@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0122: (2015-11-28 )
MTKLRRFRFPLRFYFTLMFVLTMLFSVLASLLLVAAIVFTFFQGVLTTHVLQVSALAVVFLSLVIASISMWYGSYHLTKPILDISRIVSNVADGDFEGHIYRNSNRRKSYEYYNELDELSESINQMIVSLSHMDHMRKDFITNVSHELKTPIAAVANIVELLQDPELDEETQSELLGLVKTESLRLTRLCDTMLQMSRVDNQETIGELSSVRVDEQIRQAMISLTERWQAKRINFQLDSKPYTVYSNSDLLMQVWINLLDNAIKYSDDIVDLRVRMEETNNHYLRVIISDKGRGISQYDVQHIFDKFYQADQSHNQQGNGLGLAIVKRIIVLCKGRISVSSQFEIGTEFCVELPLS
Atome Classification :
(20 SA)
-------------------------.........10........20........30........40..-.....----.50........60.......-------.70........80........90........100.......110.......120.......130.......140--........150.......160...--..--..170.......180.......190.......200..--.....210--------...----...-----..220---.......230-.......---.-240-...--......250.......260....-..--------.270-.--........280........290.......300.......310--.--....--..320.......330........340.......350....-----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------MTK
L
R
R
F
R
F
P
L
R
F
Y
F
T
L
M
F
V
L
T
M
L
F
S
V
L
A
S
L
L
L
V
A
A
I
V
F
T
F
F
Q
-
G
V
L
T
T
----
H
V
L
Q
V
S
A
L
A
V
V
F
L
S
L
V
I
A
S
I
-------
S
M
W
Y
GSYHLT
K
P
I
L
D
I
S
R
I
V
S
N
VADGDFE
G
H
I
Y
RNSNRR
K
S
Y
E
Y
Y
N
E
L
D
E
L
S
E
S
I
N
Q
M
I
V
S
L
S
H
M
D
H
M
R
K
D
F
I
---
T
N
V
S
H
E
LK
T
P
I
A
A
V
A
N
I
V
E
L
LQDP--EL--
D
E
E
T
Q
S
E
L
L
G
L
VKTES
L
R
L
T
R
L
C
D
T
M
L
Q
M
SRVD
N
Q
E
T
--
I
G
E
L
S
S
V
---------
R
V
D
----
E
Q
I
-----
R
Q
A
M
I
---
S
L
T
E
R
WQA
K
--
R
I
N
F
Q
LD---S-K---
P
Y
T
--
V
YSNS
D
L
L
M
Q
V
W
I
N
L
L
D
N
A
IKYS-D
D
--------
I
V
---
D
--
L
R
V
R
M
EETNN-
H
Y
L
R
V
I
I
SDKGRGI
S
Q
Y
D
V
Q
H
I
F
D
K
F
Y
Q
ADQ--S--HNQQ--GNG
L
G
L
A
I
V
K
R
I
I
V
-
L
CKGRISVSSQFEIGT
E
F
C
VELPLS-----
8
PsiBlast_PDB
91.35
32%
-115
- C4 -
4JAU
1
?
A:
[13-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
D
R
M
K
T
E
F
I
---
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
LG
E
L
--
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
--
Q
I
N
R
E
K
V
---------
D
L
C
----
D
L
V
-----
E
S
A
V
N
---
A
I
K
E
F
A
S
S
H
--
N
V
N
V
L
F
E
---
S
-
N
VPC
P
V
E
--
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
--------
A
P
---
D
K
Y
V
K
V
I
L
D
E
K
D
G
-
G
V
L
-
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
-------------
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
------
22
PsiBlast_CBE
90.42
32%
-101
- C4 -
4JAV
6
?
B:
[13-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
D
R
M
K
T
E
F
I
---
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
LG
E
L
--
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
--
Q
I
N
R
E
K
V
---------
D
L
C
----
D
L
V
-----
E
S
A
V
N
---
A
I
K
E
F
A
S
S
H
--
N
V
N
V
L
F
E
---
S
-
N
VPC
P
V
E
--
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
--------
A
P
---
D
K
Y
V
K
V
I
L
D
E
K
D
G
-
G
V
L
-
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
LT
Y
E
V
P
--
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-----
6
PsiBlast_PDB
90.15
32%
-108
- C4 -
4JAV
6
?
