@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0333: (2015-11-30 )
MKTRITELLNIKYPIFQGGMAWVADGDLAGAVSKAGGLGIIGGGNAPKEVVKANIDKIKSMTDKPFGVNIMLLSPFVDDIVDLVIEEGVKVVTTGAGNPGKYMERFHEAGITVIPVVPSVALAKRMEKLGADAIITEGMEAGGHIGKLTTMTLVRQVVDAVTIPVIAAGGIADGRGAAAGFMLGADAVQVGTRFVVAKESNAHPNYKAKILKAKDIDTAVSAQVVGHPVRALKNKLVTTYSQAEKDYLAGRISINEIEELGAGALRNAVVDGDVINGSVMAGQIAGLIKSEETCQEILEDIYSGARQVILSEASRWSDL
Atome Classification :
(20 SA)
-.........10........20........30........40....-..-.-.50........60........70...-----.------------------------------------....--80........90........100.......-110.......120.......130.......140....---------.--..150.......160.......170.......180.......190.......200.......210.......220.......230.......240.....-..250.....-..-260-.......270.......280.......290.......300.......310.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MK
T
R
I
T
E
L
LNIKY
P
I
FQG
G
M
A
W
VADGD
L
A
G
A
V
SKAG
G
L
G
I
IGGGN-
A
P
-
K
-
E
V
V
K
A
N
I
D
K
I
K
S
MTDKPF
G
V
N
I
M
L
L
S
-----
P
------------------------------------
F
V
D
D
--
I
V
D
L
V
I
EEG
V
K
V
V
T
TGAGN
P
G
K
Y
M
E
R
F
H
EA-G
I
T
V
I
PVV
P
S
V
A
L
A
K
R
M
E
K
LGA
D
A
I
I
T
E
G
M
EAGGHIG---------
K
--
L
T
T
M
T
L
V
R
Q
V
V
D
A
VT
I
P
V
I
AAGGIADGRGAAA
G
F
M
LG
A
D
A
V
QVG
T
R
F
V
V
A
KESNAHPNY
K
A
K
I
L
KAKDI
D
T
A
V
S
A
Q
V
VG
H
P
V
R
A
L
K
N
K
L
V
T
T
Y
S
Q
A
E
K
D
Y
-LAGRI
S
I
N
E
I
-
E
E
-
L
G
A
-
G
A
L
R
NAVVDGDVING
S
V
M
A
G
Q
I
A
G
L
IK
S
E
E
T
C
Q
E
I
L
E
D
I
Y
S
G
A
R
Q
V
I
L
S
E
A
S
RWSDL
21
PsiBlast_CBE
91.69
80%
-104
- C3 -
2Z6J
4
?
B:
[1-318]
-
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
P
-
K
-
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
-----
P
------------------------------------
F
V
E
D
--
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
S
K
Y
M
E
R
F
H
E
A
-
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
--
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
----
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
-
F
----------
E
Q
-
M
G
A
-
G
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
56
HHSearch
91.49
80%
-103
* C3 *
2Z6I
5
?
A:
[1-318]
-
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
P
-
K
-
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
-----
P
------------------------------------
F
V
E
D
--
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
S
K
Y
M
E
R
F
H
E
A
-
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
--
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
F
K
Q
---
D
L
E
I
F
-
E
Q
-
M
G
A
-
G
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
1
PsiBlast_PDB
91.04
80%
-105
- C3 -
2Z6J
5
?
A:
[1-318]
-
M
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
P
-
K
-
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
-----
P
------------------------------------
F
V
E
D
--
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
S
K
Y
M
E
R
F
H
E
A
-
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
--
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
---
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
-
F
----------
E
Q
-
M
G
A
-
G
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
2
PsiBlast_PDB
89.64
78%
-103
- C3 -
2Z6I
5
?
A:
[2-318]
--
K
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
-
A
P
-
K
-
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
-----
P
------------------------------------
F
V
E
D
--
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
S
K
Y
M
E
R
F
H
E
A
-
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
---------
K
--
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
R
D
I
D
T
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
-
F
K
Q
---
D
L
E
I
F
E
Q
-
M
G
A
-
G
A
L
A
K
A
V
V
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
K
I
Q
E
E
A
S
R
W
T
G
V
3
PsiBlast_PDB
78.42
50%
-99
- C3 -
3BO9
13
?
