@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0042: (2015-11-27 )
MKLLVVGSGGREHAIAKKLLASKDVDQVFVAPGNDGMTLDGLDLVNIGISEHSRLIDFAKENEIAWTFIGPDDALAAGIVDDFNSAGLRAFGPTKAAAELEWSKDFAKEIMVKYNVPTAAYGTFSDFEKAKAYIEEQGAPIVVKADGLALGKGVVVAETVEQAVEAAQEMLLDNKFGDSGARVVIEEFLDGEEFSLFAFANGDKFYIMPTAQDHKRAFDGDKGPNTGGMGAYAPVPHLPQSVVDTAVETIIKPVLEGMIAEGRPYLGVLYAGLILTADGPKVIEFNSRFGDPETQIILPRLTSDFAQNIDDIMMGIEPYITWQKDGVTLGVVVASEGYPLDYEKGVPLPEKTDGDIITYYAGAKFAENSKALLSNGGRVYMLVTTEGSVKAGQDKIYTQLAQQDTTGLFYRNDIGSKAIK
Atome Classification :
(20 SA)
.........10.-..-..-.-...20...-.....30......-.-.-40..-.......50........60........70........80........90........100.......110.......120.......130.......140........150.......160.......170.......180.......190.......200.......210.......220.......230.-......240....-....-----250........260.......270.....-..-280.......290.......300.......310.---..--.--...320-----.-.......330...---....340..-----.--..---.---.--350--..---.----......-----360.......370.......380.......390.......400.-......410.......420
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
L
L
V
VGSGG-R-
E
H
-
A
I
-
A
-
K
K
L
L
ASKD-V
D
Q
V
F
V
APGNDG
M
-
T
-L-D-G
L
-
D
L
V
N
IG
I
S
E
H
S
R
L
I
D
F
AKEN
E
I
A
W
T
F
IGP
D
D
A
L
A
A
G
I
VDDFNSAG
L
R
AFGPTK
A
A
A
E
L
E
W
S
K
D
F
A
K
E
I
M
V
K
YNVPTAAYG
T
F
S
D
F
E
K
A
K
A
Y
I
E
EQG
A
P
-
I
V
V
KADGLALGKG
V
V
V
A
E
T
V
E
Q
A
V
E
A
A
Q
E
M
L
L
DNKFGDS
G
A
R
V
V
I
E
E
FLDGE
E
F
S
L
F
A
F
ANG
D
K
F
Y
I
MPTA
Q
D
H
K
RAFDGDKGPNTGGMGAYA-PVPHL
P
Q
-
S
V
V
D
T
-
A
V
E
T
-----
I
-
I
K
P
V
L
E
G
M
IAEGRP
Y
L
G
V
L
Y
A
G
L
I
L
TA-DG-
P
K
V
I
E
FNSRFGDPE
T
Q
I
I
L
P
R
L
T
S
D
F
A
Q
N
I
D
D
I
M
---MG--I--EP
Y
I
-
T
-----
W
-QKD
G
V
T
L
G
V
V
V
AS---EGYPL
D
Y
EK-----G--VP---L---P--E----KT---D----G
D
I
I
T
Y
-----YAGAKFAEN
S
K
A
L
L
SNG
G
R
V
Y
M
L
V
TTEGSVKAG
Q
D
K
I
Y
T
Q
L
AQQ-DTT
G
L
F
Y
RNDIGSKAIK
2
PsiBlast_PDB
93.74
52%
-103
- C1 -
2YRW
1
?
A:
[22-439]
M
N
V
L
V
I
G
R
G
G
-
R
-
E
H
-
A
I
-
A
-
W
K
A
A
Q
S
P
L
-
V
G
K
L
Y
V
A
P
G
N
P
G
I
-
A
---
D
-
V
A
-
E
L
V
H
I
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
------
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
D
-
E
M
M
D
A
-
A
L
E
A
-----
I
-
L
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
-
N
G
-
P
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
L
A
V
M
---
D
G
--
K
--
E
L
E
L
-
E
-----
W
-
T
D
E
A
V
-
L
G
V
V
L
A
A
---
K
G
Y
P
G
A
Y
E
R
-----
G
--
A
E
---
I
---
R
GL
D
----
R
I
---
S
----
P
D
A
L
L
F
-----
H
A
G
T
K
--
R
E
G
G
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
-
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
E
4
PsiBlast_PDB
93.39
52%
-100
- C1 -
2YS6
2
?
A:
[22-439]
M
N
V
L
V
I
G
R
G
G
-
R
-
E
H
-
A
I
-
A
-
W
K
A
A
Q
S
P
L
-
V
G
K
L
Y
V
A
P
G
N
P
G
I
-
A
---
D
-
V
A
-
E
L
V
H
I
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
----
G
K
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
D
-
E
M
M
D
A
-
A
L
E
A
-----
I
-
L
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
-
N
G
-
P
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
L
A
V
M
---
D
G
--
K
--
E
L
E
L
-
E
-----
W
-
T
D
E
A
V
-
L
G
V
V
L
A
A
---
K
G
Y
P
G
A
Y
E
R
-----
G
--
A
E
---
I
---
R
GL
D
----
R
I
---
S
----
P
D
A
L
L
F
-----
H
A
G
T
K
--
R
E
G
G
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
-
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
E
3
PsiBlast_PDB
92.84
52%
-101
- C1 -
2YRX
3
?
