@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0035: (2015-11-27 )
MKKKTFSAYNFLTALILCLLTVLFIFPFYWIMTGAFKSQPDTIIIPPQWWPKAPTLENFKALTVQNPALRWLWNSVFISIMTMFLVCCTSSMAGYVLAKKRFYGQKILFSLFIAAMALPKQVVLVPLVRIINFMGIHDTLWAVILPLVGWPFGVFLMKQFSENIPTELLESAKIDGCGEIRTFINVAFPIVKPGFAALAIFTFINTWNDYFMQLVMLTSRNNLTISLGVATMQAEMATNYGLIMAGAALAAVPIVTVFLVFQKSFTQGITMGAVKG
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........-50........60......----..70........80-------------------.........90........100......------.110.....--..120....-..--.130-------------------.-....-----------.-------------------.140....-...--150.......160--....-------------....170.......180.......190.....---..200.......210...-...-------.-220---------........230...--....240..---------......250.......260.......270....----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKK
K
T
F
S
A
Y
N
F
L
T
A
L
I
L
C
L
L
T
V
L
F
I
F
P
F
Y
W
I
MTGAFKSQP
D
T
I
I
IPPQW-WPKAPTLEN
F
K
A
L
TVQN
P
----
A
L
R
W
L
W
N
S
V
F
I
S
I
--------------------
M
T
M
F
L
V
C
CTSSM
A
G
Y
V
L
A
K
K
RFY
G
Q
K
I
L
------
F
S
L
F
I
A
A
MA--LP
K
Q
V
V
L
V
P
-
L
V
--
R
I
I
N
-------------------
F
-MG
I
H
-----------
D
-------------------
T
L
W
A
V
I
L
P
-LVG--
W
P
F
G
V
F
L
M
K
Q
F
S---ENI
P
-------------
T
E
L
L
E
SAKIDG
C
G
E
I
R
T
F
I
N
V
A
F
P
IVKP
G
F
A
A
---
L
A
I
F
T
F
I
N
T
W
N
D
Y
F
M
Q
L
V
-
M
LT-------S-RN----------
N
L
T
I
S
LGV
A
T
M
Q
A
E
--
M
ATNYG-
L
I
---------
M
A
G
A
A
L
A
A
V
P
I
V
T
V
F
L
V
F
Q
K
S
FTQGITMGAVKG----
29
Fugue
87.49
26%
-141
- C5 -
3FH6
-
MALG_ECOLI
G:
[3-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
V
Q
P
K
S
Q
K
A
R
L
F
I
T
H
L
L
L
L
L
F
I
A
A
I
M
F
P
L
L
M
V
V
A
I
S
L
R
Q
R
I
T
P
P
----------------------
P
F
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
------
L
K
G
M
L
I
F
Q
M
--
F
P
A
V
L
S
L
V
A
-
L
Y
--
A
L
F
D
-------------------
R
-
L
G
E
Y
IPFIGL-----
N
-------------------
T
H
G
G
V
I
F
A
Y
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
-------------
9
PsiBlast_PDB
86.20
29%
-141
- C5 -
3RLF
2
MALG_ECOLI
G:
[80-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
G
----
8
PsiBlast_PDB
85.43
29%
-136
- C5 -
3PUX
3
MALG_ECOLI
G:
[80-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
G
----
1
PsiBlast_PDB
85.18
29%
-136
- C5 -
2R6G
-
MALG_ECOLI
G:
[80-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
G
----
12
PsiBlast_PDB
84.53
29%
-136
- C5 -
4KI0
8
?
G:
[80-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
G
----
7
PsiBlast_PDB
84.36
29%
-138
- C5 -
3PUW
5
MALG_ECOLI
G:
[80-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
G
----
6
PsiBlast_PDB
83.96
29%
-138
- C5 -
3PUV
4
MALG_ECOLI
G:
[80-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
G
----
11
PsiBlast_PDB
83.60
29%
-145
- C5 -
4KHZ
1
?
