@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0277: (2015-11-29 )
MTFFKKLKKIFLDYVIHIRDRRSPQKNRERVGQNLMILTIFLFFIFIINFVIIVGTDSKFGVNLSKEAKKVYQQSMTVQAKRGTIYDRNGNPIAEDATTYSLYAIISKNYTTATGQKLYVQPSQYEKVASILENKLGMKKNLVLKQLNQKKLFQVSFGSSGSGLSYTKMADIKKTMEKSDIKGIGFSTSPGRIYPNGIFASQFIGFTLPQDDGDGKKLVGNTGLEAALNKVLSGTDGKVTYEKDRSGNVLLGTATTERRAVNGKDIYTTLSEPIQTVLETQMDVFAEKTKGKFASATVVNAKTGEILATSQRPTYNPSTLKGYDKKNLGTYNTLLYDNFFEPGSTMKVMTLASAIDSKHFNSTEVYNSAQYKIADAVIRDWDVNEGLSSGSYMTFPQGFAHSSNVGMVTLEQKMGRDKWLNYLSKFKFGYPTRFGMLHESGGLFPSDNEVTIAMSSFGQGIGVTQVQMLRAFTSISNDGVMLQPQFISSIYDPNTGTSRTARKEVVGKPISKEAASKTRDYMVTVGTDPYYGTLYAAGAPVIQVGNQSVAVKSGTAQIAQEGGGGYLQGKNDTINSVVAMVPSENPDFIMYVTIQQPEKFSITFWKDVVNPVLEQATAMKETILKPGLNDSEHQTKYKLSKIVGENPGHVAEELRRNLVQPIILGNGSKVSKVSKRPGANLAENEQLLVLTNKLTELPDMYGWSKANVEQFAKWTGIKVTYKGSTSGKVRKQSIDVGKSINKIKKIKITIGD
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210..-.-..-..220.......230.......240.......250..-.....260........270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......--370.......380..---.....390.......400........410.......420.......430.......440.....---.---.---450.......460.......470.......480.......490.......500.......510..-.....520.......530...--..--.------.540........550.......560.......570.......580.......590.....--..---600.......610.......620-...----......630.......640.......650.......660.......670.......680.......690.......700.......710.......720..-.....730.......740.......750
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
F
F
K
K
L
K
K
I
F
L
D
Y
V
I
H
IRDRRSP
Q
K
N
R
E
R
VGQ
N
L
M
I
L
T
I
F
L
F
F
I
F
I
I
N
F
V
I
I
V
GTDSKFGVN
L
S
K
E
A
K
K
V
Y
Q
Q
S
M
T
V
Q
AKR
G
T
I
YDRNGNPIAEDAT
T
Y
S
L
Y
A
I
I
SKNYTTATG
Q
K
L
Y
VQ
P
S
Q
Y
E
K
V
A
S
I
L
E
N
K
LGM
K
K
N
L
V
L
K
QLNQK
K
L
F
Q
V
SFGSSGSGLS
Y
T
K
M
A
D
I
K
K
T
M
E
KSDIKGIGFSTSPG
R
I
YPNGI
F
A
S
QFI
G
F
TLPQDDGD-G-
K
K
-
L
VGNT
G
L
E
A
A
L
N
K
V
LSGTDG
K
V
T
Y
E
KDRSG
N
V
L
L
G
TA-TTERRAV-NG
K
D
I
Y
T
T
L
S
E
P
I
Q
T
V
L
E
T
Q
M
D
V
F
A
E
KTKGKFA
S
A
T
V
V
NAKT
G
E
I
L
ATSQRPTYN
P
S
TLKGYDKKNLGT
Y
N
T
L
L
Y
DNFFEPGS
T
M
K
V
M
T
L
A
S
A
IDSKHFNSTEVYNSA--Q
Y
K
I
A
D
A
V
IRDWDVN---EGLSSGS
Y
M
TFPQGFAH-SSNV
G
M
V
T
L
E
Q
KM
G
R
D
K
W
L
N
Y
L
S
K
FKFGYPTRF
G
M
L
HESGGLFPSD---
N
---
E
---
V
T
I
A
M
S
SFGQGI
G
V
T
Q
V
Q
M
L
R
A
F
T
SISND
G
V
M
L
Q
P
Q
F
I
S
S
IYDPNTGTS
R
T
A
R
K
E
V
VGKPI
S
K
E
A
-ASKTR
D
Y
M
V
T
VGTDPY
Y
G
T
L
Y--AA--G------A
P
V
-
I
Q
VGN
Q
S
V
A
VKSG
T
A
Q
I
A
Q
EGGGGYLQGKND
T
I
N
S
V
V
AMVPSENP
D
F
I
M
Y
V
T
IQQP--E
K
---
F
S
I
T
F
W
K
D
V
V
N
P
V
L
E
Q
A
T
A
M
K
---
E
T
I
----LKPGLND
S
E
H
Q
T
K
Y
K
L
S
K
I
VGENP
G
H
V
A
E
E
L
R
R
NLVQ
P
I
I
LGNGSKV
S
K
VSKRPGANLAEN
E
Q
L
L
V
L
T
N
K
L
TELPDMYGW
S
K
A
N
V
E
Q
F
AKWT
G
I
K
V
T
Y
KGS-TSG
K
V
R
K
QSIDVGKSIN
K
I
K
K
I
K
I
T
IGD
1
PsiBlast_PDB
91.13
55%
-61
- C1 -
1RP5
1
PBPX_STRPN
A:
[16-702]
---------------------------------------------------------------------
K
V
H
Q
T
T
R
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
V
I
D
E
N
Y
K
S
A
T
G
K
I
L
Y
V
E
K
T
Q
F
N
K
V
A
E
V
F
H
K
Y
L
D
M
E
E
S
Y
V
R
E
Q
L
S
Q
P
N
L
K
Q
V
S
F
G
A
K
G
N
G
I
T
Y
A
N
M
M
S
I
K
K
E
L
E
T
A
E
V
K
G
I
D
F
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
D
-
G
-
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
E
K
D
R
L
G
N
I
V
P
G
T
E
-
Q
V
S
Q
Q
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V
-
D
G
K
D
V
Y
T
T
I
S
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P
L
Q
S
F
M
E
T
Q
M
D
A
F
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E
K
V
K
G
K
Y
M
T
A
T
L
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S
A
K
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I
L
A
T
T
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P
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A
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K
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G
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F
V
--
W
R
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I
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Y
Q
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N
Y
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P
G
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T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
---
E
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
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L
L
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M
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W
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L
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K
F
G
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P
T
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G
L
T
D
