@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0336: (2015-11-30 )
MTLQRVVVTGYGVTSPIGNTPEEFWNSLKEGNVGIGPITKFDSSDFMVKNAAEIHDFPFDKYFVKKDLNRFDMYSLYALYASSEAIQHANLNLDEIDADRFGVIVASGIGGIQEIEEQVIRLHEKGPKRVKPMTLPKALPNMAAGNVAMRLGAHGVCKSINTACASSNDAIGDAFRNIKFGIQDIMVVGGAEAAITKFAIAGFQSLTALSTTEDPSRASIPFDKDRNGFIMGEGSGMLVLESLEHAEKRGATILAEVVGYGNTCDAYHMTSPHPEGLGATKAIQLALVEANIKPEEVNYVNAHGTSTPANEKGESQAIVAALGTDVPVSSTKSFTGHLLGAAGAVEAIATIEAIRHSYVPMTAGTTELSEDITANVIFGQGQDADIRYAISNTFGFGGHNAVLAFKRWED
Atome Classification :
(20 SA)
.........10........20........30........40........50-------........60........70........80........90.....-...100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.--..-.....220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.---.---.---....330.......340.......350.......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
L
Q
R
V
V
V
TGYGVTSPIGN
T
P
E
E
F
W
N
S
L
KEGNVGIGPITKFDSSD
F
M
VKN
A
-------
A
E
IHDFP
F
D
K
Y
F
V
K
K
D
L
N
R
F
D
M
Y
S
L
Y
A
L
YASSE
A
I
Q
HANLNLDEI-DADR
F
G
V
I
V
ASGIG
G
I
Q
E
I
E
E
Q
V
I
R
L
H
EKGPKRVKPMT
L
P
K
A
L
P
N
MAA
G
N
V
A
M
R
LGA
H
G
V
C
K
S
I
N
T
ACASSN
D
A
I
G
D
A
F
R
N
I
K
F
G
I
Q
D
I
M
V
VGG
A
E
A
A
I
T
K
F
A
I
A
G
F
Q
S
L
T
A
LS-TT--ED-PSRASIPFDKDRN
G
F
I
MGEGS
G
M
L
V
L
E
S
L
E
H
A
E
KR
G
A
T
I
L
A
E
V
VGYGNTCDAYHMTSPHPEGLGA
T
K
A
I
Q
L
A
L
V
EANIKPE
E
V
N
Y
V
NAHGTSTPANEKGES
Q
A
I
V
A
ALG---T---D---VPVSST
K
S
F
T
G
H
LLGAA
G
A
V
E
A
I
A
T
I
E
A
I
R
H
SYVPMTAGT
T
E
LSEDIT
A
N
V
I
FGQGQDA
D
I
R
Y
A
I
SNTFGFGGH
N
A
V
L
A
F
KRWED
107
HHSearch
99.32
83%
-78
- C2 -
1OX0
2
?
A:
[20-428]
M
K
L
N
R
V
V
V
T
G
Y
G
V
T
S
P
I
G
N
T
P
E
E
F
W
N
S
L
A
T
G
K
I
G
I
G
G
I
T
K
F
D
H
S
D
F
D
V
H
N
A
-------
A
E
I
Q
D
F
P
F
D
K
Y
F
V
K
K
D
T
N
R
F
D
N
Y
S
L
Y
A
L
Y
A
A
Q
E
A
V
N
H
A
N
L
D
V
E
A
L
-
N
R
D
R
F
G
V
I
V
A
S
G
I
G
G
I
K
E
I
E
D
Q
V
L
R
L
H
E
K
G
P
K
R
V
K
P
M
T
L
P
K
A
L
P
N
M
A
S
G
N
V
A
M
R
F
G
A
N
G
V
C
K
S
I
N
T
A
C
S
S
S
N
D
A
I
G
D
A
F
R
S
I
K
F
G
F
Q
D
V
M
L
V
G
G
T
E
A
S
I
T
P
F
A
I
A
G
F
Q
A
L
T
A
L
S
-
T
T
--
E
D
-
P
T
R
A
S
I
P
F
D
K
D
R
N
G
F
V
M
G
E
G
S
G
M
L
V
L
E
S
L
E
H
A
E
K
R
G
A
T
I
L
A
E
V
V
G
Y
G
N
T
C
D
A
Y
H
M
T
S
P
H
P
E
G
Q
G
A
I
K
A
I
K
L
A
L
E
E
A
E
I
S
P
E
Q
V
A
Y
V
N
A
H
G
T
S
T
P
A
N
E
K
G
E
S
G
A
I
V
A
V
L
G
---
K
---
E
---
V
P
V
S
S
T
K
S
F
T
G
H
L
L
G
A
A
G
A
V
E
A
I
V
T
I
E
A
M
R
H
N
F
V
P
M
T
A
G
T
S
E
V
S
D
Y
I
E
A
N
V
V
Y
G
Q
G
L
E
K
E
I
P
Y
A
I
S
N
T
F
G
F
G
G
H
N
A
V
L
A
F
K
R
W
E
-
1
PsiBlast_PDB
99.15
82%
-78
- C2 -
1OX0
2
?
