@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0198: (2015-11-29 )
MSKQVFEMIFAGKKLVVETGQVAKQANGSVVVRYGDSTVLTAAVMSKKMSTGDFFPLQVNYEEKMYAAGKFPGGFNKREGRPSTDATLTARLIDRPIRPMFAEGFRNEVQVINTVLSFDENASAPMAAMFGSSLALSISDIPFNGPIAGVQVAYVDGNFIINPTAQEQEASALELTVAGTKEAINMVESGAKELSEEIMLEALLKGHEAVCELIAFQEEIVTAIGKEKAEVELLQVDPELQAEIIATHNIALQAAVQVEEKKAREAATEAVKEVVIGEYEARYAEHEEYDRIMRDVAEILEQMEHAEVRRLITEDKVRPDGRRVDEIRPLDAVIDFLPQVHGSGLFTRGQTQALSVLTLAPMGEAQIIDGLTPEYKKRFMHHYNFPQYSVGETGRYGAAGRREIGHGALGERALEQVLPSLEEFPYAIRLVAEVLESNGSSSQASICAGTLALMAGGVPIKAPVAGIAMGLISDGTNYTVLTDIQGLEDHFGDMDFKVAGTREGITALQMDIKIEGITPQILEEALAQAKKARFEILDVLHGAIAEPRPQLAPTAPKIDMIKIDVDKIKVVIGKGGETIDKIIAETGVKIDIDEEGNVSIFSSDQAAIDRTKDIIASLVREAKVGEVYHAKVVRIEKFGAFVNLFDKTDALVHISEIAWTRTANVADVLEIGEEVDVKVIKIDDKGRVDASMKALLPRPPKADNPKKES
Atome Classification :
(30 SA)
.........10-----........20........30.......-.40........50-.--.......60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......-----------------180---.-........190.......------------200.......210.......220...-....230-.-..-....240.......250.....--.-----.260.........270----.......280.......290.......300.......310.......320.......330.......340.......350.......----360...----....370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.---..-------.-------...480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
K
Q
V
F
E
M
I
FA-----G
K
K
L
V
VET
G
Q
V
A
KQAN
G
S
V
V
V
R
YGD
S
T
-
V
L
T
A
A
V
M
S
KKMST-G--
D
F
F
P
L
Q
VNY
E
E
K
M
Y
AAGKFPGGFNKREGRPST
D
A
T
L
T
A
R
L
IDRPI
R
P
M
F
A
E
G
FR
N
E
V
Q
V
I
N
T
V
L
SFDENASA
P
M
A
A
M
FGS
S
L
A
L
S
I
SDIPFNGPIA
G
V
Q
V
A
Y
VDG
N
F
I
INPTAQEQEA
S
A
L
E
L
T
VAG-----------------
T
-----
K
-
E
A
I
N
M
V
E
S
G
A
K
E
L
S
E
E
I
M
------------
L
E
A
L
L
K
G
H
E
A
V
C
E
L
I
A
F
Q
E
E
I
V
T
A
IG-KEK
A
E
V
E
-
L
-
L
Q-VDPEL
Q
A
E
I
I
A
TH
N
I
A
L
Q
A
A
V
Q
--
V
-----
E
E
--
K
K
A
R
E
A
A
T
E
A
V
K
----
E
V
V
I
G
E
Y
E
A
R
Y
A
E
H
E
E
Y
D
R
I
M
R
D
V
A
E
I
L
E
Q
M
E
H
A
E
V
R
R
L
I
T
EDKVRPDGRRVDEIR
P
L
D
A
V
I
D
F
L
P
Q
VHGSGLFTRGQ
T
Q
A
L
S
V
L
T
L----APMGE
A
----
Q
I
IDGL
T
P
E
Y
K
K
R
F
M
H
HYNFPQYSVGETGRYGAAGRREIGH
G
A
L
G
E
R
A
L
E
Q
V
L
P
S
L
E
EF
P
Y
A
I
R
L
V
A
E
V
L
ESNGSSS
Q
A
S
I
C
A
G
T
L
A
L
MAGGVPIKA
P
V
A
G
I
A
M
G
L
IS---DG-------T-------
N
Y
T
V
L
T
DIQ
G
L
E
D
HFGDM
D
F
K
V
AGTREG
I
T
A
L
Q
M
D
I
K
I
EGI
T
P
Q
I
L
E
E
A
L
A
Q
A
K
K
A
R
F
E
I
L
D
V
L
H
G
A
IAEPRPQLAPTAP
K
I
D
M
I
K
I
DV
D
K
I
K
V
V
IGKGG
E
T
I
D
K
I
I
A
ETG
V
K
I
D
IDEEG
N
V
S
I
FSS
D
Q
A
A
I
D
R
T
K
D
I
I
A
S
L
V
R
EAKVG
E
V
Y
H
A
K
V
V
R
I
E
K
F
G
A
F
V
N
L
FDKTD
A
L
V
H
I
S
E
I
A
WTRTA
N
V
A
D
V
L
EIGEEV
D
V
K
V
I
K
IDDKGRV
D
A
S
M
K
A
LLPRPPKADNPKKES
3
PsiBlast_PDB
88.70
47%
-85
- C3 -
4AIM
2
PNP_CAUCR
A:
[25-708]
---------
W
G
-----
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
-
V
L
A
T
A
V
F
A
K
S
Q
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-----------------
T
-----
A
-
D
A
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
------------
L
G
G
V
N
F
A
H
Q
Q
M
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
-
K
E
P
F
A
F
E
-
P
-
E
D
-
T
D
A
-
I
K
A
K
M
K
D
L
V
G
A
D
I
A
A
A
Y
K
--
I
-----
Q
K
--
K
Q
D
R
Y
E
A
V
G
A
A
K
----
K
K
A
I
A
A
L
G
L
S
D
E
N
P
T
G
Y
D
P
L
--
K
L
G
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
----
G
T
G
D
D
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
