@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0099: (2015-11-28 )
MTRYKAQISYDGSAFSGFQRQPNCRTVQEEIERTLKRLNSGNDVIIHGAGRTDAGVHAYGQVIHFDLPQARDVEKLRFGLDTQCPDDIDIVKVEQVSDDFHCRYDKHIKTYEFLVDIGRPKNPMMRNYATHYPYPVIIELMQEAIKDLVGTHDFTGFTASGTSVENKVRTIFDAKIQFEASKNLLIFTFTGNGFLYKQVRNMVGTLLKIGNGRMPISQIKTILQAKNRDLAGPTAAGNGLYLKEIIYEDKECFSNFRK
Atome Classification :
(20 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------........------------.10........-.20..-.......30......-.-----.40..-----.---.....50........60----...---------....--.-----70---..-......80.....--...-------------90......----..-100..---..--..-----.110.......120.....-----.--.130.-......140........---150..-.-....160----........------------170.......---.180-..--...----...190-....---------.....200.......210...----......220..--------.---------...--.230....-------...240-.......250......-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MT
R
Y
K
A
Q
I
------------
S
Y-DGSAFSGF-QR-QP-NC
R
T
V
Q
E
E
I
E
R
T
L
K
R
-L-----NSGN
D
-----
V
---
I
I
HGAGRTD
A
G
V
H
A
Y
G
Q
----
V
I
H
---------FDLP--Q-----AR---
D
V
-
E
K
L
R
FGLDTQCPD--DI
D
-------------
I
V
K
V
EQVS----DD-FHC
R
Y
---
D
K--HI-----
K
T
Y
E
F
L
V
DIGRPKNP
M
M
R
N-----Y--ATHY
P
-
Y
P
V
I
I
E
L
M
-
Q
E
A
I
K
D
L
V
---GTHDF-T-GFTAS-G----T
S
V
E
N
K
V
R
------------
T
I
-
F
D
A
K
I
Q
F
---EAS--K
N
--
L
L
I
----
F
T
FT---GN
G
F
---------
L
Y
K
Q
V
R
N
M
V
G
T
L
L
K
IG--NGR----M
P
I
S
Q
I
K
T
I
L
Q
--------A---------KNR--DLAGPTAA-------GN
G
L
Y
L
-
K
E
I
I
YE
D
K
E
C
F
S
N
FRK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Fugue
96.95
32%
-98
* C5 *
1DJ0
1
TRUA_ECOLI
A:
[1-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P
P
V
Y
K
I
A
L
G
I
------------
E
Y
-
D
G
S
K
Y
Y
G
W
-
Q
R
-
Q
N
-
E
V
R
S
V
Q
E
K
L
E
K
A
L
S
Q
-
V
-----
A
-
N
E
P
-----
I
---
T
V
F
C
A
G
R
T
D
A
G
V
H
G
T
G
Q
----
V
V
H
---------
F
E
T
T
--
A
-----
L
R
---
K
D
-
A
A
W
T
L
G
V
N
A
N
L
P
G
--
D
I
A
-------------
V
R
W
V
K
T
V
P
----
D
D
-
F
H
A
R
F
---
S
A
--
T
A
-----
R
R
Y
R
Y
I
I
Y
N
H
R
L
R
P
A
V
L
S
K
-----
G
--
V
T
H
F
Y
-
E
P
L
D
A
E
R
M
-
H
R
A
A
Q
C
L
L
---
G
E
N
D
F
-
T
-
S
F
R
A
V
-
Q
----
C
Q
S
R
T
P
W
R
------------
N
V
-
M
H
I
N
V
T
R
---
H
----
G
P
--
Y
V
V
----
V
D
I
K
---
A
N
A
F
---------
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
--
A
H
N
----
Q
P
E
S
W
I
A
E
L
L
A
--------
A
---------
K
D
R
--
T
L
A
A
A
T
A
K
-------
A
E
G
L
Y
L
-
V
A
V
D
Y
P
D
R
Y
D
L
P
K
P
P
M
GPLFLAD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
96.39
