@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0266: (2015-11-29 )
MTEKYVNKVIVILGASFAGMTCAQKLRQLNPNWDIVLIDKEIHPDYVPNGLNWYYRHEISGLNQAMWQTEEEQRLQNIRCLFGLKVEKINKEDRELMLSDGSSVYYDQLICAMGSQAESTYIDGADAQGVLTTKTYATSQNAKQVLDKSHKVAVVGAGIIGLDIAYSLHESGKAVTLLEAQERPDFRHTDPDMSLPLLDAMAESKLHFFQNQKVEKITVTREEKLCLRTLTGDTFTVDAVILAVNFRPDSRLLTGLVDLSVDNSVVVNDYFQTSDPNIYAIGDLIWSYFKGLNSAYYMPLINQAIRSAQMLAYHLSGHAVPKLKITRATGSKHFGYYRANIGLTELEAGLYEDTVSVTYFPKEQYDLRIKLIANQKTGHLLGAQLISKENCLATANQLVQAISCDMTDFDLAFQDFIYTARESEMAYMLHQAAINLYEKRIGLCE
Atome Classification :
(20 SA)
.........10........20....-....30.......-.40........50........60...-..-...70.....---...80........90......-.---.-----100---...-----..---....110.......120-..-.--.-...130.........-------140....--.--..150---.........160.......170........180.......190.......200..--...-..210-----.....-----....220.------------------....-...230-........240.......250...-.-...260.......270.......280.......290.......300.......310.......-320.......330........340...---------...-.350.......-------360----..--------.--.---------.....--370.......380....---..-.-390.......400.......410.......420.......430.......440...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
E
K
Y
V
N
K
V
I
V
I
LGAS
F
A
G
M
T
C
A
Q
K
-
L
R
QLNPNW
D
I
V
L
I
-DKEIHPDYVPNGL
N
W
Y
Y
R
HEIS
G
L
N
Q
-
A
M
-WQ
T
E
E
E
Q
R
L
Q
---
N
I
R
C
LFG
L
K
V
EKINKE
D
R
E
L
M-L---S-----D-----GS
S
-----
V
Y
---
Y
D
Q
L
I
C
AMGSQAES
T
Y
I-DG-A--D-AQ
G
V
--
L
T
T
K
T
YATS-------
Q
N
A
K
Q
V
L
--D--KSH-----
K
V
A
V
V
G
A
G
I
I
G
L
D
I
A
Y
S
LHE-SG
K
A
V
T
L
L
EAQERPDFRHTDPDMS
L
P
L
L
D
A
M
A
E
S
--
K
L
H
-
F
F
Q-------NQ
K
V
E
-----
K
I
T
VT-RE------------------E
K
L
C
-
L
R
TLT--G
D
T
F
T
V
D
A
V
I
L
A
V
NFRPD
S
R
L
L
T
G
-
L
-
V
DLSVD
N
S
V
V
V
NDYFQTSDP
N
I
Y
A
I
G
D
L
I
W
S
Y
F
K
GLNS
A
Y
Y
M
P
L
I
N
Q
A
I
R
S
A
Q
M
L
A
YHLSGHA-V
P
K
L
K
I
T
RATG-SK
H
F
G
Y
Y
R
ANI
G
L
T
E
---------
L
E
A-GLYED
T
V
S
V
T
Y-------F------PK--------E--Q---------
Y
D
L
R
I
--
K
L
I
ANQKTG
H
L
L
G
A
Q
L
I---SK-E-
N
C
L
A
T
A
N
Q
L
V
Q
A
I
SCDMT
D
F
D
L
A
F
Q
D
F
I
Y
T
A
R
E
S
E
M
A
Y
M
L
H
Q
A
A
I
N
L
Y
E
K
RIGLCE
36
HHSearch
89.04
30%
-101
- C1 -
3OC4
3
?
A:
[3-443]
-------
L
K
I
V
I
I
G
A
S
F
A
G
I
S
A
A
I
A
-
S
R
K
K
Y
P
Q
A
E
I
S
L
I
-
D
K
Q
A
T
V
G
Y
L
S
G
-----------------
R
-
Y
I
T
E
E
E
L
R
R
Q
---
K
I
Q
L
L
L
N
R
E
V
V
A
M
D
V
E
N
Q
L
I
A
-
W
T
R
K
E
-----
E
-----
Q
Q
W
-----
Y
S
---
Y
D
K
L
I
L
A
T
G
A
S
Q
F
S
T
Q
I
-
R
G
-
S
--
Q
-
T
E
K
L
--
L
K
Y
K
F
L
S
-----------
A
V
P
L
L
--
E
--
N
S
Q
-----
T
V
A
V
I
G
A
G
P
I
G
M
E
A
I
D
F
L
V
K
-
M
K
K
T
V
H
V
F
E
S
L
E
N
L
L
P
K
Y
F
D
K
E
M
V
A
E
V
Q
K
S
L
E
K
Q
--
A
V
I
-
F
H
F
-------
E
E
T
V
L
-----
G
I
E
E
T
-
A
N
-------------------
G
I
V
-
L
E
T
S
---
E
Q
E
I
S
C
D
S
G
I
F
A
L
N
L
H
P
Q
L
A
Y
L
D
K
-
K
-
I
Q
R
N
L
D
Q
T
I
A
V
D
A
Y
L
Q
T
S
V
P
N
V
F
A
I
G
D
C
I
S
V
M
N
E
P
V
A
E
T
F
Y
A
P
L
V
N
N
A
V
R
T
G
L
V
V
A
N
N
L
E
E
K
T
-
H
R
F
I
G
S
L
R
T
M
G
-
T
K
V
G
D
Y
Y
L
A
S
T
G
L
T
E
---------
T
E
G
-
L
F
F
P
Q
T
L
A
S
I
I
-------
V
------
R
Q
P
A
PPLQ--
H
--
G
---------
T
E
I
L
G
--
K
L
I
Y
D
K
V
T
Q
R
V
L
G
A
Q
L
C
---
S
K
-
N
N
C
-
L
E
K
I
N
T
L
A
L
S
I
Q
T
G
Q
T
L
T
D
L
L
Q
K
D
Y
F
Y
Q
P
S
L
T
N
I
Y
D
I
T
N
L
M
G
A
S
A
Y
W
R
E
N
D
---
1
PsiBlast_PDB
86.21
32%
-104
- C1 -
3OC4
3
?
