@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0147: (2015-11-28 )
MEKETILSVNNLHVDFHTYAGEVKAIRDVNFELKKGETLAIVGESGSGKSVTTRTLIGLNAKNSEISGNVQFKGRNLVELSEEEWTKVRGNEISMIFQDPMTSLDPTMKIGMQIAEPMMIHQKISKKDALKLALELMKDVGIPNAEEHINDYPHQWSGGMRQRAVIAIALAADPEILIADEPTTALDVTIQAQILNLMKKIQAERDSSIVFITHDLGVVAGMADRVAVMYAGKIVEFGTVDEVFYNPQHPYTWGLLNSMPTTDTESGSLESIPGTPPDLLNPPKGDAFAARNEFALDIDHEEEPPYFKVSETHFAATWLLDERSPKVLPPLPIQKRWEKWNEIEGRKA
Atome Classification :
(34 SA)
.........10........20--.........30........40........50........60.....-...70........80........90........100.......110.......120-.......130..-.....140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.....-------------..280.......290.......300.......310.......320.......330.......340......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEK
E
T
I
L
S
V
N
N
L
H
V
D
F
H
TYA---G
E
V
K
A
I
R
D
V
N
F
E
LKKG
E
T
L
A
I
V
GESGSGK
S
V
T
T
R
T
L
I
G
LNAKNSEI-S
G
N
V
Q
F
KGR
N
L
V
ELSE
E
E
W
T
KVRG
N
E
I
S
M
I
F
QDPMTSLD
P
T
M
K
I
G
M
Q
IA
E
P
M
M
I
H
Q
-KI
S
K
K
D
A
L
K
L
A
L
-
E
L
M
K
DVGIP
N
A
E
E
H
I
NDYPHQWSGGM
R
Q
R
A
V
I
A
I
A
LAAD
P
E
I
L
I
ADEPT
T
A
L
D
V
T
I
Q
A
Q
I
L
N
L
M
K
K
I
Q
AERDS
S
I
V
F
I
THD
L
G
V
V
A
G
M
A
D
R
V
A
V
M
YAG
K
I
VEFG
T
V
D
E
VFYNPQHPY
T
W
G
LLNSMPTTDTESGSLESIPGTPP-------------DLLNPPKGDAFAARN
E
F
A
L
DIDHEEEPP
Y
F
K
V
SE
T
H
F
A
A
T
W
L
LDERSPKVLPPL
P
I
Q
K
R
W
E
K
W
NEIEGRKA
1
PsiBlast_PDB
93.73
38%
-99
- C1 -
4FWI
3
?
B:
[4-321]
-----
I
I
R
V
E
D
L
R
A
V
Y
L
V
R
E
---
G
T
I
K
A
A
D
G
I
S
L
D
I
L
E
N
S
V
T
A
I
V
G
E
S
A
S
G
K
S
T
I
I
E
A
M
T
K
T
L
P
P
N
G
R
I
L
S
G
R
V
L
Y
K
G
K
D
L
L
T
M
R
E
E
E
L
R
K
I
R
W
K
E
I
A
L
V
P
Q
A
A
Q
Q
S
L
N
P
T
M
K
V
I
E
H
F
K
D
T
V
E
A
H
G
V
R
W
S
H
S
E
L
I
E
K
A
S
-
E
K
L
R
M
V
R
L
-
N
P
E
A
V
L
N
S
Y
P
L
Q
L
S
G
G
M
K
Q
R
V
L
I
A
L
A
L
L
L
D
P
V
V
L
I
L
D
E
P
T
S
A
L
D
V
L
T
Q
A
H
I
I
Q
L
L
K
E
L
K
K
M
L
K
I
T
L
I
F
V
T
H
D
I
A
V
A
A
E
L
A
D
K
V
A
V
I
Y
G
G
N
L
V
E
Y
N
S
T
F
Q
I
F
K
N
P
L
H
P
Y
T
R
G
L
I
N
S
I
M
----------
P
I
P
G
D
P
P
-------------
S
L
L
N
P
P
S
G
C
R
F
H
P
R
C
E
Y
A
M
E
I
C
K
K
E
K
P
K
W
I
R
L
D
G
E
A
H
V
A
C
H
L
Y
E
E
--------------------------
76
HHSearch
77.27
33%
-109
- C1 -
3TUI
1
METN_ECOLI
C:
[23-267]
----
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
---
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
---
T
-
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
-
A
R
R
Q
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
--
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
L
G
---
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
-------------
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
68
Fugue
77.20
27%
-83
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
----
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
---
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
----
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
--
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
-
T
-
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
L
G
D
K
H
---
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
TDCVPMLRLEFTG
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
--
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
-----
33
PsiBlast_CBE
75.71
32%
-102
- C1 -
3C4J
4
?
B:
[25-262]
-------------
I
D
V
H
Q
L
K
KSF
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
---
N
L
L
E
D
F
D
-
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.27
33%
-103
- C1 -
3TUZ
1
METN_ECOLI
C:
[24-266]
-----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
---
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
---
N
L
L
E
R
P
T
-
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
---
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
--
G
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
-------------
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
13
PsiBlast_PDB
74.76
33%
-99
- C1 -
4YMV
1
?
J:
[1-239]
-----
M
I
F
V
N
D
V
Y
K
N
F
-------
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
---
N
L
L
E
E
P
T
-
K
G
E
V
F
I
D
G
V
K
-
I
N
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
---
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-----------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
74.46
32%
-98
- C1 -
3C41
3
?
