@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0206: (2015-11-29 )
MTFKILTDSTSDLDEKWAQEHNVDIIGLTIELDGKTYETVGDEKITSDFLLERMQEGAKPTTSQINVGQFEEVFSTYAENDHALLYLALSSHLSGTYQSATIAREMVLDKYPDAQIEIVDTMAASCGEGVLAMLATKERQEGKSLEEVKQKIESLLPKLNTYFLVDDLNHLMRSGRLSKGAAIIGSVAKIKPLLKLDSEGKLVPFAKTRGRKKGIKEIVTQATKTLSYSTLIIAYSGEKDSAQVMKEQLLADERIEEVIIRPLGPVISAHVGSGALALFSLGEENR
Atome Classification :
(20 SA)
.........10........20........30.-...-..-..--40........---.50....-.-...--60........70........80.-.-......90........100.....--..110.......120.......130.......140-.-......150.....--.--.160.......170.......180.......190.......200.......210....---...----220..-.--.-----...230...---.....240..-.....250-.-...--...260.......270.......280....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
F
K
I
LTDSTS
D
L
D
E
K
W
A
Q
EHNV
D
I
I
G
L
T
I
E
L-DG
K
-
T
Y
-ET--V-GDEKI
T
S
D
---
F
L
L
E
R
M
Q-E-GAK--PTTSQIN
V
G
Q
F
E
E
V
F
S
T
YAEND
H
-
A
-
L
L
Y
L
A
L
S
S
HLSGT
Y
Q
S
A
T
I
A
R
E
M
V
--LDKYPDA
Q
I
E
I
V
D
T
M
A
A
S
C
G
E
G
V
L
A
M
L
A
T
K
E
R
QEG-K-
S
L
E
E
V
K
Q
K
I
E
S
L
L
P--K--L
N
T
Y
F
L
V
D
D
L
N
H
L
M
RSGRLSK
G
A
A
I
I
G
S
V
A
KI
K
P
L
LKLDSEG
K
L
V
P
F
A
KTRGRKK
G
I
K
---
E
I
V
----
T
Q
A
T
K-T--L-----
S
Y
S
T
L
-
I
I
A
---YSGEK
D
S
A
Q
V
-
M
K
E
Q
L
L
A
D
-
E
-
R
I
E
--
E
V
I
I
RPL
G
P
V
I
S
A
HVGS
G
A
L
A
L
FSLGEENR
1
PsiBlast_PDB
99.90
59%
-93
- C2 -
3PL5
1
?
A:
[36-320]
-
T
F
K
I
L
T
D
S
T
A
D
L
P
E
S
W
T
Q
E
N
D
V
Q
V
L
G
L
T
V
Q
L
-
D
G
I
-
T
Y
-
E
T
--
V
-
G
P
D
R
L
T
S
R
---
V
L
L
E
K
I
A
-
A
-
G
S
K
--
P
T
T
S
Q
V
N
V
G
Q
F
E
S
Y
F
R
Q
S
A
E
N
G
Q
-
E
-
V
L
Y
I
A
F
S
S
V
L
S
G
T
Y
Q
S
A
V
M
A
R
D
I
V
--
L
E
E
Y
P
Q
A
S
I
E
I
V
D
T
L
A
A
T
G
G
E
G
Y
L
A
M
L
A
A
Q
A
R
E
E
G
-
K
-
S
L
K
E
T
K
E
L
I
L
D
V
G
P
--
R
--
L
R
T
F
F
L
V
D
N
L
Y
H
L
M
R
G
G
R
L
S
--------
L
V
N
I
K
P
L
L
W
L
D
A
S
G
K
L
V
P
I
A
K
L
R
G
R
K
K
G
M
K
---
E
M
L
----
K
R
A
T
A
-
D
--
V
-----
A
H
D
T
A
-
V
V
A
---
Y
A
N
D
S
E
A
A
E
N
-
L
K
E
Q
L
L
A
N
-
E
-
K
I
K
--
N
V
V
T
L
P
L
G
P
V
I
S
T
H
V
G
P
N
T
L
A
V
F
T
I
G
K
E
A
R
19
HHSearch
99.65
59%
-93
- C2 -
3PL5
1
?
