@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0103: (2015-11-28 )
MITLEKFIDHLNVEEVLFTFFTKLISILLLIIAFVIVRQVINYLFEKTVNRSLAFSRQKVARQKTLAKLSHNVLNYTLYFFLFYWILSILGVPISSLLAGAGIAGVAIGLGAQGFLSDVVNGFFILLENQFDVGDIINVGTVSGTVTNVGIRTTQIHDFDGTLHFIPNRNITIVSNKSRSNMRAQIDIPLFVHTNLDQISDIVTKINEEYVSKHPAIVGEPTVFGPTTNANGQFVYRINIFTQNGAQFDIYAEFYKLYQKAILEEGIDLPTYNFSNNHSR
Atome Classification :
(20 SA)
.........10........20........30.......--.40........50.-..-.....60........70........80........90........100......---.110.......120.......130.......140.......150.......160.......170--..--......180..-.-----------....190.......200....--...210......-.220........-230.......240.-.---....-.250.......260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MI
T
L
E
K
F
I
D
HL
N
V
E
E
V
L
F
T
F
F
T
K
L
I
S
I
L
L
L
I
I
A
F
V
I
V
R
--
Q
V
I
N
Y
L
F
E
K
TV
N
R
S
-
L
A
-
F
S
R
Q
K
V
A
R
Q
K
T
L
A
K
L
S
H
N
V
L
N
Y
T
L
Y
F
F
L
F
Y
W
I
L
S
I
L
G
V
P
I
S
S
L
L
AGAG
I
A
G
V
A
I
---GLG
A
Q
G
F
L
S
D
V
V
N
G
F
F
I
L
L
ENQFDVG
D
I
I
N
V
GTVS
G
T
V
T
N
V
G
I
R
T
T
Q
I
HDFD
G
T
L
H
F
IPNR
N
I
---
T
I
--
V
SNKSRSN
M
R
A
-
Q
-----------
I
D
I
P
L
F
V
HT
N
L
D
Q
I
S
D
I
V
T
K
I
--
N
E
E
Y
V
SKHPAIV-GEP-TVFGPTTN-AN
G
Q
F
V
Y
R
I
N
I
F
TQ-N---GAQ
F
-
D
I
Y
A
E
F
Y
K
L
Y
Q
K
A
I
L
EEGIDLPTYNFSNNHSR-
23
HHSearch
89.47
29%
-121
* C4 *
3UDC
-
MSCS_ECOLI
A:
[20-277]
----------------------
F
L
L
D
V
L
K
I
L
I
I
A
F
I
G
I
--
K
F
A
D
F
L
I
Y
R
F
Y
K
L
Y
-
S
K
S
K
I
Q
L
P
Q
R
K
I
D
T
L
T
S
L
T
K
N
A
V
R
Y
I
I
Y
F
L
A
G
A
S
I
L
K
L
F
N
I
D
M
T
S
L
L
A
V
A
G
I
G
S
L
A
I
---
G
F
G
A
Q
N
L
V
K
D
M
I
S
G
F
F
I
I
F
E
D
Q
F
S
V
G
D
Y
V
T
I
N
G
I
S
G
T
V
E
E
I
G
L
R
V
T
K
I
R
G
F
S
D
G
L
H
I
I
P
N
G
E
I
---
K
M
--
V
T
N
L
T
K
D
S
M
M
A
-
V
-----------
V
N
I
A
F
P
I
D
E
D
V
D
K
I
I
E
G
L
Q
E
I
--
C
E
E
V
K
K
S
R
D
D
L
I
-
E
G
P
-
T
V
L
G
I
T
-
D
M
Q
D
S
K
L
V
I
M
V
Y
A
K
T
Q
-
P
---
M
Q
K
W
-
A
V
E
R
D
I
R
Y
R
V
K
K
M
F
D
Q
K
N
I
S
F
P
Y
P
Q
M
D
V
N
F
K
R
-
19
PsiBlast_CBE
88.65
32%
-128
- C4 -
3T9N
1
?
