@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0106: (2015-11-28 )
MTKYIFVTGGVVSSIGKGIVAASLGRLLKNRGLKVTIQKFDPYINIDPGTMSPYQHGEVYVTDDGAETDLDLGHYERFIDINLNKYSNVTTGKIYSEVLKKERRGEYLGATVQVIPHVTDALKEKIKRAATTTDSDVIITEVGGTVGDIESLPFLEALRQMKADVGSDNVMYIHTTLLPYLKAAGEMKTKPTQHSVKELRGLGIQPNMLVIRTEQPAGQSIKNKLAQFCDVAPEAVIESLDVDHIYQIPLNMQAQNMDQIVCDHLKLETPAADMTEWSAMVDKVMNLEKKVKIALVGKYVELPDAYLSVVEALKHSGYVNDVAIDLKWVNAAEVTEDNIKELVGDADGIIVPGGFGQRGSEGKIEAIRYARENDVPMLGVCLGMQLTCVEFARNVLKLHGANSAELDPKTPFPIIDIMRDQIDIEDMGGTLRLGLYPCKLKAGSRAAAAYNNQEVVQRRHRHRYEFNTKFREQFEAAGFVFSGVSPDNRLMEVVELPEKKFFVAAQYHPELQSRPNHAEELYTAFVTAAVENMK
Atome Classification :
(20 SA)
.-........10........20........30........40........50........60........70........80........90........100.......110.......120....----...130.------......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280..--.--....290.......300.......310.......320.......--330..-----..--.----------..340---.........350.......360.......370.......380.......390.......400.......410.......420.-------......430....-...440-.......450.......460.......470.......480.......490.......500.........510.......520.......530..---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M-
T
K
Y
I
F
VTG
G
V
V
S
S
I
G
K
G
I
V
A
A
S
L
G
R
L
L
K
NRG
L
K
V
T
I
Q
KFD
P
Y
I
N
IDPGTMSPYQHG
E
V
Y
V
TDDGAETDLDLGH
Y
E
R
F
I
D
I
NLNKYSNVT
T
G
K
I
Y
S
E
V
L
K
K
E
RRGEYLG
A
T
V
Q
V
I
P
H
V
T
D
A
L
K
E
K
I
----
K
R
AATTT------DS
D
V
I
I
T
EVGGTVGDIES
L
P
F
L
E
A
L
R
Q
M
K
A
DVGSD
N
V
M
Y
I
H
T
T
L
L
P
Y
L
K
AAGEMKTKPT
Q
H
S
V
K
E
L
RGLGIQP
N
M
L
V
I
RTEQPA
G
Q
S
I
K
N
K
L
A
Q
F
CDV
A
P
E
A
V
I
E
SLDVD
H
I
Y
QIPLNMQA
Q
N
M
D
Q
I
V
C
D
H
LKLETPA
A
D
M
T
E
W
S
A
M
V
D
K
V
--
M
--
N
L
E
K
K
V
K
I
A
L
V
G
K
YVEL
P
D
A
Y
L
S
V
V
E
A
L
K
HSGY
V
N
D
V
A
I
D
L
K
WV--
N
A
A
EV-----
T
E
--
D
----------
N
I
K
-----
E
L
VGDAD
G
I
I
VPGGFGQRGSEGKI
E
A
I
R
Y
ARENDVP
M
L
G
V
C
LGM
Q
L
T
C
V
E
F
A
R
N
V
L
K
LHGANSAELDPKTPF
P
I
I
D
I
M
RDQI
D
-------
I
E
DMG
G
T
L
R
L
G
L
Y
-
P
C
K
LKA-GSRAAAAYN
N
Q
E
V
V
Q
R
R
H
R
H
RYEF
N
T
K
F
R
E
Q
F
E
AA
G
F
V
F
SGVSP
D
N
R
L
M
E
V
V
ELPEK
K
--
F
F
V
A
A
QYH
P
E
L
QSRP
N
H
A
E
E
L
Y
T
A
F
V
T
A
A
V
ENMK---
29
PsiBlast_CBE
96.17
50%
-79
- C4 -
2AD5
5
PYRG_ECOLI
B:
[3-541]
--
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
----
L
E
G
G
E
--------
G
H
D
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
P
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
--
D
S
Q
D
V
-----
E
T
--
R
----------
G
V
E
-----
I
L
K
G
-
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
D
ENGNVEV------
T
M
R
L
G
A
Q
-
Q
C
Q
L
V
D
-
D
S
L
V
R
Q
L
Y
N
A
P
T
I
V
E
-
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
G
D
D
Q
L
V
E
I
I
E
V
P
N
H
P
--
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
---
24
PsiBlast_CBE
95.89
51%
-84
- C4 -
4ZDI
1
PYRG_MYCTU
F:
[10-548]
--
T
K
H
L
F
V
S
G
-----