A:
[15-317]
-
V
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
-
M
K
-
P
-
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
V
S
-----
P
------------------------------------
W
A
D
D
--
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
T
K
Y
I
R
E
L
K
E
N
-
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
---------
E
--
V
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
F
E
-------
N
P
M
Q
A
-
E
E
-
M
L
V
-
G
S
L
R
R
A
V
V
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
V
E
K
L
R
G
Y
I
E
--
57
HHSearch
77.85
51%
-99
- C3 -
3BO9
13
?
A:
[16-324]
--
R
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
-
M
K
-
P
-
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
V
S
-----
P
------------------------------------
W
A
D
D
--
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
T
K
Y
I
R
E
L
K
E
N
-
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
---------
E
--
V
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
S
I
R
D
T
V
V
T
G
A
K
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
F
E
N
-
P
--
M
----
Q
A
-
E
E
-
M
L
V
-
G
S
L
R
R
A
V
V
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
V
E
K
L
R
G
Y
I
E
--
4
PsiBlast_PDB
76.61
44%
-95
- C3 -
4IQL
7
?
A:
[22-326]
---
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
A
G
S
-
M
H
-
P
-
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
P
L
L
Y
-----
P
------------------------------------
E
M
D
K
--
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
K
V
W
T
A
K
L
K
A
A
-
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
---------
R
EE
T
T
T
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
S
L
K
A
V
S
-
P
T
R
L
L
K
N
K
F
Y
Q
D
V
F
A
A
E
Q
R
-----
G
A
S
V
E
E
L
-
R
E
L
L
G
R
-
G
R
A
K
Q
G
I
F
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
S
L
A
G
M
P
T
E
I
---
22
PsiBlast_CBE
75.23
44%
-94
- C3 -
4IQL
6
?
B:
[22-326]
---
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
A
G
S
-
M
H
-
P
-
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
P
L
L
Y
-----
P
------------------------------------
E
M
D
K
--
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
K
V
W
T
A
K
L
K
A
A
-
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
---------
R
EE
T
T
T
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
V
E
G
D
T
M
L
S
L
K
A
V
S
-
P
T
R
L
L
K
N
K
F
Y
Q
D
V
F
A
A
E
Q
R
-----
G
A
S
V
E
E
L
-
R
E
L
L
G
R
-
G
R
A
K
Q
G
I
F
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
S
L
A
G
M
P
T
E
I
---
6
PsiBlast_PDB
70.49
35%
-85
- C3 -
2GJN
2
2NPD_PSEAE
A:
[4-317]
-
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
-
Q
P
-
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
TQKPV
P
------------------------------------
Y
A
E
---
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
G
E
H
I
A
E
F
R
R
H
-
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
DD
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
A
R
G
-
G
A
G
Y
A
D
I
A
A
L
-
V
S
-
G
Q
R
-
G
--
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
-
5
PsiBlast_PDB
69.90
35%
-87
- C3 -
2GJL
1
2NPD_PSEAE
A:
[4-317]
-
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
-
Q
P
-
S
P
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
TQKPV
P
------------------------------------
Y
A
E
---
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
G
E
H
I
A
E
F
R
R
H
-
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
DD
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
A
R
G
-
G
A
G
Y
A
D
I
A
A
L
-
V
S
-
G
Q
R
-
G
--
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
-
58
HHSearch
69.64
35%
-89
- C3 -
2GJL
1
2NPD_PSEAE
A:
[4-325]
-
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
Q
P
S
-
P
-
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
-----
T
QKPV--------------------------------
P
Y
A
E
--
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
G
E
H
I
A
E
F
R
R
H
-
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
DD
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
A
R
G
-
G
A
G
Y
---
A
D
I
-
A
A
-
L
V
S
G
Q
R
G
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
-
79
Fugue
68.60
34%
-88
- C3 -
2GJL
1
2NPD_PSEAE
A:
[3-326]
V
F
R
T
R
F
T
E
T
F
G
V
E
H
P
I
M
Q
G
G
M
Q
W
V
G
R
A
E
M
A
A
A
V
A
N
A
G
G
L
A
T
L
S
A
L
T
-
Q
P
S
P
-
E
A
L
A
A
E
I
A
R
C
R
E
L
T
D
R
P
F
G
V
N
L
T
L
L
P
TQKP-
V
------------------------------------
P
Y
A
E
--
