@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0126: (2015-11-28 )
MTRKIGIIGMGHVGSTVAHALIAQGIGDDYVFIDTNIDKVNADMIDFQDALANATYHANIVLNDYDALSDADVVISALGDISLQNNKEANRFAELPFTSKEVYDVSQKLKSSGFRGILIVVTNPVDAITQLYQEYTQFPKSRVIGTGTLLDTARMKRVLGQRLQVDPRSIGGYNLGEHGNSQFVAWSQVTVKGQPAISLLKAEELEQIKEASLKGGHTVFFGKKYTSYGIATAAVRIVLAVLNDSHELLPVSTFYESEGVYLGYPAIIGRVGIVERISLSLSPKEEQQLTDSAAFIRNYLKHINL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80..--.-.....90........100-.-.-.....110.......120.......130.......140.......150.......160.......170.......180.......190.......------200----....----..--...210.--------......220.......230.......240.......250..----....----.260.......270.......280.......290.......300...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
R
K
I
G
I
I
G
MG
H
V
G
S
T
V
A
H
A
L
I
A
QGIGD
D
Y
V
F
I
DTNIDKVNA
D
M
I
D
F
Q
D
A
LAN
A
T
Y
H
A
N
I
V
L
NDYDALS
D
A
D
V
V
I
S
A
L
GDISL--Q-NNKEANRFAELPF
T
S
K
E
V
-
Y
-
D
-
V
S
Q
K
L
K
SSGF
R
G
I
L
I
V
VTN
P
V
D
A
I
T
Q
L
Y
Q
E
Y
T
QFPKSRVIGT
G
T
L
L
D
T
A
R
M
K
R
V
L
G
Q
RLQVDPRSIGGYNLGEHGNS
Q
F
V
A
W
S
Q
V
T
VKGQP
A
I
S
L
------
L
------
K
A
E
E
----
L
E
--
Q
I
K
E
A
SL--------KGG
H
T
V
F
FGKKYTSY
G
I
A
T
A
A
V
R
I
V
L
A
V
LNDSHEL
L
P
V
S
T
F
----YESE----
G
V
Y
LG
Y
P
A
I
I
G
RVG
I
V
E
R
I
S
LSLSP
K
E
E
Q
Q
L
T
D
S
A
A
F
I
R
N
Y
L
K
HINL
22
PsiBlast_CBE
98.18
57%
-117
- C3 -
1HYH
2
DHL2_WEICO
C:
[2-305]
--
R
K
I
G
I
I
G
L
G
N
V
G
A
A
V
A
H
G
L
I
A
Q
G
V
A
D
D
Y
V
F
I
D
A
N
E
A
K
V
K
A
D
Q
I
D
F
Q
D
A
M
A
N
L
E
A
H
G
N
I
V
I
N
D
W
A
A
L
A
D
A
D
V
V
I
S
T
L
G
------------
G
D
R
F
A
E
L
K
F
T
S
S
M
V
-
Q
-
S
-
V
G
T
N
L
K
E
S
G
F
H
G
V
L
V
V
I
S
N
P
V
D
V
I
T
A
L
F
Q
H
V
T
G
F
P
A
H
K
V
I
G
T
G
T
L
L
D
T
A
R
M
Q
R
A
V
G
E
A
F
D
L
D
P
R
S
V
S
G
Y
N
L
G
E
H
G
N
S
Q
F
V
A
W
S
T
V
R
V
M
G
Q
P
I
V
T
L
------
A
------
D
A
------
I
D
LA
A
I
E
E
E
A
R
--------
K
G
G
F
T
V
L
N
G
K
G
Y
T
S
Y
G
V
A
T
S
A
I
R
I
A
K
A
V
M
A
D
A
H
A
E
L
V
V
S
N
R
----
R
D
D
M
----
G
M
Y
L
S
Y
P
A
I
I
G
R
D
G
V
L
A
E
T
T
L
D
L
T
T
D
E
Q
E
K
L
L
Q
S
R
D
Y
I
Q
Q
R
F
D
E
I
V
D
21
PsiBlast_CBE
95.57
