@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0185: (2015-11-29 )
MKHITTVVIWKILRCLSLVFGVSILTFILLKQSPVDPVMASVNYDTSLTPVQYKAIAHHYGLDKPAPVQYFIWLKNFIQGHLGTSLVYRQPVIDIIRSRAGASFILMGLSWVLSGLIGFILGTLSAFHQGKLLDRIVRWFSYLQISVPTFWIGLIFLLIFSVQLGWFPIGISSPIGTLSQDITLADRIKHLILPVFTLSILGIANVTLHTRTKMMSVLSSEYVLFARARGETEWQIFKNHCLRNAIVPAITLHFSYFGELFGGSVLAEQVFSYPGLGSTLTEAGLKSDTPLLLAIVMIGTLFVFAGNLIADILNSIINPQLRRKV
Atome Classification :
(20 SA)
------------------------------------------------------------------------........--------.----10-.------.......----20--------.-......--..30...-------.....40..------.---...-..50........60........70..---......80.--..------.....90----.....-----...100-------.........110.....---.----------.120......------------.------130..-..-...140----------.......150.......----------160..-.------....-----170...----------------..-..180..--.....190-------.-..-...---------------...200---.-.......------210.......220-.........230.....----..240.....-..-250.-----------......260-........270.-.-..-------------....280..---.----..-..290..----.-....300......--.310.......320...----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------MK
H
I
T
T
V
V
--------
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----
W
K
-
I
------
L
R
C
L
S
L
V
----
F
---------
G
-
V
S
I
L
T
F
--
I
L
LKQSP-------VD
P
V
M
A
SVN------Y---DTS-LT
P
V
Q
Y
K
A
I
A
H
HYGLDKPA
P
V
Q
Y
F
I
W
---
L
K
N
F
I
Q
G
HL--GT------S
L
V
YR
Q
P
----
V
I
D
I
I
-----
R
S
RA---------G
A
S
F
I
L
M
G
L
S
W
V
L
S
G
L
I
---
G
----------
F
I
L
G
T
L
S
A
F
H
------------
Q
------
G
K
L
L
D
-
R
I
-
V
R
W
F
S
Y
----------
L
QIS
V
P
T
F
W
I
G
L
I
F
L
L
I
----------
F
S
VQL-G------
W
F
P
I-----GISSP
I
----------------
G
T
-
L
S
QD
I
T
L
--
A
D
R
I
K
H
---------
L
-
I
L
-
P
V
F
---------------
T
L
S
I
L
----G-I
A
N
V
T
L
H
------
T
R
T
K
M
M
S
V
L
SS---E
Y
V
L
F
A
RARGE
T
E
W
Q
I
F
----
K
N
H
C
L
R
N
AIV-
P
A
-
I
T
L
H
-----------
F
S
Y
F
G
E
L-F-
G
G
S
V
L
A
E
Q
V
F-S-Y-PG-------------LG
S
T
L
T
EAG---L----KS-DT
P
L
L
L
A
----
I
-
V
M
I
G
T
L
F
V
F
A
G
N
L
--
I
A
D
I
L
N
S
II
N
P
Q
L
RRKV----------------------------------
24
Fugue
90.32
18%
-157
- C3 -
4X2Z
1
A:
[9-309]
------------------------------------------------------------------------
Q
K
T
I
Y
L
T
E
--------
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----
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V
-
K
------
Y
R
S
I
V
L
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----
P
---------
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-
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G
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Y
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N
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I
-------
V
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A
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D
V
E
D
------
K
---
E
I
L
-
Y
V
P
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Y
Y
G
L
D
A
Q
K
Y
V
I
Y
L
Q
T
---
L
A
Q
K
W
N
---------------
V
Q
Y
R
D
----
N
F
L
I
L
-----
E
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R
D
---------
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N
C
W
I
S
S
A
I
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A
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R
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----------
F
L
T
E
A
W
A
K
L
L
------------
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------
G
D
P
T
D
-
F
V
-
A
W
C
Y
A
S
----------
C
T
A
K
V
G
D
F
S
D
A
N
W
L
L
A
N
----------
L
A
E
H
F
-
D
ADYTNA
F
L
K
K
-----
R
V
S
C
N
C
----------------
G
I
-
K
S
Y
E
L
R
-----
G
L
E
A
---------
C
-
I
Q
-
P
V
R
---------------
A
T
N
L
L
----
H
-
F
K
T
Q
Y
S
N
C
PTCG
A
N
N
T
D
E
V
I
E
A
S
L
---
P
Y
L
L
L
F
A
T
D
G
P
A
T
V
D
---------
C
D
E
D
A
V
G
-
T
V
-
V
F
V
G
-----------
S
T
N
S
G
H
C
-
Y
---
T
Q
A
A
G
Q
A
F
-
D
-
N
-
L
A
-------------
K
D
R
K
F
G
K
-------------
K
S
P
Y
I
T
A
M
---
Y
-
T
--
R
F
A
F
K
N
E
T
S
------------------------------------------------------
23
Fugue
83.66
16%
-132
- C4 -
3ZPJ
-
?
