@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0156: (2015-11-28 )
MAGHEVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFQDFLDAGLKEVFEDVLPISNFTDTMDLEFVGYELKEPKYTLEEARIHDASYSAPIFVTFRLVNKETGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVIPNRGAWLELETDAKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIVDIFGDSELVRNTIEKDIHKNPSDSRTDEALKEIYERLRPGEPKTADSSRSLLVARFFDPRRYDLAAVGRYKINKKLNLKTRLLNQTIAENLVDGETGEILVEAGTVMTRDVIDSIAEHIDGDLNKFVYTPNDYAVVTEPVILQKFKVVAPTDPDRVVTIVGNSNPEDKVRALTPADILAEMSYFLNLAEGIGKVDDIDHLGNRRIRAVGELLANQFRIGLARMERNVRERMSVQDNEVLTPQQIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINNLSSFGHLNKYGFIQTPYRKVDRSTGAVTNEIVWLTADEEDEFTVAQANSKLNEDGTFAEEIVMGRHQGNNQEFPSSIVDFVDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLIDPKAPYVGTGMEYQAAHDSGAAVIAKHDGRVIFSDAEKVEVRREDGSLDVYHVQKFRRSNSGTAYNQRTLVKVGDLVEKGDFIADGPSMENGEMALGQNPVVAYMTWEGYNFEDAVIMSERLVKEDVYTSVHLEEFESETRDTKLGPEEITREIPNVGEDSLRDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDTSLRVPHGGDGVVRDVKIFTRANGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARNLGIHIATPVFDGASSEDLWETVQEAGMDSDAKTVLYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARSVGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVLQEILTYKSDDVTGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDNEVELRDLDEGEDDDVMHVDDLEKARVKQEAEEKQAEQVSEVVQED
Atome Classification :
(32 SA)
.........10........20........30........40----------..----------......50......---..---60........70........80........90........-------100.......110.......120.......130.......140......---.150.......160..--.....170.......180.......190.......200.......210....-...220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340-.....---------....350.......360--........370----------------------........380.......390.......--400.........410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700------........710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880........890.-.----------------------------------------------------------------------------------------------------......900.......910.......920.......930.......940.......950.......960.......970.......980----------------------------------------------------.........990...-----------------------------....1000------------------------------------------.-------------...--------------.------------------------------.------------------------------.1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAGHEVQYG
K
H
R
T
R
R
S
F
S
R
I
K
E
V
LDLP
N
L
I
E
IQT
D
S
F
Q
D
F
L
----------
D
A
----------
G
L
K
E
V
F
E
D
VLPISN---FT---D
T
M
D
L
E
F
VGYELKEPKY
T
L
E
E
A
R
IHDASYS
A
P
I
F
V
T
F
R
L
V-------NKETGE
I
K
T
Q
E
V
F
FGDF
P
I
M
T
EM
G
T
F
I
INGG
E
R
I
I
V
S
Q
L
V
RSPG
V
Y
FND---KVDKNGKVGYGSTVIP--NRG
A
W
L
E
L
ETDAKD
I
A
Y
T
RIDRTRKI
P
F
T
T
L
V
R
A
LGFSGDD
E
I
V
D
IFG
D
S
E
L
-
V
R
N
T
I
E
K
D
IHKNPSDS
R
T
D
E
A
L
K
E
I
Y
E
R
LRPGEPKTADSSR
S
L
L
V
A
RFFDPRRY
D
L
A
A
V
G
R
Y
K
INKKL
N
L
K
T
R
L
L
N
Q
T
I
A
E
N
LVDGET
G
E
I
L
V
EAGTV
M
T
R
D
V
I
D
S
I
A
E
H
IDG
D
L
N
K
F
V
