@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0125: (2015-11-28 )
MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKLCKQLIETLVESMGITVPVAIHLDHGHYDDALECIEVGYTSIMFDGSHLPVEENLEKAREVVAKAHAKGISVEAEVGTIGGEEDGIVGKGELAPIEDAKAMVETGIDFLAAGIGNIHGPYPANWEGLDLDHLKKLTEAVPGFPIVLHGGSGIPDDQIQEAIKLGVAKVNVNTECQLAFCQATRDYAVEFNANEAEYMKKKLFDPRKFLKPGFDAITEAVEERIDVFGSANKA
Atome Classification :
(24 SA)
--.....---....10........20........30........40........50........---60.---.-------......70...-...-..80......-.-.90--------------....----...---.100.......110.......120.......130.......140......---.150--.-.----....---.160-..-.-----....170.......180.--.-..-.--..190--.......----------200.--......210--------------------...---------------------.---------------------.---------------------.---------------------..220.......230.......240.......250...-----....260.......270.......280.......290.-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MAIV
S
---
A
E
K
F
V
Q
A
ARDN
G
Y
A
VGGFNTN
N
L
E
W
T
Q
A
I
L
R
A
AEAKKA
P
V
L
I
Q
TSMG
A
A
K
YM
G
G
---
Y
K
L
---
C
-------
K
Q
L
I
E
T
L
V
E
SM-G
I
T
-
V
P
V
A
I
H
L
DHG-H-Y
D
D
--------------
A
L
E
C
----
I
E
V---GY
T
S
I
M
FDGSHL
P
V
E
E
N
L
E
K
A
R
E
V
V
A
K
AHAKG
I
S
V
E
A
E
VGTIGGEEDGIV---GKGE--L-A----
P
I
E
D
---
A
K
A
M
-
V
E
-
T
-----
G
I
D
F
L
A
A
G
IGNIHGPYPA--N-WE-G--L
D
L
D
H
--
L
K
K
L
T
E
A----------VPG
F
--
P
I
V
L
HGGS---------------------GI
P
---------------------
D
---------------------
D
---------------------
Q
---------------------
I
Q
E
A
I
K
LG
V
A
K
V
NVNT
E
C
Q
L
A
F
C
QATR
D
Y
A
V
E
FNA
N
E
A
-----
E
Y
M
K
K
KLF
D
P
R
K
F
LKP
G
F
D
A
I
T
E
A
V
E
E
R
I
D
V
FGSANKA-
21
PsiBlast_CBE
96.73
45%
-93
- C1 -
4TO8
2
?
B:
[2-285]
---
P
L
V
S
---
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
A
A
R
Y
M
S
G
---
F
Y
T
---
I
-------
V
K
M
V
E
G
L
M
H
D
L
-
N
I
T
-
I
P
V
A
I
H
L
D
H
G
S
S
-
F
E
K
--------------
C
K
E
A
----
I
D
A
---
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
V
---
A
D
G
I
--
I
Y
A
----
D
P
K
E
---
C
Q
E
L
-
V
E
K
T
-----
G
I
D
A
L
A
P
A
L
G
S
V
H
---------
P
K
----
L
G
F
K
E
--
M
E
E
I
G
L
S
----------
T
-
G
L
--
P
L
V
L
H
G
G
T
---------------------
G
I
P
---------------------
T
---------------------
K
---------------------
D
---------------------
I
Q
K
A
I
P
F
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
---
L
N
N
D
-----------
K
E
V
Y
D
P
R
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
G
T
S
N
R
A
-
1
PsiBlast_PDB
96.73
45%
-94
- C1 -
4TO8
2
?
