@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0018: (2015-11-27 )
MTLEKRFNKYLDRIEVSLIRQFDQSISDIPGMVKLTLGEPDFTTPDHVKEAAKSAIDANQSYYTGMSGLLALRQAAADFAKDKYNLTYNPDCEILVTIGATEALSASLIAILEAGDVVLLPAPAYPGYEPIVNLVGADIVEIDTRENDFRLTPEMLETAIIQQGEKLKAVLLNYPTNPTGITYSRQEIASLAEVLKKYDIFVISDEVYSELTYTGQQHVSIAEYLPNQTILINGLSKSHAMTGWRVGLVYAPEAFIAQIIKSHQYMVTAASTISQFAGVEALSVGKNDTLPMRQGYIKRRDYIIDKMSKLGFKIIKPSGAFYIFAKIPDSYPQDSFKFCQDFAYQQAVAIIPGVAFGKYGEGYIRLSYAASMEVIETAMARLKVFMESYEG
Atome Classification :
(31 SA)
.........10.....---...20....----....30........40--.........50.......-.-60........70........80........-90........100.......110.......120.......130...-...--.140..-.-.----------..-.150.......160.......170.......180.......190.......200.......210....--...220--..---..---.-..230.......240.......250.........---260.......270.......280.---.-------.---..--..290........-.300.......310........320.......330---------.......340.......350.......-----360---........370.......380.......390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
L
E
K
R
F
N
K
Y
L
D
R
I
E
V
---
S
L
I
R
Q
F
D
Q
S
----
I
SDIP
G
M
V
K
L
T
LGEP---DFT
T
P
D
H
V
K
E
A
A
K
S
AIDA-N-Q
S
Y
Y
T
G
M
S
G
L
L
A
L
R
Q
A
A
A
D
F
AKDKYNLTYN-PDC
E
I
L
V
T
IGA
T
E
A
L
S
A
S
L
I
A
ILEAG
D
V
V
L
L
PAPAYP
G
Y
E
P
I
V
N
L
V-GA
D
--
I
V
E
I
DT-R-E----------ND-FRL
T
P
E
M
L
E
T
A
I
I
QQGE
K
L
K
A
V
L
L
NYPTNPTG
I
T
Y
S
R
Q
E
I
A
S
L
A
E
V
L
K
KY
D
I
F
V
I
S
D
E
V
Y
S
E
LTYTGQ--QHV
S
I
A
--
E
Y---LP---N-
Q
T
I
L
I
NGLSKSHAM
T
G
W
R
V
G
L
V
Y--A
P
E
A
F
I
A
Q
I
---
I
KSH
Q
Y
M
V
T
A
A
S
T
I
S
Q
F
AG
V
E
A
L
S---V-------G---KN--DT
L
--
P
M
R
Q
G
Y
I
K
-
R
R
D
Y
I
I
D
K
M
S
KL-G
F
K
I
IKPSG
A
F
Y
I
F
A
KIPDSYP---------
Q
D
S
F
K
F
C
Q
D
F
A
Y
Q
Q
A
V
A
IIPGVAFGKY-----G
E
----
G
Y
I
R
L
SYA
A
S
M
E
V
I
E
T
A
M
A
R
L
K
V
F
M
E
SYEG
52
HHSearch
95.63
38%
-112
- C1 -
1GD9
2
?
A:
[2-387]
-----
A
L
S
D
R
L
E
L
V
S
A
---
S
E
I
R
K
L
F
D
I
----
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
---
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
-
G
L
T
-
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
-
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
-
Y
E
E
----------
D
E
-
F
R
L
N
V
D
E
L
K
K
Y
V
T
-
D
--
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
--
R
H
Y
S
I
A
--
S
L
DG-
M
F
---
E
-
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
--
A
P
S
W
I
I
E
R
M
---
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
-------
E
R
S
-
W
K
--
A
V
E
--
E
M
R
K
E
Y
D
R
-
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
---------
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
-----
G
E
----
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
L
2
PsiBlast_PDB
91.57
38%
-110
- C1 -
1GDE
4
?
