@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0202: (2015-11-29 )
MIKIYDTMTRSLQDFIPLNEGKVNMYVCGPTVYNYIHIGNARSVVAFDTIRRYFEYCGYQVNYISNFTDVDDKIIKGAAEAGMDTKSFSDKFISAFMEDVAALGVKPATKNPRVIDYMDEIIDFVKVLVDKEFAYEANGDVYFRVSKSHHYAKLANKTLEDLEIGASGRVDGEGEIKENPLDFALWKSAKSGEVSWESPWGKGRPGWHIECSVMATEILGDTIDIHGGGADLEFPHHTNEIAQSEAKTGKTFANYWMHNGFVNVDNEKMSKSLGNFITVHDMLKSVDGQVIRFFLATQQYRKPVNFTEKAVHDAEVNLKYLKNTFNLPIQENANDEELEQFVKAFQEAMDDDFNTANGITVIFEMAKWINSGHYTSKVKETLAELLEIFGIVFQEEVLDADIESLIEQRQEARANRDFATADRIRDELAKQGIKLLDTKDGVRWTRD
Atome Classification :
(20 SA)
.........10........20..-......30........40..-......50........60........70--.....----------------------------------------------------.------------------------------------------------...----80-----.---.-------------------------------------------.-..------------.------------...90........100....-...-110...--.--.--...--120.......130.....-----.----.140......------------.------------150----------------.------------------------------------.---.--------------------------------------------------------------------------.------.---.-------------------------------.------------------160.--------.-----.------...------------------.-----------------------------------------------..170----------.-------------.-.-----.----------.--------..--..-----180-------------------.-----------------.-----------------------.--..---.------------..190-.----.....----.---.200---......-----.--..210----------..---.-------------------------------------.--------------------.----------------.---------------..---------.----------------------220---------.----........230.......240......---------.-250--........--260.-.-.-.--...270.....--..280-.-.---------------------------.----------------------------....290.....-.-.300........310...--.--...320.....------..330.-----------------------------.-------------------------.....340-------........350.......360....--.--..370----.-----...------------------.--------------...380....-...390..------------.--------------...----------.400.......410.......420.......430.......440.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
I
K
I
Y
D
T
M
T
R
S
L
Q
D
FIPLNEG
K
V
-
N
M
Y
V
CGP
T
V
Y
N
Y
I
H
IGNA
R
S
-
V
V
A
F
D
T
I
R
R
Y
F
E
Y
CG
Y
Q
V
N
Y
ISNFTDV---
D
D
K
I
I
----------------------------------------------------
K
------------------------------------------------
G
A
A
----E------A---G-------------------------------------------M-DT------------
K
------------
S
F
S
D
K
F
I
S
A
F
M
E
D
V
A
ALGVK-PAT-K-NP
R
V
--
I
--
D
--
Y
M
D
--
E
I
I
D
F
V
K
V
L
VDKE
F
A
YEA-----N----G
D
V
Y
F
R
VSKS------------H------------
H
Y
A
----------------
K
------------------------------------
L
---
A
--------------------------------------------------------------------------
N
------
K
---
T
-------------------------------
L
------------------
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--
D
--------
L
-----E------IGA------------------S-----------------------------------------------GRV------------D-------------G-E-----G----------E--------IK--EN-----PL--------------------
D
-----------------
F
-----------------------
A
--
L
W---K------------SAKS--G----E
V
S
WE----S---PW-----GKGRPG-----
W
--
H
I
E
------------
C
S
---
V
-------------------------------------
M
--------------------
A
----------------
T
---------------
E
I---------L----------------------G-----------
D
----
T
I
D
IHGGGADLEFPHH
T
N
E
I
A
Q
S
EAKT---------G-
K
-
T
--
F
A
N
Y
W
MHN--
G
F
V
N-V-
D
-
N
--
E
K
M
S
K
S
LG
N
F
I
--
T
V
H
D
M
-
L
-
K
---------------------------S----------------------------V
D
G
Q
V
I
R
F
F
L
A
T
-
Q
-
Q
Y-RKPVN
F
T
E
K
AVHDAE--
V
--
N
L
K
Y
L
K
N
TFNL------PIQENA-----------------------------
N
-------------------------
D
E
E
L
E
Q
F
--------
V
K
A
F
Q
E
A
MDDDFNTAN
G
I
T
V
I
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A
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K
--
W
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NS-----G-----H
Y
T
------------------
S
--------------
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L
L
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I
F
G
I
V
F
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--------------
E
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----------
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A
D
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Q
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A
RANRDF
A
T
A
D
R
I
R
D
E
L
A
KQG
I
K
L
LDTKDGVRWTRD
3
PsiBlast_PDB
95.29
43%
-84
- C2 -
1U0B
1
SYC_ECOLI
B:
[1-460]
M
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
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G
M
Y
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T
V
Y
D
L
C
H
I
G
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T
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F
V
A
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V
V
A
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Y
L
R
F
L
G
Y
K
L
K
Y
V
R
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T
D
I
---
D
D
K
I
I
----------------------------------------------------
K
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A
N
----
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-------------------------------------------
E
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V
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M
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---
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--------
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A
G
A
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M
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G
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A
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M
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V
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D
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N
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T
V
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D
V
-
L
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K
---------------------------
Y
----------------------------
Y
D
A
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Y
F
L
M
S
-
G
-
H
Y
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R
S
Q
L
N
Y
S
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N
L
K
Q
A
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--
A
--
A
L
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R
L
Y
T
A
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-------
G
T
D
K
T
V
-----------------------------
A
-------------------------
P
A
G
G
E
A
F
--------
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
--
R
--
E
V
N
R
LKAED
M
-----
A
A
A
------------------
N
--------------
A
M
A
S
H
L
R
K
L
S
-
A
V
L
G
L
L
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Q
------------
E
PEAFLQSGAQADDS
E
V
------------
A
E
I
E
A
L
I
Q
Q
R
L
D
A
R
K
A
K
D
W
A
A
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A
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R
L
N
E
M
G
I
V
L
E
D
G
P
Q
G
T
T
W
R
R
K
63
Fugue
93.85
44%
-81
- C2 -
1U0B
1
SYC_ECOLI
B:
[1-461]
M