33%
-103
- C5 -
1DJ0
1
TRUA_ECOLI
A:
[3-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
K
I
A
L
G
I
------------
E
Y
-
D
G
S
K
Y
Y
G
W
-
Q
R
-
Q
N
-
E
V
R
S
V
Q
E
K
L
E
K
A
L
S
Q
-
V
-----
A
N
-
E
P
-----
I
---
T
V
F
C
A
G
R
T
D
A
G
V
H
G
T
G
Q
----
V
V
H
---------
F
E
T
T
--
A
-----
L
R
---
K
D
-
A
A
W
T
L
G
V
N
A
N
L
P
G
--
D
I
A
-------------
V
R
W
V
K
T
V
P
----
D
D
-
F
H
A
R
F
---
S
A
--
T
A
-----
R
R
Y
R
Y
I
I
Y
N
H
R
L
R
P
A
V
L
S
K
-----
G
--
V
T
H
F
Y
-
E
P
L
D
A
E
R
M
-
H
R
A
A
Q
C
L
L
---
G
E
N
D
F
-
T
-
S
F
R
A
V
-
Q
----
C
Q
S
R
T
P
W
R
------------
N
V
-
M
H
I
N
V
T
R
---
H
----
G
P
--
Y
V
V
----
V
D
I
K
---
A
N
A
F
---------
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
--
A
H
N
----
Q
P
E
S
W
I
A
E
L
L
A
--------
A
---------
K
D
R
--
T
L
A
A
A
T
A
K
-------
A
E
G
L
Y
L
-
V
A
V
D
Y
P
D
R
Y
D
L
P
K
P
P
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.71
37%
-97
- C5 -
1VS3
-
TRUA_THET8
A:
[1-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
R
L
L
L
L
C
------------
E
Y
-
D
G
T
L
F
A
G
L
-
Q
R
-
Q
G
R
G
L
R
T
V
Q
G
E
L
E
R
A
L
P
G
-
I
-----
G
A
L
P
K
-----
A
---
V
--
A
A
G
R
T
D
A
G
V
H
A
L
A
M
----
P
F
H
---------
V
D
V
E
--
S
-----
A
I
---
P
V
-
E
K
V
P
E
A
L
N
R
L
L
P
E
--
D
L
K
-------------
V
V
G
A
R
E
V
A
----
P
D
-
F
H
A
R
K
---
D
A
--
L
W
-----
R
A
Y
R
Y
R
I
L
V
R
P
H
P
S
P
L
L
R
H
-----
R
--
A
L
W
V
R
-
R
P
L
D
L
E
A
M
-
E
E
A
L
S
L
L
L
---
G
R
H
N
F
-
L
-
G
F
A
K
E
-
E
----
T
R
P
G
E
--
R
------------
E
L
-
L
E
A
R
L
Q
V
A
EG
E
A
G
--
L
E
--
V
R
L
----
Y
-
F
R
---
G
K
S
F
---------
L
R
G
Q
V
R
G
M
V
G
T
L
L
E
V
G
--
L
G
K
----
R
P
P
E
S
L
K
A
I
L
K
--------
T
---------
A
D
R
--
R
L
A
G
P
T
A
P
-------
A
H
G
L
Y
F
-
V
E
A
A
Y
P
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
95.04
38%
-92
- C5 -
1VS3
-
TRUA_THET8
A:
[1-248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
R
L
L
L
L
C
------------
E
Y
-
D
G
T
L
F
A
G
L
-
Q
R
-
Q
G
R
G
L
R
T
V
Q
G
E
L
E
R
A
L
P
G
-
I
-----
G
A
--
L
-----
P
---
K
A
V
A
A
G
R
T
D
A
G
V
H
A
L
A
M
----
P
F
H
---------
V
D
V
E
--
S
-----
A
I
---
P
V
-
E
K
V
P
E
A
L
N
R
L
L
P
E
--
D
L
K
-------------
V
V
G
A
R
E
V
A
----
P
D
-
F
H
A
R
K
---
D
A
--
L
W
-----
R
A
Y
R
Y
R
I
L
V
R
P
H
P
S
P
L
L
R
H
-----
R
--
A
L
W
V
R
-
R
P
L
D
L
E
A
M
-
E
E
A
L
S
L
L
L
---
G
R
H
N
F
-
L
-
G
F
A
K
E
-
E
----
T
--
R
P
G
E
R
------------
E
L
-
L
E
A
R
L
Q
V
---
A
E
G
EA
G
L
--
E
V
R
----
L
Y
F
R
---
G
K
S
F
---------
L
R
G
Q
V
R
G
M
V
G
T
L
L
E
V
G
--
L
G
K
----
R
P
P
E
S
L
K
A
I
