q
R
G
T
F
R
V
R
G
D
V
V
E
I
F
P
A
S
R
D
E
H
C
V
R
V
E
F
F
G
D
E
I
E
R
I
R
E
V
D
A
L
T
G
E
I
L
G
D
R
D
H
V
A
I
F
P
A
S
H
F
V
T
R
A
E
K
M
E
K
A
I
Q
N
I
E
K
E
L
E
E
Q
L
K
V
M
H
E
N
GK
L
L
E
A
Q
R
L
E
Q
R
T
R
Y
D
L
E
M
M
R
E
M
G
F
C
S
G
I
E
N
Y
S
R
H
L
T
L
R
P
-
P
G
ST
P
Y
T
-
L
L
D
Y
F
P
D
D
F
M
I
V
-
V
-
D
-
E
S
H
V
T
I
P
Q
----------
V
R
G
M
F
N
G
D
Q
A
R
K
Q
V
L
-----
V
D
-
H
G
--
F
RL
P
S
A
L
D
N
R
P
L
R
F
-
E
E
F
E
K
H
M
H
N
--
I
V
Y
V
S
A
T
---
P
G
P
Y
E
I
E
H
T
D
EM
V
E
-
Q
I
I
R
PTGLL
D
P
L
I
D
V
R
P
I
------
E
G
Q
I
D
D
L
I
G
E
I
Q
A
R
-
I
E
R
-
N
E
R
V
L
V
T
T
L
T
K
K
M
S
E
D
L
T
D
Y
L
K
E
I
---
G
I
K
-
V
N
Y
L
HSEIK
T
L
E
R
I
E
I
I
R
D
L
R
L
G
KY
D
V
L
V
G
I
N
L
L
R
E
G
L
D
I
P
E
V
S
L
V
A
I
L
D
A
D
K
E
G
F
L
R
S
E
R
S
L
I
Q
T
I
G
R
--
A
A
R
N
A
E
G
R
V
I
M
Y
A
D
KIT
K
S
M
E
I
A
I
N
E
T
K
R
R
R
E
Q
Q
E
R
F
N
E
E
H
G
I
T
P
------
K
T
I
N
--------------------------------------------
K
K
E
R
Q
K
V
V
E
Q
M
E
H
E
M
K
E
A
A
K
A
L
D
F
E
R
A
A
E
L
R
D
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
58.96
22%
-58
- C1 -
3HJH
1
MFD_ECOLI
A:
[5-450]
-------------
Y
R
Y
T
L
P
V
K
A
-
G
E
Q
R
L
L
G
E
-
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
H
A
-
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
-
D
Q
M
V
M
N
L
-------------
A
D
W
E
T
L
P
Y
D
S
F
S
P
-
H
Q
D
I
I
S
S
-
R
L
S
T
L
Y
Q
L
P
T
M
Q
R
-
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
P
E
------------
H
-----
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
---
Q
P
L
F
F
-
S
E
--
P
L
P
P
L
F
S
Y
F
P
A
N
T
L
L
V
-
N
-
T
G
D
L
E
T
S
A
E
R
----------
F
Q
A
D
T
L
A
R
F
E
N
R
G
V
D
PM
R
P
L
L
P
-
P
Q
--
S
--
L
W
L
R
V
D
E
L
F
S
E
L
K
N
W
-
P
R
V
Q
L
--
K
T
E
H
L
P
T
---
K
A
A
N
A
--
N
L
G
--
F
Q
-
K
L
P
D
-----
L
A
V
Q
A
Q
Q
K
--------
A
P
L
D
A
L
R
K
F
L
E
T
F
-----
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
-
A
P
Q
R
I
M
R
L
-------------
D
E
A
S
D
R
--
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
58.60
21%
-56
- C1 -
2DB3
3
VASA1_DROME
A:
[64-408]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
I
I
I
D
N
V
N
K
S
G
Y
-----
K
-
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
------
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
---
E
DP
H
E
L
E
L
G
R
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
-
S
-
Y
-
L
---
K
---
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
----
C
--
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T-
F
----------
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
-----
M
GF
S
E
D
------------
M
------
R
-----
R
------
I
M
T
H
V
TM---------
R
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
--
L
--
K
--
N
Y
--
V
F
V
A
----
I
G
I
V
----
G
G
---
A
C
S
D
V
K
Q
T
I
-
Y
E
V
-
N
---------
K
----
Y