A:
[1-356]
---------------------------------------------------------------------M
T
T
L
E
E
I
N
L
L
V
E
R
GY
Y
E
E
A
L
----
A
K
-
V
------
Y
E
I
E
D
P
I
----
E
---------
Q
-
V
Q
V
L
T
K
--
I
V
V
T
I
Y
Q
H
DGPMEW
I
P
S
I
M
E
D
A
M
------
Y
---
I
A
K
K
L
R
D
P
A
N
K
A
V
A
Y
S
I
I
A
S
T
L
A
I
M
E
Y
E
E
D
---
A
M
D
F
F
N
R
A
I
--
D
E
A
N
E
IES
P
I
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V
----
L
S
T
L
A
-----
Y
H
L
A
---------
I
A
G
Y
P
D
N
A
L
E
I
F
N
I
A
F
D
---
T
----------
I
I
G
A
E
T
S
Y
T
H
------------
K
------
V
D
G
I
L
-
R
I
-
G
D
L
L
E
K
----------
A
G
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L
P
S
N
E
A
M
D
F
Y
K
M
A
----------
F
D
I
----------
F
D
K
L
-----
H
V
N
Q
R
A
----------------
A
I
-
V
E
K
K
I
E
L
--
A
K
T
V
Y
D
---------
V
-
G
L
-
P
Q
I
---------------
R
A
A
L
L
----
K
-------
G
------
K
N
H
Y
A
L
A
I
I
K
K
---
K
Y
S
G
V
M
R
L
I
G
E
L
E
V
A
L
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M
K
R
V
N
N
M
E
Y
L
D
V
V
D
-
K
A
-
F
E
C
C
-----------
E
S
P
R
F
T
D
-
V
-
N
V
Q
H
I
A
R
L
L
T
-
E
-
L
-
G
N
-------------
L
R
R
A
L
K
F
A
K
E
--
I
----
Q
N
-
I
H
K
R
S
E
A
----
L
-
K
A
I
A
L
E
L
V
R
R
K
K
F
EE
V
K
K
I
I
E
S
I
P
D
P
K
I
R
E
E
A
L
N
E
I
GTIE--------------------------
22
Fugue
83.10
18%
-112
- C6 -
4NM6
7
A:
[7-451]
-------------------------------------------------------SCRCE
G
P
F
Y
T
HLGAGPN
V
A
A
I
R
E
I
M
--------
E
----
E
R
-
F
GQKGKA
I
R
I
E
R
V
I
----
Y
TG
K
E
G
K
S
SQ
G
-
C
P
I
A
K
W
--
V
V
R
R
S
S
S
-------
E
E
K
L
L
C
L
V
R
------
E
RAG
H
T
C
-
E
A
A
V
I
V
I
L
I
L
V
W
E
G
I
P
L
S
L
A
D
K
L
Y
S
E
---
L
T
E
T
L
R
K
Y
----
G
------