L
K
--------
T
---------
A
D
R
--
R
L
A
G
P
T
A
P
-------
A
H
G
L
Y
F
-
V
E
A
A
Y
P
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
93.43
34%
-95
- C5 -
2NQP
1
TRUA_ECOLI
C:
[16-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------------
E
Y
-
D
G
S
K
Y
Y
G
W
-
Q
R
-
Q
N
-
E
V
R
S
V
Q
E
K
L
E
K
A
L
S
Q
-
V
------
A
N
E
P
-----
I
---
T
V
F
C
A
G
R
T
D
A
G
V
H
G
T
G
Q
----
V
V
H
---------
F
E
T
T
--
A
-----
L
R
---
K
D
-
A
A
W
T
L
G
V
N
A
N
L
P
G
--
D
I
A
-------------
V
R
W
V
K
T
V
P
----
D
D
-
F
H
A
R
F
---
S
A
--
T
A
-----
R
R
Y
R
Y
I
I
Y
N
H
R
L
R
P
A
V
L
S
K
-----
G
--
V
T
H
F
Y
-
E
P
L
D
A
E
R
M
-
H
R
A
A
Q
C
L
L
---
G
E
N
D
F
-
T
-
S
F
R
A
---------
V
Q
C
Q
S
R
------------
T
P
-
W
R
N
V
M
H
I
---
N
V
T
--
R
H
GP
Y
V
V
----
V
D
I
K
---
A
N
A
F
---------
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
--
A
H
N
----
Q
P
E
S
W
I
A
E
L
L
A
--------
A
---------
K
D
R
--
T
L
A
A
A
T
A
K
-------
A
E
G
L
Y
L
-
V
A
V
D
Y
P
D
R
Y
D
L
P
K
P
P
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
93.01
34%
-99
- C5 -
1DJ0
1
TRUA_ECOLI
A:
[10-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------------
E
Y
-
D
G
S
K
Y
Y
G
W
-
Q
R
-
Q
N
-
E
V
R
S
V
Q
E
K
L
E
K
A
L
S
Q
-
V
------
A
N
E
P
-----
I
---
T
V
F
C
A
G
R
T
D
A
G
V
H
G
T
G
Q
----
V
V
H
---------
F
E
T
T
--
A
-----
L
R
---
K
D
-
A
A
W
T
L
G
V
N
A
N
L
P
G
--
D
I
A
-------------
V
R
W
V
K
T
V
P
----
D
D
-
F
H
A
R
F
---
S
A
--
T
A
-----
R
R
Y
R
Y
I
I
Y
N
H
R
L
R
P
A
V
L
S
K
-----
G
--
V
T
H
F
Y
-
E
P
L
D
A
E
R
M
-
H
R
A
A
Q
C
L
L
---
G
E
N
D
F
-
T
-
S
F
R
A
---------
V
Q
C
Q
S
R
------------
T
P
-
W
R
N
V
M
H
I
---
N
V
T
--
R
H
GP
Y
V
V
----
V
D
I
K
---
A
N
A
F
---------
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
--
A
H
N
----
Q
P
E
S
W
I
A
E
L
L
A
--------
A
---------
K
D
R
--
T
L
A
A
A
T
A
K
-------
A
E
G
L
Y
L
-
V
A
V
D
Y
P
D
R
Y
D
L
P
K
P
P
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.96
34%
-94
- C5 -
2NQP
-
TRUA_ECOLI
A:
[16-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------------
E
Y
-
D
G
S
K
Y
Y
G
W
-
Q
R
-
Q
N
-
E
V
R
S
V
Q
E
K
L
E
K
A
L
S
Q
-
V
------
A
N
E
P
-----
I
---
T
V
F
C
A
G
R
T
D
A
G
V
H
G
T
G
Q
----
V
V
H
---------
F
E
T
T
--
A
-----
L
R
---
K
D
-
A
A
W
T
L
G
V
N
A
N
L
P
G
--
D
I
A
-------------
V
R
W
V
K
T
V
P
----
D
D
-
F
H
A
R
F
---
S
A
--
T
A
-----
R
R
Y
R
Y
I
I
Y
N
H
R
L
R
P
A
V
L
S
K
-----
G
--
V
T
H
F
Y
-
E
P
L
D
A
E
R
M
-
H
R
A
A
Q
C
L
L
---
G
E
N
D
F
-
T
-
S
F
R
A
---------
V
Q
C
Q
S
R
------------
T
P
-
W
R
N
V
M
