@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0096: (2015-11-28 )
MSKIIGIDLGTTNSAVAVLEGTESKIIANPEGNRTTPSVVSFKNGEIIVGDAAKRQAVTNPDTVISIKSKMGTSEKVSANGKEYTPQEISAMILQYLKGYAEDYLGEKVEKAVITVPAYFNDAQRQATKDAGKIAGLEVERIVNEPTAAALAYGMDKTDKDEKILVFDLGGGTFDVSILELGDGVFDVLATAGDNKLGGDDFDQKIIDFLVEEFKKENGIDLSQDKMALQRLKDAAEKAKKDLSGVTQTQISLPFITAGSAGPLHLEMSLSRAKFDDLTRDLVERTKTPVRQALSDAGLSLSEIDEVILVGGSTRIPAVVEAVKAETGKEPNKSVNPDEVVAMGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGRFQLTDIPAAPRGIPQIEVTFDIDKNGIVSVKAKDLGTQKEQHIVIQSNSGLTDEEIDKMMKDAEANAEADAKRKEEVDLKNEVDQAIFATEKTIKETEGKGFDTERDAAQSALDELKKAQESGNLDDMKAKLEALNEKAQALAVKLYEQAAAAQQAAQGAEGAQSADSSSKGDDVVDGEFTEK
Atome Classification :
(91 SA)
...--......10........20........30........40.-.--......50........60----------------.-...--------------.--------------...----------------------------70----------.-------------------..---------------.-------------------------.------------------------.---------------------------.----------------------------.80-------------.------------..------------..--....90........100.......110.......120.......130.......140.......150....--.---.------.------160.-......170.......180---........-190.......200.......210......-.220.......230.......240....-...250.......260.......270.......280.-......290.......300.......310.......320..-.-.--.-.-.330.......340.......350...----....360.......370...----..----..380.......390.......400......-.410.......420.......430.....-..440.......450---.......----460.......470.-..-.-...480.......490.......500.......510.......520-.-......530.......540.......550--.........560.......570.......580.......590.......600.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
K
--
I
I
G
I
D
LGTTN
S
A
V
A
V
L
EGTE
S
K
I
I
ANPEGNRTT
P
S
V
V
S
F-K--NG
E
I
I
VGDAAKRQAVTNP----------------D-
T
V
I
--------------
S
--------------
I
KS----------------------------KM----------G-------------------TS---------------E-------------------------K------------------------V---------------------------S----------------------------AN--------------G------------KE------------Y
T
--
P
Q
E
I
S
A
M
I
L
Q
Y
L
K
G
Y
A
E
D
Y
L
G
E
K
V
E
K
A
V
I
T
VPAYF
N
D
A
Q
R
Q
A
T
KDAGKIAGL
E
V
E
R
I
VNEP
T
A
A
A
L
AYGMD--K---T------D------KD
E
K
-
I
L
V
F
DLGG
G
T
F
D
V
S
I
L
EL----G
D
G
V
F
D
V
L
-
A
TAGDNKLGG
D
D
F
D
Q
K
I
I
D
F
L
V
E
E
F
K
KEN-GIDL
S
Q
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
D
LSGV-
T
Q
T
Q
I
S
L
P
F
I
TAGSAG
P
L
H
L
E
M
SLSRA
K
F
D
D
L
T
R
D
L
V
-
E
R
T
K
T
P
V
R
Q
A
L
S
D
AGL
S
L
S
E
ID
E
V
I
L
VGGSTR
I
P
A
V
V
E
A
V
K
-
A
-E--T-G-KEPNKSV
N
P
D
E
V
V
A
MGAAIQG
G
V
I
TGD----V
K
D
V
V
L
L
DVT
P
L
S
L
G
I
E
T
M
G
----
G
V
----
F
T
K
L
IDRNTTIPTSK
S
Q
V
F
STAADNQP
A
V
D
I
-
H
V
LQGERPMAADNKTLG
R
F
Q
LTDIPAAPR-GI
P
Q
I
E
V
T
F
DIDKN
G
---
I
V
S
V
K
AK----DLGTQK
E
Q
H
I
V
I
QS-NS-G-L
T
D
E
E
I
D
K
M
M
K
D
AEANAEADA
K
R
K
E
EV
D
L
K
N
E
V
D
Q
A
I
F
A
T
E
K
T
I
K
E-T-EGKGFD
T
E
R
D
A
A
Q
S
A
L
D
E
L
K
K
A
Q
ESG
N
----
L
D
D
M
K
A
K
L
E
A
L
N
E
K
A
Q
A
L
A
V
K
L
Y
E
Q
A
A
A
A
Q
Q
A
AQGAEGAQSADSSSKGDDVVDGEFTEK
112
HHSearch
93.81
80%
-73
- C1 -
2V7Y
2
DNAK_GEOKA
A:
[1-504]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
--
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
----------------
N
-
T
I
I
--------------
S
--------------
I
K
R
----------------------------
H
M
----------
G
-------------------
T
D
---------------
Y
-------------------------
K
------------------------
V
---------------------------
E
----------------------------
I
E
--------------
G
------------
K
Q
------------
Y
T
--
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
E
-------------
E
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
K
-
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
-
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
-
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
-
R
-
E
--
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
---
I
V
H
V
R
A
K
----
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
-
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
--------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.51
79%
-73
- C1 -
2V7Y
2
DNAK_GEOKA
A:
[1-504]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
--
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
----------------
N
-
T
I
I
--------------
S
--------------
I
K
R
----------------------------
H
M
----------
G
-------------------
T
D
---------------
Y
-------------------------
K
------------------------
V
---------------------------
E
----------------------------
I
E
--------------
G
------------
K
Q
------------
Y
T
--
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
----------
E
------
E
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
K
-
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
-
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
-
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
-
R
-
E
--
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
---
I
V
H
V
R
A
K
----
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
-
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
--------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
92.08
55%
-68
- C1 -
4JN4
12
DNAK_ECOLI
B:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q---------------
N
-
T
L
F
--------------
A
--------------
I
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
-------------------------
Q
DEEVQRDVSIMPFKIIAADNGDAW
V
---------------------------
E
----------------------------
V
K
--------------
G
------------
Q
K
------------
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
------
T
------
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
--
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
---
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
-
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
-----------------------------------
6
PsiBlast_PDB
91.76
55%
-70
- C1 -
4B9Q
1
DNAK_ECOLI
A:
[3-598]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
C
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q---------------
N
-
T
L
F
--------------
A
--------------
I
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
---------------------------
E
----------------------------
V
K
--------------
G
------------
Q
K
------------
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
------
T
------
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
