@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0307: (2015-11-30 )
MIQIGKLFAGRYRILKSIGRGGMADVYLARDLILDNEEVAIKVLRTNYQTDQIAVARFQREARAMAELTHPNIVAIRDIGEEDGQQFLVMEYVDGFDLKKYIQDNAPLSNNEVVRIMNEVLSAMSLAHQKGIVHRDLKPQNILLTKKGTVKVTDFGIAVAFAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSILAENKSVPQALENIVIKATAKKLTDRYKTTYEMGRDLSTALSSTRHREPKLVFNDTESTKTLPKVTSTVSSLTTEQLLRNQKQAKTTEKITPDSASNDKTKSKKKASHRLLGTIMKLFFALCVVGIIVFAYKILVSPTTIRVPDVSNKTVAQAKMTLENSGLKVGAIRNIESDSVSEGLVVKTDPAAGRSRREGAKVNLYIATPNKSFTLGNYKEHNYKDILKDLQGKGVKKSLIKVKRKINNDYTTGTILAQSLPEGTSFNPDGNKKLTLTVAVNDPMIMPDVTGMTVGEVIETLTDLGLDADNLVFYQMQNGVYQAVVTPPSSSKIASQDPYYGGEVGLRRGDKVKLYLLGSKTTNNSSSTPIDSSASSSTGTTTSDSVSSSTDASTSDSSSTSTSSSTLPSDSTTNTGTANNPLTQ
Atome Classification :
(20 SA)
.........10........20........30........40........50----.........60.......-.70........80--.....----...90........100..--.-....110.......120.......130.......140.......150.......160.....-..170.......180....------...-190.......200.....-..210.......220.....-..230...-....240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIQ
I
G
K
L
F
A
G
R
Y
R
I
L
K
S
IGRGGM
A
D
V
Y
L
A
R
D
LILDNE
E
V
A
I
K
V
L
RTNYQ
T
-----
D
Q
I
A
V
A
R
F
Q
R
E
A
R
A
M
A
E
L-THP
N
I
V
A
I
RDI
G
E
--EDG
Q
Q
----
F
L
V
M
EYVDG
F
D
L
K
K
Y
I
QD--N-APLS
N
N
E
V
V
R
I
M
N
E
V
L
S
A
M
S
L
A
H
QKGIVHRDLKPQ
N
I
L
L
TKKG
T
V
K
V
T
DF
G
I
A
V
A
F
AETSLT-
Q
T
N
S
MLGSVHYL
S
P
E
QARG------SKA-
T
V
Q
S
D
I
Y
A
M
G
I
M
L
F
E
M
L
T-GHIPYDGD
S
A
V
T
I
A
L
Q
H
F
QK-P
L
P
S
I
L
AE-NKS
V
P
Q
A
L
E
N
I
V
I
K
A
T
A
K
K
L
T
D
R
Y
K
T
T
Y
E
MG
R
D
L
S
T
A
L
S
STRHREP
K
L
V
FNDTESTKTL
P
K
V
T
S
T
V
S
S
L
T
T
E
Q
L
L
R
N
Q
K
QAKTTEKITPDSASNDKTK
S
K
K
K
A
S
H
R
L
L
G
T
I
M
K
L
F
F
A
L
C
V
V
G
I
I
V
F
A
Y
K
I
LVSP
T
T
I
RVPDVSNK
T
V
A
Q
A
K
M
T
LENSG
L
K
V
G
A
I
RNIESDSVSE
G
L
V
V
KTDPAAGRSRREG
A
K
V
N
L
Y
I
ATPNK
S
F
TLGNYKEH
N
Y
K
D
I
L
K
D
L
QGK
G
V
K
K
S
L
I
K
V
K
R
K
INNDYT
T
G
T
I
L
A
Q
SLPEGTSFNPDGN
K
K
L
T
L
T
V
AVND
P
M
IMPDVTGM
T
V
G
E
V
I
E
T
L
T
DLGLDAD
N
L
V
F
Y
Q
MQNG
V
Y
Q
A
V
VTPPSSSKIASQDPYYGGEVGLRRG
D
K
V
K
L
Y
L
L
GSKTTNNSSSTPIDSSASSSTGTTTSDSVSSSTDASTSDSSSTSTSSSTLPSDSTTNTGTANNPLTQ
22
PsiBlast_CBE
88.42
45%
-97
- C1 -
4EQM
1
?