A:
[13-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
D
R
M
K
T
E
F
I
---
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
LG
E
L
--
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
--
Q
I
N
R
E
K
V
---------
D
L
C
----
D
L
V
-----
E
S
A
V
N
---
A
I
K
E
F
A
S
S
H
--
N
V
N
V
L
F
E
---
S
-
N
VPC
P
V
E
--
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
--------
A
P
---
D
K
Y
V
K
V
I
L
D
E
K
D
G
-
G
V
L
-
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
LT
Y
E
V
P
--
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-----
7
PsiBlast_PDB
89.03
32%
-104
- C4 -
4JAS
2
?
A:
[13-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
D
R
M
K
T
E
F
I
---
A
N
I
S
H
E
L
R
T
P
L
T
V
I
K
G
Y
A
E
M
I
Y
N
S
L
G
E
L
--
D
L
S
T
L
K
E
F
L
E
T
I
I
E
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
--
Q
I
N
R
E
K
V
---------
D
L
C
----
D
L
V
-----
E
S
A
V
N
---
A
I
K
E
F
A
S
S
H
--
N
V
N
V
L
F
E
---
S
-
N
VPC
P
V
E
--
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
--------
A
P
---
D
K
Y
V
K
V
I
L
D
E
K
D
G
-
G
V
L
-
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
L
T
Y
E
V
P
--
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-----
23
PsiBlast_CBE
88.79
32%
-94
- C4 -
3DGE
2
?
B:
[14-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
---
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
LG
E
L
--
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
--
Q
I
N
R
E
K
V
---------
D
L
C
----
D
L
V
-----
E
S
A
V
N
---
A
I
K
E
F
A
S
S
H
--
N
V
N
V
L
F
E
---
S
-
N
VPC
P
V
E
--
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
--------
A
P
---
D
KY
V
K
V
I
L
D
E
K
D
G
-
G
V
L
-
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
LT
Y
E
V
P
--
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-----
5
PsiBlast_PDB
88.55
32%
-97
- C4 -
3DGE
3
?
A:
[14-246]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
D
R
M
K
T
E
F
I
---
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
L
G
E
L
--
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
--
Q
I
N
R
E
K
V
---------
D
L
C
----
D
L
V
-----
E
S
A
V
N
---
A
I
K
E
F
A
S
S
H
--
N
V
N
V
L
F
E
---
S
-
N
VPC
P
V
E
--
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
--------
A
P
---
D
K
Y
V
K
V
I
L
D
E
K
D
G
-
G
V
L
-
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
S
--
S
LT
Y
E
V
P
--
G
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-----
4
PsiBlast_PDB
88.29
32%
-110
- C4 -
2C2A
2
?
A:
[13-246]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
I
D
R
M
K
T
E
F
I
---
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
LG
E
L
--
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
--
Q
I
N
R
E
K
V
---------
D
L
C
----
D
L
V
-----
E
S
A
V
N
---
A
I
K
E
F
A
S
S
H
--
N
V
N
V
L
F
E
---
S
-
N
VPC
P
V
E
--
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
K
K
D
--------
A
P
---
D
K
Y
V
K
V
I
L
D
E
K
D
G
-
G
V
L
-
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
-------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-----
38
HHSearch
86.64
31%
-108
- C4 -
2C2A
2
?
A:
[15-248]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
R
M
K
T
E
F
I
---
A
N
I
S
H
E
L
R
T
P
L
T
A
I
K
A
Y
A
E
T
I
Y
N
S
--
L
G
EL
D
L
S
T
L
K
E
F
L
E
V
I
I
D
Q
S
N
H
L
E
N
L
L
N
E
L
L
D
F
S
R
L
E
R
K
S
L
--
Q
I
N
R
E
K
V
---------
D
L
C
----
D
L
V
-----
E
S
A
V
N
---
A
I
K
E
F
A
S
S
H
--
N
V
N
V
L
F
E
S
NV
P
-
C
---
P
V
E
--
A
Y
I
D
P
T
R
I
R
Q
V
L
L
N
L
L
N
N
G
V
K
Y
S
-
K
K
--------
D
A
P
D
K
Y
--
V
K
V
I
L
D
E
-
K
D
-
G
G
V
L
I
I
V
E
D
N
G
I
G
I
P
D
H
A
K
D
R
I
F
E
Q
F
Y
R
V
D
-------------
T
G
L
G
L
A
I
T
K
E
I
V
E
-
L
H
G
G
R
I
W
V
E
S
E
V
G
K
G
S
R
F
F
V
W
I
P
K
D
-----
2
PsiBlast_PDB
83.67
34%
-92
- C4 -
4U7O
1
?
