@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0115: (2015-11-28 )
MKIDMRNISKSFGTNKVLEKIDLELQSGQIHALMGENGAGKSTLMNILTGLFPASTGTIYIDGEERTFSNPQEAEEFGISFIHQEMNTWPEMTVLENLFLGREIKTTFGLLNQKLMRQKALEAFKRLGVTIPLDIPIGNLSVGQQQMIEIAKSLLNQLSILVMDEPTAALTDRETENLFRVIRSLKQEGVGIVYISHRMEEIFKITDFVTVMRDGVIVDTKETSLTNSDELVKKMVGRKLEDYYPEKHSEIGPVAFEVSNLCGDNFEDVSFYVRKGEILGFSGLMGAGRTEVMRTIFGIDKKKSGKVKIDNQEITITSPSQAIKQGIGFLTENRKDEGLILDFNIKDNMTLPSTKDFSKHGFFDEKTRTTFVQQLINRLYIKSGRPDLEVGNLSGGNQQKVVLAKWIGIAPKVLILDEPTRGVDVGAKREIYQLMNELADRGVPIVMVSSDLPEILGVSDRIMVMHEGRISGELSRKEADQEKVMQLATGGK
Atome Classification :
(20 SA)
-------------------------------------------------------------------.........10.--.-.-------.----..--..----20..----..-....30........40........50.....--...--60.-------.----...-------...70----..--.....--.--.80........90---.......-.100----------.....-----...110----------...----..------..120.......130.......140.......150.......160.......170.......180......-.190.......200.......210----...-....220--.......--.---230.....-.------..240------...------------.--.----.---.250.......260----.----.----.....270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......-440.......-.450.......460....-----...470.......480.......490-----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------------MKI
D
M
R
N
I
S
K
SF--G-
T
-------
N
----
K
V
--
L
E
----
K
I
D
L
----
E
L-QS
G
Q
I
H
A
L
MGENGA
G
K
S
T
L
M
N
I
L
T
G
LFPAST--
G
T
I
--
Y
I
D-------G----EER-------TFS
N
-----
P
Q
--
E
A
E
E
F
--
G
--
I
S
F
I
H
Q
E
M
NTWP
E
---
M
T
V
L
E
N
L
-FLG-----------
R
E
I
K
T
-----
T
F
G
L
L
N
----------
Q
K
L
----
M
R
------
Q
K
A
L
E
A
F
K
RLG
V
T
I
P
L
D
IPIGNLSV
G
Q
Q
Q
M
I
E
I
A
K
S
L
L
N
QL
S
I
L
V
MDEPTAALTDR
E
T
E
N
L
F
R
V
I
R
S
L
K
QE-G
V
G
I
V
Y
I
S
H
R
M
E
E
I
F
K
I
T
D
F
V
T
V
M----RD
G
-
V
I
V
DT-K--ETSLT
N
S
--
D
---
E
L
-
V
K
K
M
V-G------
R
K
L
E
D
------YYP------------
E
--
K
----H---SEIG
P
V
A
F
E
V
S
N
LC----G----D----N
F
E
D
V
S
F
Y
V
RKG
E
I
L
GFSGLMGA
G
R
T
E
V
M
R
T
I
FGIDKKKSG
K
V
K
I
DN
Q
E
I
T
IT
S
P
S
Q
A
I
K
Q
G
I
G
F
L
TENRKDE
G
L
I
L
D
F
NIKDNMTLPSTKDFSKHGFFDE
K
T
R
T
T
F
V
Q
Q
L
I
N
R
L
Y
IKSGRPD
L
E
VGNLSGGNQ
Q
K
V
V
L
A
K
WIGIA
P
K
V
L
I
LDEPTRGVDVG
A
K
R
E
I
Y
Q
L
M
N
E
L
A-D-RGV
P
I
V
M
V-SSD
L
P
E
I
LGVS
D
R
I
M
V
M
H-----EGRISGELSRKEA
D
Q
E
K
V
M
Q
L
ATGGK-----------------------------------
17
PsiBlast_PDB
73.37
26%
-111
- C1 -
1JI0
1
?
