@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0180: (2015-11-29 )
MLMVLLFQRLGIIMILAFLLVNNSYFRQLIEERSKRETVVLVIIFGLFVIISNITGIEIKGDRSLVERPFLTTISHSDSLANTRTLVITTASLVGGPLVGSIVGFIGGVHRFFQGSFSGSFYIVSSVLVGIVSGKIGDKLKENHLYPSTSQVILISIIAESIQMLFVGIFTGWELVKMIVIPMMILNSLGSTLFLAILKTYLSNESQLRAVQTRDVLELTRQTLPYLRQGLTPQSARSVCEIIKRHTNFDAVGLTDRSNVLAHIGVGHDHHIAGQPVKTDLSKSVIFDGEPRIAQDKAAISCPDHNCQLNSAIVVPLKINDKTVGALKMYFAGDKTMSEVEENLVLGLAQIFSGQLAMGITEEQNKLASMAEIKALQAQINPHFFFNAINTISALIRIDSDKARYALMQLSTFFRTSLQGGQDREVTLEQEKSHVDAYMNVEKLRFPDKYQLSYDISAPEKMKLPPFGLQVLVENAVRHAFKERKTDNHILVQIKPDGHYYCVSVSDNGQGISDTIIDKLGQETVAESKGTGTALVNLNNRLNLLYGSVSCLHFSSDKNGTKVWYRIPNRIREDEHENFNS
Atome Classification :
(20 SA)
-------------.........---10.--------.......20........30........40........50........60........70........--80........90........100...-..--..110--------........--------120.......130.......140-......--..-----------.150..------.....160.......170--.......180..--.----....190.----......200........210.......220-........230......-.240.......----------------250.......260.......270.......280.--......290.......300........310........320.......330--.........340.--------......350----.......360....-----...370.......380.......390......-------------------------.-----------------------------400-----........410.......420----...-------.....430.......440....---------------------.------..450.---.....---.---460--.---........470----........480..--------...-------.-------.490...------.--...-500.......510....------------------------...520...---..-------.-------------.-530.......540---------------..-......550..---------...-..560..-..-----...570.....------..580--------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------
M
L
M
V
L
L
F
Q
R
---
L
G
I
--------
I
M
I
L
A
F
L
LVN
N
S
Y
F
R
Q
L
I
E
E
RSKR
E
T
V
V
L
V
I
I
F
G
L
F
V
I
I
SNI
T
G
I
E
IKGD
R
S
L
V
ERP
F
L
T
TISHSDS--LAN
T
R
T
L
V
I
T
T
A
S
LVG
G
P
L
V
G
S
I
V
G
F
-
I
G
--
G
V
H
R
---------
F
F
QGSFSG--------
S
F
Y
I
V
S
S
V
L
V
G
I
V
SGKIG
D
K
L
---KENHLY--PS-----------TS
Q
V
I
L
------
I
S
I
I
A
E
S
I
Q
M
L
F
V
G
I
F
T
G
--
W
E
L
V
K
M
I
V
I
P
M
M
--
I
----
L
N
SL
G
S
T
L
----
F
L
A
I
L
K
T
Y
-LSN
E
S
Q
L
R
A
V
Q
T
R
D
V
L
E
L
T
R
--
Q
T
L
P
Y
L
R
QGL
T
P
Q
S
A
R
S
-
V
C
E
I
I
K
RHTNF----------------DAVGLTDRS
N
V
L
A
H
IGVGHDHHIAGQ
P
V
K
TDLSK--
S
V
IFDGEPRIAQDK
A
A
I
S-CPDHNCQLN
S
-
A
I
V
V
P
L
K
INDKT
V
G
A
L
K
M
Y
----FAGD
K
T
M
S
E
V
E
E
N
--------
L
V
L
G
L
A
Q
IF----SG
Q
L
AMGI
T
E
E
Q
N
K
-----
L
A
S
M
A
E
I
K
A
L
Q
A
QIN
P
H
F
F
F
N
A
I
N
T
I
S
A
L
I
RI-------------------------D-----------------------------SD------
K
A
R
Y
A
L
M
Q
L
S
T
F
F
R
T
SLQGG-----QDR-------EV
T
L
E
Q
E
K
S
H
V
D
A
Y
M
N
V
E
KLRF---------------------P------D
K
Y
Q
L
S
---YDISA---P---E----K---MKLP
P
F
G
L
Q
V
-----
L
V
E
N
A
V
R
H
A
F
K
ER--------KTD-------
N
-------
H
I
L
V
Q
I
K------P--DG
H
-
Y
Y
C
V
SVSDNGQG
I
S
D
T
I
------------------------
I
D
KL
G
Q
E
T
V
---AE-------S-------------K-GT
G
T
A
L
V
NLNN
R
----------------
L
N
-
L
L
Y
G
S
V
S
C
L
H
F---------SSD-KNG
T
K
V
W
-
Y
R-----I
P
N
R
IR
E
D
E
HE------NFNS---------------------------------
12
Fugue
57.96
17%
-38
- C3 -
5C8T
5
?
