@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0029: (2015-11-27 )
MTKRALISVSDKSGIIDFAKELKNLGWDIISTGGTKVALDDAGVETIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDADSHLQAAKDNNIELIDLVVVNLYPFKETILRPDVTYDLAVENIDIGGPSMLRSAAKNHASVTVVVDSADYATVLGELADASQTTFKTRQRLAAKAFRHTAAYDALIAEYFTAQVGEAKPEKLTITYDLKQAMRYGENPQQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDSPTVVALKHMNPCGIGQADDIETAWDYAYEADPVSIFGGIVVLNREVDAATAEKMHPIFLEIIIAPSYSEEALAILTNKKKNLRILELPFDAQAASEVEAEYTGVVGGLLVQNQDVVAENPSDWQVVTDRQPTEQEATALEFAWKAIKYVKSNGIIITNDHMTLGLGAGQTNRVGSVKIAIEQAKDHLDGAVLASDAFFPFADNIEEIAAAGIKAIIQPGGSVRDQESIDAANKHGLTMIFTGVRHFRH
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.....--..--160.........170.......180.......----190....-----.-..200....-...210.......220....--....230.-......240.......250.......260....---.---..270.......----280-----------....--------------------.-.----------------..-------.290.......300.......310.......320.......330.......340.......350--.......360.......370.-.....--.380.---....-..390......-..400...--....410.......420.......430.......440.......450-----------------------------------------------------------------.---......460.......470.......480.......490.......500.......510...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MT
K
R
A
L
I
SVSDKS
G
I
I
D
F
A
K
E
L
K
N
LG
W
D
I
ISTGG
T
K
V
A
LDDAG
V
E
T
I
A
IDDVTG
F
P
E
MMDG
R
V
K
T
LHPNIHG
G
L
L
ARRD
A
D
S
H
L
Q
AAKDN
N
I
E
L
I
D
L
V
V
V
NLY
P
F
K
E
T
ILRPD
V
T
Y
D
L
A
V
E
N
IDIG
G
P
S
M
L
R
S
A
AKNH
A
S
V
T
V
V
VDSA
D
Y
A
T
V
L
G
E
L--AD--A--S
Q
T
T
F
K
T
R
Q
R
L
A
A
K
A
F
R
H
T
A
A
Y
D
A
L
I
A
E
Y
----
F
T
A
Q
VGE-----A-KP
E
K
L
T
I
T
Y
-
D
L
K
Q
A
M
RYGENPQ
Q
D
-
A
D
F
Y
--
Q
K
ALPTDY-SIASAKQLNGKELSFNNIR
D
A
D
A
A
I
R
I
I
R
DFKD---S---P
T
V
V
A
L
KHMNPC----G-------------IGQA--------------------D-D----------------I
E
-------
T
A
W
DYAYEA
D
P
V
S
I
F
G
G
I
V
V
L
NREVDA
A
T
A
EKM
H
P
I
F
L
E
I
I
IAPSYSE
E
A
L
A
I
L
TNKKKN
L
R
I
L
--ELPFDA
Q
A
A
S
E
V
E
A
E
Y
TG
V
V
G
-
G
L
L
VQ--NQDVV---AENP-SD
W
-
Q
V
VTDRQ-P
T
E
Q
E
A
T
A
--
L
E
F
A
W
K
A
I
K
Y
V
KSN
G
I
I
I
TND
H
M
T
L
G
LGAGQTNRV
G
S
V
K
I
A
I
E
Q
A
K
D
-----------------------------------------------------------------H---LD
G
A
V
LASDAFFPFAD
N
I
E
E
I
A
A
A
G
I
K
A
I
IQPGGSVR
D
Q
E
SIDAANKHGL
T
M
I
F
T
G
V
R
H
FRH
2
PsiBlast_PDB
95.05
43%
-88
- C12 -
4A1O
6
PUR9_MYCTU
A:
[11-523]
--
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
---
D
G
R
V
K
T
L
H
P
R
V
H
A
G
L
L
A
D
L
R
K
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
---
R
--
A
--
G
G
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
----
M
Q
Q
T
L
A
P
EHPVA
A
-
F
P
Q
W
F
G
R
S
W
-
R
R
V
A
M
L
R
Y
G
E
N
P
H
Q
Q
-
A
A
L
Y
--
G
D
--
P
T
A
W
P
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
Q
---
T
----
C
V
A
I
I
K
H
A
N
P
C
----
G
-------------
I
A
I
S
--------------------
S
V
S
----------------
V
A
-------
D
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
-
R
K
K
N
I
R
V
L
--
V
A
A
E
P
L
A
G
G
S
E
L
R
P
----
I
S
G
-
G
L
L
I
Q
--
Q
S
D
Q
L
DAH
G
D
N
P
-
A
N
W
-
T
L
A
T
G
S
P
-
A
D
P
A
T
L
T
D
--
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
A
A
R
L
A
V
E
R
G
G
E
