@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0195: (2015-11-29 )
MRCSTKEMRLVYRDFLLQANQENKQITVLEADLSSSMSTNVLASEFGKRYINLGIMEAEMVGLAAGLAIKGYKPYLHTFGPFASRRVFDQVFLSLGYSQLSATIIGSDAGVSAEMNGGTHMPFEELGLLRLIPKATIFEVSDDIQFEAILKQTLSIDGLKYIRTIRKAPTAVYEGCEDFSKGFIQLRQGKDIALVASGIMVSRAIEAADYLKELGIEASVIDLFKIKPLPEELKPLLIDQSIVTIENHNRIGGIGSALCEWLSMEKDTTVSRMGIDERFGQVGQMKYLLEEYGLAVKDIVEHCKSIYKS
Atome Classification :
(20 SA)
-------------.........10.......-.20........30...-....-----.-----------40.....-..-------------.50........60........70-.--..-....---..80........90.......-.100------.......110.......120.......130.......140.......150...-.-...160......------.170-.-.-..--...180..--.-.-.-..----..190.--........200.......210.......220.-----......230-----.--...-.---.---.--240-----........250.......260-.....-..270.......280.......290.......300.......--------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------MRC
S
T
K
E
M
R
L
V
Y
R
D
F
L
L
Q-ANQEN
K
Q
I
T
V
L
EADLS-SSMS-----
T
-----------
N
V
L
A
S
E
F
-
G
K
-------------
R
Y
I
NLG
I
M
E
A
E
M
V
G
L
AAGLAIK--G--YK-
P
Y
L
H---TFG
P
F
A
S
R
R
V
F
D
Q
V
F
L
S
L
G
Y
S
-
Q
L
S
A
------
T
I
IGSDAG
V
S
A
EMNGGTHM
P
F
E
EL
G
L
L
R
LIPK
A
T
I
F
EVSDD
I
Q
F
E
A
I
L
K
Q
T
LS-I-
D
G
L
K
Y
I
R
T
I
R
KA------
P
T
A
V
-
Y
-
E
-
G
C
--
E
D
F
S
--
K
G
--
F
-
I
-
Q
-LR----QGK--
D
--
I
A
L
V
ASG
I
M
V
S
R
A
I
E
A
A
D
Y
L
K
E
LGIE
A
S
V
I
D
L
-----
F
KIKP
L
P
E
E
-----
L
--
K
P
L
-L---I---D--
Q
S
------
I
V
T
IENHNRIG
G
I
G
S
A
L
C
E
W
L-SMEKD-T
T
V
S
RM
G
I
D
E
R
FGQ
V
G
Q
M
K
Y
L
L
E
EYG
L
A
V
K
D
I
V
E
H
C
K
S
I
YKS--------------
5
PsiBlast_PDB
96.43
29%
-96
- C4 -
4KXX
7
TKT_HUMAN
A:
[318-607]
---------------------
R
K
A
Y
G
Q
A
L
A
K
-
L
G
H
A
S
D
R
I
I
A
L
D
G
D
T
K
-
N
S
T
F
-----
S
-----------
E
I
F
K
K
E
H
-
P
D
-------------
R
F
I
E
C
Y
I
A
E
Q
N
M
V
S
I
A
V
G
C
A
T
R
--
N
--
R
T
V
P
F
C
S
---
T
F
A
A
F
F
T
R
-
A
F
D
Q
I
R
M
A
-
A
I
S
-
E
S
N
I
------
N
L
C
G
S
H
C
G
V
S
I
G
E
D
G
P
S
Q
M
A
L
E
D
L
A
M
F
R
S
V
P
T
S
T
V
F
Y
P
S
D
G
V
A
T
E
K
A
V
E
L
A
A
N
-
T
-
K
G
I
C
F
I
R
T
S
R
P
E
------
N
A
I
I
-
Y
-
N
-
N
N
--
E
D
F
Q
--
V
G
--
Q
-
A
-
K
V
V
L
----
K
S
K
--
D
DQ
V
T
V
I
G
A
G
V
T
L
H
E
A
L
A
A
A
E
L
L
K
K
E
K
I
N
I
R
V
L
D
P
-----
F
T
I
K
P
L
D
R
K
----------
L
-
I
---
L
---
D
--
S
A
R
A
T
KG
R
I
L
T
V
E
D
H
Y
Y
E
G
G
I
G
E
A
V
S
S
A
V
-
V
G
E
P
G
-
I
T
V