A:
[31-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
N
D
R
K
Q
F
V
---
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
--
A
W
K-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
--
R
V
D
M
E
L
V
---------
N
I
N
----
E
M
F
N
Y
V
L
D
R
F
D
M
I
---
L
K
K
D
D
N
P
A
K
Y
Y
T
I
K
R
E
F
T
---
K
-
R
---
D
L
W
--
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
-
P
D
--------
G
G
---
V
--
V
T
C
R
L
L
E
T
H
N
-
Q
V
I
-
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
-------
Q
G
--
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-----
21
PsiBlast_CBE
80.63
34%
-94
- C4 -
4U7O
1
?
B:
[37-261]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
V
---
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
--
A
W
K-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
------
T
--
R
V
D
M
E
L
V
---------
N
I
N
----
E
M
F
N
Y
V
L
D
R
F
D
M
I
---
L
K
K
D
D
N
P
A
K
Y
Y
T
I
K
R
E
F
T
---
K
-
R
---
D
L
W
--
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
-
P
D
--------
G
G
---
V
--
V
T
C
R
L
L
E
T
H
N
-
Q
V
I
-
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
V
D
K
AR-----
Q
G
--
G
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-----
1
PsiBlast_PDB
79.37
34%
-93
- C4 -
4U7N
-
?
A:
[39-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
S
N
V
S
H
E
L
R
T
P
L
T
S
L
R
S
Y
I
E
A
L
S
D
G
--
A
W
K-
D
P
E
V
A
P
G
F
L
K
V
T
Q
E
E
T
D
R
M
I
R
M
I
N
E
L
L
S
L
S
R
M
D
S
G
T
T
--
R
V
D
M
E
L
V
---------
N
I
N
----
E
M
F
N
Y
V
L
D
R
F
D
M
I
---
L
K
K
D
D
N
---Y
Y
T
I
K
R
E
F
T
---
K
-
R
---
D
L
W
--
V
E
I
D
T
D
K
F
T
Q
V
L
D
N
I
M
N
N
A
I
K
Y
S
-
P
D
--------
G
G
---
V
--
V
T
C
R
L
L
E
T
H
N
-
Q
V
I
-
I
S
I
S
D
Q
G
L
G
I
P
R
A
D
L
G
H
V
F
D
R
F
F
R
---------------
T
G
L
G
L
A
I
S
K
E
V
V
Q
-
M
L
G
G
R
I
W
V
D
S
V
E
G
K
G
S
T
F
Y
I
S
L
P
Y
E
-----
9
PsiBlast_PDB
74.05
25%
-81
- C4 -
4Q20
-
DIVL_CAUCR
A:
[25-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
A
D
R
S
A
A
L
A
E
A
E
R
L
K
R
D
F
V
---
G
N
V
S
Y
E
L
R
T
P
L
T
T
I
I
G
Y
S
E
L
L
E
R
A
--
D
----
S
E
R
G
R
N
H
V
A
A
V
R
A
A
A
T
Q
L
A
R
S
I
D
D
V
L
D
M
A
Q
I
D
A
G
E
M
--
A
L
E
I
E
D
I
---------
R
V
S
----
D
L
L
-----
L
N
A
Q
E
---
R
A
L
K
D
A
Q
L
G
--
G
V
T
L
A
V
E
---
C
-
E
---
E
D
V
GL
I
R
G
D
G
K
R
L
A
Q
T
L
D
H
L
V
E
N
A
L
R
Q
T
-
P
P
-------------
G
--
G
R
V
T
L
S
A
R
R
A
L
G
E
V
R
L
D
V
S
D
T
G
R
G
V
P
F
H
V
Q
A
H
I
F
D
R
F
V
G
R
D
R
--
G
--------
G
P
G
L
G
L
A
L
V
K
A
L
V
E
-
L
H
G
G
W
V
A
L
E
S
E
P
G
N
G
S
T
F
T
C
H
L
P
E
T
-----
31
Fugue
69.94
15%
-91
- C4 -
1GKZ
8
BCKD_RAT
A:
[38-378]
-------------------------------
V
R
L
T
P
T
M
M
L
Y
S
G
R
S
Q
D
G
S
H
L
L
K
S
G
R
Y
L
Q
Q
E
L
P
V
R
I
A
H
-
R
I
K
G
F
----
R
S
L
P
F
I
I
G
C
N
P
T
I
L
H
V
H
E
L
Y
-------
I
R
A
F
Q
K
L
T
D
F
P
P
I
----------------------
K
D
Q
A
D
E
A
Q
Y
C
Q
L
V
R
Q
L
L
D
D
H
K
D
V
V
T
L
L
A
E
G
L
R
E
S
R
K
H
I
EDE
K
L
V
R
Y
F
L
D
K
T
L
T
S