T
L
T
N
R
R
C
----
A
L
N
E
E
-----
R
T
C
A
CQGLDPET
C
G
A
S
F
S
F
-
G
C
S
W
S
M
Y
Y
N
G
---
C
KFARSKIPRK
F
K
L
L
G
D
D
P
K
E
------------
E
------
E
K
L
E
S
-
H
L
-
Q
N
L
S
T
L
----------
M
A
P
T
Y
K
K
L
A
P
D
A
Y
N
N
Q
I
E
YEHRAPECR
L
G
L
K
E
-
G
------
R
P
F
S
-----
G
V
T
A
C
L
D
F
C
A
H
AHRDLHNMQN
G
S
T
-
L
V
C
T
L
T
R
--
E
D
N
R
E
F
G
G
K
P
ED
E
Q
L
H
-
V
L
-
P
L
Y
---------------
K
V
S
D
V
DEFG
S
-
V
E
A
Q
E
E
K
------
K
R
S
G
A
I
Q
V
L
S
S
F
R
R
K
V
R
M
L
A
E
P
V
K
T
G
S
D
E
V
W
----
S
D
--------------
S
E
-----------
Q
S
F
L
D
P
D
-
I
-
G
G
V
A
V
A
---------
P
T
-------------
H
G
S
I
L
I
E
C
A
KR
E
L
----
H
A
-
T
T
P
L
K
N
P
NRNH
P
-
T
R
I
S
L
V
F
Y
Q
H
K
S
M
--
N
E
P
K
H
G
L
A
L
W
E
A
K
M
A
E
K
----------------------------------
11
HHSearch
77.84
17%
-114
- C10 -
3RLF
2
MALF_ECOLI
F:
[273-503]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
K
P
F
-----
L
A
I
F
---------
V
W
T
V
V
F
S
L
I
T
V
F
L
T
V
A
V
---
G
----------
M
V
L
A
C
L
V
Q
W
E
------------
A
-------
L
R
G
K
-
A
V
-
Y
R
V
L
L
I
----------
L
P
Y
A
V
P
S
F
I
S
I
L
I
F
K
G
L
----------
F
N
Q
S
F
-
G
------
E
I
N
M
MLSAL
F
G
V
K
------------------------
P
A
W
F
--
S
D
P
T
T
A
---------
R
-
T
M
-
L
I
I
---------------
V
N
T
W
L
----
G
-
Y
P
Y
M
M
I
L
------
C
M
G
-
L
L
K
A
I
P
D
---
D
L
Y
E
A
S
A
M
D
G
A
G
P
F
Q
N
F
----
F
K
I
T
L
P
L
L
I
K
-
P
L
-
T
P
L
M
-----------
I
A
S
F
A
F
N
-
F
-
N
N
F
V
L
I
Q
L
L
T
-
N
G
G
-
P
D
RLGTTTPAGYTDL
L
V
N
Y
T
Y
R
I
A
---
F
EGGG
G
Q
-
D
F
G
L
A
A
A
----
I
-
A
T
L
I
F
L
L
V
G
A
L
A
I
-----------------------------------------------------
18
Fugue
73.40
20%
-114
- C10 -
4P4M
5
?