A:
[7-238]
---------------------------------------------------------------------
L
E
V
Q
S
L
H
V
Y
Y
--
G
-
A
-------
I
----
H
A
--
I
K
----
G
I
D
L
----
K
V
-
P
R
G
Q
I
V
T
L
I
G
A
N
G
A
G
K
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T
T
L
S
A
I
A
G
L
V
R
A
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K
--
G
K
I
--
I
F
N
-------
G
----
Q
D
I
-------
T
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P
-----
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--
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M
--
G
--
I
A
L
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P
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R
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---
L
T
V
Y
E
N
L
-
M
M
G
A
YNRKDK
E
G
I
K
R
D
L
E
W
-----
I
F
S
L
F
--------------------------
P
R
L
K
E
R
L
K
Q
L
G
---------
G
T
L
S
G
G
E
Q
Q
M
L
A
I
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R
A
L
M
S
R
P
K
L
L
M
M
D
E
P
S
L
G
L
A
P
I
L
V
S
E
V
F
E
V
I
Q
K
I
N
Q
E
-
G
T
T
I
L
L
V
E
Q
N
A
L
G
A
L
K
V
A
H
Y
G
Y
V
L
----
E
T
G
Q
I
V
L
E
G
-
K
--
A
S
E
L
L
D
N
--
E
---
M
V
-
R
K
A
Y
L
-
G
------
V
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
63.85
22%
-82
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
-------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
--
H
-
Q
-------
G
TRTI
Q
A
--
L
N
----
N
V
S
L
----
H
V
-
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
--
G
S
V
--
L
V
D
-------
G
----
Q
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L
-------
T
T
L
S
-----
E
S
--
E
L
T
K
A
RR
Q
--
I
G
M
I
F
Q
H
F
N
L
L
S
S
---
R
T
V
F
G
N
V
-
A
L
P
-----------
L
E
L
D
N
-----
T
----
P
----------
K
D
E
----
V
K
------
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
----
S
N
G
-
E
L
I
E
Q
-
D
--
T
--------------------------------------------------------------------------------------------------------------------------
V
S
E
V
F
S
--
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
-
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
-------------------
G
G
V
K
F
G
I
M
L
T
E
M
H
G
------------------
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
-
E
-
H
H
V
K
V
E
V
--------------------------------------------------------------------------------------
36
HHSearch
63.12
23%
-61
- C1 -
1YQT
4
?
A:
[25-479]
------------------------------------------------------------------------
E
D
C
V
H
R
Y
--
G
V
N
-------
A
----
F
V
--
L
Y
----
R
L
P
-----
V
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
CG
D
N
D
--
S
W
D
-------
G
----
V
I
R
A
F
RGNEL
Q
N
Y
F
-----
E
---
K
L
K
N
G
--
E
I
R
P
V
V
K
P
Q
Y
V
D
L
I
P
K
---
A
V
K
G
K
V
I
-
E
L
--------------------------
L
K
----------
K
A
D
----
E
T
------
G
K
L
E
E
V
V
K
A
L
E
L
E
N
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
-
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
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V
----
Y
G
E
-
P
G
V
Y
G
I
F
--
S
Q
P
K
G
T
R
--
N
G
I
N
E
F
-
L
R
G
Y
L
-
K
------
D
E
N
V
R
FRP
Y
E
I
K
F
T
------------
K
--
T
----
G
ERV
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
----
K
D
YGS
F
----
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
I
E
W
D
L
--------------
T
V
A
Y
K
P
Q
Y
I
K
---
A
D
Y
E
G
T
V
Y
E
L
L
S
K
I
D
A
S
K
L
------
N
---
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
-
D
L
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
-
E
K
N
E
K
T
A
L
V
V
-
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
-----
G
E
P
G
K
Y
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
I
-----------------------------------
11
PsiBlast_PDB
62.54
29%
-109
- C1 -
1OXV
7
?
A:
[2-243]
-------------------------------------------------------------------
V
R
I
I
V
K
N
V
S
K
V
F
--
K
-
K
-------
G
----
K
V
VA
L
D
----
N
V
N
I
----
N
I
-
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
--
G
E
L
--
Y
F
D
------------
D
R
L
-------
V
A
S
N
GKLIV
P
P
--
E
D
R
K
I
--
G
--
M
V
F
--
Q
T
W
A
L
Y
P
N
---
L
T
A
F
E
N
I
-------------------------
A
F
P
L
T
N
----------
M
K
M
S
K
E
E
I
R
------
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
----
V
K
G
-
K
L
V
-------------------------
Q
V
-
G
-------
K
P
E
D
------
L
Y
D
---------------------------
N
P
V
S
I
Q
V
A
S
L
I
----
G
----
E
----
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
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L
D
S
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F
T
Y
S
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P
I
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S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
61.84
20%
-63
- C1 -
3OZX
5
?