A:
[5-380]
-----------
D
R
L
E
L
VSA
S
E
I
R
K
L
F
D
I
----
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
---
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
-
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
-
Y
-
E
----------
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
--
R
H
Y
S
I
A
SL
D
G
---
M
F
---
E
-
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
--
A
P
S
W
I
I
E
R
M
---
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
-------
E
---
R
S
W
K
A
V
E
--
E
M
R
K
E
Y
D
R
-
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
---------
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
-----
G
E
----
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
L
3
PsiBlast_PDB
91.46
38%
-110
- C1 -
1GD9
2
?
A:
[5-380]
-----------
D
R
L
E
L
VSA
S
E
I
R
K
L
F
D
I
----
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
---
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
-
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
-
Y
-
E
----------
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
--
R
H
Y
S
I
A
SL
D
G
---
M
F
---
E
-
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
--
A
P
S
W
I
I
E
R
M
---
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
-------
E
---
R
S
W
K
A
V
E
--
E
M
R
K
E
Y
D
R
-
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
---------
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
-----
G
E
----
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
L
1
PsiBlast_PDB
91.14
38%
-112
- C1 -
1DJU
2
?
A:
[4-379]
-----------
D
R
L
E
L
VSA-----------------
K
D
V
I
S
L
G
I
G
E
P
---
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
-
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
-
Y
-
E
----------
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
--
R
H
Y
S
I
A
--
S
L
DG-
M
F
---
E
-
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
--
A
P
S
W
I
I
E
R
M
---
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
-------
E
---
R
S
W
K
A
V
E
--
E
M
R
K
E
Y
D
R
-
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
---------
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
-----
G
E
----
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
E
R
V
L
K
E
R
K
L
23
PsiBlast_CBE
91.08
38%
-112
- C1 -
1GD9
2
?
B:
[5-380]
-----------
D
R
L
E
L
VSA
S
E
I
R
K
L
F
D
I
----
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
---
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
-
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
-
Y
-
E
----------
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
--
R
H
Y
S
I
A
SL
D
G
---
M
F
---
E
-
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
--
A
P
S
W
I
I
E
R
M
---
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
-------
E
---
R
S
WK
A
V
E
--
E
M
R
K
E
Y
D
R
-
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
---------
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
-----
G
E
----
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
L
21
PsiBlast_CBE
91.00
38%
-112
- C1 -
1DJU
2
?
B:
[4-379]
-----------
D
R
L
E
L
VS-------------------
D
V
I
S
L
G
I
G
E
P
---
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
-
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
-
Y
-
E
----------
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
--
R
H
Y
S
I
A
--
S
L
DG-
M
F
---
E
-
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
--
A
P
S
W
I
I
E
R
M
---
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
-------
E
---
R
S
W
K
A
V
E
--
E
M
R
K
E
Y
D
R
-
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
---------
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
-----
G
E
----
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
E
R
V
L
K
E
R
K
L
22
PsiBlast_CBE
90.43
38%
-108
- C1 -
1GDE
4
?