G:
[80-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
-----------------
2
PsiBlast_PDB
83.40
29%
-134
- C5 -
3FH6
-
MALG_ECOLI
G:
[80-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
-------------
5
PsiBlast_PDB
83.13
29%
-144
- C5 -
3PV0
1
MALG_ECOLI
G:
[80-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
-----------------
3
PsiBlast_PDB
83.07
29%
-137
- C5 -
3PUY
-
MALG_ECOLI
G:
[80-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
G
L
T
A
G
G
V
K
G
----
4
PsiBlast_PDB
83.05
29%
-140
- C5 -
3PUZ
1
MALG_ECOLI
G:
[80-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
-----------------
10
PsiBlast_PDB
78.78
29%
-134
- C5 -
4JBW
-
MALG_ECOLI
G:
[80-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
----
V
L
L
W
L
W
N
S
V
K
V
A
G
--------------------
I
S
A
I
G
I
V
A
L
S
T
T
C
A
Y
A
F
A
R
M
R
F
P
G
K
A
T
L
LKGMLI
F
Q
M
F
P
A
V
L
S
--
L
V
A
L
Y
A
L
F
D
R
L
G
--
E
Y
I
P
-------------------
F
-
I
G
L
N
-----------
T
-------------------
H
G
G
V
I
F
A
Y
-
L
G
G
--
I
A
L
H
V
W
T
I
K
G
Y
F
---
E
T
I
D
-------------
S
S
L
E
E
A
A
A
L
D
G
A
T
P
W
Q
A
F
R
L
V
L
L
P
L
S
V
P
I
L
A
V
---
V
F
I
L
S
F
I
A
A
I
T
E
V
P
V
A
S
L
-
L
L
R
-------
D
-
V
N
----------
S
Y
T
L
A
V
G
M
Q
Q
Y
L
N
P
--
Q
N
Y
L
W
G
-
D
F
---------
A
A
A
A
V
M
S
A
L
P
I
T
I
V
F
L
L
A
Q
R
W
L
V
N
-------------
32
Fugue
74.85
16%
-143
- C2 -
4UY5
2
EGTD_MYCS2
A:
[2-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T
L
S
L
A
N
Y
L
A
A
D
S
A
A
E
A
L
R
R
D
V
R
A
G
L
T
A
A
P
K
S
L
P
P
K
W
F
Y
D
A
V
G
S
D
L
F
D
Q
I
T
R
L
P
E
Y
-
Y
P
T
R
T
E
A
Q
I
L
R
T
R
S
A
E
------
I
I
A
A
A
G
A
D
T
L
V
E
L
G
SGT
S
E
K
T
R
M
L
L
D
A
M
R
D
A
EL
L
R
R
F
I
P
F
D
V
D
--
A
G
V
L
R
S
A
G
A
A
I
G
A
E
Y
P
-------
G
I
E
I
D
A
V
C
G
D
F
E
E
H
L
G
K
I
P
-
H
V
GR
R
L
V
V
-------------------
F
-
L
G
------------------------------------
S
T
I
G
N
-
L
T
P
--
A
P
R
A
E
F
L
S
T
L
A
D
---
T
L
Q
P
G
D
S
L
L
L
G
T
D
L
V
K
D
T
G
R
L
V
R
A
Y
D
D
A
A
G
V
T
A
A
F
N
R
N
V
L
A
V
V
N
R
E
L
S
A
DFD
L
D
A
F
E
H
V
A
K
W
N
S
D
E
E
R
I
E
M
W
L
R
-------
A
-
R
T
----------
A
Q
H
V
R
V
A
A
L
D
L
E
V
D
--
F
A
A
G
E
E
M
L
T
E
V
S
C
K
F
R
P
E
N
V
V
A
E
L
A
E
A
G
L
R
Q
T
H
W
W
T
D
P
A
G
D
F
G
L
S
L
A
V
R
L
E
H
H
H
H
20
HHSearch
72.49
15%
-143
- C5 -
2ONK
-
WTPB_ARCFU
C:
[28-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