R
L
G
I
R
M
L
A
T
H
H
--
L
A
--
L
H
E
D
K
P
D
F
V
G
I
I
C
T
R
L
S
-
P
K
K
I
I
E
K
W
V
D
F
A
R
R
L
C
E
H
K
--
Y
G
N
A
P
R
V
---------
R
I
N
----
G
H
-------------------------------------
V
---
A
A
R
--
F
P
F
I
P
M
P
L
D
Y
I
L
P
E
L
L
K
N
A
M
R
A
T
-
M
E
S
H
LDTPY
N
V
P
---
D
--
V
V
I
T
I
A
N
-
N
D
-
V
D
L
I
I
R
I
S
D
R
G
G
G
I
A
H
K
D
L
D
R
V
M
D
Y
H
F
T
-----
T
--
A
P
M
H
--
G
F
G
F
G
L
P
T
S
R
A
Y
A
E
-
Y
L
G
G
S
L
Q
L
Q
S
L
Q
G
I
G
T
D
V
Y
L
R
L
R
H
I
DGREE
14
PsiBlast_PDB
69.86
23%
-66
- C4 -
4BIV
2
CPXA_ECOLI
A:
[29-294]
-------------------------------------------------------------------------------------------------------------------
K
P
A
R
K
L
K
N
A
A
D
E
V
A
Q
G
N
L
R
Q
H
P
E
L
E
A
G
P
Q
-------
E
F
L
A
A
G
A
S
F
N
Q
M
V
T
A
L
E
R
M
M
T
S
Q
Q
R
L
L
---
S
D
I
S
H
E
L
R
T
P
L
T
R
L
Q
L
G
T
A
L
L
R
R
--------
R
S
G
E
S
K
E
L
E
R
I
E
T
E
A
Q
R
L
D
S
M
I
N
D
L
L
V
M
S
R
--
N
Q
Q
K
--
N
A
L
V
S
E
T
---------
I
K
A
----
N
Q
L
-----
W
S
E
V
L
D
N
A
A
F
E
A
E
Q
M
G
K
--
S
L
T
V
N
F
P
---
P
-
G
---
P
W
P
--
L
Y
G
N
P
N
A
L
E
S
A
L
E
N
I
V
R
N
A
L
R
Y
S
-
H
T
--------
K
I
---
E
--
V
G
F
A
V
D
K
D
G
----
I
T
I
T
V
D
D
D
G
P
G
V
S
P
E
D
R
E
Q
I
F
R
P
F
Y
R
T
D
E
--
A
--
R
D
R
E
SG
G
T
G
L
G
L
A
I
V
E
T
A
I
Q
-
Q
H
R
G
W
V
K
A
E
D
S
P
L
G
G
L
R
L
V
I
W
L
P
L
Y
-----
3
PsiBlast_PDB
69.03
33%
-86
- C4 -
4I5S
-
?
A:
[211-432]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
V
---
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
--
A
L
--
T
E
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
-----
S
H
L
D
V
E
L
T
N
F
T
A
F
M
N
Y
I
L
D
R
F
D
Q
I
Q
S
Q
Q
S
-----
T
-------
E
I
I
R
D
Y
P
D
K
--
S
V
W
I
E
I
D
------------------
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
-
P
D
--------
G
G
---
K
--
V
T
I
T
M
Q
T
T
D
T
-
Q
-
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
AR-----------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
-------
28
Fugue
68.87
25%
-81
- C4 -
4I5S
-
?
A:
[37-432]
N
N
N
Q
V
K
Q
L
N
A
K
V
R
S
L
I
T
G
H
Y
T
D
K
LK
V
E
D
N
S
D
L
S
E
L
V
N
N
V
N
D
L
S
E
V
F
R
L
T
H
E
N
L
A
Q
E
K
N
R
L
T
S
I
L
S
Y
M
T
D
G
V
L
A
T
D
RSG
K
I
T
V
I
N
D
M
A
Q
K
Q
L
N
V
T
R
E
Q
A
LECNILD
I
L
D
D
D
S
Y
T
Y
N
D
L
I
T
K
T
P
E
I
V
L
T
R
R
D
E
Y
D
E
F
I
T
L
R
I
R
F
A
L
N
R
R
E
--
S
G
F
I
S
G
L
I
A
V
L
H
D
A
T
E
Q
E
K
E
E
R
E
R
R
L
F
V
---
S
N
V
S
H
E
L
R
T
P
L
T
S
V
K
S
Y
L
E
A
L
D
D
G
--
A
L
--
T
E
S
V
A
P
S
F
I
K
V
S
L
D
E
T
N
R
M
M
R
M
I
T
D
L
L
S
L
S
R
S
H
L
-------
D
V
E
L
T
---------
N
F
T
----
A
F
M
-----
N
Y
I
L
D
---
R
F
D
Q
I
Q
S
Q
Q
--
S
T
E
I
I
R
D
YP-
D
-
K
---
S
V
W
--
I
E
I
D
T
D
K
M
T
Q
V
I
D
N
I
L
N
N
A
I
K
Y
S
-
P
D
--------
G
G
---
K
--
V
T
I
T
M
Q
T
T
D
T
-
Q
-
L
I
L
S
I
S
D
Q
G
L
G
I
P
K
K
D
L
P
L
I
F
D
R
F
Y
R
V
D
K
--
A
--
R
-------
G
L
G
L
A
I
A
K
E
I
V
K
-
Q
H
K
G
F
I
W
A
N
S
E
E
G
E
G
S
T
F
T
I
V
L
P
-------
40
HHSearch
68.32
25%
-102
- C4 -
3A0R
1
?