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
LAMA
Q
P
D
A
D
G
N
------
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
AS
D
G
C
E
T
-----
T
S
--
G
----------
A
A
A
-----
A
L
-
G
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
------------------
T
M
R
L
G
S
Y
-
P
A
V
L
E
P
-
D
S
V
V
A
Q
A
Y
Q
T
T
Q
V
S
E
-
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
83
Fugue
95.42
50%
-78
- C4 -
1S1M
14
PYRG_ECOLI
A:
[1-544]
M
T
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
----
L
E
G
G
E
--------
G
H
D
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
P
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
--
D
S
Q
D
V
-----
E
T
--
R
----------
G
V
E
-----
I
L
-
K
G
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
D
-------
E
N
G
N
V
E
T
M
R
L
G
A
Q
-
Q
C
Q
L
V
D
-
D
S
L
V
R
Q
L
Y
N
A
-
P
T
I
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
G
D
D
Q
L
V
E
I
I
E
V
P
N
H
P
--
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
R
Q
A
28
PsiBlast_CBE
95.21
51%
-83
- C4 -
4ZDI
1
PYRG_MYCTU
B:
[10-548]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
Q
P
D
A
D
G
N
------
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
AS
D
G
C
E
T
-----
T
S
--
G
----------
A
A
A
-----
A
L
-
G
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
----------------
G
G
T
M
R
L
G
S
Y
-
P
A
V
L
E
P
-
D
S
V
V
A
Q
A
Y
Q
T
T
Q
V
S
E
-
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
23
PsiBlast_CBE
95.13
51%
-82
- C4 -
4ZDI
1
PYRG_MYCTU
G:
[10-548]
--
T
K
H
L
F
V
S
G
---
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
LAMA
Q
P
D
A
D
G
N
------
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
AS
D
G
C
E
T
-----
T
S
--
G
----------
A
A
A
-----
A
L
-
G
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
------------------
T
M
R
L
G
S
Y
-
P
A
V
L
E
P
-
D
S
V
V
A
Q
A
Y
Q
T
T
Q
V
S
E
-
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
52
HHSearch
95.03
50%
-80
* C4 *
3NVA
-
PYRG_SULSO
A:
[2-534]
P
-
N
K
Y
I
V
V
T
G
G
V
L
S
S
V
G
K
G
T
L
V
A
S
I
G
M
L
L
K
R
R
G
Y
N
V
T
A
V
K
I
D
P
Y
I
N
V
D
A
G
T
M
N
P
Y
M
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
M
D
V
N
M
T
K
Y
N
N
I
T
A
G
K
V
Y
F
E
V
I
K
K
E
R
E
G
K
Y
L
G
Q
T
V
Q
I
I
P
H
V
T
D
Q
I
K
D
M
I
----
R
Y
A
S
K
I
N
------
N
A
E
I
T
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
V
R
Q
L
K
L
E
E
G
E
D
N
V
I
F
V
H
I
A
L
V
E
Y
L
S
V
T
G
E
L
K
T
K
P
L
Q
H
S
V
Q
E
L
R
R
I
G
I
Q
P
D
F
I
V
G
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
E
S
Q
K
L
V
S
K
I
L
S
R
L
K
L
E
D
R
Q
V
D
L
T
D
W
I
S
F
V
N
N
I
--
K
GI
N
S
K
K
T
I
N
I
A
L
V
G
K
Y
T
K
L
K
D
S
Y
I
S
I
K
E
A
I
Y
H
A
S
A
Y
I
G
V
R
P
K
L
I
W
I
--
E
S
T
D
L
-----
E
S
DT
K
----------
N
L
N
-----
E
I
L
G
N
V
N
G
I
I
V
L
P
G
F
G
S
R
G
A
E
G
K
I
K
A
I
K
Y
A
R
E
H
N
I
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
E
A
N
S
T
E
I
N
P
N
T
K
D
P
V
I
T
L
L
D