A:
[2-285]
---
P
L
V
S
---
M
K
E
M
L
I
D
A
K
E
N
G
Y
A
V
G
Q
Y
N
I
N
N
L
E
F
T
Q
A
I
L
E
A
S
Q
E
E
N
A
P
V
I
L
G
V
S
E
G
A
A
R
Y
M
S
G
---
F
Y
T
---
I
-------
V
K
M
V
E
G
L
M
H
D
L
-
N
I
T
-
I
P
V
A
I
H
L
D
H
G
S
S
-
F
E
K
--------------
C
K
E
A
----
I
D
A
---
G
F
T
S
V
M
I
D
A
S
H
S
P
F
E
E
N
V
A
T
T
K
K
V
V
E
Y
A
H
E
K
G
V
S
V
E
A
E
L
G
T
V
G
G
--
D
D
V
V
---
A
D
G
I
--
I
Y
A
----
D
P
K
E
---
C
Q
E
L
-
V
E
K
T
-----
G
I
D
A
L
A
P
A
L
G
S
V
H
G
--------
P
K
----
L
G
F
K
E
--
M
E
E
I
G
L
S
----------
T
-
G
L
--
P
L
V
L
H
G
G
T
---------------------
G
I
P
---------------------
T
---------------------
K
---------------------
D
---------------------
I
Q
K
A
I
P
F
G
T
A
K
I
N
V
N
T
E
N
Q
I
A
S
A
K
A
V
R
D
V
---
L
N
N
D
-----------
K
E
V
Y
D
P
R
K
Y
L
G
P
A
R
E
A
I
K
E
T
V
K
G
K
I
K
E
F
G
T
S
N
R
A
-
5
PsiBlast_PDB
89.44
38%
-99
- C1 -
3GAK
4
?
A:
[2-307]
---
P
L
C
T
---
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
D
M
---
I
Y
L
-----------
K
K
L
C
E
A
A
L
E
K
H
-
P
-
D
-
I
P
I
C
I
H
L
D
H
G
-----
D
--------------
T
L
E
S
V
K
M
A
I
D
L
---
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
G
V
S
V
E
A
E
L
G
---------------------
T
----
E
P
Q
D
---
A
K
K
F
-
V
E
L
T
-----
G
V
D
A
L
A
V
A
I
-------------------
L
A
I
D
R
--
V
K
T
I
S
D
-----------
L
T
G
I
--
P
L
V
M
H
G
S
S
---------------------
S
V
P
---------------------
K
---------------------
D
V
K
D
M
I
N
K
Y
G
G
K
MPDA
V
G
V
P
I
E
S
---------------------
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
--------------
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
2
PsiBlast_PDB
89.05
45%
-81
- C1 -
3Q94
10
?
A:
[6-288]
----
L
V
S
---
M
K
E
M
L
N
K
A
L
E
G
K
Y
A
V
G
Q
F
N
M
N
N
L
E
W
T
Q
A
I
L
A
A
A
E
E
E
K
S
P
V
I
L
G
V
S
E
G
A
A
R
H
M
T
G
---
F
K
T
---
V
-------
V
A
M
V
K
A
L
I
E
E
M
-
N
I
T
-
V
P
V
A
I
H
L
D
H
G
S
S
-
F
E
K
--------------
C
K
E
A
----
I
D
A
---
G
F
T
S
V
M
I
D
A
S
H
H
P
F
E
E
N
V
E
T
T
K
K
V
V
E
Y
A
H
A
R
N
V
S
V
E
A
E
L
G
T
V
G
G
Q
E
D
D
V
I
---
A
E
G
V
--
I
Y
A
----
D
P
A
E
---
C
K
H
L
-
V
E
A
T
-----
G
I
D
C
L
A
P
A
L
G
S
V
H
G
P
Y
K
G
EP
N
-
L
G
-
F
--
A
E
M
E
Q
--
V
R
D
F
T
--------------
G
V
--
P
L
V
L
H
G
G
T
---------------------
G
I
P
---------------------
T
---------------------
A
---------------------
D
---------------------
I
E
K
A
I
S
L
G
T
S
K
I
N
V
N
T
E
N
Q
I
E
F
T
K
A
V
R
---------
E
V
-----
L
N
K
D
Q
E
V
Y
D
P
R
K
F
I
G
P
G
R
D
A
I
K
A
T
V
I
G
K
I
R
E
F
G
S
N
G
K
A
-
40
HHSearch
87.08
41%
-82
- C1 -
2ISW
2
?