E:
[5-281]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
-
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
--
H
-
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
----------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
-
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
-
S
V
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
87.64
45%
-98
- C1 -
4EQM
1
?
D:
[5-281]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
-
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
--
H
-
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
----------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
-
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
-
S
V
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.63
45%
-96
- C1 -
4EQM
1
?
F:
[5-281]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
-
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
--
H
-
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
----------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
-
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
-
S
V
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.04
45%
-94
- C1 -
4EQM
2
?
C:
[5-281]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
-
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
--
H
-
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
A
L
--------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
-
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
-
S
V
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
83.41
45%
-94
- C1 -
4EQM
2
?
B:
[5-281]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
-
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
--
H
-
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
A
L
--------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
-
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
-
S
V
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
82.42
42%
-91
- C1 -
2FUM
1
PKNB_MYCTU
C:
[30-293]
----------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
-
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
--
E
-
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
---------------------
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
-
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
81.92
45%
-93
- C1 -
4EQM
2
?
A:
[5-281]
---
I
G
K
I
I
N
E
R
Y
K
I
V
D
K
L
G
G
G
G
M
S
T
V
Y
L
A
E
D
T
I
L
-
N
I
K
V
A
I
K
A
I
F
I
P
P
R
E
-----
K
E
E
T
L
K
R
F
E
R
E
V
H
N
S
S
Q
L
-
S
H
Q
N
I
V
S
M
I
D
V
D
E
--
E
D
D
C
Y
----
Y
L
V
M
E
Y
I
E
G
P
T
L
S
E
Y
I
E
S
--
H
-
G
P
L
S
V
D
T
A
I
N
F
T
N
Q
I
L
D
G
I
K
H
A
H
D
M
R
I
V
H
R
D
I
K
P
Q
N
I
L
I
D
S
N
K
T
L
K
I
F
D
F
G
I
A
K
A
L
--------------
T
V
Q
Y
F
S
P
E
Q
A
K
G
------
E
A
T
-
D
E
C
T
D
I
Y
S
I
G
I
V
L
Y
E
M
L
V
-
G
E
P
P
F
N
G
E
T
A
V
S
I
A
I
K
H
I
Q
D
-
S
V
P
N
V
T
T
D
V
R
K
D
I
P
Q
S
L
S
N
V
I
L
R
A
T
E
K
D
K
A
N
R
Y
K
T
I
Q
E
M
K
D
D
L
S
S
V
L
H
E
N
R
A
N
E
D
V
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.45
42%
-91
- C1 -
1O6Y
3
PKNB_MYCTU
A:
[30-293]
----------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
-
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
--
E
-
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
---------------
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
-
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.48
42%
-87
- C1 -
2FUM
1
PKNB_MYCTU
A:
[30-293]
----------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
-
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
--
E
-
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
D
-----------
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
-
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
80.30
40%
-80
- C1 -
3ORK
3
?
A:
[13-293]
----------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
-
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
--
E
-
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
-----------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
-
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-
V
L
T
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.14
40%
-79
- C1 -
3ORO
2
?
A:
[13-291]
----------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
-
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
--
E
-
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
-------
T
A
A
V
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
-
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-
V
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
78.36
40%
-76
- C1 -
3ORT
2
?
A:
[13-292]
----------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
-
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
--
E
-
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
R
-----------------
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
-
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-
V
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.34
40%
-80
- C1 -
3F61
5
PKNB_MYCTU
A:
[13-293]
----------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
-
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
--
E
-
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
------------------
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
-
G
E
P
P
F
T
G
D
S
P
D
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-
V
L
T
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.75
40%
-74
- C1 -
3ORP
1
?
A:
[13-293]
----------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
-
R
D
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
-
N
H
P
A
I
V
A
V
Y
D
T
G
E
--
A
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
--
E
-
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
---------------
I
G
T
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
-
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-
V
L
T
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
75.87
40%
-86
- C1 -
3ORM
2
?