A:
[20-428]
M
K
L
N
R
V
V
V
T
G
Y
G
V
T
S
P
I
G
N
T
P
E
E
F
W
N
S
L
A
T
G
K
I
G
I
G
G
I
T
K
F
D
H
S
D
F
D
V
H
N
A
-------
A
E
I
Q
D
F
P
F
D
K
Y
F
V
K
K
D
T
N
R
F
D
N
Y
S
L
Y
A
L
Y
A
A
Q
E
A
V
N
H
A
N
L
D
V
E
A
L
-
N
R
D
R
F
G
V
I
V
A
S
G
I
G
G
I
K
E
I
E
D
Q
V
L
R
L
H
E
K
G
P
K
R
V
K
P
M
T
L
P
K
A
L
P
N
M
A
S
G
N
V
A
M
R
F
G
A
N
G
V
C
K
S
I
N
T
A
C
S
S
S
N
D
A
I
G
D
A
F
R
S
I
K
F
G
F
Q
D
V
M
L
V
G
G
T
E
A
S
I
T
P
F
A
I
A
G
F
Q
A
L
T
A
L
S
-
T
T
--
E
D
-
P
T
R
A
S
I
P
F
D
K
D
R
N
G
F
V
M
G
E
G
S
G
M
L
V
L
E
S
L
E
H
A
E
K
R
G
A
T
I
L
A
E
V
V
G
Y
G
N
T
C
D
A
Y
H
M
T
S
P
H
P
E
G
Q
G
A
I
K
A
I
K
L
A
L
E
E
A
E
I
S
P
E
Q
V
A
Y
V
N
A
H
G
T
S
T
P
A
N
E
K
G
E
S
G
A
I
V
A
V
L
G
---
K
---
E
---
V
P
V
S
S
T
K
S
F
T
G
H
L
L
G
A
A
G
A
V
E
A
I
V
T
I
E
A
M
R
H
N
F
V
P
M
T
A
G
T
S
E
V
S
D
Y
I
E
A
N
V
V
Y
G
Q
G
L
E
K
E
I
P
Y
A
I
S
N
T
F
G
F
G
G
H
N
A
V
L
A
F
K
R
W
E
-
22
PsiBlast_CBE
98.91
82%
-77
- C2 -
1OXH
1
?
C:
[21-428]
-
K
L
N
R
V
V
V
T
G
Y
G
V
T
S
P
I
G
N
T
P
E
E
F
W
N
S
L
A
T
G
K
I
G
I
G
G
I
T
K
F
D
H
S
D
F
D
V
H
N
A
-------
A
E
I
Q
D
F
P
F
D
K
Y
F
V
K
K
D
T
N
R
F
D
N
Y
S
L
Y
A
L
Y
A
A
Q
E
A
V
N
H
A
N
L
D
V
E
A
L
-
N
R
D
R
F
G
V
I
V
A
S
G
I
G
G
I
K
E
I
E
D
Q
V
L
R
L
H
E
K
G
P
K
R
V
K
P
M
T
L
P
K
A
L
P
N
M
A
S
G
N
V
A
M
R
F
G
A
N
G
V
C
K
S
I
N
T
A
C
S
S
S
N
D
A
I
G
D
A
F
R
S
I
K
F
G
F
Q
D
V
M
L
V
G
G
T
E
A
S
I
T
P
F
A
I
A
G
F
Q
A
L
T
A
L
S
-
T
T
--
E
D
-
P
T
R
A
S
I
P
F
D
K
D
R
N
G
F
V
M
G
E
G
S
G
M
L
V
L
E
S
L
E
H
A
E
K
R
G
A
T
I
L
A
E
V
V
G
Y
G
N
T
C
D
A
Y
H
M
T
S
P
H
P
E
G
Q
G
A
I
K
A
I
K
L
A
L
E
E
A
E
I
S
P
E
Q
V
A
Y
V
N
A
H
G
T
S
T
P
A
N
E
K
G
E
S
G
A
I
V
A
V
L
G
---
K
---
E
---
V
P
V
S
S
T
K
S
F
T
G
H
L
L
G
A
A
G
A
V
E
A
I
V
T
I
E
A
M
R
H
N
F
V
P
M
T
A
G
T
S
E
V
S
D
Y
I
E
A
N
V
V
Y
G
Q
G
L
E
K
E
I
P
Y
A
I
S
N
T
F
G
F
G
G
H
N
A
V
L
A
F
K
R
W
E
-
4
PsiBlast_PDB
98.77
82%
-76
- C2 -
2RJT
-
?
