@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0296: (2015-11-30 )
MAKDIIKVDHIFKSIGQKTILEDISFSIASNQCVALIGPNGAGKTTLMSTLLGDISISSGSLTIFNLPAHHNRLKYKVAILPQENVLPSKFTVRELIDFQRCLFPEVLPMSLILDYLQWSDTHLQQFTETLSGGQKRLLAFVLTLVGKPQLLFLDEPTSGMDTSTRQRFWELIATLKKEGVTIVYSSHYIEEVEHTADRILVLHKGKLLRDTTPFAMKQEKTEKLFTVPLSYQKLLPTYLITECEAKSDSITFVTGEAEAVWKILADNGCPIEAIEMTNRTLLNRIFETTKEVKHENL
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.......-..10.....--...20........30........40........50........60.-----..----.----.-.-..70--.---..----......80.---.--..-----....90....--------..---------..------100...----.-----.-..--110-----.---------.......120--.--..--......-130--....-....-.140.......150--.........160.......170.....-..-.-180.......190.......200.......210...---.....220.......230.......240.......250.......260.......270.......280.......290......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA
K
D
I
I
K
-
V
D
H
I
F
K
S
I
G
--
Q
K
T
I
L
E
D
I
S
F
SIASN
Q
C
V
A
L
IGPNGA
G
K
T
T
L
M
S
T
L
L
G
D
I
S
ISSG
S
L
-----
T
I
----
F
----N-L-PAH---H---N
R
----
L
K
Y
K
V
A
I
LP---Q--EN-----VLP
S
K
F
T
V
R
E
--------
L
I
---------
D
F
------
Q
R
C
L
F
P
----
E
-----
V
-
L
P
--
M
S
------
L
---------
I
L
D
Y
LQW
S
----
D
--
T
H
--
L
Q
Q
F
T
E
-
T
----LSG
G
-
Q
K
R
L
-
L
A
F
V
L
T
LVGK
P
Q
----
L
L
F
L
DEPTSGMD
T
S
T
R
Q
R
F
W
E
-
L
I
A
T
L
-
K
K-E-
G
V
T
I
V
YS
S
H
Y
I
E
E
V
E
HTA
D
R
I
L
V
L
HKGKLLR-DTTP---
F
A
M
K
Q
EKTE
K
L
F
T
VP
L
S
Y
Q
K
L
L
P
T
Y
L
I
TECEAKSD
S
I
T
F
V
TG
E
A
E
A
V
W
K
I
L
ADNGCPI
E
A
I
E
MT
N
R
T
L
L
N
R
I
F
E
T
T
K
E
V
KHENL
6
PsiBlast_PDB
78.28
32%
-137
- C1 -
4G1U
1
HMUV_YERPE
C:
[11-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
-
A
S
H
L
H
Y
H
V
Q
--
Q
Q
A
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
-----
H
L
----
L
GQ--
N
-
L
-
N
S
W
---
Q
---
P
K
A
---
L
A
R
T
R
A
V
M
R
---
Q
--
Y
S
-----
E
L
A
F
P
F
S
V
S
E
--------
V
I
---------
Q
M
------
G
R
A
P
Y
G
----
G
-----
S
-
Q
D
--
R
Q
------
A
---------
L
Q
Q
V
M
A
Q
T
----
D
CL
A
L
--
A
Q
R
D
Y
R
-
V
----
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
W
Q
P
Q
P
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
-
L
L
R
Q
L
T
R
Q
-
E
-
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
-
C
G
T
P
---
E
E
V
L
N
A
E
T
L
T
Q
W
Y
Q
A
D
L
G
V
S
R
H
P
E
S
A
L
P
Q
I
Y
L
R
Q
--------------------------------------------------
21
PsiBlast_CBE
77.73
32%
-138
- C1 -
4G1U
1
HMUV_YERPE
D:
[11-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
E
-
A
S
H
L
H
Y
H
V
Q
--
Q
Q
A
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
-----
H
L
----
L
GQ--
N
-
L
-
N
S
W
---
Q
---
P
K
A---
L
A
R
T
R
A
V
M
R
---
Q
--
Y
S
-----
E
L
A
F
P
F
S
V
S
E
--------
V
I
---------
Q
M
------
G
R
A
P
Y
G
----
G
-----
S
-
Q
D
--
R
Q
------
A
---------
L
Q
Q
V
M
A
Q
T
----
D
CL
A
L
--
A
Q
R
D
Y
R
-
V
----
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
W
Q
P
Q
PTPR
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
-
L
L
R
Q
L
T
R
Q
-
E
-
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
-
C
G
T
P
---
E
E
V
L
N
A
E
T
L
T
Q
W
Y
Q
A
D
L
G
V
S
R
H
P
E
S
A
L
P
Q
I
Y
L
R
Q
--------------------------------------------------
5
PsiBlast_PDB
77.00
27%
-113
- C1 -