YTPND---
Y
A
V
VT---------E
P
V
I
L
Q
K
F
K
VVAPTDP---D
R
V
V
T
I
VGNS-----------------------NP
E
D
K
V
R
AL
T
P
A
D
I
L
A
E
M
S
Y
F
L
N
L
A
E
G
I--G--KVD
D
I
D
H
LGN
R
R
I
R
A
V
G
E
L
L
A
N
Q
F
R
I
G
L
A
R
M
E
R
N
V
R
E
R
MSVQDNEVL
T
P
Q
Q
I
I
NIR
P
V
T
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
D
QHN
P
L
S
E
L
S
H
K
R
R
LSALGPGGLTRDRAG
Y
E
V
R
D
V
H
Y
THYGRMCPIETPEGPNIGLINN
L
S
SFGHLNKYGFIQ
T
P
Y
R
K
VDRSTGAVT
N
E
I
V
W
L
TADEED
E
F
T
V
AQANSKLNEDG
T
F
A
E
E
I
V
M
GRHQGNNQEF
P
S
S
I
V
D
F
VDV
S
P
K
Q
V
V
A
V
A
T
A
C
I
P
FLENDDSN
R
A
L
MGANMQRQAVPLIDPKAPYVGTGM
E
Y
QAAHDS
G
A
A
V
I
A
KHD
G
R
V
I
FSDA
E
K
V
E
V
RREDG-------SL
D
V
Y
H
V
Q
K
F
R
RSNSGTAYN
Q
R
T
L
V
K
V
G
D
L
VEKGDFIADGPSMENG
E
M
ALGQN
P
V
V
A
Y
M
T
WEGYNF
E
D
A
V
I
M
S
E
R
L
V
K
E
DV
Y
T
S
V
H
L
E
E
F
ESETRDTKL
G
P
E
E
I
T
R
EIPNV
G
E
D
S
L
R
D
L
D
EM
G
I
I
R
IGAEVKEG
D
I
L
V
G
KVTPKGEKDL
S
A
E
E
R
L
L
H
A
I
FGDKSREVRDTSLRVPHGGDG-
V
V
R
D
V
K
I
F
T
R-A-
N
----------------------------------------------------------------------------------------------------
G
D
E
L
Q
S
G
V
N
M
L
V
R
V
YIAQK
R
K
I
KVGD
K
M
AGRHGNK
G
V
V
S
RIVPVEDMPYLPDG
T
P
V
D
I
M
LNPLGVPSRM
N
I
G
Q
V
M
E
L
H
L
G
M
A
ARNL
G
------------------------------------------------------
I
H
I
ATPVFDGA
S
S
E
D
-----------------------------
L
W
E
T
V
Q
E
-------------------------------------------A-------------GMD--------------S------------------------------D------------------------------A
K
T
V
L
YDGRTGEPFDNR
V
S
V
G
V
M
Y
M
I
K
L
H
H
MVDDKLHARSVGPY
S
L
V
TQQPLGGKAQFGGQRFGE
M
E
V
W
A
L
EAY
G
A
S
N
V
L
Q
E
I
L
T
YKSDDVT
G
R
L
K
A
Y
E
A
I
TKGKPIPKPGV
P
E
S
F
R
V
L
V
K
E
L
Q
SLGL
D
M
R
VLDEDDNE
V
E
L
RDLDEGEDDD
V
M
H
V
D
D
L
E
K
A
R
V
K
Q
E
A
E
E
K
Q
A
E
Q
V
S
E
V
V
QED
114
HHSearch
76.87
53%
-55
- C7 -
2A6H
1
RPOB_THET8
C:
[2-1112]
------------
E
I
K
R
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
R
R
A
L
----------
Q
A
DVPPEKRENV
G
I
Q
A
A
F
R
E
T
F
P
I
E
E
---
E
D
KGK
G
G
L
V
L
D
F
L
E
Y
R
L
G
E
P
P
F
P
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
L
I
K
E
D
E
V
F
L
G
H
I
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
T
P
---
D
P
A
R
--
P
G
R
Y
I
A
S
I
I
P
LP
K
R
G
P
W
I
D
L
E
V
E
P
N
G
V
V
S
M
K
V
N
K
-
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
-
L
A
R
E
L
G
A
Y
G
E
L
V
Q
G
L
M
D
E
S
V
----
F
A
M
R
P
E
E
A
L
I
R
L
F
T
L
L
R
P
G
D
P
P
K
R
D
K
A
V
A
Y
V
Y
G
L
I
A
D
P
R
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
I
R
------------
L
S
---------------
G
R
T
L
A
R
F
E
D
G
---------------------------------------------------------------------------------------
E
F
---
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
PG
H
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
V
G
--
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
N
-
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
-
I
V
V
R
T
V
R
L
R
R
-
G
D
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
IKELLAQAFEVYFGKRKGEGFGVDKREVE
V
L
R
R
A
E
K
-------------------------------------------
L
