@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0279: (2015-11-29 )
MSFKDFNFKPYIQRALDELKFVDPTDVQAKLIPVVRSGRDLVGESKTGSGKTHTFLLPIFEKLDESSDDVQVVITAPSRELGTQIYQATKQIAEHSEQEIRVVNYVGGTDKLRQIEKLKVSQPHIVIGTPGRIYDLVKSGDLAIHKAHTFVVDEADMTLDMGFLDTVDKIAGSLPKDVQILVFSATIPQKLQPFLKKYLTNPVMEKIKTATVIADTIDNWLLSTKGRDKNAQILELSKLMQPYLAMIFVNTKERADELHSYLSSNGLKVAKIHGGIAPRERKRIMNQVKNLEFEYIVATDLAARGIDIEGVSHVINDAIPQDLSFFVHRVGRTGRNGLSGTAITLYQPSDDSDIRELEKLGINFIPKVIKNGEFQDTYDRDRRNNREKSYQKLDTEMIGLVKKKKKKIKPGYKKKIQWKVDEKRRKERRASNRAKGRAERKAKKQSF
Atome Classification :
(27 SA)
.........10........20........30......--.--.40........50........60..--..----.------------------.-----.---.70.----------------.......80........90......--.--.100.......110.......120.......130.......140......--..150.......160.-....---...170.---.----.-------...-.180.......190.......200----.......210--.----....---....220...-.-..-.230--....-..-..-.-240.......250.......260...---....270.......280.......290.......300.......310.......320-----........330.......340.......350......-..-360-...---.....370.......380.......390.......400.......410.......420.......430.......440.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSFKDFN
F
K
P
Y
I
Q
R
A
L
D
ELKFVDPTDVQ
A
K
L
I
P
V
VRS--G--
R
D
LVGESKTGSGK
T
H
T
F
L
L
P
I
F
E
KL--DE----S------------------S-----D---
D
V
Q
V
----------------
V
I
TAP
S
R
E
L
G
T
Q
I
Y
Q
A
T
K
Q
I
A
E
HSE--Q--
E
I
R
V
V
N
YVG
G
T
D
K
L
R
Q
I
E
K
LKVSQP
H
I
V
IGTP
G
R
I
Y
D
LVKSG-
D
L
A
I
H
K
A
--
H
T
F
V
V
DEAD
M
T
L
D
M
-
G
-
F
L
D
T
---
V
D
K
I
A
GS---L----P-------K
D
V
-
Q
I
L
V
F
SATI
P
Q
K
L
Q
P
F
L
K
K
YLT
N
P
----
V
M
E
K
I
K
T
A
----
T
----
V
I
A
D
---
T
I
D
N
W
L
L
STK-G-RD-KN----
A
Q
I
L
-
E
L
-
S
K
-
L
-
M
Q
P
Y
L
A
M
I
F
VN
T
K
E
R
A
D
E
L
H
S
Y
L
S
SN---G
L
K
V
A
K
IHGGIA
P
R
E
R
K
R
I
M
N
Q
V
KN
L
E
F
E
Y
I
V
ATDLAARGI
D
I
E
G
V
S
H
V
I
N
DAI
P
Q
------
D
L
S
F
F
V
H
R
VGRTGRNGLSG
T
A
I
T
L
YQPSD
D
-
S
D
I
R
E
L
-
E
K
-
L
G
--
I
N
F
---
I
P
K
V
IKNGEFQD
T
Y
D
RDRRN
N
R
E
K
S
Y
Q
K
L
D
T
E
M
I
G
L
V
K
K
K
K
K
KIKPGYK
K
K
I
Q
W
KV
D
E
K
R
R
K
E
R
RASNRAKG
R
A
E
R
KAKKQSF
26
PsiBlast_CBE
90.88
34%
-101
- C5 -
4KBG
4
?