A
K
R
S
K
L
I
E
I
L
-
S
---
E
Q
A
D
G
T
I
V
F
V
E
T
K
R
-----------------------
G
A
D
F
L
A
S
F
L
S
--------------------
E
K
-
E
----------
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
----
V
A
S
R
G
L
D
I
K
N
-
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
--
D
-----------
Y
V
H
R
I
G
R
T
G
R
V
G
N
----
N
G
R
A
T
S
F
--
F
D
P
E
K
D
R
A
I
A
A
D
L
V
K
I
L
E
G
S
G
Q
T
V
P
D
F
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
58.33
19%
-59
- C1 -
3FHT
4
DD19B_HUMAN
A:
[46-380]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
----
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
E
---
P
ANK-----
Y
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
-
Y
-
P
E
L
---
K
---
L
A
Y
A
V
R
G
N
K
-------
L
E
R
G
--
Q
K
I
S
E
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
SKLK
F
----------
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
-----
T
QGH
Q
D
Q
-----------
S
------
I
-----
R
------
I
Q
R
M
L
-----------
P
R
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
--
V
--
P
--
D
P
--
N
V
I
K
----
L
K
R
E
----
E
E
---
T
L
D
T
I
K
Q
Y
Y
-
V
L
C
-
S
S--------
R
----
D
E
K
F
Q
A
L
C
N
L
--
Y
GA-
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
-----------------------
T
A
S
W
L
A
A
E
L
S
--------------------
K
E
-
G
----------
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
----
V
C
A
R
G
I
D
V
E
Q
-
V
S
V
V
I
N
F
D
L
P
V
DKDGN
P
D
N
E
--
T
-----------
Y
L
H
R
I
G
R
T
G
R
F
G
K
----
R
G
L
A
V
N
M
--
V
D
S
K
H
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
58.05
20%
-48
- C1 -
3HJH
1
MFD_ECOLI
A:
[14-450]
-----------------------
G
E
Q
R
L
L
G
E
-
L
T
G
A
A
C
A
T
L
V
A
E
I
A
E
R
-
H
A
G
P
V
V
L
I
A
P
D
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
-
Q
M
V
M
N
L
-------------
A
D
W
E
T
L
P
Y
D
S
F
S
P
-
H
Q
D
I
I
S
S
-
R
L
S
T
L
Y
Q
L
P
T
M
-
Q
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
K
G
Q
R
L
S
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
D
Q
V
M
E
H
G
E
Y
A
T
R
G
A
L
L
D
L
F
P
M
G
-
S
E
L
P
Y
R
L
D
F
F
D
D
E
I
D
S
L
R
V
F
D
V
D
S
Q
R
T
L
E
E
V
E
A
I
N
L
L
P
A
H
E
F
P
T
D
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
R
D
-----------------
P
E
H
I
Y
Q
Q
V
S
K
G
T
L
P
A
G
I
E
Y
W
---
Q
P
L
F
F
-
S
E
P-
L
P
P
-
L
F
S
Y
F
P
A
N
T
L
L
----
V
-
N
T
G
D
L
E
T
S
----------
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
-----
G
V
D
P
M
--
R
P
-
L
L
P
P
Q
S
L
W
L
R
V
-
D
E
L
F
S
E
L
K
N
W
P
R
V
Q
L
K
T
E
---
H
L
P
---------
T
K
A
A
N
A
N
-----
L
G
F
Q
K
L
P
D
L
AVQAQQ
K
A
P
L
D
A
L
R
K
F
L
E
T
F
-----
D
G
P
V
V
F
S
V
E
S
E
G
R
R
E
A
L
G
E
L
L
A
R
I
---
K
I
A
-
P
Q
R
I
MRL----------
D
E
A
S
D
R
--
G
R
Y
L
M
I
G
A
A
E
H
G
F
V
D
T
V
R
N
L
A
L
I
C
E
S
D
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