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
-
G
M
Y
V
C
G
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T
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Y
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C
H
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F
V
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L
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F
L
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Y
K
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Y
V
R
N
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D
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---
D
D
K
I
I
----------------------------------------------------
K
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R
A
N
----
E
------
N
---
G
-------------------------------------------
E
-
S
F
------------
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------------
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M
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M
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D
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N
----
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D
V
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T
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L
---
S
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---
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--------
L
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------
A
G
A
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-----------------------------------------------
V
D
V
------------
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--------------------------
K
--
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N
-----
P
M
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-----------------
F
-----------------------
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L
W
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------------
M
S
K
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--
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P
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G
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--
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I
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------------
C
S
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A
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M
--------------------
N
----------------
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---------------
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Q
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G
-----------
N
----
H
F
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H
G
G
G
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C
A
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D
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Q
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Y
V
N
Y
W
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--
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M
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M
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D
-
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--
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K
M
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S
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N
F
F
--
T
V
R
D
V
-
L
-
K
---------------------------
Y
----------------------------
Y
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
Y
-
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
R
--
A
--
A
L
E
R
L
Y
T
A
L
R
-------
G
T
D
K
T
V
-----------------------------
A
-------------------------
P
A
G
G
E
A
F
--------
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
--
R
--
E
V
N
R
-----
L
KAEDM
A
A
A
------------------
N
--------------
A
M
A
S
H
L
R
K
L
S
-
A
V
L
G
L
L
E
Q
EPEAFLQSGAQA
D
--------------
D
S
E
----------
V
A
E
I
E
A
L
I
Q
Q
R
L
D
A
R
K
A
K
D
W
A
A
A
D
A
A
R
D
R
L
N
E
M
G
I
V
L
E
D
G
P
Q
G
T
T
W
R
R
K
40
HHSearch
92.01
45%
-91
- C2 -
1LI5
1
SYC_ECOLI
A:
[1-402]
M
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
-
G
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
D
K
I
I
----------------------------------------------------
K
------------------------------------------------
R
A
N
----
E
------
N
---
G
-------------------------------------------
E
-
S
F
------------
V
------------
A
M
V
D
R
M
I
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M
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K
D
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D
A
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N
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L
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R
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D
-
M
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E
P
R
A
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T
--
H
--
H
I
A
--
E
I
I
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T
E
Q
L
I
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K
G
H
A
Y
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A
D----
N
----
G
D
V
M
F
D
V
P
T
D
------------
P
------------
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----------------
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------------------------------------
L
---
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R
------
Q
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K
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W
---
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------------
M
S
K
E
--
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P
S
W
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----
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P
W
-----
G
A
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P
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I
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------------
C
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---
A
-------------------------------------
M
--------------------
N
----------------
C
---------------
K
Q
---------
L
----------------------
G
-----------
N
----
H
F
D
I
H
G
G
G
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D
L
M
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N
E
I
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T
C
A
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D
-
G
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Q
--
Y
V
N
Y
W
M
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--
G
M
V
M
-
V
-
D
-
R
--
E
K
M
S
K
S
L
G
N
F
F
--
T
V
R
D
V
-
L
-
K
---------------------------
Y
----------------------------
Y
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
Y
-
R
S
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L
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Y
S
E
E
N
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K
Q
A
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A
--
A
L
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R
L
Y
T
A
L
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------
T
D
K
T
V
A