B:
[1-355]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
P
----
S
------------------
Q
-----
E
RGR
K
P
R
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
--------
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
-
V
L
D
L
S
R
V
--
E
V
A
V
L
D
E
A
D
E
M
L
S
M
-
G
-
F
E
E
E
---
V
E
A
L
L
S
A
---
T
----
P
-------
P
S
R
-
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
----
V
L
-----
I
----
N
----
V
I
K
D
EPV
T
Y
E
E
E
A
V
P
A
P
-
V
-
R
G
-
R
L
----
E
V
L
S
-
D
L
-
L
Y
-
V
-
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
R
-
R
D
V
E
A
L
-
E
R
-
A
V
--
G
R
R
---
F
K
R
V
N
------------------------------------------------------------------------------
27
PsiBlast_CBE
90.29
34%
-108
- C5 -
4KBF
1
?
B:
[1-355]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
P
----
S
------------------
Q
-----
E
RGR
K
P
R
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
--------
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
-
V
L
D
L
S
R
V
--
E
V
A
V
L
D
E
A
D
E
M
L
S
M
-
G
-
F
E
E
E
---
V
E
A
L
L
S
A
---
T
----
P
-------
P
S
R
-
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
----
V
L
-----
I
----
N
----
V
I
K
D
EPV
T
Y
E
E
E
A
V
P
A
P
-
V
-
R
G
-
R
L
----
E
V
L
S
-
D
L
-
L
Y
-
V
-
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
R
-
R
D
V
E
A
L
-
E
R
-
A
V
--
G
R
R
---
F
K
R
V
N
------------------------------------------------------------------------------
5
PsiBlast_PDB
88.59
30%
-101
- C5 -
2I4I
1
DDX3X_HUMAN
A:
[16-415]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
----
P
------------------
G
-----
E
---
A
L
R
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
R
------
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
-
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
G
-
K
I
G
L
D
F
C
--
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
-
G
-
F
E
P
Q
---
I
R
R
I
V
E
Q
DTM
P
----
P
-------
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
----
I
F
L
A
V
G
------------
T
S
E
---
N
I
T
Q
K
V
V
W
V
E
-
E
-
S
D
-
K
R
----
S
F
L
L
-
D
L
L
N
A
-
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
I
-
N
I
T
K
D
L
-
L
D
-
L
L
--
V
E
A
KQE
V
P
S
W
L
E
N
M
A
Y
E
H
H
Y
---------------------------------------------------------------------
16
PsiBlast_PDB
88.26
34%
-96
- C5 -
4KBF
3
?
A:
[1-355]
M
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
--
A
P
----
S
------------------
Q
-----
E
RGR
K
P
R
A
----------------
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
--------
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
R
Q
G
-
V
L
D
L
S
R
V
--
E
V
A
V
L
D
E
A
D
E
M
L
S
M
-
G
-
F
E
E
E
---
V
E
A
L
L
S
A
---
T
----
P
-------
P
S
R
-
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
----
V
L
-----
I
----
N
----
V
I
K
D
EPV
T
Y
E
E
E
A
V
P
A
P
-
V
-
R
G
-
R
L
----
E
V
L
S
-
D
L
-
L
Y
-
V
-
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
R
-
R
D
V
E
A
L
-
E
R
-
A
V
--
G
R
R
---
F
K
R
V
N
------------------------------------------------------------------------------
30
PsiBlast_CBE
87.94
31%
-113
- C5 -
2VSX
1
IF4A_YEAST
A:
[24-378]
--
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
--
D
T
----
S
------------------
V
-----
K
---
A
P
Q
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
----
M
--
D
I
K
V
H
A
C
I
G
----------
L
R
D
A
Q
--
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
-
R
F
R
T
D
K
I
--
K
M
F
I
L
D
E
A
D
E
M
L
S
S
-
G
-
F
K
E
Q
---
I
Y
Q
I
F
T
L
---
L
----
P
-------
P
T