56.56
17%
-60
- C1 -
3PEY
10
DBP5_YEAST
A:
[26-356]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
----
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
PED
A
--------
S
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
-
T
-
K
-
I
---
T
---
S
Q
L
I
V
P
D
S
F
--------
E
K
N
--
K
Q
I
N
A
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
R
R
K-
L
----------
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
-----
Q
-----------------
Q
G
L
G
D
Q
C
I
-----
R
------
V
K
R
F
L
-----------
P
K
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
--
V
--
P
--
N
A
--
N
T
L
E
LQ--
T
--
N
----
E
V
---
N
V
D
A
I
K
Q
L
Y
-
M
D
C
-
K
---------
N
E
---
A
D
K
F
D
V
L
T
E
L
Y
G
L
---
M
T
I
G
S
S
I
I
F
V
A
T
K
K
-----------------------
T
A
N
V
L
Y
G
K
L
K
--------------------
S
E
-
G
----------
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
----
V
L
A
R
G
I
D
I
P
T
-
V
S
M
V
V
N
Y
D
L
P
T
LANGQ
A
D
P
A
--
T
-----------
Y
I
H
R
I
G
R
T
G
R
F
G
R
----
K
G
V
A
I
S
F
--
V
H
D
K
N
S
F
N
I
L
S
A
I
Q
K
Y
F
G
D
I
E
M
T
R
V
P
T
D
D
W
D
E
V
E
K
I
V
K
K
V
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
56.19
19%
-64
- C1 -
1OYW
1
RECQ_ECOLI
A:
[10-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
G
A
K
Q
V
L
Q
E
T
F
G
-----
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
------
R
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
L
L
L
--------------
N
G
L
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
N
------
G
-
V
---
A
---
A
A
C
L
N
S
T
Q
T
R
E
Q
Q
L
E
V
M
T
G
C
--
R
T
G
Q
I
R
L
L
Y
I
A
P
E
R
L
M
L
------
D
N
F
L
E
H
-----
L
A
H
W
N
P
V
L
L
A
V
D
E
A
H
C
I
S
Q
WGH--
D
-----------------
F
------
R
-----
P
E
Y
A
A
LG
Q
L
R
Q
R
-----------
F
P
T
L
P
F
M
A
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
R
L
L
G
L
--
N
--
D
P
--
L
I
-
Q
----
I
--
S
----
S
F
---
D
R
P
N
I
R
Y
M
L
-
M
E
K
-
F
---------------
K
P
L
D
Q
L
M
R
Y
--
V
Q
E
-
Q
R
G
K
S
G
I
I
Y
C
N
S
R
A
-----------------------
K
V
E
D
T
A
A
R
L
Q
--------------------
S
K
-
G
----------
I
S
A
A
A
Y
H
A
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
D
D
L
Q
I
V
V
A
T
V
----
A
F
G
M
G
I
N
K
P
N
-
V
R
F
V
V
H
F
D
I
P
R
------
N
I
E
--
S
-----------
Y
Y
Q
E
T
G
R
A
G
R
D
G
L
----
P
A
E
A
M
L
F
--
Y
D
P
A
D
M
A
W
L
R
R
C
L
E
E
K
P
Q
G
Q
L
Q
D
I
E
R
H
K
L
N
A
M
G
A
F
A
E
A
Q
T
C
R
R
L
V
L
L
N
Y
F
G
E
G
R
Q
E
P
C
G
N
C
D
I
C
L
D
P
P
-
K
Q
-
Y
D
G
S
T
-----
D
A
Q
I
A
---
L
S
T
I
G
R
V
N
Q
R
F
G
M
G
Y
V
V
E
V
I
R
G
A
N
N
Q
R
I
R
D
Y
G
H
D
K
L
K
V
Y
G
M
G
R
D
K
S
H
E
H
W
V
S
V
I
R
Q
L
I
H
L
G
L
V
T
Q
N
I
A
Q
H
S
A
L
Q
L
T
E
A
A
R
P
V
L
R
G
E
S
S
L
Q
L
A
V
P
R
I
V
---------------------------------------------------------------
41
HHSearch
55.72
19%
-63
* C1 *