A:
[2-408]
-
K
L
N
R
V
V
V
T
G
Y
G
V
T
S
P
I
G
N
T
P
A
E
F
W
N
S
L
A
T
G
K
I
G
I
G
G
I
T
K
F
D
H
S
D
F
D
V
H
N
A
-------
A
E
I
Q
D
F
P
F
D
K
Y
F
V
K
K
D
T
N
R
F
D
N
Y
S
L
Y
A
L
Y
A
A
Q
E
A
V
N
H
A
N
L
D
V
A
A
L
-
N
R
D
R
F
G
V
I
V
A
S
G
I
G
G
I
K
E
I
E
D
Q
V
L
R
L
H
E
K
G
P
K
R
V
K
P
M
T
L
P
K
A
L
P
N
M
A
S
G
N
V
A
M
R
F
G
A
N
G
V
C
K
S
I
N
T
A
C
S
S
S
N
D
A
I
G
D
A
F
R
S
I
K
F
G
F
Q
D
V
M
L
V
G
G
T
E
A
S
I
T
P
F
A
I
A
G
F
Q
A
L
T
A
L
S
-
T
T
--
E
D
-
P
T
R
A
S
I
P
F
D
K
D
R
N
G
F
V
M
G
E
G
S
G
M
L
V
L
E
S
L
E
H
A
E
K
R
G
A
T
I
L
A
E
V
V
G
Y
G
N
T
C
D
A
Y
H
M
T
S
P
H
P
E
G
Q
G
A
I
K
A
I
K
L
A
L
E
E
A
E
I
S
P
E
Q
V
A
Y
V
N
A
H
G
T
S
T
P
A
N
E
K
G
E
S
G
A
I
V
A
V
L
G
---
K
---
A
---
V
P
V
S
S
T
K
S
F
T
G
H
L
L
G
A
A
G
A
V
E
A
I
V
T
I
E
A
M
R
H
N
F
V
P
M
T
A
G
T
S
E
V
S
D
Y
I
E
A
N
V
V
Y
G
Q
G
L
A
K
E
I
P
Y
A
I
S
N
T
F
G
F
G
G
H
N
A
V
L
A
F
K
R
W
A
-
3
PsiBlast_PDB
98.57
82%
-77
- C2 -
2ALM
2
?
A:
[21-429]
M
K
L
N
R
V
V
V
T
G
Y
G
V
T
S
P
I
G
N
T
P
E
E
F
W
N
S
L
A
T
G
K
I
G
I
G
G
I
T
K
F
D
H
S
D
F
D
V
H
N
A
-------
A
E
I
Q
D
F
P
F
D
K
Y
F
V
K
K
D
T
N
R
F
D
N
Y
S
L
Y
A
L
Y
A
A
Q
E
A
V
N
H
A
N
L
D
V
E
A
L
-
N
R
D
R
F
G
V
I
V
A
S
G
I
G
G
I
K
E
I
E
D
Q
V
L
R
L
H
E
K
G
P
K
R
V
K
P
M
T
L
P
K
A
L
P
N
M
A
S
G
N
V
A
M
R
F
G
A
N
G
V
C
K
S
I
N
T
A
C
S
S
S
N
D
A
I
G
D
A
F
R
S
I
K
F
G
F
Q
D
V
M
L
V
G
G
T
E
A
S
I
T
P
F
A
I
A
G
F
Q
A
L
T
A
L
S
-
T
T
--
E
D
-
P
T
R
A
S
I
P
F
D
K
D
R
N
G
F
V
M
G
E
G
S
G
M
L
V
L
E
S
L
E
H
A
E
K
R
G
A
T
I
L
A
E
V
V
G
Y
G
N
T
C
D
A
Y
H
M
T
S
P
H
P
E
G
Q
G
A
I
K
A
I
K
L
A
L
E
E
A
E
I
S
P
E
Q
V
A
Y
V
N
A
A
G
T
S
T
P
A
N
E
K
G
E
S
G
A
I
V
A
V
L
G
---
K
---
E
---
V
P
V
S
S
T
K
S
F
T
G
H
L
L
G
A
A
G
A
V
E
A
I
V
T
I
E
A
M
R
H
N
F
V
P
M
T
A
G
T
S
E
V
S
D
Y
I
E
A
N
V
V
Y
A
Q
G
L
E
K
E
I
P
Y
A
I
S
N
T
F
G
F
G
G
H
N
A
V
L
A
F
K
R
W
E
-
21
PsiBlast_CBE
98.51
82%
-77
- C2 -
1OXH
1
?