K:
[4-241]
-------------
I
D
V
H
Q
L
K
KSF
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
---
N
L
L
E
D
F
D
-
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
74.44
33%
-101
- C1 -
3TUI
1
METN_ECOLI
H:
[24-266]
-----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
---
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
---
N
L
L
E
R
P
T
-
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
---
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
--
G
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
-------------
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
29
PsiBlast_CBE
74.40
33%
-102
- C1 -
4U02
1
?
C:
[2-241]
---
E
P
I
I
R
I
R
N
L
H
----
K
W
F
---
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
---
N
R
L
E
D
F
Q
-
E
G
E
V
V
V
D
G
---
L
S
V
K
D
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
-
R
W
P
R
E
K
A
E
K
K
A
L
-
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
----------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
74.32
32%
-98
- C1 -
2OLK
2
?
B:
[25-262]
-------------
I
D
V
H
Q
L
K
KSF
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
---
N
L
L
E
D
F
D
-
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
74.29
33%
-100
- C1 -
4YMW
-
?
J:
[1-239]
-----
M
I
F
V
N
D
V
Y
K
N
F
-------
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
---
N
L
L
E
E
P
T
-
K
G
E
V
F
I
D
G
V
K
-
I
N
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
---
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-----------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
74.20
33%
-95
- C1 -
4YMU
2
?
A:
[1-239]
-----
M
I
F
V
N
D
V
Y
K
N
F
-------
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
---
N
L
L
E
E
P
T
-
K
G
E
V
F
I
D
G
V
K
-
I
N
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
---
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-----------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
74.06
32%
-99
- C1 -
2OLK
1
?
C:
[25-262]
-------------
I
D
V
H
Q
L
K
KSF
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
---
N
L
L
E
D
F
D
-
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
73.91
32%
-99
- C1 -
2OLK
1
?
D:
[25-262]
-------------
I
D
V
H
Q
L
K
KSF
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
---
N
L
L
E
D
F
D
-
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.79
33%
-97
- C1 -
4YMU
2
?
J:
[1-239]
-----
M
I
F
V
N
D
V
Y
K
N
F
-------
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
---
N
L
L
E
E
P
T
-
K
G
E
V
F
I
D
G
V
K
-
I
N
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
---
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-----------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
73.71
33%
-95
- C1 -
4YMV
1
?
A:
[1-239]
-----
M
I
F
V
N
D
V
Y
K
N
F
-------
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
---
N
L
L
E
E
P
T
-
K
G
E
V
F
I
D
G
V
K
-
I
N
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
---
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-----------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.68
33%
-100
- C1 -
3TUI
1
METN_ECOLI
C:
[24-266]
-----
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
---
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
---
N
L
L
E
R
P
T
-
E
G
S
V
L
V
D
G
Q
E
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
--
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
---
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
--
G
D
K
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
-------------
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
10
PsiBlast_PDB
73.65
33%
-97
- C1 -
4YMS
-
?
J:
[1-239]
-----
M
I
F
V
N
D
V
Y
K
N
F
-------
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
---
N
L
L
E
E
P
T
-
K
G
E
V
F
I
D
G
V
K
-
I
N
N
G
K
V
N
I
N
K
V
R
-
Q
K
V
G
M
V
F
Q
H
--
F
N
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P
V
K
V
K
-
K
M
N
K
K
E
A
E
E
L
A
V
-
D
L
L
A
K
V
G
L
L
D
K
K
D
Q
---
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
L
-----------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
73.54
33%
-94
- C1 -
4U02
1
?
B:
[2-241]
---
E
P
I
I
R
I
R
N
L
H
----
K
W
F
---
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
---
N
R
L
E
D
F
Q
-
E
G
E
V
V
V
D
G
---
L
S
V
K
D
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
--
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
-
R
W
P
R
E
K
A
E
K
K
A
L
-
E
L
L
E
R
V
G
I
L
D
---
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
L
H
----------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.14
32%
-98
- C1 -
2OLK
1
?
A:
[25-262]
-------------
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
---
N
L
L
E
D
F
D
-
E
G
E
I
I
I
D
G
I
N
L
-
K
A
K
D
T
N
L
N
K
V
R
-
E
E
V
G
M
V
F
Q
R
--
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
M
K
V
R
-
K
W
P
R
E
K
A
E
A
K
A
M
-
E
L
L
D
K
V
G
L
---
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
F
-----------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
55.04
31%
-92
- C1 -
2PMK
1
A:
[23-236]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
54.37
31%
-89
- C1 -
2FF7
1
A:
[27-240]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
53.93
31%
-90
- C1 -
2FFA
2
A:
[27-240]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
53.32
31%
-90
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[21-234]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
52.17
31%
-84
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[27-240]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
52.14
31%
-90
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[27-240]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
51.85
31%
-87
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[27-240]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
51.77
31%
-88
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[27-240]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
51.56
31%
-85
- C1 -
1XEF
3
D:
[21-234]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
51.27
31%
-83
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[21-234]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
50.56
31%
-84
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[27-240]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
50.53
31%
-86
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[21-234]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
50.35
31%
-85
- C1 -
2FGK
2
D:
[27-240]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
49.64
31%
-81
- C1 -
2FGJ
2
D:
[27-240]
------------------------------
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
----
G
Q
V
L
I
D
G
H
D
L
A
-
L
A
D
P
N
W
L
R
---
R
Q
V
G
V
V
L
Q
D
N
V
L
-
L
N
R
S
I
I
D
N
I
S
L
A
N
P
G
M
S
V
E
-
K
V
I
Y
A
A
K
L
A
G
A
H
-
D
F
I
S
E
L
R
-
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
K
G
R
--
T
V
I
I
I
A
A
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
-----------------------------------------------------------------------------------------------------