--
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
---
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
C
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
-
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
-------------------------------------
2
PsiBlast_PDB
91.33
79%
-74
- C3 -
4ANI
-
DNAK_GEOKA
C:
[1-509]
M
S
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
P
E
G
N
R
T
T
P
S
V
V
A
F
-
K
--
N
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
----------------
N
-
T
I
I
--------------
S
--------------
I
K
R
----------------------------
H
M
----------
G
-------------------
T
D
---------------
Y
-------------------------
K
------------------------
V
---------------------------
E
----------------------------
I
E
--------------
G
------------
K
Q
------------
Y
T
--
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
----------
E
------
E
D
Q
T
-
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
----
G
D
G
V
F
E
V
K
-
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
-
G
I
D
L
S
K
D
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
G
V
-
T
Q
T
Q
I
S
L
P
F
I
S
A
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
-
R
-
E
--
L
-
G
-
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
E
----
V
K
D
V
V
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
F
T
K
L
I
E
R
N
T
T
I
P
T
S
K
S
Q
V
F
T
T
A
A
D
N
Q
T
T
V
D
I
-
H
V
L
Q
G
E
R
P
M
A
A
D
N
K
S
L
G
R
F
Q
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
---
I
V
H
V
R
A
K
----
D
L
G
T
N
K
E
Q
S
I
T
I
K
S
-
S
S
-
G
-
L
S
E
E
E
I
Q
R
M
I
K
E
A
E
E
N
A
E
A
D
R
K
R
K
E
A
A
E
L
R
N
E
A
D
---------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
91.20
55%
-65
- C1 -
4JNE
11
DNAK_ECOLI
B:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q---------------
N
-
T
L
F
--------------
A
--------------
I
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
-------------------------
Q
DEEVQRDVSIMPFKIIAADNGDAW
V
---------------------------
E
----------------------------
V
K
--------------
G
------------
Q
K
------------
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
------
T
------
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
DEVD
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
--
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
---
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
-
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
-----------------------------------
4
PsiBlast_PDB
91.06
55%
-67
- C1 -
4JN4
12
DNAK_ECOLI
A:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q---------------
N
-
T
L
F
--------------
A
--------------
I
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
---------------------------
E
----------------------------
V
K
--------------
G
------------
Q
K
------------
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
------
T
------
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
--
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
---
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
-
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
-----------------------------------
5
PsiBlast_PDB
90.97
55%
-65
- C1 -
4JNE
12
DNAK_ECOLI
A:
[3-594]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q---------------
N
-
T
L
F
--------------
A
--------------
I
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
I
MP
F
K
I
I
A
A
DNG
D
A
W
V
---------------------------
E
----------------------------
V
K
--------------
G
------------
Q
K
------------
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
------
T
------
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
A
F
D
I
S
I
I
E
I
D
E
V
D
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
--
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
M
G
G
----
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
---
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
E
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
-
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
Q
-----------------------------------
3
PsiBlast_PDB
90.25
56%
-71
- C3 -
2KHO
-
DNAK_ECOLI
A:
[4-598]
-----
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q---------------
N
-
T
L
F
--------------
A
--------------
I
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
-------------------------
Q
D
E
E
V
Q
R
D
V
S
IMP
F
K
I
I
A
A
DNG
D
A
W
V
---------------------------
E
----------------------------
V
K
--------------
G
------------
Q
K
------------
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
---
G
------
T
------
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D
EVD
G
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
P
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
--
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
G
D
----
V
K
D
V
L
L
L
D
V
T
P
L
S
L
G
I
E
T
M
G
----
G
V
----
M
T
T
L
I
A
K
N
T
T
I
P
T
K
H
S
Q
V
F
S
T
A
E
D
N
Q
S
A
V
T
I
-
H
V
L
Q
G
E
R
K
R
A
A
D
N
K
S
L
G
Q
F
N
L
D
G
I
N
P
A
P
R
-
G
M
P
Q
I
E
V
T
F
D
I
D
A
D
G
---
I
L
H
V
S
A
K
----
D
K
N
S
G
K
E
Q
K
I
T
I
K
A
-
S
S
-
G
-
L
N
E
D
E
I
Q
K
M
V
R
D
A
E
A
N
A
E
A
D
R
K
F
D
E
L
V
Q
T
R
N
Q
G
D
H
L
L
H
S
T
R
K
Q
V
E
E
-
A
-
G
D
K
L
P
A
D
D
K
T
A
I
E
S
A
L
T
A
L
E
T
A
L
K
G
E
D
----
K
A
A
I
E
A
K
M
Q
E
L
A
Q
V
S
Q
K
L
M
E
I
A
Q
------------------------------------
8
PsiBlast_PDB
85.80
48%
-66
- C1 -
1YUW
-
HSP7C_BOVIN
A:
[1-554]
M
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
A
A
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
----
G
V
----
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
-
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
---
I
L
N
V
S
A
V
----
D
K
S
T
G
K
E
N
K
I
T
I
T
N
-
D
K
-
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
N
M
K
A
T
V
E
----------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.79
49%
-70
- C1 -
3C7N
9
HSP7C_BOVIN
B:
[3-547]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-----
D
L
L
L
L
D
V
T
P
L
S
L
G
I
E
T
A
G
----
G
V
----
M
T
V
L
I
K
R
N
T
T
I
P
T
K
Q
T
Q
T
F
T
T
Y
S
D
N
Q
P
G
V
L
I
-
Q
V
Y
E
G
E
R
A
M
T
K
D
N
N
L
L
G
K
F
E
L
T
G
I
P
P
A
P
R
-
G
V
P
Q
I
E
V
T
F
D
I
D
A
N
G
---
I
L
N
V
S
A
V
----
D
K
S
T
G
K
E
N
K
I
T
I
T
N
-
D
K
-
G
R
L
S
K
E
D
I
E
R
M
V
Q
E
A
E
K
Y
K
A
E
D
E
K
Q
R
D
K
V
S
S
K
N
S
L
E
S
Y
A
F
-----------------------------------------------------------------------------------------------------
111
HHSearch
75.38
27%
-52
- C1 -
3D2F
4
?