T
H
L
A
V
N
-
R
V
P
R
S
G
K
P
A
E
L
L
K
M
F
G
I
D
R
D
A
I
A
Q
A
V
R
G
L
I
T
---------------
4
PsiBlast_PDB
96.24
29%
-95
- C4 -
4KXW
6
TKT_HUMAN
A:
[318-607]
---------------------
R
K
A
Y
G
Q
A
L
A
K
-
L
G
H
A
S
D
R
I
I
A
L
D
G
D
T
K
-
N
S
T
F
-----
S
-----------
E
I
F
K
K
E
H
-
P
D
-------------
R
F
I
E
C
Y
I
A
E
Q
N
M
V
S
I
A
V
G
C
A
T
R
--
N
--
R
T
V
P
F
C
S
---
T
F
A
A
F
F
T
R
-
A
F
D
Q
I
R
M
A
-
A
I
S
-
E
S
N
I
------
N
L
C
G
S
H
C
G
V
S
I
G
E
D
G
P
S
Q
M
A
L
E
D
L
A
M
F
R
S
V
P
T
S
T
V
F
Y
P
S
D
G
V
A
T
E
K
A
V
E
L
A
A
N
-
T
-
K
G
I
C
F
I
R
T
S
R
P
E
------
N
A
I
I
-
Y
-
N
-
N
N
--
E
D
F
Q
--
V
G
--
Q
-
A
-
K
V
V
L
----
K
S
K
--
D
DQ
V
T
V
I
G
A
G
V
T
L
H
E
A
L
A
A
A
E
L
L
K
K
E
K
I
N
I
R
V
L
D
P
-----
F
T
I
K
P
L
D
R
K
----------
L
-
I
---
L
---
D
--
S
A
R
A
T
KG
R
I
L
T
V
E
D
H
Y
Y
E
G
G
I
G
E
A
V
S
S
A
V
-
V
G
E
P
G
-
I
T
V
T
H
L
A
V
N
-
R
V
P
R
S
G
K
P
A
E
L
L
K
M
F
G
I
D
R
D
A
I
A
Q
A
V
R
G
L
I
T
K
--------------
2
PsiBlast_PDB
96.21
29%
-95
- C4 -
4KXU
4
TKT_HUMAN
A:
[318-607]
---------------------
R
K
A
Y
G
Q
A
L
A
K
-
L
G
H
A
S
D
R
I
I
A
L
D
G
D
T
K
-
N
S
T
F
-----
S
-----------
E
I
F
K
K
E
H
-
P
D
-------------
R
F
I
E
C
Y
I
A
E
Q
N
M
V
S
I
A
V
G
C
A
T
R
--
N
--
R
T
V
P
F
C
S
---
T
F
A
A
F
F
T
R
-
A
F
D
Q
I
R
M
A
-
A
I
S
-
E
S
N
I
------
N
L
C
G
S
H
C
G
V
S
I
G
E
D
G
P
S
Q
M
A
L
E
D
L
A
M
F
R
S
V
P
T
S
T
V
F
Y
P
S
D
G
V
A
T
E
K
A
V
E
L
A
A
N
-
T
-
K
G
I
C
F
I
R
T
S
R
P
E
------
N
A
I
I
-
Y
-
N
-
N
N
--
E
D
F
Q
--
V
G
--
Q
-
A
-
K
V
V
L
----
K
S
K
--
D
DQ
V
T
V
I
G
A
G
V
T
L
H
E
A
L
A
A
A
E
L
L
K
K
E
K
I
N
I
R
V
L
D
P
-----
F
T
I
K
P
L
D
R
K
----------
L
-
I
---
L
---
D
--
S
A
R
A
T
KG
R
I
L
T
V
E
D
H
Y
Y
E
G
G
I
G
E
A
V
S
S
A
V
-
V
G
E
P
G
-
I
T
V
T
H
L
A
V
N
-
R
V
P
R
S
G
K
P
A
E
L
L
K
M
F
G
I
D
R
D
A
I
A
Q
A
V
R
G
L
I
T
---------------
1
PsiBlast_PDB
96.15
29%
-94
- C4 -
3MOS
5
TKT_HUMAN
A:
[316-605]
---------------------
R
K
A
Y
G
Q
A
L
A
K
-
L
G
H
A
S
D
R
I
I
A
L
D
G
D
T
K
-
N
S
T
F
-----
S
-----------
E
I
F
K
K
E
H
-
P
D
-------------
R
F
I
E
C
Y
I
A
E
Q
N
M
V
S
I
A
V
G
C
A
T
R
--
N
--
R
T
V
P
F
C
S
---
T
F
A
A
F
F
T
R
-
A
F
D
Q
I
R
M
A
-
A
I
S
-
E
S
N
I
------
N
L
C
G
S
H
C
G
V
S
I
G
E
D
G
P
S
Q
M
A
L
E
D
L
A
M
F
R
S
V
P
T
S
T
V
F
Y
P
S
D
G
V
A
T
E
K
A
V
E
L
A
A
N
-
T
-
K
G
I
C
F
I
R
T
S
R
P
E
------
N
A
I
I
-
Y
-
N
-
N
N
--
E
D
F
Q
--
V
G
--
Q
-
A
-
K
V
V
L
----
K
S