F:
[27-268]
----------------------------
I
L
I
I
A
F
I
G
I
K
FA
D
F
L
I
Y
R
F
Y
K
L
Y
S
K
S
K
I
Q
-
L
P
Q
R
K
I
---
D
T
L
T
S
L
T
K
N
A
V
R
Y
I
I
Y
F
L
A
G
A
S
I
L
K
L
F
N
I
D
M
T
S
L
L
A
V
A
G
I
G
S
L
A
I
---
G
F
G
A
Q
N
L
V
K
D
M
I
S
G
F
F
I
I
F
E
D
Q
F
S
V
G
D
Y
V
T
I
N
G
I
S
G
T
V
E
E
I
G
L
R
V
T
K
I
R
G
F
S
D
G
L
H
I
I
P
N
G
E
I
---
K
M
--
V
T
N
L
T
K
D
S
M
M
A
-
V
-----------
V
N
I
A
F
P
I
D
E
D
V
D
K
I
I
E
G
L
Q
E
I
--
C
E
E
V
K
K
S
R
------
G
P
-
T
V
L
G
I
T
D
M
-
Q
D
S
K
L
V
I
M
V
Y
A
K
T
Q
-
P
---
M
Q
K
W
-
A
V
E
R
D
I
R
Y
R
V
K
K
M
F
D
Q
K
N
I
S
F
P
Y
P
R
T
T
V
I
L
S
E
-
21
PsiBlast_CBE
88.62
32%
-124
- C4 -
3T9N
1
?
C:
[27-268]
----------------------------
I
L
I
I
A
F
I
G
I
K
F
A
D
F
L
I
Y
R
F
Y
K
L
Y
S
K
S
K
I
Q
-
L
P
Q
R
K
I
---
D
T
L
T
S
L
T
K
N
A
V
R
Y
I
I
Y
F
L
A
G
A
S
I
L
K
L
F
N
I
D
M
T
S
L
L
A
V
A
G
I
G
S
L
A
I
---
G
F
G
A
Q
N
L
V
K
D
M
I
S
G
F
F
I
I
F
E
D
Q
F
S
V
G
D
Y
V
T
I
N
G
I
S
G
T
V
E
E
I
G
L
R
V
T
K
I
R
G
F
S
D
G
L
H
I
I
P
N
G
E
I
---
K
M
--
V
T
N
L
T
K
D
S
M
M
A
-
V
-----------
V
N
I
A
F
P
I
D
E
D
V
D
K
I
I
E
G
L
Q
E
I
--
C
E
E
V
K
K
S
R
------
G
P
-
T
V
L
G
I
T
D
M
-
Q
D
S
K
L
V
I
M
V
Y
A
K
T
Q
-
P
---
M
Q
K
W
-
A
V
E
R
D
I
R
Y
R
V
K
K
M
F
D
Q
K
N
I
S
F
P
Y
P
R
T
T
V
I
L
S
E
-
1
PsiBlast_PDB
88.43
31%
-116
- C4 -
3UDC
-
MSCS_ECOLI
A:
[27-278]
----------------------------
I
L
I
I
A
F
I
G
I
K
F
A
D
F
L
I
Y
R
F
Y
K
L
Y
S
K
S
K
I
Q
-
L
P
Q
R
K
I
---
D
T
L
T
S
L
T
K
N
A
V
R
Y
I
I
Y
F
L
A
G
A
S
I
L
K
L
F
N
I
D
M
T
S
L
L
A
V
A
G
I
G
S
L
A
I
---
G
F
G
A
Q
N
L
V
K
D
M
I
S
G
F
F
I
I
F
E
D
Q
F
S
V
G
D
Y
V
T
I
N
G
I
S
G
T
V
E
E
I
G
L
R
V
T
K
I
R
G
F
S
D
G
L
H
I
I
P
N
G
E
I
---
K
M
--
V
T
N
L
T
K
D
S
M
M
A
-
V
-----------
V
N
I
A
F
P
I
D
E
D
V
D
K
I
I
E
G
L
Q
E
I
--
C
E
E
V
K
K
S
R
D
D
L
I
-
E
G
P
-
T
V
L
G
I
T
D
M
-
Q
D
S
K
L
V
I
M
V
Y
A
K
T
Q
-
P
---
M
Q
K
W
-
A
V
E
R
D
I
R
Y
R
V
K
K
M
F
D
Q
K
N
I
S
F
P
Y
P
Q
M
D
V
N
F
K
R
-
18
PsiBlast_CBE
88.41
32%
-126
- C4 -
3T9N
1
?