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
----
V
R
I
L
V
K
K
D
----
E
----
L
T
L
E
---
G
I
K
Q
F
Y
V
N
V
E
-
E
-
E
E
-
Y
K
----
Y
E
C
L
T
D
L
-
Y
D
-
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
N
Y
I
H
R
I
G
------
R
K
G
V
A
I
N
F
V
T
N
E
D
V
-
G
A
M
R
E
L
-
E
K
-
F
Y
--
S
T
Q
---
I
E
E
L
P
S
D
I
A
T
L
------------------------------------------------------------------------
31
PsiBlast_CBE
87.83
31%
-112
- C5 -
2VSO
1
IF4A_YEAST
B:
[24-378]
--
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
--
D
T
----
S
------------------
V
-----
K
---
A
P
Q
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
----
M
--
D
I
K
V
H
A
C
I
G
----------
L
R
D
A
Q
--
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
-
R
F
R
T
D
K
I
--
K
M
F
I
L
D
E
A
D
E
M
L
S
S
-
G
-
F
K
E
Q
---
I
Y
Q
I
F
T
L
---
L
----
P
-------
P
T
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
----
V
R
I
L
V
K
K
D
----
E
----
L
T
L
E
---
G
I
K
Q
F
Y
V
N
V
E
-
E
-
E
E
-
Y
K
----
Y
E
C
L
T
D
L
-
Y
D
-
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
N
Y
I
H
R
I
G
------
R
K
G
V
A
I
N
F
V
T
N
E
D
V
-
G
A
M
R
E
L
-
E
K
-
F
Y
--
S
T
Q
---
I
E
E
L
P
S
D
I
A
T
L
------------------------------------------------------------------------
29
PsiBlast_CBE
87.79
31%
-113
- C5 -
2VSX
1
IF4A_YEAST
B:
[24-378]
--
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
--
D
T
----
S
------------------
V
-----
K
---
A
P
Q
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
----
M
--
D
I
K
V
H
A
C
I
G
----------
L
R
D
A
Q
--
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
-
R
F
R
T
D
K
I
--
K
M
F
I
L
D
E
A
D
E
M
L
S
S
-
G
-
F
K
E
Q
---
I
Y
Q
I
F
T
L
---
L
----
P
-------
P
T
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
----
V
R
I
L
V
K
K
D
----
E
----
L
T
L
E
---
G
I
K
Q
F
Y
V
N
V
E
-
E
-
E
E
-
Y
K
----
Y
E
C
L
T
D
L
-
Y
D
-
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
N
Y
I
H
R
I
G
------
R
K
G
V
A
I
N
F
V
T
N
E
D
V
-
G
A
M
R
E
L
-
E
K
-
F
Y
--
S
T
Q
---
I
E
E
L
P
S
D
I
A
T
L
------------------------------------------------------------------------
20
PsiBlast_PDB
87.67
31%
-103
- C5 -
1S2M
-
DHH1_YEAST
A:
[47-413]
-
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
--
K
P
----
K
------------------
L
-----
N
---
K
I
Q
A
----------------
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
------
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
N
-
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
K
-
V
A
D
L
S
D
C
--
S
L
F
I
M
D
E
A
D
K
M
L
S
R
-
D
-
F
K
T
I
---
I
E
Q
I
L
S
F
---
L
----
P
-------
P
T
H
-
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
YEIN
L
M
E
E
L
T
-------------
L
K
---
G
I
T
Q
Y
Y
A
F
V
E
-
E
-
R
Q
-
K
L
----
H
C
L
N
-
T
L
-
F
S
-
K
-
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
-
F
N
L
Y
K
I
-
E
Q
E
L
G
T
E
I
A
A
---
I
P
A
T
I
D
K
S
L
Y
V
A
E
N
---------------------------------------------------------------------
100
HHSearch
87.48
34%
-88
- C5 -
2DB3
3
VASA1_DROME
A:
[57-408]
-
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
--
L
E
----
D
------------------
P
H
E
L
E
L
G
---
R
P
Q
V
----------------
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
S
------
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
-
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
F
V
D
R
T
-
F
I
T
F
E
D
T
--
R
F
V
V
L
D
E
A
D
R
M
L
D
M
-
G
-
F
S
E
D
---
M
R
R
I
M
T
H
---
V
----
T
MR-----
P
E
H
-
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