B:
[2-526]
------------A
E
N
V
T
G
L
F
K
D
---
C
S
----------
K
I
I
T
G
L
H
P
T
Q
A
P
T
H
L
S
V
D
I
K
F
K
T
E
--------
G
L
C
V
D
I
P
G
I
P
-------
K
D
M
T
Y
R
R
L
I
S
M
M
G
F
K
M
N
Y
Q
V
N
G
Y
P
N
M
F
I
T
R
E
E
A
I
R
H
--
V
R
A
W
I
G
F
D
V
E
--
G
C
H
A
T
R
DAVGTNL
P
L
Q
L
G
F
S
T
--------
G
V
N
L
V
A
-
V
P
T
G
Y
V
D
T
E
N
N
T
E
F
---
T
R
V
N
A
K
--
P
P
-----------
P
G
-----------
D
Q
F
K
H
L
I
P
L
M
Y
K
G
L
--
P
--
W
N
V
V
R
I
K
I
V
Q
M
L
S
D
T
----
L
K
G
L
S
D
R
V
----
V
F
V
L
W
A
------------------
H
G
F
E
L
--
T
S
M
K
Y
F
V
K
---
I
G
P
E
R
T
-
C
C
L
C
D
K
R
A
T
C
F
----------------
S
T
---
S
S
D
T
Y
A
C
W
N
H
S
V
G
F
D
--
Y
V
Y
N
P
F
M
I
D
V
Q
Q
--
W
G
F
T
G
N
L
Q
S
N
H
D
Q
H
C
Q
V
H
-
G
N
A
H
V
A
S
C
D
A
-
I
M
T
R
C
L
A
V
H
E
C
F
V
K
R
V
D
W
S
----
V
E
Y
P
I
I
G
D
E
L
R
V
N
--------
S
A
C
R
K
V
Q
H
M
----
V
V
K
S
A
L
-
L
A
D
K
F
P
V
-----
L
H
D
I
G
N
P
K
A
I
K
C
V
P
Q
A
E
V
E
W
K
F
Y
D
A
Q
P
C
-----------------------------------------------------------
S
D
------
K
A
Y
----
K
I
E
E
L
F
Y
S
------------
Y
-------
A
T
H
H
D
K
F
T
D
G
V
C
L
F
W
N
C
N
V
D
R
Y
---------------------
P
A-----
N
A
I
V
C
R
---
F
D
T
R
V
---
L
---
S
----
N
---
L
N
L
P
G
C
D
G
G
S
-----
L
Y
V
N
--
K
H
A
F
H
T
P
--------
A
F
D
-------
K
-------
S
A
F
T
N
L
K
------
Q
--
L
P
F
F
Y
Y
S
D
S
P
C
E
Y
V
P
L
K
S
A
T
C
------------------------
I
T
R
C
N
L
G
G
----
A
V
-------
C
-------------
R
-
H
H
A
N
E
Y
R
Q
Y
L
D
A
----------------
Y
N
-
M
M
I
S
A
---------------------
G
F
S
L
W
I
Y
K
-----
Q
F
D
T
--
Y
N
L
W
N
------
T
F
T
R
---------------------------------
13
Fugue
53.10
17%
-52
- C3 -
4J5T
4
CWH41_YEAST
A:
[1-811]
A
E
F
M
E
E
Y
Q
K
F
T
N
E
S
L
L
W
A
P
Y
R
S
NCY
F
G
M