3I5X
3
MS116_YEAST
A:
[84-450]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
K
A
I
T
R
M
E
F
-----
P
-
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
----
E
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
---
N
T
KFDSQY-
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
-
G
-
L
---
K
KY
A
C
V
S
L
V
G
G
T
D
F
---
R
A
A
M
N
K
M
--
N
K
L
R
P
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
YS
N
----------
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
E
-----
I
GF
R
D
D
------------
L
------
E
-----
T
------
I
S
G
I
L
N
E
K
NSKS----
A
D
N
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
--
M
--
N
KK
E
C
--
L
F
L
D
----
T
--
V
DKNE
P
E
---
A
H
E
R
I
D
Q
S
V
V
I
S
E
-
K
F
--------
A
N
S
I
-
F
A
A
V
E
H
I
K
K
Q
--
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
-----------------------
F
T
S
F
L
C
S
I
L
K
--------------------
N
E
-
F
K
K-------
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
----
V
G
A
R
G
M
D
F
P
N
-
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
--
N
-----------
Y
I
H
R
I
G
R
T
A
R
S
G
K
----
E
G
S
S
V
L
F
--
I
C
K
D
E
L
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
Y
E
P
S
E
E
I
K
S
E
V
L
E
A
V
T
E
E
P
E
D
I
S
D
I
V
I
S
L
I
S
S
Y
R
S
C
I
K
E
Y
R
F
S
-
E
R
-
R
I
L
P
E
-----
I
A
S
T
Y
---
G
V
L
L
N
D
P
Q
L
K
I
P
V
S
R
R
F
L
D
K
L
G
L
S
R
S
P
I
G
K
A
M
F
E
I
R
D
---------------------------------------------------------------------------------------------------------------------------
47
HHSearch
55.16
20%
-64
- C1 -
1XTI
4
DX39B_HUMAN
A:
[29-358]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
------
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
E
---
P
VTG-----
Q
V
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
-
M
P
N
-
V
---
K
---
V
A
V
F
F
G
G
L
S
I
K
K
D
E
---
E
V
L
--
K
K
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
N
K-
S
----------
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
-----
Q
L
D
M
R
R
D
-----------
V
------
Q
-----
E
------
I
F
R
M
T
-----------
P
H
E
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
--
M
--
Q
--
D
P
--
M
E
I
F
----
V
--
D
----
D
E
TKL
T
L
H
G
L
Q
Q
Y
Y
-
V
K
L
-
K
---------
D
NE
K
N
R
K
L
F
D
L
L
-
D
V
------
L
E
F
N
Q
V
V
I
F
V
K
S
V
Q
-----------------------
R
C
I
A
L
A
Q
L
L
V
--------------------
E
Q
-
N
----------
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
----
L
F
G
R
G
M
D
I
E
R
-
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
D
--
T
-----------
Y
L
H
R
V
A
R
A
G
R
F
G
T
----
K
G
L
A
I
T
F
--
V
S
D
E
N
D
A
K
I
L
N
D
V
Q
D
R
F
E
V
N
I
S
E
L
P
D
E
I
D
I
S
S
Y
I
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
54.53
19%
-62
- C1 -
3SQW
3
MS116_YEAST
A:
[31-399]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
H
K
A
I
T
R
M
E
F
-----
P
-
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
S
----
E
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
---
N
T
KFDSQY-
M
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
-
N
Y
G
-
L
KKY
A
---
C
V
S
L
V
G
G
T
D
F
---
R
A
A
M
N
K
M
--
N
K
L
R
P
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
YS
N
----------
K
F
F
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
E
-----
I
-----------------
G
F
R
D
D
L
-
E
-----
T
------
I
S
G
I
L
N
E
K
NSKS----
A
D
N
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
--
M
--
N
--
K
K
EC
L
F
L
D
----
T
--
V
DKNE
P
E
---
A
H
E
R
I
D
Q
S
V
V
I
S
E
-
K
F
--------
A
N
S
I
-
F
A
A
V
E
H
I
K
K
Q
--
I
K
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
-----------------------
F
T
S
F
L
C
S
I
L
K
--------------------
N
E
-
F
K
K-------
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
----
V
G
A
R
G
M
D
F
P
N
-
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
--
N
-----------
Y
I
H
R
I
G
R
T
A
R
S
G
K
----
E
G
S
S
V
L
F
--
I
C
K
D
E
L
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
Y
E
P
S
E
E
I
K
S
E
V
L
E
A
V
T
E
E
P
E
D
I
S
D
I
V
I
S
L
I
S
S
Y
R
S
C
I
K
E
Y
R
F
S
-
E
R
-
R
I
L
P
E
-----
I
A
S
T
Y
---
G
V
L
L
N
D
P
Q
L
K
I
P
V
S
R
R
F
L
D
K
L
G
L
S
R
S
P
I
G
K
A
M
F
E
I
R
----------------------------------------------------------------------------------------------------------------------------
51
HHSearch
54.09
18%
-58
- C1 -
1HV8
5
H669_METJA
A:
[17-346]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
N
A
I
R
N
K
G
F
-----
E
-
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
D
-----
E
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
L
V
N
---
E
NN------
G
I
E
A
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
G
N
-
K
-
N
-
L
---
K
---
I
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
-------
A
L
K
N
A
N
I
V
V
G
T
P
G
R
I
L
D
------
H
I
N
R
GT-----
L
N
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
N
-----
M
GF
I
K
D
------------
V
------
E
-----
K
------
I
L
N
A
C
-----------
N
K
D
K
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
--
M
--
G
--
D
Y
--
S
F
I
K
----
A
--
K
----
I
-----
N
A
N
I
E
Q
S
Y
-
V
E
V
-
N
---------
E
----
N
E
R
F
E
A
L
C
R
L
--
L
K--
N
K
E
F
Y
G
L
V
F
C
K
T
K
R
-----------------------
D
T
K
E
L
A
S
M
L
R
--------------------
D
I
-
G
----------
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
----
V
M
S
R
G
I
D
V
N
D
-
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
E
--
S
-----------
Y
M
H
R
I
G
R
T
G
R
A
G
K
----
K
G
K
A
I
S
I
--
I
N
R
R
E
Y
K
K
L
R
Y
I
E
R
A
M
K
L
K
I
K
K
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
53.87
20%
-38
- C1 -
4NL4
3
?