B:
[5-380]
-----------
D
R
L
E
L
VSA
S
E
I
R
K
L
F
D
I
----
A
A
G
M
K
D
V
I
S
L
G
I
G
E
P
---
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
K
-
G
-
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
-
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
-
Y
-
E
----------
E
D
E
F
R
L
N
V
D
E
L
K
K
Y
V
T
---
D
K
T
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
A
--
R
H
Y
S
I
A
SL
D
G
---
M
F
---
E
-
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
--
A
P
S
W
I
I
E
R
M
---
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
K
---
D
-------
E
---
R
S
WK
A
V
E
--
E
M
R
K
E
Y
D
R
-
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
-
G
---------
L
T
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
G
K
A
-----
G
E
----
G
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
K
L
58
HHSearch
85.09
36%
-115
* C1 *
1O4S
8
AAT_THEMA
A:
[39-388]
----------------------------------
K
G
E
D
V
I
N
L
T
A
G
E
P
---
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
-
G
E
V
-
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
-
P
D
-
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
-
G
G
T
--
V
N
V
V
E
T
-
F
M
S
----------
K
N
-
F
Q
P
S
L
E
E
V
E
G
L
L
V
-
G
--
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
E
---
F
T
S
I
L
--
D
V
SE-
G
F
---
D
-
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
--
S
S
E
K
V
A
T
A
V
---
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
---
V
-------
D
---
N
-----
S
--
Y
M
V
Q
T
F
K
E
-
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
R
G
-------------
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
-------
P
----
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
---
38
PsiBlast_CBE
84.36
34%
-109
- C1 -
5BJ3
2
AAT_THET8
D:
[33-378]
--------------------------------------
L
V
A
L
T
A
G
E
P
---
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
-
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
-
E
----------
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
---
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
H
F
S
P
G
--
R
V
---
A
P
---
E
-
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--
G
P
K
E
V
I
K
A
M
---
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
-------
S
---
R
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
-
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
----------
D
E
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
-----------
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
40
PsiBlast_CBE
84.27
34%
-109
- C1 -
5BJ3
2
AAT_THET8
B:
[33-378]
--------------------------------------
L
V
A
L
T
A
G
E
P
---
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
-
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
-
E
----------
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
---
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
H
F
S
P
G
--
R
V
---
A
P
---
E
-
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--
G
P
K
E
V
I
K
A
M
---
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
-------
S
---
R
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
-
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
----------
D
E
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
-----------
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
10
PsiBlast_PDB
83.94
34%
-109
- C1 -
5BJ3
2
AAT_THET8
A:
[33-378]
--------------------------------------
L
V
A
L
T
A
G
E
P
---
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
-
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
-
E
----------
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
---
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
H
F
S
P
G
--
R
V
---
A
P
---
E
-
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--
G
P
K
E
V
I
K
A
M
---
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
-------
S
---
R
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
-
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
----------
D
E
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
-----------
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
9
PsiBlast_PDB
83.78
34%
-108
- C1 -
5BJ4
3
AAT_THET8
A:
[33-378]
--------------------------------------
L
V
A
L
T
A
G
E
P
---
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
-
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
-
E
----------
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
---
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
H
F
S
P
G
--
R
V
---
A
P
---
E
-
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--
G
P
K
E
V
I
K
A
M
---
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
-------
S
---
R
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
-
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
----------
D
E
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
-----------
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
53
HHSearch
83.76
32%
-103
- C1 -
1J32
2
?
A:
[2-387]
-----
K
L
A
A
R
V
E
S
V
S
P
---
S
M
T
L
I
I
D
A
K
A
K
A
M
K
A
E
G
I
D
V
C
S
F
S
A
G
E
P
---
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