-----------------------------------------------------------------
R
---
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
1
PsiBlast_PDB
94.91
43%
-86
- C12 -
3ZZM
4
PUR9_MYCTU
A:
[11-523]
--
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
E
V
L
D
G
R
V
K
T
L
H
P
R
V
H
A
G
L
L
A
D
L
R
K
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
---
R
--
A
--
G
G
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
----
M
Q
Q
T
L
A
P
EHPVA
A
-
F
P
Q
W
F
G
R
S
W
-
R
R
V
A
M
L
R
Y
G
E
N
P
H
Q
Q
-
A
A
L
Y
--
G
D
--
P
T
A
W
P
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
Q
---
T
----
C
V
A
I
I
K
H
A
N
P
C
----
G
-------------
I
A
I
S
--------------------
S
V
S
----------------
V
A
-------
D
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
-
R
K
K
N
I
R
V
L
--
V
A
A
E
P
L
A
G
G
S
E
L
R
P
----
I
S
G
-
G
L
L
I
Q
--
Q
S
D
Q
L
DAH
G
D
N
P
-
A
N
W
-
T
L
A
T
G
S
P
-
A
D
P
A
T
L
T
D
--
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
A
A
R
L
A
V
E
R
G
G
E
-----------------------------------------------------------------
R
---
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
22
PsiBlast_CBE
93.78
43%
-87
- C12 -
3ZZM
4
PUR9_MYCTU
B:
[11-523]
--
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
E
V
L
D
G
R
V
K
T
L
H
P
R
V
H
A
G
L
L
A
D
L
R
K
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
---
R
--
A
--
G
G
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
----
M
Q
Q
T
L
A
P
EHPVA
A
-
F
P
Q
W
F
G
R
S
W
-
R
R
V
A
M
L
R
Y
G
E
N
P
H
Q
Q
-
A
A
L
Y
--
G
D
--
P
T
A
W
P
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
Q
---
T
----
C
V
A
I
I
K
H
A
N
P
C
----
G
-------------
I
A
I
S
--------------------
S
V
S
----------------
V
A
-------
D
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
-
R
K
K
N
I
R
V
L
--
V
A
A
E
P
L
A
G
G
S
E
L
R
P
----
I
S
G
-
G
L
L
I
Q
--
Q
S
D
Q
L
DAH
G
D
N
P
-
A
N
W
-
T
L
A
T
G
S
P
-
A
D
P
A
T
L
T
D
--
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
A
A
R
L
A
V
E
R
G
G
E
-----------------------------------------------------------------
R
---
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
21
PsiBlast_CBE
93.60
43%
-87
- C12 -
4A1O
6
PUR9_MYCTU
B:
[11-523]
--
R
R
A
L
I
S
V
Y
D
K
T
G
L
V
D
L
A
Q
G
L
S
A
A
G
V
E
I
I
S
T
G
S
T
A
K
T
I
A
D
T
G
I
P
V
T
P
V
E
Q
L
T
G
F
P
E
V
L
D
G
R
V
K
T
L
H
P
R
V
H
A
G
L
L
A
D
L
R
K
S
E
H
A
A
A
L
E
Q
L
G
I
E
A
F
E
L
V
V
V
N
L
Y
P
F
S
Q
T
V
-
E
S
G
A
S
V
D
D
C
V
E
Q
I
D
I
G
G
P
A
M
V
R
A
A
A
K
N
H
P
S
A
A
V
V
T
D
P
L
G
Y
H
G
V
L
A
A
L
---
R
--
A
--
G
G
F
T
L
A
E
R
K
R
L
A
S
L
A
F
Q
H
I
A
E
Y
D
I
A
V
A
S
W
----
M
Q
Q
T
L
A
P
E
H
PVA
A
-
F
P
Q
W
F
G
R
S
W
-
R
R
V
A
M
L
R
Y
G
E
N
P
H
Q
Q
-
A
A
L
Y
--
G
D
--
P
T
A
W
P
G
L
A
Q
A
E
Q
L
H
G
K
D
M
S
Y
N
N
F
T
D
A
D
A
A
W
R
A
A
F
D
H
E
Q
---
T
----
C
V
A
I
I
K
H
A
N
P
C
----
G
-------------
I
A
I
S
--------------------
S
V
S
----------------
V
A
-------
D
A
H
R
K
A
H
E
C
D
P
L
S
A
Y
G
G
V
I
A
A
N
T
E
V
S
V
E
M
A
E
Y
V
S
T
I
F
T
E
V
I
V
A
P
G
Y
A
P
G
A
L
D
V
L
A
-
R
K
K
N
I
R
V
L
--
V
A
A
E
P
L
A
G
G
S
E
L
R
P
----
I
S
G
-
G
L
L
I
Q
--
Q
S
D
Q
L
DAH
G
D
N
P
-
A
N
W
-
T
L
A
T
G
S
P
-
A
D
P
A
T
L
T
D
--
L
V
F
A
W
R
A
C
R
A
V
K
S
N
A
I
V
I
A
A
D
G
A
T
V
G
V
G
M
G
Q
V
N
R
V
D
A
A
R
L
A
V
E
R
G
G