57%
-115
- C3 -
1HYH
2
DHL2_WEICO
D:
[2-305]
--
R
K
I
G
I
I
G
L
G
N
V
G
A
A
V
A
H
G
L
I
A
Q
G
V
A
D
D
Y
V
F
I
D
A
N
E
A
K
V
K
A
D
Q
I
D
F
Q
D
A
M
A
N
L
E
A
H
G
N
I
V
I
N
D
W
A
A
L
A
D
A
D
V
V
I
S
T
L
G
------------
G
D
R
F
A
E
L
K
F
T
S
S
M
V
-
Q
-
S
-
V
G
T
N
L
K
E
S
G
F
H
G
V
L
V
V
I
S
N
P
V
D
V
I
T
A
L
F
Q
H
V
T
G
F
P
A
H
K
V
I
G
T
G
T
L
L
D
T
A
R
M
Q
R
A
V
G
E
A
F
D
L
D
P
R
S
V
S
G
Y
N
L
G
E
H
G
N
S
Q
F
V
A
W
S
T
V
R
V
M
G
Q
P
I
V
T
L
------
A
------
D
A
------
I
D
LA
A
I
E
E
E
A
R
--------
K
G
G
F
T
V
L
N
G
K
G
Y
T
S
Y
G
V
A
T
S
A
I
R
I
A
K
A
V
M
A
D
A
H
A
E
L
V
V
S
N
R
----
R
D
D
M
----
G
M
Y
L
S
Y
P
A
I
I
G
R
D
G
V
L
A
E
T
T
L
D
L
T
T
D
E
Q
E
K
L
L
Q
S
R
D
Y
I
Q
Q
R
F
D
E
I
V
D
23
PsiBlast_CBE
92.05
57%
-109
- C3 -
1HYH
2
DHL2_WEICO
B:
[2-305]
--
R
K
I
G
I
I
G
L
G
N
V
G
A
A
V
A
H
G
L
I
A
Q
G
V
A
D
D
Y
V
F
I
D
A
N
E
A
K
V
K
A
D
Q
I
D
F
Q
D
A
M
A
N
L
E
A
H
G
N
I
V
I
N
D
W
A
A
L
A
D
A
D
V
V
I
S
T
L
G
N
I
K
L
--
Q
Q
-------
F
A
E
L
K
F
T
S
S
M
V
-
Q
-
S
-
V
G
T
N
L
K
E
S
G
F
H
G
V
L
V
V
I
S
N
P
V
D
V
I
T
A
L
F
Q
H
V
T
G
F
P
A
H
K
V
I
G
T
G
T
L
L
D
T
A
R
M
Q
R
A
V
G
E
A
F
D
L
D
P
R
S
V
S
G
Y
N
L
G
E
H
G
N
S
Q
F
V
A
W
S
T
V
R
V
M
G
Q
P
I
V
T
L
---------------------
I
D
L
A
A
I
E
E
E
A
R
--------
K
G
G
F
T
V
L
N
G
K
G
Y
T
S
Y
G
V
A
T
S
A
I
R
I
A
K
A
V
M
A
D
A
H
A
E
L
V
V
S
N
R
----
R
D
D
M
----
G
M
Y
L
S
Y
P
A
I
I
G
R
D
G
V
L
A
E
T
T
L
D
L
T
T
D
E
Q
E
K
L
L
Q
S
R
D
Y
I
Q
Q
R
F
D
E
I
V
-
1
PsiBlast_PDB
90.55
57%
-110
- C3 -
1HYH
2
DHL2_WEICO
A:
[2-305]
--
R
K
I
G
I
I
G
L
G
N
V
G
A
A
V
A
H
G
L
I
A
Q
G
V
A
D
D
Y
V
F
I
D
A
N
E
A
K
V
K
A
D
Q
I
D
F
Q
D
A
M
A
N
L
E
A
H
G
N
I
V
I
N
D
W
A
A
L
A
D
A
D
V
V
I
S
T
L
G
N
I
K
L
--
Q
Q-------
F
A
E
L
K
F
T
S
S
M
V
-
Q
-
S
-
V
G
T
N
L
K
E
S
G
F
H
G
V
L
V
V
I
S
N
P
V
D
V
I
T
A
L
F
Q
H
V
T
G
F
P
A
H
K
V
I
G
T
G
T
L
L
D
T
A
R
M
Q
R
A
V
G
E
A
F
D
L
D
P
R
S
V
S
G
Y
N
L
G
E
H
G
N
S
Q
F
V
A
W
S
T
V
R
V
M
G
Q
P
I
V
T
L
---------------------
I
D
L
A
A
I
E
E
E
A
R
--------
K
G
G
F
T
V
L
N
G
K
G
Y
T
S
Y
G
V
A
T
S
A
I
R
I
A
K
A
V
M
A
D
A
H
A
E
L
V
V
S
N
R
----
R
D
D
M
----
G
M
Y
L