H
I
---
N
V
T
--
R
H
GP
Y
V
V
----
V
D
I
K
---
A
N
A
F
---------
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
--
A
H
N
----
Q
P
E
S
W
I
A
E
L
L
A
--------
A
---------
K
D
R
--
T
L
A
A
A
T
A
K
-------
A
E
G
L
Y
L
-
V
A
V
D
Y
P
D
R
Y
D
L
P
K
P
P
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
92.94
34%
-97
- C5 -
1DJ0
1
TRUA_ECOLI
B:
[10-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------------
E
Y
-
D
G
S
K
Y
Y
G
W
-
Q
R
-
Q
N
-
E
V
R
S
V
Q
E
K
L
E
K
A
L
S
Q
-
V
------
A
N
E
P
-----
I
---
T
V
F
C
A
G
R
T
D
A
G
V
H
G
T
G
Q
----
V
V
H
---------
F
E
T
T
--
A
-----
L
R
---
K
D
-
A
A
W
T
L
G
V
N
A
N
L
P
G
--
D
I
A
-------------
V
R
W
V
K
T
V
P
----
D
D
-
F
H
A
R
F
---
S
A
--
T
A
-----
R
R
Y
R
Y
I
I
Y
N
H
R
L
R
P
A
V
L
S
K
-----
G
--
V
T
H
F
Y
-
E
P
L
D
A
E
R
M
-
H
R
A
A
Q
C
L
L
---
G
E
N
D
F
-
T
-
S
F
R
A
---------
V
Q
C
Q
S
R
------------
T
P
-
W
R
N
V
M
H
I
---
N
V
T
--
R
H
GP
Y
V
V
----
V
D
I
K
---
A
N
A
F
---------
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
--
A
H
N
----
Q
P
E
S
W
I
A
E
L
L
A
--------
A
---------
K
D
R
--
T
L
A
A
A
T
A
K
-------
A
E
G
L
Y
L
-
V
A
V
D
Y
P
D
R
Y
D
L
P
K
P
P
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.53
34%
-97
- C5 -
2NR0
-
TRUA_ECOLI
A:
[16-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------------
E
Y
-
D
G
S
K
Y
Y
G
W
-
Q
R
-
Q
N
-
E
V
R
S
V
Q
E
K
L
E
K
A
L
S
Q
-
V
------
A
N
E
P
-----
I
---
T
V
F
C
A
G
R
T
D
A
G
V
H
G
T
G
Q
----
V
V
H
---------
F
E
T
T
--
A
-----
L
R
---
K
D
-
A
A
W
T
L
G
V
N
A
N
L
P
G
--
D
I
A
-------------
V
R
W
V
K
T
V
P
----
D
D
-
F
H
A
R
F
---
S
A
--
T
A
-----
R
R
Y
R
Y
I
I
Y
N
H
R
L
R
P
A
V
L
S
K
-----
G
--
V
T
H
F
Y
-
E
P
L
D
A
E
R
M
-
H
R
A
A
Q
C
L
L
---
G
E
N
D
F
-
T
-
S
F
R
A
---------
V
Q
C
Q
S
R
------------
T
P
-
W
R
N
V
M
H
I
---
N
V
T
--
R
H
GP
Y
V
V
----
V
D
I
K
---
A
N
A
F
---------
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
--
A
H
N
----
Q
P
E
S
W
I
A
E
L
L
A
--------
A
---------
K
D
R
--
T
L
A
A
A
T
A
K
-------
A
E
G
L
Y
L
-
V
A
V
D
Y
P
D
R
Y
D
L
P
K
P
P
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.02
34%
-93
- C5 -
2NRE
-
TRUA_ECOLI
A:
[16-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
------------
E
Y
-
D
G
S
K
Y
Y
G
W
-
Q
R
-
Q
N
-
E
V
R
S
V
Q
E
K
L
E
K
A
L
S
Q
-
V
------
A
N
E
P
-----
I
---
T
V
F
C
A
G
R
T
D
A
G
V
H
G
T
G
Q
----
V
V
H
---------
F
E
T
T
--
A
-----
L
R
---
K
D
-
A
A
W
T
L
G
V
N
A
N
L
P
G
--
D
I
A
-------------
V
R
W
V
K
T
V
P
----
D
D
-
F
H
A
R
F
---
S
A
--
T
A
-----
R
R
Y