A:
[92-378]
------------------------------------------------------------------K
P
K
L
K
A
I
Q
E
L
T
Q
V
H
--------
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----
F
G
-
P
------
R
A
A
A
A
L
F
----
D
---------
R
-
E
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I
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-----------------
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E
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A
D
------
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---
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Y
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L
---
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E
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E
K
C
--
M
E
------
V
L
-
G
K
D
F
----
S
I
L
I
C
-----
G
S
Y
R
---------
R
R
H
P
F
S
G
D
V
D
A
I
L
S
R
T
L
---
D
----------
A
P
P
L
S
E
P
V
A
A
------------
T
------
G
-
V
L
G
-
H
F
-
V
E
F
L
E
S
----------
L
K
Y
L
E
A
T
M
A
Q
G
P
L
--------------
K
Y
M
G
M
-
G
------
R
L
P
P
-----
R
I
N
T
K
V
----------------
Y
K
A
R
R
V
D
I
R
L
--
I
E
---
T
---------
K
-
S
V
-
P
T
A
---------------
M
L
T
F
T
----
G
-
S
K
N
F
N
V
I
------
M
R
Q
A
A
I
S
---
K
---
G
Y
L
L
-------
N
E
Y
G
L
F
----
K
L
G
T
P
E
E
A
---------
R
-----------
G
K
N
A
G
E
E
-
L
-
G
------------
V
-
P
K
-------------
D
E
L
E
D
K
R
V
E
---
V
----
R
S
-
E
Q
D
V
F
D
V
----
L
-
G
M
-------------------
P
Y
A
K
P
E
N
R
D
P
-----------------------------------
8
HHSearch
69.36
15%
-119
- C10 -
3TUI
-
METI_ECOLI
A:
[2-216]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
P
----
M
M
W
L
L
-----
V
R
G
V
---------
W
E
T
L
A
M
T
F
V
S
G
F
F
G
F
V
I
---
G
----------
L
P
V
G
V
L
L
Y
V
T
------------
R
PGQIIA
N
A
K
L
Y
-
R
T
-
V
S
A
I
V
N
----------
I
F
R
S
I
P
F
I
I
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L
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W
M
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F
----------
T
R
V
I
V
------------------
G
----------------------------------
T
S
I
G
---------
L
-
Q
A
-
A
I
V
---------------
P
L
T
V
G
----
A
-
A
P
F
I
A
R
M
------
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E
N
-
A
L
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E
I
P
T
---
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L
I
E
A
S
R
A
M
G
A
T
P
M
Q
I
V
----
R
K
V
L
L
P
E
A
L
P
-
G
L
-
V
N
A
A
-----------
T
I
T
L
I
T
L
-
V
-
G
Y
S
A
M
G
G
-
A
V
-
G
-
A
-
G
G
-------------
L
G
Q
I
G
Y
Q
Y
G
---
Y
----
I
G
Y
N
A
T
V
M
N
T
----
V
-
L
V
L
L
V
I
L
V
Y
L
I
Q
F
--
A
G
D
R
I
V
R
A
V
T
R
----------------------------------------
26
Fugue
66.76
21%
-75
- C7 -
4FYP
1
VSP1_ARATH
A:
[34-261]
------------------------------------------------------------------------
G
L
S
I
N
Y
-------------------------
P
N
C
R
S
W
H
----
L
---------
G
-
V
E
T
S
N
I
--
I
N
F
D
T
V
P
------------------------------------------------------
A
N
---
C
K
A
Y
V
E
D
Y
L
--
I
T
------
S
---
K
Q
Y
----
Q
Y
D
S
K
-----
T
V
N
K
---------
E
A
Y
F
Y
A
K
G
L
A
L
K
N
D
T
V
N
---
V
----------
W
I
F
D
L
-----------------
D
------
D
T
L
L
S
-
S
I
-
P
Y
Y
A
K
Y
----------
G
Y
G
T
E
N
T
A
P
-------------------
G
A
Y
W
-
S
------
W
L
E
S
-----
G
E
S
T
P
------------------
G
-
L
P
E
T
L
H
L
--
Y
E
N
L
L
E
---------
L
G
I
E
-
P
I
I
---------------
I
S
D
R
W
----
K
-
K
L
S
E
V
T
V
------
E
N
L
K
A
V
G
V
T
K
W
---
K
H
L
I
L
K
P
N
G
S
K
L
T
Q
V
V
Y
----
K
S
K
-
V
R
N
S
L
V
-
K
K
--------------------
G
Y
N
-
I
-
V
G
N
I
G
D
Q
-----------------------------
W
A
D
---
L
----
V
E
-
D
T
P
-------------
G
R
V
F
K
L
P
-------
N
P
L
Y
Y
V
P
S
L
E
H
H
H
H
-----------------------------------
10
HHSearch
64.73
14%
-122
- C10 -
3D31
-
?
