@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0094: (2015-11-28 )
MITQRQNDILNLIVELFTQTHEPVGSKALQRTIESSSATIRNDMAKLEKLGLLEKAHTSSGRMPSPAGFKYFVEHSLRLDSIDEQDIYHVIKAFDFEAFKLEDMLQKASHILSEMTGYTSVILDVEPARQRLTGFDVVQLSNHDALAVMTLDESKPVTVQFAIPRNFLTRDLIAFKAIVEERLLDGSVMDIHYKLRTEIPQIVQKYFVTTDNVLQLFDYVFSELFLETVFVAGKVNSLTYSDLSTYQFLDNEQQVAISLRQGLKEGEMASVQVADSQEAALADVSVLTHKFLIPYRGFGLLSLIGPIDMDYRRSVSLVNIIGKVLAAKLGDYYRYLNSNHYEVH
Atome Classification :
(20 SA)
-------.........10........--20.------.......30--.--..-.....40........50....--....60........---70-........80....--....90---------------...--..-....100..-----------------.....110.......120.---......130...--....140-------........150.......-160.......170.......180--------....---.....190.......200.......-210.......220---.......230........240-------------.......250...-...-.260.......270.......280.......290...--------.--...300.......--------------310..-.....320----......---------..330.......340..------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------MIT
Q
R
Q
N
D
I
L
N
L
I
V
E
L
F
T
Q--THE------PV
G
S
K
A
L
Q
R
--
T
--
I
E
-SSS
A
T
I
R
N
D
M
A
K
L
E
K
LG
L
L
E
K--AHTSSGRMPSP
A
G
F
---
K
Y
-
F
V
E
HSLRLDSI
D
E
Q
--
D
I
Y
H
V
----------------
I
K
A
--FD-F
E
A
F
K
L
E
D
M
-----------------
L
Q
K
A
S
H
I
L
S
E
MTGY
T
S
V
I
L
---DVE
P
A
R
Q
RLTG
F
--
D
V
V
Q
LS--------NH
D
A
L
A
V
M
T
LDESK
P
V
T
V
-
Q
F
AI
P
R
N
F
L
T
R
D
L
I
A
F
K
A
I
V
E
----------
E
RLL---DG
S
V
M
D
I
H
Y
K
L
R
T
E
I
P
Q
I
V
Q
K
Y
FVT-
T
D
N
V
L
Q
L
F
D
Y
V
F
S
---
E
L
F
L
E
T
V
F
V-AGKVN
S
L
TYSD-------------L
S
T
Y
Q
FLDN
E
Q
Q
V
-
A
I
S
-
L
R
QGLKEGE
M
A
S
V
Q
VADSQE
A
A
L
A
D
V
S
V
L
T
H
K
FLIPY--------R--G
F
G
L
L
S
L
IGPI
D
M
--------------
D
Y
R
RS-
V
S
L
V
N
I
I
-----
G
K
V
L
A
A
---------
K
L
G
D
Y
Y
R
Y
LNSNHYEVH------------------------------------------
42
Fugue
88.28
19%
-92
- C3 -
1STZ
-
HRCA_THEMA
A:
[14-336]
-------
K
L
N
D
R
Q
R
K
V
L
Y
C
I
V
R
E
Y
I
E
--
N
K
K
------
P
V
S
S
Q
R
V
L
E
V
S
N
--
I
E
-
F
S
S
A
T
I
R
N
D
M
K
K
L
E
Y
L
G
Y
I
Y
Q
--
P
H
T
S
A
G
R
I
P
T
D
K
G
L
---
R
F
-
Y
Y
E
E
M
L
K
I
S
K
E
T
S
E
--
A
D
L
A
V
----------------
E
T
F
--
K
S
-
M
P
L
A
D
P
E
K
V
-----------------
L
F
L
A
G
N
L
L
A
R
L
T
E
G
Y
V
L
I
E
---
R
P
N
T
R
D
L