H:
[18-747]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
A
H
V
A
L
-
P
V
P
-
L
P
R
T
-------------
F
D
Y
L
------------
L
P
E
G
M
A
V
K
A
G
C
R
V
R
V
P
F
G
K
Q
E
R
I
G
I
V
A
A
----
V
--
S
--
E
R
S
E
L
P
L
D
E
L
K
P
V
A
------
E
A
L
D
D
--------
E
P
V
F
S
--
T
T
V
W
R
L
L
M
W
A
A
E
Y
Y
H
H
P
I
G
D
V
L
F
H
A
L
P
V
M
L
R
Q
G
K
P
A
S
A
T
P
L
W
Y
W
F
A
T
E
Q
G
Q
V
V
D
L
N
G
L
K
R
S
R
K
Q
Q
Q
A
L
A
A
L
R
Q
G
K
I
W
R
H
Q
V
G
E
L
E
F
N
E
A
A
L
Q
A
L
R
GKG
L
A
E
L
A
C
E
A
T
D
W
R
S
A
Y
S
VAGER
L
-
R
L
N
T
E
Q
A
T
A
V
G
A
I
H
S
--
A
A
D
R
F
S
A
W
L
L
A
G
I
T
G
S
G
K
T
E
V
Y
L
S
V
L
E
N
V
L
A
---
Q
--------
G
R
Q
A
L
V
M
V
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
------
A
---
P
---
V
E
V
L
H
S
G
L
N
D
S
E
R
L
S
A
W
L
K
A
--
K
N
G
E
A
A
I
V
I
G
T
R
S
S
L
F
T
------
P
------------
F
K
D
L
G
V
I
V
I
D
E
E
H
D
S
S
Y
-----
K
-----------------
Q
------
Q
-----
E
------
G
W
R
Y
H
-----------
A
R
D
L
A
V
W
R
A
H
S
E
Q
I
P
I
I
L
G
S
A
T
P
A
--
L
--
E
--
T
L
--
H
N
V
R
QGKY
R
--
Q
----
L
T
---
L
S
K
P
A
Q
Q
H
V
-
L
D
L
-
K
GQPLQAGLS
P
----
A
L
I
S
R
-
M
R
Q
H
--
L
---
Q
A
D
N
Q
V
I
L
F
L
N
R
R
G
FAPALLCHDCGWIAECPRCDSYY
T
L
H
Q
A
Q
H
H
L
R
CHHCDSQRPIPRQCPSCGST
H
L
-
V
P
VGIGTEQL
E
Q
A
L
A
P
L
F
P
E
V
P
I
S
R
I
D
R
H
L
A
A
V
H
R
G
G
A
R
I
L
I
G
T
Q
----
M
L
A
K
G
H
H
F
P
D
-
V
T
L
V
S
L
L
D
V
D
G
-----
A
L
F
S
--
A
DFRSAERFAQL
Y
T
Q
V
S
G
R
A
G
R
A
G
K
----
Q
G
E
V
I
L
Q
TH
H
P
E
H
P
L
L
Q
T
L
L
Y
K
------------
G
Y
D
A
F
A
E
Q
A
L
A
E
R
Q
T
M
Q
L
-----
P
P
W
T
S
H
V
L
I
R
A
E
D
H
N
N
Q
Q
A
P
-
L
F
L
Q
Q
L
R
N
-----
L
L
Q
A
S
---
P
L
A
D
E
K
L
W
V
L
G
P
V
P
A
L
-----
R
W
Q
I
L
L
Q
H
P
-----
S
R
V
R
L
Q
H
I
V
S
G
T
L
A
L
I
N
T
L
P
E
--
A
W
V
L
D
V
D
P
I
E
G
-------------------------------------------------------------------------------------------
42
HHSearch
53.71
19%
-65
- C1 -
2V1X
4
RECQ1_HUMAN
A:
[26-375]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
W
S
G
K
V
K
D
I
L
Q
N
V
F
K
-----
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
------
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
------
S
--------
D
G
F
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
------
G
-
I
---
S
---
A
T
M
L
N
A
S
S
S
K
E
H
V
K
W
V
H
A
E
M
V
N
K
N
S
E
L
K
L
I
Y
V
T
P
E
K
I
A
K
------
S
K
M
F
M
S
R
L
E
K
A
Y
E
A
R
R
F
T
R
I
A
V
D
E
V