4HLU
2
ECFA2_THEMA
A:
[6-237]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
N
-
V
S
H
I
F
H
R
G
T
PL
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
-----
L
Y
----
D
----
G
-
E
-
R
K
K
---
G
---
Y
E
----
I
R
R
N
I
G
I
A
F
---
Q
YP
E
D
-----
Q
F
F
A
E
R
V
F
D
E
--------
V
A
---------
F
A
------
V
K
N
F
Y
P
----
D
-----
R
-
D
P
--
V
P
------
L
---------
V
K
K
A
M
E
F
V
----
G
--
L
D
--
F
D
S
F
K
D
-
R
VPFF
L
S
G
G
-
E
K
R
R
-
V
A
I
A
S
V
I
V
H
E
P
D
----
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
-
I
V
E
K
W
-
K
T
-
L
-
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
-
D
G
T
R
---
M
E
F
L
E
K
Y
D
P
R
F
F
T
S
K
M
L
V
M
R
R
L
V
L
K
G
E
D
P
F
S
M
S
D
D
E
L
L
E
R
V
C
N
-----------------------------------------
11
PsiBlast_PDB
76.58
31%
-121
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
-
I
G
H
L
S
K
S
F
Q
--
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
SGK
T
I
----
F
SKN
T
N
-
L
-
P
V
R
---
E
---
R
R
----
L
G
Y
L
V
-------
Q
--
E
G
-----
V
L
F
P
H
L
T
V
Y
R
--------
N
I
---------
A
Y
GLGNG-
K
G
R
T
A
Q
----
E
-----
R
-
Q
R
--
I
E
------
A
---------
M
L
E
L
T
G
I
S
----
E
--
L
---
A
G
R
Y
P
H
-
E
----
L
S
G
G
-
Q
Q
Q
R
-
A
A
L
A
R
A
L
A
P
D
P
E
----
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
-
R
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
-
T
A
S
P
---
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
I
V
F
P
A
A
L
N
A
D
G
T
A
D
C
R
L
G
R
L
P
V
Q
S
G
A
P
A
G
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
H
P
H
S
A
P
A
A
S
I
H
A
V
V
L
K
T
T
P
K
A
R
4
PsiBlast_PDB
76.25
27%
-109
- C1 -
2YZ2
-
ECFA2_THEMA
A:
[1-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
I
E
V
V
N
-
V
S
H
I
F
H
R
G
T
PL
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
-----
L
Y
----
D
----
G
-
E
-
R
K
K
---
G
---
Y
E
----
I
R
R
N
I
G
I
A
F
---
Q
YP
E
D
-----
Q
F
F
A
E
R
V
F
D
E
--------
V
A
---------
F
A
------
V
K
N
F
Y
P
----
D
-----
R
-
D
P
--
V
P
------
L
---------
V
K
K
A
M
E
F
V
----
G
--
L
D
--
F
D
S
F
K
D
-
R
VPFF
L
S
G
G
-
E
K
R
R
-
V
A
I
A
S
V
I
V
H
E
P
D
----
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
-
I
V
E
K
W
-
K
T
-
L
-
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
-
D
G
T
R
---
M
E
F
L
E
K
Y
D
P
R
F
F
T
S
K
M
L
V
M
R
R
L
V
L
K
G
E
D
P
F
S
M
S
D
D
E
L
L
E
R
V
C
N
S
----------------------------------------
23
PsiBlast_CBE
76.15
31%
-118
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
-
I
G
H
L
S
K
S
F
Q
--
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
SLSGK
T
I
----
F
SKNT
N
-
L
-
P
V
R
---
E
---
R
R
----
L
G
Y
L
V
-------
Q
--
E
G
-----
V
L
F
P
H
L
T
V
Y
R
--------
N
I
---------
A
Y
GLGNG-
K
G
R
T
A
Q
----
E
-----
R
-
Q
R
--
I
E
------
A
---------
M
L
E
L
T
G
I
S
----
E
--
L
---
A
G
R
Y
P
H
-
E
----
L
S
G
G
-
Q
Q
Q
R
-
A
A
L
A
R
A
L
A
P
D
P
E
----
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
-
R
A
-
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
-
T
A
S
P
---
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
G
E
G
I
V
F
P
A
A
L
N
A
D
G
T
A
D
C
R
L
G
R
L
P
V
Q
S
G
A
P
A
G
T
R
G
T
L
L
I
R
P
E
Q
Y
S
L
H
P
H
S
A
P
A
A
S
I
H
A
V
V
L
K
T
T
P
K
A
R
16
PsiBlast_PDB
75.57
30%
-97
- C1 -
1OXV
7
?