K
I
L
R
V
--
M
L
I
P
V
S
--------
E
D
Y
L
I
F
S
I
L
T
E
F
G
V
S
K
V
T
-
P
I
K
T
Q
E
R
---
L
N
W
E
E
I
E
R
Q
L
N
----------
F
L
L
R
---
G
R
T
V
G
E
V
L
M
G
K
I
E
S
L
K
G
----------
S
G
F
L
R
L
I
E
S
L
I
G
---
E
T
V
E
R
Y
L
D
A
G
L
E
N
L
L
K
D
E
T
L
T
-------------
L
E
D
I
R
N
L
L
E
E
V
K
D
-
Q
K
F
-
L
E
S
L
V
G
E
G
I
T
V
R
I
G
-
R
E
I
G
R
K
K
L
E
K
F
A
V
F
S
G
K
Y
F
K
G
E
--------
S
--
P
I
G
S
V
Y
L
F
T
S
K
V
T
--------------
K
Y
D
R
N
-
H
R
V
F
E
Y
I
-----
L
N
R
L
S
E
---------
Y
F
T
S
T
S
-----------------------------------------------------
21
HHSearch
87.18
18%
-91
- C3 -
1STZ
-
HRCA_THEMA
A:
[14-336]
-------
K
L
N
D
R
Q
R
K
V
L
Y
C
I
V
R
E
Y
I
E
--
N
K
K
------
P
V
S
S
Q
R
V
L
E
--
V
S
N
I
E
-
F
S
S
A
T
I
R
N
D
M
K
K
L
E
Y
L
G
Y
I
Y
Q
--
P
H
T
S
A
G
R
I
P
T
D
K
G
L
---
R
F
-
Y
Y
E
E
M
L
K
I
S
K
E
T
S
E
---
A
D
L
A
----------------
V
E
T
--
F
K
S
M
P
L
A
D
P
E
K
V
-----------------
L
F
L
A
G
N
L
L
A
R
L
T
E
G
Y
V
L
I
E
---
R
P
N
T
R
D
L
K
I
L
R
V
--
M
L
I
P
V
S
--------
E
D
Y
L
I
F
S
I
L
T
E
F
G
V
S
K
V
T
-
P
I
K
T
Q
E
R
L
---
N
W
E
E
I
E
R
Q
L
N
----------
F
L
L
R
---
G
R
T
V
G
E
V
L
M
G
K
I
E
S
L
K
G
--
S
G
F
L
R
L
-
I
E
S
L
I
G
E
T
V
E
R
Y
L
---
D
A
G
L
E
N
L
L
K
-
D
E
T
L
T
L
E
D
I
R
N
-------------
L
L
---
E
E
V
K
D
Q
K
F
L
E
S
L
-
V
----
G
E
G
I
T
V
R
I
G
R
E
I
G
-
R
K
K
L
E
K
F
A
V
F
S
G
K
Y
F
K
G
E
--------
S
--
P
I
G
S
V
Y
L
F
T
S
K
V
T
--------------
K
Y
D
R
N
-
H
R
V
F
E
Y
I
-----
L
N
R
L
S
E
---------
Y
F
T
S
T
S
-----------------------------------------------------
46
Fugue
65.84
16%
-73
* C4 *
1O57
6
PURR_BACSU
A:
[2-276]
--------
K
F
R
R
S
G
R
L
V
D
L
T
N
Y
L
L
T
H
--
P
H
E
------
L
I
P
L
T
F
F
S
E
--
R
--
Y
E
-
S
A
K
S
S
I
S
E
D
L
T
I
I
K
Q
T
F
E
Q
Q
G
--
I
G
T
L
L
T
V
P
G
A
A
G
G
V
---
K
Y
-
I
P
K
M
K
--------------------------------
Q
A
E
--
A
E
-
E
F
V
Q
T
L
G
Q
S
-----------------
L
A
N
P
E
R
I
L
P
G
G
Y
V
Y
L
T
D
I
L
---
G
K
P
S
V
L
S
K
V
G
K
L
--
F
A
S
V
F
A
--------
E
R
E
I
D
V
V
M
T
V
-
A
T
K
G
I
P
L
-
A
Y
A
A
A
S
Y
L
N
V
----
P
V
V
I
V
R
K
----------
D
G
S
T
---
V
S
I
N
Y
V
S
G
S
S
N
R
I
Q
T
M
S
L
A
K
R
S
M
K
T
-
G
S
N
V
L
I
I
D
D
F
M
--------------------------------------------------------------------------
K
A
G
G
T
I
N
G
M
I
N
L
L
D
E
F