R
P
R
YVHES
P
L
I
M
G
I
M
W
F
N
S
L
S
Q
D
G
L
H
S
L
R
H
F
A
T
P
Q
D
K
L
Q
K
Y
G
W
E
V
Y
D
P
R
I
G
G
K
E
V
F
I
D
E
K
N
-
N
L
N
L
T
V
Y
F
V
K
S
K
N
--
G
E
N
W
S
V
R
V
Q
G
E
P
L
D
P
K
R
P
S
T
A
S
V
V
L
Y
-
F
S
QN
G
G
E
I
---------
D
G
K
S
S
L
A
M
IGHDGPN
D
M
K
F
F
G
Y
S
K
E
L
G
E
Y
H
L
T
V
K
D
N
F
G
H
Y
F
K
N
P
E
Y
--
E
T
MEVAPGSDCS
K
T
S
H
L
S
L
Q
I
P
DKE
V
W
K
A
R
D
V
F
Q
S
L
V
S
D
S
I
R
D
--
I
L
E
R
P
A
D
L
I
P
S
V
--
L
TIRN
L
Y
N
F
N
P
G
N
----
F
H
Y
I
Q
K
T
F
D
L
T
K
K
D
G
F
Q
F
D
I
T
Y
N
K
L
G
-
T
T
--
Q
S
I
S
T
-
R
E
Q
V
T
E
L
I
T
W
S
-
L
N
E
I
N
A
R
F
D
K
Q
F
S
F
G
EGPDSIES
V
E
V
K
R
R
F
A
L
E
T
L
S
N
L
L
G
G
I
G
Y
F
Y
G
N
Q
L
I
D
R
E
T
E
F
D
E
S
Q
FT
E
I
K
L
L
N
A
K
E
E
G
P
F
E
L
F
T
S
-
V
P
S
R
G
F
F
P
R
G
F
Y
W
D
E
G
F
H
L
L
Q
I
M
E
Y
D
F
D
L
A
----
F
E
I
L
A
S
W
F
E
M
I
E
D
DSGWIAR
E
I
I
L
G
N
E
A
R
S
----
K
V
P
Q
E
F
Q
V
Q
N
P
N
I
A
NPP
T
L
L
L
A
F
S
E
M
L
S
R
A
I
E
N
I
G
D
F
M
T
N
N
L
E
A
N
P
G
L
L
T
E
-------------------------
Y
-----------------------------
A
K
------
K
I
Y
P
K
L
L
K
H
Y
N
W
F
R
K
S
Q
T
G
L
-----
I
D
E
-------
Y
E
E
I
L
E
D
E
G
I
W
D
K
I
H
K
N
E
V
Y
R
W
VGRTFTHCLPSGMDDYPRAQP
P
------
D
V
A
E
L
N
---
V
D
A
L
A
---
W
---
V
----
G
---
V
M
T
R
S
M
K
Q
I
A
-----
H
V
L
K
L
T
Q
D
E
Q
R
Y
A
--------
Q
I
E
-------
Q
-------
E
V
V
E
N
L
D
L
LHWSE
N
--
D
N
C
-
Y
C
D
I
S
I
D
P
E
D
D
E
I
R
E
F
V
CHEGYVSV
L
P
F
A
L
KLIPKNS
P
K
--
L
E
K
V
V
A
L
M
S
---
D
P
-------
E
-------------
K
I
F
S
D
Y
G
L
L
S
L
S
R
Q
DDYFGKDENYWR
G
P
I
W
M
N
-
I
N
Y
L
C
L
D
A
M
R
Y
Y
Y
PEVILDV
A
G
E
-
A
S
N
A
K
K
L
-
Y
Q
S
L
K
I
N
L
S
N
N
I
Y
K
V
W
E
E
QGYCYE
N
Y
S
P
IDGHGTGAEHFTGWTAL
V
V
N
I
L
G
R
F
RS
H
H
H
H
HH
17
HHSearch
50.12
17%
-29
- C3 -
3D36
4
?