A:
[22-438]
M
N
V
L
V
I
G
R
G
G
-
R
-
E
H
-
A
I
-
A
-
W
K
A
A
Q
S
P
L
-
V
G
K
L
Y
V
A
P
G
N
P
G
I
-
A
---
D
-
V
A
-
E
L
V
H
I
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
----
G
K
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
D
-
E
M
M
D
A
-
A
L
E
A
-----
I
-
L
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
-
N
G
-
P
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
L
A
V
M
---
D
G
--
K
--
E
L
E
L
-
E
-----
W
-
T
D
E
A
V
-
L
G
V
V
L
A
A
---
K
G
Y
P
G
A
Y
E
R
-----
G
--
A
E
---
I
---
R
GL
D
----
R
I
---
S
----
P
D
A
L
L
F
-----
H
A
G
T
K
--
R
E
G
G
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
-
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
-
6
PsiBlast_PDB
90.65
51%
-88
- C1 -
2XCL
2
PUR2_BACSU
A:
[3-418]
--
V
L
I
I
G
K
G
G
-
R
-
E
H
-
T
L
-
A
-
W
K
A
A
Q
S
S
L
-
V
E
N
V
F
A
A
P
G
N
D
G
M
-
A
-
A
-
S
-
A
--
Q
L
V
N
I
E
E
S
D
H
A
G
L
V
S
F
A
K
Q
N
Q
V
G
L
T
I
V
G
P
E
V
P
L
I
E
G
L
V
D
E
F
E
K
A
G
L
H
V
F
G
P
S
K
A
A
A
I
I
E
G
S
K
Q
F
A
K
D
L
M
K
K
Y
D
I
P
T
A
E
Y
E
T
F
T
S
F
D
E
A
K
A
Y
V
Q
E
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
T
V
A
M
T
E
E
E
A
I
A
C
L
H
D
F
L
E
D
E
K
F
G
D
A
S
A
S
V
V
I
E
E
Y
L
S
G
E
E
F
S
L
M
A
F
V
K
G
E
K
V
Y
P
M
V
I
A
Q
D
H
K
R
A
F
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
E
-
E
T
V
R
H
-
A
V
E
T
-----
I
-
V
K
P
A
A
K
A
M
V
Q
E
G
R
S
F
T
G
V
L
Y
A
G
L
M
L
T
E
-
N
G
-
S
K
V
I
E
F
N
A
R
F
G
D
P
E
T
Q
V
V
L
P
R
M
E
S
D
L
V
Q
V
L
L
D
L
L
---
D
D
--
K
--
E
V
D
L
-
R
-----
W
--
K
D
T
A
A
V
S
V
V
L
A
S
---
E
G
Y
P
E
S
Y
A
K
-----
G
--
T
P
IGS
L
---
A
--
A
----
E
T
---
E
-----
Q
V
V
V
F
-----
H
A
G
T
K
-
A
E
G
G
E
-
F
V
T
N
G
G
R
V
A
N
V
T
A
F
D
E
T
F
E
A
A
R
D
R
V
Y
K
A
V
D
E
I
-
F
K
P
G
L
F
F
R
K
D
I
G
A
R
A
L
K
1
PsiBlast_PDB
90.16
52%
-85
- C1 -
2XD4
4
PUR2_BACSU
A:
[1-418]
M
N
V
L
I
I
G
K
G
G
-
R
-
E
H
-
T
L
-
A
-
W
K
A
A
Q
S
S
L
-
V
E
N
V
F
A
A
P
G
N
D
G
M
-
A
-
A
-
S
-
A
--
Q
L
V
N
I
E
E
S
D
H
A
G
L
V
S
F
A
K
Q
N
Q
V
G
L
T
I
V
G
P
E
V
P
L
I
E
G
L
V
D
E
F
E
K
A
G
L
H
V
F
G
P
S
K
A
A
A
I
I
E
G
S
K
Q
F
A
K
D
L
M
K
K
Y
D
I
P
T
A
E
Y
E
T
F
T
S
F
D
E
A
K
A
Y
V
Q
E
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
T
V
A
M
T
E
E
E
A
I
A
C
L
H
D
F
L
E
D
E
K
F
G
D
A
S
A
S
V
V
I
E
E
Y
L
S
G
E
E
F
S
L
M
A
F
V
K
G
E
K
V
Y
P
M
V
I
A
Q
D
H
K
R
A
F
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
E
-
E
T
V
R
H
-
A
V
E
T
-----
I
-
V
K
P
A
A
K
A
M
V
Q
E
G
R
S
F
T
G
V
L
Y
A
G
L
M
L
T
E
-
N
G
-
S
K
V
I
E
F
N
A
R
F
G
D
P
E
T
Q
V
V
L
P
R
M
E
S
D
L
V
Q
V
L
L
D
L
L
---
D
D
--