-------------
G
L
V
TPGKTPEEQLKELF
L
------------------------------
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
R
---------------------------------
105
Fugue
76.84
51%
-55
- C7 -
3LU0
-
RPOB_ECOLI
C:
[8-1342]
---------
K
K
R
I
R
K
D
F
G
K
R
P
Q
V
L
D
V
P
Y
L
L
S
I
Q
L
D
S
F
Q
K
F
I
----------
E
Q
DPEGQY----
G
L
E
A
A
F
R
S
V
F
P
I
Q
S
---
Y
S
---
G
N
S
E
L
Q
Y
V
S
Y
R
L
G
E
P
V
F
D
V
Q
E
C
Q
I
R
G
V
T
Y
S
A
P
L
R
V
K
L
R
L
V
IYEREAP
E
G
T
V
K
D
I
K
E
Q
E
V
Y
M
G
E
I
P
L
M
T
D
N
G
T
F
V
I
N
G
T
E
R
V
I
V
S
Q
L
H
R
S
P
G
V
F
F
D
S
DKG
K
T
H
S
S
G
K
V
L
Y
N
A
R
I
I
P
--
Y
R
G
S
W
L
D
F
E
F
D
P
K
D
N
L
F
V
R
I
D
R
R
R
K
L
P
A
T
I
I
L
R
A
L
N
Y
T
T
E
Q
I
L
D
L
F
F
E
K
V
I
F
-
E
I
R
D
N
K
L
Q
M
E
L
V
P
E
R
L
R
G
E
T
A
S
F
D
I
E
A
----
N
G
K
V
Y
V
E
K
G
R
R
I
--------
T
A
R
H
I
R
Q
L
E
K
D
D
V
K
L
I
E
V
P
V
E
Y
I
A
G
K
V
V
A
K
D
Y
I
D
E
S
T
G
E
L
I
C
A
A
N
M
E
L
S
L
D
L
L
A
K
L
S
Q
S
G
H
K
R
I
E
T
L
F
T
N
D
L
D
HGP
Y
I
S
E
T
LRVDPTNDR
L
S
A
L
V
E
I
Y
R
M
M
R
P
G
E
P
PTR
E
A
A
E
S
L
F
E
N
L
FFSEDRYDLSAVGRMKFNRSLLR
E
E
I
E
G
S
G
I
L
S
K
D
D
I
I
D
V
M
K
K
L
I
D
I
R
N
G
K
--
G
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
S
V
G
E
M
A
E
N
Q
F
R
V
G
L
V
R
V
E
R
A
V
K
E
R
L
S
L
G
D
L
D
T
L
M
P
Q
D
M
I
N
A
K
P
I
S
A
A
V
K
E
F
F
G
S
S
Q
L
S
Q
F
M
V
Q
N
N
P
L
S
E
I
T
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
E
V
R
D
V
H
P
T
H
Y
G
R
V
C
P
I
E
T
P
E
G
P
N
I
G
L
I
N
S
L
S
V
Y
A
Q
T
N
E
Y
G
F
L
E
T
P
Y
R
K
V
T
D
--
G
V
V
T
D
E
I
H
Y
L
S
A
I
E
E
G
N
Y
V
I
A
Q
A
N
S
N
L
D
E
E
G
H
F
V
E
D
L
V
T
C
R
S
K
G
E
S
S
L
F
S
R
D
Q
V
D
Y
M
D
V
S
T
Q
Q
V
V
S
V
G
A
S
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
A
N
M
Q
R
Q
A
V
P
T
L
R
A
D
K
P
L
V
G
T
G
M
E
R
A
V
A
V
D
S
G
V
T
A
V
A
K
R
G
G
V
V
Q
Y
V
D
A
S
R
I
V
I
K
V
N
E
D
EMYPGEA
G
I
D
I
Y
N
L
T
K
Y
T
R
S
N
Q
N
T
C
I
N
Q
M
P
C
V
S
L
G
E
P
V
E
R
G
D
V
L
A
D
G
P
S
T
D
L
G
E
L
A
L
G
Q
N
M
R
V
A
F
M
P
W
N
G
Y
N
F
E
D
S
I
L
V
S
E
R
V
V
Q
E
D
R
F
T
T
I
H
I
Q
E
L
A
C
V
S
R
D
T
K
L
G
P
E
E
I
T
A
D
I
P
N
V
G
E
A
A
L
S
K
L
D
E
S
G
I
V
Y
I
G
A
E
V
T
G
G
D
I
L
V
G
K
V
T
P
K
G
E
T
Q
L
T
P
E
E
K
L
L
R
A
I
F
G
E
K
A
S
D
V
K
D
S
S
L
R
V
P
N
G
V
S
G
-
T
V
I
D
V
Q
V
F
T
R
-
D
-
G
VEKDKRALEIEEMQLKQAKKDLSEELQILEAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQLEQLAEQYDELKHEFEKKLEAKRRKITQ
G
D
D
L
A
P
G
V
L
K
I
V
K
V
Y
L
A
V
K
R
R
I
Q
P
G
D
K
M
A
G
R
H
G
N
K
G
V
I
S
K
I
N
P
I
E
D
M
P
Y
D
E
N
G
T
P
V
D
I
V
L
N
P
L
G
V
P
S
R
M
N
I
G
Q
I
L
E
T
H
L
G
M
A
A
K
G
I
G
DKINAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDEEVMRLAENLRKG
M
P
I
A
T
P
V
F
D
G
A
K
E
A
E
-----------------------------
I
K
E
L
L
K
L
-------------------------------------------
G
-------------
D
L
P
--------------
T
------------------------------
S
------------------------------
G
Q
I
R
L
Y
D
G
R
T
G
E
Q
F
E
R
P
V
T
V
G
Y
M
Y
M
L
K
L
N
H
L
V
D
D
K
M
H
A
R
S
T
G
S
Y
S
L
V
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
Y
T
L
Q
E
M
L
T
V
K
S
D
D
V
N
G
R
T
K
M
Y
K
N
I
V
D
G
N
H
Q
M
E
P
G
M
P
E
S
F
N
V
L
L
K
E
I
R
S
L
G
I
N
I
E
L