-
G
K
T
-
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
-
A
D
-
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
-
E
G
T
--
P
V
I
L
P
T
-
T
V
E
----------
T
Q
-
F
K
V
S
P
E
Q
I
R
Q
A
I
T
-
P
--
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
--
Q
H
L
S
I
G
--
A
A
S
P
E
A
Y
---
E
-
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
--
G
P
V
P
L
V
K
A
A
---
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
E
---
N
-------
S
---
Q
D
--
C
V
Q
--
E
M
L
A
A
F
A
E
-
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
A
K
T
-
G
---------
R
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
A
-------
D
----
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
G
I
L
-
4
PsiBlast_PDB
83.72
34%
-118
- C1 -
1O4S
8
AAT_THEMA
A:
[43-388]
--------------------------------------
V
I
N
L
T
A
G
E
P
---
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
-
G
-
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
-
P
D
-
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
-
G
G
T
--
V
N
V
V
E
T
F
M
-
S
----------
K
N
-
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
---
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
E
FT
S
I
L
D
V
S
--
E
G
---
F
----
D
-
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
--
S
S
E
K
V
A
T
A
V
---
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
---
V
---------------
D
N
S
--
Y
M
V
Q
T
F
K
E
-
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
R
G
-------------
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
-------
P
----
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
---
24
PsiBlast_CBE
83.18
34%
-117
- C1 -
1O4S
4
AAT_THEMA
B:
[43-388]
--------------------------------------
V
I
N
L
T
A
G
E
P
---
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
K
-
G
-
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
-
P
D
-
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
-
G
G
T
--
V
N
V
V
E
T
F
M
-
S
----------
K
N
-
F
Q
P
S
L
E
E
V
E
G
L
L
V
G
---
K
T
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
T
D
E
FT
S
I
L
D
V
S
--
E
G
---
F
----
D
-
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
--
S
S
E
K
V
A
T
A
V
---
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
E
---
V
---------------
D
N
S
--
Y
M
V
Q
T
F
K
E
-
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
V
R
G
-------------
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
-------
P
----
G
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
---
39
PsiBlast_CBE
82.77
34%
-108
- C1 -
5BJ3
2
AAT_THET8
C:
[33-378]
--------------------------------------
L
V
A
L
T
A
G
E
P
---
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
-
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
-
E
----------
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
---
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
H
F
S
P
G
--
R
V
---
A
P
---
E
-
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--
G
P
K
E
V
I
K
A
M
---
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
-------
S
---
R
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
-
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
----------
D
E
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
-----------
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
55
HHSearch
82.35
33%
-103
- C1 -
1B5P
3
AAT_THET8
A:
[2-382]
----
R
G
L
S
R
R
V
Q
A
M
K
P
---
S
A
T
V
A
V
N
A
K
A
L
E
L
R
R
Q
G
V
D
L
V
A
L
T
A
G
E
P
---
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
-
G
K
T
-
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
-
L
P
E
----------
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
-
P
--
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
E
--
H
F
S
P
G
---
R
V
---
A
P
---
E
-
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--
G
P
K
E
V
I
K
A
M
---
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
---
N
-------
Q
E
A
S
R
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
-
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
-
A
---------
P
D
E
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
-------
F
----
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
27
PsiBlast_CBE
82.24
34%
-107
- C1 -
5BJ4
3
AAT_THET8
B:
[33-378]
--------------------------------------
L
V
A
L
T
A
G
E
P
---
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
-
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
-
E
----------
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
---
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
H
F
S
P
G
--
R
V
---
A
P
---
E
-
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--
G
P
K
E
V
I
K
A
M
---
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
-------
S
---
R
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
-
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
----------
D
E
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
-----------
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
48
PsiBlast_CBE
81.10
33%
-109
- C1 -
1XI9
2
?
B:
[40-402]
--------------------------------------
V
I
R
L
N
I