A:
[5-420]
---------
I
V
I
I
G
A
S
F
A
G
I
S
A
A
I
A
-
S
R
K
K
Y
P
Q
A
E
I
S
L
I
-
D
K
Q
A
T
V
G
Y
L
S
G
-----------------
R
-
Y
I
T
E
E
E
L
R
R
Q
---
K
I
Q
L
L
L
N
R
E
V
V
A
M
D
V
E
N
Q
L
I
A
-
W
---
T
-----
R
-----
K
E
E
Q
Q
W
--
Y
S
---
Y
D
K
L
I
L
A
T
G
A
S
Q
F
S
T
Q
I
-
R
G
-
S
--
Q
-
T
E
K
L
--
L
K
Y
K
F
L
S
-----------
A
V
P
L
L
--
E
--
N
S
Q
-----
T
V
A
V
I
G
A
G
P
I
G
M
E
A
I
D
F
L
V
K
-
M
K
K
T
V
H
V
F
E
S
L
E
N
L
L
P
K
Y
F
D
K
E
M
V
A
E
V
Q
K
S
L
E
K
Q
--
A
V
I
-
F
H
F
-------
E
E
T
V
L
-----
G
I
E
E
T
-
A
N
-------------------
G
I
V
-
L
E
T
-
S
--
E
Q
E
I
S
C
D
S
G
I
F
A
L
N
L
H
P
Q
L
A
Y
L
D
K
-
K
-
I
Q
R
N
L
D
Q
T
I
A
V
D
A
Y
L
Q
T
S
V
P
N
V
F
A
I
G
D
C
I
S
V
M
N
E
P
V
A
E
T
F
Y
A
P
L
V
N
N
A
V
R
T
G
L
V
V
A
N
N
L
E
E
K
T
-
H
R
F
I
G
S
L
R
T
M
G
-
T
K
V
G
D
Y
Y
L
A
S
T
G
L
T
E
---------
T
E
G
-
L
F
F
P
Q
T
L
A
S
I
I
-------
V
R
Q
P
A
--
P
P
--------
L
--
Q
---------
H
G
T
E
I
L
G
K
L
I
Y
D
K
V
T
Q
R
V
L
G
A
Q
L
C
---
S
K
-
N
-
N
C
L
E
K
I
N
T
L
A
L
S
I
Q
T
G
Q
T
L
T
D
L
L
Q
K
D
Y
F
Y
Q
P
S
L
T
N
I
Y
D
I
T
N
L
M
G
A
S
A
Y
W
R
E
N
D
---
35
HHSearch
79.60
22%
-91
- C1 -
1NHP
3
NAPE_ENTFA
A:
[1-446]
-------
M
K
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
-
L
L
N
L
H
P
D
A
E
I
Q
W
Y
-
E
K
G
D
F
I
S
F
L
S
A
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
-
V
R
-
Y
M
T
G
E
K
M
E
S
R
---
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
-
V
---
K
-----
D
LVSG
E
E
R
V
-----
E
N
---
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
-
P
G
-
K
--
D
-
L
D
N
I
--
Y
L
M
R
G
R
Q
W
A
-------
I
K
L
K
Q
K
T
V
D
P
--
E
V
N
-----
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
-
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
--
N
I
T
-
I
A
T
-------
G
E
T
V
E
-----
R
Y
E
G
D
-
G
--------------------
R
V
Q
K
V
V
T
D
---
K
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
-
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
V
-
K
P
F
P
G
V
Q
G
S
S
G
-
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
---------
V
M
A
-
Q
K
L
G
K
E
T
K
A
V
T
-------
V
V
E
DYLM
D
F
NP------
D
--
K
---------
Q
K
A
W
F
--
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
---
S
K
A
D
-
L
-
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
R
----
3
PsiBlast_PDB
78.57
23%
-92
- C1 -
1JOA
1
NAPE_ENTFA
A:
[3-440]
---------
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
-
L
L
N
L
H
P
D
A
E
I
Q
W
Y
-
E
K
G
D
F
I
S
F
L
S
C
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
-
V
R
-
Y
M
T
G
E
K
M
E
S
R
---
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
-
V
---
K
-----
D
-----
L
V
S
G
E
E
R
V
E
N
---
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
-
P
G
-
K
--
D
-
L
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
-------
L
K
Q
K
T
V
D
--
P
--
E
V
N
-----
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
-
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
--
N
I
T
-
I
A
T
-------
G
E
T
V
E
-----
R
Y
E
G
D
G
R
V
------------------
Q
K
V
V
-
T
D
K
-----
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
-
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
V
-
K
P
F
P
G
V
Q
G
S
S
G
-
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
---------
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
EDYLMD
F
------
N
P
--------
D
--
K
---------
Q
K
A
W
F
--
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
---
S
K
-
A
-
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
R
----
42
HHSearch
78.55
25%
-95
- C1 -
3ICS
4
?