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Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
M
S
A
F
G
Q
G
I
S
V
T
Q
T
Q
M
L
R
A
F
T
A
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D
G
V
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L
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Y
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Q
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K
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Q
K
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V
G
N
P
V
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K
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A
-
A
S
V
T
R
D
H
M
V
M
V
G
T
D
P
T
Y
G
T
M
Y
NH
S
T
--
G
------
K
A
T
-
V
N
V
P
G
Q
N
V
A
L
K
S
G
T
A
E
I
A
D
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K
N
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G
Y
L
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T
N
N
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V
V
S
M
H
P
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Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
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F
A
N
P
I
L
E
R
A
S
A
M
K
---
E
S
L
NLQT
T
A
K
A
L
E
Q
V
S
Q
Q
S
P
Y
P
M
P
S
V
K
D
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D
L
A
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L
R
R
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L
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Q
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V
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T
G
T
K
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K
N
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K
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L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
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P
D
M
Y
G
W
T
K
E
T
A
E
T
F
A
K
W
L
N
I
E
L
E
F
E
G
S
-
G
S
-
T
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
K
L
T
L
G
D
57
Fugue
90.47
58%
-56
- C1 -
1QME
3
PBPX_STRPN
A:
[23-702]
----------------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
---------------------------------------------------------------------------------
T
---------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
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N
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D
-
G
S
K
S
-
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
----------------------
R
T
M
-
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
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K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
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L
A
T
T
Q
R
P
T
F
D
A
D
T
K
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G
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F
--
V
W
R
D
I
L
Y
Q
S
N
Y
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P
G
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M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
---
E
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
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Y
L
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F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
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A
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T
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M
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L
V
G
T
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Y
G
T
M
Y
NH
S
T
--
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
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A
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K
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M
S
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A
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E
H
---
Y
S
G
I
Q
L
G
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F
A
N
P
I
L
E
R
A
S
A
M
K
---
D
S
L
N-----------
L
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
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L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
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K
N
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A
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A
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N
Q
Q
V
L
I
L
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A
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P
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M
Y
G
W
T
K
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A
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L
N
I