A:
[36-320]
-
T
F
K
I
L
T
D
S
T
A
D
L
P
E
S
W
T
Q
E
N
D
V
Q
V
L
G
L
T
V
Q
L
-
D
G
I
-
T
Y
-
E
T
VG
P
-
D
--
R
L
T
S
R
---
V
L
L
E
K
I
A
-
A
-
G
S
K
--
P
T
T
S
Q
V
N
V
G
Q
F
E
S
Y
F
R
Q
S
A
E
N
G
Q
-
E
-
V
L
Y
I
A
F
S
S
V
L
S
G
T
Y
Q
S
A
V
M
A
R
D
I
V
--
L
E
E
Y
P
Q
A
S
I
E
I
V
D
T
L
A
A
T
G
G
E
G
Y
L
A
M
L
A
A
Q
A
R
E
E
G
-
K
-
S
L
K
E
T
K
E
L
I
L
D
V
G
P
--
R
--
L
R
T
F
F
L
V
D
N
L
Y
H
L
M
R
G
G
R
L
S
--------
L
V
N
I
K
P
L
L
W
L
D
A
S
G
K
L
V
P
I
A
K
L
R
G
R
K
K
G
M
K
---
E
M
L
----
K
R
A
T
A
-
D
--
V
-----
A
H
D
T
A
-
V
V
A
---
Y
A
N
D
S
E
A
A
E
N
-
L
K
E
Q
L
L
A
N
-
E
-
K
I
K
--
N
V
V
T
L
P
L
G
P
V
I
S
T
H
V
G
P
N
T
L
A
V
F
T
I
G
K
E
A
R
14
HHSearch
86.91
33%
-92
- C2 -
1PZX
1
?
A:
[3-286]
M
P
I
E
I
I
T
D
S
G
A
D
L
P
Q
S
Y
I
R
E
H
R
I
A
F
L
P
L
V
V
H
W
-
N
G
Q
-
D
Y
-
K
D
--
G
-
I
--
T
I
E
P
K
---
Q
V
Y
D
A
M
R
-
Q
-
G
H
T
--
V
K
T
A
Q
P
S
P
L
A
M
K
E
L
F
L
P
Y
A
K
E
N
R
-
P
-
C
L
Y
I
A
F
S
S
K
L
S
G
T
Y
Q
T
A
M
A
V
R
S
E
L
--
L
D
E
Y
P
E
F
R
L
T
I
I
D
S
K
C
A
S
L
G
Q
G
L
A
V
M
K
A
V
E
L
A
K
Q
N
-
T
-
P
Y
N
L
L
C
E
T
I
E
S
Y
C
R
--
H
--
M
E
H
I
F
T
V
D
N
L
D
Y
L
A
R
G
G
R
I
S
----------
N
I
K
P
L
L
H
V
E
-
D
G
A
L
I
P
L
E
K
W
R
G
R
K
K
V
L
K
---
R
M
V
----
E
L
M
G
E
-
R
--
G
DDL--
Q
K
Q
T
I
-
G
I
S
---
H
A
D
D
E
E
T
A
L
E
-
L
K
Q
M
I
E
E
T
-
H
-
G
C
T
--
R
F
F
L
S
D
I
G
S
A
I
G
A
H
A
G
P
G
T
I
A
L
F
F
L
N
K
Y
I
E
2
PsiBlast_PDB
86.14
32%
-89
- C2 -
1PZX
1
?
A:
[3-285]
M
P
I
E
I
I
T
D
S
G
A
D
L
P
Q
S
Y
I
R
E
H
R
I
A
F
L
P
L
V
V
H
W
-
N
G
Q
-
D
Y
-
K
D
-----
G
I
T
I
E
P
K
---
Q
V
Y
D
A
M
R
-
Q
-
G
H
T
--
V
K
T
A
Q
P
S
P
L
A
M
K
E
L
F
L
P
Y
A
K
E
N
R
-
P
-
C
L
Y
I
A
F
S
S
K
L
S
G
T
Y
Q
T
A
M
A
V
R
S
E
L
--
L
D
E
Y
P
E
F
R
L
T
I
I
D
S
K
C
A
S
L
G
Q
G
L
A
V
M
K
A
V
E
L
A
K
Q
N
-
T
-
P
Y
N
L
L
C
E
T
I
E
S
Y
C
R
--
H
--
M
E
H
I
F
T
V
D
N
L
D
Y
L
A
R
G
G
R
I
S
----------
N
I
K
P
L
L
H
V
E
-
D
G
A
L
I
P
L
E
K
W
R
G
R
K
K
V
L
K
R
M
V
E
L
M
----
G
E
R
G
D
-
D
--
L
-----
Q
K
Q
T
I
-
G
I
S
---
H
A
D
D
E
E
T
A
L
E
-
L
K
Q
M
I
E
E
T
-
H
-
G
C
T
--
R
F
F
L
S
D
I
G
S
A
I
G
A
H
A
G
P
G
T
I
A
L
F
F
L
N
K
Y
I
E
13
PsiBlast_CBE
85.04
32%
-87
- C2 -
1PZX
1
?