N
A
N
V
--------
A
--
G
I
G
V
L
V
E
A
E
G
V
D
E
--------------
R
L
V
D
E
Y
M
S
L
L
T
L
S
TINMK
E
K
S
I
E
I
---------
Q
N
G
N
F
L
R
F
F
K
D
N
-----------------------------------------------
1
PsiBlast_PDB
60.65
41%
-83
- C3 -
1STZ
-
HRCA_THEMA
A:
[15-94]
--------
L
N
D
R
Q
R
K
V
L
Y
C
I
V
R
E
Y
I
E
--
N
K
K
------
P
V
S
S
Q
R
V
L
E
V
S
N
--
I
E
-
F
S
S
A
T
I
R
N
D
M
K
K
L
E
Y
L
G
Y
I
Y
Q
--
P
H
T
S
A
G
R
I
P
T
D
K
G
L
---
R
F
-
Y
Y
E
E
M
L
K
I
S
K
E
T
S
E
--
A
D
L
A
V
----------------
E
T
F
--
K
S
-
M
P
L
A
D
P
E
K
V
-----------------
L
F
L
A
G
N
L
L
A
R
L
T
E
G
Y
V
L
I
E
---
R
P
N
T
R
D
L
K
I
L
R
V
--
M
L
I
P
V
S
--------
E
D
Y
L
I
F
S
I
L
T
E
F
G
V
S
K
V
T
-
P
I
K
T
Q
E
R
L
N
W
E
E
I
E
R
Q
L
N
F
L
L
----------
R
G
R
T
---
V
G
E
V
L
M
G
K
I
E
S
L
K
G
S
G
F
L
R
L
I
E
S
L
I
-
G
E
T
V
E
R
Y
L
D
A
G
L
E
---
N
L
L
K
D
E
T
L
T
-
L
E
D
I
R
N
L
L
E
E
V
-------------
K
D
Q
K
F
L
E
S
L
V
G
E
G
-
I
T
V
-
R
I
G
R
E
I
G
R
K
K
L
E
K
F
A
V
F
S
G
K
Y
F
K
G
E
S
P
I
G
S
V
Y
L
F
T
S
K
--------
V
--
T
K
Y
D
R
N
H
R
V
F
E
Y
I
--------------
L
N
R
L
S
-
E
Y
F
T
S
T
S
-------------------------------------------------------------------------------
3
PsiBlast_PDB
60.01
27%
-70
- C3 -
3AU5
-
MYO10_HUMAN
A:
[1927-2048]
---------------------------------------------------------------------------------------------------------------------------------------
K
W
--
R
K
-
F
Q
G
M
N
Q
E
Q
A
-----------------
M
A
K
Y
M
A
L
I
K
E
W
P
G
Y
G
S
T
L
F
---
D
V
E
C
---
K
E
G
G
F
PQ
E
L
W
L
G
V
--------
S
A
D
A
V
S
V
Y
K
R
G
E
G
R
P
L
E
V
F
Q
Y
E
H
I
L
S
F
G
A
P
L
A
N
T
Y
K
I
V
V
D
----------
E
R
E
L
L
F
E
T
S
E
V
V
D
V
A
K
L
M
K
A
Y
I
S
M
I
V
K
K
R
Y
S
T
-
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
52.29
14%
-61
- C2 -
2HCN
3
A:
[12-582]
-----------
L
V
N
G
V
V
R
L
L
S
K
P
W
D
T
IT
T
K
A
------
P
E
P
P
E
G
V
K
Y
--
V
--
L
N
-
E
T
T
N
W
L
W
A
F
L
A
R
E
K
R
P
R
M
C
S
R
--
E
E
F
I
R
K
V
N
S
N
A
A
Q
W
R
S
A
R
E
-
A
V
E
D
P
K
F
W
E
M
V
D
E
E
--
R
E
A
H
L
RGECHTCRA
I
W
F
M
W
L
G
A
R
F
--
L
E
-
F
E
A
L
G
F
L
N
E
DHWLGRKNSGGGVEGLG
L
Q
K
L
G
Y
I
L
R
E
V
G
T
R
P
G
G
R
I
Y
A
D
D
T
A
G
W
D
T
R
I
T
R
A
--
D
L
E
N
E
A
K
V
L
E
L
L
DG
E
H
R
R
L
A
R
A
I
I
E
L
T
Y
R
S
G
Q
-
V
V
T
Y
A
L
N
T
F
T
N
L
A
V
Q
L
V
R
M
M
E
G