-------------------------------------------------------
P
A
G
G
E
A
F
--------
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
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A
Y
S
V
L
F
D
M
A
--
R
--
E
V
N
R
-----
L
-----
K
A
E
D
M
A
A
A
-------------
N
--------------
A
M
A
S
H
L
R
K
L
S
-
A
V
L
G
L
L
E
Q
------------
E
PEAFL-----------------------------------------------------------------------
2
PsiBlast_PDB
91.86
43%
-94
- C2 -
1LI7
2
SYC_ECOLI
A:
[1-402]
M
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
-
G
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
D
K
I
I
----------------------------------------------------
K
------------------------------------------------
R
A
N
----
E
------
N
---
G
-------------------------------------------
E
-
S
F
------------
V
------------
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
-
R
P
D
-
M
-
E
P
R
A
--
T
--
H
--
H
I
A
--
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
V
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D----
N
----
G
D
V
M
F
D
V
P
T
D
------------
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------------
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Y
G
----------------
V
------------------------------------
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---
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--------------------------------------------------------------------------
R
------
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--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
R
N
-----
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M
--------------------
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-----------------
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-----------------------
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--
L
W
---
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A
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I
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------------
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S
---
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-------------------------------------
M
--------------------
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---------------
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----------------------
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-----------
N
----
H
F
D
I
H
G
G
G
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L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
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---------
D
-
G
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Q
--
Y
V
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Y
W
M
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--
G
M
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M
-
V
-
D
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R
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E
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M
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L
G
N
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--
T
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D
V
-
L
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K
---------------------------
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----------------------------
Y
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
Y
-
R
S
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L
N
Y
S
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E
N
L
K
Q
A
R
--
A
--
A
L
E
R
L
Y
T
A
L
R
-------
G
T
D
K
T
V
-----------------------------
A
-------------------------
P
A
G
G
E
A
F
--------
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
--
R
--
E
V
N
R
L
K
A
ED
M
-----
A
A
A
------------------
N
--------------
A
M
A
S
H
L
R
K
L
S
-
A
V
L
G
L
L
E
Q
------------
E
PEAFL-----------------------------------------------------------------------
1
PsiBlast_PDB
91.38
43%
-92
- C2 -
1LI5
1
SYC_ECOLI
A:
[1-402]
M
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
-
G
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
D
K
I
I
----------------------------------------------------
K
------------------------------------------------
R
A
N
----
E
------
N
---
G
-------------------------------------------
E
-
S
F
------------
V
------------
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
-
R
P
D
-
M
-
E
P
R
A
--
T
--
H
--
H
I
A
--
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
V
A
D----
N
----
G
D
V
M
F
D
V
P
T
D
------------
P
------------
T
Y
G
----------------
V
------------------------------------
L
---
S
--------------------------------------------------------------------------
R
------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
R
N
-----
P
M
--------------------
D
-----------------
F
-----------------------
V
--
L
W
---
K
------------
M
S
K
E
--
G
----
E
P
S
W
P
----
S
---
P
W
-----
G
A
G
R
P
G
-----
W
--
H
I
E
------------
C
S
---
A
-------------------------------------
M
--------------------
N
----------------
C
---------------
K
Q
---------
L
----------------------
G
-----------
N
----
H
F
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
---------
D
-
G
-
Q
--
Y
V
N
Y
W
M
H
S
--
G
M
V
M
-
V
-
D
-
R
--
E
K
M
S
K
S
L
G
N
F
F
--
T
V
R
D
V
-
L
-
K
---------------------------
Y
----------------------------
Y
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
Y
-
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
R
--
A
--
A
L
E
R
L
Y
T
A
L
R
-------
G
T
D
K
T
V
-----------------------------
A
-------------------------
P
A
G
G
E
A
F
--------
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
--
R
--
E
V
N
R
L
K
A
E
D
M
-----
A
A
A
------------------
N
--------------
A
M
A
S
H
L
R
K
L
S
-
A
V
L
G
L
L
E
Q
------------
E
PEAFL-----------------------------------------------------------------------
22
PsiBlast_CBE
90.60
33%
-90
- C2 -
3SP1
3
SYC_BORBU
B:
[23-500]
I
L
K
L
Y
N
T
R
T
K
D
F
S
E
L
T
--
N
F
E
N
V
-
K
V
Y
A
C
G
P
T
V
Y
N
Y
A
H
I
G
N
F
R
T
-
Y
I
F
G
D
L
L
I
K
T
L
R
F
L
G
Y
K
V
N
Y
A
M
N
I
T
D
I
GH-----------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------
L
-
T
V
------------
Y
------------
E
I
S
E
F
F
T
E
A
F
F
N
D
C
R
K
L
N
I
V
-
Y
P
D
-
K
-
V
L
V
A
--
S
--
K
--
H
I
P
--
I
M
I
E
V
V
K
I
L
E
E
K
K
I
T
Y
F
S
-----
N
----
G
N
V
Y
F
D
T
S
C
F
------------
K
------------
S
Y
G
----------------
E
------------------------------------
M
---
A
--------------------------------------------------------------------------
G
------
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------
F
K
--
R
N
-----
K
T
--------------------
D
-----------------
F
-----------------------
V
--
L
W
F
T
N
S
------------
K
F
K
D
--
Q
----
E
M
K
W
D
----
S
---
P
W
-----
G
F
G
Y
P
S
-----
W
--
H
L
E
------------
C
A
---
A
-------------------------------------
M
--------------------
N
----------------
L
---------------
E
Y
---------
F
----------------------
K
-----------
D
----
A
L
D
I
H
L
G
G
V
D
H
I
G
V
H
H
I
N
E
I
A
I
A
E
C
F
L
---------
N
-
K
-
K
--
W
C
D
V
F
V
H
G
--
E
F
L
I
-
M
-
D
-
Y
--
N
K
M
S
-----
F
I
--
T
V
K
D
L
-
E
D
Q
---------------------------
N
----------------------------
F
S
P
L
D
F
R