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L
E
F
Q
G
--
S
G
S
T
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
D
56
Fugue
90.21
57%
-56
- C1 -
1QME
3
PBPX_STRPN
A:
[23-702]
----------------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
------------------------------------------------------------------------------------------
V
P
I
A
E
D
A
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
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L
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N
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D
-
G
S
K
S
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L
L
G
T
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G
M
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S
S
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N
S
I
L
A
G
T
D
G
R
----------------------
T
M
-
D
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K
D
V
Y
T
T
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S
P
L
Q
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M
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M
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L
A
T
T
Q
R
P
T
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D
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K
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T
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V
W
R
D
I
L
Y
Q
S
N
Y
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G
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K
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M
M
L
A
A
A
I
D
N
N
T
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G
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F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
---
E
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
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S
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N
V
G
M
T
L
L
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G
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P
T
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G
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A
G
Q
L
P
A
D
---
N
---
I
---
V
N
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T
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T
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M
V
L
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T
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G
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Y
NH
S
T
--
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
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N
G
G
Y
L
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L
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S
A
V
S
M
S
P
A
E
N
P
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I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
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F
A
N
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L
E
R
A
S
A
M
K
---
D
S
-----------
L
N
L
Q
Q
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Y
P
M
P
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K
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T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
S
--
G
S
T
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
D
2
PsiBlast_PDB
89.94
55%
-57
- C1 -
1QME
3
PBPX_STRPN
A:
[23-702]
----------------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
D
-
G
-
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
----------------------
R
T
M
-
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
--
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
---
E
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
-
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
NH
S
T
--
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
---
D
S
L
NLQ-----------
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
S
-
G
S
-
T
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
D
21
PsiBlast_CBE
89.66
55%
-60
- C1 -
1RP5
1
PBPX_STRPN
B:
[16-702]
---------------------------------------------------------------------
K
V
H
Q
T
T
R
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
V
I
D
E
N
Y
K
S
A
T
G
K
I
L
Y
V
E
K
T
Q
F
N
K
V
A
E
V
F
H
K
Y
L
D
M
E
E
S
Y
V
R
E
Q
L
S
Q
P
N
L
K
Q
V
S
F
G
A
K
G
N
G
I
T
Y
A
N
M
M
S
I
K
K
E
L
E
T
A
E
V
K
G
I
D
F
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
D
-
G
-
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
E
K
D
R
L
G
N
I
V
P
G
T
E
-
Q
V
S
Q
Q
T
V
-
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
--
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
----------
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