A:
[34-486]
----
W
G
S
R
K
I
V
V
V
G
G
V
A
G
G
A
S
V
A
A
R
-
L
R
R
L
S
E
E
D
E
I
I
M
V
-
E
R
G
E
Y
I
S
F
A
N
C
G
L
P
Y
Y
I
G
G
V
I
T
E
R
Q
K
L
L
V
-
Q
T
V
E
R
M
S
K
R
F
---
N
L
D
I
R
V
L
S
E
V
V
K
I
N
K
E
E
K
T
I
T
-
I
---
K
-----
N
VTTN
E
T
Y
N
-----
E
A
---
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
P
S
I
-
P
G
-
I
--
E
E
A
K
A
L
--
F
T
L
R
N
V
P
D
T
-------
D
R
I
K
A
Y
I
--
D
E
K
K
P
R
-----
H
A
T
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
R
E
-
R
G
I
E
V
T
L
V
E
M
A
N
Q
V
M
P
-
P
I
D
Y
E
M
A
A
Y
V
H
E
H
M
K
N
H
--
D
V
E
-
L
V
F
-------
E
D
G
V
D
-----
A
L
E
E
N
-
G
--------------------
A
V
V
-
R
L
K
S
---
G
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
K
G
A
G
-
L
A
L
G
V
R
G
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
V
T
E
T
E
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
T
D
S
L
Y
K
G
T
L
G
T
S
V
-
A
K
V
F
D
L
T
V
A
T
T
G
L
N
E
---------
K
I
L
-
K
R
L
N
I
P
Y
E
V
V
H
-------
V
------
Q
A
N
SHAGY--
Y
PN
A
---------
T
P
V
L
I
--
K
L
I
F
N
K
D
S
G
K
I
Y
G
A
Q
T
L
---
G
R
-
D
-
G
V
D
K
R
M
D
V
I
A
T
A
I
K
A
N
L
T
V
L
D
L
P
D
L
E
L
S
Y
A
P
P
Y
S
S
A
K
D
P
V
N
M
V
G
Y
A
A
S
N
I
V
D
G
F
V
D
2
PsiBlast_PDB
77.35
23%
-90
- C1 -
1NHQ
2
NAPE_ENTFA
A:
[3-440]
---------
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
-
L
L
N
L
H
P
D
A
E
I
Q
W
Y
-
E
K
G
D
F
I
S
F
L
S
S
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
-
V
R
-
Y
M
T
G
E
K
M
E
S
R
---
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
-
V
---
K
-----
D
-----
L
V
S
G
E
E
R
V
E
N
---
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
-
P
G
-
K
--
D
-
L
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
-------
L
K
Q
K
T
V
D
--
P
--
E
V
N
-----
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
-
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
--
N
I
T
-
I
A
T
-------
G
E
T
V
E
-----
R
Y
E
G
D
G
R
V
------------------
Q
K
V
V
-
T
D
K
-----
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
-
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
V
-
K
P
F
P
G
V
Q
G
S
S
G
-
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
---------
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
DYLMD
F
------
N
P
--------
D
--
K
---------
Q
K
A
W
F
--
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
---
S
K
-
A
-
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
R
----
6
PsiBlast_PDB
77.28
23%
-90
- C1 -
1NHP
3
NAPE_ENTFA
A:
[3-440]
---------
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
-
L
L
N
L
H
P
D
A
E
I
Q
W
Y
-
E
K
G
D
F
I
S
F
L
S
A
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
-
V
R
-
Y
M
T
G
E
K
M
E
S
R
---
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
-
V
---
K
-----
D
-----
L
V
S
G
E
E
R
V
E
N
---
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
-
P
G
-
K
--
D
-
L
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
-------
L
K
Q
K
T
V
D
--
P
--
E
V
N
-----
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
-
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
--
N
I
T
-
I
A
T
-------
G
E
T
V
E
-----
R
Y
E
G
D
G
R
V
------------------
Q
K
V
V
-
T
D
K
-----
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
-
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
V
-
K
P
F
P
G
V
Q
G
S
S
G
-
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
---------
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
DYLMD
F
------
N
P
--------
D
--
K
---------
Q
K
A
W
F
--
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
---
S
K
-
A
-
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
R