Y
L
C
L
T
-
S
-
H
Y
-
R
N
Q
L
K
F
S
L
D
N
L
Q
A
S
K
--
I
--
A
R
E
N
L
I
N
K
L
S
Y
F
Y
E
S
LD
P
V
D
L
N
T
-----------------------------
L
-------------------------
N
K
D
L
K
N
F
GF
S
V
E
K
E
Y
Y
D
S
F
V
E
K
I
S
F
D
L
N
V
A
Q
G
L
A
L
L
W
E
I
I
--
K
--
S
D
N
L
-----
S
------
F
V
------------------
S
--------------
K
L
R
--
L
A
F
I
F
D
E
I
M
S
L
N
L
R
------------
E
--------------
E
I
L
K
N
L
Q
N
HDVVI
D
E
N
M
K
A
L
I
E
E
R
R
I
A
K
C
E
K
N
F
K
R
A
D
E
I
R
D
F
F
A
K
K
G
F
V
L
V
D
---
G
T
K
V
K
R
G
4
PsiBlast_PDB
89.39
33%
-96
- C2 -
3SP1
2
SYC_BORBU
A:
[23-490]
I
L
K
L
Y
N
T
R
T
K
D
F
S
E
L
T
--
N
F
E
N
V
-
K
V
Y
A
C
G
P
T
V
Y
N
Y
A
H
I
G
N
F
R
T
-
Y
I
F
G
D
L
L
I
K
T
L
R
F
L
G
Y
K
V
N
Y
A
M
N
I
T
D
I
GHL------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-
T
V
------------
Y
------------
E
I
S
E
F
F
T
E
A
F
F
N
D
C
R
K
L
N
I
V
-
Y
P
D
-
K
-
V
L
V
A
--
S
--
K
--
H
I
P
--
I
M
I
E
V
V
K
I
L
E
E
K
K
I
T
Y
F
S
-----
N
----
G
N
V
Y
F
D
T
S
C
F
------------
K
------------
S
Y
G
----------------
E
------------------------------------
M
---
A
--------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
--
R
N
-----
K
T
--------------------
D
-----------------
F
-----------------------
V
--
L
W
F
T
N
S
------------
K
-----------
M
K
W
D
----
S
---
P
W
-----
G
F
G
Y
P
S
-----
W
--
H
L
E
------------
C
A
---
A
-------------------------------------
M
--------------------
N
----------------
L
---------------
E
Y
---------
F
----------------------
K
-----------
D
----
A
L
D
I
H
L
G
G
V
D
H
I
G
V
H
H
I
N
E
I
A
I
A
E
C
F
L
---------
N
-
K
-
K
--
W
C
D
V
F
V
H
G
--
E
F
L
I
-
M
-
D
-------------
F
I
--
T
V
K
D
L
-
E
D
Q
---------------------------
N
----------------------------
F
S
P
L
D
F
R
Y
L
C
L
T
-
S
-
H
Y
-
R
N
Q
L
K
F
S
L
D
N
L
Q
A
S
K
--
I
--
A
R
E
N
L
I
N
K
L
S
Y
F
Y
E
S
LD
P
V
D
L
N
T
-----------------------------
L
-------------------------
N
K
D
L
K
N
F
GF
S
V
E
K
E
Y
Y
D
S
F
V
E
K
I
S
F
D
L
N
V
A
Q
G
L
A
L
L
W
E
I
I
--
K
--
S
D
N
L
-----
S
------
F
V
------------------
S
--------------
K
L
R
--
L
A
F
I
F
D
E
I
M
S
L
N
L
R
------------
E
--------------
E
I
L
K
N
L
Q
N
H
D
V
V
I
D
E
N
M
K
A
L
I
E
E
R
R
I
A
K
C
E
K
N
F
K
R
A
D
E
I
R
D
F
F
A
K
K
G
F
V
L
V
-----------
21
PsiBlast_CBE
89.11
43%
-93
- C2 -
1LI7
2
SYC_ECOLI
B:
[1-402]
M
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
-
G
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
D
K
I
I
----------------------------------------------------
K
------------------------------------------------
R
-------------------------------------------------------------
E
-
S
F
------------
V
------------
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
-
R
P
D
-
M
-
E
P
R
A
--
T
--
H
--
H
I
A
--
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
V
A
D----
N
----
G
D
V
M
F
D
V
P
T
D
------------
P
------------
T
Y
G
----------------
V
------------------------------------
L
---
S
--------------------------------------------------------------------------
R
------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
-----
P
M
--------------------
D
-----------------
F
-----------------------
V
--
L
W
---
K
------------
M
S
K
E
--
G
----
E
P
S
W
P
----
S
---
P
W
-----
G
A
G
R
P
G
-----
W
--
H
I
E
------------
C
S
---
A
-------------------------------------
M
--------------------
N
----------------
C
---------------
K
Q
---------
L
----------------------
G
-----------
N
----
H
F
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
---------
D
-
G
-
Q
--
Y
V
N
Y
W
M
H
S
--
G
M
V
M
-
V
-
D
-
R
--
E
K
M
-----
N
F
F
--
T
V
R
D
V
-
L
-
K
---------------------------
Y
----------------------------
Y
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
Y
-
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
R
--
A
--
A
L
E
R
L
Y
T
A
L
R
-------
G
T
D
K
T
V
-----------------------------
A
-------------------------
P
A
G
G
E
A
F
--------
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
--
R
--
E
V
N
R
L
K
A
E
D
M
-----
A
A
A
------------------
N
--------------
A
M
A
S
H
L
R
K
L
S
-
A
V
L
G
L
L
E
Q
------------
E
PEAFL-----------------------------------------------------------------------
64
Fugue
85.54
44%
-75
- C2 -
1LI5
1
SYC_ECOLI
A:
[1-402]
M
L
K
I
F
N
T
L
T
R
Q
K
E
E
F
K
P
I
H
A
G
E
V
-
G
M
Y
V
C
G
I
T
V
Y
D
L
C
H
I
G
H
G
R
T
-
F
V
A
F
D
V
V
A
R
Y
L
R
F
L
G
Y
K
L
K
Y
V
R
N
I
T
D
I
---
D
D
K
I
I
----------------------------------------------------
K
------------------------------------------------
R
A
N
----
E
------
N
---
G
-------------------------------------------
E
-
S
F
------------
V
------------
A
M
V
D
R
M
I
A
E
M
H
K
D
F
D
A
L
N
I
L
-
R
P
D
-
M
-
E
P
R
A
--
T
--
H
--
H
I
A
--
E
I
I
E
L
T
E
Q
L
I
A
K
G
H
A
Y
V
A
D----
N
----
G
D
V
M
F
D
V
P
T
D
------------
P
------------
T
Y
G
----------------
V
------------------------------------
L
---
S
--------------------------------------------------------------------------
R
------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
R
N
-----
P
M
--------------------
D
-----------------
F
-----------------------
V
--
L
W
---
K
------------
M
S
K
E
--
G
----
E
P
S
W
P
----
S
---
P
W
-----
G
A
G
R
P
G
-----
W
--
H
I
E
------------
C
S
---
A
-------------------------------------
M
--------------------
N
----------------
C
---------------
K
Q
---------
L
----------------------
G
-----------
N
----
H
F
D
I
H
G
G
G
S
D
L
M
F
P
H
H
E
N
E
I
A
Q
S
T
C
A
H
---------
D
-
G
-
Q
--
Y
V
N
Y
W
M
H
S
--
G
M
V
M
-
V
-
D
-
R
--
E
K
M
S
K
S
L
G
N
F
F
--
T
V
R
D
V
-
L
-
K
---------------------------
Y
----------------------------
Y
D
A
E
T
V
R
Y
F
L
M
S
-
G
-
H
Y
-
R
S
Q
L
N
Y
S
E
E
N
L
K
Q
A
R
--
A
--
A
L
E
R
L
Y
T
A
L
R
-------
G
T
D
K
T
V
-----------------------------
A
-------------------------
P
A
G
G
E
A
F
--------
E
A
R
F
I
E
A
M
D
D
D
F
N
T
P
E
A
Y
S
V
L
F
D
M
A
--
R
--
E
V
N
R
-----
L
-----
K
A
E
------------------
D
-------------------------------------------------------------------------------------
M
A
A
A
N
A
M
A
S
H
L
R
K
L
S
A
V
L
G
------
L
L
E
Q
E
P
E
A
F
L
--
42
HHSearch
78.05
30%
-80
- C2 -
3C8Z
7
MSHC_MYCS2
A:
[20-413]
A
L
R
L
F
D
S
A
D
R
Q
V
R
P
V
T
P
G
--
P
T
A
-
T
M
Y
V
C
G
I
T
P
Y
D
A
T
H
L
G
H
A
A
T
-
Y
L
T
F
D
L
V
H
R
L
W
L
D
A
G
H
T
V
Q
Y
V
Q
N
V
T
D
V
---
D
D
P
L
F
----------------------------------------------------
E
------------------------------------------------
R
A
E
----
R
------
D
---
G
-------------------------------------------
I
-
D
W
------------
R
------------
T
L
G
D
R
E
T
Q
L
F
R
E
D
M
A
A
L
R
V
L
P
P
H
--
D
-
Y
V
A
A
--
T
--
D
--
A
I
A
--
E
V
V
E
M
V
E
K
L
L
A
S
G
A
A
Y
I
V
-----
E
DAEY
P
D
V
Y
F
R
A
D
A
T
------------
A
------------
Q
F
G
----------------
Y
------------------------------------
E
---
S
--------------------------------------------------------------------------
G
------
Y
---
D
-------------------------------
R
------------------
D
--
T
--------
M
-----
L
------
T
L
F
------------------
A
-----------------------------------------------
E
R
G
------------
G
-------------
D
-
P
D----
R
----------
P
--------
G
K
--
S
D
-----
Q
L
--------------------
D
-----------------
A
-----------------------
L
--
L
W
---
R
------------
A
E
R
P
--
G
----
E
P
S
W
P
----
S
---
P
F
-----
G
R
G
R
P
G
-----
W
--
H
V
E