E
-----------------------------------------------------------------
R
---
V
R
G
A
V
A
A
S
D
A
F
F
P
F
P
D
G
L
E
T
L
A
A
A
G
V
T
A
V
V
H
P
G
G
S
V
R
D
E
E
V
T
E
A
A
A
K
A
G
V
T
L
Y
L
T
G
A
R
H
F
A
H
49
HHSearch
91.15
39%
-81
- C12 -
1G8M
2
PUR9_CHICK
A:
[5-593]
-
Q
Q
L
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
-
I
P
E
D
N
A
D
M
N
K
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
--
A
A
SK
D
--
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
----
F
R
K
E
Y
S
---------------
K
G
-
V
S
Q
L
P
L
R
Y
G
M
N
P
H
Q
S
-
P
A
Q
L
--
Y
T
T
R
P
-----
K
L
P
L
T
V
V
N
G
S
-
P
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
A
LG
I
---
P
A
A
A
S
F
K
H
V
S
P
A
----
G
-------------
A
A
V
G
IPLS
E
E
E
A
Q
V
C
MVHDLHKTL
T
-
P
----------------
L
A
-------
S
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
-
S
K
K
K
N
G
G
Y
C
--
V
L
Q
M
D
P
N
Y
-
E
P
D
D
N
E
I
R
T
L
Y
G
-
L
Q
L
M
Q
--
K
R
N
N
A
---
V
I
D
R
-
S
L
F
K
N
I
V
T
K
N
K
T
L
P
E
S
A
V
R
D
--
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
S
W
W
L
R
H
H
P
R
V
L
S
MKFKAGVK
R
A
E
V
S
N
A
I
D
Q
Y
V
T
GTIGE
D
E
D
L
V
K
W
Q
A
M
F
EEVPAQLT
E
A
E
K
K
Q
W
I
A
K
---
L
T
A
V
S
L
S
S
D
A
F
F
P
F
R
D
N
V
D
R
A
K
R
I
G
V
Q
F
I
V
A
P
S
G
S
A
A
D
E
V
V
I
E
A
C
N
E
L
G
I
T
L
I
H
T
N
L
R
L
F
H
H
3
PsiBlast_PDB
90.10
41%
-92
- C12 -
4EHI
7
PUR9_CAMJE
A:
[26-534]
---
R
A
L
L
S
V
S
D
K
E
G
I
V
E
F
G
K
E
L
E
N
L
G
F
E
I
L
S
T
G
G
T
F
K
L
L
K
E
N
G
I
K
V
I
E
V
S
D
F
T
--------------------------------------
I
L
G
I
D
L
V
C
V
N
L
Y
P
F
K
K
T
T
I
M
S
D
-
D
F
D
E
I
I
E
N
I
D
I
G
G
P
A
M
I
R
S
A
A
K
N
Y
K
D
V
M
V
L
C
D
P
L
D
Y
E
K
V
I
-
E
T
--
L
K
--
K
--
G
Q
N
D
E
N
F
R
L
N
L
M
I
K
A
Y
E
H
T
A
N
Y
D
A
Y
I
A
N
Y
M
N
E
R
F
N
G
G
F
G
A
-----
S
-
K
F
I
V
G
Q
K
V
F
-
D
T
K
----
Y
G
E
N
P
H
Q
K
-
G
A
L
Y
--
E
--
F
D
A
F
F
-
S
-
A
N
F
K
A
L
K
G
-
E
A
S
F
N
N
L
T
D
I
N
A
A
L
N
L
A
S
S
F
D
K
---
A
---
P
A
I
A
I
V
K
H
G
N
P
C
----
G
-------------
F
A
I
K
--------------------
E
-
N
----------------
L
V
-------
Q
S
Y
I
H
A
L
K
C
D
S
V
S
A
Y
G
G
V
V
A
I
N
G
T
L
D
E
A
L
A
N
K
I
N
E
I
Y
V
E
V
I
I
A
A
N
V
D
E
K
A
L
A
V
F
E
G
K
K
R
-
I
K
I
F
T
Q
E
S
P
F
L
I
R
S
F
D
K
Y
--
D
F
K
H
I
D
G
-
G
F
V
Y
Q
--
N
S
D
E
V
---
G
E
D
E
L
K
N
A
-
K
L
M
S
Q
R
E
-
A
S
K
E
E
L
K
D
--
L
E
I
A
M
K
I
A
A
F
T
K
S
N
N
V
V
Y
V
K
N
G
A
M
V
A
I
G
M
G
M
T
S
R
I
D
A
A
K
A
A
I
A
K
A
K
E
-----------------------------------------------------------------
M
GLD
L
Q
G
C
V
L
A
S
E
A
F
F
P
F
R
D
S
I
D
E
A
S
K
V
G
V
K
A
I
V
E
P
G
G
S
I
R
D
D
E
V
V
K
A
A
D
E
Y
G
M
A
L
Y
F
T
G
V
R
H
F
L
H
26
PsiBlast_CBE
82.42
37%
-79
- C12 -
1PKX
1
PUR9_HUMAN
D:
[7-462]
----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
I
P
E
D
N
A
D
M
A
R
-
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
QS
S
E
--
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
----
F
R
K
Q
Y
S
K
-----
G
-
V
S
Q
----------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
TL
Q
P
K
L
P
I
T
V
--------
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
---
A
LGI
P
A
A
A
S
F
K
H
V
S
P
A
GAAV
G
-------------
I
P
L
S
--------------------
E
-
D
EAKVCMVYDLYKTLTP
I
S
-------
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
-
K
K