A:
[2-634]
-
S
T
--
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
A
R
N
R
G
I
D
I
V
V
N
E
V
S
N
R
S
T
P
S
V
V
G
F
-
G
--
P
K
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
K---------------
N
-
T
V
A
--------------
N
--------------
L
K
R
----------------------------
I
I
----------
G
-------------------
L
D
---------------
Y
-------------------------
H
------------------------
H
---------------------------
P
D
F
E
Q
E
S
K
H
FT
S
K
L
V
E
L
DDK
K
T
G
A
E
V
R
F
A
G
E
--------------
K
------------
H
V
------------
F
S
--
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
--
K
---
T
DLPEGE
E
------
K
P
R
I
-
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
----
K
K
G
Q
L
K
V
L
-
G
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
T
K
Y
-
K
I
D
I
R
E
N
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
S
A
N
-
T
N
A
P
F
S
V
E
S
V
M
N
D
----
V
D
V
S
S
Q
L
S
R
E
E
L
E
E
L
V
K
P
L
L
-
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
-
E
-
A
--
F
-
G
-
K
P
L
S
T
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
P
T
LR--
V
R
P
F
K
F
E
D
I
H
P
Y
S
V
S
Y
S
W
D
K
QVED
E
D
----
H
M
E
V
F
P
A
G
S
S
F
P
S
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
T
D
I
T
Q
L
P
P
---
N
T
P
E
Q
I
A
N
W
E
I
T
G
V
Q
L
P
E
G
Q
D
S
V
P
V
K
L
K
L
R
C
D
P
S
G
---
L
H
T
I
E
E
A
Y
T
I
E
D
T
K
T
V
K
K
D
D
L
T
I
V
A
H
T
F
-
G
-
L
D
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
E
E
Y
-
A
P
F
A
S
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
D
E
G
FDSI
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
R
-------------------------
96
PsiBlast_CBE
74.92
47%
-79
- C1 -
3CQX
1
HSP7C_MOUSE
B:
[10-386]
---P-
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Fugue
74.85
60%
-82
- C1 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
-
T
QD-
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
----------------
Q
-
N
T
L
FAIKRLIGRRFQDE
E
--------------
V
Q
R
----------------------------
D
V
----------
S
-------------------
I
M
---------------
P
FKIIAADNGDAWV------------
E
------------------------
V
---------------------------------------------------------
K
--------------
G
--------------------------
Q
K
MA
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
-----------------
T
G
N
R
T
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
----
D
E
K
T
F
E
V
L
A-
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
-A
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
N-
R
S
I
E
L
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
FG----
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Fugue
74.83
27%
-54
- C1 -
2QXL
3
HSP7F_YEAST
A:
[2-656]
--
T
--
P
F
G
L
D
L
G
N
N
N
S
V
L
A
V
A
R
N
R
G
I
D
I
V
V
N
E
V
S
N
R
S
T
P
S
V
V
G
F
-
G
--
P
K
N
R
Y
L
G
E
T
G
K
N
K
Q
T
S
N
I
----------------
K
N
T
V
A
--------------
N
--------------
L
K
R
IIGLDYHHPD
F
E
Q
E
S
K
H
FT
S
K
L
V
E
L
DDK
K
T
----------
G
-------------------
A
E
---------------
V
-------------------------
R
------------------------
F
---------------------------
A
----------------------------
G
E
--------------
K
------------
H
V
------------
F
S
--
A
T
Q
L
A
A
M
F
I
D
K
V
K
D
T
V
K
Q
D
T
K
A
N
I
T
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
R
I
A
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
S
Y
G
I
F
--
K
---
T
------
D
LPEGE
E
K
P
R
I
-
V
A
F
V
D
I
G
H
S
S
Y
T
C
S
I
M
A
F
----
K
K
G
Q
L
K
V
L
-
G
T
A
C
D
K
H
F
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
T
K
Y
-
K
I
D
I
R
E
N
P
K
A
Y
N
R
I
L
T
A
A
E
K
L
K
K
V
L
S
A
N
-
T
N
A
P
F
S
V
E
S
V
M
N
D
----
V
D
V
S
S
Q
L
S
R
E
E
L
E
E
L
V
K
P
L
L
-
E
R
V
T
E
P
V
T
K
A
L
A
Q
A
K
L
S
A
E
E
V
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
-
E
-
A
--
F
-
G
-
K
P
L
S
T
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
S
-------
R
P
F
K
F
E
D
I
H
P
Y
S
V
S
Y
S
W
D
K
----
Q
V
EDED
H
M
E
V
F
P
A
G
S
S
F
P
S
T
K
L
I
T
L
N
R
T
G
D
F
S
M
A
A
S
Y
-
T
D
I
T
Q
L
P
P
N
T
P
E
--
Q
I
A
N
W
E
I
T
--------
D
S
V
P
V
K
L
K
L
R
C
D
P
S
G
L
H
T
I
E
E
A
Y
T
I
----
E
D
K
T
V
K
K
D
D
L
T
I
V
A
-
H
T
F
G
-
L
D
A
K
K
L
N
E
L
I
E
K
E
N
E
M
L
A
Q
D
K
L
V
A
E
T
E
D
R
K
N
T
L
E
E
Y
I
Y
T
L
R
G
K
L
E
E
-
E
Y
A
P
F
A
S
D
A
E
K
T
K
L
Q
G
M
L
N
K
A
E
E
W
L
Y
D
E
G
----
F
D
S
I
K
A
K
Y
I
A
K
Y
E
E
L
A
S
L
G
N
I
I
R
G
R
Y
L
A
K
E
E
E
K
K
Q
A
I
R
S
K
Q
------------------
90
PsiBlast_CBE
74.73
47%
-77
- C1 -
3FZM
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
74.64
47%
-78
- C1 -
3LDQ
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.63
55%
-76
- C1 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
--
K
--
I
I
G
I
D
L
G
T
T
N
S
C
V
A
I
M
D
G
T
T
P
R
V
L
E
N
A
E
G
D
R
T
T
P
S
I
I
A
Y
T
Q
--
D
G
E
T
L
V
G
Q
P
A
K
R
Q
A
V
T
N
P
Q---------------
N
-
T
L
F
--------------
A
--------------
I
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
-------------------------
Q
DEEVQRDVSIMPFKIIAADNGDAW
V
---------------------------
E
----------------------------
V
K
--------------
G
------------
Q
K
------------
M
A
--
P
P
Q
I
S
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
G
E
P
V
T
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
--
K
----------
T
------
G
N
R
T
-
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
E
I
D----
E
K
T
F
E
V
L
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
K
D
Q
-
G
I
D
L
R
N
D
P
L
A
M
Q
R
L
K
E
A
A
E
K
A
K
I
E
L
S
S
A
-
Q
Q
T
D
V
N
L
P
Y
I
T
A
D
A
T
G
P
K
H
M
N
I
K
V
T
R
A
K
L
E
S
L
V
E
D
L
V
-
N
R
S
I
E
L
L
K
V
A
L
Q
D
A
G
L
S
V
S
D
I
D
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
-
E
-
F
--
F
-
G
-
K
E
P
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
74.47
50%
-72
- C1 -
3GL1
6
HSP75_YEAST
A:
[13-387]
------
I
G
I
D
L
G
T
T
Y
S
C
V
A
T
Y
E
S
S
-
V
E
I
I
A
N
E
Q
G
N
R
V
T
P
S
F
V
A
F
-
T
--
P
E
E
R
L
I
G
D
A
A
K
N
Q
A
A
L
N
P
R---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