------------
C
S
---
A
-------------------------------------
I
--------------------
A
----------------
L
---------------
T
R
---------
I
----------------------
G
-----------
T
----
G
L
D
I
Q
G
G
G
S
D
L
I
F
P
H
H
E
Y
S
A
A
H
A
E
S
V
T
---------
G
-
E
R
R
--
F
A
R
H
Y
V
H
T
--
G
M
I
G
------------------
V
--
L
V
S
Q
L
-
R
-
A
Q
--------------------------
G
----------------------------
V
D
P
S
A
I
R
L
G
L
F
S
-
G
-
H
Y
-
R
E
D
R
F
W
S
N
E
V
L
D
E
A
N
--
A
--
R
L
A
R
W
R
S
A
T
A
L
------
P
E
-----------------------------------------------------------
A
P
D
A
T
D
V
--------
I
A
R
V
R
Q
Y
L
A
D
D
L
D
T
P
K
A
L
A
A
L
D
G
W
C
--
T
--
D
A
L
S
-----
Y
-----
G
G
H
DT----------------
E
--------------
S
P
R
L
V
A
T
T
V
D
-
A
L
L
G
V
D
L
------------------------------------------------------------------------------------------
23
PsiBlast_CBE
74.03
32%
-79
- C2 -
3C8Z
5
MSHC_MYCS2
B:
[21-381]
-
L
R
L
F
D
S
A
D
R
Q
V
R
---
P
V
T
P
G
P
T
A
T
M
Y
V
C
G
I
T
P
Y
D
A
T
H
L
G
H
A
A
T
-
Y
L
T
F
D
L
V
H
R
L
W
L
D
A
G
H
T
V
Q
Y
V
Q
N
V
T
D
V
---
D
D
P
L
F
----------------------------------------------------
E
------------------------------------------------
R
A
E
----
R
------
D
---
G
-------------------------------------------
I
-
D
W
------------
R
------------
T
L
G
D
R
E
T
Q
L
F
R
E
D
M
A
A
L
R
V
L
-
P
P
H
-
D
-
Y
V
A
A
--
T
--
D
--
A
I
A
--
E
V
V
E
M
V
E
K
L
L
A
S
G
A
A
Y
I
V
-----
E
DAEY
P
D
V
Y
F
R
A
D
A
T
------------
A
------------
Q
F
G
----------------
Y
------------------------------------
E
---
S
--------------------------------------------------------------------------
G
YD
R
---
D
---
T
-------------------------------
M
------------------
L
--
T
--------
L
-----
F
------
A
E
R
------------------
G
-----------------------------------------------
G
D
P
------------
D
-------------
R
-
P
-----
G
--------------------
K
--
S
D
-----
Q
L
--------------------
D
-----------------
A
-----------------------
L
--
L
W
---
R
------------
A
E
R
P
--
G
----
E
P
S
W
P
----
S
---
P
F
-----
G
R
G
R
P
G
-----
W
--
H
V
E
------------
C
S
---
A
-------------------------------------
I
--------------------
A
----------------
L
---------------
T
R
---------
I
----------------------
G
-----------
T
----
G
L
D
I
Q
G
G
G
S
D
L
I
F
P
H
H
E
Y
S
A
A
H
A
E
S
V
T
---------
G
E
R
-
R
--
F
A
R
H
Y
V
H
T
--
G
M
I
G
------------------
V
--
L
V
S
Q
L
R
A
-
Q
---------------------------
G
----------------------------
V
D
P
S
A
I
R
L
G
L
F
S
-
G
-
H
Y
-
R
E
D
R
F
W
S
N
E
V
L
D
E
A
N
--
A
--
R
L
A
R
W
R
S
A
T
A
L
------
P
E
A
P
D
A
-----------------------------
T
-------------------------
D
-----
V
--------
I
A
R
V
R
Q
Y
L
A
D
D
L
D
T
P
K
A
L
A
A
L
D
G
W
C
--
T
--
D
A
L
S
-----
Y
-----
G
G
H
------------------
D
--------------
T
E
S
P
R
L
V
A
T
T
-
V
D
A
L
L
G
V
D
------------
L
----------------------------------------------------------------------------
5
PsiBlast_PDB
72.87
32%
-76
- C2 -
3C8Z
7
MSHC_MYCS2
A:
[21-381]
-
L
R
L
F
D
S
A
D
R
Q
V
R
---
P
V
T
P
G
P
T
A
T
M
Y
V
C
G
I
T
P
Y
D
A
T
H
L
G
H
A
A
T
-
Y
L
T
F
D
L
V
H
R
L
W
L
D
A
G
H
T
V
Q
Y
V
Q
N
V
T
D
V
---
D
D
P
L
F
----------------------------------------------------
E
------------------------------------------------
R
A
E
----
R
------
D
---
G
-------------------------------------------
I
-
D
W
------------
R
------------
T
L
G
D
R
E
T
Q
L
F
R
E
D
M
A
A
L
R
V
L
-
P
P
H
-
D
-
Y
V
A
A
--
T
--
D
--
A
I
A
--
E
V
V
E
M
V
E
K
L
L
A
S
G
A
A
Y
I
V
-----
E
DAEY
P
D
V
Y
F
R
A
D
A
T
------------
A
------------
Q
F
G
----------------
Y
------------------------------------
E
---
S
--------------------------------------------------------------------------
G
YD
R
---
D
---
T
-------------------------------
M
------------------
L
--
T
--------
L
-----
F
------
A
E
R
------------------
G
-----------------------------------------------
G
D
P
------------
D
-------------
R
-
P
-----
G
--------------------
K
--
S
D
-----
Q
L
--------------------
D
-----------------
A
-----------------------
L
--
L
W
---
R
------------
A
E
R
P
--
G
----
E
P
S
W
P
----
S
---
P
F
-----
G
R
G
R
P
G
-----
W
--
H
V
E
------------
C
S
---
A
-------------------------------------
I
--------------------
A
----------------
L
---------------
T
R
---------
I
----------------------
G
-----------
T
----
G
L
D
I
Q
G
G
G
S
D
L
I
F
P
H
H
E
Y
S
A
A
H
A
E
S
V
T
---------
G
E
R
-
R
--
F
A
R
H
Y
V
H
T
--
G
M
I
G
------------------
V
--
L
V
S
Q
L
R
A
-
Q
---------------------------
G
----------------------------
V
D
P
S
A
I
R
L
G
L
F
S
-
G
-
H
Y
-
R
E
D
R
F
W
S
N
E
V
L
D
E
A
N
--
A
--
R
L
A
R
W
R
S
A
T
A
L
------
P
E
A
P
D
A
-----------------------------
T
-------------------------
D
-----
V
--------
I
A
R
V
R
Q
Y
L
A
D
D
L
D
T
P
K
A
L
A
A
L
D
G
W
C
--
T
--
D
A
L
S
-----
Y
-----
G
G
H
------------------
D
--------------
T
E
S
P
R
L
V
A
T
T
-
V
D
A
L
L
G
V
D
------------
L
----------------------------------------------------------------------------
51
HHSearch
62.53
20%
-76
- C2 -
1FFY
4
SYI1_STAAU
A:
[47-722]
-------------------
N
E
T
F
-
I
L
H
D
G
P
P
Y
A
N
G
N
L
H
M
G
H
A
L
N
-
K
I
L
K
D
F
I
V
R
Y
K
T
M
Q
G
F
Y
A
P
Y
V
P
G
W
D
T
H
---
G
L
P
I
E
----------------------------------------------------
Q
------------------------------------------------
A
L
T
----
K
------
K
---
G
-------------------------------------------
V
-
D
R
KKMS
T
A
E
F
R
E
K
C
K
------------
E
F
A
L
E
Q
I
E
L
Q
K
K
D
F
R
R
L
G
V
R
-
G
D
F
N
D
-
P
Y
I
T
--
L
K
P
E
--
Y
E
A
--
A
Q
I
R
I
F
G
E
M
A
D
K
G
L
I
Y
K
G
-----
K
----
K
P
V
Y
W
S
P
S
S
E
------------
S
S
L
A
EAE
I
-----
E
Y
H
----------------
D
K
R
S
A
S
I
Y
V
A
F
N
-------------------------
V
---
K
DDKGVVDAD
A
K
F
I
I
W
T
TTPWTIPSN
V
A
I
T
V
HPELKYGQYNVNGEK
Y
I
I
A
E
ALSDAVAEALDWDKAS
I
K
L
E
KEYT
G
------
K
---
E
-------------------------------
L
EWV
V
A
Q
H
P
FLDR
E
S
L
V
I
N
G
--
D
HVT-----
T
-----
D
------
A
G
T
G
C
----------------
V
H
T
A
PGHGEDDYIVGQQYEL
P
V
I
S
P
I
D
DKGVFTEEGGQFEGMFYDKAN
K
A
V
------------
T
-------------
D
L
L
-----
T
EKGA
L
L
K
L
D
F
I
T
H
S
Y
P
H
DW
R
T
--
K
K
-----
P
V
--------------------
I
-----------------
F
R
A
T
P
Q
W
F
A
SISKV
R
Q
D
I
L
D
A
I
E
N
T
--
N
F
---
K
V
N
W
G
K
T
R
I
Y
N
M
V
R
D
R
G
--
E
W---
V
I
S
R
Q
----
R
---
V
W
-----
G
V
P
L
P
V
-----
F
--
Y
A
E
------------
N
G
---
E
-------------------------------------
I
I
M
T
K
E
T
V
N
H
V
A
D
L
F
A
E
HGS
N
I
W
F
E
R
EA----------
K
DLLPEGFTHPGSPNG
T
F
T
K
E
TDIMD
V
W
F
D
S
G
S
S
HRGVLETRPEL-----
S
-----------
F
----
P
A
D
M
Y
L
E
G
S
D
Q
Y
R
G
W
F
N
S
S
I
T
T
S
V
A
T
R
---------
G
-
V
-
S
--
P
Y
K
F
L
L
S
H
--
G
F
V
M
-
D
-
G
E
G
--
K
K
M
S
K
S
L
G
N
V
I
--
V
P
D
Q
V
-
V
-
K
---------------------------
Q
----------------------------
K
G
A
D
I
A
R
L
W
V
S
S
-
T
-
D
Y
-
L
A
D
V
R
I
S
D
E
I
L
K
Q
T
S
--
D
--
D
Y
R
K
I
R
N
T
L
R
F
------
M
L
G
N
I
N
DFNPDTDSIPESELL
E
V
D
R
Y
---------
L
-------------------------
L
N
R
L
R
E
F
--------
T
A
S
T
I
N
N
Y
-
E
N
F
D
Y
L
N
I
Y
Q
E
V
Q
N
F
I
--
N
VE
L
S
N
F
-----
Y
-----
L
D
Y
------------------
G
--------------
K
D
I
L
Y
I
E
Q
R
D
-
S
H
I
R
R
S
M
Q
------------
T
--------------
V
L
Y
----------
Q
I
L
V
D
M
T
K
L
L
A
P
I
L
V
H
T
A
E
E
V
W
S
H
T
P
H
V
K
E
E
S
V
H
L
A
D
M
P
K
V
V
E
V
D
Q
A
L
L
46
HHSearch
56.53
16%
-67
* C2 *
3KFL
14
?