M
S
A
F
G
Q
G
I
S
V
T
Q
T
Q
M
L
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
L
Y
D
P
N
D
Q
S
V
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
E
A
-
A
S
V
T
R
D
H
M
V
M
V
G
T
D
P
T
Y
G
T
M
Y
NH
S
T
--
G
------
K
A
T
-
V
N
V
P
G
Q
N
V
A
L
K
S
G
T
A
E
I
A
D
E
K
N
G
G
Y
L
T
G
S
T
N
N
I
F
S
V
V
S
M
H
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
---
E
S
L
NLQT
T
A
K
A
L
E
Q
V
S
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
F
A
K
W
L
N
I
E
L
E
F
E
G
S
-
G
S
-
T
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
K
L
T
L
G
D
27
HHSearch
88.11
55%
-55
- C1 -
1QME
3
PBPX_STRPN
A:
[23-702]
----------------------------------------------------------------------------
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
------------------------------------------------------------------------------------------
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
D
G
S
-
K
S
-
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
----------------------
R
T
M
-
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
--
E
D
F
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
E
GL
T
G
G
---
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
-
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
-------
Y
G
--
T
MYNHST
G
K
P
T
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
D
S
L
N
L
Q
--------------
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
S
G
S
T
--
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
D
3
PsiBlast_PDB
87.80
54%
-58
- C1 -
1PYY
3
PBPX_STRR6
A:
[25-702]
------------------------------------------------------------------------------
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
A
T
S
Y
N
V
Y
A
---------------------
N
K
V
A
E
V
F
H
K
Y
L
D
M
E
E
S
Y
V
R
E
Q
L
-------
V
S
F
G
A
K
G
N
G
I
T
Y
A
N
M
M
S
------------------
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
D
-
G
-
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
---------------------------
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
--
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
A
F
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
---
E
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
-
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
NH
S
T
--
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
---
D
S
L
NLQT
T
A
K
A
L
E
Q
V
S
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
S
-
G
S
-
T
V
Q
K
Q
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
D
58
Fugue
83.57
54%
-47
- C1 -
1K25
-
?
A:
[67-750]
------------------------------------------------------------------------
Q
I
T
R
T
V
P
A
K
R
G
T
I
Y
D
R
N
G
V
P
I
A
E
D
---------------------------------------------------------------------------------
A
T
S
Y
N
V
Y
A
V
T
T
S
P
N
R
S
Y
P
N
G
Q
F
A
S
S
F
I
G
L
A
Q
L
H
E
N
E
D
-
G
-
S
K
S
L
L
G
T
S
G
M
E
S
S
L
N
S
I
L
A
G
T
D
G
I
I
T
Y
G
N
I
V
P
G
-----
T
E
-
L
V
S
Q
Q
T
V
-
D
G
K
D
V
Y
T
T
L
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
L
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
N
A
D
T
K
E
G
I
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
A
M
K
V
M
T
L
A
S
S
I
D
N
N
T
F
P
S
G
E
Y
F
N
S
S
--
E
L
----------------------------------
S
S
N
V
G
M
S
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
K
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
S
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
L
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
T
N
N
Q
S
V
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
E
A
-
A
S
T
T
R
N
H
M
I
L
V
G
T
D
P
--------------------
L
I
-
I
T
V
P
G
Q
N
V
A
V
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
S
T
N
Y
I
F
S
A
V
T
M
N
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
T
P
I
L
E
R
A
S
A
M
K
---
E
S
L
NLQS
P
A
K
N
L
D
K
V
T
T
E
S
S
Y
A
M
P
S
I
K
D
I
S
P
G
E
L
A
E
A
L
R
R
N
I
V
Q
P
I
V
V
G
T
G
T
K
I
K
E
T
S
V
E
E
G
T
N
L
A
P
N
Q
Q
V
L
L
L
S
D
K
V
E
E
I
P
D
M
Y
G
W
K
K
E
T
A
E
T
F
A
K
W
L
D
I
E
L
E
F
E
G
--
S
G
S
V
V
Q
K
Q
D
V
R
T
N
T
A
I
K
N
I
K
K
I
K
L
T
L
G
D
59
Fugue
70.42
60%
-69
- C1 -
1QME
3
PBPX_STRPN
A:
[216-572]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
--
V
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
---
E
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
-
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
--
N
H
ST
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
---
D
S
L
----
N
L
Q
Q
S
P
Y
P
M
P
S
V
K
D
I
S
P
G
D
L
A
E
E
L
R
R
N
L
V
Q
P
I
V
V
G
T
G
T
K
I
K
N
S
S
A
E
E
G
K
N
L
A
P
N
Q
Q
V
L
I
L
S
D
K
A
E
E
V
P
D
M
Y
G
W
T
K
E
T
A
E
T
L
A
K
W
L
N
I
E
L
E
F
Q
G
S
G
S
T
V
Q
K
Q
-
D
V
R
A
N
T
A
I
K
D
I
K
K
I
T
L
T
L
G
D
--------
22
PsiBlast_CBE
66.91
59%
-72
- C1 -
2ZC4
2
?