A:
[17-226]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
A
S
I
-
S
H
E
I
R
N
P
L
T
A
A
R
G
F
I
Q
L
I
EEQPLA
A
D
K
R
R
Q
Y
A
R
I
A
I
E
-----
E
-----------------------------
L
D
------
R
A
E
A
I
I
T
D
Y
L
T
F
A
K
P
A
P
E
T
-------
P
E
-------
K
L
N
V
K
L
E
I
E
R
V
I
D
I
L
R
P
L
A
N
M
-----------------------------
S
C
V
D
I
Q
---
A
T
L
A
P
---
F
S
--
V
I
G
--
E
---
R
E
K
F
R
Q
C
L
L
N
-----
V
M
K
N
A
I
E
A
M
------------
P
N
G
-------
G
-------
T
L
Q
V
Y
V
S
------
I
--
D
N
G
-
R
V
L
I
R
I
A
D
T
G
V
G
M
T
K
E
Q
------------------------
L
E
R
L
G
E
P
Y
F
---
T
T
-------
K
GV-----------
K
-
G
T
G
L
G
M
M
V
V
Y
R
I
----------------
I
E
-
S
M
N
G
T
---
I
R
I
---------
E
S
E
I
H
K
G
T
T
V
S
-
I
Y
-----
L
P
L
A
S
-------------------------------------------------
29
HHSearch
49.92
19%
-34
- C3 -
1I58
3
CHEA_THEMA
A:
[4-188]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
---------------------
N
------
K
E
V
N
F
I
---
M
R
G
E
D
---
T
---
E
LD
R
T
F
---
V
E
E
I
G
E
P
L
L
H
-----
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
GK
P
P
I
-------
G
-------
T
L
I
L
S
A
R
------
H
--
E
G
N
-
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
K
GLID
E
S
K
A
A
T
LS
D
Q
E
I
L
N
F
L
F
V
P
G
F
---
S
T
-------
K
E
K
V
S
E
V
-------
S
-
G
R
G
V
G
M
D
V
V
K
N
V
----------------
V
E
-
S
L
N
G
S
---
I
S
I
---------
E
S
E
K
D
K
G
T
K
V
T
-
I
R
-----
L
P
L
T
--------------------------------------------------
14
Fugue
49.67
17%
-43
- C3 -
5DA0
2
?
A:
[14-484]
---------------------------------------------
Q
R
E
W
F
A
------
N
P
R
K
D
V
L
A
G
I
V
V
A
L
A
L
I
P
E
A
I
A
F
S
I
I
A
G
V
D
P
Q
V
G
L
Y
A
S
F
I
I
A
L
I
T
A
--
F
L
G
G
R
P
G
M
I
S
A
A
T
G
A
M
A
L
L
M
T
G
L
V
K
-----------------------
D
H
G
I
--------
Q
Y
L
F
A
A
T
V
L
T
G
V
L
Q
V
V
F
G
W
A
K
---
L
A
R
Y
L
K
FV
P
R
-----------
S
V
M
V
G
F
------
V
N
A
L
A
I
L
I
F
M
A
Q
L
P
Q
F
V
G
AN
W
Q
M
Y
A
M
V
A
A
G
L
A
--
I
----
I
Y
L
L
P
L
V
F
KAMP
S
A
L
V
A
I
V
V
-
L
T
V
V
A
V
V
T
G
A
D
V
K
T
V
G
D
M
G
T
LP
T
A
L
P
H
F
Q
F
P
Q
V
P
L
T
F
E
T
-
L
A
I
I
F
P
V
A
L
T
L
----------------
S
L
V
G
L
L
E
S
L
L
T
A
Q
L
I
D
E
R
T
D
---------
T
T
S
D
K
--
N
V
E
S
R
G
Q
G
V
A
N
I
V
T
G
F
F
G
-
G
M
A
G
C
A
M
I
G
Q
-
S
M
I
N
V
T
S
---
G
G
R
G
R
L
S
T
F
----
V
A
G
A
F
L
M
V
L
I
L
A
L
------------
Q
P
L
L
V
----
Q
I
P
M
A
A
L
V
A
V
M
M
V
V
-----
A
I
S
T
F
D
W
G
S
L
R
F
P
K
G
E
T
V
V
M
L
A
T
V
A
V
T
V
F
T
H
D
-------------------------
L
-----------------------------
S
L
------
G
V
L
I
G
V
V
L
S
A
L
F
F
A
R
K
V
S
-------
Q
L
S
-------
Q
V
T
P
V
D
E
V
D
G
T
R
T
Y
R
V
R
G
Q
L
F
F
---------------------
V
------
S
----------------------------------------------
T
H
D
F
L
H
Q
F
D
F
T
--------
H
P
A
-------
R
-------
R
V