G
D
P
VKF
D
F
Q
P
P
E
H
M
K
E
A
Y
C
K
A
I
K
E
-
G
-
H
N
Y
Y
G
D
S
E
G
L
P
E
L
R
K
A
I
V
E
R
E
K
R
K
N
G
V
D
I
T
-
P
D
-
D
V
R
V
T
A
A
V
T
E
A
L
Q
L
I
F
G
A
L
L
D
P
G
D
E
I
L
V
P
G
P
S
Y
P
P
Y
T
G
L
V
K
F
Y
-
G
G
K
--
P
V
E
Y
R
T
I
E
-
E
----------
E
D
-
W
Q
P
D
I
D
D
I
R
K
K
I
T
---
D
R
T
K
A
I
A
V
I
N
P
N
N
P
T
G
A
L
Y
D
K
K
T
L
E
E
I
L
N
I
A
G
E
Y
E
I
P
V
I
S
D
E
I
Y
D
L
M
T
Y
E
G
E
---
H
I
S
P
G
--
S
L
---
T
K
---
D
V
P
V
I
V
M
N
G
L
S
K
V
Y
F
A
T
G
W
R
L
G
Y
M
Y
F
V
D
P
E
N
K
L
S
E
V
R
E
A
I
D
R
L
A
R
I
R
L
C
P
N
T
P
A
Q
F
A
A
I
A
G
L
T
-----------
G
---
P
M
--
D
Y
L
--
K
E
Y
M
K
K
L
K
E
R
R
D
Y
I
Y
K
R
L
N
E
I
P
G
I
S
T
T
K
P
Q
G
A
F
Y
I
F
P
K
I
E
V
G
P
W
---------
K
N
D
K
E
F
V
L
D
V
L
H
N
A
H
V
L
F
V
H
G
S
G
F
G
E
Y
-----
G
A
----
G
H
F
R
A
V
F
L
P
P
I
E
I
L
E
E
A
M
D
R
F
E
K
F
M
K
E
R
--
56
HHSearch
80.81
31%
-108
- C1 -
3E2Y
6
KAT3_MOUSE
A:
[20-409]
---------------------------------
A
A
D
P
S
V
V
N
L
G
Q
G
F
P
---
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
A
F
I
D
N
M
N
-
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
E
-
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
-
G
A
V
--
P
V
F
I
P
L
-
R
-
S
K
PTDGMKWTS
S
D
-
W
T
F
D
P
R
E
L
E
S
K
F
S
-
S
--
K
T
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
T
G
H
--
T
H
V
K
I
A
--
T
L
PG-
M
W
---
E
-
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
--
G
P
A
H
L
I
K
H
L
---
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
W
---
I
D
I
K
R
M
DD
P
---
E
C
--
Y
F
N
--
S
L
P
K
E
L
E
V
-
K
R
D
R
M
V
R
L
L
N
S
V
-
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
L
G
A
DLSDMNSDE
P
Y
D
Y
K
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
C
D
S
KSKPH
F
E
----
K
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
I
F
R
A
W
N
-----
11
PsiBlast_PDB
80.70
34%
-109
- C1 -
1B5O
3
AAT_THET8
A:
[33-378]
--------------------------------------
L
V
A
L
T
A
G
E
P
---
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
-
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
-
E
----------
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
---
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
H
F
S
P
G
--
R
V
---
A
P
---
E
-
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--
G
P
K
E
V
I
K
A
M
---
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
N
Q
E
A
-------
S
---
R
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
-
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
----------
D
E
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
-----------
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
41
PsiBlast_CBE
79.91
34%
-107
- C1 -
1B5O
3
AAT_THET8
B:
[33-378]
--------------------------------------
L
V
A
L
T
A
G
E
P
---
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
-
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
-
E
----------
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
---
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
H
F
S
P
G
--
R
V
---
A
P
---
E
-
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--
G
P
K
E
V
I
K
A
M
---
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
-------
S
---
R
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
-
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
----------
D
E
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
-----------
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
25
PsiBlast_CBE
79.60
34%
-108
- C1 -
1GCK
4
AAT_THET8
B:
[33-378]
--------------------------------------
L
V
A
L
T
A
G
E
P
---
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
-
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
-
E
----------
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
---
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
H
F
S
P
G
--
R
V
---
A
P
---
E
-
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--
G
P
K
E
V
I
K
A
M
---
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
-------
S
---
R
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
-
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
----------
D
E
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
-----------
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
26
PsiBlast_CBE
79.50
34%
-107
- C1 -
1B5P
3
AAT_THET8
B:
[33-378]
--------------------------------------
L
V
A
L
T
A
G
E
P
---
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
Q
-
G
-
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
-
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
-
E
----------
E
G
-
F
V
P
D
P
E
R
V
R
R
A
I
T
P
---
R
T
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
E
G
---
E
H
F
S
P
G
--
R
V
---
A
P
---
E
-
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
--
G
P
K
E
V
I
K
A
M
---
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
T
NQE
A
-------
S
---
R
A
--
F
V
E
--
M
A
R
E
A
Y
R
R
-
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
S
P
I
A
P
----------
D
E
V
R
A
A
E
R
L
-
L
E
A
G
V
A
V
V
P
G
T
D
F
A
A
F
-----------
G
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
-----
13
PsiBlast_PDB
77.97
33%
-102
- C1 -
1J32
2
?