K
--
E
V
D
L
-
R
-----
W
--
K
D
T
A
A
V
S
V
V
L
A
S
---
E
G
Y
P
E
S
Y
A
K
-----
G
--
T
P
IGS
L
---
A
--
A
----
E
T
---
E
-----
Q
V
V
V
F
-----
H
A
G
T
K
-
A
E
G
G
E
-
F
V
T
N
G
G
R
V
A
N
V
T
A
F
D
E
T
F
E
A
A
R
D
R
V
Y
K
A
V
D
E
I
-
F
K
P
G
L
F
F
R
K
D
I
G
A
R
A
L
K
21
PsiBlast_CBE
88.64
46%
-88
- C1 -
2YW2
2
PUR2_AQUAE
B:
[1-420]
M
K
V
L
V
V
G
N
G
G
-
R
-
E
H
-
A
I
-
A
-
W
K
V
A
Q
S
P
L
-
V
K
E
L
Y
V
A
K
G
N
A
G
I
---
W
-
E
-
I
A
-
K
R
V
D
I
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
T
P
V
I
N
E
-
E
V
E
K
R
-
I
R
E
E
-----
I
-
V
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
-
E
G
-
P
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
L
N
F
Y
---
E
G
--
K
--
D
V
H
I
-
K
-------
E
D
E
R
Y
A
L
D
V
V
L
A
S
---
R
G
Y
P
E
K
P
E
T
-----
G
--
K
I
---
I
---
H
--
G
LDYL
K
S
---
M
----
E
D
V
V
V
F
-----
H
A
G
T
K
K
E
G
N
--
F
T
V
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
-
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
9
PsiBlast_PDB
88.48
46%
-89
- C1 -
2YYA
-
PUR2_AQUAE
A:
[1-420]
M
K
V
L
V
V
G
N
G
G
-
R
-
E
H
-
A
I
-
A
-
W
K
V
A
Q
S
P
L
-
V
K
E
L
Y
V
A
K
G
N
A
G
I
---
W
-
E
-
I
A
-
K
R
V
D
I
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
T
P
V
I
N
E
-
E
V
E
K
R
-
I
R
E
E
-----
I
-
V
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
-
E
G
-
P
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
L
N
F
Y
---
E
G
--
K
--
D
V
H
I
-
K
-------
E
D
E
R
Y
A
L
D
V
V
L
A
S
---
R
G
Y
P
E
K
P
E
T
-----
G
--
K
I
---
I
---
H
--
G
L
D
Y
L
K
S
---
M
----
E
D
V
V
V
F
-----
H
A
G
T
K
K
E
G
N
--
F
T
V
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
-
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
10
PsiBlast_PDB
88.45
44%
-98
- C1 -
2QK4
5
PUR2_HUMAN
A:
[26-448]
-
R
V
L
I
I
G
S
G
G
-
R
-
E
H
-
T
L
-
A
-
W
K
L
A
Q
S
H
H
-
V
K
Q
V
L
V
A
P
G
N
A
G
T
-
A
-
C
S
E
-
K
I
-
S
N
T
A
I
S
I
S
D
H
T
A
L
A
Q
F
C
K
E
K
K
I
E
F
V
V
V
G
P
E
A
P
L
A
A
G
I
V
G
N
L
R
S
A
G
V
Q
C
F
G
P
T
A
E
A
A
Q
L
E
S
S
K
R
F
A
K
E
F
M
D
R
H
G
I
P
T
A
Q
W
K
A
F
T
K
P
E
E
A
C
S
F
I
L
S
A
D
F
P
A
L
V
V
K
A
S
G
L
---
K
G
V
I
V
A
K
S
K
E
E
A
C
K
A
V
Q
E
I
M
Q
E
-------
E
T
I
V
I
E
E
L
L
D
G
E
E
V
S
C
L
C
F
T
D
G
K
T
V
A
P
M
P
P
A
Q
D
H
K
R
L
L
E
G
D
G
G
P
N
T
G
G
M
G
A
Y
C
-
P
A
P
Q
V
S
N
-
D
L
L
L
K
-
I
K
D
T
-----
V
-
L
Q
R
T
V
D
G
M
Q
Q
E
G
T
P
Y
T
G
I
L
Y
A
G
I
M
L
T
K
-
N
G
-
P
K
V
L
E
F
N
C
R
F
G
D
P
E
C
Q
V
I
L
P
L
L
K
S
D
L
Y
E
V
I
Q
S
T
L
---
D
G
--
L
LC
T
S
L
P
-
V
-----
W
-
L
E
N
H
T
A
L
T
V
V
M
A
S
---
K
G
Y
P
G
D
Y
T
K
-----
G
--
V
E
---
I