C:
[79-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
-----
I
S
S
I
---------
F
L
S
L
Y
A
G
F
L
A
T
L
L
A
L
L
L
---
G
----------
A
P
T
G
Y
I
L
A
R
F
------------
D
-------
F
P
G
K
-
R
L
-
V
E
S
I
I
D
----------
V
P
V
V
V
P
H
T
V
A
G
I
A
L
L
T
V
----------
F
G
S
-
R
-
G
------
L
I
G
E
-----
P
L
-
E
--------------------------
S
Y
--
I
Q
F
R
D
A
---------
L
-
P
G
-
I
V
V
---------------
A
M
L
F
V
----
S
-
M
P
Y
L
A
N
S
------
A
R
E
-
G
F
K
S
V
D
P
---
R
L
E
N
A
A
R
S
L
G
A
P
L
W
K
A
F
----
F
F
V
T
L
P
L
S
A
R
-
Y
L
-
L
I
G
S
-----------
V
M
T
W
A
R
A
-
I
-
S
E
F
G
A
V
V
I
L
A
Y
Y
-
P
-
M
V
-------------
G
P
T
L
I
Y
D
R
F
---
I
----
S
Y
-
G
L
S
A
S
R
P
----
I
-
A
V
L
L
I
L
V
T
L
S
I
F
L
--
V
I
R
------------------------------------------------
9
HHSearch
64.62
12%
-126
- C10 -
2ONK
-
WTPB_ARCFU
C:
[69-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
-----
W
K
V
V
---------
L
T
T
Y
Y
A
A
L
I
S
T
L
I
A
V
I
F
---
G
----------
T
P
L
A
Y
I
L
A
R
K
------------
S
-------
F
P
G
K
-
S
V
-
V
E
G
I
V
D
----------
L
P
V
V
I
P
H
T
V
A
G
I
A
L
L
V
V
----------
F
G
S
-
S
-
G
------
L
I
G
S
-----
F
S
P
-------------------------------
L
K
F
V
D
A
---------
L
-
P
G
-
I
V
V
---------------
A
M
L
F
V
----
S
-
V
P
I
Y
I
N
Q
------
A
K
E
-
G
F
A
S
V
D
V
---
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
----
F
T
V
S
L
P
L
S
V
R
-
H
I
-
V
A
G
A
-----------
I
M
S
W
A
R
G
-
I
-
S
E
F
G
A
V
V
V
I
A
-
Y
-
Y
P
M
I
-------------
A
P
T
L
I
Y
E
R
Y
---
L
----
S
E
-
G
L
S
A
A
M
P
----
V
-
A
A
I
L
I
L
L
S
L
A
V
F
V
--
A
L
R
I
I
V
G
--------------------------------------------
19
Fugue
63.39
14%
-118
* C10 *
2ONK
-
WTPB_ARCFU
C:
[24-275]
------------------------------------------------------------------------
M
R
L
L
F
S
A
L
--------
L
----
A
L
-
L
------
S
S
I
I
L
L
F
----
V
---------
L
-
L
P
V
A
A
T
--
V
T
L
Q
L
F
N
-------
F
D
E
F
L
K
A
A
S
------------------------------------------------------------------
D
P
A
----
V
W
K
V
V
-----
L
T
T
Y
---------
Y
A
A
L
I
S
T
L
I
A
V
I
F
G
T
P
L
---
A
----------
Y
I
L
A
R
K
S
F
P
G
-----------------------