V
I
D
L
S
---------
D
A
H
-
F
W
----
D
G
S
A
V
G
A
L
D
K
V
------------------------
M
L
K
F
M
R
Q
---------------------------------------------------------------------------------------
G
T
S
V
E
-
L
R
-----
G
L
N
A
A
S
A
T
L
V
E
------
R
L
-----------------------------------
5
Fugue
46.12
18%
-79
- C2 -
2W1R
-
SP5T_BACSU
A:
[57-173]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
A
K
E
-
Y
A
D
A
L
Y
D
S
L
G
H
-----------------
S
V
L
I
C
D
R
D
V
Y
I
A
V
S
G
S
S
-
K
K
D
Y
L
N
K
S
I
-
S
E
M
L
E
--
R
T
M
D
Q
R
S
S
V
L
E
S
D
A
K
S
V
Q
L
V
N
G
I
D
E
D
M
N
S
-
Y
T
V
G
P
I
V
A
N
G
D
P
I
G
A
V
V
I
F
----
S
K
-
D
Q
T
M
G
E
V
E
H
K
--------
A
V
E
T
A
A
G
F
L
----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
43.04
19%
-33
- C3 -
1B3Q
-
CHEA_THEMA
A:
[62-251]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------
M
V
P
I
S
F
V
F
N
R
F
P
R
M
V
R
D
L
A
K
K
M
---------------------
N
------
K
E
V
N
F
I
---
M
R
G
E
D
---
T
---
E
L
---
D
R
T
F
V
E
E
I
G
E
P
L
L
H
-----
L
L
R
N
A
I
D
H
G
I
E
P
K
E
E
R
I
A
K
GK
P
P
I
-------
G
-------
T
L
I
L
S
A
R
------
H
--
E
G
N
-
N
V
V
I
E
V
E
D
D
G
R
G
I
D
K
E
K
I
I
R
K
A
I
E
KGLIDE
S
K
A
A
T
LS
D
Q
E
I
L
N
F
L
F
V
P
G
F
---
S
--------------------------
G
V
G
M
D
V
V
K
N
V
----------------
V
E
-
S
L
N
G
S
---
M
G
I
---------
E
S
E
K
D
K
G
T
K
V
T
-
I
R
-----
L
P
L
T
L
A
I
I
C
A
L
------
L
V
K
V
---------------------------------
8
Fugue
40.93
13%
-32
- C3 -
1ID0
2
A:
[1-146]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
L
H
P
V
A
P
L
L
D
N
L
T
S
A
L
N
K
V
Y
Q
---------------------
R
------
K
G
V
N
I
S
---
L
D
I
S
P
---
E
---
I
----
S
---
F
V
G
E
Q
N
D
F
V
E
-----
V
M
G
N
V
L
D
N
A
C
K
Y
----------
C
L
-------
E
-------
F
V
E
I
S
A
R
------
Q
--
T
D
E
-
H
L
Y
I
V
V
E
D
D
G
P
G
I
P
L
S
K
------------------------
R
E
V
I
F
D
R
G
Q
RVD
T
L
-------
R
-------------
P
-
G
Q
G
V
G
L
A
V
A
R
E
I
----------------
T
E
-
Q
Y
E
G
K
I
V
A
G
E
-----------
S
M
-
L
G
G
A
R
M
E
-
V
I
-----
F
G
R
Q
H
-------------------------------------------------
25
HHSearch
40.08
13%
-25
- C3 -
1ID0
2
A:
[2-146]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------
L
H
P
V
A
P
L
L
D
N
L
T
S
A
L
N
K
V
Y
Q
R
-----------------------------
K
G
V
N
I
S
---
L
D
I
S
P
---
E
---
I
S
F
V
G
E
---
Q
N
D
F
V
E
V
M
G
N
-----
V
L
D
N
A
C
K
Y
C
------------
L
E
----------------
F
V
E
I
S
A
R
------
Q
--
T
D
E
-
H
L
Y
I
V
V
E
D
D
G
P
G
I
P
L
S
K
------------------------
R
E
V
I
F
D
R
G
Q
---
R
V
-------
D
TLR----------
P
-
G
Q
G
V
G
L
A
V
A
R
E
I
----------------
T
E
-
Q
Y
E
G
K
---
I
V
A
---------
G
E
S
M
L
G
G
A
R
M
E
-
V
I
-----
F
G
R
Q
H
-------------------------------------------------
23
HHSearch
39.57
17%
-23
- C3 -
3A0Y
-
?