E
GVIGPDDV
E
K
L
T
---
K
G
K
G
P
K
V
R
T
W
L
S
E
N
G
E
E
R
L
S
R
M
A
V
S
G
D
D
C
V
V
K
P
L
D
D
R
F
A
TSL
H
F
L
N
A
M
S
K
V
-
R
K
D
I
Q
E
W
K
P
S
T
G
W
YDWQQVPFCS
N
H
F
T
E
L
I
M
K
D
G
R
T
L
-
V
T
P
-
C
R
G
--
Q
D
E
L
V
G
R
A
R
I
S
P
N
V
R
D
T
A
C
L
A
K
S
Y
A
Q
M
W
L
L
L
Y
FHR
R
D
L
R
L
M
--
A
N
A
I
C
S
A
V
-
P
V
N
W
VPTGRTTWSIHAGG
E
W
M
T
T
-
E
D
M
L
E
V
W
-----
N
R
V
W
I
E
ENEWMEDKT
P
V
E
K
W
S
D
V
P
Y
S
G
K
R
E
D
I
W
C
GSLIGT
R
A
R
A
T
W
A
E
N
I
Q
V
A
I
N
Q
V
R
S
I
I
G
D
E
K
Y
V
D
YMSSLK
48
Fugue
51.82
15%
-53
- C4 -
3BM3
2
?
A:
[2-260]
---------------
V
R
N
L
V
I
D
I
-----------------
T
K
K
P
T
Q
--
N
--
I
P
-
P
T
N
E
I
I
E
E
A
I
T
E
L
N
V
D
E
L
L
D
R
LF
E
K
D
E
S
G
E
V
I
T
P
S
R
I
---
A
K
M
L
E
E
K
A
F
E
I
Y
K
E
Y
E
K
--
Q
V
R
E
A
----------------
Y
L
S
A
G
Y
S
-
R
E
K
L
E
Q
S
F
Q
-----------------
Q
A
R
F
S
R
G
G
K
A
F
E
I
I
F
T
K
L
L
---
N
K
F
G
I
R
-------------
Y
--------
E
H
D
R
V
I
K
I
Y
D
Y
I
T
E
G
E
K
P
-
A
F
I
I
P
S
V
R
T
F
L
N
D
P
S
S
A
I
L
I
T
----------
V
K
------
R
K
V
R
E
R
W
R
E
A
V
G
E
A
Q
I
L
R
N
K
F
G
D
E
-----
I
N
F
W
F
V
G
F
D
---
E
E
F
----------------------------------------
T
I
Y
S
-
A
I
A
M
L
D
N
G
I
D
-----
R
V
Y
V
I
D
G
R
Y
D
S
L
I
E
E
I
K
---
R
I
S
D
P
--------------------
N
F
N
E
D
--------------
K
Y
I
Q
K
-
I
R
R
F
S
D
I
-----
F
D
D
I
I
Q
---------
F
L
N
K
H
------------------------------------------------------
2
PsiBlast_PDB
50.68
27%
-69
- C3 -
3AU4
-
MYO10_HUMAN
A:
[1927-2046]
---------------------------------------------------------------------------------------------------------------------------------------
K
W
--
R
K
-
F
Q
G
M
N
Q
E
Q
A
-----------------
M
A
K
Y
M
A
L
I
K
E
W
P
G
Y
G
S
T
L
F
---
D
V
E
C
---
K
E
G
G
F
PQ
E
L
W
L
G
V
--------
S
A
D
A
V
S
V
Y
K
R
G
E
G
R
P
L
E
V
F
Q
Y
E
H
I
L
S
F
G
A
P
L
A
N
T
Y
K
I
V
V
D
----------
E
R
E
L
L
F
E
T
S
E
V
V
D
V
A
K
L
M
K
A
Y
I
S
M
I
V
K
K
R
Y
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
50.17
12%
-26
- C3 -
2LNB
-
ZBP1_HUMAN
A:
[17-66]
--------
E
G
H
L
E
Q
R
I
L
Q
V
L
T
----
E
--
A
G
S
------
P
V
K
L
A
Q
L
V
K
--
E
--
C
Q
-
A
P
K
R
E
L
N
Q
V
L
Y
R
M
K
K
E
L
K
V
S
L
--
T
S
P
A
T
W
C
L
G
G
T
D
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
49.41
25%
-22
* C3 *
2PN6
-
?