K
--
D
DQ
V
T
V
I
G
A
G
V
T
L
H
E
A
L
A
A
A
E
L
L
K
K
E
K
I
N
I
R
V
L
D
P
-----
F
T
I
K
P
L
D
R
K
----------
L
-
I
---
L
---
D
--
S
A
R
A
T
KG
R
I
L
T
V
E
D
H
Y
Y
E
G
G
I
G
E
A
V
S
S
A
V
-
V
G
E
P
G
-
I
T
V
T
H
L
A
V
N
-
R
V
P
R
S
G
K
P
A
E
L
L
K
M
F
G
I
D
R
D
A
I
A
Q
A
V
R
G
------------------
33
HHSearch
96.01
26%
-89
- C4 -
2O1S
2
DXS_ECOLI
A:
[319-620]
------------------
P
S
Y
S
K
I
F
G
D
W
L
C
E
-
T
A
A
K
D
N
K
L
M
A
I
T
P
A
M
R
-
E
G
S
G
-----
M
-----------
V
E
F
S
R
K
F
-
P
D
-------------
R
Y
F
D
V
A
I
A
E
Q
H
A
V
T
F
A
A
G
L
A
I
G
--
G
--
Y
K
-
P
I
V
A
---
I
Y
S
T
F
L
-
Q
R
A
Y
D
Q
V
L
H
D
V
A
I
Q
-
K
L
P
V
------
L
F
A
I
D
R
A
G
I
-
V
G
A
D
G
Q
T
H
Q
G
A
F
D
L
S
Y
L
R
C
I
P
E
M
V
I
M
T
P
S
D
E
N
E
C
R
Q
M
L
Y
T
G
Y
H
Y
N
-
D
G
P
S
A
V
R
Y
P
R
G
N
------
A
V
G
V
-
E
L
T
-
P
L
--
E
K
L
P
--
I
G
--
K
G
I
-
V
-
K
R
----
R
G
E
--
K
--
L
A
I
L
N
F
G
T
L
M
P
E
A
A
K
V
A
E
S
L
-----
N
A
T
L
V
D
M
-----
R
F
V
K
P
L
D
E
A
-----
L
--
I
L
E
-
M
---
A
A
S
-
H
--
E
A
------
L
V
T
V
E
E
N
A
I
M
G
G
A
G
S
G
V
N
E
V
L
-
M
A
H
R
K
P
V
P
V
L
N
I
G
L
P
D
F
F
I
P
Q
G
T
Q
E
E
M
R
A
E
L
G
L
D
A
A
G
M
E
A
K
I
K
A
W
L
A
---------------
6
PsiBlast_PDB
95.76
29%
-95
- C4 -
4KXY
10
TKT_HUMAN
A:
[318-607]
---------------------
R
K
A
Y
G
Q
A
L
A
K
-
L
G
H
A
S
D
R
I
I
A
L
D
G
D
T
K
-
N
S
T
F
-----
S
-----------
E
I
F
K
K
E
H
-
P
D
-------------
R
F
I
E
C
Y
I
A
E
Q
N
M
V
S
I
A
V
G
C
A
T
R
--
N
--
R
T
V
P
F
C
S
---
T
F
A
A
F
F
T
R
-
A
F
D
Q
I
R
M
A
-
A
I
S
-
E
S
N
I
------
N
L
C
G
S
H
C
G
V
S
I
G
E
D
G
P
S
Q
M
A
L
E
D
L
A
M
F
R
S
V
P
T
S
T
V
F
Y
P
S
D
G
V
A
T
E
K
A
V
E
L
A
A
N
-
T
-
K
G
I
C
F
I
R
T
S
R
P
E
------
N
A
I
I
-
Y
-
N
-
N
N
--
E
D
F
Q
--
V
G
--
Q
-
A
-
K
V
V
L
----
K
S
K
--
D
DQ
V
T
V
I
G
A
G
V
T
L
H
E
A
L
A
A
A
E
L
L
K
K
E
K
I
N
I
R
V
L
D
P
-----
F
T
I
K
P
L
D
R
K
----------
L
-
I
---
L
---
D
--
S
A
R
A
T
KG
R
I
L
T
V
E
D
H
Y
Y
E
G
G
I
G
E
A
V
S
S
A
V
-
V
G
E
P
G
-
I
T
V
T
H
L
A
V
N
-
R
V
P
R
S
G
K
P
A
E
L
L
K
M
F
G
I
D
R
D
A
I
A
Q
A
V
R
G
L
I
T
---------------
3
PsiBlast_PDB
95.61
29%
-94
- C4 -
4KXV
3
TKT_HUMAN
A:
[318-607]
---------------------
R
K
A
Y
G
Q
A
L
A
K
-
L
G
H
A
S
D
R
I
I
A
L
D
G
D
T
K
-
N
S
T
F
-----
S
-----------
E
I
F
K
K
E
H
-
P
D
-------------
R
F
I
E
C
Y
I
A
E
Q
N
M
V
S
I
A
V
G
C
A
T
R
--
N
--
R
T
V
P
F
C
S
---
T
F
A
A
F
F
T
R
-
A
F
D
Q
I
R
M
A
-
A
I
S
-
E
S
N
I
------
N
L
C
G