E
D
E
------------------------------------------------
34
PsiBlast_CBE
75.46
57%
-56
- C7 -
4G7H
2
RPOB_THET8
M:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
104
Fugue
75.39
52%
-42
- C7 -
1HQM
-
RPOB_THEAQ
C:
[2-1115]
------------
K
I
K
R
F
G
R
I
R
E
V
I
P
L
P
P
L
T
E
I
Q
V
E
S
Y
K
K
A
L
QADVPPEKRE
N
V
----------
G
I
Q
A
A
F
K
E
T
F
P
I
E
E
GDK
G
K
---
G
G
L
V
L
D
F
L
E
Y
R
I
G
D
P
P
F
S
Q
D
E
C
R
E
K
D
L
T
Y
Q
A
P
L
Y
A
R
L
Q
L
I
-------
H
K
D
T
G
L
I
K
E
D
E
V
F
L
G
H
L
P
L
M
T
E
D
G
S
F
I
I
N
G
A
D
R
V
I
V
S
Q
I
H
R
S
P
G
V
Y
F
T
P
---
D
P
A
R
P
G
R
Y
I
A
S
I
I
P
L
P
--
K
R
G
P
W
I
D
L
E
V
E
A
S
G
V
V
T
M
K
V
N
K
-
R
K
F
P
L
V
L
L
L
R
V
L
G
Y
D
Q
E
T
L
V
R
E
L
S
A
Y
G
D
L
-
V
Q
G
L
L
D
E
A
V
L
A
M
----
R
P
E
E
A
M
V
R
L
F
T
L
L
R
P
G
D
P
P
K
K
D
K
A
L
A
Y
L
F
G
L
L
A
D
P
K
R
Y
D
L
G
E
A
G
R
Y
K
A
E
E
K
L
G
V
G
L
S
----------------------------------------------------------------------------------------------
G
R
T
-----------------------
L
V
R
F
E
D
G
E
F
K
D
E
V
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
PG
H
--
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
A
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
V
M
G
S
P
D
T
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
L
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
A
L
G
F
I
R
T
P
Y
R
R
V
K
N
--
G
V
V
T
E
E
V
V
Y
M
T
A
S
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
D
R
I
A
T
D
R
-
V
V
A
R
R
R
G
E
P
V
I
V
A
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
L
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
V
K
V
D
G
T
R
I
A
V
R
-
Y
E
D
-------
G
R
L
V
H
P
L
R
R
Y
A
R
S
N
Q
G
T
A
F
D
Q
R
P
R
V
R
V
G
Q
R
V
K
K
G
D
L
L
A
D
G
P
A
S
E
E
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
I
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
Q
E
P
S
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
-
I
V
V
G
R
L
R
L
R
R
G
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
F
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
V
F
D
G
A
T
E
P
E
-----------------------------
I
K
E
L
L
A
E
AFNLY
F
G
K
R
Q
G
EGFGVD
K
R
E
K
E
V
L
ARAEKLGLVSPGKS
P
E
E
Q
L
K
-------------
E
L
F
--------------
D
------------------------------
L
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
F
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
I
K
S
D
D
I
E
G
R
N
A
A
Y
Q
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
-------------------------------------
17
PsiBlast_PDB
75.32
57%
-56
- C7 -
4G7H
2
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
F
E
V
Y
F
G
K
R
K
G
E
GF
G
V
D
--------------
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
30
PsiBlast_CBE
75.19
57%
-53
- C7 -
4MQ9
2
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
F
E
V
Y
F
GKRKGEGF
G
V
D
--------------
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
R
---------------------------------
26
PsiBlast_CBE
75.07
57%
-57
- C7 -
4OIQ
3
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
F
E
V
Y
F
G
K
R
K
G
E
GF
G
V
D
--------------