D:
[21-428]
-
K
L
N
R
V
V
V
T
G
Y
G
V
T
S
P
I
G
N
T
P
E
E
F
W
N
S
L
A
T
G
K
I
G
I
G
G
I
T
K
F
D
H
S
D
F
D
V
H
N
A
-------
A
E
I
Q
D
F
P
F
D
K
Y
F
V
K
K
D
T
N
R
F
D
N
Y
S
L
Y
A
L
Y
A
A
Q
E
A
V
N
H
A
N
L
D
V
E
A
L
-
N
R
D
R
F
G
V
I
V
A
S
G
I
G
G
I
K
E
I
E
D
Q
V
L
R
L
H
E
K
G
P
K
R
V
K
P
M
T
L
P
K
A
L
P
N
M
A
S
G
N
V
A
M
R
F
G
A
N
G
V
C
K
S
I
N
T
A
C
S
S
S
N
D
A
I
G
D
A
F
R
S
I
K
F
G
F
Q
D
V
M
L
V
G
G
T
E
A
S
I
T
P
F
A
I
A
G
F
Q
A
L
T
A
L
S
-
T
T
--
E
D
-
P
T
R
A
S
I
P
F
D
K
D
R
N
G
F
V
M
G
E
G
S
G
M
L
V
L
E
S
L
E
H
A
E
K
R
G
A
T
I
L
A
E
V
V
G
Y
G
N
T
C
D
A
Y
H
M
T
S
P
H
P
E
G
Q
G
A
I
K
A
I
K
L
A
L
E
E
A
E
I
S
P
E
Q
V
A
Y
V
N
A
H
G
T
S
T
P
A
N
E
K
G
E
S
G
A
I
V
A
V
L
G
---
K
---
E
---
V
P
V
S
S
T
K
S
F
T
G
H
L
L
G
A
A
G
A
V
E
A
I
V
T
I
E
A
M
R
H
N
F
V
P
M
T
A
G
T
S
E
V
S
D
Y
I
E
A
N
V
V
Y
G
Q
G
L
E
K
E
I
P
Y
A
I
S
N
T
F
G
F
G
G
H
N
A
V
L
A
F
K
R
W
E
-
23
PsiBlast_CBE
98.38
82%
-78
- C2 -
1OXH
1
?
B:
[21-428]
-
K
L
N
R
V
V
V
T
G
Y
G
V
T
S
P
I
G
N
T
P
E
E
F
W
N
S
L
A
T
G
K
I
G
I
G
G
I
T
K
F
D
H
S
D
F
D
V
H
N
A
-------
A
E
I
Q
D
F
P
F
D
K
Y
F
V
K
K
D
T
N
R
F
D
N
Y
S
L
Y
A
L
Y
A
A
Q
E
A
V
N
H
A
N
L
D
V
E
A
L
-
N
R
D
R
F
G
V
I
V
A
S
G
I
G
G
I
K
E
I
E
D
Q
V
L
R
L
H
E
K
G
P
K
R
V
K
P
M
T
L
P
K
A
L
P
N
M
A
S
G
N
V
A
M
R
F
G
A
N
G
V
C
K
S
I
N
T
A
C
S
S
S
N
D
A
I
G
D
A
F
R
S
I
K
F
G
F
Q
D
V
M
L
V
G
G
T
E
A
S
I
T
P
F
A
I
A
G
F
Q
A
L
T
A
L
S
-
T
T
--
E
D
-
P
T
R
A
S
I
P
F
D
K
D
R
N
G
F
V
M
G
E
G
S
G
M
L
V
L
E
S
L
E
H
A
E
K
R
G
A
T
I
L
A
E
V
V
G
Y
G
N
T
C
D
A
Y
H
M
T
S
P
H
P
E
G
Q
G
A
I
K
A
I
K
L
A
L
E
E
A
E
I
S
P
E
Q
V
A
Y
V
N
A
H
G
T
S
T
P
A
N
E
K
G
E
S
G
A
I
V
A
V
L
G
---
K
---
E
---
V
P
V
S
S
T
K
S
F
T
G
H
L
L
G
A
A
G
A
V
E
A
I
V
T
I
E
A
M
R
H
N
F
V
P
M
T
A
G
T
S
E
V
S
D
Y
I
E
A
N
V
V
Y
G
Q
G
L
E
K
E
I
P
Y
A
I
S
N
T
F
G
F
G
G
H
N
A
V
L
A
F
K
R
W
E
-
2
PsiBlast_PDB
98.33
82%
-78
- C2 -
1OXH
1
?