R
Y
I
I
Y
N
H
R
L
R
P
A
V
L
S
K
-----
G
--
V
T
H
F
Y
-
E
P
L
D
A
E
R
M
-
H
R
A
A
Q
C
L
L
---
G
E
N
D
F
-
T
-
S
F
R
A
---------
V
-----------------
T
P
-
W
R
N
V
M
H
I
---
N
V
T
--
R
H
GP
Y
V
V
----
V
D
I
K
---
A
N
A
F
---------
V
H
H
M
V
R
N
I
V
G
S
L
M
E
V
G
--
A
H
N
----
Q
P
E
S
W
I
A
E
L
L
A
--------
A
---------
K
D
R
--
T
L
A
A
A
T
A
K
-------
A
E
G
L
Y
L
-
V
A
V
D
Y
P
D
R
Y
D
L
P
K
P
P
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.00
25%
-82
- C5 -
4IQM
-
TRUA_HUMAN
A:
[18-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------------
A
Y
-
S
G
K
G
Y
H
G
M
-
Q
R
N----
F
K
T
I
E
D
D
L
V
S
A
L
V
R
-
S
GCIP
E
N
H
G
E
D
-----
M
RKM
S
F
Q
R
C
A
R
T
D
K
G
V
S
A
A
G
Q
----
V
V
S
---------
L
K
V
W
--
L
-----
I
D
---
D
I
L
E
K
I
----
N
S
H
L
P
S
--
H
I
R
-------------
I
L
G
L
K
R
V
T
----
G
G
-
F
N
S
K
N
---
R
C
--
D
A
-----
R
T
Y
C
Y
L
L
----
P
T
F
A
F
A
H
K
-----
D
RD
V
Q
D
E
T
-
Y
R
L
S
A
E
T
L
-
Q
Q
V
N
R
L
L
A
C
Y
K
G
T
H
N
F
-
H
-
N
F
T
S
Q
K
G
----
P
Q
D
P
S
A
C
R
------------
Y
I
-
L
E
M
Y
C
E
E
---
P
F
V
--
R
E
--
G
L
E
----
F
A
V
I
R
V
K
G
Q
S
F
---------
M
M
H
Q
I
R
K
M
V
G
L
V
V
A
I
V
--
K
G
Y
----
A
P
E
S
V
L
E
R
S
W
G
--------
T
---------
E
K
V
--
D
V
--
P
K
A
P
-------
G
L
G
L
V
L
-
E
R
V
H
F
E
K
Y
N
Q
P
L
D
W
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.67
25%
-86
- C5 -
4NZ6
3
TRUA_HUMAN
A:
[9-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------------
A
Y
-
S
G
K
G
Y
H
G
M
-
Q
R
----
Q
F
K
T
I
E
D
D
L
V
S
A
L
V
R
-
S
GCIP
E
N
H
G
E
D
-----
M
RKM
S
F
Q
R
C
A
R
T
D
K
G
V
S
A
A
G
Q
----
V
V
S
---------
L
K
V
W
--
L
-----
I
D
---
D
I
L
E
K
I
----
N
S
H
L
P
S
--
H
I
R
-------------
I
L
G
L
K
R
V
T
----
G
G
-
F
N
S
K
N
---
R
C
--
D
A
-----
R
T
Y
C
Y
L
L
----
P
T
F
A
F
A
H
K
-----
D
RD
V
Q
D
E
T
-
Y
R
L
S
A
E
T
L
-
Q
Q
V
N
R
L
L
A
C
Y
K
G
T
H
N
F
-
H
-
N
F
T
S
Q
K
G
----
P
Q
D
P
S
A
C
R
------------
Y
I
-
L
E
M
Y
C
E
E
---
P
F
V
--
R
E
--
G
L
E
----
F
A
V
I
R
V
K
G
Q
S
F
---------
M
M
H
Q
I
R
K
M
V
G
L
V
V
A
I
V
--
K
G
Y
----
A
P
E
S
V
L
E
R
S
W
G
--------
T
---------
E
K
V
--
D
V
--
P
K
A
P
-------
G
L
G
L
V
L
-
E
R
V
H
F
E
K
Y
N
Q
R
F
G
N
L
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.34
24%
-90
- C5 -
4NZ7
2
TRUA_HUMAN
A:
[9-260]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
------------
A
Y
-
S
G
K
G
Y
H
G
M
-
Q
-----
Q
F
K
T
I
E
D
D
L
V
S
A
L
V
R
-
S
GCIP
E
N
H
G
E
D
-----
M
RKM
S
F
Q
R
C
A
R
T
A
K
G
V
S
A
A
G
Q
----
V
V
S
---------
L
K
V
W
--
L
-----
I
D
---
D
I
L
E
K
I
----
N
S
H
L
P