A:
[2-307]
---
P
L
C
T
---
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
D
----
M
I
Y
---
L
-------
K
K
L
C
E
A
A
--
L
E
K
H
P
D
-
I
P
I
C
I
H
L
D
H
G
D
T
-
L
E
S
--------------
V
K
M
A
----
I
D
L
---
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-------------
V
Q
--
L
-
T
----
E
P
Q
D
---
A
K
K
F
V
E
L
-
T
-----
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
--
K
S---
R
--
L
A
I
D
R
--
V
K
T
I
S
D
L
-----------
T
G
I
--
P
L
V
M
H
G
S
S
SVP
K
D
V
K
D
M
I
N
K
Y
GGKMPDAV
G
V
P
---------------------
I
---------------------
E
---------------------
S
---------------------
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
--------------
H
P
E
K
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
29
PsiBlast_CBE
86.89
38%
-90
- C1 -
2ISV
2
?
B:
[2-307]
---
P
L
C
T
---
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
D
M
---
I
Y
L
-----------
K
K
L
C
E
A
A
L
E
K
H
-
P
-
D
-
I
P
I
C
I
H
L
D
H
G
-----
D
--------------
T
L
E
S
V
K
M
A
I
D
L
---
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
---------
Q
---
N
T
V
Q
--
L
-
T
----
E
P
Q
D
---
A
K
K
F
-
V
E
L
T
-----
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
--------IR
L
A
I
D
R
--
V
K
T
I
S
D
-----------
L
T
G
I
--
P
L
V
M
H
G
S
S
---------------------
S
V
P
---------------------
K
---------------------
D
V
K
D
M
I
N
K
Y
GGKMPDAVGVP
I
E
S
---------------------
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
--------------
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
6
PsiBlast_PDB
86.51
38%
-94
- C1 -
2ISV
2
?
A:
[2-307]
---
P
L
C
T
---
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
D
M
---
I
Y
L
-----------
K
K
L
C
E
A
A
L
E
K
H
-
P
-
D
-
I
P
I
C
I
H
L
D
H
G
-----
D
--------------
T
L
E
S
V
K
M
A
I
D
L
---
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
-------------------
L
-
T
----
E
P
Q
D
---
A
K
K
F
-
V
E
L
T
-----
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
-----------R-
L
A
I
D
R
--
V
K
T
I
S
D
-----------
L
T
G
I
--
P
L
V
M
H
G
S
S
---------------------
S
V
P
---------------------
K
---------------------
D
V
K
D
M
I
N
K
Y
GGKMPDAVGVP
I
E
S
---------------------
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
--------------
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
7
PsiBlast_PDB
85.77
38%
-91
- C1 -
2ISW
2
?
A:
[2-307]
---
P
L
C
T
---
L
R
Q
M
L
G
E
A
R
K
H
K
Y
G
V
G
A
F
N
V
N
N
M
E
Q
I
Q
G
I
M
K
A
V
V
Q
L
K
S
P
V
I
L
Q
C
S
R
G
A
L
K
Y
S
D
M
---
I
Y
L
-----------
K
K
L
C
E
A
A
L
E
K
H
-
P
-
D
-
I
P
I
C
I
H
L
D
H
G
-----
D
--------------
T
L
E
S
V
K
M
A
I
D
L
---
G
F
S
S
V
M
I
D
A
S
H
H
P
F
D
E
N
V
R
I
T
K
E
V
V
A
Y
A
H
A
R
S
V
S
V
E
A
E
L
G
T
L
-------------
V
Q
--
L
-
T
----
E
P
Q
D
---
A
K
K
F
-
V
E
L
T
-----
G
V
D
A
L
A
V
A
I
G
T
S
H
G
A
Y
K
F
--
K
-
S
---R-
L
A
I
D
R
--
V
K
T
I
S
D
-----------
L
T
G
I
--
P
L
V
M
H
G
S
S
---------------------
S
V
P
---------------------
K
---------------------
D
V
K
D
M
I
N
K
Y
GGKMPDAVGVP
I
E
S
---------------------
I
V
H
A
I
G
E
G
V
C
K
I
N
V
D
S
D
S
R
M
A
M
T
G
A
I
R
K
V
F
V
E
H
P
E
K
--------------
F
D
P
R
D
Y
L
G
P
G
R
D
A
I
T
E
M
L
I
P
K
I
K
A
F
G
S
A
G
H
A
-
42
HHSearch
85.56
38%
-86
- C1 -
1GVF
11