A:
[21-428]
-
K
L
N
R
V
V
V
T
G
Y
G
V
T
S
P
I
G
N
T
P
E
E
F
W
N
S
L
A
T
G
K
I
G
I
G
G
I
T
K
F
D
H
S
D
F
D
V
H
N
A
-------
A
E
I
Q
D
F
P
F
D
K
Y
F
V
K
K
D
T
N
R
F
D
N
Y
S
L
Y
A
L
Y
A
A
Q
E
A
V
N
H
A
N
L
D
V
E
A
L
-
N
R
D
R
F
G
V
I
V
A
S
G
I
G
G
I
K
E
I
E
D
Q
V
L
R
L
H
E
K
G
P
K
R
V
K
P
M
T
L
P
K
A
L
P
N
M
A
S
G
N
V
A
M
R
F
G
A
N
G
V
C
K
S
I
N
T
A
C
S
S
S
N
D
A
I
G
D
A
F
R
S
I
K
F
G
F
Q
D
V
M
L
V
G
G
T
E
A
S
I
T
P
F
A
I
A
G
F
Q
A
L
T
A
L
S
-
T
T
--
E
D
-
P
T
R
A
S
I
P
F
D
K
D
R
N
G
F
V
M
G
E
G
S
G
M
L
V
L
E
S
L
E
H
A
E
K
R
G
A
T
I
L
A
E
V
V
G
Y
G
N
T
C
D
A
Y
H
M
T
S
P
H
P
E
G
Q
G
A
I
K
A
I
K
L
A
L
E
E
A
E
I
S
P
E
Q
V
A
Y
V
N
A
H
G
T
S
T
P
A
N
E
K
G
E
S
G
A
I
V
A
V
L
G
---
K
---
E
---
V
P
V
S
S
T
K
S
F
T
G
H
L
L
G
A
A
G
A
V
E
A
I
V
T
I
E
A
M
R
H
N
F
V
P
M
T
A
G
T
S
E
V
S
D
Y
I
E
A
N
V
V
Y
G
Q
G
L
E
K
E
I
P
Y
A
I
S
N
T
F
G
F
G
G
H
N
A
V
L
A
F
K
R
W
E
-
5
PsiBlast_PDB
88.57
49%
-70
- C2 -
1E5M
-
FABF_SYNY3
A:
[7-416]
---
K
R
V
V
V
T
G
L
G
A
I
T
P
I
G
N
T
L
Q
D
Y
W
Q
G
L
M
E
G
R
N
G
I
G
P
I
T
R
F
D
A
S
D
Q
A
C
R
F
G
-------
G
E
V
K
D
F
D
A
T
Q
F
L
D
R
K
E
A
K
R
M
D
R
F
C
H
F
A
V
C
A
S
Q
Q
A
I
N
D
A
K
L
V
I
N
E
L
-
N
A
D
E
I
G
V
L
I
G
T
G
I
G
G
L
K
V
L
E
D
Q
Q
T
I
L
L
D
K
G
P
S
R
C
S
P
F
M
I
P
M
M
I
A
N
M
A
S
G
L
T
A
I
N
L
G
A
K
G
P
N
N
C
T
V
T
A
C
A
A
G
S
N
A
I
G
D
A
F
R
L
V
Q
N
G
Y
A
K
A
M
I
C
G
G
T
E
A
A
I
T
P
L
S
Y
A
G
F
A
S
A
R
A
L
S
F
R
N
--
D
D
-
P
L
H
A
S
R
P
F
D
K
D
R
D
G
F
V
M
G
E
G
S
G
I
L
I
L
E
E
L
E
S
A
L
A
R
G
A
K
I
Y
G
E
M
V
G
Y
A
M
T
C
D
A
Y
H
I
T
A
P
V
P
D
G
R
G
A
T
R
A
I
A
W
A
L
K
D
S
G
L
K
P
E
M
V
S
Y
I
N
A
H
G
T
S
T
P
A
N
D
V
T
E
T
R
A
I
K
Q
A
L
G
---
N
HAY
N
---
I
A
V
S
S
T
K
S
M
T
G
H
L
L
G
G
S
G
G
I
E
A
V
A
T
V
M
A
I
A
E
D
K
V
P
P
T
I
N
L
E
N
P
D
P
E
C
D
L
D
Y
V
P
G
Q
S
R
A
L
I
V
D
V
A
L
S
N
S
F
G
F
G
G
H
N
V
T
L
A
F
K
K
Y
Q
-
104
HHSearch
88.48
49%
-70
- C2 -
1E5M
-
FABF_SYNY3
A:
[6-415]
--
K
K
R
V
V
V
T
G
L
G
A
I
T
P
I
G
N
T
L
Q
D
Y
W
Q
G
L
M
E
G
R
N
G
I
G
P
I
T
R
F
D
A
S
D
Q
A
C
R
F
G
-------
G
E
V
K
D
F
D
A
T
Q
F
L
D
R
K
E
A
K
R
M
D
R
F
C
H
F
A
V
C
A
S
Q
Q
A
I
N
D
A
K
L
V
I
N
E
L
-
N
A
D
E
I
G
V
L
I
G
T
G
I
G
G
L
K
V