A:
[32-385]
--------------------------------------
V
C
S
F
S
A
G
E
P
---
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
-
G
-
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
-
A
D
-
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
--
V
I
L
P
T
T
-
V
-
E
----------
T
Q
-
F
K
V
S
P
E
Q
I
R
Q
A
I
T
---
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
--
Q
H
L
S
I
G
--
A
A
---
S
P
E
A
Y
E
-
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
--
G
P
V
P
L
V
K
A
A
---
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
E
---
N
-------
S
---
Q
D
--
C
V
Q
--
E
M
L
A
A
F
A
E
-
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
A
K
T
G
----------
R
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
-------
A
D
----
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
G
I
L
-
19
PsiBlast_PDB
77.85
31%
-117
- C1 -
1V2D
1
?
A:
[26-364]
-------------------------------------
G
A
V
N
L
G
Q
G
F
P
---
S
N
P
P
P
P
F
L
L
E
A
V
R
R
A
L
-
G
-
R
-
Q
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
------
E
F
A
V
E
-
P
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
-
G
A
K
A
R
L
V
R
L
D
L
-
T
-
P
----------
E
G
-
F
R
L
D
L
S
A
L
E
K
A
L
T
P
---
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
-
Y
Y
G
E
--
R
P
R
R
L
R
--
E
F
---
A
P
---
E
-
R
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
--
G
P
K
E
F
M
P
R
L
---
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
A
E
A
L
K
---
L
-------
A
---
R
R
--
E
G
F
Y
E
A
L
R
E
G
Y
R
R
-
R
R
D
L
L
A
G
G
L
R
A
M
-
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L
P
G
------------
W
D
A
F
R
L
V
E
----
E
A
R
V
A
L
I
P
A
S
A
F
--
Y
-----
L
E
DPPK
D
L
F
R
F
A
F
C
K
T
E
E
E
L
H
L
A
L
E
R
L
G
R
V
V
-----
50
PsiBlast_CBE
77.09
31%
-118
- C1 -
1V2F
4
?
A:
[26-364]
-------------------------------------
G
A
V
N
L
G
Q
G
F
P
---
S
N
P
P
P
P
F
L
L
E
A
V
R
R
A
L
-
G
-
R
-
Q
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
------
E
F
A
V
E
-
P
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
-
G
A
K
A
R
L
V
R
L
D
L
-
T
-
P
----------
E
G
-
F
R
L
D
L
S
A
L
E
K
A
L
T
P
---
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
-
Y
Y
G
E
--
R
P
R
R
L
R
--
E
F
---
A
P
---
E
-
R
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
--
G
P
K
E
F
M
P
R
L
---
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
A
E
A
L
K
---
L
-------
A
---
R
R
--
E
G
F
Y
E
A
L
R
E
G
Y
R
R
-
R
R
D
L
L
A
G
G
L
R
A
M
-
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L
P
G
------------
W
D
A
F
R
L
V
E
----
E
A
R
V
A
L
I
P
A
S
A
F
--
Y
-----
L
E
DPPK
D
L
F
R
F
A
F
C
K
T
E
E
E
L
H
L
A
L
E
R
L
G
R
V
V
-----
49
PsiBlast_CBE
76.82
31%
-118
- C1 -
1V2F
4
?
B:
[26-364]
-------------------------------------
G
A
V
N
L
G
Q
G
F
P
---
S
N
P
P
P
P
F
L
L
E
A
V
R
R
A
L
-
G
-
R
-
Q
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
------
E
F
A
V
E
-
P
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
-
G
A
K
AR
L
V
R
L
D
L
-
T
-
P
----------
E
G
-
F
R
L
D
L
S
A
L
E
K
A
L
T
P
---
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
-
Y
Y
G
E
--
R
P
R
R
L
R
--
E
F
---
A
P
---
E
-
R
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
--
G
P
K
E
F
M
P
R
L
---
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
A
E
A
L
K
---
L
-------
A
---
R
R
--
E
G
F
YE
A
L
R
E
G
Y
R
R
-
R
R
D
L
L
A
G
G
L
R
A
M
-
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L
P
G
------------
W
D
A
F
R
L
V
E
----
E
A
R
V
A
L
I
P
A
S
A
F
--
Y
-----
L
E
DPPK
D
L
F
R
F
A
F
C
K
T
E
E
E
L
H
L
A
L
E
R
L
G
R
V
------
45
PsiBlast_CBE
76.51
33%
-102
- C1 -
1J32
2
?