---
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
K
I
E
T
I
N
I
P
T
D
K
I
R
E
V
I
G
S
G
G
K
V
I
R
E
I
V
A
T
T
G
A
K
V
D
I
N
D
D
G
V
V
K
V
S
A
S
D
G
A
K
I
K
A
A
I
D
W
I
K
S
I
T
D
E
A
E
I
G
K
I
Y
D
G
K
V
V
K
V
V
D
F
G
A
F
V
N
F
F
G
A
K
D
G
L
V
H
V
S
Q
I
S
N
E
R
V
A
K
P
S
D
V
L
K
E
G
Q
M
V
K
V
K
L
L
G
F
D
D
R
G
K
T
K
L
S
M
K
V
V
D
Q
------------
69
Fugue
86.30
43%
-70
- C3 -
1E3P
6
PNP_STRAT
A:
[20-734]
N
E
T
H
Y
A
E
A
V
I
D
NGAF
G
T
R
T
I
R
F
E
T
G
R
L
A
R
Q
A
A
G
S
A
V
A
Y
L
D
D
D
T
-
M
V
L
S
A
T
T
A
S
K
N
P
K
-
D
QL
D
F
F
P
L
T
V
D
V
E
E
R
M
Y
A
A
G
K
I
P
G
S
F
F
R
R
E
G
R
P
S
E
D
A
I
L
T
C
R
L
I
D
R
P
L
R
P
S
F
K
K
G
L
R
N
E
I
Q
V
V
A
T
I
M
A
L
N
P
D
H
L
Y
D
V
V
A
I
N
A
A
S
A
S
T
Q
L
A
G
L
P
F
S
G
P
I
G
G
V
R
V
A
L
I
R
G
Q
W
V
A
F
P
T
H
T
E
L
E
D
A
V
F
D
M
V
V
A
G
-----------------
R
V
L
EDG
D
-
V
A
I
M
M
V
E
A
E
A
T
E
K
T
I
Q
L
V
K
D
G
A
E
A
PT
E
E
V
V
A
A
G
L
D
A
A
K
P
F
I
K
V
L
C
K
A
Q
A
D
L
A
A
K
A
A
-
K
P
T
G
E
F
P
-
V
F
L
D
-
Y
Q
D
D
V
L
E
A
L
S
A
A
V
R
P
E
L
S
A
A
L
T
--
I
-----
A
G
--
K
Q
D
R
E
A
E
L
D
R
V
K
----
A
L
A
A
E
K
L
L
------
P
E
F
E
G
R
E
K
E
I
S
A
A
Y
R
A
L
T
K
S
L
V
R
E
R
V
I
A
E
K
K
R
I
D
G
R
G
V
T
D
I
R
T
L
A
A
E
V
E
A
I
P
R
V
H
G
S
A
L
F
E
R
G
E
T
Q
I
L
G
V
T
T
L
----
N
M
L
R
M
E
----
Q
Q
L
D
T
L
S
P
V
T
R
K
R
Y
M
H
N
Y
N
F
P
P
Y
S
V
G
E
T
G
R
V
G
S
P
K
R
R
E
I
G
H
G
A
L
A
E
R
A
I
V
P
V
L
P
T
R
E
E
F
P
Y
A
I
R
Q
V
S
E
A
L
G
S
N
G
S
T
S
M
G
S
V
C
A
S
T
M
S
L
L
N
A
G
V
P
L
K
A
P
V
A
G
I
A
M
G
L
I
S
---
Q
E
ING
E
---
T
-------
H
Y
V
A
L
T
D
I
L
G
A
E
D
A
F
G
D
M
D
F
K
V
A
G
T
K
E
F
V
T
A
L
Q
L
D
T
K
L
D
G
I
P
A
S
V
L
A
A
A
L
K
Q
A
R
D
A
R
L
H
I
L
D
V
M
M
E
A
I
D
T
P
D
E
-
M
S
P
N
A
P
R
I
------------------
I
T
V
N
Q
I
Q
E
D
T
G
A
E
I
Y
I
G
--------
A
A
D
G
P
A
A
E
A
G
S
--------------------
V
V
K
T
T
F
G
A
F
V
S
L
L
D
---
G
L
L
H
L
G
V
---------------
G
Q
K
V
Q
V
E
I
A
E
I
D
S
R
G
K
----------------------
1
PsiBlast_PDB
85.83
48%
-81
- C3 -
4AM3
5
PNP_CAUCR
A:
[16-625]
---------
W
G
-----
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
-
V
L
A
T
A
V
F
A
K
S
Q
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-----------------
T
-----
A
-
D
A
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
------------
L
G
G
V
N
F
A
H
Q
Q
M
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
-
K
E
P
F
A
F
E
-
P
-
E
D
-
T
D
A
-
I
K
A
K
M
K
D
L
V
G
A
D
I
A
A
A
Y
K
--
I
-----
Q
K
--
K
Q
D
R
Y
E
A
V
G
A
A
K
----
K
K
A
I
A
A
L
G
L
S
D
E
N
P
T
G
Y
D
P
L
--
K
L
G
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
----
G
T
G
D
D
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
---
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
K
I
E
T
I
N
I
P
T
D
K
I
R
E
V
I
G
S
G
G
K
V
I
R
E
I
V
A
T
T
G
A
K
V
D
I
N
D
D
G
V
V
K
V
S
A
S
D
G
A
K
I
K
A
A
I
D
W
I
K
S
I
T
D
E
----------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.27
48%
-80
- C3 -
4AM3
5
PNP_CAUCR
C:
[16-624]
---------
W
G
-----
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
-
V
L
A
T
A
V
F
A
K
S
Q
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-----------------
T
-----
A
-
D
A
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
------------
L
G
G
V
N
F
A
H
Q
Q
M
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
-
K
E
P
F
A
F
E
-
P
-
E
D
-
T
D
A
-
I
K
A
K
M
K
D
L
V
G
A
D
I
A
A
A
Y
K
--
I
-----
Q
K
--
K
Q
D
R
Y
E
A
V
G
A
A
K
----
K
K