----
V
F
V
A
I
G
I
V
----
G
----
G
A
C
S
---
D
V
K
Q
T
I
Y
E
V
N
-
K
-
Y
A
-
K
R
----
S
K
L
I
-
E
I
-
L
S
-
E
--
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
D
-
R
A
I
A
A
D
-
L
V
-
K
I
--
L
E
G
---
S
G
Q
T
V
P
D
F
L
R
-------------------------------------------------------------------------
32
PsiBlast_CBE
87.43
31%
-113
- C5 -
2VSO
1
IF4A_YEAST
A:
[24-378]
--
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
--
D
T
----
S
------------------
V
-----
K
---
A
P
Q
A
----------------
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
----
M
--
D
I
K
V
H
A
C
I
G
----------
L
R
D
A
Q
--
I
V
V
G
T
P
G
R
V
F
D
N
I
Q
R
R
-
R
F
R
T
D
K
I
--
K
M
F
I
L
D
E
A
D
E
M
L
S
S
-
G
-
F
K
E
Q
---
I
Y
Q
I
F
T
L
---
L
----
P
-------
P
T
T
-
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
----
V
R
I
L
V
K
K
D
----
E
----
L
T
L
E
---
G
I
K
Q
F
Y
V
N
V
E
-
E
-
E
E
-
Y
K
----
Y
E
C
L
T
D
L
-
Y
D
-
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
E
N
Y
I
H
R
I
G
------
R
K
G
V
A
I
N
F
V
T
N
E
D
V
-
G
A
M
R
E
L
-
E
K
-
F
Y
--
S
T
Q
---
I
E
E
L
P
S
D
I
A
T
L
------------------------------------------------------------------------
110
HHSearch
87.18
32%
-103
- C5 -
2I4I
1
DDX3X_HUMAN
A:
[16-391]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
--
Y
S
----
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
-----
Q
---
Y
P
I
S
----------------
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
R
------
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
G
-
K
I
G
L
D
F
C
--
K
Y
L
V
L
D
E
A
D
R
M
L
D
M
-
G
-
F
E
P
Q
---
I
R
R
I
V
E
Q
---
D
TMPP
K
-------
G
V
R
-
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
----
I
F
L
A
V
G
------------
T
S
E
---
N
I
T
Q
K
V
V
W
V
E
-
E
-
S
D
-
K
R
----
S
F
L
L
-
D
L
-
L
N
-
A
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
I
-
N
I
T
K
D
L
-
L
D
-
L
L
--
V
E
A
---
K
Q
E
V
P
S
W
L
E
N
M
A
Y
E
H
H
Y
------------------------------------------------------------------
2
PsiBlast_PDB
86.77
32%
-100
- C5 -
4CT4
3
DDX6_HUMAN
B:
[7-368]
--
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
--
D
L
----
K
------------------
K
-----
D
---
N
I
Q
A
----------------
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
--
G
--
A
-
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
D
-
D
T
V
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
K
G
-
V
A
K
V
D
H
V
--
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
-
D
-
F
V
Q
I
---
M
E
D
I
I
L
T
---
L
----
P
-------
K
N
R
-
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
YEIN
L
M
E
E
L
T
L
K
----
G
----
V
--------
T
Q
Y
Y
A
Y
V
T
-
E
-
R
Q
-
K
V
----
H
C
L
N
-
T
L
-
F
S
-
R
-
L
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
R
-
F
N
L
K
S
I
E
E
Q
-
L
G
--
T
E
I
---
K
P
I
P
S
N
I
D
K
S
L
Y
-----------------------------------------------------------------------
13
PsiBlast_PDB
86.70
30%
-88
- C5 -
4PXA
6
DDX3X_HUMAN
A:
[66-461]
-
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
----
P
------------------
G
-----
E
---
A
L
R
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
R
------
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
M
M
E
R
G
-
K
I
G
L
D
F
C
--
K
Y
L
V
L
D
E
A
D
R
M
L
V
M
-
G
-
F
E
P
Q
---
I
R
R
I
V
E
Q
DTM
P
----
P
-------
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
----
I
F
L
A
V
G
R
V
----
G
----
S
T
S
E
---
N
I
T
Q
K
V
V
W
V
E
-
E
-
S
D
-
K
R
----
S
F
L
L
-
D
L
L
N
A
-
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