B:
[3-285]
M
P
I
E
I
I
T
D
S
G
A
D
L
P
Q
S
Y
I
R
E
H
R
I
A
F
L
P
L
V
V
H
W
-
N
G
Q
-
D
Y
-
K
D
-----
G
I
T
I
E
P
K
---
Q
V
Y
D
A
M
R
-
Q
-
G
H
T
--
V
K
T
A
Q
P
S
P
L
A
M
K
E
L
F
L
P
Y
A
K
E
N
R
-
P
-
C
L
Y
I
A
F
S
S
K
L
S
G
T
Y
Q
T
A
M
A
V
R
S
E
L
--
L
D
E
Y
P
E
F
R
L
T
I
I
D
S
K
C
A
S
L
G
Q
G
L
A
V
M
K
A
V
E
L
A
K
Q
N
-
T
-
P
Y
N
L
L
C
E
T
I
E
S
Y
C
R
--
H
--
M
E
H
I
F
T
V
D
N
L
D
Y
L
A
R
G
G
R
I
S
K
T
A
A
A
F
G
G
L
L
N
I
K
P
L
L
H
V
E
-
D
G
A
L
I
P
L
E
K
W
R
G
R
K
K
V
L
K
R
M
V
E
L
M
----
G
E
R
G
D
-
D
--
L
-----
Q
K
Q
T
I
-
G
I
S
---
H
A
D
D
E
E
T
A
L
E
-
L
K
Q
M
I
E
E
T
-
H
-
G
C
T
--
R
F
F
L
S
D
I
G
S
A
I
G
A
H
A
G
P
G
T
I
A
L
F
F
L
N
K
Y
I
E
3
PsiBlast_PDB
82.49
33%
-88
- C2 -
2DT8
3
?
A:
[5-277]
----
L
V
T
D
S
T
S
D
L
P
Q
D
L
R
G
R
L
G
V
R
V
V
P
L
Y
V
N
L
-
S
G
A
-
I
Y
-
R
D
--
W
---
E
E
I
T
P
T
---
E
I
F
Q
K
V
R
-
E
-
G
A
A
F
-
P
T
T
S
Q
P
S
P
E
D
F
A
R
V
Y
R
E
A
L
E
E
A
D
-
H
-
V
L
S
L
H
I
S
G
K
L
S
G
T
V
Q
S
A
----
E
L
A
--
A
Q
E
F
P
-
G
R
V
T
V
V
D
T
Q
A
A
S
L
G
V
G
M
M
V
L
R
A
K
E
L
L
E
E
G
-
Q
-
S
L
E
A
V
L
A
E
L
E
R
L
R
R
--
D
--
H
F
V
R
F
S
V
A
T
L
E
F
L
K
R
G
G
R
I
G
G
A
Q
A
F
L
G
T
L
L
N
L
K
P
V
L
T
L
-
K
E
G
R
V
E
A
A
G
R
A
R
G
E
K
K
A
R
E
---
E
I
L
----
K
A
F
R
A
-
W
--
A
-----
E
G
R
K
R
-
I
R
A
Y
F
L
Y
S
G
D
E
D
A
V
A
A
-
L
R
Q
E
V
L
A
S
-
G
L
P
V
E
--
E
A
L
V
N
E
L
G
A
V
I
A
S
H
T
G
P
G
T
Y
G
F
Y
A
Y
S
L
---
16
HHSearch
81.56
32%
-88
- C2 -
2DT8
3
?