S
Y
P
A
I
I
G
R
D
G
V
L
A
E
T
T
L
D
L
T
T
D
E
Q
E
K
L
L
Q
S
R
D
Y
I
Q
Q
R
F
D
E
I
V
D
113
HHSearch
89.47
57%
-108
- C3 -
1HYH
2
DHL2_WEICO
A:
[1-306]
-
A
R
K
I
G
I
I
G
L
G
N
V
G
A
A
V
A
H
G
L
I
A
Q
G
V
A
D
D
Y
V
F
I
D
A
N
E
A
K
V
K
A
D
Q
I
D
F
Q
D
A
M
A
N
L
E
A
H
G
N
I
V
I
N
D
W
A
A
L
A
D
A
D
V
V
I
S
T
L
G
N
I
K
L
QQ---------
F
A
E
L
K
F
T
S
S
M
V
-
Q
-
S
-
V
G
T
N
L
K
E
S
G
F
H
G
V
L
V
V
I
S
N
P
V
D
V
I
T
A
L
F
Q
H
V
T
G
F
P
A
H
K
V
I
G
T
G
T
L
L
D
T
A
R
M
Q
R
A
V
G
E
A
F
D
L
D
P
R
S
V
S
G
Y
N
L
G
E
H
G
N
S
Q
F
V
A
W
S
T
V
R
V
M
G
Q
P
I
V
T
L
---------------
I
D
----
L
A
--
A
I
E
E
E
A
R
--------
K
G
G
F
T
V
L
N
G
K
G
Y
T
S
Y
G
V
A
T
S
A
I
R
I
A
K
A
V
M
A
D
A
H
A
E
L
V
V
S
N
R
----
R
D
D
M
----
G
M
Y
L
S
Y
P
A
I
I
G
R
D
G
V
L
A
E
T
T
L
D
L
T
T
D
E
Q
E
K
L
L
Q
S
R
D
Y
I
Q
Q
R
F
D
E
I
V
D
29
PsiBlast_CBE
83.91
34%
-105
- C3 -
3WSV
3
?
B:
[5-315]
-
S
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
E
K
N
V
S
V
W
S
G
T
Y
E
E
C
Q
D
A
N
L
V
I
L
T
A
G
------
V
-
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
-
Q
-
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
V
EKDHR
L
------
E
E
N
D
----
L
T
--
V
L
A
D
K
V
K
--------
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
LNGE
Y
G
E
E
----
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
T
V
R
L
30
PsiBlast_CBE
83.34
34%
-107
- C3 -
3PQF
1
LDH_BACSU
D:
[6-311]
--
N
K
V
A
L
I
G
A
G
F
V
G
S
S
Y
A
F
A
L
I
N
Q
G
I
T
D
E
L
V
V
I
D
V
N
K
E
K
A
M
G
D
V
M
D
L
N
H
G
K
A
F
A
P
Q
P
V
K
T
S
Y
G
T
Y
E
D
C
K
D
A
D
I
V
C
I
C
A
G
------
A
-
N
Q
K
P
G
E
T
R
L
E
L
V
E
K
N
L
K
I
-
F
-
K
G
I
V
S
E
V
M
A
S
G
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
T
L
D
S
A
R
F
R
F
M
L
S
E
Y
F
G
A
A
P
Q
N
V
C
A
H
I
I
G
E
H
G
D
T
E
L
P
V
W
S
H
A
N
V
G
G
V
P
V
S
E
L
------
V
EKNDAY
K
Q
E
E
----
L
D
--
Q
I
V
D
D
V
K
--------
N
A
A
Y
H
I
I
E
K
K
G
A
T
Y
Y
G
V
A
M
S
L
A
R
I
T
K
A
I
L
H
N
E
N
S
I
L
T
V
S
T
Y
LDGQ
Y
G
A
D
----
D
V
Y
I
G
V
P
A
V
V
N
R
G
G
I
A
G
I
T
E
L
N
L
N
E
K
E
K
E
Q
F
L
H
S
A
G
V
L
K
N
I
L
K
P
H
F
-
2
PsiBlast_PDB
83.34
34%
-103
- C3 -
3WSV
2
?