E
Q
K
N
-------
V
T
Q
L
G
G
T
M
R
L
G
A
Q
-
K
I
I
L
K
E
-
G
T
I
A
Y
Q
L
Y
G
K
-
K
V
V
Y
E
R
H
R
H
R
Y
E
V
N
P
K
Y
V
D
I
L
E
D
A
G
L
V
V
S
G
I
S
E
N
-
G
L
V
E
I
I
E
L
P
S
N
K
--
F
F
V
A
T
Q
A
H
P
E
F
K
S
R
P
T
N
P
S
P
I
Y
L
G
F
I
R
A
V
A
S
------
30
PsiBlast_CBE
94.90
50%
-79
- C4 -
1S1M
16
PYRG_ECOLI
B:
[3-541]
--
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
----
L
E
G
G
E
--------
G
H
D
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
C
P
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
E
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
--
D
S
Q
D
V
-----
E
T
--
R
----------
G
V
E
-----
I
L
K
G
-
L
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
D
ENGNVEV------
T
M
R
L
G
A
Q
-
Q
C
Q
L
V
D
-
D
S
L
V
R
Q
L
Y
N
A
P
T
I
V
E
-
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
E
D
A
G
L
R
V
A
G
R
S
G
D
D
Q
L
V
E
I
I
E
V
P
N
H
P
--
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
---
22
PsiBlast_CBE
94.82
51%
-82
- C4 -
4ZDI
1
PYRG_MYCTU
H:
[10-548]
--
T
K
H
L
F
V
S
G
G
-----
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
LAMA
Q
P
D
A
D
G
N
------
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
AS
D
G
C
E
T
-----
T
S
--
G
----------
A
A
A
-----
A
L
-
G
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
------------------
T
M
R
L
G
S
Y
-
P
A
V
L
E
P
-
D
S
V
V
A
Q
A
Y
Q
T
T
Q
V
S
E
-
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
1
PsiBlast_PDB
94.79
50%
-81
- C4 -
3NVA
-
PYRG_SULSO
A:
[4-532]
---
K
Y
I
V
V
T
G
G
V
L
S
S
V
G
K
G
T
L
V
A
S
I
G
M
L
L
K
R
R
G
Y
N
V
T
A
V
K
I
D
P
Y
I
N
V
D
A
G
T
M
N
P
Y
M
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
M
D
V
N
M
T
K
Y
N
N
I
T
A
G
K
V
Y
F
E
V
I
K
K
E
R
E
G
K
Y
L
G
Q
T
V
Q
I
I
P
H
V
T
D
Q
I
K
D
M
I
----
R
Y
A
S
K
I
N
------
N
A
E
I
T
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
V
R
Q
L
K
L
E
E
G
E
D
N
V
I
F
V
H
I
A
L
V
E
Y
L
S
V
T
G
E
L
K
T
K
P
L
Q
H
S
V
Q
E
L
R
R
I
G
I
Q
P
D
F
I
V
G
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
E
S
Q
K
L
V
S
K
I
L
S
R
L
K
L
E
D
R
Q
V
D
L
T
D
W
I
S
F
V
N
N
I
K
G
I
--
N
S
K
K
T
I
N
I
A
L
V
G
K
Y
T
K
L
K
D
S
Y
I
S
I
K
E
A
I
Y
H
A
S
A
Y
I
G
V
R
P
K
L
I
W
I
--
E
S
T
D
L
-----
E
S
--
D
TK--------
N
L
N
-----
E
I
L
G
N
V
N
G
I
I
V
L
P
G
F
G
S
R
G
A
E
G
K
I
K
A
I
K
Y
A
R
E
H
N
I
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
E
A
N
S
T
E
I
N
P
N
T
K
D
P
V
I
T
L
L
D
E
Q
K
N
-------
V
T
Q
L
G
G
T
M
R
L
G
A
Q
-
K
I
I
L
K
E
-
G
T
I
A
Y
Q
L
Y
-
G
K
K
V
V
Y
E
R
H
R
H
R
Y
E
V
N
P
K
Y
V
D
I
L
E
D
A
G
L
V
V
S
G
I
S
-
E
N
G
L
V
E
I
I
E
L
P
S
N
K
--
F
F
V
A
T
Q
A
H
P
E
F
K
S
R
P
T
N
P
S
P
I
Y
L
G
F
I
R
A
V
A
S
------
3
PsiBlast_PDB
94.78
51%
-82
- C4 -
4ZDI
1
PYRG_MYCTU
A:
[10-548]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
Q
P
D
A
D
G
N
------
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
AS
D
G
C
E
T
-----
T
S
--
G
----------
A
A