A:
[25-513]
-------------------
Q
K
V
F
-
F
A
T
T
P
I
Y
Y
V
N
A
S
P
H
I
G
H
V
Y
S
-
T
L
I
V
D
V
L
G
R
Y
H
R
V
K
G
E
E
V
F
V
M
T
G
T
D
E
H
---
G
Q
K
V
A
----------------------------------------------------
E
------------------------------------------------
A
A
A
----
K
------
Q
---
G
-------------------------------------------
V
-
S
P
------------
M
------------
D
F
T
T
S
V
S
S
E
F
K
Q
C
F
Q
E
M
N
Y
D
-
M
N
--
Y
-
F
I
R
T
--
T
--
N
P
T
H
E
K
--
L
V
Q
D
I
W
K
K
L
A
A
K
G
D
I
Y
L
G
-----
K
----
Y
E
G
W
Y
S
V
S
D
E
------------
S
F
L
T
AQNV
A
D
G
V
D
R
D
G
----------------
K
------------------------------------
P
---
C
--------------------------------------------------------------------------
K
V
S
LESG
H
---
V
-------------------------------
V
------------------
T
--
W
--------
V
-----
E
------
E
E
N
Y
M
F
RLSAF----------
R
-----------------------------------------------
E
R
L
------------
L
-------------
K
------------------
Y
--------
F
H
--
D
H
P
NCIV
P
E
--------------------
F
R
R
R
E
-------------
V
-----------------------
I
--
K
T
---
V
------------
E
K
G
L
--
F
DL--
S
I
S
R
K
RESV
M
---
N
W
-----
S
I
P
V
P
G
DERHC
I
--
Y
V
W
------------
L
D
---
A
-------------------------------------
L
--------------------
F
----------------
N
---------------
Y
Y
---------
T
G
A
L
T
R
V
A
TDG
T
E
T
L
D
EDHHALN
R
-----------
W
----
P
A
D
V
H
V
V
G
K
D
I
L
K
F
H
A
I
Y
W
P
A
F
L
M
S
-
A
---------
E
-
L
-
P
--
L
P
E
R
L
V
S
H
--
G
W
W
T
-
K
-
D
-
H
--
K
K
I
S
K
S
L
G
N
A
F
--
D
P
V
E
K
-
A
-
K
---------------------------
E
----------------------------
F
G
I
D
A
L
K
Y
F
L
M
R
E
S
-
N
F
-
Q
D
D
G
D
Y
S
D
K
N
M
V
A
R
L
N
G
E
--
L
A
D
T
L
G
N
L
V
S
R
------
C
V
A
P
K
I
NVNGMW
P
E
P
A
E
YS
E
S
D
K
T
-----------
L
-------------------------
I
A
S
L
N
N
L
--------
A
G
T
V
D
H
Y
Y
-
C
L
P
D
I
Q
H
A
L
I
A
I
F
D
V
L
--
R
--
S
L
N
A
-----
Y
-----
V
T
E
------------------
N
APWKLVKMD
T
A
R
L
G
T
V
L
Y
V
T
M
E
G
L
-
R
I
C
T
M
F
L
-------------
Q
--------------
P
V
M
----------
P
Q
K
A
K
E
I
M
D
A
L
G
V
P
E
A
A
R
V
G
M
E
N
Y
L
F
G
I
V
K
P
G
T
K
I
A
G
L
A
E
G
Q
V
V
F
Q
K
V
T
57
HHSearch
55.96
18%
-69
- C2 -
3FNR
5
SYR_CAMJE
A:
[27-450]
-----------------
K
K
Q
E
S
F
-
L
L
E
Y
V
S
A
N
P
T
G
P
L
H
I
G
H
A
R
G
-
A
V
F
G
D
T
L
T
R
L
A
R
H
L
G
Y
K
F
N
T
E
Y
Y
V
N
D
A
---
G
N
Q
I
Y
----------------------------------------------------
L
------------------------------------------------
L
G
L
----
S
------
I
L
L
S
V
K
E
SILH
E
N
V
E
Y
P
E
Q
Y
Y
K
G
E
Y
I
V
D
L
A
K
E
A
F
E
K
FGKEFFSEEN
I
P
S
-
L
A
------------
D
------------
W
A
K
D
K
M
L
V
L
I
K
Q
N
L
E
Q
A
K
I
K
-
I
D
--
S
-
Y
V
S
E
--
R
--
S
--
Y
Y
D
--
A
L
N
A
T
L
E
S
L
K
E
H
K
G
I
Y
E
Q
-----
E
----
G
K
I
W
L
A
S
S
Q
K
---------------------------
G
----------------
D
------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------
D
R
V
---------------------------------------------
I
--------
I
R
--
E
D
------------------------------------------------------------------------------------------------
G
----
R
G
T
Y
L
----
A
---
A
----------------------
D
------------
I
V
---
Y
-------------------------------------
H
--------------------
K
----------------
D
---------------
K
M
S
--------
R
----------------------
G
-----------
Y
----
G
K
C
I
N
I
W
G
A
D
H
H
G
Y
I
-
P
R
M
K
A
A
M
E
-
F
L
---------
G
-
F
-
D
SN
N
L
E
I
I
L
A
Q
--
M
V
S
L
-
L
K
D
-
G
EP
Y
K
M
---
A
G
N
F
I
--
L
M
S
D
V
-
V
-
D
---------------------------
E
----------------------------
I
G
S
D
A
L
R
Y
I
F
L
S
-
K
-
K
C
-
D
T
H
L
E
F
D
I
S
D
L
Q
K
E
D
SS
N
--
P
V
Y
Y
I
N
Y
A
H
A
R
------
I
H
Q
V
F
A
K
A
GKKIDDVMKADLQSLN
Q
D
G
V
N
------
L
-------------------------
L
F
E
A
L
N
L
--------
K
A
V
L
N
D
A
F
-
E
A
R
A
L
Q
K
I
P
D
Y
L
K
N
L
A
--
A
--
N
F
H
K
-----
F
-----
Y
N
E
N
KVVGSAN
E
N
D
L
L
K
L
F
--
S
--------------
L
V
A
L
S
I
K
T
A
F
-
S
L
M
G
I
E
A
K
------------
N
--------------
K
M
------------------------------------------------------------
43
HHSearch
55.39
15%
-68
- C2 -
1RQG
2
SYM_PYRAB
A:
[2-471]
--------------------
V
R
Y
-
M
V
T
S
A
L
P
Y
A
N
G
P
I
H
A
G
H
L
A
G
A
Y
L
P
A
D
I
F
V
R
Y
L
R
L
K
G
E
D
V
V
F
I
C
G
T
D
E
H
---
G
T
P
I
S
----------------------------------------------------
F
------------------------------------------------
R
A
L
----
K
------
E
---
G
-------------------------------------------
R
-
S
P
------------
R
------------
E
I
V
D
E
F
H
E
Q
I
K
I
T
F
Q
R
A
K
I
S
-
F
D
--
F
-
F
G
R
T
--
E
L
P
I
--
H
Y
K
--
L
S
Q
E
F
F
L
K
A
Y
E
N
G
H
L
V
K
K
-----
V
----
T
K
Q
A
Y
C
E
H
D
K
M
F
L
P
DRF
V
I
G
T
C
P
------------
Y
C
G
A
E
D
QKG----------
D
------------------------------------
Q
CEV
C
--------------------------------------------------------------------------
G
------
R
---
P
-------------------------------
L
------------------
T
PE
I
--------
L
-----
I
NPRCAI
C
G
-------------------------------------------------------------------