S
H
C
G
V
S
I
G
E
D
G
P
S
Q
M
A
L
E
D
L
A
M
F
R
S
V
P
T
S
T
V
F
Y
P
S
D
G
V
A
T
E
K
A
V
E
L
A
A
N
-
T
-
K
G
I
C
F
I
R
T
S
R
P
E
------
N
A
I
I
-
Y
-
N
-
N
N
--
E
D
F
Q
--
V
G
--
Q
-
A
-
K
V
V
L
----
K
S
K
--
D
DQ
V
T
V
I
G
A
G
V
T
L
H
E
A
L
A
A
A
E
L
L
K
K
E
K
I
N
I
R
V
L
D
P
-----
F
T
I
K
P
L
D
R
K
----------
L
-
I
---
L
---
D
--
S
A
R
A
T
KG
R
I
L
T
V
E
D
H
Y
Y
E
G
G
I
G
E
A
V
S
S
A
V
-
V
G
E
P
G
-
I
T
V
T
H
L
A
V
N
-
R
V
P
R
S
G
K
P
A
E
L
L
K
M
F
G
I
D
R
D
A
I
A
Q
A
V
R
G
L
I
T
---------------
7
PsiBlast_PDB
95.13
29%
-91
- C4 -
3OOY
4
TKT_HUMAN
A:
[314-603]
---------------------
R
K
A
Y
G
Q
A
L
A
K
-
L
G
H
A
S
D
R
I
I
A
L
D
G
D
T
K
-
N
S
T
F
-----
S
-----------
E
I
F
K
K
E
H
-
P
D
-------------
R
F
I
E
C
Y
I
A
E
Q
N
M
V
S
I
A
V
G
C
A
T
R
--
N
--
R
T
V
P
F
C
S
---
T
F
A
A
F
F
T
R
-
A
F
D
Q
I
R
M
A
-
A
I
S
-
E
S
N
I
------
N
L
C
G
S
H
C
G
V
S
I
G
E
D
G
P
S
Q
M
A
L
E
D
L
A
M
F
R
S
V
P
T
S
T
V
F
Y
P
S
D
G
V
A
T
E
K
A
V
E
L
A
A
N
-
T
-
K
G
I
C
F
I
R
T
S
R
P
E
------
N
A
I
I
-
Y
-
N
-
N
N
--
E
D
F
Q
--
V
G
--
Q
-
A
-
K
V
V
L
----
K
S
K
--
D
DQ
V
T
V
I
G
A
G
V
T
L
H
E
A
L
A
A
A
E
L
L
K
K
E
K
I
N
I
R
V
L
D
P
-----
F
T
I
K
P
L
D
R
K
----------
L
-
I
---
L
---
D
--
S
A
R
A
T
KG
R
I
L
T
V
E
D
H
Y
Y
E
G
G
I
G
E
A
V
S
S
A
V
-
V
G
E
P
G
-
I
T
V
T
H
L
A
V
N
-
R
V
P
R
S
G
K
P
A
E
L
L
K
M
F
G
I
D
R
D
A
I
A
Q
A
V
R
G
L
I
----------------
50
Fugue
93.77
25%
-90
- C4 -
1TRK
1
TKT1_YEAST
A:
[338-680]
LPANWESK
L
P
T
Y
T
A
K
D
S
A
V
A
T
R
K
L
S
E
T
V
L
E
D
-
V
Y
N
Q
L
P
E
L
I
G
G
S
A
D
L
T
P
S
N
L
T
-----
R
-----------
W
K
---
E
A
-
L
D
FQPPSSGSGNYSG
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
--
G
AN
Y
K
-
P
Y
G
G
T
F
L
N
F
V
S
Y
A
A
G
A
V
R
-
L
S
A
L
-----
S
G
H
P
V
------
I
W
V
A
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
T
L
A
H
F
R
S
L
P
N
I
Q
V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
L
E
-
S
-
K
H
T
P
S
I
I
A
L
S
R
Q
N
L
P
QLE-
G
S
S
-
I
-
E
------
S
A
S
--
K
G
--
G
-
Y
-
V
-
L
Q
----
D
V
A
NP
D
--
I
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
V
V
S
L
-----
P
D
F
F
T
F
D
K
Q
P
L
E
Y
R
L
--
S
V
L
-
P
---
D
---
N
--
V
P
------
I
M
S
V
E
V
L
A
T
T
--
C
W
G
K
Y
A
H
------------
Q
S
F
G
I
-
D
R
F
G
A
S
G
K
A
P
E
V
F
K
F
F
G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
Y
KG
D
K
L
I
SPLKKAF
9
PsiBlast_PDB
92.56
28%
-83
- C4 -
2O1S
2
DXS_ECOLI
A:
[324-606]
