@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0053: (2015-11-28 )
MTEKTKAVETTDVALAIDTLVQNGLKALDEMRQLNQEQVDYIVAKASVAALDAHGELALHAVEETGRGVFEDKATKNLFACEHVVNNMRHTKTVGVIEEDDVTGLTLIAEPVGVVCGITPTTNPTSTAIFKSLISLKTRNPIIFAFHPSAQESSAHAARIVRDAAIAAGAPENCVQWIEQPSIDATNALMNHDGIATILATGGNAMVKAAYSCGKPALGVGAGNVPAYVEKSANIRQAAHDIVMSKSFDNGMVCASEQAVIIDKEIYKEFVEEFKSYHTYFVNKKEKALLEEFCFGAKANSKNCAGAKLNPNIVGKSAVWIAEQAGFTVPEGTNILAAECTEVSEKEPLTREKLSPVIAVLKAESTEDGVEKARQMVEFNGLGHSAAIHTKDADLAREFGTRIRAIRVIWNSPSTFGGIGDVYNAFLPSLTLGCGSYGRNSVGDNVSAINLLNIKKVGRRRNNMQWFKVPSKTYFERDSIQYLQKCRDVERVMIVTDHAMVELGFLDRIIEQLDLRRNKVVYQIFAEVEPDPDITTVMKGTDLMRTFKPDTIIALGGGSPMDAAKVMWLFYEQPEVDFHDLVQKFMDIRKRAFKFPELGKKTKFVAIPTTSGTGSEVTPFAVISDKANNRKYPIADYSLTPTVAIVDPALVMTVPGFIAADTGMDVLTHATEAYVSQMANDYTDGLALQAIKIVFDYLERSVKDADFEAREKMHNASTMAGMAFANAFLGISHSMAHKIGAQFHTVHGRTNAILLPYVIRYNGTRPAKTATWPKYNYYRADEKYQDIAKLLGLPAATPEEAVESYAKAVYDLGTRLGIKMNFRDQGIDEKEWKEKSRELAFLAYEDQCSPANPRLPMVDHMQEIIEDAYYGYEERPGRRK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280-------------.-----------------------.......290.......300.......310.......320.......330.......-340.......350.......360.......370.......380.......390--.---.......400.......410.......420.....-..430..-.....440.......450.......460.......470.......480.-.---...---.---.--490.......500........510.......520.......530.......540.......550.......560.......570....-...580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.-....-..710.......720.......730.......740.......750.......760.......770.......780.......790--..--.--.--...800.......810.......820.......830.......840.......850.......860.......870.......880
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTEKTKAVET
T
D
V
A
L
A
I
D
T
L
V
Q
N
G
L
K
A
L
D
E
M
R
Q
L
N
Q
E
Q
V
D
Y
I
V
AK
A
S
V
A
A
LDAHG
E
L
A
L
H
A
V
E
E
TGRGVFEDKAT
K
N
L
F
A
C
E
H
V
V
N
NMRHT
K
T
VGVIEEDDVT
G
L
T
L
IAEPV
G
V
V
CGITPTTNP
T
S
T
A
I
F
K
S
L
I
SLKTRN
P
I
I
F
A
FHPSAQESS
A
H
A
A
R
I
V
R
D
A
AIAAGA
P
E
N
C
V
Q
W
I
EQPSID
A
T
N
A
L
MNHDG
I
A
T
I
L
ATGG
N
A
M
V
K
A
A
YSCGKPALGVGAGNV
P
A
Y
V
E
KSA
N
I
R
Q
A
A
H
D
I
V
MSKSFDNG
M
V
CASE
Q
A
V
I
I
D
K
E
I
Y
K
E
F
V
E
E
F
K
S
Y