A:
[1-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
-
G
--
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
-----
Y
F
----
D
----
D
R
L
-
V
A
S
---
N
---
G
K
----
L
-----
I
V
P
---
P
--
E
D
RK
I
G
M
V
F
Q
T
W
A
L
Y
P
N
--------
L
T
---------
A
F
------
E
N
I
A
F
P
----
L
-----
T
N
M
K
--
M
S
K
E
E
I
R
K
R
---------
V
E
E
V
A
K
I
L
----
D
--
I
H
HV
L
N
H
F
P
R
-
E
----
L
S
G
G
-
Q
Q
Q
R
-
V
A
L
A
R
A
L
V
K
D
P
S
----
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
-
L
V
K
E
V
-
Q
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
-
V
G
K
P
-----------
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
52
Fugue
75.12
24%
-108
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
RVIDRAT
G
D
L
E
F
R
N
-
V
T
F
T
Y
P
G
-
R
--
E
V
P
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
-----
L
M
----
D
----
G
-
H
-
D
L
R
EYT
L
---
A
S
----
L
R
N
Q
V
A
L
V
S
---
Q
--
N
V
-----
H
L
F
N
D
-
T
V
A
N
--------
N
I
---------
A
Y
ARTEEY
S
R
E
Q
I
E
----
E
-----
A
-
A
R
--
M
A
------
Y
---------
A
M
D
F
I
N
K
M
DNGL
D
--
T
I
--
I
G
E
N
G
V
-
L
----
L
S
G
G
-
Q
R
Q
R
-
I
A
I
A
R
A
L
L
R
D
S
P
----
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
-
A
L
D
E
L
-
Q
K
-
N
-
R
T
S
L
V
I
A
-
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
-
R
G
T
H
---
S
E
L
L
A
Q
---------------------------------------------------------------
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--
14
PsiBlast_PDB
74.91
30%
-101
- C1 -
1OXT
-
?
A:
[1-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
-
G
--
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
-----
Y
F
----
D
----
D
R
L
-
V
A
S
---
N
---
G
K
----
L
-----
I
V
P
---
P
--
E
D
RK
I
G
M
V
F
Q
T
W
A
L
Y
P
N
--------
L
T
---------
A
F
------
E
N
I
A
F
P
----
L
-----
T
N
M
K
--
M
S
K
E
E
I
R
K
R
---------
V
E
E
V
A
K
I
L
----
D
--
I
H
HV
L
N
H
F
P
R
-
E
----
L
S
G
G
-
Q
Q
Q
R
-
V
A
L
A
R
A
L
V
K
D
P
S
----
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
-
L
V
K
E
V
-
Q
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
-
V
G
K
P
-----------
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
15
PsiBlast_PDB
74.87
30%
-96
- C1 -
1OXU
7
?