A:
[2-49]
---------
D
E
I
D
L
R
I
L
K
I
L
-----
Q
--
Y
N
A
------
K
Y
S
L
D
E
I
A
R
--
E
--
I
R
-
I
P
K
A
T
L
S
Y
R
I
K
K
L
E
K
D
G
V
I
K
G
--
Y
Y
A
Y
I
N
P
A
S
L
N
L
D
Y
---
I
V
-
I
T
S
V
K
A
K
Y
G
K
N
Y
H
V
--
E
L
G
N
K
----------------
L
A
Q
--
I
P
-
G
V
W
G
V
Y
F
V
L
-----------------
G
D
N
D
F
I
V
M
A
R
Y
K
T
R
E
E
F
M
E
---
K
F
L
E
R
V
M
S
I
P
E
V
--
E
R
T
S
T
Q
--------
V
V
V
K
I
I
K
E
S
P
N
I
V
I
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
49.29
26%
-68
- C3 -
3PZD
-
A:
[391-511]
---------------------------------------------------------------------------------------------------------------------------------------
K
W
--
R
K
-
F
Q
G
M
N
Q
E
Q
A
-----------------
M
A
K
Y
M
A
L
I
K
E
W
P
G
Y
G
S
T
L
F
---
D
V
E
C
---
K
---
F
PQ
E
L
W
L
G
V
--------
S
A
D
A
V
S
V
Y
K
R
G
E
G
R
P
L
E
V
F
Q
Y
E
H
I
L
S
F
G
A
P
L
A
N
T
Y
K
I
V
V
D
----------
E
R
E
L
L
F
E
T
S
E
V
V
D
V
A
K
L
M
K
A
Y
I
S
M
I
V
K
K
R
Y
S
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
46.29
16%
-31
- C3 -
2CYY
-
REG6_PYRHO
A:
[5-54]
--------
L
D
E
I
D
K
K
I
I
K
I
L
-----
Q
--
N
D
G
------
K
A
P
L
R
E
I
S
K
--
I
--
T
G
-
L
A
E
S
T
I
H
E
R
I
R
K
L
R
E
S
G
V
I
K
K
--
F
T
A
I
I
D
P
E
A
L
G
Y
S
M
---
L
A
-
F
I
L
V
K
V
K
A
G
K
Y
S
E
V
--
A
S
N
L
A
----------------
K
Y
P
--
E
I
-
V
E
V
Y
E
T
T
G
D
-----------------
Y
D
M
V
V
K
I
R
T
K
N
S
E
E
L
N
N
F
L
---
D
L
I
G
S
I
P
G
V
E
G
T
--
H
T
M
I
V
L
--------
K
T
H
K
E
T
T
E
L
P
I
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
46.27
20%
-25
- C3 -
2CG4
-
ASNC_ECOLI
A:
[6-55]
--------
I
D
N
L
D
R
G
I
L
E
A
L
-----
M
--
G
N
A
------
R
T
A
Y
A
E
L
A
K
--
Q
--
F
G
-
V
S
P
E
T
I
H
V
R
V
E
K
M
K
Q
A
G
I
I
T
G
--
A
R
I
D
V
S
P
K
Q
L
G
Y
D
V
---
G
C
-
F
I
G
I
I
L
K
S
A
K
D
Y
P
S
--
A
L
A
K
L
----------------
E
S
L
--
D
E
-
V
T
E
A
Y
Y
T
T
G
-----------------
H
Y
S
I
F
I
K
V
M
C
R
S
I
D
A
L
Q
H
V
---
L
I
N
K
I
Q
T
I
D
E
I
Q
--
S
T
E
T
L
I
--------
V
L
Q
N
P
I
M
R
T
I
K
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
46.10
16%
-51
- C3 -
2P5V
-
?