KBAY_ECOLI
A:
[2-284]
---
S
I
I
S
---
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
A
----
L
E
E
---
I
-------
Y
A
L
C
S
A
Y
--
S
T
-
T
Y
N
-
M
P
L
A
L
H
L
D
H
H
E
S
-
L
D
D
--------------
I
R
R
K
----
V
H
A
---
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
-----------
S
A
F
--
L
-
T
----
D
P
Q
E
---
A
K
R
F
V
E
L
-
T
-----
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
S
---
K
-
T
P
-
K
--
I
D
F
Q
R
--
L
A
E
I
R
E
V
-----------
V
D
V
--
P
L
V
L
H
G
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
---------------------
F
---------------------
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
--------------
N
P
Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
-
30
PsiBlast_CBE
85.22
38%
-86
- C1 -
1GVF
12
KBAY_ECOLI
B:
[2-283]
---
S
I
I
S
---
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
A
L
E
E
I
Y
A
L
---
C
-------
S
A
Y
------
S
T
-
T
Y
N
-
M
P
L
A
L
H
L
D
H
H
-
E
S
L
D
D
--------------
I
R
R
K
----
V
H
A
---
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
G
V
E
-------------
S
-
A
----
F
L
T
D
P
Q
E
A
K
R
F
-
V
E
L
T
-----
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
-
S
--
K
-
T
P
-
K
--
I
D
F
Q
R
--
L
A
E
I
R
E
V
----------
V
-
D
V
--
P
L
V
L
H
G
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
---------------------
F
---------------------
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
--------------
N
P
Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
-
34
PsiBlast_CBE
85.17
35%
-85
- C1 -
3N9R
4
?
P:
[2-306]
----
L
V
K
---
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
----
I
D
M
---
A
-------
V
G
M
V
K
I
M
C
E
R
Y
-
P
-
H
-
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
--------------
C
E
K
A
----
V
K
A
---
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------------
A
VLVN
P
K
E
A
---
E
Q
F
V
-
K
E
-
S
-----
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
-
G
E
P
K
--
L
D
F
E
R
--
L
Q
E
V
K
R
-----------
L
T
N
I
--
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
---------------------
V
RKSYLDAGGDLKGSKGVPFEF
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
--------------
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
8
PsiBlast_PDB
85.16
37%
-79
- C1 -
2FJK
1
ALF_THECA
A:
[2-305]
----
L
V
T
---
G
L
E
I
L
R
K
A
R
A
E
G
Y
G
V
G
A
F
N
T
N
N
M
E
F
T
Q
A
I
L
E
A
A
E
E
M
K
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
-
G
G
---
R
A
L
---
T
-------
R
M
V
V
A
L
A
Q
E
A
R
-----
V
P
V
A
V
H
L
D
H
G
S
S
-
Y
E
S
--------------
V
L
K
A
----
L
R
E
---
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
K
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
V
D
E
K
D
A
L
--
L
-
T
----
N
P
E
E
---
A
R
I
F
-
M
E
R
T
-----
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
--
K
-
G
R
-
P
F-
I
D
H
P
R
--
L
A
R
I
A
K
L
----------
V
P
A
---
P
L
V
L
H
G
A
S
---------------------
A
V
P
---------------------
Q
E
L
V
E
R
F
R
A
A
G
G
E
I
G
EASGIH
P
E
---------------------
D
---------------------
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
V
R
E
T
---
L
G
K
N
P
K
-----
E
------
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
23
PsiBlast_CBE
85.09
37%
-81
- C1 -
1RVG
6
?