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
29
PsiBlast_CBE
74.96
57%
-58
- C7 -
4OIN
4
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
F
E
V
Y
F
G
K
R
K
G
E
GF
G
V
D
--------------
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
27
PsiBlast_CBE
74.94
57%
-55
- C7 -
4OIP
5
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
F
E
V
Y
F
G
K
R
K
G
E
GF
G
V
D
--------------
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
25
PsiBlast_CBE
74.78
57%
-55
- C7 -
4OIR
4
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
F
E
V
Y
F
G
K
R
K
G
E
GF
G
V
D
--------------
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
24
PsiBlast_CBE
74.72
57%
-57
- C7 -
4Q4Z
4
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
F
E
V
Y
F
G
K
R
K
G
E
GF
G
V
D
--------------
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
33
PsiBlast_CBE
74.62
57%
-53
- C7 -
4G7O
3
RPOB_THET8
M:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
28
PsiBlast_CBE
74.61
57%
-54
- C7 -
4OIO
5
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
F
E
V
Y
F
G
K
R
K
G
E
GF
G
V
D
--------------
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
18
PsiBlast_PDB
74.53
57%
-54
- C7 -
4G7O
3
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
F
E
V
Y
F
G
K
R
K
G
E
GF
G
V
D
--------------
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
23
PsiBlast_CBE
74.22
57%
-54
- C7 -
4Q5S
4
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
F
E
V
Y
F
G
K
R
K
G
E
GF
G
V
D
--------------
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
19
PsiBlast_PDB
74.17
57%
-52
- C7 -
4G7Z
2
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
G
H
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
F
E
V
Y
F
G
K
R
K
G
E
GF
G
V
D
--------------
K
R
E
V
E
V
L
R
R
A
E
K
L
GLVTPGKT
P
E
E
Q
L
K
E
L
F
L
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
49
PsiBlast_CBE
73.98
56%
-54
- C7 -
1YNN
1
RPOB_THEAQ
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
A
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
V
M
G
S
P
D
T
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
L
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
A
L
G
F
I
R
T
P
Y
R
R
V
--
K
N
G
V
V
T
E
E
V
V
Y
M
T
A
S
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
D
-
R
I
A
T
D
R
V
V
A
R
R
R
G
E
P
V
I
V
A
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
L
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
V
K
V
D
G
T
R
I
A
V
R
Y
E
D
G
-------
R
L
V
E
H
P
L
R
R
Y
A
R
S
N
Q
G
T
A
F
D
Q
R
P
R
V
R
V
G
Q
R
V
K
K
G
D
L
L
A
D
G
P
A
S
E
E
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
I
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
Q
E
P
S
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
-
I
V
V
G
R
L
R
L
R
R
-
G
-
D
P---------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
F
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
V
F
D
G
A
T
E
P
E
-----------------------------
I
K
E
L
L
A
E
-------------------------------------------
A
F
N
L
Y
F
G
K
R
Q
G
E