K
N
G
N
Y
C
--
V
L
Q
M
D
-
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
-
L
H
L
S
Q
KR
N
N
G
V
V
---
D
K
S
L
-
F
S
N
-
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
--
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
-----------------------------------------------------------------
W
---
W
L
R
H
H
P
Q
V
L
S
M
K
F
K
T
G
V
K
R
A
E
I
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
D
E
D
L
I
K
W
K
A
L
F
E
E
V
P
E
L
L
T
E
A
E
K
K
E
W
28
PsiBlast_CBE
82.36
37%
-79
- C12 -
1PKX
1
PUR9_HUMAN
B:
[7-462]
----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
I
P
E
D
N
A
D
M
A
R
-
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
Q
S
S
E
--
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
----
F
R
K
Q
Y
S
K
-----
G
-
V
S
Q
----------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
T
L
Q
P
K
L
P
I
T
V
--------
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
---
A
LG
I
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
G
-------------
I
P
L
S
--------------------
E
-
D
E
A
K
V
C
MVYDLYKTLT
P
I
S
-------
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
-
K
K
K
N
G
N
Y
C
--
V
L
Q
M
D
-
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
-
L
H
L
S
Q
K
R
N
N
G
V
V
---
D
K
S
L
-
F
S
N
-
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
--
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
-----------------------------------------------------------------
W
---
W
L
R
H
H
P
Q
V
L
S
M
K
F
K
T
G
V
K
R
A
E
I
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
D
E
D
L
I
K
W
K
A
L
F
E
E
V
P
E
L
L
T
E
A
E
K
K
E
W
30
PsiBlast_CBE
82.30
35%
-85
- C12 -
1ZCZ
3
PUR9_THEMA
B:
[14-464]
--
K
R
I
L
V
S
L
Y
E
K
E
K
Y
L
D
I
L
R
E
L
H
E
K
G
W
E
I
W
A
S
S
G
T
A
K
F
L
K
S
N
G
I
E
A
N
D
V
S
T
I
T
G
F
E
N
L
L
G
G
L
V
K
T
L
H
P
E
I
F
A
G
I
L
G
P
E
P
R
--------------
W
D
V
V
F
V
D
L
Y
P
------
P
P
D
---------
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
W
K
K
V
K
P
A
F
D
M
E
T
L
K
L
A
I
-
E
I
--
D
D
--
E
-------
E
T
R
K
Y
L
A
G
M
T
F
A
F
T
S
V
Y
D
S
I
R
A
N
Q
----
F
V
E
G
I
S
L
-----
A
F
K
R
E
D
L
Q
---------
L
R
Y
G
E
N
P
H
E
K
-
A
F
V
Y
--
G
K
---
P
A
F
-
E
I
L
H
----
E
G
K
T
I
S
F
N
N
I
L
D
A
E
N
A
W
F
M
A
K
N
L
P
R
---
M
---
G
A
V
V
-
V
K
H
Q
S
P
C
----
G
-------------
A
A
I
G
--------------------
E
-
D
----------------
K
V
-------
E
I
V
K
K
A
I
E
A
D
D
E
S
S
F
G
G
I
L
A
V
N
F
E
M
D
E
E
V
A
K
S
L
K
K
-
Y
L
E
V
I
V
A
P
S
F
T
Q
E
A
I
E
V
L
S
K
K
K
--
V
R
L
L
--
K
-
P
G
D
Y
-------
A
S
W
A
G
K
M
A
F
G
S
L
V
L
--
S
E
R
K
Y
---
P
E
G
---
N
F
-
E
L
V
V
G
E
P
-
L
S
E
K
E
L
E
D
--
L
E
F
A
Y
R
V
V
E
G
A
K
S
N
A
V
L
I
A
K
D
G
V
T
V
G
I
G
S
G
Q
P
S
R
K
R
A
A
W
I
A
T
V
M
A
G
E
-----------------------------------------------------------------
K
---
A
K
G
A
V
A
A
S
D
A
F
F
P
F
P
D
S
L
E
I
L
A
Q
A
G
V
K
A
V
V
A
P
L
G
S
I
R
D
E
E
V
I
E
K
A
R
E
L
G
I
T
F
Y
K
A
P
S
R
V
F
R
H
29
PsiBlast_CBE
82.28
37%
-77
- C12 -
1P4R
5
PUR9_HUMAN
B:
[7-462]
----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
I
P
E
D
N
A
D
M
A
R
-
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
Q
S
S
E
--
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
----
F
R
K
Q
Y
S
K
-----
G
-
V
S
Q