FDD
E
S
V
Q
K
D
M
K
T
WP
F
K
-------------------------
V
------------------------
I
---------------------------
D
----------------------------
V
D
--------------
G
N
P
V
I
E
V
Q
Y
LE
E
T
K
T
------------
F
S
--
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
A
K
I
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
A
I
S
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
AG
K
---
S
------
E
------
K
E
R
H
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
H
I
----
A
G
G
V
Y
T
V
K
-
S
T
S
G
N
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
H
F
K
A
E
F
K
K
K
T
-
G
L
D
I
S
D
D
A
R
A
L
R
R
L
R
T
A
A
E
R
A
K
R
T
L
S
S
V
-
T
Q
T
T
V
E
V
D
S
L
F
D
G
E
----
D
F
E
S
S
L
T
R
A
R
F
E
D
L
N
A
A
L
F
-
K
S
T
L
E
P
V
E
Q
V
L
K
D
A
K
I
S
K
S
Q
I
D
E
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
S
D
F
-
F
--
D
-
G
-
K
Q
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
G
A
I
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
74.29
49%
-79
- C1 -
3A8Y
1
HS71A_HUMAN
A:
[11-387]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
K
---------------
F
GD
P
V
V
Q
S
D
MKHWP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
---------------------------
S
----------------------------
Y
K
--------------
G
E
T
----------
K
A
------------
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
------
G
------
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
74.23
49%
-72
- C1 -
3FE1
2
HSP76_HUMAN
C:
[24-402]
-
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
RKFAD
T
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
---------------
E
GG
K
P
K
V
-------------------
R
------------------------
V
---------------------------
C
----------------------------
Y
R
--------------
G
E
D
----------
K
T
------------
F
Y
--
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
R
------
G
------
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
-
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
T
L
E
I
D
S
L
F
E
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
74.20
50%
-71
- C1 -
3GL1
7
HSP75_YEAST
B:
[13-387]
------
I
G
I
D
L
G
T
T
Y
S
C
V
A
T
Y
E
S
S
-
V
E
I
I
A
N
E
Q
G
N
R
V
T
P
S
F
V
A
F
-
T
--
P
E
E
R
L
I
G
D
A
A
K
N
Q
A
A
L
N
P
R---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
FDD
E
S
V
Q
K
D
M
K
T
WP
F
K
-------------------------
V
------------------------
I
---------------------------
D
----------------------------
V
D
--------------
G
N
P
V
I
E
V
Q
Y
LE
E
T
K
T
------------
F
S
--
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
A
E
A
K
I
G
K
K
V
E
K
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
A
I
S
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
G
AG
K
---
S
------
E
------
K
E
R
H
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
H
I
----
A
G
G
V
Y
T
V
K
-
S
T
S
G
N
T
H
L
G
G
Q
D
F
D
T
N
L
L
E
H
F
K
A
E
F
K
K
K
T
-
G
L
D
I
S
D
D
A
R
A
L
R
R
L
R
T
A
A
E
R
A
K
R
T
L
S
S
V
-
T
Q
T
T
V
E
V
D
S
L
F
D
G
E
----
D
F
E
S
S
L
T
R
A
R
F
E
D
L
N
A
A
L
F
-
K
S
T
L
E
P
V
E
Q
V
L
K
D
A
K
I
S
K
S
Q
I
D
E
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
S
D
F
-
F
--
D
-
G
-
K
Q
L
E
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
G
A
I
L
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
HHSearch
74.19
51%
-72
- C1 -
3I33
3
HSP72_HUMAN
A:
[23-402]
-
M
P
--
A
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
I
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
K
---------------
F
-------------------------
E
------------------------
D
---------------------------
A
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
Q
V
E
Y
K-
G
E
--------------
T
------------
K
T
------------
F
F
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
GCA---
G
------
G
E
K
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
-
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
-
D
-
F
--
F
-
N
G
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
74.12
48%
-76
- C1 -
1HJO
2
HS71A_HUMAN
A:
[5-380]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
K
---------------
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
---------------------------
S
----------------------------
Y
K
--------------
G
E
T
----------
K
A
------------
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
------
G
------
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
74.12
49%
-68
- C1 -
3FE1
4
HSP76_HUMAN
B:
[23-403]
M
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
RKFAD
T
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
---------------
E
GG
K
P
K
V
-------------------
R
------------------------
V
---------------------------
C
----------------------------
Y
R
--------------
G
E
D
----------
K
T
------------
F
Y
--
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
R
------
G
------
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
-
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
T
L
E
I
D
S
L
F
E
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
74.11
47%
-73
- C1 -
1NGF
1
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
N
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
74.07
49%
-72
- C1 -
3ATV
3
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
K
---------------
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
---------------------------
S
----------------------------
Y
K
--------------
G
E
T
----------
K
A
------------
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
------
G
------
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
73.97
48%
-73
- C1 -
3IUC
2
GRP78_HUMAN
A:
[28-404]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
T
---------------
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
---------------------------
D
----------------------------
I
G
--------------
G
G
Q
T
---------
K
T
------------
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