A
I
A
A
L
G
L
S
D
E
N
P
T
G
Y
D
P
L
--
K
L
G
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
----
G
T
G
D
D
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
---
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
K
I
E
T
I
N
I
P
T
D
K
I
R
E
V
I
G
S
G
G
K
V
I
R
E
I
V
A
T
T
G
A
K
V
D
I
N
D
D
G
V
V
K
V
S
A
S
D
G
A
K
I
K
A
A
I
D
W
I
K
S
I
T
D
-----------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.27
48%
-84
- C3 -
4AM3
5
PNP_CAUCR
B:
[16-624]
---------
W
G
-----
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
-
V
L
A
T
A
V
F
A
K
S
Q
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-----------------
T
-----
A
-
D
A
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
------------
L
G
G
V
N
F
A
H
Q
Q
M
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
-
K
E
P
F
A
F
E
-
P
-
E
D
-
T
D
A
-
I
K
A
K
M
K
D
L
V
G
A
D
I
A
A
A
Y
K
--
I
-----
Q
K
--
K
Q
D
R
Y
E
A
V
G
A
A
K
----
K
K
A
I
A
A
L
G
L
S
D
E
N
P
T
G
Y
D
P
L
--
K
L
G
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
----
G
T
G
D
D
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
---
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
K
I
E
T
I
N
I
P
T
D
K
I
R
E
V
I
G
S
G
G
K
V
I
R
E
I
V
A
T
T
G
A
K
V
D
I
N
D
D
G
V
V
K
V
S
A
S
D
G
A
K
I
K
A
A
I
D
W
I
K
S
I
T
D
-----------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.36
48%
-80
- C3 -
4AID
2
PNP_CAUCR
A:
[25-627]
---------
W
G
-----
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
-
V
L
A
T
A
V
F
A
K
S
Q
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-----------------
T
-----
A
-
D
A
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
------------
L
G
G
V
N
F
A
H
Q
Q
M
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
-
K
E
P
F
A
F
E
-
P
-
E
D
-
T
D
A
-
I
K
A
K
M
K
D
L
V
G
A
D
I
A
A
A
Y
K
--
I
-----
Q
K
--
K
Q
D
R
Y
E
A
V
G
A
A
K
----
K
K
A
I
A
A
L
G
L
S
D
E
N
P
T
G
Y
D
P
L
--
K
L
G
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
----
G
T
G
D
D
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
---
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
K
-------------------------------------------
S
A
S
D
G
A
K
I
K
A
A
I
D
W
-----------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.66
42%
-78
- C3 -
1E3H
9
PNP_STRAT
A:
[34-649]
---------
F
G
-----
T
R
T
I
R
F
E
T
G
R
L
A
R
Q
A
A
G
S
A
V
A
Y
L
D
D
D
T
M
V
L
S
A
T
T
A
S
K
N
P
K
D
-
Q
L-
D
F
F
P
L
T
V
D
V
E
E
R
M
Y
A
A
G
K
I
P
G
S
F
F
R
R
E
G
R
P
S
E
D
A
I
L
T
C
R
L
I
D
R
P
L
R
P
S
F
K
K
G
L
R
N
E
I
Q
V
V
A
T
I
M
A
L
N
P
D
H
L
Y
D
V
V
A
I
N
A
A
S
A
S
T
Q
L
A
G
L
P
F
S
G
P
I
G
G
V
R
V
A
L
I
R
G
Q
W
V
A
F
P
T
H
T
E
L
E
D
A
V
F
D
M
V
V
A
G
R
V
L
EDG
D
V
A
I
M
M
V
E
A
E
A
T
-----
E
-
K
T
I
Q
L
V
K
D
G
A
E
A
P
T
E
E
V
V
------------
A
A
G
L
D
A
A
K
P
F
I
K
V
L
C
K
A
Q
A
D
L
A
A
K
A
A
-
K
P
T
G
E
F
P
V
F
-
L
D
-
Y
Q
D
D
V
L
E
A
L
S
A
A
V
R
P
E
L
S
A
A
L
T
--
I
-----
A
G
--
K
Q
D
R
E
A
E
L
D
R
V
K
A
L
A
A
E
K
L
L
P
E
F
E
G
R
E
K
E
----------
I
S
A
A
Y
R
A
L
T
K
S
L
V
R
E
R
V
I
A
E
K
K
R
I
D
G
R
G
V
T
D
I
R
T
L
A
A
E
V
E
A
I
P
R
V
H
G
S
A
L
F
E
R
G
E
T
Q
I
L
G
V
T
T
L
----
N
M
L
R
M
E
----
Q
Q
L
D
T
L
S
P
V
T
R
K
R
Y
M
H
N
Y
N
F
P
P
Y
S
V
G
E
T
G
R
V
G
S
P
K
R
R
E
I
G
H
G
A
L
A
E
R
A
I
V
P
V
L
P
T
R
E
E
F
P
Y
A
I
R
Q
V
S
E
A
L
G
S
N
G
S
T
S
M
G
S
V
C
A
S
T
M
S
L
L
N
A
G
V
P
L
K
A
P
V
A
G
I
A
M
G
L
I
S
Q
EI
N
G
E
------