----
4
PsiBlast_PDB
76.93
23%
-90
- C1 -
1NPX
2
NAPE_ENTFA
A:
[3-440]
---------
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
-
L
L
N
L
H
P
D
A
E
I
Q
W
Y
-
E
K
G
D
F
I
S
F
L
S
C
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
-
V
R
-
Y
M
T
G
E
K
M
E
S
R
---
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
-
V
---
K
-----
D
-----
L
V
S
G
E
E
R
V
E
N
---
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
-
P
G
-
K
--
D
-
L
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
-------
L
K
Q
K
T
V
D
--
P
--
E
V
N
-----
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
-
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
--
N
I
T
-
I
A
T
-------
G
E
T
V
E
-----
R
Y
E
G
D
G
R
V
------------------
Q
K
V
V
-
T
D
K
-----
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
-
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
V
-
K
P
F
P
G
V
Q
G
S
S
G
-
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
---------
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
DYLMD
F
------
N
P
--------
D
--
K
---------
Q
K
A
W
F
--
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
---
S
K
-
A
-
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
R
----
8
PsiBlast_PDB
76.83
23%
-91
- C1 -
1NHR
3
NAPE_ENTFA
A:
[3-440]
---------
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
-
L
L
N
L
H
P
D
A
E
I
Q
W
Y
-
E
K
G
D
F
I
S
F
C
S
C
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
-
V
R
-
Y
M
T
G
E
K
M
E
S
R
---
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
-
V
---
K
-----
D
-----
L
V
S
G
E
E
R
V
E
N
---
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
-
P
G
-
K
--
D
-
L
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
-------
L
K
Q
K
T
V
D
--
P
--
E
V
N
-----
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
-
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
--
N
I
T
-
I
A
T
-------
G
E
T
V
E
-----
R
Y
E
G
D
G
R
V
------------------
Q
K
V
V
-
T
D
K
-----
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
-
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
V
-
K
P
F
P
G
V
Q
G
S
S
G
-
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
---------
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
DYLMD
F
------
N
P
--------
D
--
K
---------
Q
K
A
W
F
--
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
---
S
K
-
A
-
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
R
----
41
HHSearch
76.54
21%
-91
* C1 *
3NTD
4
?
A:
[1-467]
------
M
K
K
I
L
I
I
G
G
V
A
G
G
A
S
A
A
A
R
-
A
R
R
L
S
E
T
A
E
I
I
M
F
-
E
R
G
E
Y
V
S
F
A
N
C
G
L
P
Y
H
I
S
G
E
I
A
Q
R
S
A
-
L
V
L
Q
T
P
E
S
F
K
A
R
F
---
N
V
E
V
R
V
K
H
E
V
V
A
I
D
R
A
A
K
L
V
T
-
V
---
R
RLLDG
S
-----
E
Y
Q
-----
E
S
---
Y
D
T
L
L
L
S
P
G
A
A
P
I
V
P
P
I
-
P
G
-
V
--
D
-
N
P
L
T
--
H
S
L
R
N
I
P
D
M
-------
D
R
I
L
Q
T
I
--
Q
MN
N
V
E
-----
H
A
T
V
V
G
G
G
F
I
G
L
E
M
M
E
S
L
H
H
-
L
G
I
K
T
T
L
L
E
L
A
D
Q
V
M
T
-
P
V
D
R
E
M
A
G
F
A
H
Q
A
I
R
D
Q
--
G
V
D
-
L
R
L
-------
G
T
A
L
S
-----
E
V
S
Y
Q
-
V
Q
T
H
V
A
S
DAAGEDTAHQHIK
G
H
L
S
L
T
L
S
N
---
G
E
L
L
E
T
D
L
L
I
M
A
I
G
V
R
P
E
T
Q
L
A
R
D
A
G
-
L
A
I
G
E
L
G
G
I
K
V
N
A
M
M
Q
T
S
D
P
A
I
Y
A
V
G
D
A
V
E
E
Q
D
F
V
T
G
Q
A
C
L
V
P
L
A
G
P
A
N
R
Q
G
R
M
A
A
D
N
M
F
G
R
E
-
E
R
Y
Q
G
T
Q
G
T
A
I
-
C
K
V
F
D
L
A
V
G
A
T
G
K
N
E
---------
K
Q
L
-
K
Q
A
G
I
A
F
E
K
V
Y
-------
V
------
H
T
ASHASY--
Y
PG
A
---------
E
V
V
S
F
--
K
L
L
F
D
P
V
K
G
T
I
F
G
A
Q
A
V
---
G
K
-
D
-
G
I
D
K
R
I
D
V
M
A
V
A
Q
R
A
G
M
T
V
E
Q
L
Q
H
L
E
L
S
Y
A
P
P
Y
G
S
A
K
D
V
I
N
Q
A
A
F
V
A
S
N
I
I
K
G
D
A
T
7
PsiBlast_PDB