N
I
-
N
I
T
K
D
L
-
L
D
-
L
L
--
V
E
A
KQE
V
P
S
W
L
E
N
M
A
Y
-------------------------------------------------------------------------
22
PsiBlast_CBE
86.63
32%
-92
- C5 -
4CT4
2
DDX6_HUMAN
D:
[7-368]
--
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
--
D
L
----
K
------------------
K
-----
D
---
N
I
Q
A
----------------
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
--
G
--
A
-
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
D
-
D
T
V
H
V
V
I
A
T
P
G
R
I
L
D
L
I
K
K
G
-
V
A
K
V
D
H
V
--
Q
M
I
V
L
D
E
A
D
K
L
L
S
Q
-
D
-
F
V
Q
I
---
M
E
D
I
I
L
T
---
L
----
P
-------
K
N
R
-
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
L
T
L
K
----
G
----
V
--------
T
Q
Y
Y
A
Y
V
T
-
E
-
R
Q
-
K
V
----
H
C
L
N
-
T
L
-
F
S
-
R
-
L
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
----
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
R
-
F
N
L
K
S
I
E
E
Q
-
L
G
--
T
E
I
---
K
P
I
P
S
------------------------------------------------------------------------------
104
HHSearch
86.62
29%
-100
- C5 -
3FHT
4
DD19B_HUMAN
A:
[26-390]
-
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
--
E
P
----
A
------------------
N
-----
K
---
Y
P
Q
C
----------------
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-----
E
L
K
L
A
Y
A
V
R
G
N
K
L
----
E
R
G
Q
K
I
S
E
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
S
K
L
K
F
I
D
P
K
K
I
--
K
V
F
V
L
D
E
A
D
V
M
I
A
T
Q
G
-
H
Q
D
Q
---
S
I
R
I
Q
R
M
---
L
----
P
-------
R
N
C
-
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
----
N
V
I
K
L
K
R
E
----
E
----
E
T
L
D
---
T
I
K
Q
Y
Y
V
L
C
S
-
S
R
D
E
-
K
F
----
Q
A
L
C
-
N
L
-
Y
G
-
A
-
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
M
N
I
L
N
R
I
-
Q
E
-
H
F
--
N
K
K
---
I
E
R
L
-------------------------------------------------------------------------------
103
HHSearch
86.61
31%
-95
- C5 -
3I5X
3
MS116_YEAST
A:
[78-459]
------
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
--
I
N
----
T
KFDS--------------
Q
-----
Y
---
M
V
K
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
GL
K
--
K
Y
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
K
L
R
P
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
Y
S
N
K
F
F
R
F
V
--
D
Y
K
V
L
D
E
A
D
R
L
L
E
I
-
G
-
F
R
D
D
---
L
E
T
I
S
G
I
---
L
----
N
E
K
NSKSA
D
N
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
----
E
C
L
F
L
D
T
V
DKNE
P
----
E
A
H
E
---
R
I
D
Q
S
V
V
I
S
E
-
K
F
A
N
-
S
I
F
A
A
V
E
H
I
K
-
K
Q
-
I
K
E
R
-
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
L
-
P
F
V
R
E
L
-
E
D
-
A
K
--
N
I
V
---
I
A
K
Q
E
K
Y
E
P
S
E
E
I
K
S
E
V
L
E
A
V
T
E
E
P
E
D
I
S
D
I
V
I
S
L
I
S
S
Y
R
S
C
I
K
E
Y
R
F
S
E
R
R
I
L
P
E
I
A
S
T
Y
G
V
L
L
N
D
P
Q
L
K
I
P
V
S
R
R
F
L
D
K
L
G
28
PsiBlast_CBE
86.45
31%
-103
- C5 -
4BRW
2
DHH1_YEAST
A:
[2-368]
-
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
--
K
P
----
K
------------------
L
-----
N
---
K
I
Q
A
----------------
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
C
------
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
N
-
E
T
V
H
I
L
V
G
T
P
G
R
V
L
D
L
A
S
R
K
-
V
A
D
L
S
D
C
--
S
L
F
I
M
D
E
A
D
K
M
L
S
R
-
D
-
F
K
T
I
---
I
E
Q
I
L
S
F
---
L
----
P
-------
P
T
H
-
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
M
E
E
L
T
-------------
L
K
---
G
I
T
Q
Y
Y
A
F
V
E
-
E
-
R
Q
-
K
L
----
H
C
L
N
-
T
L
-
F
S
-
K
-
L
Q
I
N
Q
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
D
R
-
F
N
L
Y
K
I
-
E