S
--
H
I
R
-------------
I
L
G
L
K
R
V
T
----
G
G
-
F
N
S
K
N
---
R
C
--
D
A
-----
R
T
Y
C
Y
L
L
----
P
T
F
A
F
A
H
K
-----
D
RD
V
Q
D
E
T
-
Y
R
L
S
A
E
T
L
-
Q
Q
V
N
R
L
L
A
C
Y
K
G
T
H
N
F
-
H
-
N
F
T
S
Q
K
G
----
P
Q
D
P
S
A
C
R
------------
Y
I
-
L
E
M
Y
C
E
E
---
P
F
V
--
R
E
--
G
L
E
----
F
A
V
I
R
V
K
G
Q
S
F
---------
M
M
H
Q
I
R
K
M
V
G
L
V
V
A
I
V
--
K
G
Y
----
A
P
E
S
V
L
E
R
S
W
G
--------
T
---------
E
K
V
--
D
V
--
P
K
A
P
-------
G
L
G
L
V
L
-
E
R
V
H
F
E
K
Y
N
Q
R
F
G
L
H
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
59.40
13%
-61
- C5 -
2V9K
8
PUS10_HUMAN
A:
[1-529]
GMFPLTEEN
K
H
V
A
Q
L
L
L
N
T
GTC
P
R
C
I
F
R
F
C
GVDF
H
A
P
Y
K
LP
Y
K
E
L
L
N
E
L
Q
K
F
L
E
TNVCNVCLGILQEFCE
K
D
F
I
K
K
V
C
Q
K
V
E
A
S
GFEFT
S
L
V
F
S
V
S
F
PPQ
L
S
V
R
E
H
A
A
W
L
L
V
K
Q
E
M
G
K
Q
S
L
S
L
G
RDDIVQ
L
K
E
A
Y
K
W
I
T
H
P
L
F
S
E
E
L
G
V
P
I
D
GKSL
F
E
V
S
V
V
F
A
H
PETVE
D
C
H
F
L
A
A
I
CPDCFT
R
M
A
V
M
K
A
L
N
K
IK
E
E
D
F
L
K
Q
F
PCPPNSPKAVCAVL
E
I
E
C
A
H
G
A
V
F
V
A
G
R
Y
N
K
Y
S
R
N
L
------------
P
Q
-
T
P
W
I
I
D
G
E
-
R
K
-
L
E
-
S
--
S
V
E
E
L
I
S
D
H
L
L
A
-
V
-----
F
K
A
E
S
-----
F
---
N
F
S
S
S
G
R
E
D
V
D
V
R
T
L
G
N
G
R
P
F
A
I
E
---------
L
V
N
P
--
H
RVHFT
S
Q
---
E
I
-
K
E
L
Q
Q
K
I
N
N
S
-
S
N
--
K
I
Q
-------------
V
R
D
L
Q
L
V
T
RE
A
I
G
H
-
M
K
E
G
E
---
E
E
--
K
T
-----
K
T
Y
S
A
L
I
W
T
---
N
K
A
I
Q
K
K
-----
D
--
I
E
F
L
N
-
D
I
K
D
L
K
I
D
-
Q
K
T
P
L
R
V
L
---
H
R
R
-----------------
P
L
A
V
R
A
R
------------
V
I
-
H
F
M
E
T
Q
Y
---
V
D
E
--
H
---
H
F
R
----
L
H
L
K
---
T
Q
A
G
---------
T
Y
------
I
K
E
F
V
H
G
D
--
F
G
R
----
T
K
P
N
--------------------------
I
G
--
S
L
M
N
V
T
A
D
-------
I
L
E
L
D
V
-
E
S
V
D
V
D
----
W
P
P
A
L
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
50.73
16%
-67
- C5 -
2V9K
5
PUS10_HUMAN
A:
[317-469]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
E
E
L
I
S
D
H
L
L
A
-
V
-----
F
K
A
E
S
-----
F
---
N
F
S
S
S
G
R
E
D
V
D
V
R
T
L
G
N
----
G
R
P
---------
F
A
I
E
L
V
N
PHRV-
H
F
T
S
Q
E
I
-
K
E
L
Q
Q
K
I
N
N
S
-
S
N
--
K
I
Q
-------------
V
R
D
L
Q
L
V
T
----
R
E
A
I
G
H
M
K
E
G
E
E
E
--
K
T
-----
K
T
Y
S
A
L
I
W
T
N
K
-----------------------
A
I
Q
K
K
D
I
-
E
F
L
N
D
I
K
D
---
L
K
I
D
Q
K
T
P
L
R
V
L
H
-
R
----
R
P
L
A
V
R
A
R
------------
V
I
-
H
F
M
E
T
Q
Y
---
V
D
E
--
H
H
--
F
R
L
----
H
L
K
T
---
Q
A
G
T
---------
Y
I
K
E
F
V
H
G
D
F
G
R
T
K
P
N
--
I
G
S
----
L
M
N
V
T
A
D
I
L
E
L
--------
D
---------
V
E
S
--
V
D
V
D
W
P
P
A
-------
L