H
T
Y
F--------------V-----------------------
N
K
K
E
K
A
L
L
E
E
F
CFGAKANSKNCAGAKLNPNIVGK
S
A
V
W
I
A
EQAGFTVPEGT
N
I
L
A
AE-CTEVSEKEPL
T
R
E
K
L
S
P
V
I
A
V
LKAEST
E
D
G
V
E
K
A
R
Q
M
V
E
FNGLGHS
A
A
IHT
K
---
D
---
A
D
L
A
R
E
F
G
TR
I
R
A
I
R
V
I
WNSPSTFG
G
I
G
D
V
Y
N
A
F
L
-
P
S
L
TLGC-GSYGRNSVGDNV
S
A
I
N
L
L
N
I
K
K
V
G
RRRNN
M
Q
W
F
KVP
S
K
TYFE
R
D
S
I
Q
Y
L
-
Q
---
K
C
R---D---V--
E
R
V
M
I
V
TD
H
A
M
-
V
E
L
G
F
L
D
R
I
I
E
Q
L
DLRRN
K
V
V
Y
Q
I
F
AEVEPDPD
I
T
T
V
MKGT
D
L
M
RTFKP
D
T
I
I
A
LGGGSPM
D
A
A
K
V
M
W
L
F
YEQPEV-
D
F
H
D
L
V
Q
K
F
M
D
I
R
K
R
A
FKFPELGKK
T
K
F
V
A
I
PTTSGTGSE
V
T
P
F
A
V
I
SDKANNRKYPIADYSLT
P
T
V
A
I
VDP
A
L
V
M
TVP
G
F
IAADT
G
M
D
V
L
T
H
A
T
E
A
Y
V
S
Q
M
A
N
DYTD
G
L
A
L
Q
A
I
K
I
V
F
D
Y
L
E
R
S
VK-DA
D
F
-
E
A
R
E
K
MHN
A
S
T
M
A
G
M
A
F
A
N
A
F
L
G
I
S
H
S
M
A
H
K
IG
A
Q
F
H
T
VHGRT
N
A
I
L
L
P
Y
V
I
R
YNGTRPAKTATWPKYNYYRA
D
E
K
Y
Q
D
I
A
K
L
LG--LP--A--A--
T
P
E
E
A
V
E
S
Y
A
K
A
V
Y
D
L
GTRL
G
I
K
M
NFRDQGI
D
E
K
E
W
K
E
K
SR
E
L
A
F
L
A
YEDQCSPANPRL
P
M
V
D
H
M
Q
E
I
I
E
D
A
YYGYEERPGRRK
1
PsiBlast_PDB
88.32
48%
-72
- C2 -
3MY7
1
?
A:
[9-449]
----------------
L
D
A
M
I
A
R
V
K
K
A
Q
E
E
F
A
T
Y
S
Q
E
Q
V
D
K
I
F
R
A
A
S
L
A
A
N
Q
A
R
I
P
L
A
Q
Q
A
V
E
E
S
G
M
G
I
V
E
D
K
V
I
K
N
H
F
A
S
E
F
I
Y
N
K
Y
K
D
E
Q
T
C
G
I
L
-------
T
M
T
I
A
E
P
V
G
I
I
C
G
I
V
P
T
T
N
P
T
S
T
A
I
F
K
S
L
I
S
L
K
T
R
N
G
I
I
F
S
P
H
P
R
A
K
N
S
T
N
D
A
A
K
L
V
L
D
A
A
V
A
A
G
A
P
K
D
I
I
G
W
I
D
Q
P
S
V
E
L
S
N
A
L
M
K
H
D
D
I
A
L
I
L
A
T
G
G
P
G
M
V
K
A
A
Y
S
S
G
K
P
A
I
G
V
G
--
N
V
P
V
V
I
D
E
T
A
D
I
K
R
A
V
A
S
V
L
M
S
K
T
F
D
N
G
V
V
C
A
S
E
Q
A
V
I
V
V
D
E
V
Y
D
E
V
K
E
R
F
A
S
H
K
A
H
V
--------------
L
-----------------------
S
K
T
D
A
D
K
V
R
K
V
L
L
--------
I
D
G
A
-
L
N
A
K
I
V
G
Q
P
A
T
A
I
A
E
M
A
G
V
K
V
P
A
D
T
K
V
L
I
G
E
G
L
G
K
V
S
Y
D
D
A
F
A
H
E
K
L
S
P
T
L
G
M
F
R
A
D
N
F
E
D
A
V
A
Q
A
V
T
M
V
E
I
G
G
I
G
H
T
S
G
L
Y
T
N
QDV
N
---
A
D
R
I
R
Y
F
G
D
K
M
K
T
A
R
I
L
I
N
I
P
T
T
-----------------------------
S
E
N
V
G
P
K
H
L
I
N
K
K
T
V
A
K
R
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Fugue
87.54
40%
-69
- C2 -
3K9D
1
?