------
E
------
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
F
F
--
N
-
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
73.91
47%
-75
- C1 -
1NGI
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
73.90
48%
-76
- C1 -
3LDP
1
GRP78_HUMAN
A:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
T
---------------
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
---------------------------
D
----------------------------
I
G
--------------
G
G
Q
T
---------
K
T
------------
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
------
E
------
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
F
F
--
N
-
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
PsiBlast_CBE
73.86
47%
-78
- C1 -
3FZH
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
73.85
48%
-75
- C1 -
4IO8
1
HS71A_HUMAN
A:
[7-379]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
K
---------------
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
---------------------------
S
----------------------------
Y
K
--------------
G
D
T
----------
K
A
------------
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
------
G
------
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
PsiBlast_CBE
73.74
47%
-76
- C1 -
3FZF
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
73.73
47%
-71
- C1 -
1ATR
3
HSP7C_BOVIN
A:
[2-383]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
V
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
73.71
47%
-72
- C1 -
2QWM
5
HSP7C_BOVIN
A:
[4-384]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
73.70
47%
-74
- C1 -
1NGG
1
HSP7C_BOVIN
A:
[3-381]
--
K
G
P
A
V
G
I
S
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.68
49%
-72
- C1 -
3FE1
2
HSP76_HUMAN
A:
[23-403]
M
E
L
--
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
Q
G
R
V
E
I
L
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
V
G
D
A
A
K
S
Q
A
A
L
N
P
H---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
RKFAD
T
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
---------------
E
GG
K
P
K
V
-------------------
R
------------------------
V
---------------------------
C
----------------------------
Y
R
--------------
G
E
D
----------
K
T
------------
F
Y
--
P
E
E
I
S
S
M
V
L
S
K
M
K
E
T
A
E
A
Y
L
G
Q
P
V
K
H
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
R
------
G
------
A
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
V
L
S
I
----
D
A
G
V
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
M
E
E
F
R
R
K
H
-
G
K
D
L
S
G
N
K
R
A
L
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
T
L
E
I
D
S
L
F
E
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
V
L
M
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
73.64
47%
-76
- C1 -
3M3Z
1
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
73.61
48%
-77
- C1 -
3I33
3
HSP72_HUMAN
A:
[26-402]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
----------------
T
-
N
T
I
FDAKRLIGRKFED
A
T
--------------
V
Q
S
----------------------------
D
M
K
H
WP
F
R
V
V
S
E
G
-------------------
G
K
---------------
P
-------------------------
K
------------------------
V
---------------------------
Q
V
E
Y
K------------------------
G
E
--------------
T
------------
K
T
------------
F
F
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
G
K
V
H
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
T
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
KGC
A
------
G
------
G
E
K
N
-
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
R
K
H
-
K
K
D
I
G
P
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
V
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
G
Q
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
73.56
47%
-77
- C1 -
3FZK
3
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
73.55
47%
-73
- C1 -
1NGJ
2
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
73.49
47%
-75
- C1 -
1BA1
4
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
K
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
73.45
47%
-73
- C1 -
2QWM
5
HSP7C_BOVIN
B:
[4-384]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DDAVVQSDMKHWPFMVVNDAGRPKV
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
ET----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
73.42
47%
-72
- C1 -
4H5T
3
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
73.37
47%
-73
- C1 -
2QWL
4
HSP7C_BOVIN
B:
[4-384]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DDAVVQSDMKHWPFMVVNDAGRPKV
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
ET----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
73.35
49%
-73
- C1 -
3AY9
5
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
K
---------------
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
---------------------------
S
----------------------------
Y
K
--------------
G
E
T
----------
K
A
------------
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
------
G
------
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
73.30
47%
-75
- C1 -
1NGD
3
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
N
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
73.18
47%
-74
- C1 -
1NGA
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
S
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
73.15
47%
-75
- C1 -
1HX1
1
HSP7C_BOVIN
A:
[26-400]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
73.14
47%
-73
- C1 -
1ATS
2
HSP7C_BOVIN
A:
[2-383]
-
S
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
E
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
73.14
48%
-70
- C1 -
3LDL
1
GRP78_HUMAN
A:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
T
---------------
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KT
K
P
Y
I
Q
------------------------
V
---------------------------
D
----------------------------
I
G
--------------
G
G
Q
T
---------
K
T
------------