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
48.13
12%
-23
* C6 *
1GEH
2
RBL_THEKO
A:
[136-443]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
DGPAFG
I
E
G
V
R
K
M
L
------------
E
I
K-
D
R
P
I
Y
G
V
-
V
P
-
K
P
-
K
V
G
Y
S
P
E
E
F
E
K
L
A
Y
D
L
L
-----
S
N
G
A
D
-----
Y
---
M
K
D
D
E
N
L
T
S
P
W
Y
N
R
F
E
E
----
R
A
E
---------
I
M
A
K
--
I
-----
I
D
---
K
V
-
E
N
E
T
G
E
K
K
T
W
F
A
N
IT
A
-
D
-------------
L
L
E
M
E
Q
R
L
----
E
V
-
L
A
D
L
---------------
G
L
K
H
A
M
V
D
V
V
I
T
G
W
G
A
L
R
Y
-----
I
--
R
D
L
A
A
D
Y
G
L
A
I
H
G
H
-
R
A
M
H
A
A
F
T
---
R
N
P
-
Y
-
H
-
G
I
S
M
F
-
V
----
L
A
K
L
Y
R
L
I
GIDQLHVGTAE
G
G
K
-
W
D
V
I
Q
N
A
---
R
I
L
--
R
E
--
S
H
Y
----
K
P
D
E
---
N
D
V
F
---------
H
L
E
Q
K
F
Y
S
I
K
A
A
F
P
T
S
--
S
G
G
----
L
H
P
G
N
I
Q
P
V
I
E
--------
A
L
GTD
I
V
L
Q
L
G
G
G
--
T
L
G
H
P
D
G
P
-------
A
A
G
A
R
A
-
V
R
Q
A
I
D
A
I
M
Q
------GIPLDEYAKTH
K
E
L
A
R
A
L
E
K
WGHVTP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
46.17
15%
-36
- C4 -
4LLG
-
RPOD_ECOLI
F:
[6-612]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QS
Q
L
K
L
L
V
T
R
G
K
E
------------
Q
G
-
Y
L
T
Y
A
E
V
N
-
D
H
-
L
P
-
E
D
I
V
D
S
D
Q
I
E
D
I
I
Q
M
-
I
-----
N
D
M
G
-----------
I
Q
V
M
G
R
T
T
D
P
V
R
M
Y
M
R
----
E
M
G
---------
T
-----
V
-----
E
L
---
L
T
-
R
E
G
E
I
D
I
A
K
R
I
E
D
--
G
I
N
-------------
Q
V
Q
C
S
V
A
E
-----------
Y
---
P
E
--
A
I
-----
T
Y
L
L
E
Q
Y
D
R
V
E
A
E
E
A
R
L
S
D
-----
L
--
I
T
G
F
V
-
D
D
--
P
E
L
A
-
R
E
K
F
A
E
L
R
---
A
Q
Y
V
V
-
T
-
R
D
T
I
K
-
A
----
T
A
Q
E
E
I
L
K
------------
L
S
-
E
V
F
K
-
Q
F
---
R
L
V
--
P
K
--
Q
F
D
----
Y
L
V
N
---
S
M
R
V
---------
M
M
D
R
V
R
T
Q
E
R
L
I
M
K
L
C
VE
Q
C
K
----
M
P
K
K
N
F
I
T
L
F
T
GN------
E
---------
T
S
D
--
T
W
F
N
A
A
I
A
-------
M
N
K
P
W
S
-
E
K
L
H
D
V
S
E
E
V
H
R
A
L
Q
K
L
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I
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E
E
T
GLT
I
E
Q
V
K
D
I
N
R
R
M
S
I
G
E
A
K
A
R
R
A
K
K
E
M
V
E
A
N
L
R
L
V
I
S
I
A
K
K
Y
TNRGLQ
F
L
D
L
I
Q
E
G
N
I
G
L
M
K
A
V
D
K
FEYRRGYK
F
S
T
Y
A
T
W
W
I
R
Q
A
I
T
R
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I
A
D
QART
I
R
I
P
V
H
M
I
E
T
I
N
K
L
N
R
I
S
R
Q
M
LQEMGREPTPEELAERMLMPEDK
I
R
K
V
L
K
IAKEPISMETPIGDDEDSHLGDFIEDTTLEL
P
L
D
S
A
T
T
E
S
L
R
A
A
T
H
D
V
L
A
G
LT
A
R
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A
K
V
L
R
M
R
F
GIDMNTDYT
L
E
E
V
G
K
Q
F
DVTR
E
R
I
R
Q
I
E
A
K
A
L
R
K
L
RHP
S
R
S
E
V
L
RSFLD
42
Fugue
46.13
14%
-22
- C6 -
4RHJ
1
?