E:
[14-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
-
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
--
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
-----
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
-
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
NH
S
T
--
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
---
D
S
L
----
N
L
--------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
66.26
59%
-67
- C1 -
2Z2M
2
?
B:
[14-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
-
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
--
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
---
E
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
-
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
NH
S
T
--
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
----
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
---
D
S
L
----
N
L
--------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
66.16
59%
-69
- C1 -
2ZC3
1
?
B:
[14-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
-
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
--
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
---
E
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
-
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
NH
S
T
--
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
---
D
S
L
----
N
---------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
66.12
59%
-69
- C1 -
2ZC3
2
?
E:
[14-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
-
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
--
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
---
E
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
-
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
NH
S
T
--
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
---
D
S
L
----
N
L
--------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
65.94
59%
-65
- C1 -
2Z2L
1
?
B:
[14-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
-
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
--
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
---
E
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
-
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
NH
S
T
--
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
---
D
S
L
----
N
L
--------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
65.69
59%
-71
- C1 -
2Z2M
1
?
E:
[14-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
-
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
--
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
--------
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
-
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
NH
S
T
--
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
---
D
S
L
----
N
L
--------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.64
59%
-67
- C1 -
2ZC4
1
?
B:
[14-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
M
-
D
G
K
D
V
Y
T
T
I
S
S
P
L
Q
S
F
M
E
T
Q
M
D
A
F
Q
E
K
V
K
G
K
Y
M
T
A
T
L
V
S
A
K
T
G
E
I
L
A
T
T
Q
R
P
T
F
D
A
D
T
K
E
G
I
T
E
D
F
V
--
W
R
D
I
L
Y
Q
S
N
Y
E
P
G
S
T
M
K
V
M
M
L
A
A
A
I
D
N
N
T
F
P
G
G
E
V
F
N
S
S
--
E
L
K
I
A
D
A
T
I
R
D
W
D
V
N
---
E
G
L
T
G
G
R
M
M
T
F
S
Q
G
F
A
H
-
S
S
N
V
G
M
T
L
L
E
Q
K
M
G
D
A
T
W
L
D
Y
L
N
R
F
K
F
G
V
P
T
R
F
G
L
T
D
E
Y
A
G
Q
L
P
A
D
---
N
---
I
---
V
N
I
A
Q
S
S
F
G
Q
G
I
S
V
T
Q
T
Q
M
I
R
A
F
T
A
I
A
N
D
G
V
M
L
E
P
K
F
I
S
A
I
Y
D
P
N
D
Q
T
A
R
K
S
Q
K
E
I
V
G
N
P
V
S
K
D
A
-
A
S
L
T
R
T
N
M
V
L
V
G
T
D
P
V
Y
G
T
M
Y
NH
S
T
--
G
------
K
P
T
-
V
T
V
P
G
Q
N
V
A
L
K
S
G
T
A
Q
I
A
D
E
K
N
G
G
Y
L
V
G
L
T
D
Y
I
F
S
A
V
S
M
S
P
A
E
N
P
D
F
I
L
Y
V
T
V
Q
Q
P
--
E
H
---
Y
S
G
I
Q
L
G
E
F
A
N
P
I
L
E
R
A
S
A
M
K
---
D
S
L
----
N
---------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
60.67
25%
-47
* C1 *
3EQU
11
PBP2_NEIGO
A:
[24-532]
---------------------------------------------------------------------
N
R
I
V
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
-----------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
D
I
---------
D
-
G
K
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
S
L
D
S
P
R
N
K
A
P
Q
-
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
R
P
G
R
A
D
---
S
E
Q
R
R
N
R
A
V
T
D
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
Q
--
P
Y
K
I
G
P
S
P
V
R
D
T
H
------
V
Y
---
P
S
L
D
V
R
G
I
M
Q
K
-
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
RRW
R
---
P
---
I
E
Q
A
T
M
S
F
G
Y
G
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
P
L
S
F
E
K
Q
A
V
A
P
Q
G
-----------
K
R
I
F
K
E
S
T
-
A
R
E
V
R
N
L
M
V
S
V
T
E
P
G
---------
G
--
T
------
G
T
A
-
G
A
V
D
G
F
D
V
G
A
K
T
G
T
A
---------------
K
H
V
A
T
F
I
G
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
--
T
A
HGY
Y
G
G
V
V
A
G
P
P
F
K
K
I
M
G
G
S
L
N
I
L
---
G
I
S
----
P
T
K
P
L
T
----------------------------------------------------------------------------------------------------------------------------
60
Fugue
59.86
25%
-48
- C1 -
3OC2
3
?
A:
[35-545]
---------------------------------------------------------------------
A
R
S
V
R
H
I
A
I
P
A
H
R
G
L
I
T
D
R
N
G
E
P
L
A
V
S
T
P
V
T
T
L
W
A
---------
N
P
K
E
L
M
T
A
K
E
R
W
P
Q
L
A
A
A
L
----
G
Q
D
T
K
L
F
A
D
R
I
E
Q
N
A
------
E
R
E
F
I
Y
L
V
R
G
L
T
P
E
Q
G
E
G
V
I
A
L
K
V
P
G
V
Y
S
I
E
E
F
R
R
F
Y
P
A
G
E
V
V
A
H
A
V
G
F
T
D
V
D
D
R
G
----------
R
E
G
I
E
L
A
F
D
E
W
L
A
G
V
P
G
K
R
Q
V
L
K
D
R
R
G
R
V
I
K
D
V
Q
-
V
T
K
N
A
K
--
P
G
K
T
L
A
L
S
I
D
L
R
L
Q
Y
L
A
H
R
E
L
R
N
A
L
L
E
N
G
A
K
A
G
S
L
V
I
M
D
V
K
T
G
E
I
L
A
M
T
N
Q
P
T
Y
N
P
N
N
R
R
N
L
Q
P
A
A
M
---
R
N
R
A
M
I
D
V
F
E
P
G
S
T
V
K
P
F
S
M
S
A
A
L
A
S
G
R
W
K
P
S
D
I
V
D
V
Y
PG
T
L
Q
I
G
R
Y
T
I
R
D
V
S
R
N
---
S
R
-----
Q
L
D
L
T
G
I
L
I
K
-
S
S
N
V
G
I
S
K
I
A
F
D
I
G
A
E
S
I
Y
S
V
M
Q
Q
V
G
L
G
Q
D
T
G
L
G
F
P
G
E
R
V
G
N
L
P
N
H
---
R
KWP
K
---
A
E