----------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
T
L
Q
P
K
L
P
I
T
V
--------
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
---
A
LG
I
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
G
-------------
I
P
L
S
--------------------
E
-
D
E
A
K
V
C
MVYDLYKTLT
P
I
S
-------
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
-
K
K
K
N
G
N
Y
C
--
V
L
Q
M
D
-
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
-
L
H
L
S
Q
K
R
N
N
G
V
V
---
D
K
S
L
-
F
S
N
-
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
--
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
-----------------------------------------------------------------
W
---
W
L
R
H
H
P
Q
V
L
S
M
K
F
K
T
G
V
K
R
A
E
I
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
D
E
D
L
I
K
W
K
A
L
F
E
E
V
P
E
L
L
T
E
A
E
K
K
E
W
7
PsiBlast_PDB
82.15
35%
-83
- C12 -
1ZCZ
3
PUR9_THEMA
A:
[14-464]
--
K
R
I
L
V
S
L
Y
E
K
E
K
Y
L
D
I
L
R
E
L
H
E
K
G
W
E
I
W
A
S
S
G
T
A
K
F
L
K
S
N
G
I
E
A
N
D
V
S
T
I
T
G
F
E
N
L
L
G
G
L
V
K
T
L
H
P
E
I
F
A
G
I
L
G
P
E
P
R
--------------
W
D
V
V
F
V
D
L
Y
P
------
P
P
D
---------
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
W
K
K
V
K
P
A
F
D
M
E
T
L
K
L
A
I
-
E
I
--
D
D
--
E
-------
E
T
R
K
Y
L
A
G
M
T
F
A
F
T
S
V
Y
D
S
I
R
A
N
Q
----
F
V
E
G
I
S
L
-----
A
F
K
R
E
D
L
Q
---------
L
R
Y
G
E
N
P
H
E
K
-
A
F
V
Y
--
G
K
---
P
A
F
-
E
I
L
H
----
E
G
K
T
I
S
F
N
N
I
L
D
A
E
N
A
W
F
M
A
K
N
L
P
R
---
M
---
G
A
V
V
-
V
K
H
Q
S
P
C
----
G
-------------
A
A
I
G
--------------------
E
-
D
----------------
K
V
-------
E
I
V
K
K
A
I
E
A
D
D
E
S
S
F
G
G
I
L
A
V
N
F
E
M
D
E
E
V
A
K
S
L
K
K
-
Y
L
E
V
I
V
A
P
S
F
T
Q
E
A
I
E
V
L
S
K
K
K
--
V
R
L
L
--
K
-
P
G
D
Y
-------
A
S
W
A
G
K
M
A
F
G
S
L
V
L
--
S
E
R
K
Y
---
P
E
G
---
N
F
-
E
L
V
V
G
E
P
-
L
S
E
K
E
L
E
D
--
L
E
F
A
Y
R
V
V
E
G
A
K
S
N
A
V
L
I
A
K
D
G
V
T
V
G
I
G
S
G
Q
P
S
R
K
R
A
A
W
I
A
T
V
M
A
G
E
-----------------------------------------------------------------
K
---
A
K
G
A
V
A
A
S
D
A
F
F
P
F
P
D
S
L
E
I
L
A
Q
A
G
V
K
A
V
V
A
P
L
G
S
I
R
D
E
E
V
I
E
K
A
R
E
L
G
I
T
F
Y
K
A
P
S
R
V
F
R
H
23
PsiBlast_CBE
81.94
37%
-80
- C12 -
1PL0
5
PUR9_HUMAN
D:
[7-462]
----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
I
P
E
D
N
A
D
M
A
R
-
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
QS
S
E
--
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
----
F
R
K
Q
Y
S
K
-----
G
-
V
S
Q
----------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
TL
Q
P
K
L
P
I
T
V
--------
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
---
A
LGI
P
A
A
A
S
F
K
H
V
S
P
A
GAAV
G
-------------
I
P
L
S
--------------------
E
-
D
EAKVCMVYDLYKTLTP
I
S
-------
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
-
K
K
K
N
G
N
Y
C
--
V
L
Q
M
D
-
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
-
L
H
L
S
Q
KR
N
N
G
V
V
---
D
K
S
L
-
F
S
N
-
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
--
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
-----------------------------------------------------------------
W
---
W
L
R
H
H
P
Q
V
L
S
M
I
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
D
E
D
L
I
K
W
K
A
L
F
E
E
V
P
E
L
L
T
E
A
E
K
K
E
W
V
E