A:
[19-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHM
F
S
K
F
L
M
N
V
K
G
VTPRGSDWAN
R
L
-
G
P
V
A
L
F
G
Y
G
A
G
-
M
P
-
R
R
A
P
L
L
D
F
F
L
Q
S
P
R
D
-
C
-----
D
H
Y
A
E
-----
L
---
T
I
H
D
K
G
P
I
E
C
P
P
E
T
V
M
F
----
M
P
V
---------
L
N
C
G
--
Q
-----
M
L
---
D
E
-
A
A
---
G
T
E
T
P
T
S
D
--
E
W
Y
-------------
L
G
S
L
E
A
S
T
----
E
L
-
L
E
K
G
Y
---
V
P
--
V
S
V
G
GDG
S
A
T
L
S
M
V
E
A
Y
K
R
L
F
P
S
D
D
I
-----
V
--
I
V
H
F
S
-
A
R
P
S
V
S
D
P
-
R
S
P
L
R
V
L
L
---
D
K
G
L
L
-
K
-
G
V
V
S
V
-
G
NRQV
S
S
E
D
R
K
V
R
------------
K
L
-
H
K
M
F
Y
M
D
---
M
R
D
IR
N
D
--
Y
P
V
----
F
I
S
I
---
D
A
S
V
---------
L
D
P
A
F
A
P
A
V
D
S
P
V
A
G
G
L-
S
T
R
----
D
L
L
H
I
M
N
G
I
R
G
--------
P
---------
K
V
V
G
I
D
V
Y
G
Y
N
P
D
L
D
V
Y
R
KD
N
V
G
L
T
A
-
I
A
L
S
K
I
I
K
E
G
I
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
45.75
13%
-27
- C6 -
1E19
1
CPKA_PYRFU
A:
[2-314]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
R
V
V
I
------------
A
L
-
G
G
N
A
L
Q
Q
R
-
G
Q
-
K
G
-
S
Y
E
E
M
M
D
N
V
R
K
T
A
R
Q
-
I
-----
A
E
I
I
A
R
GYE
V
V
---
I
T
H
G
N
G
P
Q
V
G
S
L
L
L
H
M
D
----
A
G
Q
A
T
YG
I
P
A
Q
P
M
D
V
A
--
G
-----
A
M
---
S
Q
-
G
W
I
G
Y
M
I
Q
Q
A
L
K
N
--
E
L
R
K
R
G
M
E
K
K
V
V
T
I
I
T
Q
T
I
V
D
K
N
D
----
P
A
-
F
Q
N
P
T
---
K
P
V
G
P
F
-----
Y
D
E
E
T
A
K
R
L
A
R
E
K
G
W
I
V
K
E
DSGR
G
W
--
R
R
V
V
P
-
S
P
D
P
K
G
H
V
E
A
E
T
I
K
K
L
V
---
E
R
G
V
I
-
V
-
I
A
S
G
G
-
G
GV
P
-
V
I
L
E
D
G
E
I
------------
K
G
-
V
E
A
V
I
D
K
---
D
L
A
--
G
E
--
K
L
A
----
E
E
V
N
---
A
D
I
F
---------
M
I
L
T
D
V
N
G
A
A
L
Y
Y
G
T
E
--
K
E
Q
W
L
R
E
V
K
V
E
E
L
R
K
Y
Y
E
E
GHFKAGS
M
---------
G
P
K
--
V
L
A
A
I
R
F
I
-------
E
W
G
-
G
E
-
R
A
I
I
A
H
L
E
K
A
V
E
A
L
E
G
KT
G
T
Q
V
L
P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
43.91
24%
-52
- C3 -
2X4J
-
?
A:
[16-136]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-
F
T
N
K
I
-
G
----
C
N
V
S
S
P
L
K
------------
H
V
D
I
V
G
E
I
V
E
---
E
A
V
--
Y
N
--
F
L
I
D
AGD
K
M
C
V
---
G
N
K
I
G
V
W
K
V
SRKS
L
Y
A
K
V
P
K
G
I
G
V
T
V
Y
L
A
--
N
G
R
----
V
Q
-
G
R
L
I
D
I
---------------------
G
V
--
Y
E
V
L
V
E
E
V
-------
G
D
I
I
Y
I
H
K
D
L
V
Y
--
A
L
C
W
P
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------