A:
[5-315]
-
S
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
-----
L
D
G
M
A
W
G
E
K
N
V
S
V
W
S
G
T
Y
E
E
C
Q
D
A
N
L
V
I
L
T
A
G
------
V
-
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
-
Q
-
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
V
E
KDHR
L
------
E
E
N
D
----
L
T
--
V
L
A
D
K
V
K
--------
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
LNGE
Y
G
E
E
----
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
T
V
R
L
33
PsiBlast_CBE
83.08
34%
-106
- C3 -
3PQD
1
LDH_BACSU
G:
[6-311]
--
N
K
V
A
L
I
G
A
G
F
V
G
S
S
Y
A
F
A
L
I
N
Q
G
I
T
D
E
L
V
V
I
D
V
N
K
E
K
A
M
G
D
V
M
D
L
N
H
G
K
A
F
A
P
Q
P
V
K
T
S
Y
G
T
Y
E
D
C
K
D
A
D
I
V
C
I
C
A
------------------
E
L
V
E
K
N
L
K
I
-
F
-
K
G
I
V
S
E
V
M
A
S
G
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
T
L
D
S
A
R
F
R
F
M
L
S
E
Y
F
G
A
A
P
Q
N
V
H
A
H
I
I
G
E
H
G
D
T
E
L
P
V
W
S
H
A
N
V
G
G
V
P
V
S
E
L
------
V
EKNDAY
K
Q
E
E
----
L
D
--
Q
I
V
D
D
V
K
--------
N
A
A
Y
H
I
I
E
K
K
G
A
T
Y
Y
G
V
A
M
S
L
A
R
I
T
K
A
I
L
H
N
E
N
S
I
L
T
V
S
T
Y
LDGQ
Y
G
A
D
----
D
V
Y
I
G
V
P
A
V
V
N
R
G
G
I
A
G
I
T
E
L
N
L
N
E
K
E
K
E
Q
F
L
H
S
A
G
V
L
K
N
I
L
K
P
H
F
-
24
PsiBlast_CBE
82.78
34%
-105
- C3 -
3WSW
5
?
D:
[5-315]
-
S
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
E
K
N
V
S
V
W
S
G
T
Y
E
E
C
Q
D
A
N
L
V
I
L
T
A
G
------
V
-
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
-
Q
-
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
VEKDHR
L
------
E
E
N
D
----
L
T
--
V
L
A
D
K
V
K
--------
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
LNGE
Y
G
E
E
----
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
T
V
R
L
25
PsiBlast_CBE
82.67
34%
-107
- C3 -
3WSW
6
?