H
C
C
S
Q
WGH--
D
-----------------
F
------
R
-----
P
D
Y
K
A
L
G
I
L
K
R
Q
-----------
F
P
N
A
S
L
I
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
--
L
CI
E
--
K
C
--
F
T
F
-----
T
--
A
----
S
F
---
N
R
P
N
L
Y
Y
E
V
-
R
Q
K
-
P
---------
S
N
T
--
E
D
F
I
E
D
I
V
K
L
--
I
N
G
R
Y
K
G
Q
S
G
I
I
Y
C
F
S
Q
K
-----------------------
D
S
E
Q
V
T
V
S
L
Q
--------------------
N
L
-
G
----------
I
H
A
G
A
Y
H
A
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
V
V
V
A
T
V
----
A
F
G
M
G
I
D
K
P
D
-
V
R
F
V
I
H
H
S
M
S
K
------
S
M
E
--
N
-----------
Y
Y
Q
E
S
G
R
A
G
R
D
D
M
----
K
A
D
C
I
L
Y
--
Y
G
F
G
D
I
F
R
I
S
S
M
V
V
M
E
N
V
G
Q
Q
K
L
Y
E
M
V
S
Y
C
Q
N
I
S
K
C
R
R
V
L
M
A
Q
H
F
D
E
V
W
A
C
N
K
M
C
D
N
C
C
K
D
S
A
F
E
R
K
N
-
I
T
-
E
Y
C
R
D
-----
L
I
K
I
L
---
K
Q
A
E
E
L
N
E
K
L
T
P
L
K
L
I
D
S
W
M
G
K
G
A
A
K
L
R
V
A
G
V
V
A
P
T
L
P
R
E
D
L
E
K
I
I
A
H
F
L
I
Q
Q
Y
L
K
E
D
Y
S
F
T
A
Y
A
T
I
S
Y
L
K
I
G
P
K
A
N
L
L
N
N
E
A
H
A
I
T
M
Q
V
T
K
--------------------------------------------------------------------
48
HHSearch
52.51
17%
-56
- C1 -
1S2M
-
DHH1_YEAST
A:
[61-391]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
A
G
F
-----
E
-
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
------
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
K
PKL
N
--------
K
I
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
-
C
-
G
-
I
---
S
---
C
M
V
T
T
G
G
T
N
L
R
D
D
I
---
L
R
---
L
N
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
------
L
A
S
R
KV-----
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
S
-----
R
-----------------
D
------
F
K
T
I
I
E
Q
------
I
L
S
F
L
-----------
P
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
--
L
--
H
--
K
P
--
Y
E
I
N
----
L
--
M
----
E
E
L--
T
L
K
G
I
T
Q
Y
Y
-
A
F
V
-
E
---------
E
----
R
Q
K
L
H
C
L
N
T
L
F
S
K
---
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
-----------------------
R
V
E
L
L
A
K
K
I
T
--------------------
D
L
-
G
----------
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
----
L
L
T
R
G
I
D
I
Q
A
-
V
N
V
V
I
N
F
D
F
P
K
------
T
A
E
--
T
-----------
Y
L
H
R
I
G
R
S
G
R
F
G
H
----
L
G
L
A
I
N
L
--
I
N
W
N
D
R
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
A
A
I
P
A
T
I
D
K
S
L
Y
V
A
E
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