B:
[32-385]
--------------------------------------
V
C
S
F
S
A
G
E
P
---
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
Q
-
G
-
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
-
A
D
-
N
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
--
V
I
L
P
T
T
-
V
-
E
----------
T
Q
-
F
K
V
S
P
E
Q
I
R
Q
A
I
T
---
P
K
T
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
D
D
A
--
Q
H
L
S
I
G
--
A
A
---
S
P
EAY
E
-
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
--
G
P
V
P
L
V
K
A
A
---
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
E
---
N
-------
S
---
Q
D
--
C
V
Q
--
E
M
L
A
A
F
A
E
-
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
A
K
T
G
----------
R
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
G
-------
A
D
----
D
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
H
G
I
L
-
20
PsiBlast_PDB
76.26
31%
-117
- C1 -
1V2E
4
?
A:
[26-364]
-------------------------------------
G
A
V
N
L
G
Q
G
F
P
---
S
N
P
P
P
P
F
L
L
E
A
V
R
R
A
L
-
G
-
R
-
Q
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
------
E
F
A
V
E
-
P
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
-
G
A
K
AR
L
V
R
L
D
L
-
T
-
P
----------
E
G
-
F
R
L
D
L
S
A
L
E
K
A
L
T
P
---
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
-
Y
Y
G
E
--
R
P
R
R
L
R
--
E
F
---
A
P
---
E
-
R
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
--
G
P
K
E
F
M
P
R
L
---
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
A
E
A
L
K
---
L
-------
A
---
R
R
--
E
G
F
Y
E
A
L
R
E
G
Y
R
R
-
R
R
D
L
L
A
G
G
L
R
A
M
-
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L
P
G
------------
W
D
A
F
R
L
V
E
----
E
A
R
V
A
L
I
P
A
S
A
F
--
Y
-----
L
E
DPPK
D
L
F
R
F
A
F
C
K
T
E
E
E
L
H
L
A
L
E
R
L
G
R
V
V
-----
51
PsiBlast_CBE
75.79
31%
-120
- C1 -
1V2E
4
?
B:
[26-364]
-------------------------------------
G
A
V
N
L
G
Q
G
F
P
---
S
N
P
P
P
P
F
L
L
E
A
V
R
R
A
L
-
G
-
R
-
Q
D
Q
Y
A
P
P
A
G
L
P
A
L
R
E
A
L
A
E
------
E
F
A
V
E
-
P
E
S
-
V
V
V
T
S
G
A
T
E
A
L
Y
V
L
L
Q
S
L
V
G
P
G
D
E
V
V
V
L
E
P
F
F
D
V
Y
L
P
D
A
F
L
A
-
G
A
K
AR
L
V
R
L
D
L
-
T
-
P
----------
E
G
-
F
R
L
D
L
S
A
L
E
K
A
L
T
P
---
R
T
R
A
L
L
L
N
T
P
M
N
P
T
G
L
V
F
G
E
R
E
L
E
A
I
A
R
L
A
R
A
H
D
L
F
L
I
S
D
E
V
Y
D
E
L
-
Y
Y
G
E
--
R
P
R
R
L
R
--
E
F
---
A
P
---
E
-
R
T
F
T
V
G
S
A
G
K
R
L
E
A
T
G
Y
R
V
G
W
I
V
--
G
P
K
E
F
M
P
R
L
---
A
G
M
R
Q
W
T
S
F
S
A
P
T
P
L
Q
A
G
V
A
E
A
L
K
---
L
-------
A
---
R
R
--
E
G
F
YE
A
L
R
E
G
Y
R
R
-
R
R
D
L
L
A
G
G
L
R
A
M
-
G
L
R
V
Y
V
P
E
G
T
Y
F
L
M
A
E
L
P
G
------------
W
D
A
F
R
L
V
E
----
E
A
R
V
A
L
I
P
A
S
A
F
--
Y
-----
L
E
DPPK
D
L
F
R
F
A
F
C
K
T
E
E
E
L
H
L
A
L
E
R
L
G
R
V
------