C:
[5-315]
-
S
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
E
K
N
V
S
V
W
S
G
T
Y
E
E
C
Q
D
A
N
L
V
I
L
T
A
G
------
V
-
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
-
Q
-
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
VEKDHR
L
------
E
E
N
D
----
L
T
--
V
L
A
D
K
V
K
--------
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
LNGE
Y
G
E
E
----
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
T
V
R
L
49
PsiBlast_CBE
82.62
34%
-106
- C3 -
1LDN
2
LDH_GEOSE
E:
[8-311]
---
R
V
V
V
I
G
A
G
F
V
G
A
S
Y
V
F
A
L
M
N
Q
G
I
A
D
E
I
V
L
I
D
A
N
E
S
K
A
I
G
D
A
M
D
F
N
H
G
K
V
F
A
P
K
P
V
D
I
W
H
G
D
Y
D
D
C
R
D
A
D
L
V
V
I
C
A
G
------
A
-
N
Q
K
P
G
E
T
R
L
D
L
V
D
K
N
I
A
I
-
F
R
S
-
I
V
E
S
V
M
A
S
G
F
Q
G
L
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
H
E
R
V
I
G
S
G
T
I
L
D
T
A
R
F
R
F
L
L
G
E
Y
F
S
V
A
P
Q
N
V
H
A
Y
I
I
G
E
H
G
D
T
E
L
P
V
W
S
Q
A
Y
I
G
V
M
P
I
R
K
L
------
V
ES----
K
G
E
E
AQKD
L
E
--
R
I
F
V
N
V
R
--------
D
A
A
Y
Q
I
I
E
K
K
G
A
T
Y
Y
G
I
A
M
G
L
A
R
V
T
R
A
I
L
H
N
E
N
A
I
L
T
V
S
A
Y
LDGL
Y
G
E
R
----
D
V
Y
I
G
V
P
A
V
I
N
R
N
G
I
R
E
V
I
E
I
E
L
N
D
D
E
K
N
R
F
H
H
S
A
A
T
L
K
S
V
L
A
R
A
F
T
27
PsiBlast_CBE
82.52
34%
-105
- C3 -
3WSV
2
?
D:
[5-315]
-
S
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
E
K
N
V
S
V
W
S
G
T
Y
E
E
C
Q
D
A
N
L
V
I
L
T
A
G
------
V
-
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
-
Q
-
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
VEKDHR
L
------
E
E
N
D
----
L
T
--
V
L
A
D
K
V
K
--------
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
LNGE
Y
G
E
E
----
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
T
V
R
L
11
PsiBlast_PDB
82.43
34%
-112
- C3 -
3VKU
2
LDH_LACCA
A:
[10-312]
--
Q
K
V
I
L
V
G
D
G
A
V
G
S
S
Y
A
Y
A
M
V
L
Q
G
I
A
Q
E
I
G
I
V
D
I
F
K
D
K
T
K
G
D
A
I
D
L
E
D
A
L
P
-
F
T
S
P
K
K
I
Y
S
A
E
Y
S
D
A
K
D
A
D
L
V
V
I
T
A
G
--
A
P
--------------------
I
L
-
K
-
S
-
I
V
D
P
I
V
D
S
G
F
N
G
I
F
L
V
A
A
N
P
V
D
I
L
T
Y
A
T
W
K
L
S
G
F
P
K
N
R
V
V
G
S
G
T
S
L
D
T
A
R
F
R
Q
S
I
A
K
M
V
N
V
D
A
R
S
V
H
A
Y
I
M
G
E
H
G
D
T
E
F
P
V
W
S
H
A
N
I
G
G
V
T
I
A
E
W
------
V
------
K
A
H
------