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
------
E
------
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
F
F
--
N
-
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
73.13
47%
-75
- C1 -
1NGH
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
N
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
73.13
47%
-76
- C1 -
1HPM
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
73.12
49%
-72
- C1 -
3JXU
2
HS71A_HUMAN
A:
[29-403]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
K
---------------
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
---------------------------
S
----------------------------
Y
K
--------------
G
E
T
----------
K
A
------------
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
------
G
------
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
73.10
47%
-75
- C1 -
1BUP
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
S
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
73.08
47%
-75
- C1 -
1NGB
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
Q
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
73.08
47%
-73
- C1 -
2QWL
4
HSP7C_BOVIN
A:
[4-384]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
K-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
73.07
47%
-73
- C1 -
3HSC
5
HSP7C_BOVIN
A:
[3-383]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
73.04
46%
-74
- C1 -
2QWN
5
HSP7C_BOVIN
A:
[3-385]
--
K
G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.96
49%
-73
- C1 -
3ATU
4
HS71A_HUMAN
A:
[11-386]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
K
---------------
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
---------------------------
S
----------------------------
Y
K
--------------
G
E
T
----------
K
A
------------
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
------
G
------
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
PsiBlast_CBE
72.95
47%
-77
- C1 -
1BA0
5
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
K
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
72.94
47%
-74
- C1 -
3KVG
4
?
B:
[22-400]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
E
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
R
N
P
----------------
E
-
N
T
V
FDAKRLIGRKFDDQ
A
--------------
V
Q
S
----------------------------
D
M
THWPFKVVR-
G
-------------------
P
K
---------------
D
-------------------------
K
PI----------------------
I
---------------------------
S
----------------------------
V
N
YLGE----------
K
------------
K
E
------------
F
H
--
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
G
------
T
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
E
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
Q
D
F
K
R
K
N
R
G
M
D
L
T
T
N
A
R
A
L
R
R
L
R
T
Q
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
T
I
E
L
D
S
L
Y
E
G
----
I
D
Y
S
V
A
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
-
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
-
V
Q
A
L
I
-
Q
-
E
FF
N
-
G
-
K
E
P
C
K
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
72.92
48%
-72
- C1 -
3IUC
3
GRP78_HUMAN
C:
[28-406]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
T
---------------
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
---------------------------
D
----------------------------
I
G
--------------
G
GQT---------
K
T
------------
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
-----------------
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
F
F
--
N
-
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
72.86
46%
-73
- C1 -
2QWQ
5
HSP7C_BOVIN
A:
[4-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
72.84
47%
-69
- C1 -
4H5R
10
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
72.83
46%
-73
- C1 -
2QWR
4
HSP7C_BOVIN
A:
[4-386]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
72.82
47%
-74
- C1 -
1NGE
1
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
MKHWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
S
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
72.80
54%
-69
* C1 *
3QFU
3
GRP78_YEAST
A:
[18-393]
-
G
T
--
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
--
D
D
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q---------------
N
-
T
I
F
--------------
D
--------------
I
K
R
----------------------------
L
I
----------
G
-------------------
L
K
---------------
Y
-------------------------
N
------------------------
D
R
S
V
Q
K
D
I
K
H
LP
F
N
V
V
N
K
DG
K
P
A
V
E
V
S
V
K
----------------------------
G
E
--------------
K
------------
K
V
------------
F
T
--
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
S
------
D
------
K
E
H
Q
-
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
----
E
N
G
V
F
E
V
Q
-
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
-
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
-
M
S
T
R
I
E
I
D
S
F
V
D
G
----
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
-
S
-
Y
--
F
-
D
G
K
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
72.77
47%
-66
- C1 -
4H5N
9
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
72.75
46%
-72
- C1 -
2QWO
7
HSP7C_BOVIN
A:
[4-390]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
72.73
49%
-73
- C1 -
3A8Y
1
HS71A_HUMAN
B:
[11-385]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
K
---------------
F
GD
P
V
V
Q
S
D
M
K
HWP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
---------------------------
S
----------------------------
Y
K
--------------
G
E
T
----------
K
A
------------
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
------
G
--------
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
72.62
49%
-74
- C1 -
2E8A
2
HS71A_HUMAN
A:
[10-385]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
K
---------------
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
---------------------------
S
----------------------------