L
E
D
Q
Q
T
I
L
L
D
K
G
P
S
R
C
S
P
F
M
I
P
M
M
I
A
N
M
A
S
G
L
T
A
I
N
L
G
A
K
G
P
N
N
C
T
V
T
A
C
A
A
G
S
N
A
I
G
D
A
F
R
L
V
Q
N
G
Y
A
K
A
M
I
C
G
G
T
E
A
A
I
T
P
L
S
Y
A
G
F
A
S
A
R
A
L
S
-
F
R
N-
D
D
-
P
L
H
A
S
R
P
F
D
K
D
R
D
G
F
V
M
G
E
G
S
G
I
L
I
L
E
E
L
E
S
A
L
A
R
G
A
K
I
Y
G
E
M
V
G
Y
A
M
T
C
D
A
Y
H
I
T
A
P
V
P
D
G
R
G
A
T
R
A
I
A
W
A
L
K
D
S
G
L
K
P
E
M
V
S
Y
I
N
A
H
G
T
S
T
P
A
N
D
V
T
E
T
R
A
I
K
Q
A
L
G
---
N
HAY
N
---
I
A
V
S
S
T
K
S
M
T
G
H
L
L
G
G
S
G
G
I
E
A
V
A
T
V
M
A
I
A
E
D
K
V
P
P
T
I
N
L
E
N
P
D
P
E
C
D
L
D
Y
V
P
G
Q
S
R
A
L
I
V
D
V
A
L
S
N
S
F
G
F
G
G
H
N
V
T
L
A
F
K
K
Y
Q
-
24
PsiBlast_CBE
87.86
47%
-67
- C2 -
4LS8
5
FABF_BACSU
B:
[14-425]
M
T
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
D
F
N
V
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
N
I
T
D
E
-
I
A
P
R
V
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
N
--
P
D
-
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
---
E
HAH
K
---
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
L
D
Y
V
P
D
E
A
R
R
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
S
26
PsiBlast_CBE
87.74
47%
-67
- C2 -
4LS5
4
FABF_BACSU
B:
[14-425]
M
T
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
D
F
N
V
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
N
I
T
D
E
-
I
A
P
R
V
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
N
--
P
D
-
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
---
E
HAH
K
---
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
L
D
Y
V
P
D
E
A
R
R
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
-
8
PsiBlast_PDB
87.24
47%
-65
- C2 -
4LS8
9
FABF_BACSU
A:
[14-425]
M
T
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
D
F
N
V
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
N
I
T
D
E
-
I
A
P
R
V
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
N
--
P
D
-
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
---
E
HAH
K
---
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
L
D
Y
V
P
D
E
A
R
R
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
S
109
HHSearch
87.09
42%
-67
- C2 -
3KZU
2
?