P
--
E
I
K
E
D
K
L
V
K
M
F
E
D
V
R
N
K
A
Y
E
I
I
K
L
K
G
A
T
F
Y
G
I
A
T
A
L
A
R
I
S
K
A
I
L
N
D
E
N
A
V
L
P
L
S
V
Y
----
M
D
G
Q
YGLN
D
I
Y
I
G
T
P
A
V
I
N
R
N
G
I
Q
N
I
L
E
I
P
L
T
D
H
E
E
E
S
M
Q
K
S
A
S
Q
L
K
K
V
------
6
PsiBlast_PDB
82.00
34%
-106
- C3 -
3PQD
1
LDH_BACSU
A:
[6-311]
--
N
K
V
A
L
I
G
A
G
F
V
G
S
S
Y
A
F
A
L
I
N
Q
G
I
T
D
E
L
V
V
I
D
V
N
K
E
K
A
M
G
D
V
M
D
L
N
H
G
K
A
F
A
P
Q
P
V
K
T
S
Y
G
T
Y
E
D
C
K
D
A
D
I
V
C
I
C
A
G
------
A
-
N
Q
K
P
G
E
T
R
L
E
L
V
E
K
N
L
K
I
-
F
-
K
G
I
V
S
E
V
M
A
S
G
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
T
L
D
S
A
R
F
R
F
M
L
S
E
Y
F
G
A
A
P
Q
N
V
H
A
H
I
I
G
E
H
G
D
T
E
L
P
V
W
S
H
A
N
V
G
G
V
P
V
S
E
L
------
V
EKNDAY
K
Q
E
E
----
L
D
--
Q
I
V
D
D
V
K
--------
N
A
A
Y
H
I
I
E
K
K
G
A
T
Y
Y
G
V
A
M
S
L
A
R
I
T
K
A
I
L
H
N
E
N
S
I
L
T
V
S
T
Y
L
DGQ
Y
G
A
D
----
D
V
Y
I
G
V
P
A
V
V
N
R
G
G
I
A
G
I
T
E
L
N
L
N
E
K
E
K
E
Q
F
L
H
S
A
G
V
L
K
N
I
L
K
P
---
36
PsiBlast_CBE
81.67
34%
-110
- C3 -
3PQD
2
LDH_BACSU
D:
[6-311]
--
N
K
V
A
L
I
G
A
G
F
V
G
S
S
Y
A
F
A
L
I
N
Q
G
I
T
D
E
L
V
V
I
D
V
N
K
E
K
A
M
G
D
V
M
D
L
N
H
G
K
A
F
A
P
Q
P
V
K
T
S
Y
G
T
Y
E
D
C
K
D
A
D
I
V
C
I
C
A
-----------------
L
E
L
V
E
K
N
L
K
I
-
F
-
K
G
I
V
S
E
V
M
A
S
G
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
T
L
D
S
A
R
F
R
F
M
L
S
E
Y
F
G
A
A
P
Q
N
V
H
A
H
I
I
G
E
H
G
D
T
E
L
P
V
W
S
H
A
N
V
G
G
V
P
V
S
E
L
------
V
EKNDAY
K
Q
E
E
----
L
D
--
Q
I
V
D
D
V
K
--------
N
A
A
Y
H
I
I
E
K
K
G
A
T
Y
Y
G
V
A
M
S
L
A
R
I
T
K
A
I
L
H
N
E
N
S
I
L
T
V
S
T
Y
L
D
GQ
Y
G
A
D
----
D
V
Y
I
G
V
P
A
V
V
N
R
G
G
I
A
G
I
T
E
L
N
L
N
E
K
E
K
E
Q
F
L
H
S
A
G
V
L
K
N
I
L
K
P
H
F
-
37
PsiBlast_CBE
81.53
34%
-107
- C3 -
3PQD
1
LDH_BACSU
C:
[6-311]
--
N
K
V
A
L
I
G
A
G
F
V
G
S
S
Y
A
F
A
L
I
N
Q
G
I
T
D
E
L
V
V
I
D
V
N
K
E
K
A
M
G
D
V
M
D
L
N
H
G
K
A
F
A
P
Q
P
V
K
T
S
Y
G
T
Y
E
D
C
K
D
A
D
I
V
C
I
C
A
G
---------------
R
L
E
L
V
E
K
N
L
K
I
-
F
-
K
G
I
V
S
E
V
M
A
S
G
F
D
G
I
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
K
E
R
V
I
G
S
G
T
T
L
D
S
A
R
F
R
F
M
L
S
E
Y
F
G
A
A
P
Q
N
V
H
A
H
I
I
G
E
H
G
D
T
E
L
P
V
W
S
H
A
N
V
G
G
V
P
V
S
E
L
------
V
E
K
NDAY
K
Q
E
E
----
L
D
--