GF
G
V
D
--------------
K
------------------------------
R
E
K
E
V
L
A
R
A
E
K
L
GLVSPGKS
P
E
E
Q
L
K
E
L
F
D
L
G
K
V
V
L
Y
D
G
R
T
G
E
P
F
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
I
K
S
D
D
I
E
G
R
N
A
A
Y
Q
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
--------------------------------------
32
PsiBlast_CBE
73.86
57%
-54
- C7 -
4G7Z
2
RPOB_THET8
M:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
----------------------------------
20
PsiBlast_PDB
73.74
57%
-54
- C7 -
4GZY
2
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
-----------------------
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
----------------------------------------
50
PsiBlast_CBE
73.69
56%
-56
- C7 -
1YNJ
1
RPOB_THEAQ
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
A
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
V
M
G
S
P
D
T
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
L
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
A
L
G
F
I
R
T
P
Y
R
R
V
--
K
N
G
V
V
T
E
E
V
V
Y
M
T
A
S
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
E
G
D
-
R
I
A
T
D
R
V
V
A
R
R
R
G
E
P
V
I
V
A
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
L
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
V
K
V
D
G
T
R
I
A
V
R
Y
E
D
G
-------
R
L
V
E
H
P
L
R
R
Y
A
R
S
N
Q
G
T
A
F
D
Q
R
P
R
V
R
V
G
Q
R
V
K
K
G
D
L
L
A
D
G
P
A
S
E
E
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
I
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
Q
E
P
S
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
-
I
V
V
G
R
L
R
L
R
R
-
G
-
D
P---------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
F
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
V
F
D
G
A
T
E
P
E
-----------------------------
I
K
E
L
L
A
E
-------------------------------------------
A
F
N
L
Y
F
G
K
R
Q
G
E
GF
G
V
D
--------------
K
------------------------------
R
E
K
E
V
L
A
R
A
E
K
LGLVSPGKS
P
E
E
Q
L
K
E
L
F
D
L
G
K
V
V
L
Y
D
G
R
T
G
E
P
F
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
I
K
S
D
D
I
E
G
R
N
A
A
Y
Q
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
--------------------------------------
37
PsiBlast_CBE
73.54
57%
-54
- C7 -
3AOI
2
RPOB_THET8
M:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
----------------------
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
----------------------------------------
38
PsiBlast_CBE
73.21
57%
-55
- C7 -
3AOI
2
RPOB_THET8
H:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
--------------------------
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
----------------------------------------
16
PsiBlast_PDB
72.86
57%
-54
- C7 -
3AOI
2
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
-----------------------
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
----------------------------------------
10
PsiBlast_PDB
72.40
57%
-51
- C7 -
2O5I
3
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
R
---------------------------------
41
PsiBlast_CBE
72.35
57%
-51
- C7 -
2O5I
3