Q
E
L
G
T
E
I
A
A
---
I
P
A
T
I
D
K
S
L
Y
V
A
E
----------------------------------------------------------------------
11
PsiBlast_PDB
86.38
28%
-93
- C5 -
3EX7
4
IF4A3_HUMAN
C:
[39-394]
-
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--
D
I
----
Q
------------------
V
-----
R
---
E
T
Q
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
N
--
V
--
Q
C
H
A
C
--
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
-
S
L
R
T
R
A
I
--
K
M
L
V
L
D
E
A
D
E
M
L
N
K
-
G
-
F
K
E
Q
---
I
Y
D
V
Y
R
Y
---
L
----
P
-------
P
A
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
----
I
R
I
L
V
K
R
D
----
E
----
L
T
L
E
---
G
I
K
Q
F
F
V
A
V
E
-
R
-
E
E
W
K
F
----
D
T
L
C
-
D
L
-
Y
D
-
T
-
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
-
R
I
L
R
D
I
-
E
Q
-
Y
Y
--
S
T
Q
---
I
D
E
M
P
M
N
V
A
D
L
I
L
E
---------------------------------------------------------------------
109
HHSearch
86.35
31%
-93
- C5 -
3SQW
3
MS116_YEAST
A:
[25-408]
----
E
G
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
--
I
N
----
T
KFDS--------------
Q
-----
Y
---
M
V
K
A
----------------
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
--
G
LK
K
Y
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
K
L
R
P
N
I
V
I
A
T
P
G
R
L
I
D
V
L
E
K
Y
S
N
K
F
F
R
F
V
--
D
Y
K
V
L
D
E
A
D
R
L
L
E
I
-
G
-
F
R
D
D
---
L
E
T
I
S
G
I
---
L
----
N
E
K
NSKSA
D
N
I
-
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
----
E
C
L
F
L
D
T
V
----
D
KNEP
E
A
H
E
---
R
I
D
Q
S
V
V
I
S
E
K
F
-
A
N
-
S
I
F
A
A
V
E
H
I
K
-
K
Q
-
I
K
E
R
-
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
L
-
P
F
V
R
E
L
-
E
D
-
A
K
--
N
I
V
---
I
A
K
Q
E
K
Y
E
P
S
E
E
I
K
S
E
V
L
E
A
V
T
E
E
P
E
D
I
S
D
I
V
I
S
L
I
S
S
Y
R
S
C
I
K
E
Y
R
F
S
E
R
R
I
L
P
E
I
A
S
T
Y
G
V
L
L
N
D
P
Q
L
K
I
P
V
S
R
R
F
L
D
K
L
G
8
PsiBlast_PDB
85.84
28%
-92
- C5 -
2J0S
3
IF4A3_HUMAN
A:
[38-393]
-
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--
D
I
----
Q
------------------
V
-----
R
---
E
T
Q
A
----------------
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
N
--
V
--
Q
C
H
A
C
--
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
M
I
R
R
R
-
S
L
R
T
R
A
I
--
K
M
L
V
L
D
E
A
D
E
M
L
N
K
-
G
-
F
K
E
Q
---
I
Y
D
V
Y
R
Y
---
L
----
P
-------
P
A
T
-
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
----
I
R
I
L
V
K
R
D
----
E
----
L
T
L
E
---
G
I
K
Q
F
F
V
A
V
E
-
R
-
E
E
W
K
F
----
D
T
L
C
-
D
L
-
Y
D
-
T
-
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
I
-
R
I
L
R
D
I
-
E
Q
-
Y
Y
--
S
T
Q
---
I
D
E
M
P
M
N
V
A
D
L
I
-----------------------------------------------------------------------
50
PsiBlast_CBE
64.31
32%
-106
- C5 -
1T6N
1
DX39B_HUMAN
B:
[16-216]
--
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
--
E
P
----
V
------------------
T
-----
G
---
Q
V
S
V
----------------
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
P
--
N
---
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
K
K
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
N
K
-
S
L
N
L
K
H
I
--
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
----
L
D
M
RRD
V
Q
E
I
F
R
M
---
T
----
P
-------
H
E
K
-
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
----
M
E
I
F
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
63.93
32%
-104
- C5 -
1T6N
1
DX39B_HUMAN
A:
[16-216]
--
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
--
E
P
----
V
------------------
T
-----
G
---
Q
V
S
V
----------------
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
