@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0025: (2015-11-27 )
MTYEVKSLNEECGVFGIWGHPQAAQVTYFGLHSLQHRGQEGAGIVSNDNGKLYGYRNVGLLSEVFKNQSELDNLTGNAAIGHVRYATAGSADIRNIQPFLYKFHDGQFALCHNGNLTNAISLRKELEKQGAIFNASSDTEILMHLIRRSHNPSFMGKVKEALSTVKGGFAYLLMTEDKLIAALDPNAFRPLSIGQMQNGAWVISSETCAFEVVGAKWVRDVEPGEVILIDDSGIQCDRYTDETQLAICSMEYVYFARPDSTIHGVNVHTARKNMGKRLAQEFKQDADIVIGVPNSSLSAAMGFAEESGLPNEMGLVKNQYTQRTFIQPTQELREQGVRMKLSAVSGVVKGKRVVMIDDSIVRGTTSRRIVGLLREAGASEVHVAIASPELKYPCFYGIDIQTRRELISANHAADEVCDIIGADSLTYLSLDGLIESIGLETKAPNGGLCVAYFDGHYPTPLYDYEEEYLRSLEEKTSFYIQKVK
Atome Classification :
(20 SA)
.........10........20........30........40...-..-...-50........-.60........70........80........90........100...-....110.......120....-...-130.......140....--...-----150-------.........160..----.....170...-.---...180.......190....----..----.200.......210.....-------..220.....--------..230......-.---240....-...250.......260.......270.......280.-----.-----.....290.......300.......310.......320......--.330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
Y
E
VKSLNEEC
G
V
F
G
IWGHPQA
A
Q
V
T
Y
F
G
L
H
S
L
Q
HRGQEGA
G
I
-
V
S-NDN-
G
-
K
L
Y
G
Y
R
N
V
-
G
L
L
S
E
V
F
K
N
Q
S
E
L
D
NLTGNAAIG
H
V
R
Y
ATAGSADIRNIQ
P
F
L
Y
K
FHD-G
Q
F
A
L
C
HNGNL
T
N
A
I
S
L
R
K
E
L
-
E
KQ-G
A
I
FNASS
D
T
E
I
L
M
H
L
I
--RRS-----H---------N
P
S
F
M
G
K
V
K
E
A
L
S
T
----VKG
G
F
A
Y
L
L
M
T-E---D
K
L
I
A
ALDPNAFRPLSIGQM----QN----
G
A
W
V
ISSE
T
C
A
F
E
V
VG
A
K
W
-------
V
RDVEPG
E
V
I
--------
L
IDDSGIQCDR-Y---TDE
T
Q
L
A
-
I
C
S
M
E
Y
V
Y
F
ARPD
S
T
I
H
G
V
N
V
H
T
A
R
K
N
M
G
K
R
L
A
Q
E
F
K-----Q-----DA
D
I
V
I
GVPNS
S
L
S
A
A
MG
F
A
E
ESGLP
N
E
M
G
L
V
KNQYTQRTFIQ
P
--
T
Q
E
L
R
EQGV
R
M
K
L
S
A
VSGVVKG
K
R
V
V
M
IDDSIVRGT
T
S
R
R
I
V
G
L
L
R
EAGA
S
E
V
H
V
A
IASPELKY
P
C
F
YGI
D
I
Q
T
R
R
E
L
I
SANH
A
A
D
E
V
C
D
I
IGAD
S
L
T
Y
L
S
L
D
G
L
I
E
S
IGLETKAPNG
G
L
C
V
A
Y
FDGHYPTPL
Y
D
Y
E
E
E
Y
L
R
S
L
E
E
K
T
S
F
Y
I
Q
KVK
60
Fugue
99.20
58%
-105
- C6 -
1AO0
5
PUR1_BACSU
A:
[1-459]
-----------
C
G
V
F
G
I
W
G
H
E
E
A
P
Q
I
T
Y
Y
G
L
H
S
L
Q
H
R
G
Q
E
G
A
G
I
-
V
A
T
D
G
--
E
-
K
L
T
A
H
K
G
Q
-
G
L
I
T
E
V
F
Q
N
G
E
L
-
S
K
V
K
G
K
G
A
I
G
H
V
R
Y
A
T
G
----
Y
E
N
V
Q
P
L
L
F
R
S
Q
N
N
G
S
L
A
L
A
H
N
G
N
L
V
N
A
T
Q
L
K
Q
Q
L
-
E
N
Q
-
G
S
I
F
Q
T
S
S
D
T
E
V
L
A
H
L
I
--
K
R
S
-----
G
HF---------
T
L
K
D
Q
I
K
N
S
L
S
M
----
L
K
G
A
Y
A
F
L
I
M
T
-
E
T---
E
M
I
V
A
L
D
P
N
G
L
R
P
L
S
I
G
M
M
----
G
-----
D
A
Y
V
V
A
S
E
T
C
A
F
D
V
V
G
A
T
Y
-------
L
R
E
V
E
P
G
E
M
L
--------
I
I
N
D
E
-
G
M
K
S
E
-
R
FSM--
N
I
N
R
S
-
I
C
S
M
E
Y
I
Y
F
S
R
P
D
S
N
I
D
G
I
N
V
H
S
A
R
K
N
L
G
K
M
L
A
Q
E
S
A
------
V
----
E
A
D
V
V
T
G
V
P
D
S
S
I
S
A
A
I
G
Y
A
E
A
T
G
I
P
Y
E
L
G
L
I
K
N
R
Y
V
G
R
T
F
I
--QP
S
Q
A
L
R
E
Q
G
V
R
M
K
L
S
A
V
R
G
V
V
E
G
K
R
V
V
M
V
D
D
S
I
V
R
G
T
T
S
R
R
I
V
T
M
L
R
E
A
G
A
T
E
V
H
V
K
I
S
S
P
P
I
A
H
P
C
F
Y
G
I
D
T
S
T
H
E
E
L
I
A
S
S
H
S
V
E
E
I
R
Q
E
I
G
A
D
T
L
S
F
L
S
V
E
G
L
L
K
G
I
G
R
K
Y
D
D
S
N
C
G
Q
C
L
A
C
F
T
G
K
Y
P
T
E
-
I
Y