T
-------
H
Y
V
A
L
T
D
I
L
G
A
E
D
A
F
G
D
M
D
F
K
V
A
G
T
K
E
F
V
T
A
L
Q
L
D
T
K
L
D
G
I
P
A
S
V
L
A
A
A
L
K
Q
A
R
D
A
R
L
H
I
L
D
V
M
M
E
A
I
D
T
P
D
-
E
M
S
P
N
A
P
R
I
I
---------------------
Q
I
Q
E
D
T
G
A
E
I
--------
Y
I
G
A
A
D
G
P
A
A
-----------------------------------------------------------------------------------------------------
79
HHSearch
81.29
47%
-89
- C3 -
3CDI
-
PNP_ECOLI
A:
[25-565]
L
N
P
I
V
R
K
F
Q
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
G
Q
--
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
-------
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
L
A
E
D
-----
E
T
L
D
E
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
-----------------
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
-----
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Fugue
81.16
37%
-82
- C3 -
3U1K
2
PNPT1_HUMAN
A:
[4-627]
-
M
A
S
A
V
A
V
D
L
G
-----
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
D
G
S
A
V
V
Q
S
G
D
T
A
-
V
M
V
T
A
V
S
K
T
K
P
S
P
-
S
--
Q
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
G
R
I
P
T
N
Y
L
T
-----
S
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
Y
F
Y
D
T
Q
V
L
C
N
L
L
A
V
D
G
V
N
E
P
D
V
L
A
I
N
G
A
S
V
A
L
S
L
S
D
I
P
W
N
G
P
V
G
A
V
R
I
G
I
I
D
G
E
Y
V
V
N
P
T
R
K
E
M
S
S
S
T
L
N
L
V
V
A
G
-----------------
A
P
----
K
-
S
Q
I
V
M
L
E
A
S
A
E
N
I
L
Q
Q
D
F
------------
C
H
A
I
K
V
G
V
K
Y
T
Q
Q
I
I
Q
G
I
Q
Q
L
V
K
E
T
G
-
V
T
K
R
T
P
Q
K
L
-
F
T
-
P
S
P
E
I
V
K
Y
T
H
K
L
A
M
E
R
L
Y
A
V
F
T
--
D
-----
Y
E
HD
K
V
S
R
D
E
A
V
N
K
I
R
----
L
D
T
E
E
Q
L
K
E
K
F
P
E
A
D
-----
P
Y
E
I
I
E
S
F
N
V
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
T
L
H
G
S
A
L
F
Q
R
G
Q
T
Q
V
L
C
T
V
T
F
D
S
L
E
S
G
I
K
S
D
----
Q
V
I
T
A
I
N
G
I
K
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
V
T
G
L
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
Y
P
V
I
P
--
R
D
F
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
S
L
A
L
M
D
S
G
V
P
I
S
S
A
V
A
G
V
A
I
G
L
V
T
---
K
T
D
PEKGEI
E
-------
D
Y
R
L
L
T
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
I
A
G
T
N
K
G
I
T
A
L
Q
A
D
I
K
L
P
G
I
P
I
K
I
V
M
E
A
I
Q
Q
A
S
V
A
K
K
E
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
A
M
H
E
A
R
D
F
I
T
E
--------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.15
48%
-89
- C3 -
3CDI
-
PNP_ECOLI
A:
[34-565]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
-------
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
-----------------
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
-----
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
80.99
49%
-80
- C3 -
3GCM
7
PNP_ECOLI
C:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
E
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.73
46%
-74
- C3 -
4NBQ
3
PNP_COXBU
C:
[29-638]
---------
Y
G
-----
K
H
E
V
T
F
E
T
G
E
-
A
R
Q
A
T
G
A
V
V
V
R
-
G
D
T
V
-
L
L
V
S
V
V
A
K
K
E
A
E
---R-
D
F
F
P
L
T
V
N
Y
Q
E
K
T
Y
A
A
G
K
I
P
G
G
Y
F
K
R
E
G
R
P
T
E
K
E
T
L
T
S
R
L
I
D
R
P
L
R
P
L
F
P
K
G
F
T
N
E
V
Q
V
I
A
T
V
L
S
V
D
S
K
V
P
T
D
I
P
A
I
L
G
A
S
A
A
I
G
L
S
G
I
P
F
N
G
S
L
G
A
A
R
V
G
Y
R
G
G
E
Y
L
L
N
P
S
L
D
E
L
K
D
S
A
L
D
L
V
V
A
G
-----------------
T
-----
R
-
D
A
V
-
L
V
E
S
E
A
Q
E
L
P
E
S
V
-------------
L
G
A
V
L
H
G
H
Q
A
Q
V
A
I
Q
A
I
A
E
F
I
Q
E
A
-
G
-
G
A
K
W
E
W
E
-
P
-
P
T
-