52.38
17%
-41
- C1 -
3EIQ
-
IF4A1_HUMAN
A:
[40-380]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
S
L
L
R
G
I
Y
A
Y
G
F
-----
E
-
K
P
S
A
I
Q
Q
R
A
I
L
P
C
I
K
G
------
Y
D
V
I
A
Q
A
Q
S
G
T
G
K
T
A
T
F
A
I
S
I
L
Q
Q
I
E
LDL
K
--------
A
T
Q
A
L
V
L
A
P
T
R
E
L
A
Q
Q
I
Q
K
V
V
M
A
L
G
D
Y
-
M
-
G
-
A
---
S
---
C
H
A
C
I
G
G
T
N
V
R
A
---
E
V
Q
K
L
--
Q
M
E
A
P
H
I
I
V
G
T
P
G
R
V
F
D
M
L
N
R
R-
Y
----------
L
S
P
K
Y
I
K
M
F
V
L
D
E
A
D
E
M
L
S
R
GF
K
D
Q
-----------------
I
------
Y
-----
D
------
I
F
Q
K
L
-----------
N
S
N
T
Q
V
V
L
L
S
A
T
M
P
S
D
V
L
E
V
T
K
K
F
--
M
--
R
--
D
P
--
I
R
I
L
----
V
--
K
----
K
E
E
L
-
T
L
E
G
I
R
Q
F
Y
-
I
N
V
E
R
---------
E
----
E
W
K
L
D
T
L
C
D
L
--
Y
E
T
-
L
T
I
T
Q
A
V
I
F
I
N
T
R
R
-----------------------
K
V
D
W
L
T
E
K
M
H
--------------------
A
R
-
D
----------
F
T
V
S
A
M
---
M
D
Q
K
E
R
D
V
I
M
R
E
F
R
S
G
---
V
L
I
T
T
D
----
L
L
A
--
I
D
V
Q
Q
-
V
S
L
V
I
N
Y
D
L
P
T
------
N
R
E
--
N
-----------
Y
I
H
R
I
G
R
G
-----------
V
A
I
N
M
--
V
T
E
E
D
K
R
T
L
R
D
I
E
T
F
Y
N
T
S
I
E
E
M
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
52.06
15%
-71
- C1 -
3OIY
2
?
A:
[10-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
S
F
F
K
K
K
F
G
-----
K
-
D
L
T
G
Y
Q
R
L
W
A
K
R
I
V
Q
G
------
K
S
F
T
M
V
A
P
T
G
V
G
K
T
T
F
G
M
M
T
A
L
W
L
A
R
---
K
--------
G
K
K
S
A
L
V
F
P
T
V
T
L
V
K
Q
T
L
E
R
L
Q
K
L
A
D
E
---
K
-
V
---
K
---
I
F
G
F
Y
S
S
M
K
K
E
E
K
E
K
F
E
K
S
F
--
E
E
D
D
Y
H
I
L
V
F
S
T
Q
F
V
S
K
N
R
E
---
K
----------
L
S
Q
K
R
F
D
F
V
F
V
D
D
V
D
A
V
L
K
-----
A
S
R
N
I
D
T
L
L
M
M
V
GIP
E
E
I
I
------
R
-----
K
------
A
F
S
T
I
K
Q
G
K
I
Y
E
R
PKN
L
K
P
G
I
L
V
V
S
S
A
T
A
K
P
R
G
I
R
P
L
L
F
R
--
D
--
L
L-
N
F
--
T
V
G
R
----
L
-------
V
S
---
V
A
R
N
I
T
H
V
R
-
I
S
S
-
R
---------
S
----
K
E
K
L
V
E
L
L
E
I
--
F
-----
R
D
G
I
L
I
F
A
Q
T
E
E
-----------------------
E
G
K
E
L
Y
E
Y
L
K
--------------------
R
F
-
K
---------------
F
N
V
G
E
T
W
S
E
F
E
K
N
F
E
D
F
K
V
G
K
I
N
I
L
I
G
V
Q
A
YYG
K
L
T
R
G
V
D
L
P
E
R
I
K
Y
V
I
F
W
G
T
P
S
------
G
P
D
V
Y
T
-----------
Y
I
Q
A
S
G
R
S
S
R
I
L
N
GVL
V
K
G
V
S
V
I
F
--
E
E
D
E
E
I
F
E
S
L
K
T
R
L
L
L
I
A
E
E
E
I
I
E
E
A
E
A
N
W
K
E
L
V
H
E
V
E
E
S
R
R
R
S
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------