Q
D
T
V
-
L
P
H
V
K
-----------
27
PsiBlast_CBE
88.39
38%
-95
- C6 -
1ECB
4
PUR1_ECOLI
B:
[1-478]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
L
D
N
FR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
T
N
R
L
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
D
IDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
EWEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
----------
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
------------
1
PsiBlast_PDB
88.12
38%
-97
- C6 -
1ECF
3
PUR1_ECOLI
A:
[1-479]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
L
D
NFR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
T
N
R
L
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
D
IDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
EWEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
P
--
G
Q
Q
L
R
R
K
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
D
T
L
R
N
D
D
A
K
A
V
Q
5
PsiBlast_PDB
87.82
38%
-93
- C6 -
1ECJ
1
PUR1_ECOLI
A:
[1-479]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
L
D
NFR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
T
N
R
L
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
D
IDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
EWEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
P
--
G
Q
Q
L
R
R
K
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
D
T
L
R
N
D
D
A
K
A
V
Q
2
PsiBlast_PDB
87.67
38%
-96
- C6 -
1ECG
4
PUR1_ECOLI
A:
[1-479]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
L
D
NFR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
T
N
R
L
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
D
IDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
EWEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
P
--
G
Q
Q
L
R
R
K
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
D
T
L
R
N
D
D
A
K
A
V
Q
21
PsiBlast_CBE
87.50
38%
-93
- C6 -
1ECJ
1
PUR1_ECOLI
C:
[1-479]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
LDNFR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
TNRL
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
DIDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
EWEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
P
--
G
Q
Q
L
R
R
K
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
D
T
L
R
N
D
D
A
K
A
V
Q
23
PsiBlast_CBE
86.98
38%
-93
- C6 -
1ECF
3
PUR1_ECOLI
B:
[1-479]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
LDNFR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
TNRL
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
DIDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
EWEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
P
--
G
Q
Q
L
R
R
K
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
D
T
L
R
N
D
D
A
K
A
V
Q
4
PsiBlast_PDB
86.96
38%
-88
- C6 -
1ECC
5
PUR1_ECOLI
A:
[1-479]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
L
D
NFR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
T
N
R
L
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
D
IDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
E
WEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
P
--
G
Q
Q
L
R
R
K
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
D
T
L
R
N
D
D
A
K
A
V
Q
25
PsiBlast_CBE
86.86
38%
-98
- C6 -
1ECB
4
PUR1_ECOLI
D:
[1-479]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
LDNFR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
TNRL
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
DIDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
EWEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
----------
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
D
T
L
---------
24
PsiBlast_CBE
86.86
38%
-91
- C6 -
1ECC
6
PUR1_ECOLI
B:
[1-479]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
LDNFR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
TNRL
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
DIDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
EWEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
P
--
G
Q
Q
L
R
R
K
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
D
T
L
R
N
D
D
A
K
A
V
Q
22
PsiBlast_CBE
86.56
38%
-92
- C6 -
1ECG
4
PUR1_ECOLI
B:
[1-479]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
LDNFR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
TNRL
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
DIDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
EWEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
P
--
G
Q
Q
L
R
R
K
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
D
T
L
R
N
D
D
A
K
A
V
Q
3
PsiBlast_PDB
85.95
38%
-92
- C6 -
1ECB
4
PUR1_ECOLI
A:
[1-479]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
L
D
N
FR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
T
N
R
L
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
D
IDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
EWEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
P
--------
K
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
D
T
L
---------
38
HHSearch
85.88
39%
-93
* C6 *
1ECF
3
PUR1_ECOLI
A:
[1-489]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
N
C
F
R
L
R
K
A
N
-
G
L
V
S
D
V
F
E
A
-
R
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
--
Y
G
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
-
F
E
E
K
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
-----
L
D
NFRHYPLE
A
D
N
I
F
A
A
I
A
A
T
N
R
L
----
I
R
G
A
Y
A
C
V
A
M
I
-
I
G--
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
----
D
I
DEN
R
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
Q
C
---
A
D
N
P
V
S
N
-
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
R
EWED
L
-----
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
P
--
G
Q
Q
L
R
R
K
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
-
E
N
P
D
I
Q
Q
F
E
C
S
V
F
N
G
V
Y
V
T
K
D
V
D
Q
G
Y
L
D
F
--
L
D
T
L
R
N
D
D
A
K
A
V
Q
26
PsiBlast_CBE
84.49
38%
-94
- C6 -
1ECB
4
PUR1_ECOLI
C:
[1-479]
-----------
C
G
I
V
G
I
A
G
V
M
P
V
N
Q
S
I
Y
D
A
L
T
V
L
Q
H
R
G
Q
D
A
A
G
I
-
I
T