T
G
F
P
--
E
----
A
Q
---
A
----
L
G
L
E
V
F
-----
H
A
G
T
A
L
-
K
N
G
K
-
V
V
T
H
G
G
R
V
L
A
V
T
A
I
R
E
N
L
I
S
A
L
E
E
A
K
K
G
L
A
A
I
-
K
F
E
G
A
I
Y
R
K
D
I
G
F
R
A
I
A
8
PsiBlast_PDB
87.53
46%
-88
- C1 -
2YW2
2
PUR2_AQUAE
A:
[1-420]
M
K
V
L
V
V
G
N
G
G
-
R
-
E
H
-
A
I
-
A
-
W
K
V
A
Q
S
P
L
-
V
K
E
L
Y
V
A
K
G
N
A
G
I
---
W
-
E
-
I
A
-
K
R
V
D
I
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
T
P
V
I
N
E
-
E
V
E
K
R
-
I
R
E
E
-----
I
-
V
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
-
E
G
-
P
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
L
N
F
Y
---
E
G
--
K
--
D
V
H
I
-
K
-------
E
D
E
R
Y
A
L
D
V
V
L
A
S
---
R
G
Y
P
E
K
P
E
T
-----
G
--
K
I
---
I
---
H
--
G
L
D
Y
L
K
S
---
M
----
E
D
V
V
V
F
-----
H
A
G
T
K
K
E
G
N
--
F
T
V
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
-
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
25
HHSearch
86.52
49%
-86
- C1 -
2XCL
2
PUR2_BACSU
A:
[1-418]
M
N
V
L
I
I
G
K
G
G
-
R
-
E
H
-
T
L
A
W
-
K
A
A
Q
S
--
S
-
L
V
E
N
V
F
A
A
P
G
-
N
D
-
G
-
M
-
A
A
S
A
-
Q
L
V
N
I
E
E
S
D
H
A
G
L
V
S
F
A
K
Q
N
Q
V
G
L
T
I
V
G
P
E
V
P
L
I
E
G
L
V
D
E
F
E
K
A
G
L
H
V
F
G
P
S
K
A
A
A
I
I
E
G
S
K
Q
F
A
K
D
L
M
K
K
Y
D
I
P
T
A
E
Y
E
T
F
T
S
F
D
E
A
K
A
Y
V
Q
E
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
T
V
A
M
T
E
E
E
A
I
A
C
L
H
D
F
L
E
D
E
K
F
G
D
A
S
A
S
V
V
I
E
E
Y
L
S
G
E
E
F
S
L
M
A
F
V
K
G
E
K
V
Y
P
M
V
I
A
Q
D
H
K
R
A
F
D
G
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
E
E
T
V
R
H
A
-
V
E
-
T
-----
I
-
V
K
P
A
A
K
A
M
V
Q
E
G
R
S
F
T
G
V
L
Y
A
G
L
M
L
T
E
-
N
G
-
S
K
V
I
E
F
N
A
R
F
G
D
P
E
T
Q
V
V
L
P
R
M
E
S
D
L
V
Q
V
L
L
D
L
L
---
D
D
--
K
--
E
V
D
L
-
R
-----
W
-
K
D
T
-
A
A
V
S
V
V
L
A
S
---
E
G
Y
P
E
S
Y
A
K
-----
G
--
T
P
---
I
---
G
--
S
----
L
A
---
A
ET--
E
Q
V
V
V
F
-----
H
A
G
T
K
A
E
-
G
-
G
E
F
V
T
N
G
G
R
V
A
N
V
T
A
F
D
E
T
F
E
A
A
R
D
R
V
Y
K
A
V
D
E
I
-
F
K
P
G
L
F
F
R
K
D
I
G
A
R
A
L
K
26
HHSearch
85.87
49%
-92
- C1 -
2YRX
3
?
A:
[22-438]
M
N
V
L
V
I
G
R
G
G
R
E
-
H
A
-
I
A
-
W
-
K
A
A
Q
S
--
P
-
L
V
G
K
L
Y
V
A
P
G
N
P
G
-
I
-
A
-
D
-
V
A
-
E
L
V
H
I
D
E
L
D
I
E
A
L
V
Q
F
A
K
Q
Q
A
I
D
L
T
I
V
G
P
E
A
P
L
A
S
G
I
V
D
R
F
M
A
E
G
L
R
I
F
G
P
S
Q
R
A
A
L
I
E
G
S
K
A
F
A
K
E
L
M
K
K
Y
G
I
P
T
A
D
H
A
A
F
T
S
Y
E
E
A
K
A
Y
I
E
Q
K
G
A
P
-
I
V
I
K
A
D
----
G
K
G
V
T
V
A
Q
T
V
E
E
A
L
A
A
A
K
A
A
L
V
D
G
Q
F
G
T
A
G
S
Q
V
V
I
E
E
Y
L
E
G
E
E
F
S
F
M
A
F
V
N
G
E
K
V
Y
P
L
A
I
A
Q
D
H
K
R
A
Y
D
G
D
E
G
P
N
T
G
G
M
G
A
Y
S
-
P
V
P
Q
I
S
D
-
E
M
M
D
A
A
L
E
-
A
-----
I