A:
[3-456]
-----
L
E
D
K
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
F
--------------
L
-----------------------
S
D
A
E
A
V
Q
L
G
K
F
I
L
R
P
N
G
S
--------
M
N
P
A
I
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
-
E
T
K
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
---
D
---
K
E
I
I
R
E
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.98
41%
-72
- C2 -
3K9D
2
?
C:
[14-445]
----------------
V
R
N
L
I
E
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
F
--------------
L
-----------------------
S
D
A
E
A
V
Q
L
G
K
F
I
L
R
P
N
G
S
--------
M
N
P
A
I
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
-
E
T
K
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
---
D
---
K
E
I
I
R
E
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
85.90
41%
-71
- C2 -
3K9D
1
?
A:
[14-445]
----------------
V
R
N
L
I
E
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
F
--------------
L
-----------------------
S
D
A
E
A
V
Q
L
G
K
F
I
L
R
P
N
G
S
--------
M
N
P
A
I
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
-
E
T
K
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
---
D
---
K
E
I
I
R
E
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
85.73
41%
-71
- C2 -
3K9D
1
?
B:
[14-445]
----------------
V
R
N
L
I
E
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
F
--------------
L
-----------------------
S
D
A
E
A
V
Q
L
G
K
F
I
L
R
P
N
G
S
--------
M
N
P
A
I
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
A
R
V
L
I
A
E
-
E
T
K
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
---
D
---
K
E
I
I
R
E
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
-
L
V
-
P
A
L
T
L
G
C
-
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
81.39
49%
-58
- C2 -
3MY7
1
?
A:
[2-449]
---------
P
V
T
N
M
A
E
L
D
A
M
I
A
R
V
K
K
A
Q
E
E
F
A
T
Y
S
Q
E
Q
V
D
K
I
F
R
A
A
S
L
A
A
N
Q
A
R
I
P
L
A
Q
Q
A
V
E
E
S
G
M
G
I
V
E
D
K
V
I
K
N
H
F
A
S
E
F
I
Y
N
K
Y
K
D
E
Q
T
C
G
I
L
-------
T
M
T
I
A
E
P
V
G
I
I
C
G
I
V
P
T
T
N
P
T
S
T
A
I
F
K
S
L
I
S
L
K
T
R
N
G
I
I
F
S
P
H
P
R
A
K
N
S
T
N
D
A
A
K
L
V
L
D
A
A
V
A
A
G
A
P
K
D
I
I
G
W
I
D
Q
P
S
V
E
L
S
N
A
L
M
K
H
D
D
I
A
L
I
L
A
T
G
G
P
G
M
V
K
A
A
Y
S
S
G
K
P
A
I
G
V
G
--
N
V
P
V
V
I
D
E
T
A
D
I
K
R
A
V
A
S
V
L
M
S
K
T
F
D
N
G
V
V
C
A
S
E
Q
A
V
I
V
V
D
E
V
Y
D
E
V
K
E
R
F
A
S
H
K
A
H
V
L
S
K
T
D
A
D
K
V
R
K
V
L
L
I
-----------------------
D
G
A
L
N
A
K
I
V
G
Q
P
A
T
A
I
A
E
M
-----
A
-------
G
V
---
K
V
P
A
D
T
K
V
L
I
G
E
G
--------
L
G
K
V
S
Y
D
D
A
F
A
H
E
K
L
S
P
T
L
G
M
F
R
A
D
N
F
E
D
A
V
A
Q
A
V
T
M
V
E
I
G
G
I
G
H
T
S
G
L
Y
T
N
---
Q
DVN
A
D
R
I
R
Y
F
G
D
K
M
K
T
A
R
I
L
I
N
I
P
T
T
-----------------------------
S
E
N
V
G
P
K
H
L
I
N
K
K
T
V
A
K
R
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
HHSearch
79.09
35%
-71
- C1 -
1RRM
4
FUCO_ECOLI
A:
[4-386]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
-
T
---
D
E
V
---
K
R
R
G
Y
--
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
--
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
------
L
----
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
-
G
-
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
--------------
F
T
G
E
K
Y
R
D
I
A
R
V
M
G
--
V
K
--
V
EG
M
--
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
K
E
D
----
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
E
G
G
--------
3
PsiBlast_PDB
77.54
34%
-80
- C1 -
2BI4
3
FUCO_ECOLI
A:
[22-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
G
R
G
A
V
G
A
L
-
T
D
E
V
K
R
R
---
G
---
Y
--
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
--
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
--
G
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
--------------
E
K
Y
R
D
I
A
R
V
M
G
--
V
K
VE
G
--
M
--
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
----
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
-----------
69
HHSearch
76.75
36%
-58
- C2 -
3K9D
1
?