A:
[1-279]
M
R
I
T
L
V
T
D
S
T
S
D
L
P
Q
D
L
R
G
R
L
G
V
R
V
V
P
L
Y
V
N
L
-
S
G
A
-
I
Y
-
R
D
--
W
-
E
--
E
I
T
P
T
---
E
I
F
Q
K
V
R
E
G
-
A
A
F
--
P
T
T
S
Q
P
S
P
E
D
F
A
R
V
Y
R
E
A
L
E
E
A
D
-
H
-
V
L
S
L
H
I
S
G
K
L
S
G
T
V
Q
S
A
E
L
A
A
Q
E
F
------
P
G
-
R
V
T
V
V
D
T
Q
A
A
S
L
G
V
G
M
M
V
L
R
A
K
E
L
L
E
E
G
-
Q
-
S
L
E
A
V
L
A
E
L
E
R
L
R
R
--
D
--
H
F
V
R
F
S
V
A
T
L
E
F
L
K
R
G
G
R
I
G
G
A
Q
A
F
L
G
T
L
L
N
L
K
P
V
L
T
L
K
-
E
G
R
V
E
A
A
G
R
A
R
G
E
K
K
A
R
E
---
E
I
L
----
K
A
F
R
A
-
W
--
A
EGR--
K
R
I
R
A
-
Y
F
L
---
Y
S
G
D
E
D
A
V
A
A
-
L
R
Q
E
V
L
A
S
G
L
-
P
V
E
--
E
A
L
V
N
E
L
G
A
V
I
A
S
H
T
G
P
G
T
Y
G
F
Y
A
Y
S
L
---
20
HHSearch
77.17
30%
-84
- C2 -
3FYS
9
DEGV_BACSU
A:
[35-315]
M
N
I
A
V
V
T
D
S
T
A
Y
I
P
K
E
M
R
E
Q
H
Q
I
H
M
I
P
L
Q
V
V
F
-
R
E
E
-
T
Y
-
R
E
--
E
-
I
--
E
L
D
W
K
---
S
F
Y
E
E
V
K
K
H
-
N
E
L
--
P
T
T
S
Q
P
P
I
G
E
L
V
A
L
Y
E
E
L
G
K
S
-
Y
D
A
-
V
I
S
I
H
L
S
S
G
I
S
G
T
F
S
S
A
A
A
A
D
S
M
V
--
D
----
N
I
D
V
Y
P
F
D
S
E
I
S
C
L
A
Q
G
F
Y
A
L
K
A
A
E
L
I
K
N
G
-
A
S
S
P
E
D
I
I
K
E
L
E
E
M
K
K
--
T
--
V
R
A
Y
F
M
V
D
D
L
A
H
L
Q
R
G
G
R
L
S
S
A
Q
A
F
I
G
S
L
L
K
V
K
P
I
L
H
F
D
-
N
K
V
I
V
P
F
E
K
I
R
T
R
K
K
A
I
S
---
R
I
Y
----
E
L
L
D
E
-
D
--
A
SKG--
L
P
M
R
A
-
A
V
I
---
H
A
N
R
E
E
E
A
A
K
-
I
I
E
E
L
S
A
K
-
Y
-
P
H
V
--
E
F
Y
N
S
Y
F
G
A
V
I
G
T
H
L
G
E
G
A
L
G
I
C
W
C
F
K
---
18
HHSearch
76.88
29%
-88
- C2 -
3LUP
2
?
A:
[4-284]
M
K
L
A
L
I
T
D
T
S
A
Y
L
P
E
A
I
E
N
H
E
D
V
Y
V
L
D
I
P
I
I
I
-
D
G
K
-
T
Y
-
I
E
--
G
-
Q
--
N
L
T
L
D
---
Q
Y
Y
D
K
L
A
A
S
-
K
E
L
--
P
K
T
S
Q
P
S
L
A
E
L
D
D
L
L
C
Q
L
E
K
E
G
Y
T
H
-
V
L
G
L
F
I
A
A
G
I
S
G
F
W
Q
N
I
Q
F
L
I
E
E
H
------
P
N
L
T
I
A
F
P
D
T
K
I
T
S
A
P
Q
G
N
L
V
R
N
A
L
M
C
S
R
E
G
-
M
-
D
F
D
V
I
V
N
K
I
Q
S
Q
I
E
--
K
--
I
E
G
F
I
V
V
N
D
L
N
H
L
V
K
G
G
R
L
S
N
G
S
A
I
I
G
N
L
L
S
I
K
P
V
L
H
F
N
E
E
G
K
I
V
V
Y
E
K
V
R
T
E
K
K
A
L
K
---
R
L
A
----
E
I
V
K
E
-
M
--
T
AD---
G
E
Y
D
I
-
A
I
I
---
H
S
R
A
Q
D
K
A
E
Q
-
L
Y
N
L
L
A
K
A
-
G
-
L
K
D
--
D
L
E
I
V
S
F
G
G
V
I
A
T
H
L
G
E
G
A
V
A
F
G
I
T
P
K
N
--
22
HHSearch
76.57
31%
-76
- C2 -
1MGP
1
Y1468_THEMA
A:
[26-309]
M
K
V
K
I
L
V
D
S
T
A
D
V
P
F
S
W
M
E
K
Y
D
I
D
S
I
P
L
Y
V
V
W
-
E
D
G
R
S
E
-
P
D
--
E
R
E
--
P
E
E
I
M
---
N
F
Y
K
R
I
R
-
E
A
G
S
V
--
P
K
T
S
Q
P
S
V
E
D
F
K
K
R
Y
L
K
Y
K
E
E
D
Y
D
V
-
V
L
V
L
T
L
S
S
K
L
S
G
T
Y
N
S
A
V
L
A
S
K
E
V
-------
D
I
P
V
Y
V
V
D
T
L
L
A
S
G
A
I
P
L
P
A
R
V
A
R
E
M
L
E
N
G
-
A
-
T
I
E
E
V
L
K
K
L
D
E
R
M
K
N
K
D
--
F
K
A
I
F
Y
V
S
N
F
D
Y
L
V
K
G
G
R
V
---------
L
L
K
I
R
V
C
L
H
I
E
-
N
G
E
L
I
P
Y
R
K
V
R
G
D
K
K
A
I
E
---
A
L
I
----
E
K
L
R
E
-
D
--
T
PEG--
S
K
L
R
V
-
I
G
V
---
H
A
D
N
E
A
G
V
V
E
-
L
L
N
T
L
R
K
S
-
Y
-
E
V
V
--
D
E
I
I
S
P
M
G
K
V
I
T
T
H
V
G
P
G
T
V
G
F
G
I
E
V
L
---
4
PsiBlast_PDB
76.55
30%
-90
- C2 -
3LUP
2
?