-
I
D
A
-
N
-
N
C
F
R
L
R
K
A
N
G
L
V
S
D
V
F
E
A
R
-
H
M
Q
R
L
Q
G
N
M
G
I
G
H
V
R
Y
P
T
A
G
S
S
S
A
S
E
A
Q
P
F
Y
V
N
S
P
Y
-
G
-
I
T
L
A
H
N
G
N
L
T
N
A
H
E
L
R
K
K
L
F
E
E
K
-
R
R
H
I
N
T
T
S
D
S
E
I
L
L
N
I
F
--
A
S
E
L
D
NFR
H
---------
Y
P
L
E
A
D
N
I
F
A
A
I
A
A
T
N
R
L
I
R
G
A
Y
A
C
V
A
M
I
I
G
---
H
G
M
V
A
F
R
D
P
N
G
I
R
P
L
V
L
G
K
R
D
IDE
N
R
----
T
E
Y
M
V
A
S
E
S
V
A
L
D
T
L
G
F
D
F
-------
L
R
D
V
A
P
G
E
A
I
--------
Y
I
T
E
E
G
Q
L
F
T
R
-
Q
---
C
A
D
N
P
V
S
N
P
C
L
F
E
Y
V
Y
F
A
R
P
D
S
F
I
D
K
I
S
V
Y
S
A
R
V
N
M
G
T
K
L
G
E
K
I
A
-----
R
EWEDL
D
I
D
V
V
I
P
I
P
E
T
S
C
D
I
A
L
E
I
A
R
I
L
G
K
P
Y
R
Q
G
F
V
K
N
R
Y
V
G
R
T
F
I
M
P
--
G
Q
Q
L
R
R
K
S
V
R
R
K
L
N
A
N
R
A
E
F
R
D
K
N
V
L
L
V
D
D
S
I
V
R
G
T
T
S
E
Q
I
I
E
M
A
R
E
A
G
A
K
K
V
Y
L
A
S
A
A
P
E
I
R
F
P
N
V
Y
G
I
D
M
P
S
A
T
E
L
I
A
H
G
R
E
V
D
E
I
R
Q
I
I
G
A
D
G
L
I
F
Q
D
L
N
D
L
I
D
A
V
R
A
E
N
P
D
I
Q
Q
F
E
C
-
S
V
F
N
G
V
Y
V
T
K
--
D
V
D
Q
G
Y
L
D
F
L
D
T
L
R
--------
40
HHSearch
57.11
28%
-100
- C6 -
1XFF
3
GLMS_ECOLI
A:
[1-222]
-----------
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
-
A
V
-
V
D
A
E
G
-
H
M
T
R
L
R
R
L
-
G
K
V
Q
M
L
A
Q
A
-
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
-----
E
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
-
K
A
R
-
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
--
N
W
E
L
K
---
Q
---------
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
----
L
R
G
A
Y
G
T
V
I
M
D
-
S
RHP
D
T
L
L
A
A
R
S
G
---
S
P
L
V
I
G
L
G
----
M
-----
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
-
T
R
R
-------
F
I
F
L
E
E
G
D
I
A
--------
E
I
T
R
R
S
V
N
I
F
D
-
K
---
T
G
A
E
V
K
R
-
Q
D
I
E
S
N
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
56.11
26%
-108
- C6 -
2J6H
1
GLMS_ECOLI
A:
[1-238]
-----------
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
-
D
A
E
-
G
-
H
M
T
R
L
R
R
L
-
G
K
V
-
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
-----
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
-
K
A
R
-
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
-----
Q
---------
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
----
L
R
G
A
Y
G
T
V
I
M
D
-
S
RHP
D
T
L
L
A
A
---
R
S
G
S
P
L
V
I
G
-
L
----
G
M
----
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
-------
I
F
-
L
E
E
G
D
I
A
E
I
T
RR
S
V
N
I
F
D
K
T
G
A
E
V
K
R
-
Q
---
D
I
E
S
N
L
Q
-
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
V
-----
D
-----
L
S
E
L
G
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
--
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
11
PsiBlast_PDB
55.97
25%
-107
- C6 -
3OOJ
1
GLMS_ECOLI
A:
[1-238]
-----------
A
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
-
D
A
E
-
G
-
H
M
T
R
L
R
R
L
-
G
K
V
-
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
-----
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
-
K
A
R
-
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
-----
Q
---------
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
----