A:
[3-452]
-----
L
E
D
K
D
L
R
S
I
Q
E
V
R
N
L
I
E
S
A
N
K
A
Q
K
E
L
A
A
M
S
Q
Q
Q
I
D
T
I
V
K
A
I
A
D
A
G
Y
G
A
R
E
K
L
A
K
M
A
H
E
E
T
G
F
G
I
W
Q
D
K
V
I
K
N
V
F
A
S
K
H
V
Y
N
Y
I
K
D
M
K
T
I
G
M
L
K
E
D
N
E
K
K
V
M
E
V
A
V
P
L
G
V
V
A
G
L
I
P
S
T
N
P
T
S
T
V
I
Y
K
T
L
I
S
I
K
A
G
N
S
I
V
F
S
P
H
P
N
A
L
K
A
I
L
E
T
V
R
I
I
S
E
A
A
E
K
A
G
C
P
K
G
A
I
S
C
M
T
V
P
T
I
Q
G
T
D
Q
L
M
K
H
K
D
T
A
V
I
L
A
T
G
G
S
A
M
V
K
A
A
Y
S
S
G
T
P
A
I
G
V
G
P
G
N
G
P
A
F
I
E
R
S
A
N
I
P
R
A
V
K
H
I
L
D
S
K
T
F
D
N
G
T
I
C
A
S
E
Q
S
V
V
V
E
R
V
N
K
E
A
V
I
A
E
F
R
K
Q
G
A
H
F
--------------
L
S
D
A
E
A
V
Q
L
G
K
F
I
L
RPNGSMNPAI
V
G
K
S
V
Q
H
I
A
N
L
A
G
L
T
V
P
A
D
-----
A
R
V
---
L
I
A
E
------------------------
E
T
K
V
G
A
K
I
P
Y
S
R
E
K
L
A
P
I
L
A
F
Y
T
A
E
T
W
Q
E
A
C
E
L
S
M
D
I
L
Y
H
E
G
A
G
H
T
L
I
I
H
S
E
---
D
---
K
E
I
I
R
E
F
A
L
K
K
P
V
S
R
L
L
V
N
T
P
G
A
L
G
G
I
G
A
T
T
N
L
V
P
A
L
T
L
G
C
G
A
V
G
G
S
S
S
S
D
N
I
G
P
E
N
L
F
N
I
R
R
I
A
T
G
V
L
E
L
E
D
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
76.53
34%
-77
- C1 -
2BL4
3
FUCO_ECOLI
A:
[22-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
G
R
G
A
V
G
A
L
-
T
D
E
V
K
R
R
---
G
---
Y
--
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
--
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
--
G
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
--------------
E
K
Y
R
D
I
A
R
V
M
G
--
V
K
VE
G
--
M
--
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
----
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
-----------
24
PsiBlast_CBE
76.46
34%
-77
- C1 -
2BI4
2
FUCO_ECOLI
B:
[22-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
G
R
G
A
V
G
A
L
-
T
DEV
K
R
R
---
G
---
Y
--
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
--
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
--
G
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
--------------
E
K
Y
R
D
I
A
R
V
M
G
--
V
K
VE
G
--
M
--
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
----
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
-----------
5
PsiBlast_PDB
76.03
33%
-70
- C1 -
1RRM
4
FUCO_ECOLI
A:
[13-385]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
G
R
G
A
V
G
A
L
-
T
D
E
V
K
R
R
---
G
---
Y
--
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
A
A
--
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
--
G
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
--------------
E
K
Y
R
D
I
A
R
V
M
G
--
V
K
VE
G
--
M
--
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
----
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
E
G
G
--------
40
PsiBlast_CBE
74.62
33%
-81
- C1 -
3BFJ
1
DHAT_KLEPN
E:
[8-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
---
R
C
Q
---
L
---
L
GG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
--
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
-
E
G
-
D
L
Y
----
Q
Y
A
G
I
E
T
L
T
N
P
L
P
P
I
------
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
-
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
--------------
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
--
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
----
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-----------
23
PsiBlast_CBE
74.41
34%
-76
- C1 -
2BL4
2
FUCO_ECOLI
B:
[22-392]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
G
R
G
A
V
G
A
L
-
T
DEV
K
R
R
---
G
---
Y
--
Q
K
A
L
I
V
T
D
K
T
L
-
V
Q
C
G
V
V
A
K
V
T
D
K
M
D
--
A
A
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
----------
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
--
G
D
K
-
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
--------------
E
K
Y
R
D
I
A
R
V
M
G
--
V
K
VE
G
--
M
--
S
L
E
E
A
R
N
A
A
V
E
A
V
F
A
L
N
R
D
V
G
I
P
P
H
L
R
D
V
G
V
R
----
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