A
L
L
A
L
L
S
S
I
I
L
L
F
V
L
L
P
V
A
A
T
V
T
L
Q
L
F
------------------
N
F
D
E
F
L
K
A
A
S
D
P
A
----
V
W
K
V
V
L
T
T
Y
Y
A
A
L
--------------------
I
S
T
L
I
A
V
I
F
G
T
P
L
A
Y
I
L
A
R
K
S
F
P
G
K
S
V
V
------
E
G
I
V
D
L
P
V
V
--
I
P
H
T
V
A
G
I
A
-
L
L
--
V
V
F
G
-------------------
S
-
S
G
L
I
-----------
G
SFSPLKFVD----------
A
L
P
G
I
V
V
A
-
M
L
F
VS
V
P
I
Y
I
N
Q
A
K
E
G
F
---
A
S
V
D
-------------
V
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
---
G
A
I
M
S
W
A
R
G
I
S
E
F
G
A
V
V
V
-
I
A
Y
----------
Y
----------
P
M
I
A
P
T
L
I
Y
E
R
Y
L
----
S
E
G
L
S
-
A
A
---------
M
P
V
A
A
I
L
I
L
L
S
L
A
V
F
V
A
L
-
R
I
I
V
G
-------------
22
HHSearch
72.40
18%
-142
* C5 *
3RLF
2
MALF_ECOLI
F:
[258-503]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
G
W
K
N
F
T
R
V
F
T
D
E
G
IQKP
F
L
A
I
F
V
W
T
V
V
F
S
L
--------------------
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
L
V
Q
W
E
A
L
R
G
K
A
V
Y
------
R
V
L
L
I
L
P
Y
A
--
V
P
S
F
I
S
I
L
I
-
F
K
--
G
L
F
N
-------------------
Q
S
F
G
E
I
-----------
N
MMLSALFGVKPAWFSDPTT
A
R
T
M
L
I
I
V
-
N
T
W
LG
Y
P
Y
M
M
I
L
C
M
G
L
L
---
K
A
I
P
-------------
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
---
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
-
L
T
N
-------
G
G
P
D
RLGTTTPAGY
T
D
L
L
V
N
Y
T
Y
R
I
A
F
E
GG
G
G
Q
D
F
G
-
L
A
---------
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
---------------------
31
Fugue
72.23
16%
-140
- C5 -
2ONK
-
WTPB_ARCFU
C:
[24-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
L
F
S
A
L
L
A
L
L
S
S
I
I
L
L
F
V
L
L
P
V
A
A
T
V
T
L
Q
L
F
N
------------------
F
D
E
F
L
K
A
A
S
D
P
A
----
V
W
K
V
V
L
T
T
Y
Y
A
A
L
--------------------
I
S
T
L
I
A
V
I
F
G
T
P
L
A
Y
I
L
A
R
K
S
F
P
G
K
S
V
V
------
E
G
I
V
D
L
P
V
V
--
I
P
H
T
V
A
G
I
A
-
L
L
--
V
V
F
G
-------------------
S
-
S
G
L
I
GSFSPLKFVDA
L
-------------------
P
G
I
V
V
A
M
L
-
F
V
S
--
V
P
I
Y
I
N
Q
A
K
E
G
F
---
A
S
V
D
-------------
V
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
F
T
V
S
L
P
L
S
V
R
H
I
V
A
---
G
A
I
M
S
W
A
R
G
I
S
E
-
F
G
A
V
V
-
V
I
A
-------
Y
-
Y
P
----------
M
I
-----
A
P
T
L
I
Y
E
--
R
Y
L
S
E
G
-
L
S
---------
A
A
M
P
V
A
A
I
L
I
L
L
S
L
A
V
F
V
A
L
R
I
I
V
G
------------
30
Fugue
68.18
16%
-126
- C5 -
4TQU
-
?