A:
[8-57]
--------
L
D
K
T
D
I
K
I
L
Q
V
L
-----
Q
--
E
N
G
------
R
L
T
N
V
E
L
S
E
--
R
--
V
A
-
L
S
P
S
P
C
L
R
R
L
K
Q
L
E
D
A
G
I
V
R
Q
--
Y
A
A
L
L
S
P
E
S
V
N
L
G
L
---
Q
A
-
F
I
R
V
S
I
R
K
A
K
D
A
R
E
--
D
F
A
A
S
----------------
V
R
K
--
W
P
-
E
V
L
S
C
F
A
L
T
-----------------
G
E
T
D
Y
L
L
Q
A
F
F
T
D
M
N
A
F
S
H
---
F
V
L
D
T
L
L
S
H
H
G
V
--
Q
D
A
Q
S
S
--------
F
V
L
K
E
I
K
H
T
T
S
L
P
L
N
H
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
45.85
13%
-21
- C1 -
4CGK
7
?
A:
[42-392]
SNLT
A
Q
Q
Q
E
A
Q
K
Q
V
D
Q
I
Q
E
Q
V
S
A
I
Q
A
--
E
Q
S
------
N
L
Q
A
E
N
D
R
L
--
Q
--
A
E
-
S
K
K
L
E
G
E
I
T
E
L
S
K
N
I
V
S
R
N
Q
S
--
L
E
K
Q
A
R
S
A
Q
T
N
G
A
V
---
T
S
-
Y
I
N
T
I
V
N
S
K
S
I
T
E
A
IS
R
V
A
A
M
----------------
S
E
I
--
V
S
-
A
N
N
K
M
L
E
Q
Q
-----------------
K
A
D
K
K
A
I
S
E
K
Q
V
A
N
N
D
A
I
N
---
T
V
I
A
N
Q
Q
K
L
A
D
D
--
A
Q
A
L
T
T
--------
K
Q
A
E
L
K
A
A
E
L
S
L
A
A
E
K
A
------
T
A
E
G
E
K
A
S
L
L
E
Q
K
A
A
A
E
----------
A
E
A
R
---
A
A
A
V
A
E
A
A
Y
K
E
K
R
A
S
Q
Q
Q
S
V
L
A
S
A
N
-
T
N
L
T
A
Q
V
Q
A
V
S
E
S
---
A
----
A
A
P
V
-
R
A
K
V
R
P
T
Y
S
T
N
-------------
A
S
S
Y
P
I
G
E
C
T
W
G
V
-
K
T
L
-
A
P
W
A
G
D
Y
W
G
N
G
A
Q
W
A
T
S
A
A
A
A
G
F
R
T
G
S
T
P
Q
V
G
A
I
A
C
W
--------
N
DG
G
Y
G
H
V
A
V
V
T
A
V
E
S
--------------
T
T
R
I
Q
-
V
S
E
S
N
Y
A
-----
G
N
R
T
I
G
---------
N
H
R
G
W
F
N
P
T
T
T
S
E
G
F
V
T
Y
I
Y
AD-------------------------------------
39
HHSearch
45.78
20%
-45
- C3 -
3R4K
-
?