A:
[607-752]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------
E
F
N
L
N
E
L
I
R
E
V
Y
V
L
F
E
E
K
I
R
-----------------------
K
------
M
N
I
D
F
C
---
F
E
T
D
N
---
E
DLR
V
EA--
D
---
R
T
R
I
K
Q
V
L
I
N
-----
L
V
Q
N
A
I
E
A
T
------------
G
E
N
-------
G
-------
K
I
K
I
T
S
E
------
D
--
M
Y
T
-
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
------------------------
K
E
K
I
F
S
P
F
F
---
T
T
-------
K
---------------
G
T
G
L
G
L
S
I
C
R
K
I
----------------
I
E
D
E
H
G
G
K
---
I
W
T
---------
E
N
R
-
E
N
G
V
V
F
I
-
F
E
-----
I
P
K
T
P
-------------------------------------------------
18
HHSearch
39.48
17%
-15
- C3 -
2Q8G
1
PDK1_HUMAN
A:
[114-367]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
I
R
N
R
H
N
D
V
I
P
T
M
A
Q
G
V
I
E
Y
K
E
S
FDPVT
S
Q
N
V
Q
Y
F
L
D
R
F
Y
M
S
-----------------------------
R
I
------
S
I
R
M
L
L
N
Q
H
S
L
L
F
G
-------------
K
HIGSINP
N
C
N
V
L
E
V
I
K
D
G
Y
E
N
A
R
R
L
C
D
L
Y
---------------------
Y
I
N
S
---
P
E
L
E
L
E
E
L
N
A
K
S
P
G
Q
--
P
I
Q
-
V
VY--
V
---
P
S
H
L
Y
H
M
V
F
E
-----
L
F
K
N
A
M
R
A
T
------------
M
E
H
H
ANRG
V
Y
P
-------
P
I
Q
V
H
V
T
------
L
--
G
N
E
-
D
L
T
V
K
M
S
D
R
G
G
G
V
P
L
R
K
------------------------
I
D
R
L
F
N
Y
M
Y
---
S
T
-------
A
PRPRVETSRAVPL
A
-
G
F
G
Y
G
L
P
I
S
R
L
Y
----------------
A
Q
-
Y
F
Q
G
D
---
L
K
L
---------
Y
S
L
E
G
Y
G
T
D
A
V
-
I
Y
-----
I
K
A
L
S
T
D
S
I
E
R
------
L
P
V
Y
---------------------------------
30
HHSearch
39.09
30%
-33
* C3 *
3EHG
10
A:
[37-125]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---
E
N
I
L
S
M
C
L
K
E
-----
A
V
T
N
V
V
K
H
S
-------------
Q
A
-------
K
-------
T
C
R
V
D
I
Q
------
Q
--
L
W
K
-
E
V
V
I
T
V
S
D
D
G
T
F
K
G
E
E
N
---------------------------------------------
S
-------------
F
-
S
K
G
H
G
L
L
G
M
R
E
R
----------------
L
E
-
F
A
N
G
S
---
L
H
I
---------
D
T
E
--
N
G
T
K
L
T
-
M
A
-----
I
P
N
---------------------------------------------------
16
HHSearch
38.89
16%
-7
- C3 -
2E0A
2
PDK4_HUMAN
A:
[97-354]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
F
V
D
T
L
-
I
K
V
R
N
R
H
H
N
V
V
P
T
M
A
Q
G
-------------------------
I
I
E
Y
K
D
A
C
T
V
D
PVTN
Q
N
L
Q
Y
F
L
D
R
F
Y
M
N
R
I
S
T
------
R
M
L
-
M
N
Q
H
I
L
I
F
S
D
S
Q
T
G
N
P
SHIGS
I
D
P
-------
N
C
D
V
V
A
V
V
Q
D
A
F
E
C
S
R
M
L
C
D
Q
Y
---------------------
Y
L
S
S
P
E
L
K
L
T
Q
V
N
---
G
K
F
P
D
Q
P
I
H
---
I
VY--
V
---
P
S
H
L
H
H
M
L
F
E
-----
L
F
K
N
A
M
R
A
T
------------
V
E
H
-------
Q
E
NQP
S
L
T
P
I
E
V
I
V