A:
[131-345]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
G
E
M
T
---
A
R
V
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
M
K
K
H
--
L
D
--
D
P
E
T
L
K
K
Y
I
N
I
I
T
N
E
L
S
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
------
V
L
E
F
T
E
F
---------
N
L
N
----
E
L
I
-----
R
E
V
Y
V
---
L
F
E
E
K
I
R
K
M
--
N
I
D
F
C
F
E
T
D-
N
-
E
---
D
L
R
--
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
-
G
E
--------
N
G
---
K
--
I
K
I
T
S
E
D
-
M
Y
-
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
----------------
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
K
T
-----
43
HHSearch
66.23
27%
-111
* C4 *
3A0Y
-
?
A:
[607-751]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
F
---------
N
L
N
----
E
L
I
-----
R
E
V
Y
V
---
L
F
E
E
K
I
R
K
M
--
N
I
D
F
C
F
E
T
D-
N
-
E
---
D
L
R
--
V
E
A
D
R
T
R
I
K
Q
V
L
I
N
L
V
Q
N
A
I
E
A
T
-
G
E
--------
N
G
---
K
--
I
K
I
T
S
E
D
-
M
Y
-
T
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
K
E
K
I
F
S
P
F
F
T
T
K
------------
G
T
G
L
G
L
S
I
C
R
K
I
I
E
D
E
H
G
G
K
I
W
T
E
N
R
-
E
N
G
V
V
F
I
F
E
I
P
K
T
-----
47
HHSearch
65.95
25%
-112
- C4 -
1ID0
2
A:
[3-144]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
---------
P
V
A
----
P
L
L
-----
D
N
L
T
S
---
A
L
N
K
V
Y
Q
R
K
--
G
V
N
I
S
L
D
---
I
S
P
---
E
I
S
--
F
V
G
E
Q
N
D
F
V
E
V
M
G
N
V
L
D
N
A
C
K
Y
C
-
L
E
--------
F
V
-------
E
I
S
A
R
Q
-
T
D
-
E
H
L
Y
I
V
V
E
D
D
G
P
G
I
P
L
S
K
R
E
V
I
F
D
R
G
Q
R
V
D
T
------
L
R
P
--
G
Q
G
V
G
L
A
V
A
R
E
I
T
E
-
Q
Y
E
G
K
I
V
A
G
E
S
M
L
G
G
A
R
M
E
V
I
F
G
R
Q
-----
20
PsiBlast_PDB
65.94
21%
-94
- C4 -
3D36
4
?
A:
[3-225]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
V
I
R
----------
L
A
---
A
S
I
S
H
E
I
R
N
P
L
T
A
A
R
G
F
I
Q
L
I
E
E
Q
--
P
L
--
A
A
D
K
R
R
Q
Y
A
R
I
A
I
E
E
L
D
R
A
E
A
I
I
T
D
Y
L
T
F
A
K
-
P
A
P
E
T
--
P
E
K
L
N
------------
V
K
----
L
E
I
-----
E
R
V
I
D
---
I
L
R
P
L
A
N
M
S
--
C
V
D
I
Q
A
T
---
L
-
A
---
P
F
S
--
V
I
G
E
R
E
K
F
R
Q
C
L
L
N
V
M
K
N
A
I
E
A
M
-
P
N
--------
G
G
---
T
--
L
Q
V
Y
V
S
I
D
N
G
-
R
V
L
-
I
R
I
A
D
T
G
V
G
M
T
K
E
Q
L
E
R
L
G
E
P
Y
F
T
-----
T
--
K
G
V
K
--
G
T
G
L
G
M
M
V
V
Y
R
I
I
E
-
S
M
N
G
T
I
R
I
E
S
E
I
H
K
G
T
T
V
S
I
Y
L
P
L
A
-----