A:
[8-279]
----
L
I
T
D
T
S
A
Y
L
P
E
A
I
E
N
H
E
D
V
Y
V
L
D
I
P
I
I
I
-
D
G
K
-
T
Y
-----
I
-
E
G
Q
N
L
T
L
D
---
Q
Y
Y
D
K
L
A
-
A
-
S
K
E
L
-
P
K
T
S
Q
P
S
L
A
E
L
D
D
L
L
C
Q
L
E
K
E
G
Y
-
T
H
V
L
G
L
F
I
A
A
G
I
S
G
F
W
Q
N
I
----
Q
F
L
--
I
E
E
H
P
N
L
T
I
A
F
P
D
T
K
I
T
S
A
P
Q
G
N
L
V
R
N
A
L
M
C
S
R
E
G
-
M
-
D
F
D
V
I
V
N
K
I
Q
S
Q
I
E
--
K
--
I
E
G
F
I
V
V
N
D
L
N
H
L
V
K
G
G
R
L
S
N
G
S
A
I
I
G
N
L
L
S
I
K
P
V
L
H
F
N
E
E
G
K
I
V
V
Y
E
K
V
R
T
E
K
K
A
L
K
R
L
A
E
I
V
----
K
E
M
T
A
-
D
--
G
-----
E
Y
D
I
A
-
I
I
----
H
S
R
A
Q
D
K
A
E
Q
-
L
Y
N
L
L
A
K
A
-
G
-
L
K
D
--
D
L
E
I
V
S
F
G
G
V
I
A
T
H
L
G
E
G
A
V
A
F
G
I
T
P
K
N
--
23
HHSearch
76.51
25%
-79
- C2 -
2G7Z
15
Y1493_STRP1
A:
[5-282]
G
T
I
K
I
V
T
D
S
S
I
T
I
E
P
E
L
I
K
A
L
D
I
T
V
V
P
L
S
V
M
I
-
D
S
K
-
L
Y
-
S
D
--
N
-
D
--
L
K
E
E
G
---
H
F
L
S
L
M
K
A
S
-
K
S
L
--
P
K
T
S
Q
P
P
V
G
L
F
A
E
T
Y
E
N
L
V
K
K
G
V
T
D
-
I
V
A
I
H
L
S
P
A
L
S
G
T
I
E
A
S
R
Q
G
A
E
I
A
-------
E
A
P
V
T
V
L
D
S
G
F
T
D
Q
A
M
K
F
Q
V
V
E
A
A
K
M
A
K
A
G
-
A
-
S
L
N
E
I
L
A
A
V
Q
A
I
K
S
--
K
--
T
E
L
Y
I
G
V
S
T
L
E
N
L
V
K
G
G
R
I
G
R
V
T
G
-----
L
N
V
K
V
V
M
A
L
K
-
N
D
E
L
K
T
L
V
K
G
R
G
N
K
T
F
T
K
---
W
L
D
----
S
Y
L
A
K
-
N
--
S
HR---
P
I
A
E
I
-
A
I
S
---
Y
A
G
E
A
S
L
A
L
T
-
L
K
E
R
I
A
A
Y
-
Y
-
N
-
H
--
S
I
S
V
L
E
T
G
S
I
I
Q
T
H
T
G
E
G
A
F
A
V
M
V
R
Y
E
---
6
PsiBlast_PDB
76.01
30%
-75
- C2 -
1VPV
3
Y1468_THEMA
A:
[16-291]
---
K
I
L
V
D
S
T
A
D
V
P
F
S
W
M
E
K
Y
D
I
D
S
I
P
L
Y
V
V
W
E
D
G
R
-
S
E
-
P
D
--
E
-
R
E
P
E
E
I
M
N
---
F
Y
K
R
I
R
E
-
A
-
G
S
V
--
P
K
T
S
Q
P
S
V
E
D
F
K
K
R
Y
L
K
Y
K
E
E
D
Y
D
V
-
V
L
V
L
T
L
S
S
K
L
S
G
T