P
--
N
---
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
K
K
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
L
A
R
N
K
-
S
L
N
L
K
H
I
--
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
----
L
D
M
R
R
D
V
Q
E
I
F
R
M
---
T
----
P
-------
H
E
K
-
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
----
M
E
I
F
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
60.00
35%
-96
- C5 -
2OXC
1
DDX20_HUMAN
B:
[44-228]
--------------------
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
L
--
V
L
----
E
------------------
N
-----
L
---
S
T
Q
I
----------------
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
M
E
--
G
L-
E
C
H
V
--
F
I
G
G
T
-
P
L
S
Q
-
D
K
T
R
L
K
K
C
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
D
-
Y
L
N
P
G
S
I
--
R
L
F
I
L
D
E
A
D
K
L
L
E
E
-
G
S
F
Q
E
Q
---
I
N
W
I
Y
S
S
---
L
----
P
-------
A
S
K
-
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
----
T
F
V
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
59.82
35%
-92
- C5 -
3B7G
1
DDX20_HUMAN
B:
[44-228]
--------------------
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
L
--
V
L
----
E
------------------
N
-----
L
---
S
T
Q
I
----------------
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
M
E
--
G
L-
E
C
H
V
--
F
I
G
G
T
-
P
L
S
Q
-
D
K
T
R
L
K
K
C
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
D
-
Y
L
N
P
G
S
I
--
R
L
F
I
L
D
E
A
D
K
L
L
E
E
-
G
S
F
Q
E
Q
---
I
N
W
I
Y
S
S
---
L
----
P
-------
A
S
K
-
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
----
T
F
V
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
59.69
35%
-96
- C5 -
2OXC
1
DDX20_HUMAN
A:
[44-228]
--------------------
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
L
--
V
L
----
E
------------------
N
-----
L
---
S
T
Q
I
----------------
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
M
E
--
G
L
-
E
C
H
V
--
F
I
G
G
T
-
P
L
S
Q
-
D
K
T
R
L
K
K
C
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
D
-
Y
L
N
P
G
S
I
--
R
L
F
I
L
D
E
A
D
K
L
L
E
E
-
G
S
F
Q
E
Q
---
I
N
W
I
Y
S
S
---
L
----
P
-------
A
S
K
-
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
----
T
F
V
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
59.45
32%
-109
- C5 -
2PL3
5
DDX10_HUMAN
A:
[27-227]
--
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
--
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
--
Y
R
L
QWT
S
------------------
T
-----
D
---
G
L
G
V
----------------
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
K
N
H
D
--
F
--
S
A
G
L
I
--
I
G
G
--
L
K
H
E
A
E
--
R
I
N
N
I
N
I
L
V
C
T
P
G
R
L
L
Q
H
M
D
E
--
T
V
S
F
H
A
T
DL
Q
M
L
V
L
D
E
A
D
R
I
L
D
M
-
G
-
F
A
D
T
---
M
N
A
V
I
E
N
---
L
----
P
-------
K
K
R
-
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
----
E
Y
V
W
V
H
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
58.97
35%
-94
- C5 -
3B7G
1
DDX20_HUMAN
A:
[44-228]
--------------------
F
E
R
P
S
P
V
Q
L
K
A
I
P
L
G
R
C
--
G
--
L
D
L
I
V
Q
A
K
S
G
T
G
K
T
C
V
F
S
T
I
A
L
D
S
L
--
V
L
----
E
------------------
N
-----
L
---
S
T
Q
I
----------------
L
I
L
A
P
T
R
E
I
A
V
Q
I
H
S
V
I
T
A
I
G
I
K
M
E
--
G
L
-
E
C
H
V
--
F
I
G
G
T
-
P
L
S
Q
-
D
K
T
R
L
K
K
C
H
I
A
V
G
S
P
G
R
I
K
Q
L
I
E
L
D
-
Y
L
N
P
G
S
I
--
R
L
F
I
L
D
E
A
D
K
L
L
E
E
-
G
S
F
Q
E
Q
---
I
N
W
I
Y
S
S
---
L
----
P
-------
A
S
K
-
Q
M
L
A
V
S
A
T
Y
P
E
F
L
A
N
A
L
T
K
Y
M
R
D
P
----
T
F
V
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------