L
R
G
A
Y
G
T
V
I
M
D
-
S
RHP
D
T
L
L
A
A
---
R
S
G
S
P
L
V
I
G
-
L
----
G
M
----
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
-------
I
F
-
L
E
E
G
D
I
A
E
I
T
RR
S
V
N
I
F
D
K
T
G
A
E
V
K
R
-
Q
---
D
I
E
S
N
L
Q
-
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
V
-----
D
-----
L
S
E
L
G
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
--
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
R
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
6
PsiBlast_PDB
54.92
26%
-110
- C6 -
4AMV
-
GLMS_ECOLI
A:
[2-239]
-----------
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
-
D
A
E
-
G
-
H
M
T
R
L
R
R
L
-
G
K
V
-
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
-----
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
-
K
A
R
-
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
-----
Q
---------
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
----
L
R
G
A
Y
G
T
V
I
M
D
-
S
RHP
D
T
L
L
A
A
---
R
S
G
S
P
L
V
I
G
-
L
----
G
M
----
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
-------
I
F
-
L
E
E
G
D
I
A
E
I
T
RR
S
V
N
I
F
D
K
T
G
A
E
V
K
R
-
Q
---
D
I
E
S
N
L
Q
-
Y
D
A
G
D
K
G
I
Y
R
H
Y
M
Q
K
E
I
Y
E
Q
P
N
A
I
K
N
T
L
T
G
R
I
S
H
G
Q
V
-----
D
-----
L
S
E
L
G
P
N
A
D
E
L
L
S
K
V
E
H
I
Q
I
L
A
C
G
T
S
Y
N
S
G
M
V
S
R
Y
W
F
E
S
L
A
G
I
P
--
C
D
V
E
I
A
S
E
F
R
Y
R
K
S
A
V
R
R
N
S
L
M
I
T
L
S
Q
S
G
E
T
A
D
T
L
A
G
L
R
L
S
K
E
L
G
Y
L
G
S
L
A
I
C
N
V
P
G
S
S
L
V
R
E
S
D
L
A
L
M
T
N
A
G
T
E
I
G
V
A
S
T
K
A
F
T
T
Q
L
T
V
L
L
M
L
V
A
K
L
S
K
L
K
G
L
D
A
S
I
E
H
D
I
V
H
G
L
Q
A
L
P
S
R
I
E
Q
M
L
S
Q
D
K
R
I
E
A
L
A
E
D
F
S
D
K
H
H
A
L
F
L
G
R
G
D
Q
Y
P
9
PsiBlast_PDB
54.90
25%
-90
- C6 -
1XFF
3
GLMS_ECOLI
A:
[1-238]
-----------
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
-
D
A
E
-
G
-
H
M
T
R
L
R
R
L
-
G
K
V
-
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
-----
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
-
K
A
R
-
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
-----
Q
---------
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
----
L
R
G
A
Y
G
T
V
I
M
D
-
S
RHP
D
T
L
L
A
A
---
R
S
G
S
P
L
V
I
G
-
L
----
G
M
----
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
EG
D
I
A
E
I
T
R
R
S
V
N
--------
I
F
D
K
T
G
A
E
V
K
R
-
Q
---
D
I
E
S
N
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
54.83
25%
-89
- C6 -
1XFG
3
GLMS_ECOLI
A:
[1-238]
-----------
C
G
I
V
G
A
I
A
Q
R
D
V
A
E
I
L
L
E
G
L
R
R
L
E
Y
R
G
Y
D
S
A
G
L
A
V
V
-
D
A
E
-
G
-
H
M
T
R
L
R
R
L
-
G
K
V
-
Q
M
L
A
Q
A
A
E
E
H
P
L
H
G
G
T
G
I
A
H
T
R
W
A
T
H
G
E
P
S
E
V
N
A
H
P
H
V
S
E
-----
H
I
V
V
V
H
N
G
I
I
E
N
H
E
P
L
R
E
E
L
-
K
A
R
-
G
Y
T
F
V
S
E
T
D
T
E
V
I
A
H
L
V
N
W
E
L
K
-----
Q
---------
G
G
T
L
R
E
A
V
L
R
A
I
P
Q
----
L
R
G
A
Y
G
T
V
I
M
D
-
S
RHP
D
T
L
L
A
A
---
R
S
G
S
P
L
V
I
G
-
L
----
G
M
----
G
E
N
F
I
A
S
D
Q
L
A
L
L
P
V
T
R
R
F
I
F
L
E
EG
D
I
A
E
I
T
R
R
S
V
N
--------
I
F
D
K
T
G
A
E
V
K
R
-
Q
---
D
I
E
S
N
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------