76.18
23%
-91
- C1 -
1NHS
3
NAPE_ENTFA
A:
[3-440]
---------
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
-
L
L
N
L
H
P
D
A
E
I
Q
W
Y
-
E
K
G
D
F
I
S
F
L
C
C
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
-
V
R
-
Y
M
T
G
E
K
M
E
S
R
---
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
-
V
---
K
-----
D
-----
L
V
S
G
E
E
R
V
E
N
---
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
-
P
G
-
K
--
D
-
L
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
-------
L
K
Q
K
T
V
D
--
P
--
E
V
N
-----
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
-
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
--
N
I
T
-
I
A
T
-------
G
E
T
V
E
-----
R
Y
E
G
D
G
R
V
------------------
Q
K
V
V
-
T
D
K
-----
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
-
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
V
-
K
P
F
P
G
V
Q
G
S
S
G
-
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
---------
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
DYLMD
F
------
N
P
--------
D
--
K
---------
Q
K
A
W
F
--
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
---
S
K
-
A
-
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
R
----
5
PsiBlast_PDB
76.18
23%
-91
- C1 -
2NPX
3
NAPE_ENTFA
A:
[3-440]
---------
V
I
V
L
G
S
S
H
G
G
Y
E
A
V
E
E
-
L
L
N
L
H
P
D
A
E
I
Q
W
Y
-
E
K
G
D
F
I
S
F
L
S
C
G
M
Q
L
Y
L
E
G
K
V
K
D
V
N
S
-
V
R
-
Y
M
T
G
E
K
M
E
S
R
---
G
V
N
V
F
S
N
T
E
I
T
A
I
Q
P
K
E
H
Q
V
T
-
V
---
K
-----
D
-----
L
V
S
G
E
E
R
V
E
N
---
Y
D
K
L
I
I
S
P
G
A
V
P
F
E
L
D
I
-
P
G
-
K
--
D
-
L
D
N
I
Y
L
M
R
G
R
Q
W
A
I
K
-------
L
K
Q
K
T
V
D
--
P
--
E
V
N
-----
N
V
V
V
I
G
S
G
Y
I
G
I
E
A
A
E
A
F
A
K
-
A
G
K
K
V
T
V
I
D
I
L
D
R
P
L
G
V
Y
L
D
K
E
F
T
D
V
L
T
E
E
M
E
A
N
--
N
I
T
-
I
A
T
-------
G
E
T
V
E
-----
R
Y
E
G
D
G
R
V
------------------
Q
K
V
V
-
T
D
K
-----
N
A
Y
D
A
D
L
V
V
V
A
V
G
V
R
P
N
T
A
W
L
K
G
-
T
-
L
E
L
H
P
N
G
L
I
K
T
D
E
Y
M
R
T
S
E
P
D
V
F
A
V
G
D
A
T
L
I
K
Y
N
P
A
D
T
E
V
N
I
A
L
A
T
N
A
R
K
Q
G
R
F
A
V
K
N
L
E
E
P
V
-
K
P
F
P
G
V
Q
G
S
S
G
-
L
A
V
F
D
Y
K
F
A
S
T
G
I
N
E
---------
V
M
A
Q
K
L
G
K
E
T
K
A
V
T
V
V
E
DYLMD
F
------
N
P
--------
D
--
K
---------
Q
K
A
W
F
--
K
L
V
Y
D
P
E
T
T
Q
I
L
G
A
Q
L
M
---
S
K
-
A
-
D
L
T
A
N
I
N
A
I
S
L
A
I
Q
A
K
M
T
I
E
D
L
A
Y
A
D
F
F
F
Q
P
A
F
D
K
P
W
N
I
I
N
T
A
A
L
E
A
V
K
Q
E
R
----
14
PsiBlast_PDB
74.21
26%
-112
- C1 -
1Q1R
1
CAMA_PSEPU
A:
[4-338]
------
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
-
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
-
L
S
K
A
Y
L
A
G
K
A
T
A
E
S
-
L
Y
-
L
R
T
P
D
A
Y
A
A
Q
---
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
-
L
---
S
-----
D
-----
G
R
A
-----
L
D
---
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
P
V
A
S
G
-
A
VG
K
-
A
N
N
F
--
R
Y
L
R
T
L
E
D
A
-------
E
C
I
R
R
Q
L
--
I
--
A
D
N
-----
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
-
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
--
G
V
D
-
I
R
T
-------
G
T
Q
V
C
-----
G
F
E
M
S
-
T
D
------------------
Q
Q
K
V
-
T
A
V
L
C
ED
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
---
A
G
L
Q
V
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
L
Y
D
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
-------
K
V
P
R
D
E
A
-
A
P
W
F
W
S
D
Q
Y
E
I
G
L
K
M
---------
V
G
L
-
S
E
G
Y
D
R
I
I
V
R
G
-------
S
------
L
A
--------
Q
--
P
---------
D
F
S
V
F
--
Y
L
Q
G
D
R
V
L
A
V
D
T
V
N
R
P
V
---
E
F
-
N
-
Q
S
K
Q
I
I
T
D
R
L
P
V
E
P
N
L
L
G
D
E
S
V
P
L
K
E
I
I
A
A
A
K
A
E
L
S
S
A
------------------
38
HHSearch
73.54
21%
-89
- C1 -
3IWA
1
?