-
L
R
P
A
A
K
A
L
A
A
E
G
R
P
F
L
G
V
L
Y
A
G
L
M
A
T
A
-
N
G
-
P
K
V
I
E
F
N
A
R
F
G
D
P
E
A
Q
V
V
L
P
R
L
K
T
D
L
V
E
A
V
L
A
V
M
---
D
G
--
K
--
E
L
E
L
-
E
-----
W
-
T
D
E
-
A
V
L
G
V
V
L
A
A
---
K
G
Y
P
G
A
Y
E
R
-----
G
--
A
E
---
I
---
R
--
G
----
L
D
---
R
IS--
P
D
A
L
L
F
-----
H
A
G
T
K
R
E
G
--
G
A
W
Y
T
N
G
G
R
V
L
L
L
A
A
K
G
E
T
L
A
K
A
K
E
K
A
Y
E
Q
L
A
A
I
-
D
C
D
G
L
F
Y
R
R
D
I
G
R
R
A
I
-
11
PsiBlast_PDB
84.15
45%
-91
- C1 -
3MJF
12
PUR2_YERPE
A:
[5-427]
-
N
I
L
I
I
G
N
G
G
-
R
-
E
H
-
A
L
-
G
-
W
K
A
A
Q
S
P
L
-
A
D
K
I
Y
V
A
P
G
N
A
G
T
-
A
-
L
-
E
P
T
L
-
E
N
V
D
I
A
A
T
D
I
A
G
L
L
A
F
A
Q
S
H
D
I
G
L
T
I
V
G
P
E
A
P
L
V
I
G
V
V
D
A
F
R
A
A
G
L
A
I
F
G
P
T
Q
A
A
A
Q
L
E
G
S
K
A
F
T
K
D
F
L
A
R
H
N
I
P
S
A
E
Y
Q
N
F
T
D
V
E
A
A
L
A
Y
V
R
Q
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
I
V
A
M
T
Q
E
E
A
E
T
A
V
N
D
M
L
A
G
N
A
F
G
D
A
G
H
R
I
V
V
E
E
F
L
D
G
E
E
A
S
F
I
V
M
V
D
G
E
N
V
L
P
M
A
T
S
Q
D
H
K
R
V
G
D
G
D
T
G
P
N
T
G
G
M
G
A
Y
S
-
P
A
P
V
V
T
D
-
D
V
H
Q
R
-
V
M
D
Q
-----
V
-
I
W
P
T
V
R
G
M
A
A
E
G
N
I
Y
T
G
F
L
Y
A
G
L
M
I
S
A
-
D
G
Q
P
K
V
I
E
F
N
C
R
F
G
D
P
E
T
Q
P
I
M
L
R
M
R
S
D
L
---
V
E
L
C
L
---
A
G
--
T
--
Q
G
K
L
-
N
E
K
T
S
D
W
-
D
E
R
-
P
S
L
G
V
V
L
A
A
---
G
G
Y
P
A
D
Y
R
Q
G
D
V
I
H
G
--
L
P
---
Q
---
Q
--
E
----
V
K
---
D
----
G
K
V
--
F
-----
H
A
G
T
K
L
N
G
N
H
E
-
V
V
T
N
G
G
R
V
-
L
C
V
T
A
L
G
E
T
V
A
Q
A
Q
Q
Y
A
Y
Q
L
A
E
G
I
Q
W
E
G
V
F
C
R
K
D
I
G
Y
R
A
I
A
29
HHSearch
83.23
42%
-89
- C1 -
2QK4
5
PUR2_HUMAN
A:
[25-448]
A
R
V
L
I
I
G
S
G
G
-
R
-
E
H
-
T
L
-
A
W
K
L
A
Q
S
--
H
-
H
V
K
Q
V
L
V
A
P
G
N
A
G
-
T
A
C
-
S
E
K
I
-
S
N
T
A
I
S
I
S
D
H
T
A
L
A
Q
F
C
K
E
K
K
I
E
F
V
V
V
G
P
E
A
P
L
A
A
G
I
V
G
N
L
R
S
A
G
V
Q
C
F
G
P
T
A
E
A
A
Q
L
E
S
S
K
R
F
A
K
E
F
M
D
R
H
G
I
P
T
A
Q
W
K
A
F
T
K
P
E
E
A
C
S
F
I
L
S
A
D
F
P
A
L
V
V
K
A
S
G
L
---
K
G
V
I
V
A
K
S
K
E
E
A
C
K
A
V
Q
E
I
M
Q
E
-------
E
T
I
V
I
E
E
L
L
D
G
E
E
V
S
C
L
C
F
T
D
G
K
T
V
A
P
M
P
P
A
Q
D
H
K
R
L
L
E
G
D
G
G
P
N
T
G
G
M
G
A
Y
C
-
P
A
P
Q
V
S
N
-
D
L
L
L
K
-
I
K
-
D
-----
T
V
L
Q
R
T
V
D
G
M
Q
Q
E
G
T
P
Y
T
G
I
L
Y
A
G
I
M
L
T
K
-
N
G
-
P
K
V
L
E
F
N
C
R
F
G
D
P
E
C
Q
V
I
L
P
L
L
K
S
D
L
Y
E
V
I
Q
S
T
L
---
D
G
--
L
--
L
C
T
S
L
P
V
----
W
-
L
E
N
H
T
A
L
T
V
V
M
A
S
---
K
G
Y
P
G
D
Y
T
K
-----
G
--
V
E
---
I
---
T
--
G
----
F
P
---
E
A
Q
A
-
L
G
L
E
V
F
-----
H
A
G
T
A
L
K
N
--
G
K
V
V
T
H
G
G
R
V
L
A
V
T
A
I
R
E
N
L
I
S
A
L
E
E
A
K
K
G
L
A
A
I
-
K
F
E
G
A
I
Y
R
K
D
I
G
F
R
A
I
A
12
PsiBlast_PDB
83.12
39%
-94
- C1 -
3LP8
6
?