C:
[2-305]
----
L
V
T
---
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
-
G
G
---
R
A
L
---
T
-------
L
M
A
V
E
L
A
K
E
A
----
R
-
V
P
V
A
V
H
L
D
H
G
S
S
-
Y
E
S
--------------
V
L
R
A
----
L
R
A
---
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
VDE
K
D
A
L
--
L
-
T
----
N
P
E
E
---
A
R
I
F
-
M
E
R
T
-----
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
--
K
-
G
R
-
P
--
F
-
I
D
H
AR
L
E
R
I
A
R
L
----------
V
P
A
---
P
L
V
L
H
G
A
S
---------------------
A
V
P
PELVERFRASGGEIGEAAGIH
P
---------------------
E
---------------------
D
---------------------
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
---
A
L
N
K
N
P
K
-----
E
------
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
12
PsiBlast_PDB
85.07
35%
-86
- C1 -
3C56
3
ALF_HELPY
A:
[2-306]
----
L
V
K
---
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
----
I
D
M
---
A
-------
V
G
M
V
K
I
M
C
E
R
Y
-
P
-
H
-
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
--------------
C
E
K
A
----
V
K
A
---
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------------
A
VLVN
P
K
E
A
---
E
Q
F
V
-
K
E
-
S
-----
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
-
G
E
P
K
--
L
D
F
E
R
--
L
Q
E
V
K
R
-----------
L
T
N
I
--
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
---------------------
V
R
K
S
Y
L
D
A
GGDLKGSKGVP
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
--------------
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
10
PsiBlast_PDB
85.00
35%
-91
- C1 -
3C4U
2
ALF_HELPY
A:
[2-306]
----
L
V
K
---
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
----
I
D
M
---
A
-------
V
G
M
V
K
I
M
C
E
R
Y
-
P
-
H
-
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
--------------
C
E
K
A
----
V
K
A
---
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
---------------------VLVN
P
K
E
A
---
E
Q
F
V
-
K
E
-
S
-----
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
-
G
E
P
K
--
L
D
F
E
R
--
L
Q
E
V
K
R
-----------
L
T
N
I
--
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
---------------------
V
R
K
S
Y
L
D
A
GGDLKGSKGVP
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
--------------
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
24
PsiBlast_CBE
84.53
37%
-81
- C1 -
1RVG
6
?
B:
[2-305]
----
L
V
T
---
G
L
E
I
L
K
K
A
R
E
E
G
Y
G
V
G
A
F
N
V
N
N
M
E
F
L
Q
A
V
L
E
A
A
E
E
Q
R
S
P
V
I
L
A
L
S
E
G
A
M
K
Y
-
G
G
---
R
A
L
---
T
-------
L
M
A
V
E
L
A
K
E
A
----
R
-
V
P
V
A
V
H
L
D
H
G
S
S
-
Y
E
S
--------------
V
L
R
A
----
L
R
A
---
G
F
T
S
V
M
I
D
K
S
H
E
D
F
E
T
N
V
R
E
T
R
R
V
V
E
A
A
H
A
V
G
V
T
V
E
A
E
L
G
R
L
A
G
I
E
E
H
V
A
VDE
K
D
A
L
--
L
-
T
----
N
P
E
E
---
A
R
I
F
-
M
E
R
T
-----
G
A
D
Y
L
A
V
A
I
G
T
S
H
G
A
Y
K
G
--
K
-
G
R
-
P
--
F
-
I
D
H
A
R
L
E
R
I
A
R
L
----------
V
P
A
---
P
L
V
L
H
G
A
S
---------------------
A
V
P
P
E
L
V
E
R
F
R
A
S
G
G
E
I
G
E
A
A
G
I
H
P
---------------------
E
---------------------
D
---------------------
I
K
K
A
I
S
L
G
I
A
K
I
N
T
D
T
D
L
R
L
A
F
T
A
L
I
R
E
---
A
L
N
K
N
P
K
-----
E
------
F
D
P
R
K
Y
L
G
P
A
R
E
A
V
K
E
V
V
K
S
R
M
E
L
F
G
S
V
G
R
A
-
9