K
-
S
V
-
V
E
G
I
V
D
----------
L
P
V
V
I
P
H
T
V
A
G
I
A
L
L
V
V
----------
F
G
S
S
--
G
------
L
--
I
-----
G
S
F
S
P
L
----------------
K
F
-
V
D
A
L
P
G
I
--
V
V
A
M
L
F
---------
V
-
S
V
-
P
I
Y
---------------
I
N
Q
A
K
----
E
-
G
F
A
S
-----------------
V
D
V
---
R
L
E
H
V
A
R
T
L
G
S
S
P
L
R
V
F
----
F
T
V
S
L
P
L
S
V
R
-
H
I
-
V
A
G
A
-----------
I
M
S
W
A
R
G
-
I
-
S
E
F
G
A
V
V
V
I
A
-
Y
-
Y
-
P
M
-------------
I
A
P
T
L
I
Y
E
R
---
Y
----
L
S
E
G
L
S
A
A
M
P
----
V
-
A
A
I
L
I
L
L
S
L
A
V
F
V
--
A
L
R
I
I
V
G
--------------------------------------------
21
Fugue
63.11
11%
-104
- C5 -
2R9R
13
KCNA2_RAT (first)
B:
[51-436]
-----------------------------------------------------S
E
R
V
V
I
N
I
SG
L
R
F
E
T
Q
L
K
T
L
A
Q
F
P
E
T
L
--------
L
----
G
D
-
P
------
K
K
R
M
R
Y
F
----
D
---------
P
-
L
R
N
E
Y
F
--
F
D
R
N
R
P
S
-------
F
D
A
I
L
Y
Y
Y
Q
S
G
G
R
L
R
R
---
P
V
N
-
V
P
L
D
I
F
S
E
E
I
R
F
Y
E
L
G
E
E
A
M
E
M
F
R
E
D
---
E
G
Y
I
K
E
E
E
R
--
P
L
------
P
E
N
E
F
Q
R
----
Q
V
W
L
L
F
E
YPE
S
S
G
P
---------
A
R
I
I
A
I
V
S
V
M
V
I
L
I
S
I
V
---
S
----------
F
C
L
E
T
L
P
I
F
R
DENEDMHGGGVT
F
------
H
T
Y
S
Q
-
S
T
-
I
G
Y
Q
Q
S
----------
T
S
F
T
D
P
F
F
I
V
E
T
L
C
I
I
W
----------
F
S
F
E
F
-
L
------
V
R
F
F
-----
A
C
P
S
K
A
----------------
G
F
-
F
T
N
I
M
N
I
--
I
D
I
V
A
I
---------
I
-
P
Y
-
Y
V
T
I
F
L
T
E
S
N
KS
V
L
Q
F
Q
N
V
R
R
V
V
----
Q
-
I
F
R
I
M
R
I
------
L
R
I
F
K
L
S
R
H
S
K
---
G
L
Q
I
L
G
Q
T
L
K
A
S
M
R
E
L
G
----
L
L
I
F
F
L
F
I
G
V
-
I
L
-
F
S
S
A
-----------
V
Y
F
A
E
A
D
-
E
-
R
D
S
Q
F
P
S
I
P
D
-
A
-
F
-
W
W
-------------
A
V
V
S
M
T
T
V
G
---
Y
----
G
D
-
M
V
P
T
T
I
G
----
G
-
K
I
V
G
S
L
C
A
I
A
G
V
L
--
T
I
A
L
P
V
P
V
I
V
S
N
F
N
Y
F
Y
H
R
E
T------------------------------
25
Fugue
54.98
13%
-86
- C9 -
1W5C
9
PSBD_THEEB
D:
[1-350]
---------------------------------------------------MTIAIG
R
A
P
A
E
RGWF
D
I
L
D
D
W
L
K
R
D
R
F
V
F
--------
V
GWSG
I
L
-
L
------
F
P
C
A
Y
L
A
----
L
---------
G
-
G
W
L
T
G
T
--
T
F
V
T
S
W
Y
-------
T
H
G
L
A
S
S
Y
L
------
E
---
G
C
N
-
F