R
P
I
S
F
R
D
S
A
H
Y
Y
I
KM
Q
-------------
D
-
F
A
E
R
L
K
R
----------
W
--------
I
E
K
Q
P
W
-----
K
P
NV
K
N
----------------
M
-----------------
V
-----------------------
L
--
S
W
---
I
------------
E
E
G
L
EE
R
----
A
I
T
R
D
----
L
---
N
W
-----
G
I
P
V
P
L
-----
D
--
E
E
D
MKGKVLYVWFE
A
P
I
---
G
-------------------------------------
Y
--------------------
I
S
I
T
I
E
H
F
K
R
I
GKPNEW
K
---------------
K
Y
---------
W
----------------------
L
-----------
N
ID
G
Q
T
R
V
I
H
F
I
G
K
D
N
I
P
F
H
A
I
F
W
P
A
F
L
M
A
Y
G
K
Y
K
D
EEVE
A
E
-
W
-
N
--
L
P
Y
D
I
P
A
N
--
E
Y
L
T
-
L
-
E
-
G
--
K
K
F
S
T
S
R
N
W
A
I
--
W
V
H
E
F
-
L
-
D
---------------------------
V
----------------------------
F
P
A
D
Y
L
R
Y
Y
L
T
T
-
I
-
M
P
E
T
R
D
S
D
F
S
F
S
D
F
K
V
R
I
--
N
E
E
L
V
N
N
L
G
N
F
V
H
R
------
A
L
T
F
V
N
R
YFDG
V
V
P
E
R
G
E
LD
E
L
D
R
E
----------
A
-------------------------
L
E
E
I
E
K
A
--------
F
K
E
V
G
E
L
I
-
M
N
Y
R
F
K
D
A
L
K
R
V
M
S
L
A
--
S
--
F
G
N
R
-----
Y
-----
F
D
H
------------------
K
--------------
Q
P
W
K
T
A
K
E
D
K
-
V
R
T
G
T
T
V
N
------------
I
--------------
S
L
Q
----------
I
V
K
A
L
G
I
L
L
E
P
F
L
P
D
A
S
E
K
I
W
H
L
L
N
L
D
E
V
K
R
W
E
F
R
E
L
P
A
G
H
K
V
R
K
P
E
I
L
59
HHSearch
55.31
17%
-72
- C2 -
1F7U
1
SYRC_YEAST
A:
[141-603]
------------------
E
N
K
K
V
-
I
I
E
F
S
S
P
N
I
A
K
P
F
H
A
G
H
L
R
S
-
T
I
I
G
G
F
L
A
N
L
Y
E
K
L
G
W
E
V
I
R
M
N
Y
L
G
D
W
---
G
K
Q
F
G
----------------------------------------------------
L
L
A
V
G
F
E
R
YGN
E
E
A
L
V
K
D
P
I
H
H
L
F
D
V
Y
V
R
I
N
K
D
I
E
E
E
GDSIPLEQST
N
G
K
A
R
----
E
Y
F
K
R
M
E
D
---
G
D
E
E
A
L
--------------------------------------
K
-
I
W
------------
K
------------
R
F
R
E
F
S
I
E
K
Y
I
D
T
Y
A
R
L
N
I
K
-
Y
D
--
V
-
Y
S
G
E
--
S
--
Q
--
V
S
K
E
-
S
M
L
K
A
I
D
L
F
K
E
K
G
L
T
H
E
D
-----
K
----
G
A
V
L
I
D
L
T
K
F
---------------------------
N
----------------
K
------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------
L
-------------
G
-------------------------------------------------------------------
K
A
I
---------------------------------------------
V
--------
Q
K
--
S
D
------------------------------------------------------------------------------------------------
G
----
T
T
L
Y
L
----
T
---
R
----------------------
D
------------
V
G
---
A
-------------------------------------
A
--------------------
M
----------------
D
---------------
R
Y
E
K
-------
Y
----------------------
H
-----------
F
----
D
K
M
I
Y
V
I
A
S
Q
Q
D
L
-
H
A
-
A
Q
F
F
E
I
L
K
Q
M
---------
G
-
F
-
E
--
W
A
K
D
L
Q
H
V
--
N
F
G
M
-
V
-
Q
-----
G
M
S
T
R
K
G
T
V
V
--
F
L
D
N
I
-
L
-
E
---------------------------
E
T
K
E
K
M
H
E
V
M
K
KN
E
N
K
Y
A
Q
IEH
P
E
E
V
A
D
L
V
G
I
S
A
V
M
I
Q
D
M
Q
-
G
-
K
R
-
I
N
N
Y
E
F
K
W
E
R
M
L
S
F
E
G-
D
--
T
G
P
Y
L
Q
Y
A
H
S
R
------
L
R
S
V
E
R
-----------------------------
N
A
SGIT
Q
E
K
W
I
N
ADFSLLKE
P
A
A
K
L
L
I
R
L
L
G
Q
Y
--------
P
D
V
L
R
N
A
I
-
K
T
H
E
P
T
T
V
V
T
Y
L
F
K
L
T
--
H
--
Q
V
S
S
-----
C
-----
Y
D
V
LWVAGQT
E
E
L
A
T
A
R
L
A
L
Y
G
--------------
A
A
R
Q
V
L
Y
N
G
M
-
R
L
L
G
L
T
P
V
------------
E
--------------
R
M
------------------------------------------------------------
49
HHSearch
54.17
19%
-62
- C2 -
2D5B
1
SYM_THET8
A:
[3-419]
--------------------
K
V
F
-
Y
V
T
T
P
I
Y
Y
V
N
A
E
P
H
L
G
H
A
Y
T
-
T
V
V
A
D
F
L
A
R
W
H
R
L
D
G
Y
R
T
F
F
L
T
G
T
D
E
H
---
G
E
T
V
Y
----------------------------------------------------
R
------------------------------------------------
A
A
Q
----
A
------
A
---
G
-------------------------------------------
E
-
D
P
------------
K
------------
A
F
V
D
R
V
S
G
R
F
K
R
A
W
D
L
L
G
I
A
-
Y
D
D
---
F
I
R
T
--
T
--
E
E
R
H
K
K
--
V
V
Q
L
V
L
K
K
V
Y
E
A
G
D
I
Y
Y
G
-----
E
----
Y
E
G
L
Y
C
V
S
C
E
------------
R
------------
F
Y
T
EKELVEGLC-------
P
------------------------------------
I
---
H
--------------------------------------------------------------------------
G
------
R
---
P
-------------------------------
V
------------------
E
--
R
--------
R
-----
K
------
E
G
N
Y
F
F
RMEKY----------
R
-----------------------------------------------
P
W
L
------------
Q
-------------
E
------------------
Y
--------
I
Q
--
E
N
PDLIR
P
E
G
Y
R
-----------------
N
-----------------
E
V
----------------------
L
--
A
M
---
L
------------
A
E
P
I
--
G
DL--
S
I
S
R
P
----
K
SRV
P
W
-----
G
I
P
L
P
W
-----
D
EN
H
V
T
------------
F
V
W
F
D
A
-------------------------------------
L
--------------------
L
----------------
N
---------------
Y
V
---------
S
A
L
DYPE----------------
G
E
A
Y
R
T
F-----
W
----
P
H
A
W
H
L
I
G
K
D
I
L
K
P
H
A
V
F
W
P
T
M
L
K
A
-
A
---------
G
-
I
-
P
--
M
Y
R
H
L
N
V
G
--
G
F
L
L
G
P
-
D
-
G
--
R
K
M
S
K
T
L
G
N
V
V
--
D
P
F
A
L
-
L
-
E
---------------------------
K
----------------------------
Y
G
R
D
A
L
R
Y
Y
L
L
R
-
E
I
P
Y
-