-----------
41
PsiBlast_CBE
73.88
33%
-80
- C1 -
3BFJ
1
DHAT_KLEPN
D:
[8-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
---
R
C
Q
---
L
---
L
GG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
--
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
-
E
G
-
D
L
Y
----
Q
Y
A
G
I
E
T
L
T
N
P
L
P
P
I
------
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
-
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
--------------
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
--
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
----
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-----------
43
PsiBlast_CBE
73.73
33%
-77
- C1 -
3BFJ
1
DHAT_KLEPN
B:
[8-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
---
R
C
Q
---
L
---
L
GG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
--
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
-
E
G
-
D
L
Y
----
Q
Y
A
G
I
E
T
L
T
N
P
L
P
P
I
------
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
-
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
--------------
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
--
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
----
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-----------
42
PsiBlast_CBE
73.26
33%
-81
- C1 -
3BFJ
1
DHAT_KLEPN
C:
[8-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
---
R
C
Q
---
L
---
L
GG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
--
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
-
E
G
-
D
L
Y
----
Q
Y
A
G
I
E
T
L
T
N
P
L
P
P
I
------
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
-
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
--------------
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
--
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
----
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-----------
39
PsiBlast_CBE
72.61
33%
-80
- C1 -
3BFJ
1
DHAT_KLEPN
F:
[8-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
---
R
C
Q
---
L
---
L
GG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
--
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
-
E
G
-
D
L
Y
----
Q
Y
A
G
I
E
T
L
T
N
P
L
P
P
I
------
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
-
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
--------------
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
--
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
----
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-----------
68
HHSearch
72.32
33%
-70
* C1 *
3OX4
2
ADH2_ZYMMO
A:
[4-383]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
-
I
---
K
D
L
NGS
G
---
F
--
K
N
A
L
I
V
S
D
A
F
M
-
N
K
S
G
V
V
K
Q
V
A
D
L
L
K
A
Q
--
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
G
E
--
V
K
D
Y
E
G
I
----------
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
-
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
--------------
V
V
A
G
R
L
K
D
V
G
V
A
M
G
--
L
D
--
I
--
A
NL
G
D
K
E
G
A
E
A
T
I
Q
A
V
R
D
L
A
A
S
I
G
I
P
A
N
L
T
E
L
G
A
K
K
E
D
----
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
-----------
6
PsiBlast_PDB
71.59
33%
-79
- C1 -
3BFJ
1
DHAT_KLEPN
A:
[8-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
---
R
C
Q
---
L
---
L
GG
K
K
A
L
L
V
T
D
K
G
L
R-
K
D
G
A
V
D
K
T
L
H
Y
L
--
R
E
A
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
-
E
G
-
D
L
Y
----
Q
Y
A
G
I
E
T
L
T
N
P
L
P
P
I
------
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
-
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
--------------
Y
N
L
I
A
N
P
E
K
F
A
D
I
A
E
L
M
G
EN
I
T
--
G
--
L
--
S
T
L
D
A
A
E
K
A
I
A
A
I
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
V
K
E
T
D
F
P
----
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
-----------