-----------------------
I
F
G
D
W
L
C
E
T
A
A
K
D
N
K
L
M
A
I
T
P
A
M
R
E
-
G
S
G
M
-----
V
-----------
E
-
F
S
R
K
F
-
P
D
-------------
R
Y
F
D
V
A
I
A
E
Q
H
A
V
T
F
A
A
G
L
A
I
G
--
G
--
Y
K
-
P
I
V
A
---
I
Y
S
T
F
L
-
Q
R
A
Y
D
Q
V
L
H
D
V
A
I
Q
-
K
L
P
V
------
L
F
A
I
D
R
A
G
I
V
G
-
A
D
G
Q
T
H
Q
G
A
F
D
L
S
Y
L
R
C
I
P
E
M
V
I
M
T
P
S
D
E
N
E
C
R
Q
M
L
Y
T
G
Y
H
-
Y
N
D
G
P
S
A
V
R
Y
P
R
G
N
------
A
V
G
V
E
L
-
T
-
P
L
--
E
K
L
P
IG
K
G
--
I
-
V
-
K
--
R
----
R
G
E
--
K
--
L
A
I
L
N
F
G
T
L
M
P
E
A
A
K
V
A
E
S
L
N
-----
A
T
L
V
D
M
-----
R
F
V
K
P
L
D
E
A
L
I
---
L
--
E
M
A
-
A
---
S
---
H
--
E
A
------
L
V
T
V
E
E
N
A
I
M
G
G
A
G
S
G
V
N
E
V
L
M
A
H
R
K
P
-
V
P
V
L
N
I
G
L
P
D
F
F
I
P
Q
G
T
Q
E
E
M
R
A
E
L
G
L
D
A
A
G
M
E
A
K
I
K
A
W
L
A
---------------
32
HHSearch
91.28
24%
-83
- C4 -
2O1X
1
DXS_DEIRA
A:
[321-623]
-----------------
A
Y
S
W
S
A
A
F
G
E
A
V
T
E
-
W
A
K
T
D
P
R
T
F
V
V
T
P
A
M
R
-
E
G
S
G
-----
L
-----------
V
E
F
S
R
V
H
-
P
H
-------------
R
Y
L
D
V
G
I
A
E
E
V
A
V
T
T
A
A
G
M
A
L
Q
--
G
--
M
R
-
P
V
V
A
---
I
Y
S
T
F
L
-
Q
R
A
Y
D
Q
V
L
H
D
V
A
I
E
-
H
L
N
V
------
T
F
C
I
D
R
A
G
I
V
-
G
A
D
G
A
T
H
N
G
V
F
D
L
S
F
L
R
S
I
P
G
V
R
I
G
L
P
K
D
A
A
E
L
R
G
M
L
K
Y
A
Q
T
-
H
-
D
G
P
F
A
I
R
Y
P
R
G
N
------
T
A
Q
V
-
P
-
A
G
T
W
--
P
D
L
K
--
W
G
--
E
W
E
-
R
-
L
K
----
G
G
D
--
D
--
V
V
I
L
A
G
G
K
A
L
D
Y
A
L
K
A
A
E
D
L
P
----
G
V
G
V
V
N
A
-----
R
F
V
K
P
L
D
E
E
-----
M
--
L
R
E
-
V
---
G
G
R
-
A
--
R
A
------
L
I
T
V
E
D
N
T
V
V
G
G
F
G
G
A
V
L
E
A
L
-
N
S
M
N
L
H
P
T
V
R
V
L
G
I
P
D
E
F
Q
E
H
A
T
A
E
S
V
H
A
R
A
G
I
D
A
P
A
I
R
T
V
L
A
E
L
G
V
D
--------------
36
HHSearch
89.53
25%
-82
- C4 -
1GPU
1
TKT1_YEAST
A:
[356-665]
------------------
V
A
T
R
K
L
S
E
T
V
L
E
D
-
V
Y
N
Q
L
P
E
L
I
G
G
S
A
D
L
T
-
P
S
N
L
-----
T
RWKEALDFQPP
S
S
G
S
G
N
Y
-
S
G
-------------
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
--
G
AN
Y
K
-
P
Y
G
G
---
T
F
L
N
F
V
-
S
Y
A
A
G
A
V
R
L
S
-
A
L
S
-
G
H
P
V
------
I
W
V
A
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
T
L
A
H
F
R
S
L
P
N
I
Q
V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
L
E
-
S
K
H
T
P
S
I
I
A
L
S
R
Q
N
------
L
P
Q
L
-
E
G
S
-
S
I
--
E
S
A
S
--
K
G
--
G
-
Y
-
V
-
L
Q
D
V
--
A
N
P
--
D
--
I
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
V
V
S
L
-----
P
D
F
F
T
F
D
K
Q
-----
P
--
L