A:
[4-462]
-------
K
H
V
V
V
I
G
A
V
A
L
G
P
K
A
A
C
R
-
F
K
R
L
D
P
E
A
H
V
T
M
I
-
D
Q
A
-----------------------------------------
V
E
A
L
V
E
T
R
A
H
A
I
D
R
A
A
H
T
V
E
-
I
---
E
-----
N
LRTG
E
R
R
T
-----
L
K
---
Y
D
K
L
V
L
A
L
G
S
K
A
N
R
P
P
V
-
E
G
-
M
--
D
-
L
A
G
V
--
T
P
V
T
N
L
D
E
A
-------
E
F
V
Q
H
A
I
--
S
AG
E
V
S
-----
K
A
V
I
V
G
G
G
F
I
G
L
E
M
A
V
S
L
A
D
M
W
G
I
D
T
T
V
V
E
L
A
D
Q
I
M
P
G
F
T
S
K
S
L
S
Q
M
L
R
H
D
L
E
K
N
--
D
V
V
-
V
H
T
-------
G
E
K
V
V
-----
R
L
E
G
E
-
N
G
-------------------
K
V
A
R
V
I
T
D
---
K
R
T
L
D
A
D
L
V
I
L
A
A
G
V
S
P
N
T
Q
L
A
R
D
A
G
-
L
E
L
D
P
R
G
A
I
I
V
D
T
R
M
R
T
S
D
P
D
I
F
A
G
G
D
C
V
T
I
P
N
L
V
T
G
K
P
G
F
F
P
L
G
S
M
A
N
R
Q
G
R
V
I
G
T
N
L
A
D
G
D
-
A
T
F
P
G
A
V
G
S
W
A
-
V
K
L
F
E
G
S
A
S
G
A
G
L
T
V
---------
E
G
A
-
L
R
E
G
Y
D
A
V
N
V
H
-------
V
------
E
Q
----------------------
I
M
T
L
--
Q
L
V
V
D
R
P
T
R
R
V
L
G
I
Q
G
F
S
TL
G
D
-
A
-
L
-
T
A
R
I
N
A
V
A
T
M
L
A
S
K
P
T
V
E
D
I
S
N
A
E
V
V
--------
M
D
I
V
N
V
A
G
N
V
A
D
N
V
L
A
----
10
PsiBlast_PDB
72.21
26%
-90
- C1 -
2BCP
4
NAOX_STRP6
A:
[38-470]
---------
I
V
V
V
G
A
N
H
A
G
T
A
C
I
K
T
M
L
T
N
Y
G
D
A
N
E
I
V
V
F
-
D
Q
N
S
N
I
S
F
L
G
S
G
M
A
L
W
I
G
E
Q
I
A
G
P
E
G
-
L
F
-
Y
S
D
K
E
E
L
E
S
L
---
G
A
K
V
Y
M
E
S
P
V
Q
S
I
D
Y
D
A
K
T
V
T
A
L
---
V
-----
D
-----
G
K
N
H
V
---
E
T
---
Y
D
K
L
I
F
A
T
G
S
Q
P
I
L
P
P
I
-
K
G
-
A
--
E
I
K
E
G
S
--
L
E
F
E
A
T
L
E
N
LQFVKL
Y
Q
N
S
A
D
V
I
--
A
--
K
L
E
NKDIK
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
A
E
A
F
Q
R
-
K
G
K
E
V
V
L
I
D
V
V
D
T
C
L
A
G
Y
Y
D
R
D
L
T
D
L
M
A
K
N
M
E
E
H
GI
Q
L
A
-
F
G
E
TVK
E
V
A
G
N
G
K
V
E
-----
K
I
I
T
D
-
K
N
------------------
E
--------------
Y
D
V
D
M
V
I
L
A
V
G
F
R
P
N
T
T
L
G
N
G
-
K
-
I
D
L
F
R
N
G
A
F
L
V
N
K
R
Q
E
T
S
I
P
G
V
Y
A
I
G
D
C
A
T
I
Y
D
N
A
T
R
D
T
N
Y
I
A
L
A
S
N
A
V
R
T
G
I
V
A
A
H
N
A
C
G
T
D
-
L
E
G
I
G
V
Q
G
S
N
G
-
I
S
I
Y
G
L
H
M
V
S
T
G
L
T
L
---------
E
K
A
-
K
R
L
G
F
D
A
A
V
T
E
-------
Y
------
T
D
--------
N
--
Q
KPEFIEHG
N
F
P
V
T
I
--
K
I
V
Y
D
K
D
S
R
R
I
L
G
A
Q
M
A
---
A
R
-
E
-
D
V
S
M
G
I
H
M
F
S
L
A
I
Q
E
G
V
T
I
E
K
L
A
L
T
D
I
F
F
L
P
H
F
N
K
P
Y
N
Y
I
T
M
A
A
L
G
A
K
D
-------
15
PsiBlast_PDB
72.03
26%
-112
- C1 -
1Q1W
1
CAMA_PSEPU
A:
[4-338]
------
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
-
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
-
L
S
K
A
Y
L
A
G
K
A
T
A
E
S
-
L
Y
-
L
R
T
P
D
A
Y
A
A
Q
---
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
-
L
---
S
-----
D
-----
G
R
A
-----
L
D
---
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
P
V
A
S
G
-
A
VG
K
-
A
N
N
F
--
R
Y
L
R
T
L
E
D
A
-------
E
C
I
R
R
Q
L
--
I
--
A
D
N
-----
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
-
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
--
G
V
D
-
I
R
T
-------
G
T
Q
V
C
-----
G
F
E
M
S
-
T
D
------------------
Q
Q
K
V
-
T
A
V
L
C
ED
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
---
A
G
L
Q
V
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
L
Y
D
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
-------
K
V
P
R
D
E
A
-
A
P
W
F
W
S
D
Q
Y
E
I
G
L
K
M
---------
V
G
L
-
S
E
G
Y
D
R
I
I
V
R
G
-------
S
------
L
A
--------
Q
--
P
---------
D
F
S
V
F
--
Y
L
Q
G
D
R
V
L
A
V
D
T
V
N
R
P
V
---
E
F
-
N
-
Q
S
K
Q
I
I
T
D
R
L
P
V
E
P
N
L
L
G
D
E
S
V
P
L
K
E
I
I
A
A
A
K
A
E
L
S
S
A
P
-----------------
40
HHSearch
71.93
22%
-97
- C1 -
3CGB
4
?