A
-----
A
L
-
G
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
-----------------
G
T
M
R
L
G
S
Y
-
P
A
V
L
E
P
-
D
S
V
V
A
Q
A
Y
Q
T
T
Q
V
S
E
-
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
25
PsiBlast_CBE
94.70
51%
-82
- C4 -
4ZDI
1
PYRG_MYCTU
E:
[10-548]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
LAMA
Q
P
D
A
D
G
N
------
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
AS
D
G
C
E
T
-----
T
S
--
G
----------
A
A
A
-----
A
L
-
G
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
------------------
T
M
R
L
G
S
Y
-
P
A
V
L
E
P
-
D
S
V
V
A
Q
A
Y
Q
T
T
Q
V
S
E
-
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
27
PsiBlast_CBE
94.65
51%
-81
- C4 -
4ZDI
1
PYRG_MYCTU
C:
[10-548]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
Q
P
D
A
D
G
N
------
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
AS
D
G
C
E
T
-----
T
S
--
G
----------
A
A
A
-----
A
L
-
G
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
-----------------
G
T
M
R
L
G
S
Y
-
P
A
V
L
E
P
-
D
S
V
V
A
Q
A
Y
Q
T
T
Q
V
S
E
-
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
26
PsiBlast_CBE
94.55
51%
-82
- C4 -
4ZDI
1
PYRG_MYCTU
D:
[10-548]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
LAMA
Q
P
D
A
D
G
N
------
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
AS
D
G
C
E
T
-----
T
S
--
G
----------
A
A
A
-----
A
L
-
G
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
------------------
T
M
R
L
G
S
Y
-
P
A
V
L
E
P
-
D
S
V
V
A
Q
A
Y
Q
T
T
Q
V
S
E
-
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
21
PsiBlast_CBE
94.29
51%
-79
- C4 -
4ZDK
4
PYRG_MYCTU
B:
[9-547]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
LAMA
Q
P
D
A
D
G
N
------
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
AS
D
G
C
E
T
-----
T
S
--
G
----------
A
A
A
-----
A
L
-
G
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
----------------
G
G
T
M
R
L
G
S
Y
-
P
A
V
L
E
P
-
D
S
V
V
A
Q
A
Y
Q
T
T
Q
V
S
E
-
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
4
PsiBlast_PDB
94.06
51%
-79
- C4 -
4ZDJ
4
PYRG_MYCTU
A:
[10-548]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
Q
P
D
A
D
G
N
------
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
AS
D
G
C
E
T
-----
T
S
--
G
----------
A
A
A
-----
A
L
-
G
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
----------------
G
G
T
M
R
L
G
S
Y
-
P
A
V
L
E
P
-
D
S
V
V
A
Q
A
Y
Q
T
T
Q
V
S
E
-
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
2
PsiBlast_PDB
93.62
51%
-80
- C4 -
4ZDK
4
PYRG_MYCTU
A:
[9-547]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
Q
P
D
A
D
G
N
------
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
E
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
AS
D
G
C
E
T
-----
T
S
--
G
----------
A
A
A
-----
A
L
-
G
D
V
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
----------------
G
G
T
M
R
L
G
S
Y