A:
[5-465]
--------------------------------------------------------------------------
V
I
H
R
Y
--
K
V
N
-------
G
----
F
K
--
L
F
----
G
L
P
T
-----
P
-
K
N
N
T
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
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F
--
G
D
P
--
N
S
K
-------
V
----
G
K
D
-------
E
V
L
K
---------
R
F
R
G
K
--
E
--
I
Y
N
Y
F
K
E
L
Y
S
-
N
E
---
L
K
I
V
H
K
I
-
Q
Y
V
-----------
E
Y
A
S
K
FLKGT
V
N
E
I
L
T
----------
K
I
D
----
E
R
------
G
K
K
D
E
V
K
E
L
L
N
M
T
N
L
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
D
V
Y
I
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P
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S
Y
L
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V
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E
R
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M
A
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A
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-
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D
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Y
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L
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I
----
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--
E
S
S
V
Y
-
G
--
R
V
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K
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Y
A
--
A
---
R
V
G
I
N
N
F
L
K
G
YLP---
A
E
N
M
K
------
I
R
P
------------
D
EI
K
FMLK-------
L
K
T
K
M
K
W
T
K
I
I
K
K
L
G
D
----
F
----
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
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N
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T
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A
R
I
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V
G
E
I
T
A
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E
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S
V
T
P
E
K
Q
-------------
I
L
S
Y
K
P
Q
R
I
F
---
P
N
Y
D
G
T
V
Q
Q
Y
L
E
N
A
S
K
D
A
------
L
--
S
T
S
S
W
F
F
E
E
V
T
K
R
L
N
L
H
-
R
L
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
T
-
R
E
R
K
A
V
T
F
I
I
-
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
K
-----
G
E
P
E
K
A
G
L
A
T
S
P
V
T
L
K
T
G
M
N
E
F
L
R
E
L
-----------------------------------
18
PsiBlast_PDB
61.51
29%
-105
- C1 -
1OXX
22
?
K:
[2-243]
-------------------------------------------------------------------
V
R
I
I
V
K
N
V
S
K
V
F
--
K
-
K
-------
G
----
K
V
VA
L
D
----
N
V
N
I
----
N
I
-
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
--
G
E
L
--
Y
F
D
------------
D
R
L
-------
V
A
S
N
GKLIV
P
P
--
E
D
R
K
I
--
G
--
M
V
F
--
Q
T
W
A
L
Y
P
N
---
L
T
A
F
E
N
I
-------------------------
A
F
P
L
T
N
----------
M
K
M
SKEE
I
R
------
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
----
V
K
G
-
K
L
V
-------------------------
Q
V
-
G
-------
K
P
E
D
------
L
Y
D
---------------------------
N
P
V
S
I
Q
V
A
S
L
I
----
G
----
E
----
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.44
29%
-105
- C1 -
1OXS
19
?
C:
[2-243]
-------------------------------------------------------------------
V
R
I
I
V
K
N
V
S
K
V
F
--
K
-
K
-------
G
----
K
V
VA
L
D
----
N
V
N
I
----
N
I
-
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
--
G
E
L
--
Y
F
D
------------
D
R
L
-------
V
A
S
N
GKLIV
P
P
--
E
D
R
K
I
--
G
--
M
V
F
--
Q
T
W
A
L
Y
P
N
---
L
T
A
F
E
N
I
-------------------------
A
F
P
L
T
N
----------
M
K
M
SKEE
I
R
------
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
----
V
K
G
-
K
L
V
-------------------------
Q
V
-
G
-------
K
P
E
D
------
L
Y
D
---------------------------
N
P
V
S
I
Q
V
A
S
L
I
----
G
----
E
----
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
61.34
24%
-65
- C1 -
3BK7
4
?