V
N
T
A
L
E
K
W
V
V
E
K
S
E
A
P
L
K
K
A
Y
Q
--
I
-----
Q
E
--
K
T
A
R
Q
A
Q
I
Q
A
I
R
----
D
Q
L
L
A
D
R
A
A
E
----------
E
H
E
L
A
V
I
F
H
E
L
E
R
R
I
V
R
E
Q
I
L
T
G
Q
P
R
I
D
G
R
D
T
K
T
V
R
P
I
T
V
K
V
G
V
L
P
R
S
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
V
T
T
L
----
G
T
E
R
D
A
----
Q
S
I
D
D
L
D
G
D
R
Q
E
E
F
I
F
H
Y
N
F
P
P
F
C
V
G
E
V
G
-
F
-
G
P
K
R
R
E
I
G
H
G
R
L
A
K
R
A
V
V
P
V
V
P
T
L
D
K
F
P
Y
V
I
R
V
V
S
E
I
L
E
S
N
G
S
S
S
A
S
V
C
G
S
-
S
L
A
L
D
A
-
G
V
P
T
K
A
P
V
A
G
I
A
-
G
L
I
K
---
E
N
-------
D
-------
K
Y
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
-
D
F
K
V
A
G
T
S
N
G
V
T
A
L
Q
-
D
I
K
I
E
G
I
T
K
E
I
-
E
Q
A
L
D
Q
A
K
E
G
R
L
H
I
L
S
I
-
N
K
V
L
D
K
P
R
S
Q
V
S
D
L
A
P
Q
Y
-
V
T
K
I
N
P
E
K
I
R
D
V
I
G
K
G
G
V
V
I
R
E
I
T
E
A
T
N
C
A
I
D
I
S
D
D
G
T
I
K
I
A
A
H
T
T
E
E
G
E
A
A
K
R
R
I
E
E
L
T
------------------------------------------------------------------------------------------
81
HHSearch
80.55
37%
-82
- C3 -
3U1K
2
PNPT1_HUMAN
A:
[6-627]
---
S
A
V
A
V
D
L
G
-----
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
D
G
S
A
V
V
Q
S
G
D
T
A
-
V
M
V
T
A
V
S
K
T
K
P
S
P
-
S
--
Q
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
G
R
I
P
T
N
Y
L
-----
T
S
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
Y
F
Y
D
T
Q
V
L
C
N
L
L
A
V
D
G
V
N
E
P
D
V
L
A
I
N
G
A
S
V
A
L
S
L
S
D
I
P
W
N
G
P
V
G
A
V
R
I
G
I
I
D
G
E
Y
V
V
N
P
T
R
K
E
M
S
S
S
T
L
N
L
V
V
A
G
-----------------
A
-----
P
K
S
Q
I
V
M
L
E
A
S
A
E
N
I
L
Q
Q
D
F
------------
C
H
A
I
K
V
G
V
K
Y
T
Q
Q
I
I
Q
G
I
Q
Q
L
V
K
E
T
G
-
V
T
K
R
T
P
Q
-
K
-
L
F
T
P
S
P
E
I
V
K
Y
T
H
K
L
A
M
E
R
L
Y
A
V
F
T
DY
E
-----
H
D
--
K
V
S
R
D
E
A
V
N
K
I
R
----
L
D
T
E
E
Q
L
K
E
K
F
-----
P
E
A
D
P
Y
E
I
I
E
S
F
N
V
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
T
L
H
G
S
A
L
F
Q
R
G
Q
T
Q
V
L
C
T
V
T
F
----
D
S
L
E
S
G
I
KSD
Q
V
I
T
A
I
N
G
I
K
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
V
T
G
L
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
Y
P
V
I
P
R
--
D
F
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
S
L
A
L
M
D
S
G
V
P
I
S
S
A
V
A
G
V
A
I
G
L
V
T
---
K
T
D
PEKGEI
E
-------
D
Y
R
L
L
T
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
I
A
G
T
N
K
G
I
T
A
L
Q
A
D
I
K
L
P
G
I
P
I
K
I
V
M
E
A
I
Q
Q
A
S
V
A
K
K
E
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
A
M
H
E
A
R
D
F
I
T
E
--------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.46
36%
-81
- C3 -
3U1K
2
PNPT1_HUMAN
A:
[12-627]
---------
L
G
-----
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
D
G
S
A
V
V
Q
S
G
D
T
A
-
V
M
V
T
A
V
S
K
T
K
P
S
P
-
S
--
Q
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
G
R
I
P
T
N
Y
L
-----
T
S
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
Y
F
Y
D
T
Q
V
L
C
N
L
L
A
V
D
G
V
N
E
P
D
V
L
A
I
N
G
A
S
V
A
L
S
L
S
D
I
P
W
N
G
P
V
G
A
V
R
I
G
I
I
D
G
E
Y
V
V
N
P
T
R
K
E
M
S
S
S
T
L
N
L
V
V
A
G
-----------------
A
P
----
K
-
S
Q
I
V
M
L
E
A
S
A
E
N
I
L
Q
Q
D
F
------------
C
H
A
I
K
V
G
V
K
Y
T
Q
Q
I
I
Q
G
I
Q
Q
L
V
K
E
T
G
V
T
K
R
T
P
Q
K
-
L
-
F
T
-
P
S
P
E
I
---
V
K
Y
T
H
K
L
A
M
E
R
L
Y
A
--
V
F
T
DYE
H
D
--
K
V
S
R
D
E
A
V
N
K
I
R
----
L
D
T
E
E
Q
L
K
E
K
F
P
E
A
D
P
Y
-----
E
I
I
E
S
F
N
V
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
T
L
H
G
S
A
L
F
Q
R
G
Q
T
Q
V
L
C
T
V
T
F
----