-
P
A
V
L
E
P
-
D
S
V
V
A
Q
A
Y
Q
T
T
Q
V
S
E
-
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
S
G
L
R
F
S
G
T
S
P
D
G
H
L
V
E
F
V
E
Y
P
P
D
R
HP
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
---
31
PsiBlast_CBE
65.07
51%
-95
- C4 -
3IHL
2
PYRG2_HUMAN
B:
[2-273]
---
K
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
I
G
T
I
L
K
S
C
G
L
R
V
T
A
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
N
D
G
G
E
--------------------------------------------
V
Q
V
V
P
H
I
T
D
A
V
Q
E
W
V
----
M
N
Q
A
K
V
P
VDGNKE
E
P
Q
I
C
V
I
E
L
G
G
T
I
G
D
I
E
G
M
P
F
V
E
A
F
R
Q
F
Q
F
K
A
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
L
S
A
T
G
E
Q
K
T
K
P
T
Q
N
S
V
R
A
L
R
G
L
G
L
S
P
D
L
I
V
C
R
S
S
T
P
I
E
M
A
V
K
E
K
I
S
M
F
C
H
V
N
P
E
Q
V
I
C
I
H
D
V
S
S
T
Y
R
V
P
V
L
L
E
E
Q
S
I
V
K
Y
F
K
E
R
L
H
L
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.14
40%
-88
- C4 -
2VKT
-
PYRG2_HUMAN
A:
[297-551]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
C
S
I
A
L
V
G
K
Y
-
K
L
R
D
C
Y
A
S
V
F
K
A
L
E
H
S
A
L
A
I
N
H
K
L
N
L
M
Y
I
--
D
S
I
D
L
E
K
I
T
E
T
E
--
D
----------
P
V
K
F
H
E
A
W
Q
K
L
C
K
A
D
G
I
L
V
P
G
G
F
G
I
R
G
T
L
G
K
L
Q
A
I
S
W
A
R
T
K
K
I
P
F
L
G
V
C
L
G
M
Q
L
A
V
I
E
F
A
R
N
C
L
N
L
K
D
A
D
S
T
E
F
R
P
N
A
P
V
P
L
V
I
D
M
P
E
H
---------------
T
M
R
L
G
I
R
-
R
T
V
F
K
T
E
N
S
I
L
R
K
L
Y
G
D
V
P
F
I
E
E
R
H
R
H
R
F
E
V
N
P
N
L
I
K
Q
F
E
Q
N
D
L
S
F
V
G
Q
D
V
D
G
D
R
M
E
I
I
E
L
A
N
H
P
--
Y
F
V
G
V
Q
F
H
P
E
F
S
S
R
P
M
K
P
S
P
P
Y
L
G
L
L
L
A
A
T
G
N
L
----
6
PsiBlast_PDB
61.27
39%
-83
- C4 -
2V4U
-
PYRG2_HUMAN
A:
[297-551]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
C
S
I
A
L
V
G
K
Y
T
K
L
R
D
C
Y
A
S
V
F
K
A
L
E
H
S
A
L
A
I
N
H
K
L
N
L
M
Y
I
--
D
S
I
D
L
E
K
I
T
E
T
E
--
D
----------
P
V
K
F
H
E
A
W
Q
K
L
C
K
A
D
G
I
L
V
P
G
G
F
G
I
R
G
T
L
G
K
L
Q
A
I
S
W
A
R
T
K
K
I
P
F
L
G
V
-
L
G
M
Q
L
A
V
I
E
F
A
R
N
C
L
N
L
K
D
A
D
S
T
E
F
R
P
N
A
P
V
P
L
V
I
D
M
P
E
H
-
N
-------
P
G
N
L
G
G
T
M
R
L
G
I
R
-
R
T
V
F
K
T
E
N
S
I
L
R
K
L
Y
G
D
V
P
F
I
E
E
R
H
R
H
R
F
E
V
N
P
N
L
I
K
Q
F
E
Q
N
D
L
S
F
V
G
Q
D
V
D
G
D
R
M
E
I
I
E
L
A
N
H
P
--
Y
F
V
G
V
Q
F
H
P
E
F
S
S
R
P
M
K
P
S
P
P
Y
L
G
L
L
L
A
A
T
G
N
L
----
56
HHSearch
60.43
39%
-78
- C4 -
2V4U
-
PYRG2_HUMAN
A:
[296-551]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
I
C
S
I
A
L
V
G
K
Y
T
K
L
R
D
C
Y
A
S
V
F
K
A
L
E
H
S
A
L
A
I
N
H
K
L
N
L
M
Y
I
--
D
S
I
D
L
-----
E
K
--
I
T
E
T
E
D
P
V
K
F
H
E
A
W
-----
Q
K
L
C
K
A
D
G
I
L
V
P
G
G
F
G
I
R
G
T
L
G
K
L
Q
A
I
S
W
A
R
T
K
K
I
P
F
L
G
V
-
L
G
M
Q
L
A
V
I
E
F
A
R
N
C
L
N
L
K
D
A
D
S
T
E
F
R
P
N
A
P
V
P
L
V
I
D
M
P
E
H
N
--------
P
G
N
L
G
G
T
M
R
L
G
I
R
R
T
V
F
K
T
E
-
N
S
I
L
R
K
L
Y
G
D
V
P
F
I
E
E
R
H
R
H
R
F
E
V
N
P
N
L
I
K
Q
F
E
Q
N
D
L
S
F
V
G
Q
D
V
D
G
D
R
M
E
I
I
E
L
A
N
H
P
--
Y
F
V
G
V
Q
F
H
P
E
F
S
S
R
P
M
K
P
S
P
P
Y
L
G
L
L
L
A
A
T
G
N
L
----