PsiBlast_PDB
84.47
38%
-91
- C1 -
1GVF
11
KBAY_ECOLI
A:
[2-283]
---
S
I
I
S
---
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
H
I
A
L
E
E
I
Y
A
L
---
C
-------
S
A
Y
------
S
T
-
T
Y
N
-
M
P
L
A
L
H
L
D
H
H
-
E
S
L
D
D
--------------
I
R
R
K
----
V
H
A
---
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
----------------
S
-
A
----
F
L
T
D
P
Q
E
A
K
R
F
-
V
E
L
T
-----
G
V
D
S
L
A
V
A
I
G
T
A
H
G
L
Y
-
S
--
K
-
T
P
-
K
--
I
D
F
Q
R
--
L
A
E
I
R
E
V
----------
V
-
D
V
--
P
L
V
L
H
G
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
---------------------
F
---------------------
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
--------------
N
P
Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
-
38
PsiBlast_CBE
84.34
35%
-88
- C1 -
3C4U
2
ALF_HELPY
B:
[2-306]
----
L
V
K
---
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
----
I
D
M
---
A
-------
V
G
M
V
K
I
M
C
E
R
Y
-
P
-
H
-
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
--------------
C
E
K
A
----
V
K
A
---
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
---------------------VLVN
P
K
E
A
---
E
Q
F
V
-
K
E
-
S
-----
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
-
G
E
P
K
--
L
D
F
E
R
--
L
Q
E
V
K
R
-----------
L
T
N
I
--
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
---------------------
V
RKSYLDAGGDLKGSKGVPFEF
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
--------------
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
64
Fugue
84.25
37%
-91
* C1 *
1GVF
11
KBAY_ECOLI
A:
[2-285]
SI
I
S
------
T
K
Y
L
L
Q
D
A
Q
A
N
G
Y
A
V
P
A
F
N
I
H
N
A
E
T
I
Q
A
I
L
E
V
C
S
E
M
R
S
P
V
I
L
A
G
T
P
G
T
F
K
----------
H
IA
L
-------
E
E
I
Y
A
L
C
S
A
Y
S
-
T
T
Y
N
M
P
L
A
L
H
L
D
H
H
-
E
---
S
--------------
L
D
D
I
----
R
R
K
V
H
A
G
V
R
S
A
M
I
D
G
S
H
F
P
F
A
E
N
V
K
L
V
K
S
V
V
D
F
C
H
S
Q
D
C
S
V
E
A
E
L
G
R
L
G
S
-------------AF
L
-
T
----
D
P
Q
E
---
A
K
R
F
-
V
E
-
L
T
----
G
V
D
S
L
A
V
A
I
G
T
A
H
G
-
L
Y
S
--
K
-
T
P
-
K
--
I
D
F
Q
R
--
L
A
E
I
R
E
V
----------
V
---D
V
P
L
V
L
H
G
A
S
---------------------
D
V
P
---------------------
D
---------------------
E
---------------------
F
---------------------
V
R
R
T
I
E
L
G
V
T
K
V
N
V
A
T
E
L
K
I
A
F
A
G
A
V
K
A
W
F
A
E
N
P
--------------
Q
G
N
D
P
R
Y
Y
M
R
V
G
M
D
A
M
K
E
V
V
R
N
K
I
N
V
C
G
S
A
N
R
I
S
36
PsiBlast_CBE
84.21
35%
-85
- C1 -
3N9R
4
?
B:
[2-306]
----
L
V
K
---
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
----
I
D
M
---
A
-------
V
G
M
V
K
I
M
C
E
R
Y
-
P
-
H
-
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
--------------
C
E
K
A
----
V
K
A
---
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
----------------
A
VLVN
P
K
E
A
---
E
Q
F
V
-
K
E
-
S
-----
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
-
G
E
P
K
--
L
D
F
E
R
--
L
Q
E
V
K
R
-----------
L
T
N
I
--
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
---------------------
V
RKSYLDAGGDLKGSKGVPFEF
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
--------------
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
31
PsiBlast_CBE
83.99
35%
-83
- C1 -
3N9S
5
?