A:
[22-440]
M
N
V
L
V
I
G
S
G
G
-
R
-
E
H
-
S
M
-
L
-
H
H
I
R
K
S
T
L
-
L
N
K
L
F
I
A
P
G
R
E
G
M
-
S
-----
G
L
A
D
I
I
D
I
D
I
N
S
T
I
E
V
I
Q
V
C
K
K
E
K
I
E
L
V
V
I
G
P
E
T
P
L
M
N
G
L
S
D
A
L
T
E
E
G
I
L
V
F
G
P
S
K
A
A
A
R
L
E
S
S
K
G
F
T
K
E
L
C
M
R
Y
G
I
P
T
A
K
Y
G
Y
F
V
D
T
N
S
A
Y
K
F
I
D
K
H
K
L
P
-
L
V
V
K
A
D
G
L
A
Q
G
K
G
T
V
I
C
H
T
H
E
E
A
Y
N
A
V
D
A
M
L
V
H
H
K
F
G
E
A
G
C
A
I
I
I
E
E
F
L
E
G
K
E
I
S
F
F
T
L
V
D
G
S
N
P
V
I
L
G
V
A
Q
D
Y
K
T
I
G
D
N
N
K
G
P
N
T
G
G
M
G
S
Y
S
-
K
P
N
I
I
T
Q
-
E
M
E
H
I
-
I
I
Q
K
-----
I
-
I
Y
P
T
I
K
A
M
F
N
M
N
I
Q
F
R
G
L
L
F
A
G
I
I
I
K
K
-
N
E
-
P
K
L
L
E
Y
N
V
R
F
G
D
P
E
T
Q
S
I
L
P
R
L
N
S
D
F
L
K
L
L
S
L
T
A
K
GK
L
G
--
N
--
E
S
V
E
-
L
-----
S
-
K
K
--
A
A
L
C
V
V
V
A
S
---
R
G
Y
P
G
E
Y
K
K
N
S
I
I
N
G
--
I
E
---
N
---
I
--
E
----
K
L
---
P
-----
N
V
Q
L
L
-----
H
A
G
T
R
R
E
G
N
N
--
W
V
S
D
S
G
R
V
I
N
V
V
A
Q
G
E
N
L
A
S
A
K
H
Q
A
Y
A
A
L
D
L
L
-
D
W
P
D
G
I
Y
R
Y
D
I
G
S
C
---
27
HHSearch
82.20
44%
-83
- C1 -
2YW2
2
PUR2_AQUAE
A:
[1-420]
M
K
V
L
V
V
G
N
G
G
-
R
E
H
A
-
I
A
-
W
-
K
V
A
Q
S
--
P
-
L
V
K
E
L
Y
V
A
K
G
N
A
G
-
I
-
W
-
E
I
A
K
-
R
-
V
D
I
S
P
T
D
V
E
K
L
A
E
F
A
K
N
E
G
V
D
F
T
I
V
G
P
E
A
P
L
V
E
G
I
V
D
E
F
E
K
R
G
L
K
I
F
G
P
N
K
E
A
A
K
L
E
G
S
K
A
F
A
K
T
F
M
K
K
Y
G
I
P
T
A
R
Y
E
V
F
T
D
F
E
K
A
K
E
Y
V
E
K
V
G
A
P
-
I
V
V
K
A
D
G
L
A
A
G
K
G
A
V
V
C
E
T
V
E
K
A
I
E
T
L
D
R
F
L
N
K
K
I
F
G
K
S
S
E
R
V
V
I
E
E
F
L
E
G
E
E
A
S
Y
I
V
M
I
N
G
D
R
Y
V
P
L
P
T
S
Q
D
H
K
R
L
L
D
E
D
K
G
P
N
T
G
G
M
G
A
Y
S
-
P
T
P
V
I
N
E
-
E
V
E
K
R
-
I
R
E
E
-----
I
-
V
E
R
V
I
K
G
L
K
E
E
G
I
Y
Y
R
G
F
L
Y
A
G
L
M
I
T
K
-
E
G
-
P
K
V
L
E
F
N
V
R
L
G
D
P
E
A
Q
P
I
L
M
R
V
K
N
D
F
L
E
T
L
L
N
F
Y
---
E
G
--
K
--
D
V
H
I
-
K
-----
E
-
D
E
R
-
Y
A
L
D
V
V
L
A
S
---
R
G
Y
P
E
K
P
E
T
-----
G
--
K
I
---
I
---
H
--
G
----
L
D
---
Y
L
K
S
M
E
D
V
V
V
F
H
A
GTK
K
E
G
N
F
T
-------
V
T
S
G
G
R
V
L
N
V
C
A
Y
G
K
T
L
K
E
A
K
E
R
A
Y
E
A
I
R
Y
V
-
C
F
E
G
M
H
Y
R
K
D
I
G
D
K
A
F
K
13
PsiBlast_PDB
80.65
41%
-89
- C1 -
2IP4
2
?