D
S
L
E
S
G
I
KSD
Q
V
I
T
A
I
N
G
I
K
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
V
T
G
L
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
Y
P
V
I
P
--
R
D
F
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
S
L
A
L
M
D
S
G
V
P
I
S
S
A
V
A
G
V
A
I
G
L
V
T
---
K
T
-------
D
PEKGEIE
D
Y
R
L
L
T
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
I
A
G
T
N
K
G
I
T
A
L
Q
A
D
I
K
L
P
G
I
P
I
K
I
V
M
E
A
I
Q
Q
A
S
V
A
K
K
E
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
A
M
H
E
A
R
D
F
I
T
E
--------------------------------------------------------------------------------------------
39
PsiBlast_CBE
80.44
36%
-82
- C3 -
3U1K
2
PNPT1_HUMAN
D:
[12-629]
---------
L
G
-----
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
D
G
S
A
V
V
Q
S
G
D
T
A
-
V
M
V
T
A
V
S
K
T
K
P
S
P
-
S
--
Q
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
G
R
I
P
T
N
Y
L
-----
T
S
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
Y
F
Y
D
T
Q
V
L
C
N
L
L
A
V
D
G
V
N
E
P
D
V
L
A
I
N
G
A
S
V
A
L
S
L
S
D
I
P
W
N
G
P
V
G
A
V
R
I
G
I
I
D
G
E
Y
V
V
N
P
T
R
K
E
M
S
S
S
T
L
N
L
V
V
A
G
-----------------
A
P
----
K
-
S
Q
I
V
M
L
E
A
S
A
E
N
I
L
Q
Q
D
F
------------
C
H
A
I
K
V
G
V
K
Y
T
Q
Q
I
I
Q
G
I
Q
Q
L
V
K
E
T
G
V
T
K
R
T
P
Q
K
-
L
-
F
T
-
P
S
P
E
I
---
V
K
Y
T
H
K
L
A
M
E
R
L
Y
A
--
V
F
T
DYE
H
D
--
K
V
S
R
D
E
A
V
N
K
I
R
----
L
D
T
E
E
Q
L
K
E
K
F
P
E
A
D
P
Y
-----
E
I
I
E
S
F
N
V
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
T
L
H
G
S
A
L
F
Q
R
G
Q
T
Q
V
L
C
T
V
T
F
----
D
S
L
E
S
G
I
KSD
Q
V
I
T
A
I
N
G
I
K
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
V
T
-
L
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
Y
P
V
I
P
--
R
D
F
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
S
L
A
L
M
D
S
G
V
P
I
S
S
A
V
A
G
V
A
I
G
L
V
T
---
K
T
--------IE-----
D
Y
R
L
L
T
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
I
A
G
T
N
K
G
I
T
A
L
Q
A
D
I
K
L
P
G
I
P
I
K
I
V
M
E
A
I
Q
Q
A
S
V
A
K
K
E
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
A
M
H
E
A
R
D
F
I
T
E
I
C
------------------------------------------------------------------------------------------
40
PsiBlast_CBE
80.41
36%
-82
- C3 -
3U1K
2
PNPT1_HUMAN
C:
[12-629]
---------
L
G
-----
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
D
G
S
A
V
V
Q
S
G
D
T
A
-
V
M
V
T
A
V
S
K
T
K
P
S
P
-
S
--
Q
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
G
R
I
P
T
N
Y
L
R
---
G
T
S
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
Y
F
Y
D
T
Q
V
L
C
N
L
L
A
V
D
G
V
N
E
P
D
V
L
A
I
N
G
A
S
V
A
L
S
L
S
D
I
P
W
N
G
P
V
G
A
V
R
I
G
I
I
D
G
E
Y
V
V
N
P
T
R
K
E
M
S
S
S
T
L
N
L
V
V
A
G
-----------------
A
P
----
K
-
S
Q
I
V
M
L
E
A
S
A
E
N
I
L
Q
Q
D
F
------------
C
H
A
I
K
V
G
V
K
Y
T
Q
Q
I
I
Q
G
I
Q
Q
L
V
K
E
T
G
V
T
K
R
T
P
Q
K
-
L
-
F
T
-
P
S
P
E
I
---
V
K
Y
T
H
K
L
A
M
E
R
L
Y
A
--
V
F
T
DYE
H
D
--
K
V
S
R
D
E
A
V
N
K
I
R
----
L
D
T
E
E
Q
L
K
E
K
F
P
E
A
D
P
Y
-----
E
I
I
E
S
F
N
V
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
T
L
H
G
S
A
L
F
Q
R
G
Q
T
Q
V
L
C
T
V
T
F
----
D
S
L
E
S
G
I
KSD
Q
V
I
T
A
I
N
G
I
K
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
V
T
G
L
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
Y
P
V
I
P
--
R
D
F
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
S
L
A
L
M
D
S
G
V
P
I
S
S
A
V
A
G
V
A
I
G
L
V
T
---
K
T