E
Y
-
R
L
S
V
L
PD-
N
--
V
P
------
I
M
S
V
E
V
L
A
-
T
T
C
W
G
K
-------------
Y
A
H
Q
S
F
G
I
-
D
R
F
G
A
S
G
K
A
P
E
V
F
K
F
F
G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
--------------
8
PsiBlast_PDB
88.38
30%
-90
- C4 -
2O1X
1
DXS_DEIRA
A:
[365-594]
---------------------------------------------------------------------------------------------
R
Y
L
D
V
G
I
A
E
E
V
A
V
T
T
A
A
G
M
A
L
Q
--
G
--
M
R
-
P
V
V
A
---
I
Y
S
T
F
L
-
Q
R
A
Y
D
Q
V
L
H
D
V
A
I
E
-
H
L
N
V
------
T
F
C
I
D
R
A
G
I
V
G
-
A
D
G
A
T
H
N
G
V
F
D
L
S
F
L
R
S
I
P
G
V
R
I
G
L
P
K
D
A
A
E
L
R
G
M
L
K
Y
A
Q
T
-
H
-
D
G
P
F
A
I
R
Y
P
R
G
N
------
T
A
Q
V
-
P
-
A
-
G
T
W
-
P
D
L
K
--
W
G
E
-
W
-
E
-
R
-
L
K
----
G
G
D
--
D
--
V
V
I
L
A
G
G
K
A
L
D
Y
A
L
K
A
A
E
D
L
P
G
V
G
----
V
V
N
A
-----
R
F
V
K
P
L
D
E
E
-----
M
--
L
R
E
-
V
---
G
---
G
R
A
R
A
------
L
I
T
V
E
D
N
T
V
V
G
G
F
G
G
A
V
L
E
A
L
N
S
M
N
L
H
-
P
T
V
R
V
L
G
I
P
D
E
F
Q
E
H
A
T
A
E
S
V
H
A
R
A
G
I
D
A
P
A
I
R
T
V
L
A
E
L
G
V
D
--------------
10
PsiBlast_PDB
86.52
26%
-89
- C4 -
1TRK
1
TKT1_YEAST
A:
[404-661]
-------------------------------------------------------------------------
S
G
N
Y
-
S
G
-------------
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
--
G
AN
Y
K
-
P
Y
G
G
---
T
F
L
N
F
V
S
--------
Y
A
A
G
A
V
-
R
L
S
A
L
S
GHPV
I
W
V
A
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
T
L
A
H
F
R
S
L
P
N
I
Q
V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
L
E
-
S
-
K
H
T
P
S
I
I
A
L
S
R
Q
------
N
L
P
Q
-
L
-
E
-
G
S
S
I
E
S
A
S
--
K
G
GY
V
-
L
-
Q
-
D
V
----
A
N
P
--
D
--
I
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
V
V
S
L
PD
F
F
T
F
D
K
Q
P
L
E
Y
R
-----
L
--
S
V
L
-
P
---
D
---
N
--
V
P
------
I
M
S
V
E
-------
V
L
A
T
T
C
-
W
G
-
K
Y
A
H
Q
-
S
----
F
G
I
D
-
R
F
G
A
S
G
K
A
P
E
V
F
K
F
F
G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
--------------
15
PsiBlast_PDB
86.04
26%
-87
- C4 -
1TKC
1
TKT1_YEAST
A:
[402-659]
-------------------------------------------------------------------------
S
G
N
Y
-
S
G
-------------
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
--
G
AN
Y
K
-
P
Y
G
G
---
T
F
L
N
F
V
S
--------
Y
A
A
G
A
V
-
R
L
S
A
L
S
GHPV
I
W
V
A
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
T
L
A
H
F
R
S
L
P
N
I
Q
V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
L
E
-
S
-
K
H