A:
[1-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
-
G
--
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
-----
Y
F
----
D
----
D
R
L
-
V
A
S
---
N
---
G
K
----
L
-----
I
V
P
---
P
--
E
D
RK
I
G
M
V
F
Q
T
W
A
L
Y
P
N
--------
L
T
---------
A
F
------
E
N
I
A
F
P
----
L
-----
T
N
M
K
--
M
S
K
E
E
I
R
K
R
---------
V
E
E
V
A
K
I
L
----
D
--
I
H
HV
L
N
H
F
P
R
-
E
----
L
S
G
G
-
Q
Q
Q
R
-
V
A
L
A
R
A
L
V
K
D
P
S
----
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
-
L
V
K
E
V
-
Q
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
-
V
G
K
P
-----------
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
17
PsiBlast_PDB
74.86
31%
-124
- C1 -
4HUQ
-
ECFA2_LACBA
A:
[21-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
L
T
D
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
T
I
-----
K
I
DE--
F
----
T
-
I
T
P
E
T
---
T
---
N
A
AL
K
P
L
R
Q
H
V
G
M
V
F
---
Q
FP
E
N
-----
Q
L
F
E
E
-
T
V
R
Q
--------
D
I
---------
A
F
------
G
----
P
----
K
-----
N
-
F
G
--
M
A
------
D
A
D
A
L
A
L
A
D
E
M
L
T
T
V
G
L
D
----
Q
--
S
Y
--
A
E
R
S
P
F
-
E
----
L
S
G
G
-
Q
M
R
R
-
V
A
I
A
G
V
L
A
M
Q
P
K
----
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
-
L
F
A
R
L
-
H
Q
-
E
Q
G
L
T
I
V
L
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
H
E
G
R
L
M
K
-
F
G
T
P
A
D
V
F
S
N
R
E
W
L
Q
D
H
Q
L
D
V
P
Q
A
A
Q
F
A
R
R
L
R
D
R
G
L
T
F
P
K
Q
P
L
T
A
D
Q
L
A
D
Y
L
A
Q
Q
W
A
Q
R
--------------------------------
13
PsiBlast_PDB
74.48
30%
-98
- C1 -
1OXS
20
?
C:
[1-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
-
G
--
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
-----
Y
F
----
D
----
D
R
L
-
V
A
S
---
N
---
G
K
----
L
-----
I
V
P
---
P
--
E
D
RKIGM
V
F
Q
T
W
A
L
Y
P
N
--------
L
T
---------
A
F
------
E
N
I
A
F
P
----
L
-----
T
N
M
K
--
M
S
KEEIRK
R
---------
V
E
E
V
A
K
I
L
----
D
--
I
H
HV
L
N
H
F
P
R
-
E
----
L
S
G
G
-
Q
Q
Q
R
-
V
A
L
A
R
A
L
V
K
D
P
S
----
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
-
L
V
K
E
V
-
Q
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
-
V
G
K
P
-----------
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
19
PsiBlast_PDB
74.10
30%
-99
- C1 -
1OXX
23
?
K:
[1-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
-
G
--
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
-----
Y
F
----
D
----
D
R
L
-
V
A
S
---
N
---
G
K
----
L
-----
I
V
P
---
P
--
E
D
RKIGM
V
F
Q
T
W
A
L
Y
P
N
--------
L
T
---------
A
F
------
E
N
I
A
F
P
----
L
-----
T
N
M
K
--
M
S
KEEIRK
R
---------
V
E
E
V
A
K
I
L
----
D
--
I
H
HV
L
N
H
F
P
R
-
E
----
L
S
G
A
-
Q
Q
Q
R
-
V
A
L
A
R
A
L
V
K
D
P
S
----
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
-
L
V
K
E
V
-
Q
S
-
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
-
V
G
K
P
-----------
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
K
V
2
PsiBlast_PDB
70.54
31%
-118
- C1 -
1VPL
2
?