G
Q
D
T
P
V
S
E
E
A
L
R
T
R
Y
E
A
D
--
L
A
D
D
L
G
N
L
V
Q
R
------
T
R
A
M
L
F
R
FAEGRIPEPVAGE---------------
E
-------------------------
L
A
E
G
T
G
L
--------
A
G
R
L
R
P
L
V
-
R
E
L
K
F
H
V
A
L
E
E
A
M
A
Y
V
--
K
--
A
L
N
R
-----
Y
-----
I
N
E
------------------
K
--------------
K
P
W
E
L
F
K
K
E
P
-
E
E
A
R
A
V
L
Y
------------
R
--------------
V
V
E
----------
G
L
R
I
A
S
I
L
L
T
P
A
M
P
D
K
M
A
E
L
R
R
A
L
G
L
K
E
E
V
R
L
E
E
A
E
R
W
G
L
A
E
P
R
P
I
P
E
E
55
HHSearch
53.53
21%
-65
- C2 -
2ZUE
2
SYR_PYRHO
A:
[117-587]
------------------
K
G
K
K
V
-
I
V
E
H
T
S
V
N
P
T
K
P
L
H
M
G
H
A
R
N
-
A
I
L
G
D
V
M
A
R
I
L
R
F
L
G
Y
E
V
E
V
Q
N
Y
I
D
D
L
---
G
I
Q
F
A
Q
V
Y
W
G
Y
L
R
L
K
E
E
F
E
R
I
M
N
E
L
R
E
R
GLKDNP
I
D
H
A
L
G
L
L
Y
V
E
V
N
R
R
L
E
D
NPEL
E
N
------------------------------------------------
E
I
R
----
D
I
M
K
K
L
E
S
---
G
-------------------------------------------
E
L
Y
G
------------
R
------------
K
L
A
E
E
V
V
R
A
Q
M
V
T
T
Y
K
L
G
V
K
-
Y
D
--
L
-
L
V
W
E
--
S
--
D
--
I
V
R
R
K
L
F
E
I
A
L
E
L
L
S
K
N
E
N
F
Y
I
P
SDGKY
R
----
G
A
F
V
M
D
L
R
K
L
--------------------------
F
P
----------------
D
------------------------------------
M
---
K
--------------------------------------------------------------------------
N
------
P
---
I
-------------------------------
L
------------------
V
--
L
--------
R
-----
R
S-----
D
G
-------------------------------------------------------------------------------------------------------------------
T
--------
A
T
--
Y
T
-----
G
K
--------------------
D
-----------------
I
-----------------------
A
Y
H
L
W
---
K
------------
F
G
K
I
--
D
VD
L
L
Y
K
E
W
D
----
S
T--
T
W
T
T
A
PD
G
K
S
M
P
N
-----
K
--
F
G
N
------------
A
N
---------------------------------------------------------------------------------------------------------------------------------------------------
I
V
I
N
V
I
G
A
E
Q
K
H
--
P
Q
L
A
I
K
Y
A
L
Q
L
L
---------
G
-
F
-
E
D
-
A
A
A
N
L
Y
H
L
A
Y
E
H
V
E
-
R
-
P
-
E
--
G
K
F
S
G
R
K
G
T
W
V
GF
T
V
D
E
V
-
I
-
Q
E
A
V
K
R
A
R
E
L
I
E
E
K
NPALS
D
E
E
K
A
E
V
A
E
K
----------------------------
V
G
I
G
A
I
R
Y
N
L
I
K
-
Y
-
S
P
-
D
K
K
I
I
F
R
W
E
D
V
L
N
F
E
G-
E
--
S
A
P
Y
I
Q
Y
A
H
A
R
------
C
S
S
I
L
R
K
A
E
E
E
GIKVD
P
E
T
L
F
K
N
ADFTKLS
E
R
E
R
E
L
-------------------------
V
I
M
L
S
K
F
--------
P
R
I
V
E
Q
A
G
-
K
D
V
K
P
H
L
I
A
W
F
A
N
E
L
A
--
S
--
L
F
N
K
-----
F
-----
Y
M
D
------------------
H
--------------
P
V
L
K
A
E
E
G
V
R
-
E
A
R
L
L
L
V
M
------------
A
--------------
V
E
Q
----------
V
L
K
N
A
L
Y
L
M
G
I
E
A
P
E
R
M
--------------------------------
50
HHSearch
52.39
16%
-65
- C2 -
1GAX
3
SYV_THETH
A:
[33-651]
-------------------
K
P
P
F
-
V
I
F
M
P
P
P
N
V
T
G
S
L
H
M
G
H
A
L
D
-
N
S
L
Q
D
A
L
I
R
Y
K
R
M
R
G
F
E
A
V
W
L
P
G
T
D
H
A
---
G
I
A
T
Q
----------------------------------------------------
V
------------------------------------------------
V
V
E
R
LLL
K
------
E
---
G
-------------------------------------------
K
-
T
R
------------
H
DLG
R
E
K
F
L
E
R
V
W
Q
W
K
E
E
S
G
G
T
I
L
K
Q
L
K
R
L
G
A
S
-
A
D
W
-
S
R
E
A
F
T
MD
E
--
K
--
R
S
R
--
A
V
R
Y
A
F
S
R
Y
Y
H
E
G
L
A
Y
R
A
-----
P
----
R
L
V
N
W
C
P
R
C
E
------------
T
------------
T
L
S
DLE
V
E
T
E
P
T
P
G
K
L
Y
T
L
R
Y
E
V
EG
G
G
F
I
E
I
A
T
VRPETVFADQ
A
I
A
V
HPEDERYRH
L
---
L
--------------------------------------------------------------------------
G
------
K
RAR
I
PLTE
V
W
I
P
I
L
A
D
PAVEKDFGTG
A
L
K
V
T
PAHD
P
------------------
L
--
D
Y
E
I
G
E
R
H
G
L
K
P
V
S
V
I
NL----
E
G
R
M
E
GERVPEALRGLD
R
F
E
A
R
-----------------------------------------------
R
K
A
------------
V
E
L
F
REAGHL
V
K
E
E
D
-
Y
-----
T
IAL-------
A
TCS-----
R
C
--
G
T
-----
P
I
E
Y
A
I
F
P
Q
W
W
L
R
M
R
P
L
A
E
E
V
L
K
G
L
R
R
GDIAFVPERW
K
K
V
N
-----------------------
M
--
D
W
---
L
------------
E
N
V
K
--
D
W---
N
I
S
R
Q
----
L
---
W
W
-----
G
H
Q
I
P
A
-----
W
--
Y
C
E
D-----------
C
Q
---
A
V
N
V
P
R
PERYLEDPTSCEACGSPRLKRDE
D
V
F
D
T
W
F
S
S
A
--------------------
L
----------------
W
---------------
P
L
ST-------
L
----------------------
G
WPEET
E
D
L
K
A
F
Y
----
P
G
D
V
L
V
T
G
Y
D
I
L
F
L
W
V
S
R
M
E
V
S
G
Y
H
F
M
---------
G
-
E
-
R
--
P
F
K
T
V
L
L
H
--
G
L
V
L
-
D
-
E
K
G
--
Q
K
M
S
K
S
K
G
N
V
I
--
D
P
L
E
M
-
V
-
E
---------------------------
R
----------------------------
Y
G
A
D
A
L
R
F
A
L
I
Y
-
L
A
T
G
-
G
Q
D
I
R
L
D
L
R
W
L
E
M
A
R
--
N
--
F
A
N
K
L
Y
N
A
A
R
F
------
V
L
L
S
R
E
GFQAK
E
D
T
P
T
L
A
D
R
F
--------------
M
-------------------------
R
S
R
L
S
R
G
--------
V
E
E
I
T
A
L
Y
-
E
A
L
D
L
A
Q
A
A
R
E
V
Y
E
L
V
W
S
E
--
F
C
D
W
-----
Y
-----
L
E
A
------------------
A
--------------
K
P
A
L
K
A
G
N
A
H
-
T
L
R
T
L
E
E
V
------------
L
--------------
A
V
L
----------
L
K
L
L
H
P
M
M
P
F
L
T
S
E
L
Y
Q
A
L
T
G
K
E
E
L
A
L
E
A
W
P
E
P
G
G
R
D
E
E
A
E
R
A
F
E
A
L
K
Q