A:
[13-292]
----------
R
Y
E
L
G
E
I
L
G
F
G
G
M
S
E
V
H
L
A
R
D
L
R
L
-
H
R
D
V
A
V
K
V
L
R
A
D
L
A
R
-----
D
P
S
F
Y
L
R
F
R
R
E
A
Q
N
A
A
A
L
-
N
H
P
A
I
V
A
V
Y
A
T
G
E
--
A
E
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
V
T
L
R
D
I
V
H
T
--
E
-
G
P
M
T
P
K
R
A
I
E
V
I
A
D
A
C
Q
A
L
N
F
S
H
Q
N
G
I
I
H
R
D
V
K
P
A
N
I
M
I
S
A
T
N
A
V
K
V
M
D
F
G
I
A
R
A
I
A
-------------
T
A
Q
Y
L
S
P
E
Q
A
R
G
------
D
S
V
-
D
A
R
S
D
V
Y
S
L
G
C
V
L
Y
E
V
L
T
-
G
E
P
P
F
T
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
S
-
A
R
-
H
E
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
N
P
E
N
R
Y
Q
T
A
A
E
M
R
A
D
L
V
R
V
H
N
G
E
P
P
E
A
P
K
-
V
L
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
65.25
24%
-78
- C1 -
3CBL
4
A:
[113-374]
--------
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
D
N
-
T
L
V
A
V
K
S
C
R
E
T
L
P
-------
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
--
Q
K
Q
P
I
----
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
--
E
G
A
R
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
------
G
R
Y
-
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
G
-
G
R
L
---
P
C
-
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
-
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.22
39%
-87
- C1 -
4OW8
2
PKNA_MYCTU
A:
[4-232]
--
R
V
G
V
T
L
S
G
R
Y
R
L
Q
R
L
I
A
T
G
G
M
G
Q
V
W
E
A
V
D
N
R
L
-
G
R
R
V
A
V
K
V
L
K
S
E
F
S
S
-----
D
P
E
F
I
E
R
F
R
A
E
A
R
T
T
A
M
L
-
N
H
P
G
I
A
S
V
H
D
Y
G
E
S
Q--
R
T
A
----
Y
L
V
M
E
L
V
N
G
E
P
L
N
S
V
L
K
R
--
T
-
G
R
L
S
L
R
H
A
L
D
M
L
E
Q
T
G
R
A
L
Q
I
A
H
A
A
G
L
V
H
R
D
V
K
P
G
N
I
L
I
T
P
T
G
Q
V
K
I
T
D
F
G
I
A
K
A
V
D
A
A
P
V
T
-
Q
T
G
M
V
M
G
T
A
Q
Y
I
A
P
E
Q
A
L
G
------
H
D
A
-
S
P
A
S
D
V
Y
S
L
G
V
V
G
Y
E
A
V
S
-
G
K
R
P
F
A
G
D
G
A
L
T
V
A
M
K
H
I
K
E
-
P
P
P
P
L
P
P
D
-
L
P
P
N
V
R
E
L
I
E
I
T
L
V
K
N
P
A
M
R
Y
R
S
G
G
P
F
A
D
A
V
A
A
V
R
A
G
R
R
P
P
R
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
63.71
24%
-73
- C1 -
2Y7J
1
PHKG2_HUMAN
A:
[92-360]
-------
F
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
G
-
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
--
S
S
S
F
M
----
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
--
K
-
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
D
D
N
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
G
--
E
-
K
L
R
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
K
C
S
M
D
ETH
P
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
-
G
S
P
P
F
W
H
R
R
Q
I
L
M
L
R
M
I
M
E
G
-
Q
Y
Q
F
S
S
P
E
-
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
-
A
E
Q
A
L
Q
H
P
F
F
E
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
63.23
29%
-72
- C1 -
3FE3
-
MARK3_HUMAN
A:
[52-304]
-------
H
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
-
R
E
V
A
I
K
I
I
D
K
T
Q
L
------
N
P
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
--
T
E
K
T
L
----
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
--
H
-
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
M
N
I
K
I
A
D
F
G
F
S
N
E
F
T
V
G
--
G
-
K
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
------
K
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
R
----
I
-
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
-
L
E
Q
I
M
K
D
R
W
I
N
A
G
H
E
E
D
E
L
K
P
F
V
E
P
E
L
D
I
S
D
Q
K
R
I
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
I
T
A
T
Y
L
L
L
G
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Fugue
59.92
24%
-87
- C1 -
1BYG
1
CSK_HUMAN
A:
[15-276]
---
G
W
A
L
N
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G
---
N
K
V
A
V
K
C
I
K
------------
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
-
R
H
S
N
L
V
Q
L
L
G
V
I
V
----
E
E
G
L---
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
R
-
S
V
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
N
V
A
K
V
S
D
F
G
-----------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
------
K
K
F
-
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
I
P
L
-
K
D
V
V
P
R
V
E
K
-
G
Y
K
--
M
D
A
-
P
D
G
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
-
P
S
F
L
Q
L
R
E
Q
L
E
H
I
K
T
H
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------