A:
[83-547]
--------------------------------------------------------------------
A
I
S
I
V
N
L
P
E
Q
L
--
D
-
E
D
CVHRYG
V
----
N
A
--
F
V
----
L
Y
R
L
----
P
I
V
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
--
C
E
D
ND
S
W
D
N
V
I
R
A
F
R
G
----
N
E
L
-------
Q
N
Y
F
-----
E
R
L
-
K
N
G
E
I
--
R
--
P
V
V
K
P
Q
Y
V
D
L
L
P
K
A
V
K
G
K
V
R
E
L
L
------------------------------
K
----------
K
V
D
----
E
V
------
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
-
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
----
Y
G
E
-
P
G
V
Y
G
-
I
F
S
K
P
K
G
T
R
N
G
I
N
---
E
F
-
L
Q
G
Y
L
-
K
DENVRF
R
P
Y
E
I
------
R
F
T
------------
K
--
L
----
S
ERV
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
----
K
D
YGS
F
----
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
E
W
D
L
--------------
T
V
A
Y
K
P
Q
Y
I
K
---
A
E
Y
E
G
T
V
Y
E
L
L
S
K
I
D
S
S
K
------
L
N
---
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
-
D
L
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
R
L
A
V
S
R
A
I
R
H
L
M
E
K
-
N
E
K
T
A
L
V
V
-
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
-----
G
E
P
G
R
H
G
R
A
L
P
P
M
G
M
R
E
G
M
N
R
F
L
A
S
V
-----------------------------------
3
PsiBlast_PDB
61.21
31%
-104
- C1 -
1GAJ
6
LIVG_METJA
A:
[12-232]
-------------------------------------------------------------------------
N
I
V
K
Y
F
--
G
-
E
-------
F
----
K
A
--
L
D
----
G
V
S
I
----
S
V
-
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
--
G
R
V
--
Y
F
E
-------
N
----
K
D
I
-------
T
N
K
E
-----
P
A
--
E
L
Y
H
Y
--
G
--
I
V
R
T
F
Q
T
P
Q
P
L
K
E
---
M
T
V
L
E
N
L
-
L
I
G
------------
E
I
N
P
-----
G
E
S
P
L
N
S
L
FYKKWIPK
E
E
E
----
M
V
------
E
K
A
F
K
I
L
E
F
L
K
L
S
H
L
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
Q
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
----
F
N
G
-
Q
I
I
A
E
-
G
--
R
G
E
E
E
I
K
--
N
---
V
L
-
S
D
P
K
V
-
V
------
E
I
Y
I
G
------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
60.90
29%
-108
- C1 -
1OXT
-
?
A:
[2-243]
-------------------------------------------------------------------
V
R
I
I
V
K
N
V
S
K
V
F
--
K
-
K
-------
G
----
K
V
VA
L
D
----
N
V
N
I
----
N
I
-
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
--
G
E
L
--
Y
F
D
------------
D
R
L
-------
V
A
S
N
GKLIV
P
P
--
E
D
R
K
I
--
G
--
M
V
F
--
Q
T
W
A
L
Y
P
N
---
L
T
A
F
E
N
I
-------------------------
A
F
P
L
T
N
----------
M
K
M
S
K
E
E
I
R
------
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
----
V
K
G
-
K
L
V
-------------------------
Q
V
-
G
-------
K
P
E
D
------
L
Y
D
---------------------------
N
P
V
S
I
Q
V
A
S
L
I
----
G
----
E
----
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
60.35
33%
-101
- C1 -
4U02
1
?
C:
[5-218]
---------------------------------------------------------------------
I
R
I
R
N
L
H
K
W
F
--
G
-
P
-------
L
----
H
V
--
L
K
----
G
I
H
L
----
E
V
-
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
--
G
E
V
--
V
V
D
-------
G
LSVK
D
D
R
-------
A
L
R
E
-----
I
R
--
R
--
E
V
--
G
--
M
V
F
--
Q
Q
F
N
L
F
P
H
---
M
T
V
L
E
N
V
-
T
L
A
--------------
P
M
-----
R
V
R
R
W
P
----------
R
E
K
----
A
E
------
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
----
D
G
G
-
Q
I
V
E
E
-
G
--
R
P
E
E
I
F
T
--
R
---
P
K
-
E
E
R
T
R
-
S
------
F
L
Q
R
V
------
L
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
60.24
32%
-104
- C1 -
1G6H
3
LIVG_METJA
A:
[12-232]
-------------------------------------------------------------------------
N
I
V
K
Y
F
--
G
-
E
-------
F
----
K
A
--
L
D
----
G
V
S
I
----
S
V
-
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
--
G
R
V
--
Y
F
E
-------
N
----
K
D
I
-------
T
N
K
E
-----
P
A
--
E
L
Y
H
Y
--
G
--
I
V
R
T
F
Q
T
P
Q
P
L
K
E
---
M
T
V
L
E
N
L
-
L
I
G
------------
E
I
C
P
-----
G
E
S
P
L
N
S
L
F
Y
KKWIPK
E
E
E
----
M
V
------
E
K
A
F
K
I
L
E
F
L
K
L
S
H
L
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
----
F
N
G
-
Q
I
I
A
E
-
G
--
R
G
E
E
E
I
K
--
N
---
V
L
-
S
D
P
K
V
-
V
------
E
I
Y
I
G
------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
59.85
33%
-96
- C1 -
4U00
3
?