V
------
L
--
G
K
E
-
D
L
T
I
K
I
S
D
R
G
G
G
V
P
L
R
I
------------------------
I
D
R
L
F
S
Y
T
Y
---
S
T
APTPNAP
L
-------------
A
-
G
F
G
Y
G
L
P
I
S
R
L
Y
----------------
A
K
-
Y
F
Q
G
D
---
L
N
L
---------
Y
S
L
S
G
Y
G
T
D
A
I
-
I
Y
-----
L
K
A
L
S
S
E
S
I
E
K
------
L
P
V
F
---------------------------------
28
HHSearch
38.49
19%
-17
- C3 -
3SL2
2
A:
[40-153]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
---
Q
D
K
I
T
Q
V
L
D
N
-----
I
I
S
N
A
L
K
Y
S
------------
P
E
G
-------
G
-------
H
V
T
F
S
I
D
------
V
NE
E
E
E
-
L
L
Y
I
S
V
K
D
E
G
I
G
I
P
K
K
D
------------------------
V
E
K
V
F
D
R
F
Y
---
R
V
D------
L
-------------
G
-
G
T
G
L
G
L
A
I
A
K
E
M
----------------
V
Q
-
A
H
G
G
D
---
I
W
A
---------
D
S
I
E
G
K
G
T
T
I
T
-
F
T
-----
L
P
Y
K
E
-------------------------------------------------
15
HHSearch
38.40
16%
-31
- C3 -
3A0R
1
?
A:
[135-347]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
A
R
V
-
A
H
E
I
R
N
P
I
T
I
I
G
G
F
I
M
R
MKKHLDDPETLKKYI
N
I
I
T
N
-----
E
-----------------------------
L
S
------
R
L
E
T
I
V
K
E
I
L
E
Y
S
K
E
R
-
V
-
L
-----
E
F
T
-------
E
F
N
L
N
E
L
I
R
E
V
Y
V
L
F
E
E
K
I
R
K
-----------------------------
M
N
I
D
F
C
---
F
E
T
D
N
---
E
D
L
R
V
E
A--
D
---
R
T
R
I
K
Q
V
L
I
N
-----
L
V
Q
N
A
I
E
A
T
------------
G
E
N
-------
G
-------
K
I
K
I
T
S
E
------
D
--
M
Y
T
-
K
V
R
V
S
V
W
N
S
G
P
P
I
P
E
E
L
------------------------
K
E
K
I
F
S
P
F
F
---
T
T
--------------------------
L
G
L
S
I
C
R
K
I
----------------
I
E
-
D
E
H
G
G
K
--
I
W
T
---------
E
N
R
-
E
N
G
V
V
F
I
-
F
E
-----
I
P
K
T
P
E
K
R
----------------------------------------------
21
HHSearch
37.33
18%
-1
- C3 -
3JZ3
-
QSEC_ECOLI
A:
[40-214]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A
L
L
Q
L
H-------------------
G
-----------------------------
I
D
------
R
A
T
R
L
V
D
Q
L
L
T
L
S
R
L
D
S
L
D
N
LQ---
D
V
A
-------
E
I
P
L
E
D
L
L
Q
S
S
V
M
D
I
Y
H
T
A
Q
-----------------------
Q
------
A
K
I
D
V
R
---
L
T
L
N
A
---
H
S
I
K
R
T
G--
Q
---
P
L
L
L
S
L
L
V
R
N
-----
L
L
D
N
A
V
R
Y
S
------------
P
Q
G
-------
S
-------
V
V
D
V
T
L
N
------
A
--
D
-----
N
F
I
V
R
D
N
G
P
----------------------------------------------------------------------
L
G
L
S
I
V
Q
R
I
----------------
A
K
-
L
H
G
M
N
---
V
E
F
---------
G
N
A
E
Q
G
G
F
E
A
K
-
V
S
-----
W
L
E
H
--------------------------------------------------
7
Fugue
37.29
22%
-29
- C3 -
3EHG
11
A:
[1-125]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
R
L
K