Y
N
S
A
V
L
A
S
K
E
V
-------
D
I
P
V
Y
V
V
D
T
L
L
A
S
G
A
I
P
L
P
A
R
V
A
R
E
M
L
E
N
G
-
A
-
T
I
E
E
V
L
K
K
L
D
E
R
M
K
--
N
KD
F
K
A
I
F
Y
V
S
N
F
D
Y
L
V
K
G
G
R
V
-----
F
V
G
N
L
L
K
I
R
V
C
L
H
I
E
N
-
G
E
L
I
P
Y
R
K
V
R
G
D
K
K
A
I
E
---
A
L
I
----
E
K
L
R
E
D
T
--
P
-----
E
G
S
K
L
R
V
I
G
---
V
H
A
D
N
E
A
G
V
V
E
L
L
N
T
L
R
K
S
-
Y
-
E
V
V
--
D
E
I
I
S
P
M
G
K
V
I
T
T
H
V
G
P
G
T
V
G
F
G
I
E
V
L
E
R
K
15
HHSearch
75.19
25%
-78
- C2 -
3NYI
1
?
A:
[4-294]
-
M
Y
K
I
V
S
D
S
A
C
D
L
S
K
E
Y
L
E
K
H
D
V
T
I
V
P
L
S
V
S
F
-
D
G
E
-
T
Y
Y
R
D
--
G
-
V
--
D
I
T
R
D
---
E
C
Y
Q
R
M
V
D
D
P
K
L
F
--
P
K
T
S
L
P
S
V
E
S
Y
A
D
V
F
R
S
F
V
E
Q
G
F
-
P
-
V
V
C
F
T
I
T
T
L
F
S
G
S
Y
N
S
A
I
N
A
K
S
L
V
--
L
E
D
Y
P
D
A
N
I
C
V
I
D
S
K
Q
N
T
V
T
Q
A
L
L
I
D
Q
F
V
R
M
L
E
D
G
-
L
-
S
F
E
Q
A
M
S
K
L
D
A
L
M
A
--
S
--
A
R
I
F
F
T
V
G
S
L
D
Y
L
K
M
G
G
R
I
G
K
V
A
T
A
A
T
G
K
L
G
V
K
P
V
I
I
M
K
-
D
G
D
I
G
L
G
G
I
G
R
N
R
N
K
L
K
N
---
S
V
L
----
Q
V
A
K
K
-
Y
--
L
D
E
N
NK
D
N
F
I
V
-
S
V
G
---
Y
G
Y
D
K
E
E
G
F
E
-
F
M
K
E
V
E
S
T
-
L
-
D
V
K
LD
S
E
T
N
V
A
I
G
I
V
S
A
V
H
T
G
P
Y
P
I
G
L
G
V
I
R
K
Y
E
T
7
PsiBlast_PDB
74.53
32%
-71
- C2 -
3FYS
9
DEGV_BACSU
A:
[35-310]
M
N
I
A
V
V
T
D
S
T
A
Y
I
P
K
E
M
R
E
Q
H
Q
I
H
M
I
P
L
Q
V
V
F
-
R
E
E
-
T
Y
-
R
-------
E
E
I
E
L
D
W
K
S
F
Y
E
E
V
K
K
-
H
-
N
E
L
--
P
T
T
S
Q
P
P
I
G
E
L
V
A
L
Y
E
E
L
G
K
S
Y
D
-
A
-
V
I
S
I
H
L
S
S
G
I
S
G
T
F
S
S
A
A
A
A
D
S
M
V
DN
I
D
V
Y
P
------
F
D
S
E
I
S
C
L
A
Q
G
F
Y
A
L
K
A
A
E
L
I
K
N
G
A
S
-
S
P
E
D
I
I
K
E
L
E
E
M
K
K
--
T
--
V
R
A
Y
F
M
V
D
D
L
A
H
L
Q
R
G
G
R
L
S
S
A
Q
A
F
I
G
S
L
L
K
V
K
P
I
L
H
F
D
N
K
-
V
I
V
P
F
E
K