A:
[2-412]
-
K
V
L
V
V
G
S
G
G
-
R
-
E
H
-
A
L
-
L
-
W
K
A
A
Q
S
P
R
-
V
K
R
L
Y
A
A
P
G
N
A
G
M
-----
E
-
A
L
-
A
E
L
V
P
W
N
G
D
V
E
A
L
A
D
W
A
L
A
E
G
I
D
L
T
L
V
G
P
E
A
P
L
V
E
G
I
A
D
A
F
Q
A
R
G
L
L
L
F
G
P
T
Q
K
A
A
M
I
E
G
S
K
A
F
A
K
G
L
M
E
R
Y
G
I
P
T
A
R
Y
R
V
F
R
E
P
L
E
A
L
A
Y
L
E
E
V
G
V
P
-
V
V
V
K
D
S
G
L
A
A
G
K
G
V
T
V
A
F
D
L
H
Q
A
K
Q
A
V
A
N
I
L
--
N
R
--
A
E
G
G
E
V
V
V
E
E
Y
L
E
G
E
E
A
T
V
L
A
L
T
D
G
E
T
I
L
P
L
L
P
S
Q
D
H
K
R
L
L
D
G
D
Q
G
P
M
T
G
G
M
G
A
V
A
-
P
Y
P
M
-
D
E
-
A
T
L
R
R
-
V
E
E
E
-----
I
-
L
G
P
L
V
R
G
L
R
A
E
G
V
V
Y
R
G
V
V
Y
A
G
L
M
L
T
R
-
E
G
-
P
K
V
L
E
F
N
A
R
F
G
D
P
E
A
Q
A
L
L
P
L
L
E
N
D
L
V
E
L
A
L
R
V
A
---
E
G
RL
A
--
G
T
R
L
-
S
-----
W
--
K
E
G
A
A
A
C
V
V
L
A
A
---
P
G
Y
P
E
S
P
R
K
-----
G
--
I
P
---
L
H
V
-
P
--
E
----
P
P
---
E
----
G
-
V
L
V
F
-----
H
A
G
T
R
--
R
E
G
G
R
L
V
S
A
G
G
R
V
L
N
V
V
G
L
G
R
D
L
K
E
A
L
E
R
A
Y
A
Y
I
P
Q
V
-
G
F
P
G
A
V
Y
R
R
D
I
G
R
R
A
L
A
30
HHSearch
79.35
43%
-86
- C1 -
3MJF
12
PUR2_YERPE
A:
[4-427]
M
N
I
L
I
I
G
N
G
G
-
R
-
E
H
A
L
G
-
W
-
K
A
A
Q
S
--
P
-
L
A
D
K
I
Y
V
A
P
G
N
A
G
T
A
-
L
-
E
P
T
L
-
E
N
V
D
I
A
A
T
D
I
A
G
L
L
A
F
A
Q
S
H
D
I
G
L
T
I
V
G
P
E
A
P
L
V
I
G
V
V
D
A
F
R
A
A
G
L
A
I
F
G
P
T
Q
A
A
A
Q
L
E
G
S
K
A
F
T
K
D
F
L
A
R
H
N
I
P
S
A
E
Y
Q
N
F
T
D
V
E
A
A
L
A
Y
V
R
Q
K
G
A
P
-
I
V
I
K
A
D
G
L
A
A
G
K
G
V
I
V
A
M
T
Q
E
E
A
E
T
A
V
N
D
M
L
A
G
N
A
F
G
D
A
G
H
R
I
V
V
E
E
F
L
D
G
E
E
A
S
F
I
V
M
V
D
G
E
N
V
L
P
M
A
T
S
Q
D
H
K
R
V
G
D
G
D
T
G
P
N
T
G
G
M
G
A
Y
S
-
P
A
P
V
V
T
D
-
D
V
H
Q
R
-
V
M
-
D
QV
I
W
P
T
-
V
R
G
M
A
A
E
G
N
---
I
-
Y
T
G
F
L
Y
A
G
L
M
I
S
A
D
G
Q
-
P
K
V
I
E
F
N
C
R
F
G
D
P
E
T
Q
P
I
M
L
R
M
R
S
D
L
V
E
L
C
L
A
G
T
---
Q
G
--
K
--
L
N
E
K
-
T
S
D
---
W
-
D
E
R
-
P
S
L
G
V
V
L
A
A
---
G
G
Y
P
A
D
Y
R
Q
-----
G
--
D
V
---
I
---
H
--
G
----
L
P
---
Q
QEV-
K
D
G
K
V
F
-----
H
A
G
T
K
L
N
G
N
-
H
E
V
V
T
N
G
G
R
V
L
C
V
T
A
L
G
E
T
V
A
Q
A
Q
Q
Y
A
Y
Q
L
A
E
G
I
-
Q
W
E
G
V
F
C
R
K
D
I
G
Y
R
A
I
A
31
HHSearch
77.72
37%
-83
- C1 -
3LP8
6
?
A:
[22-440]
M
N
V
L
V
I
G
S
G
G
-
R
-
E
H
-
S
M
-
L
-
H
H
I
R
K
--
S
T
L
L
N
K
L
F
I
A
P
G
R
E
G
-
M
-
S
-
G
L
A
D
--
I
I
D
I
D
I
N
S
T
I
E
V
I
Q
V
C
K
K
E
K
I
E
L
V
V
I
G
P
E
T
P
L
M
N
G
L
S
D
A
L
T
E
E
G
I
L
V
F
G
P
S
K
A
A
A
R
L
E
S
S
K
G
F
T
K
E
L
C
M
R
Y
G
I
P
T
A
K
Y
G
Y
F
V
D
T
N
S
A
Y
K
F
I
D
K
H
K
L
P
-
L
V
V
K
A
D
G
L
A
Q
G
K
G
T
V
I
C
H
T
H
E
E
A
Y
N
A
V
D
A
M
L
V
H
H
K
F
G
E
A
G
C
A
I
I
I
E
E
F
L
E
G
K
E
I
S
F
F
T
L
V
D
G
S
N
P
V
I
L
G
V
A
Q
D
Y
K
T
I
G
D
N
N
K
G
P
N
T
G
G
M
G
S
Y
S
K
P
N
I
I
-
T
Q
-
E
M
E
H
I
-
I
I
Q
K
-----
I
-
I
Y
P
T
I
K
A
M
F
N
M
N
I
Q
F
R
G
L
L
F
A
G
I
I
I
K
K
-
N
E
-
P
K
L
L
E
Y
N
V
R
F
G
D
P
E
T
Q
S
I
L
P
R
L
N
S
D
F
L
K
L
L
S
L
T
A
---
K
G
--
K
--
L
G
N
E
-
S
-----
V
E
L
S
K
K
A
A
L
C
V
V
V
A
S
RGY
P
G
E
Y
K
K
--------
N
--
S
I
---
I
---
N
--
G
----
I
E
N
I
E
K
L---
P
N
V
Q
L
L
-----
H
A
G
T
R
R
E
G
--
N
N
W
V
S
D
S
G
R
V
I
N
V
V
A
Q
G
E
N
L
A
S
A
K
H
Q
A
Y
A
A
L
D
L
L
-
D
W
P
D
G
I
Y
R
Y
D
I
G
S
C
---
28
HHSearch
76.67
41%
-84
- C1 -
2IP4
2
?