A:
[18-235]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
D
L
R
K
R
I
G
--
K
K
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
-----
T
V
----
F
GK--
N
-
V
-
V
E
E
---
P
---
H
E
----
V
R
K
L
I
S
Y
L
P
---
E
--
E
A
-----
G
A
Y
R
N
M
Q
G
I
E
--------
Y
L
---------
R
F
------
V
A
G
F
Y
A
SS
S
S
E
-----
I
-
E
E
--
M
V
------
E
---------
R
A
T
E
I
A
G
L
----
G
--
E
K
--
I
K
D
R
V
S
-
T
----
Y
S
K
G
-
M
V
R
K
-
L
L
I
A
R
A
L
M
V
N
P
R
----
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
-
I
L
K
Q
A
-
S
Q
-
E
-
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
-
T
G
T
V
---
E
E
L
K
E
R
Y
K
A
Q
N
I
E
E
V
F
E
E
V
V
K
---------------------------------------------------------------
7
PsiBlast_PDB
70.42
27%
-106
- C1 -
4ZIR
5
ECFA2_THEMA
A:
[5-236]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
V
N
-
V
S
H
I
F
H
R
G
T
PL
E
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
-----
L
Y
----
D
----
G
-
E
---
K
---
G
---
Y
E
----
I
R
R
N
I
G
I
A
F
---
Q
YP
E
D
-----
Q
F
F
A
E
R
V
F
D
E
--------
V
A
---------
F
A
------
V
K
N
F
Y
P
----
D
-----
R
-
D
P
--
V
P
------
L
---------
V
K
K
A
M
E
F
V
----
G
--
L
D
--
F
D
S
F
K
D
-
R
VPFF
L
S
G
G
-
E
K
R
R
-
V
A
I
A
S
V
I
V
H
E
P
D
----
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
-
I
V
E
K
W
-
K
T
-
L
-
G
K
T
V
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
V
V
L
E
K
G
K
K
V
F
-
D
G
T
R
---
M
E
F
L
E
K
Y
D
P
R
F
F
T
S
K
M
L
V
M
R
R
L
V
L
K
G
E
D
P
F
S
M
S
D
D
E
L
L
E
R
V
C
N
-----------------------------------------
18
PsiBlast_PDB
70.10
31%
-116
- C1 -
4HZU
-
ECFA2_LACBA
B:
[21-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
L
T
D
V
S
L
T
V
P
D
R
G
Y
L
A
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
A
L
L
K
P
T
S
G
T
I
-----
K
I
DE--
F
----
T
-
I
T
P
E
T
---
T
---
N
A
ALKP
L
R
Q
H
V
G
M
V
F
---
Q
FP
E
N
-----
Q
L
F
E
E
-
T
V
R
Q
--------
D
I
---------
A
F
------
G
----
P
----
K
-----
N
-
F
G
--
M
A
------
D
A
D
A
L
A
L
A
D
E
M
L
T
T
V
G
L
D
----
Q
--
S
Y
--
A
E
R
S
P
F
-
E
----
L
S
G
G
-
Q
M
R
R
-
V
A
I
A
G
V
L
A
M
Q
P
K
----
V
L
V
L
D
E
P
T
A
G
L
D
P
Q
G
R
Q
E
M
M
R
-
L
F
A
R
L
-
H
Q
-
E
Q
G
L
T
I
V
L
V
T
H
Q
M
E
D
V
A
Q
Y
A
E
Q
V
A
V
M
H
E
G
R
L
M
K
-
F
G
T
P
A
D
V
F
S
N
R
E
W
L
Q
D
H
Q
L
D
V
P
Q
A
A
Q
F
A
R
R
L
R
D
R
G
L
T
F
P
K
Q
P
L
T
A
D
Q
L
A
D
Y
L
A
Q
Q
W
A
Q
R
--------------------------------
10
PsiBlast_PDB
69.69
27%
-140
- C1 -
4WBS
1
?