G:
[27-268]
----------------------------
I
L
I
I
A
F
I
G
I
K
FA
D
F
L
I
Y
R
F
Y
K
L
Y
S
K
S
K
I
Q
-
L
P
Q
R
K
I
---
D
T
L
T
S
L
T
K
N
A
V
R
Y
I
I
Y
F
L
A
G
A
S
I
L
K
L
F
N
I
D
M
T
S
L
L
A
V
A
G
I
G
S
L
A
I
---
G
F
G
A
Q
N
L
V
K
D
M
I
S
G
F
F
I
I
F
E
D
Q
F
S
V
G
D
Y
V
T
I
N
G
I
S
G
T
V
E
E
I
G
L
R
V
T
K
I
R
G
F
S
D
G
L
H
I
I
P
N
G
E
I
---
K
M
--
V
T
N
L
T
K
D
S
M
M
A
-
V
-----------
V
N
I
A
F
P
I
D
E
D
V
D
K
I
I
E
G
L
Q
E
I
--
C
E
E
V
K
K
S
R
------
G
P
-
T
V
L
G
I
T
D
M
-
Q
D
S
K
L
V
I
M
V
Y
A
K
T
Q
-
P
---
M
Q
K
W
-
A
V
E
R
D
I
R
Y
R
V
K
K
M
F
D
Q
K
N
I
S
F
P
Y
P
R
T
T
V
I
L
S
E
-
22
PsiBlast_CBE
88.29
32%
-126
- C4 -
3T9N
2
?
B:
[27-268]
----------------------------
I
L
I
I
A
F
I
G
I
K
F
A
D
F
L
I
Y
R
F
Y
K
L
Y
S
K
S
K
I
Q
-
L
P
Q
R
K
I
---
D
T
L
T
S
L
T
K
N
A
V
R
Y
I
I
Y
F
L
A
G
A
S
I
L
K
L
F
N
I
D
M
T
S
L
L
A
V
A
G
I
G
S
L
A
I
---
G
F
G
A
Q
N
L
V
K
D
M
I
S
G
F
F
I
I
F
E
D
Q
F
S
V
G
D
Y
V
T
I
N
G
I
S
G
T
V
E
E
I
G
L
R
V
T
K
I
R
G
F
S
D
G
L
H
I
I
P
N
G
E
I
---
K
M
--
V
T
N
L
T
K
D
S
M
M
A
-
V
-----------
V
N
I
A
F
P
I
D
E
D
V
D
K
I
I
E
G
L
Q
E
I
--
C
E
E
V
K
K
S
R
------
G
P
-
T
V
L
G
I
T
D
M
-
Q
D
S
K
L
V
I
M
V
Y
A
K
T
Q
-
P
---
M
Q
K
W
-
A
V
E
R
D
I
R
Y
R
V
K
K
M
F
D
Q
K
N
I
S
F
P
Y
P
R
T
T
V
I
L
S
E
-
20
PsiBlast_CBE
88.24
32%
-125
- C4 -
3T9N
1
?