K
L
T
E
V
S
I
S
24
PsiBlast_CBE
81.90
37%
-77
- C12 -
1PL0
5
PUR9_HUMAN
C:
[7-462]
----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
I
P
E
D
N
A
D
M
A
R
-
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
QS
S
E
--
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
----
F
R
K
Q
Y
S
K
-----
G
-
V
S
Q
----------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
TL
Q
P
K
L
P
I
T
V
--------
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
---
A
LGI
P
A
A
A
S
F
K
H
V
S
P
A
GAAV
G
-------------
I
P
L
S
--------------------
E
-
D
EAKVCMVYDLYKTLTP
I
S
-------
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
-
K
K
K
N
G
N
Y
C
--
V
L
Q
M
D
-
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
-
L
H
L
S
Q
KR
N
N
G
V
V
---
D
K
S
L
-
F
S
N
-
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
--
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
-----------------------------------------------------------------
W
---
W
L
R
H
H
P
Q
V
L
S
M
K
F
K
T
G
A
E
I
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
D
E
D
L
I
K
W
K
A
L
F
E
E
V
P
E
L
L
T
E
A
E
K
K
E
W
V
E
K
5
PsiBlast_PDB
81.86
37%
-75
- C12 -
1P4R
6
PUR9_HUMAN
A:
[7-462]
----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
I
P
E
D
N
A
D
M
A
R
-
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
Q
S
S
E
--
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
----
F
R
K
Q
Y
S
K
-----
G
-
V
S
Q
----------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
T
L
Q
P
K
L
P
I
T
V
--------
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
---
A
LG
I
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
G
-------------
I
P
L
S
--------------------
E
-
D
E
A
K
V
C
MVYDLYKTLT
P
I
S
-------
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
-
K
K
K
N
G
N
Y
C
--
V
L
Q
M
D
-
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
-
L
H
L
S
Q
K
R
N
N
G
V
V
---
D
K
S
L
-
F
S
N
-
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
--
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
-----------------------------------------------------------------
W
---
W
L
R
H
H
P
Q
V
L
S
M
K
F
K
T
G
V
K
R
A
E
I
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
D
E
D
L
I
K
W
K
A
L
F
E
E
V
P
E
L
L
T
E
A
E
K
K
E
W
6
PsiBlast_PDB
81.57
37%
-81
- C12 -
1PL0
4
PUR9_HUMAN
A:
[7-462]
----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
I
P
E
D
N
A
D
M
A
R
-
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
Q
S
S
E
--
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
----
F
R
K
Q
Y
S
K
-----
G
-
V
S
Q
----------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
T
L
Q
P
K
L
P
I
T
V
--------
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
---
A
L
G
I
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
G
-------------
I
P
L
S
--------------------
E
-
D
E
A
K
V
C
MVYDLYKTLT
P
I
S
-------
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
-
K
K
K
N
G
N
Y
C
--
V
L
Q
M
D
-
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
-
L
H
L
S
Q
K
R
N
N
G
V
V
---
D
K
S
L
-
F
S
N
-
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
--
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