Y
R
A
A
I
I
E
A
G
I
R
V
V
E
T
A
G
N
D
P
G
E
H
I
A
E
F
R
R
H
-
G
V
K
V
I
H
K
C
T
A
V
R
H
A
L
K
A
E
R
L
G
V
D
A
V
S
I
D
G
F
E
C
A
G
H
P
G
---------
E
DD
I
P
G
L
V
L
L
P
A
A
A
N
R
L
R
V
P
I
I
A
S
G
G
F
A
D
G
R
G
L
V
A
A
L
A
L
G
A
D
A
I
N
M
G
T
R
F
L
A
T
R
E
C
P
I
H
P
A
V
K
A
A
I
R
A
A
D
E
R
S
T
D
L
I
M
R
S
L
R
N
T
A
R
V
A
R
N
A
I
S
Q
E
V
L
A
I
E
A
R
G
-
G
A
G
Y
A
D
I
--
A
-
A
L
-
V
S
G
-
Q
R
G
R
Q
V
Y
Q
Q
G
D
T
D
L
G
I
W
S
A
G
M
V
Q
G
L
I
D
D
E
P
A
C
A
E
L
L
R
D
I
V
E
Q
A
R
Q
L
V
R
Q
R
L
E
G
M
L
A
-
7
PsiBlast_PDB
57.83
32%
-89
- C3 -
4Q4K
1
?
A:
[1-285]
-
M
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
A
-
A
-
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
-----
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLS
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
VFEPERGDA
A
--
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
-
L
P
D
Y
P
F
V
Y
D
A
-
T
K
-
A
L
Q
-
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
R
G
----------------
8
PsiBlast_PDB
57.32
32%
-93
- C3 -
4QIS
1
?
A:
[9-290]
----
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
A
-
A
-
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
-----
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLS
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
VFEPERGDA
A
--
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
-
L
P
D
Y
P
F
V
Y
D
A
-
T
K
-
A
L
Q
-
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
------------------
25
PsiBlast_CBE
57.30
32%
-91
- C3 -
4QIT
2
?
B:
[8-291]
--
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
A
-
A
-
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
-----
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLS
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
VFEPERGDA
A
--
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
-
L
P
D
Y
P
F
V
Y
D
A
-
T
K
-
A
L
Q
-
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
R
-----------------
10
PsiBlast_PDB
56.80
32%
-91
- C3 -
4QIU
2
?
A:
[9-290]
----
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
A
-
A
-
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
-----
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLS
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
VFEPERGDA
A
--
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
-
L
P
D
Y
P
F
V
Y
D
A
-
T
K
-
A
L
Q
-
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
R
G
----------------
26
PsiBlast_CBE
56.73
32%
-93
- C3 -
4QIU
2
?
B:
[9-290]
----
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
A
-
A
-
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
-----
P
GQADPARERAWLDYLKPLFAEFGAEPPVRLKNIYLS
F
L
E
D
PT
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
VFEPERGDA
A
--
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
-
L
P
D
Y
P
F
V
Y
D
A
-
T
K
-
A
L
Q
-
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
R
G
----------------
23
PsiBlast_CBE
56.24
32%
-88
- C3 -
4Q4K
1
?
B:
[2-285]
--
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
A
-
A
-
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
-----
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLS
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
VFEPERGDA
A
--
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
-
L
P
D
Y
P
F
V
Y
D
A
-
T
K
-
A
L
Q
-
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
R
G
----------------
24
PsiBlast_CBE
55.96
32%
-91
- C3 -
4QIS
1
?
B:
[9-290]
----
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
A
-
A
-
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
-----
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLS
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
VFEPERGDA
A
--
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
-
L
P
D
Y
P
F
V
Y
D
A
-
T
K
-
A
L
Q
-
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
R
-----------------
9
PsiBlast_PDB
55.90
32%
-88
- C3 -
4QIT
2
?
A:
[7-291]
-
M
T
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
-
S
A
-
A
-
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
-----
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
GAEPPVRLKNIYLS
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
VFEPERGDA
A
--
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
-
L
P
D
Y
P
F
V
Y
D
A
-
T
K
-
A
L
Q
-
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
E
L
L
R
T
L
V
E
E
L
R
-----------------