Y
K
--------------
G
E
T
----------
K
A
------------
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
------
G
------
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
72.59
46%
-76
- C1 -
2QWP
7
HSP7C_BOVIN
A:
[4-389]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
C
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
KSEN
V
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
72.58
46%
-77
- C1 -
1KAX
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
----------------
T
-
N
T
V
--------------
F
DAMRLIGRRFDD
A
V
V
Q
S
----------------------------
D
M
----------
K
-------------------
H
W
---------------
P
-------------------------
F
------------------------
M
---------------------------
V
----------------------------
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
------------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
72.55
48%
-75
- C1 -
1S3X
5
HS71A_HUMAN
A:
[7-382]
------
I
G
I
D
L
G
T
T
Y
S
C
I
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
L
N
P
Q---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
K
---------------
F
GD
P
V
V
Q
S
D
M
K
H
WP
F
Q
V
I
N
D
GD
K
P
K
V
Q
------------------------
V
---------------------------
S
----------------------------
Y
K
--------------
G
E
T
----------
K
A
------------
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
Y
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
R
---
T
------
G
------
K
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
N
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
L
E
I
D
S
L
F
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
S
D
L
F
-
R
S
T
L
E
P
V
E
K
A
L
R
D
A
K
L
D
K
A
Q
I
H
D
L
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
72.51
47%
-69
- C1 -
4H5R
8
HSP7C_HUMAN
B:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DDAVVQSDMKHWPFMVVNDAGRPKV
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
ET----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
72.51
47%
-70
- C1 -
4H5W
4
HSP7C_HUMAN
B:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DDAVVQSDMKHWPFMVVNDAGRPKV
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
ET----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.50
50%
-72
- C1 -
3QFU
3
GRP78_YEAST
A:
[20-394]
-----
V
I
G
I
D
L
G
T
T
Y
S
C
V
A
V
M
K
N
G
K
T
E
I
L
A
N
E
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
--
D
D
E
R
L
I
G
D
A
A
K
N
Q
V
A
A
N
P
Q---------------
N
-
T
I
F
--------------
D
--------------
I
K
R
----------------------------
L
I
----------
G
-------------------
L
K
---------------
Y
ND
R
S
V
Q
K
D
I
K
H
LP
F
N
V
V
N
K
DG
K
P
A
V
E
------------------------
V
---------------------------
S
----------------------------
V
K
--------------
G
E
K
----------
K
V
------------
F
T
--
P
E
E
I
S
G
M
I
L
G
K
M
K
Q
I
A
E
D
Y
L
G
T
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
S
------
D
------
K
E
H
Q
-
I
I
V
Y
D
L
G
G
G
T
F
D
V
S
L
L
S
I
----
E
N
G
V
F
E
V
Q
-
A
T
S
G
D
T
H
L
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
K
K
H
-
G
I
D
V
S
D
N
N
K
A
L
A
K
L
K
R
E
A
E
K
A
K
R
A
L
S
S
Q
-
M
S
T
R
I
E
I
D
S
F
V
D
G
----
I
D
L
S
E
T
L
T
R
A
K
F
E
E
L
N
L
D
L
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
D
S
G
L
E
K
K
D
V
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
-
S
-
Y
--
F
D
G
-
K
K
A
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
PsiBlast_CBE
72.49
47%
-74
- C1 -
3FZL
2
HSP7C_HUMAN
A:
[7-381]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
72.49
47%
-69
- C1 -
4H5V
9
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
DAG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
PsiBlast_CBE
72.46
46%
-79
- C1 -
1KAY
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
----------------
T
-
N
T
V
--------------
F
DAARLIGRRFDD
A
V
V
Q
S
----------------------------
D
M
----------
K
-------------------
H
W
---------------
P
-------------------------
F
------------------------
M
---------------------------
V
----------------------------
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
------------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
72.45
47%
-73
- C1 -
1NGC
2
HSP7C_BOVIN
A:
[4-381]
---G
P
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
HWP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
S
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
72.34
47%
-75
- C1 -
3KVG
4
?
A:
[22-399]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
E
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
R
N
P
----------------
E
-
N
T
V
FDAKRLIGRKFDD
Q
A
--------------
V
Q
S
----------------------------
D
M
T
H
WP
F
K
V
V
R
-
G
-------------------
P
K
---------------
D
-------------------------
K
P
I
----------------------
I
---------------------------
S
----------------------------
V
N
Y
LG
E
----------
K
------------
K
E
------------
F
H
--
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
G
------
T
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
E
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
Q
D
F
K
R
K
N
R
G
M
D
L
T
T
N
A
R
A
L
R
R
L
R
T
Q
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
T
I
E
L
D
S
L
Y
E
G
----
I
D
Y
S
V
A
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
-
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
-
V
Q
A
L
I
-
Q
-
E
F
F
N
-
G
-
K
E
P
C
K
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
72.27
48%
-74
- C1 -
3LDL
2
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
T
---------------
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
---------------------------
D
----------------------------
I
G
--------------
G
GQT---------
K
T
------------
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
------
E
------
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
F
F
--
N
-
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
72.24
47%
-78
- C1 -
3L4I
3
?