A:
[42-262]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
N
L
K
K
R
Y
G
--
S
R
T
V
V
K
D
V
S
L
D
V
K
S
G
E
V
V
G
L
L
G
P
N
G
A
G
K
T
T
S
F
Y
M
I
V
G
L
V
P
L
D
A
G
E
I
-----
D
L
DGKS
I
----
S
-
L
-
L
P
I
---
H
---
K
R
----
A
S
L
G
L
S
Y
L
P
---
Q
--
E
A
-----
S
V
F
R
K
L
S
V
E
E
--------
N
I
R
A
V
L
E
L
QVG
D
D
------
G
K
R
L
S
K
----
D
-----
A
-
I
A
S
R
T
E
------
A
---------
L
L
D
E
L
Q
I
S
--------
H
--
L
R
E
N
P
A
L
S
----
L
S
G
G
-
E
R
R
R
-
V
E
I
A
R
A
L
A
T
N
P
S
----
F
I
L
L
D
E
P
F
A
G
V
D
P
I
A
V
L
E
I
Q
K
-
I
V
K
F
L
-
K
Q
-
R
-
N
I
G
V
L
I
T
D
H
N
V
R
E
T
L
G
I
C
D
H
A
Y
I
I
S
D
G
S
V
L
A
-
A
G
A
P
---
G
D
I
I
E
N
E
S
V
R
R
V
Y
L
G
E
H
F
R
M
----------------------------------------------------------------
45
HHSearch
69.55
26%
-128
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-222]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
I
L
R
-
A
E
N
I
K
K
V
I
R
--
G
Y
E
I
L
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
-----
F
L
----
E
----
G
-
K
-
E
V
D
---
Y
TN
E
K
E
L
S
L
L
R
N
R
K
L
G
F
V
F
---
Q
--
F
H
-----
Y
L
I
P
E
L
T
A
L
E
--------
N
V
---------
I
V
------
P
M
L
K
M
G
----
K
P
K
K
E
A
K
-
E
R
--
G
E
------
Y
---------
L
L
S
E
L
G
L
G
----
D
--
K
---
L
S
R
K
P
Y
-
E
----
L
S
G
G
-
E
Q
Q
R
-
V
A
I
A
R
A
L
A
N
E
P
I
----
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
-
I
F
L
K
I
-
N
E
-
G
-
G
T
S
I
V
M
V
T
H
E
R
E
L
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
V
G
-
E
I
T
R
---
V
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
69.55
29%
-112
- C1 -
4HZI
1
?
A:
[42-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
P
T
G
---
K
T
I
L
D
S
V
S
F
E
I
K
T
N
E
H
C
V
L
L
G
R
N
G
A
G
K
S
T
L
V
N
L
I
Y
G
M
I
W
A
T
S
G
T
I
-----
R
L
----
F
----
Q
-
E
-
T
Y
G
---
E
IA
I
Q
D
----
L
R
K
R
I
G
I
L
D
SSQ-------------
R
K
L
T
V
K
D
T
I
L
T
G
LFH
T
I
---------
G
Y
------
Y
R
D
P
S
P
----
E
-----
E
-
E
T
--
K
T
------
L
---------
Q
I
--
L
K
D
S
----
D
LL
S
K
--
K
D
Q
L
Y
N
-
T
----
L
S
S
G
-
E
K
K
K
-
I
L
F
L
R
S
I
V
N
E
P
D
----
F
L
I
M
D
E
P
C
S
S
L
D
L
T
A
R
E
D
F
L
G
-
F
L
K
E
Y
H
S
K
-
K
-
K
F
T
S
L
Y
I
T
H
R
P
E
E
I
P
D
F
Y
S
K
A
V
L
L
K
E
G
K
V
I
H
F
G
P
I
E
---
E
C
F
T
E
K
N
L
E
D
L
Y
D
I
P
L
Q
V
Q
R
I
E
N
T
W
S
V
I
P
K
Q
-----------------------------------------------------
28
HHSearch
68.85
30%
-117
- C1 -
2IT1
-
?
A:
[2-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
I
K
-
L
E
N
I
V
K
K
F
G
--
N
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
-----
Y
F
----
D
----
E
-
K
-
D
V
T
---
E
L--
P
P
----
K
D
R
N
V
G
L
V
F
---
Q
--
N
W
-----
A
L
Y
P
H
M
T
V
Y
K
--------
N
I
---------
A
F
------
P
L
E
L
R
K
----
A
P
R
E
E
I
D
-
K
K
--
V
R
------
E
---------
V
A
K
M
L
H
I
D
----
K
--
L
---
L
N
R
Y
P
W
-
Q
----
L
S
G
G
-
Q
Q
Q
R
-
V
A
I
A
R
A
L
V
K
E
P
E
----
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
-
E
L
K
R
L
-
Q
K
E
L
-
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
-
V
G
T
P
---
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
M
N
F
V
E
A
K
V
E
D
G
K
L
V
I
T
E
K
S
K
L
P
I
P
K
Q
Y
V
E
I
V
K
E
T
G
I
T
E
V
I
I
G
F
R
P
H
D
A
E
I
V
K
G
E
G
E
G
I
V
G
E
V
Y
S