A:
[9-427]
--
M
R
R
V
V
I
T
G
L
G
L
V
S
P
L
A
S
G
V
E
E
T
W
K
R
L
L
A
G
E
S
G
A
R
R
V
T
E
F
E
V
D
D
L
A
C
Q
I
A
CRIPVGD
G
T
N
G
T
F
N
P
D
L
H
M
D
P
K
E
Q
R
K
V
D
P
F
I
V
Y
A
V
G
A
A
D
Q
A
L
D
D
A
G
W
H
P
E
N
D
E
D
Q
V
R
T
G
V
L
I
G
S
G
I
G
G
I
E
G
I
V
E
A
G
Y
T
L
R
D
K
G
P
R
R
I
S
P
F
F
I
P
G
R
L
I
N
L
A
S
G
H
V
S
I
K
H
K
L
R
G
P
N
H
S
V
V
T
A
C
A
T
G
T
H
A
I
G
D
A
A
R
L
I
A
F
G
D
A
D
V
M
V
A
G
G
T
E
S
P
V
S
R
I
S
L
A
G
F
A
A
C
K
A
L
S
-
T
E
RN
D
D
-
P
T
A
A
S
R
P
Y
D
E
D
R
D
G
F
V
M
G
E
G
A
G
I
V
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
A
E
V
I
G
Y
G
M
S
G
D
A
F
H
I
T
A
P
T
E
S
G
E
G
A
Q
R
C
M
V
A
A
L
K
R
A
G
I
V
P
D
E
I
D
Y
I
N
A
H
G
T
S
T
M
-
A
D
T
I
E
L
G
A
V
E
R
V
V
G
---
E
AAA
K
---
I
S
M
S
S
T
K
S
S
I
G
H
L
L
G
A
A
G
A
A
E
A
V
F
S
T
L
A
I
R
D
N
I
A
P
A
T
L
N
L
D
N
P
A
A
Q
T
R
I
D
L
V
P
H
K
P
R
E
R
K
I
D
V
A
L
S
N
S
F
G
F
G
G
T
N
A
S
L
V
L
R
R
Y
T
A
6
PsiBlast_PDB
87.05
47%
-68
- C2 -
4LS5
5
FABF_BACSU
A:
[14-425]
M
T
K
K
R
V
V
V
T
G
L
G
A
L
S
P
L
G
N
D
V
D
T
S
W
N
N
A
I
N
G
V
S
G
I
G
P
I
T
R
V
D
A
E
E
Y
P
A
K
V
A
-------
A
E
L
K
D
F
N
V
E
D
Y
M
D
K
K
E
A
R
K
M
D
R
F
T
Q
Y
A
V
V
A
A
K
M
A
V
E
D
A
D
L
N
I
T
D
E
-
I
A
P
R
V
G
V
W
V
G
S
G
I
G
G
L
E
T
L
E
S
Q
F
E
I
F
L
T
K
G
P
R
R
V
S
P
F
F
V
P
M
M
I
P
D
M
A
T
G
Q
I
S
I
A
L
G
A
K
G
V
N
S
C
T
V
T
A
C
A
T
G
T
N
S
I
G
D
A
F
K
V
I
Q
R
G
D
A
D
V
M
V
T
G
G
T
E
A
P
L
T
R
M
S
F
A
G
F
S
A
N
K
A
L
S
-
T
N
--
P
D
-
P
K
T
A
S
R
P
F
D
K
N
R
D
G
F
V
M
G
E
G
A
G
I
I
V
L
E
E
L
E
H
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
S
T
G
D
A
Y
H
I
T
A
P
A
Q
D
G
E
G
G
A
R
A
M
Q
E
A
I
K
D
A
G
I
A
P
E
E
I
D
Y
I
N
A
H
G
T
S
T
Y
Y
N
D
K
Y
E
T
M
A
I
K
T
V
F
G
---
E
HAH
K
---
L
A
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
G
I
E
A
I
F
S
I
L
A
I
K
E
G
V
I
P
P
T
I
N
I
Q
T
P
D
E
E
C
D
L
D
Y
V
P
D
E
A
R
R
Q
E
L
N
Y
V
L
S
N
S
L
G
F
G
G
H
N
A
T
L
I
F
K
K
Y
Q
S
33
PsiBlast_CBE
87.01
41%
-68
- C2 -
4B7V
1
?
B:
[26-435]
---
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
A
P
I
E
H
M
D
L
S
A
Y
S
T
R
F
G
-------
G
S
V
K
G
F
N
V
E
E
Y
L
S
A
K
E
A
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
G
L
E
V
T
D
A
-
N
R
E
R
I
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
C
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
-
T
R
--
N
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
---
E
---
H
AHA
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
E
G
C
D
L
D
L
V
A
H
E
A
K
P
R
K
I
D
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
A
-
17
PsiBlast_PDB
86.97
41%
-68
- C2 -
4JPF
3
?
A:
[25-435]
--
R
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
A
P
I
E
H
M
D
L
S
A
Y
S
T
R
F
G
-------
G
S
V
K
G
F
N
V
E
E
Y
L
S
A
K
E
A
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
G
L
E
V
T
D
A
-
N
R
E
R
I
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
C
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
-
T
R
--
N
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
---
E
---
H
AHA
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
E
G
C
D
L
D
L
V
A
H
E
A
K
P
R
K
I
D
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
A
-
34
PsiBlast_CBE
86.93
40%
-66
- C2 -
4JB6
1
?