D
E
L
I
N
I
K
Q
I
L
E
A
A
D
I
M
F
---------------------
I
------
Y
E
E
E
K
W
---
P
E
N
I
S
---
L
---
L
----
N
---
E
N
I
L
S
M
C
L
K
E
-----
A
V
T
N
V
V
K
H
S
-------------
Q
A
-------
K
-------
T
C
R
V
D
I
Q
------
Q
--
L
W
K
-
E
V
V
I
T
V
S
D
D
G
T
F
K
G
E
E
--------------------------------------
N
-------
S
-------------
F
-
S
K
G
H
G
L
L
G
M
R
E
R
----------------
L
E
-
F
A
N
G
S
L
H
I
D
-------------
T
-
E
N
G
T
K
L
T
-
M
A
-----
I
P
N
---------------------------------------------------
24
HHSearch
37.10
30%
-32
- C3 -
3EHH
2
DESK_BACSU
A:
[127-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
---
E
N
I
L
S
M
C
L
K
E
-----
A
V
T
N
V
V
K
H
S
-------------
Q
A
-------
K
-------
T
C
R
V
D
I
Q
------
Q
--
L
W
K
-
E
V
V
I
T
V
S
D
D
G
T
F
K
G
-------------------------------------------------------------------
H
G
L
L
G
M
R
E
R
----------------
L
E
-
F
A
N
G
S
---
L
H
I
---------
D
T
E
--
N
G
T
K
L
T
-
M
A
-----
I
P
N
---------------------------------------------------
11
Fugue
36.89
18%
-37
- C1 -
4QCC
-
DGOA_ECOLI
A:
[5-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
K
--
L
P
L
I
A
I
L
R
G
I
T
P
D
E
A
L
A
H
V
G
A
V
I
D
A
--
G
F
----------------
D
A
V
E
I
P
L
N
S
P
--------
Q
W
E
Q
S
I
P
A
I
V
D
A
Y
G
D
K
--
A
L
I
G
A
G
T
--
V
L
K
P
E
Q
V
D
A
-
L
A
R
M
G
C
Q
-----
L
I
V
T
P
N
I
H
S
E
V
I
R
R
A
V
G
Y
GMTV
C
P
G
C
A
T
A
T
E
A
F
T
A
--------
L
E
A
G
A
Q
A
L
K
IFPS
S
A
F
G
P
Q
Y
I
K
A
L
K
A
V
-----
L
P
S
D
I
A
V
F
A
V
G
-
G
V
T
P
E
N
L
A
Q
W
I
D
A
G
C
A
G
A
G
L
-------------------------
G
-----------------------------
S
D
LYRAGQ
S
V
E
R
T
A
Q
Q
A
A
A
F
V
K
A
Y
R
E
A
Q
-----
K
Q
K
-------
E
Q
R
Q
D
Q
K
S
A
Y
A
L
G
A
S
L
G
R
Y
M
E
N
---------------------
S
------
L
K
E
Q
E
K
---
L
G
I
K
L
---
D
---
K
----
D
---
Q
L
I
A
G
V
Q
D
A
F
A
DKSK
L
S
D
Q
E
I
E
Q
T
L
Q
A
F
--------
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
36.16
15%
-15
- C3 -
1YSR
3
PRRB_MYCTU
A:
[6-149]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------
P
V
D
I
T
D
L
L
D
R
A
A
H
D
A
A
R
I
Y
-------------------------------
P
D
L
D
V
S
---
L
V
P
S
P
---
T
C
I
-
I
V
G
--
L
---
P
A
G
L
R
L
A
V
D
N
-----
A
I
A
N
A
V
K
H
G
-------------
G
A
-------
T
-------
L
V
Q
L
S
A
V
------
S
--
S
R
A
-
G
V
E
I
A
I
D
D
N
G
S
G
V
P
E
G
E
------------------------
R
Q
V
V
F
E
R
F
S
-------------------------------
L
G
L
A
L
V
A
Q
Q
----------------
A
Q
-
L
H
G
G
T
---
A
S
L
---------
E
N
S
P
L
G
G
A
R
L
V
-
L
R
-----
L
P
G
P
S
-------------------------------------------------