-----------------------------------------------------------------
W
---
W
L
R
H
H
P
Q
V
L
S
M
K
F
K
T
G
V
K
R
A
E
I
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
D
E
D
L
I
K
W
K
A
L
F
E
E
V
P
E
L
L
T
E
A
E
K
K
E
W
25
PsiBlast_CBE
81.52
37%
-79
- C12 -
1PL0
3
PUR9_HUMAN
B:
[7-462]
----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
I
P
E
D
N
A
D
M
A
R
-
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
QS
S
E
--
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
----
F
R
K
Q
Y
S
K
-----
G
-
V
S
Q
----------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
TL
Q
P
K
L
P
I
T
V
--------
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
---
A
LGI
P
A
A
A
S
F
K
H
V
S
P
A
GAAV
G
-------------
I
P
L
S
--------------------
E
-
D
EAKVCMVYDLYKTLTP
I
S
-------
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
-
K
K
K
N
G
N
Y
C
--
V
L
Q
M
D
-
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
-
L
H
L
S
Q
KR
N
N
G
V
V
---
D
K
S
L
-
F
S
N
-
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
--
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
-----------------------------------------------------------------
W
---
W
L
R
H
H
P
Q
V
L
S
M
K
F
K
T
G
V
A
E
I
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
D
E
D
L
I
K
W
K
A
L
F
E
E
V
P
E
L
L
T
E
A
E
K
K
E
W
V
E
4
PsiBlast_PDB
81.40
37%
-78
- C12 -
1PKX
2
PUR9_HUMAN
A:
[7-462]
----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
I
P
E
D
N
A
D
M
A
R
-
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
Q
S
S
E
--
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
----
F
R
K
Q
Y
S
K
-----
G
-
V
S
Q
----------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
T
L
Q
P
K
L
P
I
T
V
--------
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
---
A
LG
I
P
A
A
A
S
F
K
H
V
S
P
A
G
A
A
V
G
-------------
I
P
L
S
--------------------
E
-
D
E
A
K
V
C
MVYDLYKTLT
P
I
S
-------
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
-
K
K
K
N
G
N
Y
C
--
V
L
Q
M
D
-
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
-
L
H
L
S
Q
K
R
N
N
G
V
V
---
D
K
S
L
-
F
S
N
-
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
--
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
-----------------------------------------------------------------
W
---
W
L
R
H
H
P
Q
V
L
S
M
K
F
K
T
G
V
A
E
I
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
D
E
D
L
I
K
W
K
A
L
F
E
E
V
P
E
L
L
T
E
A
E
K
K
E
W
V
E
50
HHSearch
81.39
37%
-86
* C12 *
1ZCZ
3
PUR9_THEMA
A:
[13-464]
-
M
K
R
I
L
V
S
L
Y
E
K
E
K
Y
L
D
I
L
R
E
L
H
E
K
G
W
E
I
W
A
S
S
G
T
A
K
F
L
K
S
N
G
I
E
A
N
D
V
S
T
I
T
G
F
E
N
L
L
G
G
L
V
K
T
L
H
P
E
I
F
A
G
I
L
G
P
E
--------------
P
R
W
D
V
V
F
V
D
L
Y
P
P
---------------
P
D
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
W
K
K
V
K
P
A
F
D
M
E
T
L
K
L
A
I
E
I
------------
D
D
E
E
T
R
K
Y
L
A
G
M
T
F
A
F
T
S
V
Y
D
S
I
R
A
N
Q
----
F
V
E
G
--------------
I
S
L
A
F
K
R
E
D
L
Q
L
R
Y
G
E
N
P
H
E
K
-
A
F
V
Y
--
G
K
P
A
--------
F
E
I
L
H
E
G
K
T
I
S
F
N
N
I
L
D
A
E
N
A
W
F
M
A
K
N
L
P
----
R
---
M
G
A
V
V
V
K
H
Q
S
P
C
----
G
-------------
A
A
I
G
--------------------
E
-
D
----------------
K
V
-------
E
I
V
K
K
A
I
E
A
D
D
E
S
S
F
G
G
I
L
A
V
N
F
E
M
D
E
E
V