T
P
S
I
I
A
L
S
R
Q
------
N
L
P
Q
-
L
-
E
-
G
S
S
I
E
S
A
S
--
K
G
GY
V
-
L
-
Q
-
D
V
----
A
N
P
--
D
--
I
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
V
V
S
L
PD
F
F
T
F
D
K
Q
P
L
E
Y
R
-----
L
--
S
V
L
-
P
---
D
---
N
--
V
P
------
I
M
S
V
E
-------
V
L
A
T
T
C
-
W
G
-
K
Y
A
H
Q
-
S
----
F
G
I
D
-
R
F
G
A
S
G
K
A
P
E
V
F
K
F
F
G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
--------------
11
PsiBlast_PDB
85.89
26%
-85
- C4 -
1NGS
2
TKT1_YEAST
A:
[404-661]
-------------------------------------------------------------------------
S
G
N
Y
-
S
G
-------------
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
--
G
AN
Y
K
-
P
Y
G
G
---
T
F
L
N
F
V
S
--------
Y
A
A
G
A
V
-
R
L
S
A
L
S
GHPV
I
W
V
A
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
T
L
A
H
F
R
S
L
P
N
I
Q
V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
L
E
-
S
-
K
H
T
P
S
I
I
A
L
S
R
Q
------
N
L
P
Q
-
L
-
E
-
G
S
S
I
E
S
A
S
--
K
G
GY
V
-
L
-
Q
-
D
V
----
A
N
P
--
D
--
I
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
V
V
S
L
PD
F
F
T
F
D
K
Q
P
L
E
Y
R
-----
L
--
S
V
L
-
P
---
D
---
N
--
V
P
------
I
M
S
V
E
-------
V
L
A
T
T
C
-
W
G
-
K
Y
A
H
Q
-
S
----
F
G
I
D
-
R
F
G
A
S
G
K
A
P
E
V
F
K
F
F
G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
--------------
16
PsiBlast_PDB
85.57
26%
-86
- C4 -
1AY0
1
TKT1_YEAST
A:
[404-661]
-------------------------------------------------------------------------
S
G
N
Y
-
S
G
-------------
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
--
G
AN
Y
K
-
P
Y
G
G
---
T
F
L
N
F
V
S
--------
Y
A
A
G
A
V
-
R
L
S
A
L
S
GHPV
I
W
V
A
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
T
L
A
H
F
R
S
L
P
N
I
Q
V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
L
E
-
S
-
K
H
T
P
S
I
I
A
L
S
R
Q
------
N
L
P
Q
-
L
-
E
-
G
S
S
I
E
S
A
S
--
K
G
GY
V
-
L
-
Q
-
D
V
----
A
N
P
--
D
--
I
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
V
V
S
L
PD
F
F
T
F
D
K
Q
P
L
E
Y
R
-----
L
--
S
V
L
-
P
---
D
---
N
--
V
P
------
I
M
S
V
E
-------
V
L
A
T
T
C
-
W
G
-
K
Y
A
H
Q
-
S
----
F
G
I
D
-
R
F
G
A
S
G
K
A
P
E
V
F
K
F
F
G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
--------------
12
PsiBlast_PDB
85.04
26%
-87
- C4 -
1GPU
1
TKT1_YEAST
A:
[404-661]
-------------------------------------------------------------------------
S
G
N
Y
-
S
G
-------------