I
R
T
R
K
K
A
I
S
---
R
I
Y
E
L
L
D
E
D
A
S
K
-
G
--
L
-----
P
M
R
A
A
-
V
I
----
H
A
N
R
E
E
E
A
A
K
-
I
I
E
E
L
S
A
K
-
Y
-
P
H
V
--
E
F
Y
N
S
Y
F
G
A
V
I
G
T
H
L
G
E
G
A
L
G
I
C
W
C
F
K
---
5
PsiBlast_PDB
73.49
30%
-71
- C2 -
1MGP
1
Y1468_THEMA
A:
[29-304]
---
K
I
L
V
D
S
T
A
D
V
P
F
S
W
M
E
K
Y
D
I
D
S
I
P
L
Y
V
V
W
E
D
G
R
-
S
E
-
P
D
--
E
-
R
E
P
E
E
I
M
N
---
F
Y
K
R
I
R
E
-
A
-
G
S
V
--
P
K
T
S
Q
P
S
V
E
D
F
K
K
R
Y
L
K
Y
K
E
E
D
Y
D
V
-
V
L
V
L
T
L
S
S
K
L
S
G
T
Y
N
S
A
V
L
A
S
K
E
V
-------
D
I
P
V
Y
V
V
D
T
L
L
A
S
G
A
I
P
L
P
A
R
V
A
R
E
M
L
E
N
G
-
A
-
T
I
E
E
V
L
K
K
L
D
E
R
M
K
--
N
KD
F
K
A
I
F
Y
V
S
N
F
D
Y
L
V
K
G
G
R
V
---------
L
L
K
I
R
V
C
L
H
I
E
N
-
G
E
L
I
P
Y
R
K
V
R
G
D
K
K
A
I
E
---
A
L
I
----
E
K
L
R
E
D
T
--
P
-----
E
G
S
K
L
R
V
I
G
---
V
H
A
D
N
E
A
G
V
V
E
L
L
N
T
L
R
K
S
-
Y
-
E
V
V
--
D
E
I
I
S
P
M
G
K
V
I
T
T
H
V
G
P
G
T
V
G
F
G
I
E
V
L
---
10
PsiBlast_PDB
72.72
24%
-68
- C2 -
2G7Z
15
Y1493_STRP1
A:
[6-277]
-
T
I
K
I
V
T
D
S
S
I
T
I
E
P
E
L
I
K
A
L
D
I
T
V
V
P
L
S
V
M
I
-
D
S
K
-
L
Y
-
S
D
----
N
D
L
K
E
E
G
H
---
F
L
S
L
M
K
A
-
S
-
K
S
L
--
P
K
T
S
Q
P
P
V
G
L
F
A
E
T
Y
E
N
L
V
K
K
G
V
-
T
D
I
V
A
I
H
L
S
P
A
L
S
G
T
I
E
A
S
R
Q
G
A
E
I
A
-------
E
A
P
V
T
V
L
D
S
G
F
T
D
Q
A
M
K
F
Q
V
V
E
A
A
K
M
A
K
A
G
-
A
-
S
L
N
E
I
L
A
A
V
Q
A
I
K
S
--
K
--
T
E
L
Y
I
G
V
S
T
L
E
N
L
V
K
G
G
R
I
G
R
V
T
G
-----
L
N
V
K
V
V
M
A
L
K
N
D
-
E
L
K
T
L
V
K
G
R
G
N
K
T
F
T
K
---
W
L
D
----
S
Y
L
A
K
-
N
SH
R
-----
P
I
A
E
I
-
A
I
S
---
Y
A
G
E
A
S
L
A
L
T
-
L
K
E
R
I
A
A
Y
-
Y
-
N
-
H
--
S
I
S
V
L
E
T
G
S
I
I
Q
T
H
T
G
E
G
A
F
A
V
M
V
R
Y
E
---
21
HHSearch
71.97
21%
-79
- C2 -
3JR7
5
?