A
K
S
L
K
-
K
Y
L
E
V
I
V
A
P
S
F
T
Q
E
A
I
E
V
L
-
S
K
K
K
-
V
R
L
L
--
K
P
G
D
Y
------
A
S
W
A
G
K
M
A
F
G
-
S
L
V
L
S
--
E
R
K
Y
P
------
E
-
G
N
F
-
E
L
V
V
G
E
P
-
L
S
E
K
E
L
E
D
--
L
E
F
A
Y
R
V
V
E
G
A
K
S
N
A
V
L
I
A
K
D
G
V
T
V
G
I
G
S
G
Q
P
S
R
K
R
A
A
W
I
A
T
V
M
A
G
E
-----------------------------------------------------------------
K
---
A
K
G
A
V
A
A
S
D
A
F
F
P
F
P
D
S
L
E
I
L
A
Q
A
G
V
K
A
V
V
A
P
L
G
S
I
R
D
E
E
V
I
E
K
A
R
E
L
G
I
T
F
Y
K
A
P
S
R
V
F
R
H
27
PsiBlast_CBE
81.38
37%
-78
- C12 -
1PKX
2
PUR9_HUMAN
C:
[7-462]
----
A
L
F
S
V
S
D
K
T
G
L
V
E
F
A
R
N
L
T
A
L
G
L
N
L
V
A
S
G
G
T
A
K
A
L
R
D
A
G
L
A
V
R
D
V
S
E
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
I
P
E
D
N
A
D
M
A
R
-
L
D
F
N
L
I
R
V
V
A
C
N
L
Y
P
F
V
K
T
V
A
S
P
G
V
T
V
E
E
A
V
E
Q
I
D
I
G
G
V
T
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
E
P
E
D
Y
V
V
V
S
T
E
M
QS
S
E
--
S
--
K
D
T
S
L
E
T
R
R
Q
L
A
L
K
A
F
T
H
T
A
Q
Y
D
E
A
I
S
D
Y
----
F
R
K
Q
Y
S
K
-----
G
-
V
S
Q
----------
M
P
L
R
Y
G
M
N
P
H
Q
T
P
A
Q
L
Y
TL
Q
P
K
L
P
I
T
V
--------
L
N
G
A
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
E
---
A
LGI
P
A
A
A
S
F
K
H
V
S
P
A
GAAV
G
-------------
I
P
L
S
--------------------
E
-
D
EAKVCMVYDLYKTLTP
I
S
-------
A
A
Y
A
R
A
R
G
A
D
R
M
S
S
F
G
D
F
V
A
L
S
D
V
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
I
I
A
P
G
Y
E
E
E
A
L
T
I
L
S
-
K
K
K
N
G
N
Y
C
--
V
L
Q
M
D
-
Q
S
Y
K
P
D
E
N
E
V
R
T
L
F
G
-
L
H
L
S
Q
KR
N
N
G
V
V
---
D
K
S
L
-
F
S
N
-
V
V
T
K
N
K
D
-
L
P
E
S
A
L
R
D
--
L
I
V
A
T
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
N
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
Y
-----------------------------------------------------------------
W
---
W
L
R
H
H
P
Q
V
L
S
M
K
F
K
T
K
R
A
E
I
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
D
E
D
L
I
K
W
K
A
L
F
E
E
V
P
E
L
L
T
E
A
E
K
K
E
W
V
E
10
PsiBlast_PDB
80.39
35%
-79
- C12 -
1THZ
3
PUR9_CHICK
A:
[8-463]
----
A
L
L
S
V
S
E
K
A
G
L
V
E
F
A
R
S
L
N
A
L
G
L
G
L
I
A
S
G
G
T
A
T
A
L
R
D
A
G
L
P
V
R
D
V
S
D
L
T
G
F
P
E
M
L
G
G
R
V
K
T
L
H
P
A
V
H
A
G
I
L
A
R
N
I
P
E
D
N
A
D
M
N
K
-
Q
D
F
S
L
V
R
V
V
V
C
N
L
Y
P
F
V
K
T
V
S
S
P
G
V
T
V
P
E
A
V
E
K
I
D
I
G
G
V
A
L
L
R
A
A
A
K
N
H
A
R
V
T
V
V
C
D
P
A
D
Y
S
S
V
A
K
E
M
--
A
A
--
S
KD
K
D
T
S
V
E
T
R
R
H
L
A
L
K
A
F
T
H
T
A
Q
Y
D
A
A
I
S
D
Y
----
F
R
K
E
Y
S
K
-----
G
-
V
S
Q
----------
L
P
L
R
Y
G
M
N
P
H
Q
S
P
A
Q
L
Y
T
T
R
P
K
L
P
L
T
V
--------
V
N
G
S
P
-
G
F
I
N
L
C
D
A
L
N
A
W
Q
L
V
K
E
L
K
Q
---
A
LG
I
P
A
A
A
S
F
K
H
V
S
P
A
----
G
A
A
V
GIPLS
E
E
E
A
Q
V
C
M
V
--------------------
H
-
D
----------------
L
H
KTLT
P
L
A
S
A
Y
A
R
S
R
G
A
D
R
M
S
S
F
G
D
F
I
A
L
S
D
I
C
D
V
P
T
A
K
I
I
S
R
E
V
S
D
G
V
V
A
P
G
Y
E
E
E
A
L
K
I
L
S
-
K
K
K
N
G
G
Y
C
--
V
L
Q
M
D
P
N
Y
E
P
D
-
D
N
E
I
R
T
L
Y
G
-
L
Q
L
M
Q
--
K
R
N
N
A
---
V
I
D
R
-
S
L
F
-
K
N
I
V
T
K
N
-
K
T
L
P
E
S
A
V
R
D
L
I
V
A
S
I
A
V
K
Y
T
Q
S
N
S
V
C
Y
A
K
D
G
Q
V
I
G
I
G
A
G
Q
Q
S
R
I
H
C
T
R
L
A
G
D
K
A
N
S
-----------------------------------------------------------------
W
---
W
L
R
H
H
P
R
V
L
S
M
K
F
K
A
G
V
K
R
A
E
V
S
N
A
I
D
Q
Y
V
T
G
T
I
G
E
D
E
D
L
V
K
W
Q
A
M
F
E
E
V
P
A
Q
L
T
E
A
E
K
K
Q
W