A:
[37-478]
-------
M
N
Y
V
I
I
G
G
D
A
A
G
M
S
A
A
M
Q
-
I
V
R
N
D
E
N
A
N
V
V
T
L
-
E
K
G
E
I
Y
S
Y
A
Q
C
G
L
P
Y
V
I
S
G
A
I
A
S
T
E
K
L
I
A
-
R
N
V
K
T
F
R
D
K
Y
---
G
I
D
A
K
V
R
H
E
V
T
K
V
D
T
E
K
K
I
V
Y
-
A
---
E
HTKTK
D
-----
V
F
E
-----
F
S
---
Y
D
R
L
L
I
A
T
G
V
R
P
V
M
P
E
W
-
E
G
-
R
--
D
-
L
Q
G
V
--
H
L
L
K
T
I
P
D
A
-------
E
R
I
L
K
T
L
--
E
TN
K
V
E
-----
D
V
T
I
I
G
G
G
A
I
G
L
E
M
A
E
T
F
V
E
-
L
G
K
K
V
R
M
I
E
R
N
D
H
I
G
T
-
I
Y
D
G
D
M
A
E
Y
I
Y
K
E
A
D
K
H
--
H
I
E
-
I
L
T
-------
N
E
N
V
K
-----
A
F
K
G
N
-
E
--------------------
R
V
E
A
V
E
T
D
---
K
G
T
Y
K
A
D
L
V
L
V
S
V
G
V
K
P
N
T
D
F
L
E
G
T
N
-
I
R
T
N
H
K
G
A
I
E
V
N
A
Y
M
Q
T
N
V
Q
D
V
Y
A
A
G
D
C
A
T
H
Y
H
V
I
K
E
I
H
D
H
I
P
I
G
T
T
A
N
K
Q
G
R
L
A
G
L
N
M
L
D
K
R
-
R
A
F
K
G
T
L
G
T
G
I
-
I
K
F
M
N
L
T
L
A
R
T
G
L
N
E
---------
K
E
A
-
K
G
L
H
I
P
Y
K
T
V
K
-------
V
------
D
S
TNMAGYYP
N
--
A
---------
K
P
L
Y
L
--
K
L
L
Y
R
S
D
T
K
Q
L
L
G
G
Q
V
I
---
G
E
-
E
-
G
V
D
K
R
I
D
V
I
A
M
A
L
F
N
K
M
S
I
H
D
L
E
D
V
D
L
S
Y
A
P
P
Y
N
S
V
W
D
P
I
Q
Q
A
A
R
R
A
E
--------
16
PsiBlast_PDB
71.76
26%
-111
- C1 -
3LB8
1
CAMA_PSEPU
A:
[3-337]
------
N
D
N
V
V
I
V
G
T
G
L
A
G
V
E
V
A
F
G
-
L
R
A
S
G
W
E
G
N
I
R
L
V
G
D
A
T
V
I
P
H
H
L
P
P
-
L
S
K
A
Y
L
A
G
K
A
T
A
E
S
-
L
Y
-
L
R
T
P
D
A
Y
A
A
Q
---
N
I
Q
L
L
G
G
T
Q
V
T
A
I
N
R
D
R
Q
Q
V
I
-
L
---
S
-----
D
-----
G
R
A
-----
L
D
---
Y
D
R
L
V
L
A
T
G
G
R
P
R
P
L
P
V
A
S
G
-
A
VG
K
-
A
N
N
F
--
R
Y
L
R
T
L
E
D
A
-------
E
C
I
R
R
Q
L
--
I
--
A
D
N
-----
R
L
V
V
I
G
G
G
Y
I
G
L
E
V
A
A
T
A
I
K
-
A
N
M
H
V
T
L
L
D
T
A
A
R
V
L
E
R
V
T
A
P
P
V
S
A
F
Y
E
H
L
H
R
E
A
--
G
V
D
-
I
R
T
-------
G
T
Q
V
C
-----
G
F
E
M
S
-
T
D
------------------
Q
Q
K
V
-
T
A
V
L
C
ED
G
T
R
L
P
A
D
L
V
I
A
G
I
G
L
I
P
N
C
E
L
A
S
A
---
A
G
L
Q
V
D
N
G
I
V
I
N
E
H
M
Q
T
S
D
P
L
I
M
A
V
G
D
C
A
R
F
H
S
Q
L
Y
D
R
W
V
R
I
E
S
V
P
N
A
L
E
Q
A
R
K
I
A
A
I
L
C
G
-------
K
V
P
R
D
E
A
-
A
P
W
F
W
S
D
Q
Y
E
I
G
L
K
M
---------
V
G
L
-
S
E
G
Y
D
R
I
I
V
R
G
-------
S
------
L
A
--------
Q
--
P
---------
D
F
S
V
F
--
Y
L
Q
G
D
R
V
L
A
V
D
T
V
N
R
P
V
---
E
F
-
N
-
Q
S
K
Q
I
I
T
D
R
L
P
V
E
P
N
L
L
G
D
E
S
V
P
L
K
E
I
I
A
A
A
K
A
E
L
S
--------------------
13
PsiBlast_PDB
70.68
27%
-90
- C1 -
3ICT
4
?