RPOB_THET8
M:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
R
---------------------------------
39
PsiBlast_CBE
72.32
57%
-49
- C7 -
2PPB
6
RPOB_THET8
M:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
R
---------------------------------
40
PsiBlast_CBE
72.24
57%
-51
- C7 -
2O5J
5
RPOB_THET8
M:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
R
---------------------------------
15
PsiBlast_PDB
72.20
57%
-54
- C7 -
3AOH
2
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
----------------------------------------
12
PsiBlast_PDB
72.02
57%
-50
- C7 -
2PPB
4
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
R
---------------------------------
11
PsiBlast_PDB
71.76
57%
-52
- C7 -
2O5J
4
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
R
---------------------------------
22
PsiBlast_CBE
71.69
57%
-52
- C7 -
4WQS
2
RPOB_THET8
C:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
R
---------------------------------
21
PsiBlast_CBE
71.34
57%
-52
- C7 -
4WQS
2
RPOB_THET8
M:
[303-1111]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
L
P
T
L
R
Y
L
F
A
L
T
A
G
V
--
P
GH
E
V
D
D
I
D
H
L
G
N
R
R
I
R
T
V
G
E
L
M
T
D
Q
F
R
V
G
L
A
R
L
A
R
G
V
R
E
R
M
L
M
G
S
E
D
S
L
T
P
A
K
L
V
N
S
R
P
L
E
A
A
I
R
E
F
F
S
R
S
Q
L
S
Q
F
K
D
E
T
N
P
L
S
S
L
R
H
K
R
R
I
S
A
L
G
P
G
G
L
T
R
E
R
A
G
F
D
V
R
D
V
H
R
T
H
Y
G
R
I
C
P
V
E
T
P
E
G
A
N
I
G
L
I
T
S
L
A
A
Y
A
R
V
D
E
L
G
F
I
R
T
P
Y
R
R
V
--
V
G
G
V
V
T
D
E
V
V
Y
M
T
A
T
E
E
D
R
Y
T
I
A
Q
A
N
T
P
L
-
E
G
N
R
I
A
A
E
R
V
V
A
R
R
K
G
E
P
V
I
V
S
P
E
E
V
E
F
M
D
V
S
P
K
Q
V
F
S
V
N
T
N
L
I
P
F
L
E
H
D
D
A
N
R
A
L
M
G
S
N
M
Q
T
Q
A
V
P
L
I
R
A
Q
A
P
V
V
M
T
G
L
E
E
R
V
V
R
D
S
L
A
A
L
Y
A
E
E
D
G
E
V
A
K
V
D
G
N
R
I
V
V
R
Y
E
D
G
-------
R
L
V
E
Y
P
L
R
R
F
Y
R
S
N
Q
G
T
A
L
D
Q
R
P
R
V
V
V
G
Q
R
V
R
K
G
D
L
L
A
D
G
P
A
S
E
N
G
F
L
A
L
G
Q
N
V
L
V
A
I
M
P
F
D
G
Y
N
F
E
D
A
I
V
I
S
E
E
L
L
K
R
D
F
Y
T
S
I
H
I
E
R
Y
E
I
E
A
R
D
T
K
L
G
P
E
R
I
T
R
D
I
P
H
L
S
E
A
A
L
R
D
L
D
E
E
G
V
V
R
I
G
A
E
V
K
P
G
D
I
L
V
G
R
T
S
F
K
G
E
S
E
P
T
P
E
E
R
L
L
R
S
I
F
G
E
K
A
R
D
V
K
D
T
S
L
R
V
P
P
G
E
G
G
I
V
V
R
T
V
R
L
R
R
G
-
D
-
P
----------------------------------------------------------------------------------------------------
G
V
E
L
K
P
G
V
R
E
V
V
R
V
Y
V
A
Q
K
R
K
L
Q
V
G
D
K
L
A
N
R
H
G
N
K
G
V
V
A
K
I
L
P
V
E
D
M
P
H
L
P
D
G
T
P
V
D
V
I
L
N
P
L
G
V
P
S
R
M
N
L
G
Q
I
L
E
T
H
L
G
L
A
G
Y
F
L
G
------------------------------------------------------
Q
R
Y
I
S
P
I
F
D
G
A
K
E
P
E
-----------------------------
I
K
E
L
L
A
Q
-------------------------------------------
A
FEVYFGKRKGEGF
G
V
D
--------------
K
REVEVLRRAEKLGLVTPGKTPEEQLKELFL
Q
------------------------------
G
K
V
V
L
Y
D
G
R
T
G
E
P
I
E
G
P
I
V
V
G
Q
M
F
I
M
K
L
Y
H
M
V
E
D
K
M
H
A
R
S
T
G
P
Y
S
L
I
T
Q
Q
P
L
G
G
K
A
Q
F
G
G
Q
R
F
G
E
M
E
V
W
A
L
E
A
Y
G
A
A
H
T
L
Q
E
M
L
T
L
K
S
D
D
I
E
G
R
N
A
A
Y
E
A
I
I
K
G
E
D
V
P
E
P
S
V
P
E
S
F
R
V
L
V
K
E
L
Q
A
L
A
L
D
V
Q
T
L
D
E
K
D
N
P
V
D
I
F
E
G
L
A
S
K
R
---------------------------------