-------
D
GEIE---
D
Y
R
L
L
T
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
I
A
G
T
N
K
G
I
T
A
L
Q
A
D
I
K
L
P
G
I
P
I
K
I
V
M
E
A
I
Q
Q
A
S
V
A
K
K
E
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
A
M
H
E
A
R
D
F
I
T
E
I
C
------------------------------------------------------------------------------------------
41
PsiBlast_CBE
80.37
36%
-81
- C3 -
3U1K
2
PNPT1_HUMAN
B:
[12-629]
---------
L
G
-----
N
R
K
L
E
I
S
S
G
K
L
A
R
F
A
D
G
S
A
V
V
Q
S
G
D
T
A
-
V
M
V
T
A
V
S
K
T
K
P
S
P
-
S
--
Q
F
M
P
L
V
V
D
Y
R
Q
K
A
A
A
A
G
R
I
P
T
N
Y
L
----
G
T
S
D
K
E
I
L
T
S
R
I
I
D
R
S
I
R
P
L
F
P
A
G
Y
F
Y
D
T
Q
V
L
C
N
L
L
A
V
D
G
V
N
E
P
D
V
L
A
I
N
G
A
S
V
A
L
S
L
S
D
I
P
W
N
G
P
V
G
A
V
R
I
G
I
I
D
G
E
Y
V
V
N
P
T
R
K
E
M
S
S
S
T
L
N
L
V
V
A
G
-----------------
A
P
----
K
-
S
Q
I
V
M
L
E
A
S
A
E
N
I
L
Q
Q
D
F
------------
C
H
A
I
K
V
G
V
K
Y
T
Q
Q
I
I
Q
G
I
Q
Q
L
V
K
E
T
G
V
T
K
R
T
P
Q
K
-
L
-
F
T
-
P
S
P
E
I
---
V
K
Y
T
H
K
L
A
M
E
R
L
Y
A
--
V
F
T
DYE
H
D
--
K
V
S
R
D
E
A
V
N
K
I
R
----
L
D
T
E
E
Q
L
K
E
K
F
P
E
A
D
P
Y
-----
E
I
I
E
S
F
N
V
V
A
K
E
V
F
R
S
I
V
L
N
E
Y
K
R
C
D
G
R
D
L
T
S
L
R
N
V
S
C
E
V
D
M
F
K
T
L
H
G
S
A
L
F
Q
R
G
Q
T
Q
V
L
C
T
V
T
F
----
D
S
L
E
S
G
I---
Q
V
I
T
A
I
N
G
I
K
D
K
N
F
M
L
H
Y
E
F
P
P
Y
A
T
N
E
I
G
K
V
T
G
L
N
R
R
E
L
G
H
G
A
L
A
E
K
A
L
Y
P
V
I
P
--
R
D
F
P
F
T
I
R
V
T
S
E
V
L
E
S
N
G
S
S
S
M
A
S
A
C
G
G
S
L
A
L
M
D
S
G
V
P
I
S
S
A
V
A
G
V
A
I
G
L
V
T
---
K
T
-------
D
PGEIE--
D
Y
R
L
L
T
D
I
L
G
I
E
D
Y
N
G
D
M
D
F
K
I
A
G
T
N
K
G
I
T
A
L
Q
A
D
I
K
L
P
G
I
P
I
K
I
V
M
E
A
I
Q
Q
A
S
V
A
K
K
E
I
L
Q
I
M
N
K
T
I
S
K
P
R
A
S
R
K
E
N
G
P
V
V
E
T
V
Q
V
P
L
S
K
R
A
K
F
V
G
P
G
G
Y
N
L
K
K
L
Q
A
E
T
G
V
T
I
S
Q
V
D
E
E
T
F
S
V
F
A
P
T
P
S
A
M
H
E
A
R
D
F
I
T
E
I
C
------------------------------------------------------------------------------------------
38
PsiBlast_CBE
80.37
49%
-80
- C3 -
3GCM
9
PNP_ECOLI
B:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
E
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
80.14
48%
-85
- C3 -
4AID
2
PNP_CAUCR
C:
[25-569]
---------
W
G
-----
G
K
T
L
V
L
E
T
G
R
I
A
R
Q
A
D
G
A
V
L
A
T
M
G
E
T
V
-
V
L
A
T
A
V
F
A
K
S
Q
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
K
T
F
A
A
G
K
I
P
G
G
F
F
K
R
E
G
R
P
S
E
K
E
T
L
V
S
R
L
I
D
R
P
I
R
P
L
F
V
K
G
F
K
N
E
V
Q
V
V
V
T
V
L
Q
H
D
L
E
N
D
P
D
I
L
G
M
V
A
A
S
A
A
L
C
L
S
G
A
P
F
M
G
P
I
G
A
A
R
V
G
W
V
D
G
A
Y
V
L
N
P
T
L
D
E
M
K
E
S
K
M
D
L
V
V
A
G
-----------------
T
-----
A
-
D
A
V
M
M
V
E
S
E
I
Q
E
L
S
E
E
I
V
------------
L
G
G
V
N
F
A
H
Q
Q
M
Q
A
V
I
D
A
I
I
D
L
A
E
H
A
A
-
K
E
P
F
A
F
E
-
P
-
E
D
-
T
D
A
-
I
K
A
K
M
K
D
L
V
G
A
D
I
A
A
A
Y
K
--
I
-----
Q
K
--
K
Q
D
R
Y
E
A
V
G
A
A
K
----
K
K
A
I
A
--------------------
A
I
F
K
E
L
E
A
D
V
V
R
R
G
I
L
D
T
G
L
R
I
D
G
R
D
V
K
T
V
R
P
I
L
G
E
V
G
I
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
I
V
V
A
T
L
----
G
T
G
D
D
E
----
Q
F
I
D
A
L
E
G
T
Y
K
E
S
F
L
L
H
Y
N
F
P
P
Y
S
V
G
E
T
G
R
M
G
S
P
G
R
R
E
I
G
H
G
K
L
A
W
R
A
L
R
P
M
L
P
T
K
E
D
F
P
Y
T
I
R
L
V
S
E
I
T
E
S
N
G
S
S
S
M
A
T
V
C
G
S
S
L
A
M
M
D
A
G
V
P
L
V
R
P
V
S
G
I
A
M
G
L
I
L
---
E
Q
-------
D
-------
G
F
A
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
T
S
E
G
L
T
S
L
Q
M
D
I
K
I
A
G
I
T
P
A
I
M
E
Q
A
L
A
Q
A
K
E
G
R
A
H
I
L
G
E
M
N
K
A
M
D
A
P
R
A
D
V
G
D
F