A:
[5-218]
---------------------------------------------------------------------
I
R
I
R
N
L
H
K
W
F
--
G
-
P
-------
L
----
H
V
--
L
K
----
G
I
H
L
----
E
V
-
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
--
G
E
V
--
V
V
D
-------
G
LSVK
D
D
R
-------
A
L
R
E
-----
I
R
--
R
--
E
V
--
G
--
M
V
F
--
Q
Q
F
N
L
F
P
H
---
M
T
V
L
E
N
V
-
T
L
A
--------------
P
M
-----
R
V
R
R
W
P
----------
R
E
K
----
A
E
------
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
----
D
G
G
-
Q
I
V
E
E
-
G
--
R
P
E
E
I
F
T
--
R
---
P
K
-
E
E
R
T
R
-
S
------
F
L
Q
R
V
------
L
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
59.64
32%
-110
- C1 -
1G9X
3
LIVG_METJA
B:
[12-232]
-------------------------------------------------------------------------
N
I
V
K
Y
F
--
G
-
E
-------
F
----
K
A
--
L
D
----
G
V
S
I
----
S
V
-
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
--
G
R
V
--
Y
F
E
-------
N
----
K
D
I
-------
T
N
K
E
-----
P
A
--
E
L
Y
H
Y
--
G
--
I
V
R
T
F
Q
T
P
Q
P
L
K
E
---
M
T
V
L
E
N
L
-
L
I
G
------------
E
I
N
P
-----
G
E
S
P
L
N
SLFYKKWIPK
E
E
E
----
M
V
------
E
K
A
F
K
I
L
E
F
L
K
L
S
H
L
Y
D
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
K
-
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
----
F
N
G
-
Q
I
I
A
E
-
G
--
R
G
E
E
E
I
K
--
N
---
V
L
-
S
D
P
K
V
-
V
------
E
I
Y
I
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
59.33
33%
-97
- C1 -
4U02
1
?
A:
[5-218]
---------------------------------------------------------------------
I
R
I
R
N
L
H
K
W
F
--
G
-
P
-------
L
----
H
V
--
L
K
----
G
I
H
L
----
E
V
-
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
--
G
E
V
--
V
V
D
-------
G
LSVK
D
D
R
-------
A
L
R
E
-----
I
R
--
R
--
E
V
--
G
--
M
V
F
--
Q
Q
F
N
L
F
P
H
---
M
T
V
L
E
N
V
-
T
L
A
--------------
P
M
-----
R
V
R
R
W
P
----------
R
E
K
----
A
E
------
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
----
D
G
G
-
Q
I
V
E
E
-
G
--
R
P
E
E
I
F
T
--
R
---
P
K
-
E
E
R
T
R
-
S
------
F
L
Q
R
V
------
L
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
59.30
29%
-113
- C1 -
1OXU
7
?
A:
[2-243]
-------------------------------------------------------------------
V
R
I
I
V
K
N
V
S
K
V
F
--
K
-
K
-------
G
----
K
V
VA
L
D
----
N
V
N
I
----
N
I
-
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
--
G
E
L
--
Y
F
D
------------
D
R
L
-------
V
A
S
N
GKLIV
P
P
--
E
D
R
K
I
--
G
--
M
V
F
--
Q
T
W
A
L
Y
P
N
---
L
T
A
F
E
N
I
-------------------------
A
F
P
L
T
N
----------
M
K
M
S
K
E
E
I
R
------
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
----
V
K
G
-
K
L
V
-------------------------
Q
V
-
G
-------
K
P
E
D
------
L
Y
D
---------------------------
N
P
V
S
I
Q
V
A
S
L
I
----
G
----
E
----
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
I
H
S
G
E
E
V
L
V
Y
V
R
K
D
K
I
K
V
F
E
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
59.24
33%
-100
- C1 -
4U02
1
?