Q
I
V
D
D
V
K
--------
N
A
A
Y
H
I
I
E
K
K
G
A
T
Y
Y
G
V
A
M
S
L
A
R
I
T
K
A
I
L
H
N
E
N
S
I
L
T
V
S
T
Y
L
DGQ
Y
G
A
D
----
D
V
Y
I
G
V
P
A
V
V
N
R
G
G
I
A
G
I
T
E
L
N
L
N
E
K
E
K
E
Q
F
L
H
S
A
G
V
L
K
N
I
L
K
P
---
46
PsiBlast_CBE
81.46
34%
-103
- C3 -
1LDN
2
LDH_GEOSE
H:
[8-311]
---
R
V
V
V
I
G
A
G
F
V
G
A
S
Y
V
F
A
L
M
N
Q
G
I
A
D
E
I
V
L
I
D
A
N
E
S
K
A
I
G
D
A
M
D
F
N
H
G
K
V
F
A
P
K
P
V
D
I
W
H
G
D
Y
D
D
C
R
D
A
D
L
V
V
I
C
A
G
------
A
-
N
Q
K
P
G
E
T
R
L
D
L
V
D
K
N
I
A
I
-
F
R
S
-
I
V
E
S
V
M
A
S
G
F
Q
G
L
F
L
V
A
T
N
P
V
D
I
L
T
Y
A
T
W
K
F
S
G
L
P
H
E
R
V
I
G
S
G
T
I
L
D
T
A
R
F
R
F
L
L
G
E
Y
F
S
V
A
P
Q
N
V
H
A
Y
I
I
G
E
H
G
D
T
E
L
P
V
W
S
Q
A
Y
I
G
V
M
P
I
R
K
L
------
V
ES----
K
G
E
E
AQKD
L
E
--
R
I
F
V
N
V
R
--------
D
A
A
Y
Q
I
I
E
K
K
G
A
T
Y
Y
G
I
A
M
G
L
A
R
V
T
R
A
I
L
H
N
E
N
A
I
L
T
V
S
A
Y
LDGL
Y
G
E
R
----
D
V
Y
I
G
V
P
A
V
I
N
R
N
G
I
R
E
V
I
E
I
E
L
N
D
D
E
K
N
R
F
H
H
S
A
A
T
L
K
S
V
L
A
R
A
F
T
3
PsiBlast_PDB
81.34
34%
-108
- C3 -
3WSW
5
?
A:
[5-315]
-
S
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
E
K
N
V
S
V
W
S
G
T
Y
E
E
C
Q
D
A
N
L
V
I
L
T
A
G
------
V
-
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
-
Q
-
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
V
EKDHR
L
------
E
E
N
D
----
L
T
--
V
L
A
D
K
V
K
--------
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
L
NGE
Y
G
E
E
----
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
T
V
R
L
26
PsiBlast_CBE
81.24
34%
-103
- C3 -
3WSW
4
?
B:
[5-315]
-
S
R
K
V
V
I
V
G
T
G
F
V
G
T
S
I
A
Y
A
M
I
N
Q
G
V
A
N
E
L
V
L
I
D
V
N
Q
E
K
A
E
G
E
A
L
D
L
L
D
G
M
A
W
G
E
K
N
V
S
V
W
S
G
T
Y
E
E
C
Q
D
A
N
L
V
I
L
T
A
G
------
V
-
N
Q
K
P
G
Q
T
R
L
D
L
V
K
T
N
A
T
I
T
R
-
Q
-
I
V
K
E
V
M
A
S
G
F
D
G
I
F
V
V
A
S
N
P
V
D
I
L
T
Y
L
T
W
Q
E
S
G
L
P
A
S
R
V
V
G
T
G
T
T
L
D
T
T
R
F
R
K
E
I
A
L
K
L
A
V
D
P
R
S
V
H
G
Y
I
L
G
E
H
G
D
S
E
V
A
A
W
S
H
T
T
V
G
G
K
P
I
M
E
Y
VEKDHR
L
------
E
E
N
D
----
L
T
--
V
L
A
D
K
V
K
--------
N
A
A
Y
E
I
I
D
R
K
K
A
T
Y
Y
G
I
G
M
S
T
T
R
I
V
K
A
I
L
N
N
E
Q
A
V
L
P
V
S
A
Y
LNGE
Y
G
E
E
----
D
I
F
T
G
V
P
S
I
V
D
E
N
G
V
R
E
I
I
D
L
S
I
T
P
Q
E
K
A
M
F
H
Q
S
V
S
E
L
K
A
V
L
D
T
V
R
L