A:
[1-412]
M
K
V
L
V
V
G
S
G
G
-
R
-
E
H
-
A
L
L
W
-
K
A
A
Q
S
--
P
-
R
V
K
R
L
Y
A
A
P
G
N
A
G
-
M
-
E
-
A
-
L
A
-
E
-
L
V
P
W
N
G
D
V
E
A
L
A
D
W
A
L
A
E
G
I
D
L
T
L
V
G
P
E
A
P
L
V
E
G
I
A
D
A
F
Q
A
R
G
L
L
L
F
G
P
T
Q
K
A
A
M
I
E
G
S
K
A
F
A
K
G
L
M
E
R
Y
G
I
P
T
A
R
Y
R
V
F
R
E
P
L
E
A
L
A
Y
L
E
E
V
G
V
P
-
V
V
V
K
D
S
G
L
A
A
G
K
G
V
T
V
A
F
D
L
H
Q
A
K
Q
A
V
A
N
I
L
N
R
----
A
E
G
G
E
V
V
V
E
E
Y
L
E
G
E
E
A
T
V
L
A
L
T
D
G
E
T
I
L
P
L
L
P
S
Q
D
H
K
R
L
L
D
G
D
Q
G
P
M
T
G
G
M
G
A
V
A
-
P
Y
P
M
-
D
E
-
A
T
L
R
R
-
V
E
E
E
-----
I
-
L
G
P
L
V
R
G
L
R
A
E
G
V
V
Y
R
G
V
V
Y
A
G
L
M
L
T
R
-
E
G
-
P
K
V
L
E
F
N
A
R
F
G
D
P
E
A
Q
A
L
L
P
L
L
E
N
D
L
V
E
L
A
L
R
V
A
---
E
G
--
R
--
L
A
G
T
-
R
-----
L
S
W
K
E
G
A
A
A
C
V
V
L
A
A
---
P
G
Y
P
E
S
P
R
K
-----
G
--
I
P
---
L
------
H
----
V
P
EP-
P
----
E
G
V
L
V
F
-----
H
A
G
T
-
R
R
E
G
-
G
R
L
V
S
A
G
G
R
V
L
N
V
V
G
L
G
R
D
L
K
E
A
L
E
R
A
Y
A
Y
I
P
Q
V
-
G
F
P
G
A
V
Y
R
R
D
I
G
R
R
A
L
A
14
PsiBlast_PDB
72.55
34%
-73
- C1 -
1VKZ
-
PUR2_THEMA
A:
[16-410]
V
R
V
H
I
L
G
S
G
G
-
R
-
E
H
-
A
I
-
G
-
W
A
F
--
A
K
Q
-
G
Y
E
V
H
F
Y
P
G
N
A
G
T
-
K
-
R
-
D
-
G
T
-
N
H
P
----
Y
E
G
E
K
T
L
K
A
I
P
E
E
D
I
--
V
I
P
G
S
E
E
F
L
V
E
------
R
S
---
N
V
F
G
P
V
K
E
V
A
R
L
E
G
S
K
V
Y
A
K
R
F
M
K
K
Y
G
I
R
T
A
R
F
E
V
A
E
T
P
E
E
L
R
E
K
I
K
K
F
S
P
P
-
Y
V
I
K
A
D
G
L
A
R
G
K
G
V
L
I
L
D
S
K
E
E
T
I
E
K
G
S
K
L
I
I
G
E
L
I
K
G
V
K
G
P
V
V
I
D
E
F
L
A
G
N
E
L
S
A
M
A
V
V
N
G
R
N
F
V
I
L
P
F
V
R
D
Y
K
R
L
M
D
G
D
R
G
P
N
T
G
G
M
G
S
W
G
-
P
V
-
E
I
P
S
-
D
T
I
K
K
--
I
E
E
-----
L
-
F
D
K
T
L
W
G
V
E
K
E
G
Y
A
Y
R
G
F
L
Y
L
G
L
M
L
H
D
-
G
D
-
P
Y
I
L
E
Y
N
V
R
L
G
D
P
E
T
E
V
I
V
T
L
N
P
E
G
F
V
N
A
V
L
E
G
Y
---
R
G
GK
M
--
E
P
V
----------
E
P
R
G
F
A
V
D
V
V
L
A
A
---
R
G
Y
P
D
A
P
E
K
-----
G
K
E
I
T
---
L
---
P
--
E
----
E
G
-----------
L
I
F
-----
F
A
G
V
--
A
E
K
D
G
K
L
V
T
N
G
G
R
V
L
H
C
M
G
T
G
E
T
K
E
E
A
R
R
K
A
Y
E
L
A
E
K
V
-
H
F
E
G
K
T
Y
R
R
D
I
A
-----