E:
[27-268]
----------------------------
I
L
I
I
A
F
I
G
I
K
FA
D
F
L
I
Y
R
F
Y
K
L
Y
S
K
S
K
I
Q
-
L
P
Q
R
K
I
---
D
T
L
T
S
L
T
K
N
A
V
R
Y
I
I
Y
F
L
A
G
A
S
I
L
K
L
F
N
I
D
M
T
S
L
L
A
V
A
G
I
G
S
L
A
I
---
G
F
G
A
Q
N
L
V
K
D
M
I
S
G
F
F
I
I
F
E
D
Q
F
S
V
G
D
Y
V
T
I
N
G
I
S
G
T
V
E
E
I
G
L
R
V
T
K
I
R
G
F
S
D
G
L
H
I
I
P
N
G
E
I
---
K
M
--
V
T
N
L
T
K
D
S
M
M
A
-
V
-----------
V
N
I
A
F
P
I
D
E
D
V
D
K
I
I
E
G
L
Q
E
I
--
C
E
E
V
K
K
S
R
------
G
P
-
T
V
L
G
I
T
D
M
-
Q
D
S
K
L
V
I
M
V
Y
A
K
T
Q
-
P
---
M
Q
K
W
-
A
V
E
R
D
I
R
Y
R
V
K
K
M
F
D
Q
K
N
I
S
F
P
Y
P
R
T
T
V
I
L
S
E
-
2
PsiBlast_PDB
88.11
32%
-122
- C4 -
3T9N
2
?
A:
[27-268]
----------------------------
I
L
I
I
A
F
I
G
I
K
F
A
D
F
L
I
Y
R
F
Y
K
L
Y
S
K
S
K
I
Q
-
L
P
Q
R
K
I
---
D
T
L
T
S
L
T
K
N
A
V
R
Y
I
I
Y
F
L
A
G
A
S
I
L
K
L
F
N
I
D
M
T
S
L
L
A
V
A
G
I
G
S
L
A
I
---
G
F
G
A
Q
N
L
V
K
D
M
I
S
G
F
F
I
I
F
E
D
Q
F
S
V
G
D
Y
V
T
I
N
G
I
S
G
T
V
E
E
I
G
L
R
V
T
K
I
R
G
F
S
D
G
L
H
I
I
P
N
G
E
I
---
K
M
--
V
T
N
L
T
K
D
S
M
M
A
-
V
-----------
V
N
I
A
F
P
I
D
E
D
V
D
K
I
I
E
G
L
Q
E
I
--
C
E
E
V
K
K
S
R
D
----
E
G
P
-
T
V
L
G
I
T
D
M
-
Q
D
S
K
L
V
I
M
V
Y
A
K
T
Q
-
P
---
M
Q
K
W
-
A
V
E
R
D
I
R
Y
R
V
K
K
M
F
D
Q
K
N
I
S
F
P
Y
P
R
T
T
V
I
L
S
E
-
5
PsiBlast_PDB
82.27
26%
-116
- C4 -
5AJI
2
?
A:
[21-279]
-------------
Q
A
L
L
L
S
Y
A
V
N
I
V
A
A
L
----
A
I
I
I
V
G
--
L
I
I
A
R
M
I
S
N
A
V
N
R
--
L
M
-
I
S
R
K
I
D
A
---
T
V
A
-
F
L
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
T
A
S
V
I
A
V
L
G
A
A
G
L
A
V
---
G
L
A
L
Q
G
S
L
S
N
L
A
A
G
V
L
L
V
M
F
R
P
F
R
A
G
E
Y
V
D
L
G
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
---
I
A
G
N
I
I
N
F
S
R
E
P
V
R
R
N
E
-----------
F
I
I
G
V
A
Y
D
S
D
I
D
Q
V
K
Q
I
L
T
N
I
I
Q
S
E
D
R
I
L
K
D
R
E
M
T
-
V
R
L
-
N
E
L
G
A
S
S
I
----
N
F
V
V
R
--
V
W
S
N
-
S
---
G
D
L
Q
-
N
V
Y
W
D
V
L
E
R
I
K
R
E
F
D
A
A
G
I
S
F
P
Y
P
Q
M
D
V
N
F
K
R
-
7
PsiBlast_PDB
81.85
26%
-119
- C4 -
4AGF
-
MSCS_ECOLI
A:
[25-279]