B:
[5-218]
---------------------------------------------------------------------
I
R
I
R
N
L
H
K
W
F
--
G
-
P
-------
L
----
H
V
--
L
K
----
G
I
H
L
----
E
V
-
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
--
G
E
V
--
V
V
D
-------
G
LSVK
D
D
R
-------
A
L
R
E
-----
I
R
--
R
--
E
V
--
G
--
M
V
F
--
Q
Q
F
N
L
F
P
H
---
M
T
V
L
E
N
V
-
T
L
A
--------------
P
M
-----
R
V
R
R
W
P
----------
R
E
K
----
A
E
------
K
K
A
L
E
L
L
E
R
V
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
----
D
G
G
-
Q
I
V
E
E
-
G
--
R
P
E
E
I
F
T
--
R
---
P
K
-
E
E
R
T
R
-
S
------
F
L
Q
R
V
------
L
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
58.19
23%
-68
- C1 -
1OXS
23
?
C:
[1-352]
------------------------------------------------------------------M
V
R
I
I
V
K
N
V
S
K
V
F
KK
G
-
K
-------
V
----
V
A
--
L
D
----
N
V
N
I
----
N
I
-
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
--
G
E
L
--
Y
F
D
-------
D
----
R
L
V
-------
A
S
N
G
-----
K
L
IV
P
P
E
D
R
--
K
--
I
G
M
V
F
Q
T
W
A
L
Y
P
N
---
L
T
A
F
E
N
I
-
A
F
P
-----------
L
T
N
M
K
-----
M
----
S
----------
K
E
E
----
I
R
------
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
----
V
K
G
-
K
L
V
Q
V
-
G
-------
K
P
--
E
---
D
L
-
Y
D
N
----------------------------------------------------
P
V
S
I
Q
V
A
S
L
I
----
G
----
E
--------------------------------
I
N
E
L
E
G
K
V
T
--
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
---------------------------------------------------------
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
D
S
E
E
E
I
F
T
Y
S
D
H
P
-
I
-
H
S
G
E
E
V
L
V
-
Y
V
R
K
D
K
I
K
V
F
E
K
------------------------------------------------------------------------
19
PsiBlast_PDB
58.12
30%
-96
- C1 -
2OLJ
4
?
A:
[25-239]
---------------------------------------------------------------------
I
D
V
H
Q
L
K
K
S
F
--
G
-
S
-------
L
----
E
V
--
L
K
----
G
I
N
V
----
H
I
-
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
--
G
E
I
--
I
I
D
-------
G
INL-
K
A
K
-------
D
T
N
L
-----
N
K
--
V
R
E
E
V
--
G
--
M
V
F
--
Q
R
F
N
L
F
P
H
---
M
T
V
L
N
N
I
-
T
L
A
--------------
P
M
-----
K
V
R
K
W
P
----------
R
E
K
----
A
E
------
A
K
A
M
E
L
L
D
K
V
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
----
D
G
G
-
Y
I
I
E
E
-
G
--
K
P
E
D
L
F
D
--
R
---
P
Q
-
H
E
R
T
K
-
A
------
F
L
S
K
V
------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
57.91
18%
-47
- C1 -
3J16
4
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
CPF
D
A
I
Q
I
I
N
L
P
T
N
L
--
E
-
A
-------
H
----
V
T
--
H
R
YSAN
S
F
K
L
H
R
L
P
T
P
-
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
--
G
R
F
--
D
D
P
-------
P
----
E
W
Q
-------
E
I
I
K
-----
Y
F
--
R
G
S
E
L
--
Q
--
N
Y
F
T
K
M
L
E
D
D
I
K
A
---
I
I
K
P
Q
Y
V
D
N
I
P
-----------
R
A
I
K
G
-----
P
V
Q
K
V
G
----------
E
L
L
----
K
L
R
MEKS
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
-
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
V
Y
-
G
V
V
T
L
-
P
--
A
S
V
R
E
G
I
--
N
---
I
F
-
L
D
G
H
I
-
P
------
A
E
N
L
R
------
F
R
T
E
A
L
Q
F
RIADATE
D
--
L
----
Q
---
N
D
S
A
S
R
A
F
S
Y
P
S
L
K
----
K
----
T
QGD
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
G
Q
D
I
P
K
L
N
V
S
M
K
P
Q
K
I
A
P
K
F
P
G
-----------------
T
V
R
Q
L
F
F
K
K
I
R
G
Q
F
L
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
I
I
D
Q
----------
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
R
I
I
C
S
K
V
I
R
R
F
I
-
L
-
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
G
I
PS
K
N
A
H
A
R
A
P
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
F
R
RDPNSF
R
P
R
I
N
K
L
DS
Q
M
D
K
E
Q
K
S
S
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