A:
[22-399]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
W
R
N
D
T
V
D
I
V
P
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
E
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
R
N
P
----------------
E
-
N
T
V
FDAKRLIGRKFDD
Q
A
--------------
V
Q
S
----------------------------
D
M
T
H
WP
F
K
V
V
R
-
G
-------------------
P
K
---------------
D
-------------------------
K
P
I
----------------------
I
---------------------------
S
----------------------------
V
N
Y
LG
E
----------
K
------------
K
E
------------
F
H
--
A
E
E
I
S
A
M
V
L
Q
K
M
K
E
I
S
E
A
Y
L
G
R
Q
I
K
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
A
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
G
------
T
G
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
E
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
E
F
C
V
Q
D
F
K
R
K
N
R
G
M
D
L
T
T
N
A
R
A
L
R
R
L
R
T
Q
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
T
I
E
L
D
S
L
Y
E
G
----
I
D
Y
S
V
A
I
S
R
A
R
F
E
E
L
C
A
D
Y
F
-
R
A
T
L
A
P
V
E
K
V
L
K
D
A
G
M
D
K
R
S
V
H
D
V
V
L
V
G
G
S
T
R
I
P
K
-
V
Q
A
L
I
-
Q
-
E
F
F
N
-
G
-
K
E
P
C
K
A
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
N
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
72.10
47%
-69
- C1 -
4H5W
5
HSP7C_HUMAN
A:
[6-382]
------
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
T---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
R
---------------
F
DD
A
V
V
Q
S
D
M
K
H
WP
F
M
V
V
N
D
AG
R
P
K
V
Q
------------------------
V
---------------------------
E
----------------------------
Y
K
--------------
G
E
T
----------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
G
D
----
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
PsiBlast_CBE
72.08
46%
-77
- C1 -
1KAZ
6
HSP7C_BOVIN
A:
[4-381]
---GP
A
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
----------------
T
-
N
T
V
--------------
F
DAERLIGRRFDD
A
V
V
Q
S
----------------------------
D
M
----------
K
-------------------
H
W
---------------
P
-------------------------
F
------------------------
M
---------------------------
V
----------------------------
V
N
D
AG
R
P
K
V
Q
V
E
Y
KG
E
T
------------
K
S
------------
F
Y
--
P
E
E
V
S
S
M
V
L
T
K
M
K
E
I
A
E
A
Y
L
G
K
T
V
T
N
A
V
V
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
K
------
V
------
G
A
E
R
N
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
E
D
G
I
F
E
V
K
-
S
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
M
V
N
H
F
I
A
E
F
K
R
K
H
-
K
K
D
I
S
E
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
S
I
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
N
A
D
L
F
-
R
G
T
L
D
P
V
E
K
A
L
R
D
A
K
L
D
K
S
Q
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
-
F
--
N
-
G
-
K
E
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
71.98
48%
-71
- C1 -
3LDO
1
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
T
---------------
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
---------------------------
D
----------------------------
I
G
--------------
G
GQT---------
K
T
------------
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
------
E
------
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
F
F
--
N
-
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
71.92
48%
-70
- C1 -
3LDO
1
GRP78_HUMAN
A:
[7-384]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
T
---------------
W
ND
P
S
V
Q
Q
D
I
K
F
LP
F
K
V
V
E
K
KTKP
Y
I
Q
------------------------
V
---------------------------
D
----------------------------
I
G
--------------
G
G
Q
T
---------
K
T
------------
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
------
E
------
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
F
F
--
N
-
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
71.61
48%
-69
- C1 -
3LDP
1
GRP78_HUMAN
B:
[7-383]
-----
V
V
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
K
N
G
R
V
E
I
I
A
N
D
Q
G
N
R
I
T
P
S
Y
V
A
F
-
T
P-
E
G
E
R
L
I
G
D
A
A
K
N
Q
L
T
S
N
P
E---------------
N
-
T
V
F
--------------
D
--------------
A
K
R
----------------------------
L
I
----------
G
-------------------
R
T
---------------
W
NDPSVQQDIKFLPFKVVEKKTKPYI
Q
------------------------
V
---------------------------
D
----------------------------
I
G
--------------
G
GQT---------
K
T
------------
F
A
--
P
E
E
I
S
A
M
V
L
T
K
M
K
E
T
A
E
A
Y
L
G
K
K
V
T
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
T
I
A
G
L
N
V
M
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
R
------
E
------
G
E
K
N
-
I
L
V
F
D
L
G
G
G
T
F
D
V
S
L
L
T
I
----
D
N
G
V
F
E
V
V
-
A
T
N
G
D
T
H
L
G
G
E
D
F
D
Q
R
V
M
E
H
F
I
K
L
Y
K
K
K
T
-
G
K
D
V
R
K
D
N
R
A
V
Q
K
L
R
R
E
V
E
K
A
K
R
A
L
S
S
Q
-
H
Q
A
R
I
E
I
E
S
F
Y
E
G
E
----
D
F
S
E
T
L
T
R
A
K
F
E
E
L
N
M
D
L
F
-
R
S
T
M
K
P
V
Q
K
V
L
E
D
S
D
L
K
K
S
D
I
D
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
Q
L
V
K
-
E
F
F
--
N
-
G
-
K
E
P
S
R
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
71.20
47%
-73
- C1 -
3GDQ
3
HS71L_HUMAN
A:
[31-406]
------
I
G
I
D
L
G
T
T
Y
S
C
V
G
V
F
Q
H
G
K
V
E
I
I
A
N
D
Q
G
N
R
T
T
P
S
Y
V
A
F
-
T
--
D
T
E
R
L
I
G
D
A
A
K
N
Q
V
A
M
N
P
QNTVFDAKRLIGRKFN
D
-
P
V
V
--------------
Q
--------------
A
D
M
----------------------------
K
L
----------
W
-------------------
P
F
---------------
Q
-------------------------
V
------------------------
I
---------------------------
N
----------------------------
E
G
--------------
G
------------
K
P
K
V
L
V
S
Y
KG
E
N
K
A
F
Y
--
P
E
E
I
S
S
M
V
L
T
K
L
K
E
T
A
E
A
F
L
G
H
P
V
T
N
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
V
I
A
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
A
Y
G
L
D
--
K
---
G
---------------
E
R
H
V
L
I
F
D
L
G
G
G
T
F
D
V
S
I
L
T
I
----
D
D
G
I
F
E
V
K
-
A
T
A
G
D
T
H
L
G
G
E
D
F
D
N
R
L
V
S
H
F
V
E
E
F
K
R
K
H
-
K
K
D
I
S
Q
N
K
R
A
V
R
R
L
R
T
A
C
E
R
A
K
R
T
L
S
S
S
-
T
Q
A
N
L
E
I
D
S
L
Y
E
G
----
I
D
F
Y
T
S
I
T
R
A
R
F
E
E
L
C
A
D
L
F
-
R
G
T
L
E
P
V
E
K
A
L
R
D
A
K
M
D
K
A
K
I
H
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
R
L
L
Q
D
Y
-
F
--
N
-
G
-
R
D
L
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
M
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------