L
T
V
A
V
S
T
P
A
N
S
M
G
H
S
-----
L
L
L
L
W
---
G
P
E
-------------------------------------
A
Q
G
D
---------
F
T
R
W
C
Q
L
G
G
L
W
T
F
I
A
L
H
---
G
----------
A
F
G
L
I
G
F
M
L
R
------------
Q
------
F
E
I
A
R
-
L
V
G
V
R
P
Y
N
A
----------
I
A
F
S
A
P
I
A
V
F
V
S
V
F
L
-
I
----------
Y
P
L
G
Q
-
S
------
S
W
F
F
-----
A
P
S
F
G
V
----------------
A
A
-
I
F
R
F
L
L
F
--
F
Q
G
F
H
N
---------
W
-
T
L
N
P
F
H
---------------
M
M
G
V
A
----
G
-
V
L
G
G
A
L
L
------
C
A
I
H
G
A
T
V
E
N
T
---
L
F
Q
D
G
E
G
A
S
T
F
R
A
F
N
P
T
----
Q
A
E
E
T
Y
S
-
M
V
-
T
A
-
N
R
F
W
-----------
S
Q
I
F
G
I
A
-
F
S
N
K
R
W
L
H
F
F
M
L
-
F
-
V
-
P
V
-------------
T
G
L
W
M
S
A
I
G
---
V
----
V
G
-
L
A
L
N
L
R
S
----
Y
-
D
F
I
S
Q
E
I
R
A
A
E
D
P
--
E
F
E
T
F
Y
T
K
N
L
L
L
N
E
G
I
R
A
W
M
APQDQPH
E
N
F
V
F
P
EEVLPRGN----------
27
Fugue
53.20
16%
-54
- C8 -
4OY2
1
TAF1_YEAST
A:
[10-502]
NL
N
I
Q
H
S
Q
P
A
I
N
LQSPFYKVAVP
R
Y
Q
L
R
H
FHRENFGSHIRPG
T
K
I
V
F
S
K
L
K
A
RKRKRDKGKD
V
K
E
S
F
STSQD
L
T
I
G
D
T
A
P
--------
V
----
Y
L
M
E
------
Y
S
E
Q
T
P
V
A
L
S
K
F
---------
G
M
A
N
K
L
I
N
--
Y
Y
R
K
A
N
E
-------
Q
D
T
L
R
P
K
L
P
------
V
G
--
E
T
H
-
V
L
G
V
Q
D
K
S
P
F
W
N
F
G
F
V
E
P
G
H
I
V
P
T
L
Y
N
NM
I
R
A
P
V
F
K
H
D
I
S
G
T
------
D
F
L
L
T
K
S
S
G
FG
I
S
N
R
F
-----
Y
L
R
N
---------
I
N
H
L
F
T
V
G
Q
T
F
P
V
E
E
I
P
---
G
------------
P
N
S
R
K
V
T
S
M
-----------
K
------
A
T
R
L
K
M
I
I
-
Y
R
I
L
N
H
N
HSKAISI
D
P
I
A
K
H
F
P
D
Q
D
Y
G
Q
N
R
Q
K
V
------------
K
E
F
M
K
------
Y
Q
R
D
-----
G
P
E
K
G
L
----------------
W
R
-
L
K
D
D
E
K
L
L
D
N
E
A
V
K
S
---------
L
-
I
T
-
P
E
Q
---------------
I
S
Q
V
E
----
S
M
S
Q
G
L
Q
F
Q
------
E
D
N
E
A
Y
N
F
------
D
S
K
L
K
S
L
E
E
N
L
L
P
W
N
I
T
----
K
N
--
F
I
N
S
T
Q
M
R
A
M
I
Q
I
H
GVGDPTGCGEG
F
S
F
L
K
T
S
M
K
-
H
S
Y
N
V
A
Q
Q
Q
K
-
A
-
Y
-
D
E
E
------------
I
A
K
T
W
Y
T
H
T
---
K
----
S
L
-
S
I
S
N
P
F
E
----
E
M
T
N
P
D
E
I
N
Q
T
N
K
H
V
--
K
T
D
R
D
D
K
K
I
L
K
I
V
R
K
K
R
DENG
I
I
Q
R
Q
T
I
F
I
RD
P
R
V
I
Q
G
Y
I
K
I
K
E
Q
D
K
EDVN
4
PsiBlast_PDB
44.10
43%
-79
- C10 -
1W4T
-
?