A:
[20-298]
M
S
Y
K
V
I
V
D
S
C
G
E
F
T
P
E
M
K
A
D
G
G
F
E
H
V
A
L
G
I
Q
I
-
E
D
T
-
Q
W
-
T
D
--
D
-
D
--
S
L
K
Q
E
---
E
L
L
L
K
I
A
E
S
-
T
S
C
--
A
K
T
S
C
P
S
P
E
R
Y
M
E
S
Y
H
C
----
D
A
E
R
-
I
Y
V
V
T
L
S
A
E
L
S
G
S
Y
N
S
A
V
L
G
K
N
L
Y
--
E
E
E
Y
G
E
K
Q
I
H
V
F
N
S
R
S
A
S
V
G
E
T
L
I
A
L
K
V
Q
Q
C
E
K
A
G
-
M
-
T
F
E
E
V
V
E
S
V
E
C
Y
I
E
--
E
--
Q
H
T
Y
F
V
L
E
N
L
D
T
L
R
K
N
G
R
L
T
G
I
K
S
--
A
G
A
L
N
I
K
P
I
M
G
S
T
P
Q
G
T
I
C
Q
K
E
K
A
R
G
M
K
K
A
L
V
---
K
M
A
----
D
C
V
A
A
-
D
--
V
VNA--
G
D
K
I
L
-
A
I
A
---
H
C
N
C
E
E
R
A
K
E
-
V
Q
R
L
L
K
E
R
-
F
-
A
V
K
--
S
S
F
I
V
D
T
S
G
I
S
T
V
Y
A
N
D
G
G
I
I
V
V
V
------
17
HHSearch
71.46
21%
-78
- C2 -
3FDJ
5
?
A:
[3-278]
-
A
M
R
L
V
A
D
S
A
C
D
I
K
E
L
--
R
G
M
V
F
K
A
V
P
L
T
I
S
T
-
D
N
E
-
E
F
-
C
D
--
D
-
G
--
Q
L
D
I
H
---
R
M
L
D
I
L
E
K
H
-
K
G
R
--
S
Y
T
A
C
P
G
I
D
A
W
L
E
A
F
G
D
----
D
D
-
E
-
I
F
V
V
T
I
T
A
G
M
S
G
T
Y
N
S
A
M
A
A
R
A
V
Y
--
L
E
E
H
P
Q
A
K
V
R
V
I
D
S
K
S
T
G
P
Q
M
R
I
I
L
E
Q
L
Q
Q
M
I
E
E
G
-
K
-
K
F
E
E
I
D
G
A
I
D
A
Y
M
Q
--
K
--
T
R
L
F
C
S
L
K
S
L
H
N
L
A
Q
N
G
R
V
S
K
V
V
A
S
A
A
E
V
L
G
I
S
V
I
G
T
A
S
S
H
G
T
L
E
A
I
G
K
C
R
G
D
K
K
L
L
V
---
K
L
Q
----
A
L
L
D
D
-
A
--
G
Y----
E
G
G
K
L
-
R
I
C
---
H
V
E
N
E
A
L
A
D
K
-
I
A
D
M
I
K
Q
A
-
Y
-
G
T
T
--
D
V
C
V
Y
K
A
G
G
L
C
S
Y
Y
A
E
R
G
G
I
I
L
S
C
E
T
K
---
8
PsiBlast_PDB
60.66
29%
-90
- C2 -
3NYI
1
?
A:
[5-197]
--
Y
K
I
V
S
D
S
A
C
D
L
S
K
E
Y
L
E
K
H
D
V
T
I
V
P
L
S
V
S
F
-
D
G
E
-
T
Y
-
Y
R
--
D
-
G
V
D
-
I
T
R
D
---
E
C
Y
Q
R
M
V
-
D
-
D
P
K
L
F
P
K
T
S
L
P
S
V
E
S
Y
A
D
V
F
R
S
F
V
E
Q
G
F
-
P
-
V
V
C
F
T
I
T
T
L
F
S
G
S
Y
N
S
A
I
N
A
K
S
L
V
--
L
E
D
Y
P
D
A
N
I
C
V
I
D
S
K
Q
N
T
V
T
Q
A
L
L
I
D
Q
F
V
R
M
L
E
D
G
-
L
-
S
F
E
Q
A
M
S
K
L
D
A
L
M
A
--
S
--
A
R
I
F
F
T
V
G
S
L
D
Y
L
K
M
G
G
R
I
G
K
V
A
T
A
A
T
G
K
L
G
V
K
P
V
I
I
M
K
D
G
D
I
G
L
G
G
I
G
R
N
R
N
K
L
K
N
S
---
V
L
Q
----
V
A
K
K
Y
-
L
--
D
-----
E
N
N
K
D
-
N
F
I
---
V
S
V
G
Y
G
Y
D
K
E
-
E
G
F
E
F
M
K
E
-
V
-
E
S
T
--
L
D
V
K
L
D
S
E
T
N
V
A
I
G
I
V
S
A
V
H
T
G
P
Y
P
I
G
L
G
V