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
79.89
49%
-80
- C3 -
3H1C
2
PNP_ECOLI
M:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
79.88
49%
-75
- C3 -
3H1C
2
PNP_ECOLI
I:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.86
49%
-79
- C3 -
3GCM
6
PNP_ECOLI
A:
[11-545]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
E
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
79.82
49%
-78
- C3 -
3H1C
2
PNP_ECOLI
B:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
79.79
49%
-77
- C3 -
3H1C
2
PNP_ECOLI
R:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
79.61
49%
-79
- C3 -
3H1C
2
PNP_ECOLI
T:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
79.35
49%
-78
- C3 -
3H1C
3
PNP_ECOLI
K:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
79.22
49%
-79
- C3 -
3H1C
2
PNP_ECOLI
V:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
79.13
49%
-78
- C3 -
3H1C
2
PNP_ECOLI
G:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
79.00
49%
-79
- C3 -
3H1C
2
PNP_ECOLI
O:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
R
G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
L
A
V
M
P
D
M
D
K
F
P
Y
T
V
R
V
V
S
E
I
T
E
S
N
G
S
S
S
M
A
S
V
C
G
A
S
L
A
L
M
D
A
G
V
P
I
K
A
A
V
A
G
I
A
M
G
L
V
K
---
E
G
-------
D
-------
N
Y
V
V
L
S
D
I
L
G
D
E
D
H
L
G
D
M
D
F
K
V
A
G
S
R
D
G
I
S
A
L
Q
M
D
I
K
I
E
G
I
T
K
E
I
M
Q
V
A
L
N
Q
A
K
G
A
R
L
H
I
L
G
V
M
E
Q
A
I
N
A
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
78.77
49%
-79
- C3 -
3H1C
3
PNP_ECOLI
C:
[11-544]
---------
Y
G
-----
Q
H
T
V
T
L
E
T
G
M
M
A
R
Q
A
T
A
A
V
M
V
S
M
D
D
T
A
-
V
F
V
T
V
V
G
Q
K
K
A
K
P
-
G
Q-
D
F
F
P
L
T
V
N
Y
Q
E
R
T
Y
A
A
G
R
I
P
G
S
F
F
R
R
E
G
R
P
S
E
G
E
T
L
I
A
R
L
I
D
R
P
I
R
P
L
F
P
E
G
F
V
N
E
V
Q
V
I
A
T
V
V
S
V
N
P
Q
V
N
P
D
I
V
A
M
I
G
A
S
A
A
L
S
L
S
G
I
P
F
N
G
P
I
G
A
A
R
V
G
Y
I
N
D
Q
Y
V
L
N
P
T
Q
D
E
L
K
E
S
K
L
D
L
V
V
A
G
-----------------
T
-----
E
-
A
A
V
L
M
V
E
S
E
A
Q
L
L
S
E
D
Q
M
------------
L
G
A
V
V
F
G
H
E
Q
Q
Q
V
V
I
Q
N
I
N
E
L
V
K
E
A
G
-
K
P
R
W
D
W
Q
-
P
-
E
P
-
V
N
E
A
L
N
A
R
V
A
A
L
A
E
A
R
L
S
D
A
Y
R
--
I
-----
T
D
--
K
Q
E
R
Y
A
Q
V
D
V
I
K
----
S
E
T
I
A
T
L
---
L
A
E
D
E
T
L
D
E
--
N
E
L
G
E
I
L
H
A
I
E
K
N
V
V
R
S
R
V
L
A
G
E
P
R
I
D
G
R
E
K
D
M
I
R
G
L
D
V
R
T
G
V
L
P
R
T
H
G
S
A
L
F
T
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G
E
T
Q
A
L
V
T
A
T
L
----
G
T
A
R
D
A
----
Q
V
L
D
E
L
M
G
E
R
T
D
T
F
L
F
H
Y
N
F
P
P
Y
S
V
G
E
T
G
M
V
G
S
P
K
R
R
E
I
G
H
G
R
L
A
K
R
G
V
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M
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D
M
D
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Y
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C
G
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A
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A
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A
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A
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---
E
G
-------
D
-------
N
Y
V
V
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I
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D
H
L
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P
------------------------------------------------------------------------------------------------------------------------------------------------------------------