N:
[2-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LATP
F
Y
S
R
S
D
R
I
F
G
I
V
N
A
V
L
L
G
I
F
A
L
C
A
L
Y
P
I
I
Y
I
F
S
M
S
I
-
S
S
G
A
A
V
T
Q
G
R
V
F
L
L
P
V
D
I
D
F
S
A
Y
G
R
V
L
H
D
K
L
----
F
W
T
S
Y
A
N
T
I
F
Y
T
V
--------------------
F
G
V
V
T
S
L
I
F
I
V
P
G
A
Y
A
L
S
K
P
R
I
R
G
R
R
V
F
------
G
F
I
I
A
F
T
M
W
--
F
N
A
G
--
M
I
P
-
F
F
--
L
N
M
R
-------------------
D
-
L
G
L
L
-----------
D
-------------------
N
R
F
G
I
L
I
G
-
F
A
C
--
N
A
F
N
I
I
L
M
R
N
Y
F
---
E
S
I
S
-------------
A
S
F
E
E
A
A
R
M
D
G
A
N
D
L
Q
I
L
W
K
V
Y
I
P
L
A
K
P
A
L
A
T
---
I
T
L
L
C
A
I
S
R
W
N
G
Y
F
W
A
M
V
-
L
L
R
-------
A
-
E
E
KIPLQVYLK-
K
T
I
V
D
L
N
V
N
E
E
F
A
G
--
A
L
L
T
N
S
-
Y
S
---------
M
E
T
V
V
G
A
I
I
V
M
S
I
I
P
V
I
I
V
Y
P
V
V
Q
K
Y
F
T
K
--------
33
Fugue
67.10
15%
-130
- C5 -
2R6G
1
MALF_ECOLI
F:
[13-504]
DALKWSVLGLLGLLVGYLVVLMYAQGEYLFAITTLILSSAGLYIFANRKAYAWRYVYPGMAGMGLFVLFPLVCTIAIAFTNYSSTNQLTFERAQEVLLDRSWQAGKTYNFGLYPAGDEWQLALSDGETGKNYLSDAFKFGGEQKLQLKETTAQPEGERANLRVITQNRQALSDITAILPDGNKVMMSSLRQFSGTQ
P
L
Y
T
L
D
G
D
G
T
L
T
N
N
Q
S
G
V
K
Y
R
P
N
N
Q
I
G
F
Y
Q
S
I
T
A
N
W
-
G
D
E
K
L
S
P
G
Y
T
V
T
-
T
G
W
K
N
F
T
R
V
F
T
D
E
G
I
Q
K
P
----
F
L
A
I
F
V
W
T
V
V
F
S
L
--------------------
I
T
V
F
L
T
V
A
V
G
M
V
L
A
C
L
V
Q
W
E
A
L
R
G
K
A
V
Y
------
R
V
L
L
I
L
P
Y
A
--
V
P
S
F
I
S
I
L
I
-
F
K
--
G
L
F
N
QSFGEINMMLSALFGVKPA
W
-
F
S
D
P
-----------
T
-------------------
T
A
R
T
M
L
I
I
-
V
N
T
--
W
L
G
Y
P
Y
M
M
I
L
C
M
GLL
K
A
I
P
-------------
D
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
F
K
I
T
L
P
L
L
I
K
P
L
T
P
---
L
M
I
A
S
F
A
F
N
F
N
N
F
V
L
I
Q
L
-
L
T
N
GGPDRLG
T
-
T
T
----------
P
A
G
Y
T
D
L
L
V
N
Y
T
Y
R
--
I
A
F
E
G
G
-
G
G
---------
Q
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
V
--------------
21
HHSearch
66.39
12%
-131
- C5 -
3D31
-
?
C:
[45-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
V
L
F
L
F
I
F
L
T
L
S
N
M
I
F
E
Q
I
T
-----------------
E
D
F
S
G
L
V
K
A
A
G
N
R
S
----
V
I
S
S
I
F
L
S
L
Y
A
G
F
--------------------
L
A
T
L
L
A
L
L
L
G
A
P
T
G
Y
I
L
A
R
F
D
F
P
G
K
R
L
V
------
E
S
I
I
D
V
P
V
V
--
V
P
H
T
V
A
G
I
A
-
L
L
--
T
V
F
G
-------------------
S
-
R
G
L
I
-----------
G
EPLESYIQFRD--------
A
L
P
G
I
V
V
A
-
M
L
F
VS
M
P
Y
L
A
N
S
A
R
E
G
F
---
K
S
V
D
-------------
P
R
L
E
N
A
A
R
S
L
G
A
P
L
W
K
A
F
F
F
V
T
L
P
L
S
A
R
Y
L
L
I
---
G
S
V
M
T
W
A
R
A
I
S
E
F
G
A
V
V
I
-
L
A
Y
----------
Y
----------
P
M
V
G
P
T
L
I
Y
D
R
F
I
----
S
Y
G
L
S
-
A
S
---------
R
P
I
A
V
L
L
I
L
V
T
L
S
I
F
-
L
V
I
R
-----------------