A:
[6-54]
----------
S
K
A
L
T
L
L
T
Y
F
N
----
H
--
G
R
L
------
E
I
G
L
S
D
L
T
R
--
L
--
S
G
-
M
N
K
A
T
V
Y
R
L
M
S
E
L
Q
E
A
G
F
V
E
Q
--
V
E
G
A
R
S
Y
R
L
G
P
Q
V
L
---
R
L
-
A
A
L
R
E
A
S
V
P
I
L
S
A
S
--
R
R
V
L
R
----------------
E
L
S
--
E
D
-
T
G
E
T
T
H
L
S
L
-----------------
L
Q
G
E
Q
L
A
S
L
S
H
A
Y
S
S
R
N
A
T
---
K
V
M
M
E
D
A
E
V
L
T
F
--
H
G
T
A
S
G
--------
L
A
V
L
A
Y
S
E
P
S
F
V
D
A
V
L
A
A
-
P
L
T
A
R
T
P
Q
T
Q
T
D
P
A
A
I
R
A
E
I
A
----------
E
V
R
R
---
T
G
L
A
Q
S
I
G
G
F
E
A
E
V
H
S
H
A
V
P
I
F
G
P
D
-
R
A
V
L
G
A
L
A
V
A
A
P
T
---
S
R
M
T
P
D
Q
K
R
-
T
I
P
P
A
L
R
A
A
G
L
-------------
S
L
T
E
R
I
G
G
A
C
P
P
E
-
F
P
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
45.09
20%
-6
- C3 -
2JT1
-
?
A:
[2-57]
--------
S
E
S
I
V
T
K
I
I
S
I
V
Q
-------
E
R
Q
N
M
D
D
G
A
P
V
K
T
R
D
I
A
D
--
A
--
A
G
-
L
S
I
Y
Q
V
R
L
Y
L
E
Q
L
H
D
V
G
V
L
E
K
--
V
N
A
G
K
G
V
P
G
L
W
R
L
L
---
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
44.29
10%
-27
- C3 -
2W25
-
?
A:
[5-53]
--------
L
D
D
I
D
R
I
L
V
R
E
L
-----
A
--
A
D
G
------
R
A
T
L
S
E
L
A
T
--
R
--
A
G
-
L
S
V
S
A
V
Q
S
R
V
R
R
L
E
S
R
G
V
V
Q
G
--
Y
S
A
R
I
N
P
E
A
V
G
H
L
L
---
S
A
-
F
V
A
I
T
P
L
D
P
S
Q
P
D
D
--
A
P
A
R
L
----------------
E
H
I
--
E
E
-
V
E
S
C
Y
S
V
A
G
-----------------
E
A
S
Y
V
L
L
V
R
V
A
S
A
R
A
L
E
D
L
---
L
Q
R
I
R
T
T
A
N
V
R
T
--
R
S
T
I
I
L
--------
N
T
F
Y
S
D
R
Q
H
I
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
44.07
22%
-21
- C3 -
1I1G
-
REG7_PYRFU
A:
[2-51]
--------
I
D
E
R
D
K
I
I
L
E
I
L
-----
E
--
K
D
A
------
R
T
P
F
T
E
I
A
K
--
K
--
L
G
-
I
S
E
T
A
V
R
K
R
V
K
A
L
E
E
K
G
I
I
E
G
--
Y
T
I
K
I
N
P
K
K
L
G
Y
S
L
---
V
T
-
I
T
G
V
D
T
K
P
E
K
L
F
E
V
--
A
E
K
L
K
----------------
E
Y
D
--
F
V
-
K
E
L
Y
L
S
S
G
D
-----------------
H
M
I
M
A
V
I
W
A
K
D
G
E
D
L
A
E
I
I
---
S
N
K
I
G
K
I
E
G
V
T
K
--
V
C
P
A
I
I
--------
L
E
K
L
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
43.13
17%
-4
- C3 -
3EYI
2
ZBP1_HUMAN
A:
[10-57]
----------
Q
R
E
E
D
I
Y
R
F
L
-----
K
--
D
N
G
------
P
Q
R
A
L
V
I
A
Q
--
A
--
L
G
M
R
T
A
K
D
V
N
R
D
L
Y
R
M
K
S
R
H
L
L
D
M
--
D
E
Q
S
K
A
W
T
I
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------