B:
[2-413]
-
S
R
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
A
P
I
E
H
M
D
L
S
A
Y
S
T
R
F
G
-------
G
S
V
K
G
F
N
V
E
E
Y
L
S
A
K
E
A
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
G
L
E
V
T
D
A
-
N
R
E
R
I
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
Q
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
-
T
R
--
N
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
---
E
---
H
AHA
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
E
G
C
D
L
D
L
V
A
H
E
A
K
P
R
K
I
D
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
A
-
11
PsiBlast_PDB
86.91
46%
-67
- C2 -
2GQD
-
FABF_STAAC (first)
A:
[5-413]
---
K
R
V
V
I
T
G
M
G
A
L
S
P
I
G
N
D
V
K
T
T
W
E
N
A
L
K
G
V
N
G
I
D
K
I
T
R
I
D
T
E
P
Y
S
V
H
L
A
-------
G
E
L
K
N
F
N
I
E
D
H
I
D
K
K
E
A
R
R
M
D
R
F
T
Q
Y
A
I
V
A
A
R
E
A
V
K
D
A
Q
L
D
I
N
E
N
-
T
A
D
R
I
G
V
W
I
G
S
G
I
G
G
M
E
T
F
E
I
A
H
K
Q
L
M
D
K
G
P
R
R
V
S
P
F
F
V
P
M
L
I
P
D
M
A
T
G
Q
V
S
I
D
L
G
A
K
G
P
N
G
A
T
V
T
A
C
A
T
G
T
N
S
I
G
E
A
F
K
I
V
Q
R
G
D
A
D
A
M
I
T
G
G
T
E
A
P
I
T
H
M
A
I
A
G
F
S
A
S
R
A
L
S
-
T
N
--
D
D
-
I
E
T
A
C
R
P
F
Q
E
G
R
D
G
F
V
M
G
E
G
A
G
I
L
V
I
E
S
L
E
S
A
Q
A
R
G
A
N
I
Y
A
E
I
V
G
Y
G
T
T
G
D
A
Y
H
I
T
A
P
A
P
E
G
E
G
G
S
R
A
M
Q
A
A
M
D
D
A
G
I
E
P
K
D
V
Q
Y
L
N
A
H
G
T
S
T
P
V
G
D
L
N
E
V
K
A
I
K
N
T
F
G
EAA
K
---
H
---
L
K
V
S
S
T
K
S
M
T
G
H
L
L
G
A
T
G
G
I
E
A
I
F
S
A
L
S
I
K
D
S
K
V
A
P
T
I
H
A
V
T
P
D
P
E
C
D
L
D
I
V
P
N
E
A
Q
D
L
D
I
T
Y
A
M
S
N
S
L
G
F
G
G
H
N
A
V
L
V
F
K
K
F
E
A
16
PsiBlast_PDB
86.90
41%
-67
- C2 -
4B7V
1
?
A:
[24-435]
-
S
R
R
R
V
V
I
T
G
M
G
M
L
S
P
L
G
L
D
V
P
S
S
W
E
G
I
L
A
G
R
S
G
I
A
P
I
E
H
M
D
L
S
A
Y
S
T
R
F
G
-------
G
S
V
K
G
F
N
V
E
E
Y
L
S
A
K
E
A
R
K
L
D
L
F
I
Q
Y
G
L
A
A
S
F
Q
A
V
R
D
S
G
L
E
V
T
D
A
-
N
R
E
R
I
G
V
S
M
G
S
G
I
G
G
L
T
N
I
E
N
N
C
R
S
L
F
E
Q
G
P
R
R
I
S
P
F
F
V
P
G
S
I
I
N
M
V
S
G
F
L
S
I
H
L
G
L
Q
G
P
N
Y
A
L
T
T
A
C
T
T
G
T
H
S
I
G
M
A
A
R
N
I
A
Y
G
E
A
D
V
M
V
A
G
G
S
E
M
A
A
C
G
L
G
L
G
G
F
G
A
A
R
A
L
S
-
T
R
--
N
D
E
P
T
R
A
S
R
P
W
D
R
D
R
D
G
F
V
L
S
D
G
S
G
A
L
V
L
E
E
L
E
H
A
R
A
R
G
A
R
I
Y
A
E
L
V
G
F
G
M
S
G
D
A
F
H
M
T
A
P
P
E
D
G
A
G
A
A
R
C
M
K
N
A
L
R
D
A
G
L
D
P
R
Q
V
D
Y
I
N
A
H
G
T
S
T
P
A
G
D
I
A
E
I
A
A
V
K
S
V
F
G
---
E
---
H
AHA
L
S
M
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
V
L
A
L
R
D
Q
V
A
P
P
T
I
N
L
D
N
P
D
E
G
C
D
L
D
L
V
A
H
E
A
K
P
R
K
I
D
V
A
L
S
N
S
F
G
F
G
G
T
N
G
T
L
V
F
R
R
F
A
-