A:
[54-462]
------------------------
R
-
L
R
R
L
S
E
E
D
E
I
I
M
V
-
E
R
G
E
Y
I
S
F
A
N
C
G
L
P
Y
Y
I
G
G
V
I
T
E
R
Q
K
-
L
L
-
V
Q
T
V
E
R
M
S
K
R
F
NL
D
I
R
V
L
S
--
E
V
V
K
I
N
K
E
E
K
T
I
T
-
I
---
K
-----
N
-----
V
T
T
N
E
---
T
Y
N
E
A
Y
D
V
L
I
L
S
P
G
A
K
P
I
V
P
S
I
-
P
G
I
E
--
E
-
A
K
A
L
--
F
T
L
R
N
V
P
D
T
-------
D
R
I
K
A
Y
I
--
D
E
K
K
P
R
-----
H
A
T
V
I
G
G
G
F
I
G
V
E
M
V
E
N
L
R
E
-
R
G
I
E
V
T
L
V
E
M
A
----------
N
Q
V
M
P
P
I
D
Y
E
M
A
A
--
Y
V
H
E
H
M
K
-------
N
H
D
V
E
L
V
F
ED
G
V
D
A
L
-
E
E
------------------
N
G
A
V
-
V
R
L
K
S
--
G
S
V
I
Q
T
D
M
L
I
L
A
I
G
V
Q
P
E
S
S
L
A
K
G
-
A
G
L
A
L
G
V
R
G
T
I
K
V
N
E
K
F
Q
T
S
D
P
H
I
Y
A
I
G
D
A
I
E
V
K
D
F
V
T
E
T
E
T
M
I
P
L
A
W
P
A
N
R
Q
G
R
M
L
A
D
I
I
H
G
H
T
-
D
S
L
Y
K
G
T
L
G
T
S
V
A
K
V
F
D
L
T
V
A
T
T
G
L
N
E
K
I
L
K
R
L
N
I
P
Y
E
V
-
V
H
V
Q
A
N
S
H
A
G
Y
-------
Y
------
P
N
--------
A
--
T
---------
P
V
L
-
I
--
K
L
I
F
N
K
D
S
G
K
I
Y
G
A
Q
T
L
---
G
R
-
D
-
G
V
D
K
R
M
D
V
I
A
T
A
I
K
A
N
L
T
V
L
D
L
P
D
L
E
L
S
Y
A
P
P
Y
S
S
A
K
D
P
V
N
M
V
G
Y
A
A
S
N
I
V
D
G
F
V
D
9
PsiBlast_PDB
70.59
26%
-86
- C1 -
2BC1
2
NAOX_STRP6
A:
[38-470]
---------
I
V
V
V
G
A
N
H
A
G
T
A
C
I
K
T
M
L
T
N
Y
G
D
A
N
E
I
V
V
F
-
D
Q
N
S
N
I
S
F
L
G
S
G
M
A
L
W
I
G
E
Q
I
A
G
P
E
G
-
L
F
-
Y
S
D
K
E
E
L
E
S
L
---
G
A
K
V
Y
M
E
S
P
V
Q
S
I
D
Y
D
A
K
T
V
T
A
L
---
V
-----
D
-----
G
K
N
H
V
---
E
T
---
Y
D
K
L
I
F
A
T
G
S
Q
P
I
L
P
P
I
-
K
G
-
A
--
E
I
K
E
G
S
--
L
E
F
E
A
T
L
E
N
L
Q
F
V
KL
Y
Q
N
S
A
D
V
I
--
A
--
K
L
E
NKDIK
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
A
E
A
F
Q
R
-
K
G
K
E
V
V
L
I
D
V
V
D
T
C
L
A
G
Y
Y
D
R
D
L
T
D
L
M
A
K
N
M
E
E
H
G
I
Q
L
A
-
F
G
E
TVKEVAG
N
G
K
V
E
-----
K
I
I
T
D
-
K
N
------------------
E
--------------
Y
D
V
D
M
V
I
L
A
V
G
F
R
P
N
T
T
L
G
N
G
-
K
-
I
D
L
F
R
N
G
A
F
L
V
N
K
R
Q
E
T
S
I
P
G
V
Y
A
I
G
D
C
A
T
I
Y
D
N
A
T
R
D
T
N
Y
I
A
L
A
S
N
A
V
R
T
G
I
V
A
A
H
N
A
C
G
T
D
-
L
E
G
I
G
V
Q
G
S
N
G
-
I
S
I
Y
G
L
H
M
V
S
T
G
L
T
L
---------
E
K
A
-
K
R
L
G
F
D
A
A
V
T
E
-------
Y
------
T
D
--------
N
--
Q
KPEFIEHG
N
F
P
V
T
I
--
K
I
V
Y
D
K
D
S
R
R
I
L
G
A
Q
M
A
---
A
R
-
E
-
D
V
S
M
G
I
H
M
F
S
L
A
I
Q
E
G
V
T
I
E
K
L
A
L
T
D
I
F
F
L
P
H
F
N
K
P
Y
N
Y
I
T
M
A
A
L
G
A
K
D
-------