-----------------
L
S
Y
A
V
N
I
V
A
A
L
A
I
I
I
V
G
L
I
I
A
--
R
M
I
S
----
N
A
V
N
R
--
L
M
-
I
S
R
K
I
D
A
---
T
V
A
D
F
L
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
T
A
S
V
I
A
V
L
G
A
A
G
L
A
V
---
G
L
A
L
Q
G
S
L
S
N
L
A
A
G
V
L
C
V
M
F
R
P
F
R
A
G
E
Y
V
D
L
G
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
---
I
A
G
N
I
I
N
F
S
R
E
P
V
R
R
N
E
-----------
F
I
I
G
V
A
Y
D
S
D
I
D
Q
V
K
Q
I
L
T
N
I
I
Q
S
E
D
R
I
L
K
D
R
E
M
T
-
V
R
L
-
N
E
L
G
A
S
S
I
----
N
F
V
V
R
--
V
W
S
N
-
S
---
G
D
L
Q
-
N
V
Y
W
D
V
L
E
R
I
K
R
E
F
D
A
A
G
I
S
F
P
Y
P
Q
M
D
V
N
F
K
R
-
48
Fugue
81.83
22%
-134
- C4 -
2VV5
-
MSCS_ECOLI
A:
[25-280]
----------------
L
S
Y
A
V
N
I
V
A
A
L
A
I
I
I
V
G
L
I
I
A
R
--
M
I
S
N
A
V
N
R
L
M
I
S
R
K
-
I
----------
D
A
T
V
A
D
F
L
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
T
A
S
V
I
A
V
L
G
A
A
G
L
V
V
---
G
L
A
L
Q
G
S
L
S
N
L
A
A
G
V
L
L
V
M
F
R
P
F
R
A
G
E
Y
V
D
L
G
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
I
A
G
N
I
--
I
N
F
S
R
E
P
V
R
R
N
-
E
-----------
F
I
I
G
V
A
Y
D
S
D
I
D
Q
V
K
Q
I
L
T
N
I
--
I
Q
S
----
E
D
R
I
L
-
K
D
R
E
M
T
V
R
L
N
E
L
-
G
A
S
S
I
N
F
V
V
R
V
W
S
N
-
S
---
G
D
L
Q
-
N
V
Y
W
D
V
L
E
R
I
K
R
E
F
D
A
A
G
I
S
F
P
Y
P
Q
M
D
V
N
F
K
R
V
3
PsiBlast_PDB
81.40
26%
-117
- C4 -
2OAU
-
MSCS_ECOLI
A:
[27-279]
-------------------
Y
A
V
N
I
V
A
A
L
A
I
I
I
V
G
L
I
I
A
--
R
M
I
S
----
N
A
V
N
R
--
L
M
-
I
S
R
K
I
D
A
---
T
V
A
D
F
L
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
T
A
S
V
I
A
V
L
G
A
A
G
L
A
V
---
G
L
A
L
Q
G
S
L
S
N
L
A
A
G
V
L
L
V
M
F
R
P
F
R
A
G
E
Y
V
D
L
G
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
---
I
A
G
N
I
I
N
F
S
R
E
P
V
R
R
N
E
-----------
F
I
I
G
V
A
Y
D
S
D
I
D
Q
V
K
Q
I
L
T
N
I
I
Q
S
E
D
R
I
L
K
D
R
E
M
T
-
V
R
L
-
N
E
L
G
A
S
S
I
----
N
F
V
V
R
--
V
W
S
N
-
S
---
G
D
L
Q
-
N
V
Y
W
D
V
L
E
R
I
K
R
E
F
D
A
A
G
I
S
F
P
Y
P
Q
M
D
V
N
F
K
R
-
6
PsiBlast_PDB
80.71
26%
-114
- C4 -
4AGE
-
MSCS_ECOLI
A:
[25-279]
-----------------
L
S
Y
A
V
N
I
V
A
A
L
----
A
I
I
I
V
G
--
L
I
I
A
R
M
I
S
N
A
V
N
R
--
L
M
-
I
S
R
K
I
D
A
---
T
V
A
C
F
L
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
T
A
S
V
I
A
V
L
G
A
A
G
L
A
V
---
G
L
A
L
Q
G
S
L
S
N
L
A
A
G
V
L
L
V
M
F
R
P
F
R
A
G
E
Y
V
D
L
G
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
---
I
A
G
N
I
I
N
F
S
R
E
P
V
R
R
N
E
-----------
F
I
I
G
V
A
Y
D
S
D
I
D
Q
V
K
Q
I
L
T
N
I
I
Q
S
E
D
R
I
L
K
D
R
E
M
T
-
V
R
L
-
N
E
L
G
A
S
S
I
----
N
F
V
V
R
--
V
W
S
N
-
S
---
G
D
L
Q
-
N
V
Y
W
D
V
L
E
R
I
K
R
E
F
D
A
A
G
I
S
F
P
Y
P
Q
M
D
V
N
F
K
R
-
8
PsiBlast_PDB
80.69
26%
-114
- C4 -
2VV5
-
MSCS_ECOLI
A:
[25-279]
-----------------
L
S
Y
A
V
N
I
V
A
A
L
----
A
I
I
I
V
G
--
L
I
I
A
R
M
I
S
N
A
V
N
R
--
L
M
-
I
S
R
K
I
D
A
---
T
V
A
D
F
L
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
T
A
S
V
I
A
V
L
G
A
A
G
L
V
V
---
G
L
A
L
Q
G
S
L
S
N
L
A
A
G
V
L
L
V
M
F
R
P
F
R
A
G
E
Y
V
D
L
G
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
---
I
A
G
N
I
I
N
F
S
R
E
P
V
R
R
N
E
-----------
F
I
I
G
V
A
Y
D
S
D
I
D
Q
V
K
Q
I
L
T
N
I
I
Q
S
E
D
R
I
L
K
D
R
E
M
T
-
V
R
L
-
N
E
L
G
A
S
S
I
----
N
F
V
V
R
--
V
W
S
N
-
S
---
G
D
L
Q
-
N
V
Y
W
D
V
L
E
R
I
K
R
E
F
D
A
A
G
I
S
F
P
Y
P
Q
M
D
V
N
F
K
R
-
4
PsiBlast_PDB
80.28
26%
-115
- C4 -
4HWA
-
MSCS_ECOLI
A:
[25-279]
-----------------
L
S
Y
A
V
N
I
V
A
A
L
A
I
I
I
V
G
L
I
I
A
--
R
M
I
S
----
N
A
V
N
R
--
L
M
-
I
S
R
K
I
D
A
---
T
V
A
D
F
L
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
T
A
S
V
I
A
V
L
G
A
A
G
L
A
V
---
G
L
A
L
Q
G
S
L
S
N
L
A
A
G
V
L
L
V
M
F
R
P
F
R
A
G
E
Y
V
D
L
G
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
---
I
A
G
N
I
I
N
F
S
R
E
P
V
R
R
N
E
-----------
F
I
I
G
V
A
Y
D
S
D
I
D
Q
V
K
Q
I
L
T
N
I
I
Q
S
E
D
R
I
L
K
D
R
E
M
T
-
V
R
L
-
N
E
L
G
A
S
S
I
----
N
F
V
V
R
--
V
W
S
N
-
S
---
G
D
L
Q
-
N
V
Y
W
D
V
L
E
R
I
K
R
E
F
D
A
A
G
I
S
F
P
Y
P
Q
M
D
V
N
F
K
R
-
9
PsiBlast_PDB
66.37
23%
-87
- C4 -
4HW9
-
?