T
A
T
L
A
Y
G
Y
G
L
S
V
T
A
I
Q
L
A
H
A
Y
A
A
L
A
N
D
G
K
S
V
P
L
S
M
T
-----------
R
V
D
R
V
P
D
G
V
Q
V
I
S
P
E
V
-
A
S
T
V
Q
G
M
L
Q
Q
V
V
E
A
Q
--
G
G
V
F
--
R
A
--------------
Q
V
P
G
Y
H
A
A
G
K
S
G
T
A
R
-------------
K
A
Y
R
S
L
F
A
G
F
A
P
A
T
D
P
R
I
A
M
V
V
V
I
D
E
P
FG
G
L
---
V
S
A
P
V
F
S
K
V
M
A
G
A
L
R
L
M
N
V
P
P
---
D
N
L
--------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
58.95
28%
-39
- C1 -
3EQU
11
PBP2_NEIGO
A:
[28-499]
-------------------------------------------------------------------------
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
-----------------------------------------------------------------------------------------
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
----
D
I
D
-
G
-
K
----
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
S
L
D
-
S
P
R
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
R
P
G
R
A
D
S
E
Q
--
R
R
N
R
A
V
T
D
M
-
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
Q
--
P
Y
K
I
G
P
S
P
V
R
D
T
H
V
Y
---
P
S
L
D
V
-------
R
G
I
M
Q
K
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
---
R
---
R
WR
P
I
E
Q
A
T
M
S
F
G
Y
G
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
P
L
S
F
E
K
Q
A
V
A
P
Q
------------
G
K
R
I
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
-
T
E
P
--
G
G
T
G
--
T
A
--
G
------
A
-----
V
D
G
F
D
V
G
A
K
T
G
T
A
---------------
K
H
V
A
T
F
I
G
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
--
T
A
---
H
G
Y
Y
G
G
V
V
A
G
P
P
F
K
K
I
M
G
G
S
L
---
N
I
L
----
G
I
S
P
T
K
P
L
T
-------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
58.72
29%
-39
- C1 -
3EQV
9
PBP2_NEIGO
A:
[28-499]
-------------------------------------------------------------------------
R
T
Q
A
L
P
A
T
R
G
T
V
S
D
R
N
G
A
V
L
A
L
S
A
P
T
E
----------------------------------------------------------------------------------------
E
L
K
R
H
Y
P
M
G
N
L
F
A
H
V
I
G
F
T
----
D
I
D
-
G
-
K
----
G
Q
E
G
L
E
L
S
L
E
D
S
L
Y
G
E
D
G
A
E
V
V
L
R
D
R
Q
G
N
I
V
D
S
L
D
-
S
P
R
N
K
A
P
Q
N
G
K
D
I
I
L
S
L
D
Q
R
I
Q
T
L
A
Y
E
E
L
N
K
A
V
E
Y
H
Q
A
K
A
G
T
V
V
V
L
D
A
R
T
G
E
I
L
A
L
A
N
T
P
A
Y
D
P
N
R
P
G
R
A
D
S
E
Q
--
R
R
N
R
A
V
T
D
-
M
I
E
P
G
S
A
I
K
P
F
V
I
A
K
A
L
D
A
G
K
T
D
L
N
E
R
L
N
T
Q
--
P
Y
K
I
G
P
S
P
V
R
D
T
H
V
Y
---
P
S
L
D
V
R
G
I
M
Q
------
K
-
S
S
N
V
G
T
S
K
L
S
A
R
F
G
A
E
E
M
Y
D
F
Y
H
E
L
G
I
G
V
R
M
H
S
G
F
P
G
E
T
A
G
L
L
R
N
W
---
R
---
R
WR
P
I
E
Q
A
T
M
S
F
G
Y
G
L
Q
L
S
L
L
Q
L
A
R
A
Y
T
A
L
T
H
D
G
V
L
L
P
L
S
F
E
K
Q
A
V
A
P
Q
------------
G
K
R
I
F
K
E
S
T
A
R
E
V
R
N
L
M
V
S
V
-
T
E
P
--
G
G
T
G
--
T
A
--
G
------
A
-----
V
D
G
F
D
V
G
A
K
T
G
T
A
R
--
K
--------
N
K
H
--
V
G
T
F
I
G
F
A
P
A
K
N
P
R
V
I
V
A
V
T
I
D
E
P
--
T
A
---
H
G
Y
Y
G
G
V
V
A
G
S
P
F
K
K
I
M
G
G
S
L
---
N
I
L
----
G
I
S
P
T
K
P
L
T
-------------------------------------------------------------------------------------------------------------------------