B:
[2-306]
----
L
V
K
---
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
----
I
D
M
---
A
-------
V
G
M
V
K
I
M
C
E
R
Y
-
P
-
H
-
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
--------------
C
E
K
A
----
V
K
A
---
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
------------------
A
VLVN
P
K
E
A
---
E
Q
F
V
-
K
E
-
S
-----
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
-
G
E
P
K
--
L
D
F
E
R
--
L
Q
E
V
K
R
-----------
L
T
N
I
--
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
---------------------
V
R
K
S
Y
L
D
A
GGDLKGSKGVP
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
--------------
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
37
PsiBlast_CBE
83.78
35%
-86
- C1 -
3C56
3
ALF_HELPY
B:
[2-306]
----
L
V
K
---
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
----
I
D
M
---
A
-------
V
G
M
V
K
I
M
C
E
R
Y
-
P
-
H
-
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
--------------
C
E
K
A
----
V
K
A
---
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
-------------------VLVN
P
K
E
A
---
E
Q
F
V
-
K
E
-
S
-----
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
-
G
E
P
K
--
L
D
F
E
R
--
L
Q
E
V
K
R
-----------
L
T
N
I
--
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
---------------------
V
R
K
S
Y
L
D
A
GGDLKGSKGVP
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
--------------
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
11
PsiBlast_PDB
82.51
35%
-82
- C1 -
3C52
4
ALF_HELPY
A:
[2-306]
----
L
V
K
---
G
N
E
I
L
L
K
A
H
K
E
G
Y
G
V
G
A
F
N
F
V
N
F
E
M
L
N
A
I
F
E
A
G
N
E
E
N
S
P
L
F
I
Q
A
S
E
G
A
I
K
Y
M
G
----
I
D
M
---
A
-------
V
G
M
V
K
I
M
C
E
R
Y
-
P
-
H
-
I
P
V
A
L
H
L
D
H
G
-
T
T
F
E
S
--------------
C
E
K
A
----
V
K
A
---
G
F
T
S
V
M
I
D
A
S
H
H
A
F
E
E
N
L
E
L
T
S
K
V
V
K
M
A
H
N
A
G
V
S
V
E
A
E
L
G
R
L
M
G
I
-----------------VLVN
P
K
E
A
---
E
Q
F
V
-
K
E
-
S
-----
Q
V
D
Y
L
A
P
A
I
G
T
S
H
G
A
F
K
F
--
K
-
G
E
P
K
--
L
D
F
E
R
--
L
Q
E
V
K
R
-----------
L
T
N
I
--
P
L
V
L
H
G
A
S
---------------------
A
I
P
---------------------
D
---------------------
N
---------------------
V
R
K
S
Y
L
D
A
G
G
D
L
K
GSKGVP
F
E
F
L
Q
E
S
V
K
G
G
I
N
K
V
N
T
D
T
D
L
R
I
A
F
I
A
E
V
R
K
V
A
N
E
--------------
D
K
S
Q
F
D
L
R
K
F
F
S
P
A
Q
L
A
L
K
N
V
V
K
E
R
M
K
L
L
G
S
A
N
K
I
-
43
HHSearch
73.97
31%
-72
- C1 -
3ELF
3
ALF_MYCTU
A:
[2-341]
---
P
I
A
T
P
E
V
Y
A
E
M
L
G
Q
A
K
Q
N
S
Y
A
F
P
A
I
N
C
T
S
S
E
T
V
N
A
A
I
K
G
F
A
D
A
G
S
D
G
I
I
Q
F
S
T
G
G
A
E
F
G
S
G
LG-
V
K
D
---
M
V
T
G
A
V
A
L
A
E
F
T
H
V
I
--
A
A
-
K
Y
P
-
V
N
V
A
L
H
T
D
H
C
P
K
-
D
K
L
DSY
V
R
P
L
L
A
I
S
A
Q
R
V
S
K
G
----
G
N
P
---
L
F
Q
S
H
M
W
D
G
S
A
V
P
I
D
E
N
L
A
I
A
Q
E
L
L
K
A
A
A
A
A
K
I
I
L
E
I
E
I
G
V
V
G
G
---------------
Y
-
T
----
S
P
E
D
---
F
E
K
T
I
E
A
-
L
GAGEH
G
K
Y
L
L
A
A
T
F
G
N
V
H
G
V
Y
K
P
--
G
-
N
V
-
K
--
L
R
P
D
I
--
L
A
Q
G
Q
Q
V
A
A
A
K
L
GLPAD
A
K
P
F
--
D
F
V
F
H
G
G
S
---------------------
G
S
L
---------------------
K
---------------------
S
---------------------
E
---------------------
I
E
E
A
L
R
Y
G
V
V
K
M
N
V
D
T
D
T
Q
Y
A
F
T
R
P
I
A
G
H
M
F
T
N
-
Y
D
G
V
LKVDG
E
V
G
V
K
K
V
Y
D
P
R
S
Y
L
K
K
A
E
A
S
M
S
Q
R
V
V
Q
A
C
N
D
L
H
C
A
G
K
S
-