A:
[75-259]
------------------------------------------------------------------------------------------
L
S
T
L
G
V
Q
T
T
S
I
I
T
V
L
G
T
V
G
I
A
V
---
A
L
A
L
K
D
Y
L
S
S
I
A
G
G
I
I
L
I
I
L
H
P
F
K
K
G
D
I
I
E
I
S
G
L
E
G
K
V
E
A
L
N
F
F
N
T
S
L
R
L
H
D
G
R
L
A
V
L
P
N
R
S
V
---
A
N
--
S
N
I
I
N
S
N
N
T
A
C
-
R
R
I
EWVCGVGYG
S
D
I
E
L
-
V
H
K
T
I
K
D
V
I
D
T
M
E
K
I
--
D
K
N
M
-----------
P
-
T
F
I
G
I
T
D
F
-
G
S
S
S
L
N
F
T
I
R
V
W
A
K
I
E
---
D
G
I
F
-
N
V
R
S
E
L
I
E
R
I
K
N
A
L
D
A
N
H
I
E
I
P
F
N
K
L
D
I
A
I
K
N
-
53
Fugue
58.69
18%
-75
* C5 *
4WW7
7
BUD32_YEAST
A:
[4-257]
------------------
E
F
I
D
K
V
S
S
Y
L
T
P
D
V
D
I
A
P
I
S
--
Q
G
A
A
I
V
F
T
T
T
T
H
P
Y
-
L
---
P
R
A
K
D
S
H
Q
K
Y
I
I
K
Y
R
P
R
T
L
N
E
S
R
L
L
A
K
L
Y
L
I
P
G
L
C
V
P
Q
L
I
A
C
D
P
Y
N
G
F
I
W
L
E
F
LGE
D
L
P
G
G
H
G
F
S
N
L
K
N
F
L
W
M
H
D
Q
D
P
Y
S
-------
D
L
V
A
T
T
L
R
K
V
G
R
Q
I
G
L
L
H
W
N
D
Y
C
H
G
D
L
T
S
S
N
I
---
V
L
--
V
R
D
G
A
-------------------
R
W
T
P
H
L
I
D
F
G
L
G
S
V
S
N
L
V
E
D
K
--
G
V
D
L
Y
V
L
E
R
A
I
L
-
S
T
H
-
S
K
H
A
E
K
Y
N
-
A
W
I
M
E
G
F
E
E
V
Y
R
E
Q
-
G
---
A
K
G
A
-
K
K
L
K
E
V
T
K
R
F
E
E
V
R
L
R
------------
G
R
K
R
-
12
PsiBlast_PDB
55.50
24%
-78
- C6 -
1OPK
1
ABL1_MOUSE
A:
[90-244]
----------------------------------------------------------------------------------------
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
---
R
N
A
A
E
Y
L
L
S
S
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
----
D
G
K
L
Y
--------------
V
S
S
E
S
R
F
N
T
L
A
-
E
-----------
L
-----
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
------
Y
P
A
P
K
R
N
K
P
-
T
I
Y
G
V
S
P
N
-
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
KLG
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
E
F
L
K
E
-
10
PsiBlast_PDB
55.35
24%
-79
* C6 *
1OPL
1
ABL1_HUMAN
A:
[129-283]
----------------------------------------------------------------------------------------
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
---
R
N
A
A
E
Y
L
L
S
S
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
----
D
G
K
L
Y
--------------
V
S
S
E
S
R
F
N
T
L
A
-
E
-----------
L
-----
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
------
Y
P
A
P
K
R
N
K
P
-
T
V
Y
G
V
S
P
N
-
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
KLG
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
E
F
L
K
E
-
11
PsiBlast_PDB
54.27
24%
-76
- C6 -
2FO0
2
ABL1_HUMAN
A:
[87-241]
----------------------------------------------------------------------------------------
W
V
P
S
N
Y
I
T
P
V
N
S
L
E
K
H
S
W
Y
H
G
P
V
S
---
R
N
A
A
E
Y
L
L
S
S
G
I
N
G
S
F
L
V
R
E
S
E
S
S
P
G
Q
R
S
I
S
L
R
Y
E
G
R
V
Y
H
Y
R
I
N
T
A
S
----
D
G
K
L
Y
--------------
V
S
S
E
S
R
F
N
T
L
A
-
E
-----------
L
-----
V
H
H
H
S
T
V
A
D
G
L
I
T
T
L
--
H
------
Y
P
A
P
K
R
N
K
P
-
T
V
Y
G
V
S
P
N
-
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
-
H
KLG
G
G
Q
Y
G
E
V
Y
E
G
V
W
K
K
Y
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
V
E
E
F
L
K
E
-