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
--
G
AN
Y
K
-
P
Y
G
G
---
T
F
L
N
F
V
S
--------
Y
A
A
G
A
V
-
R
L
S
A
L
S
GHPV
I
W
V
A
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
T
L
A
H
F
R
S
L
P
N
I
Q
V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
L
E
-
S
-
K
H
T
P
S
I
I
A
L
S
R
Q
------
N
L
P
Q
-
L
-
E
-
G
S
S
I
E
S
A
S
--
K
G
GY
V
-
L
-
Q
-
D
V
----
A
N
P
--
D
--
I
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
V
V
S
L
PD
F
F
T
F
D
K
Q
P
L
E
Y
R
-----
L
--
S
V
L
-
P
---
D
---
N
--
V
P
------
I
M
S
V
E
-------
V
L
A
T
T
C
-
W
G
-
K
Y
A
H
Q
-
S
----
F
G
I
D
-
R
F
G
A
S
G
K
A
P
E
V
F
K
F
F
G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
--------------
13
PsiBlast_PDB
85.02
26%
-85
- C4 -
1TKA
1
TKT1_YEAST
A:
[402-659]
-------------------------------------------------------------------------
S
G
N
Y
-
S
G
-------------
R
Y
I
R
Y
G
I
R
E
H
A
M
G
A
I
M
N
G
I
S
A
F
--
G
AN
Y
K
-
P
Y
G
G
---
T
F
L
N
F
V
S
--------
Y
A
A
G
A
V
-
R
L
S
A
L
S
GHPV
I
W
V
A
T
H
D
S
I
G
V
G
E
D
G
P
T
H
Q
P
I
E
T
L
A
H
F
R
S
L
P
N
I
Q
V
W
R
P
A
D
G
N
E
V
S
A
A
Y
K
N
S
L
E
-
S
-
K
H
T
P
S
I
I
A
L
S
R
Q
------
N
L
P
Q
-
L
-
E
-
G
S
S
I
E
S
A
S
--
K
G
GY
V
-
L
-
Q
-
D
V
----
A
N
P
--
D
--
I
I
L
V
A
T
G
S
E
V
S
L
S
V
E
A
A
K
T
L
A
A
K
N
I
K
A
R
V
V
S
L
PD
F
F
T
F
D
K
Q
P
L
E
Y
R
-----
L
--
S
V
L
-
P
---
D
---
N
--
V
P
------
I
M
S
V
E
-------
V
L
A
T
T
C
-
W
G
-
K
Y
A
H
Q
-
S
----
F
G
I
D
-
R
F
G
A
S
G
K
A
P
E
V
F
K
F
F
G
F
T
P
E
G
V
A
E
R
A
Q
K
T
I
A
F
--------------
37
HHSearch
84.85
20%
-83
- C4 -
1ITZ
1
TKTC_MAIZE
A:
[366-675]
------------------
D
A
T
R
N
L
S
Q
Q
C
L
N
A
-
L
A
N
V
V
P
G
L
I
G
G
S
A
D
L
A
-
S
S
N
M
TLLKM
F
-----------
G
D
F
Q
K
D
T
A
E
E
-------------
R
N
V
R
F
G
V
R
E
H
G
M
G
A
I
C
N
G
I
A
L
H
SP
G
--
F
V
-
P
Y
C
A
---
T
F
F
V
F
T
-
D
Y
M
R
G
A
M
R
I
S
-
A
L
S
-
E
A
G
V
------
I
Y
V
M
T
H
D
S
I
G
L
G
E
D
G
P
T
H
Q
P
I
E
H
L
V
S
F
R
A
M
P
N
I
L
M
L
R
P
A
D
G
N
E
T
A
G
A
Y
K
V
A
V
L
N
R
-
K
R
P
S
I
L
A
L
S
R
Q
K
------
L
P
H
L
-
P
-
G
T
S
I
--
E
G
V
E
--
K
G
--
G
-
Y
T
I
-
S
D
NSTG
N
K
P
--
D
--
L
I
V
M
G
T
G
S
E
L
E
I
A
A
K
A
A
D
E
L
R
K
E
G
K
T
V
R
V
V
S
F
-----
V
S
W
E
L
F
D
E
Q
-----
S
D
E
Y
K
E
S
V
---
L
PAA
V
--
T
A
------
R
I
S
I
E
A
G
S
T
L
-
G
W
----
Q
K
Y
V
-
G
A
-----
Q
G
K
A
I
G
I
-
D
K
F
G
A
S
A
P
A
G
T
I
Y
K
E
Y
G
I
T
V
E
S
I
I
A
A
A
K
S
F
-----------------