A:
[22-57]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
-
L
T
P
E
Q
T
H
A
Y
L
H
H
I
G
I
D
D
P
G
P
P
S
-
L
A
N
---
L
D
R
L
I
D
A
H
L
--
R
R
------
V
A
F
E
N
L
D
----
V
L
L
D
R
-----
P
I
E
I
---------
D
A
D
K
V
F
A
K
V
V
E
G
S
R
G
G
Y
---
C
----------
F
E
L
N
S
L
F
A
R
L
------------
L
------
L
A
L
G
Y
-
E
L
-
E
L
L
V
A
R
----------
V
R
W
G
L
P
D
D
A
P
L
T
Q
Q
S
H
L
----------
M
L
R
L
Y
-
L
------
A
E
G
E
-----
F
L
V
D
V
G
----------------
F
G
-
S
A
N
P
P
R
A
--
L
P
L
P
G
D
---------
E
-
A
D
-
A
G
Q
---------------
V
H
C
V
R
----
L
-
V
D
P
H
A
G
L
------
Y
E
S
A
V
R
G
R
S
G
W
---
L
P
L
Y
R
F
D
L
R
P
Q
L
W
I
D
Y
I
----
P
R
N
W
Y
T
S
T
H
P
-
H
S
-
V
F
R
Q
-----------
G
L
K
A
A
I
T
-
E
-
G
D
L
R
L
T
L
A
D
G
-
L
-
F
-
G
Q
-------------
R
A
G
N
G
E
T
L
Q
---
R
----
Q
L
-
R
D
V
E
E
L
L
----
D
-
I
L
Q
T
R
F
R
L
R
L
D
P
A
--
S
E
V
P
A
L
A
R
R
L
A
G
L
I
-------------------------------------
1
PsiBlast_PDB
39.06
36%
30
- C11 -
3FOA
-
TSP_BPT4
A:
[154-201]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
V
G
-
E
-
Y
-
P
T
-------------
L
G
S
N
W
T
-
A
E
---
I
----
S
S
-
S
S
S
G
L
A
A
----
V
-
I
T
L
G
K
I
I
T
D
S
G
I
L
--
L
A
E
I
E
N
A
E
A
A
M
T
A
V
D
F
Q
----------------------------------
6
PsiBlast_PDB
38.61
36%
30
* C11 *
3J2N
-
TSP_BPT4
U:
[154-201]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
V
G
-
E
-
Y
-
P
T
-------------
L
G
S
N
W
T
-
A
E
---
I
----
S
S
-
S
S
S
G
L
A
A
----
V
-
I
T
L
G
K
I
I
T
D
S
G
I
L
--
L
A
E
I
E
N
A
E
A
A
M
T
A
V
D
F
Q
----------------------------------
5
PsiBlast_PDB
37.99
36%
30
- C11 -
3J2M
-
TSP_BPT4
U:
[154-201]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
V
G
-
E
-
Y
-
P
T
-------------
L
G
S
N
W
T
-
A
E
---
I
----
S
S
-
S
S
S
G
L
A
A
----
V
-
I
T
L
G
K
I
I
T
D
S
G
I
L
--
L
A
E
I
E
N
A
E
A
A
M
T
A
V
D
F
Q
----------------------------------
2
PsiBlast_PDB
37.91
36%
30
- C11 -
3FOH
-
TSP_BPT4
A:
[154-201]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
V
G
-
E
-
Y
-
P
T
-------------
L
G
S
N
W
T
-
A
E
---
I
----
S
S
-
S
S
S
G
L
A
A
----
V
-
I
T
L
G
K
I
I
T
D
S
G
I
L
--
L
A
E
I
E
N
A
E
A
A
M
T
A
V
D
F
Q
----------------------------------
3
PsiBlast_PDB
37.74
36%
30
- C11 -
3FOI
-
TSP_BPT4
A:
[154-201]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
V
G
-
E
-
Y
-
P
T
-------------
L
G
S
N
W
T
-
A
E
---
I
----
S
S
-
S
S
S
G
L
A
A
----
V
-
I
T
L
G
K
I
I
T
D
S
G
I
L
--
L
A
E
I
E
N
A
E
A
A
M
T
A
V
D
F
Q
----------------------------------
7
PsiBlast_PDB
37.30
36%
29
- C11 -
3FO8
-
TSP_BPT4
D:
[72-119]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
V
G
-
E
-
Y
-
P
T
-------------
L
G
S
N
W
T
-
A
E
---
I
----
S
S
-
S
S
S
G
L
A
A
----
V
-
I
T
L
G
K
I
I
T
D
S
G
I
L
--
L
A
E
I
E
N
A
E
A
A
M
T
A
V
D
F
Q
----------------------------------