@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0343: (2015-11-30 )
MLDLKRIRTDFDVVAKKLATRGVDQETLTTLKELDIKRRELLIKAEEAKAQRNVASAAIAQAKRNKENADEQIAAMQTLSADIKAIDAELADVDANLQSMVTVLPNTPADDVPLGADEDENVEVRRWGTPREFDFETKAHWDLGESLGILDWERGAKVTGSRFLFYKGLGARLERAIYSFMLDEHAKEGYTEVIPPYMVNHDSMFGTGQYPKFKEDTFELADSPFVLIPTAEVPLTNYYRDEIIDGKELPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYQELEKMTANAENILQKLNLPYRVITLCTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNTEDFQARRAQIRYRDEVDGKVRLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEVLRPYMGNIDIIKPN
Atome Classification :
(24 SA)
-----------------------------------------------------------------------------------------------........--.10-.........20...--...--..-30.---.......40....--------....50........60----------------........-----------------------------.70-----........------.80........90........100.......110......-.120.......-.130--------------------.--------------------......140.......150.-...-...-160.......170.......180.......190.......200.......210.......220.---.--.......230.......240.......250.......260.......270.......280..--.....290-.--.......300.......310.......320.......330.......340.......350.......360.......370-.-----..-----....380.......390.......400.......410.......420...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------ML
D
L
K
R
I
R
--
T
D
--
F
D
V
V
A
K
K
L
A
TRGV
D
--
Q
E
T
--
L
T
-
T
L
K
---
E
L
D
I
K
R
R
E
L
L
I
K
A
--------
E
E
A
K
A
QR
N
V
A
S
A
A
I
A
-----------------
Q
A
KRNKEN-----------------------------
A
D
------
E
Q
I
A
A
M
Q
T
------
L
S
A
D
I
K
A
I
D
A
E
L
A
D
VDA
N
L
Q
S
M
V
T
VLPNTPADDVPLGADE-DE-N
V
E
V
R
RWG-TPRE--------------------F--------------------DFETKAHWDLGESLGILDWE-RGA-KVT-GS
R
F
L
F
YK
G
L
G
A
R
L
E
R
A
I
Y
S
F
M
L
D
E
H
A
KEG
Y
T
EVIPP
Y
M
VNHDSMFGTGQYPKFK
E
D
T
F
EL--A---D--S
P
F
V
L
I
PTAEVP
L
T
N
Y
Y
R
D
EIIDGKEL
P
I
Y
F
T
AMSP
S
F
R
SEAGSAGRD
T
R
G
L
I
R
L
H
Q
F
H
K
V
E
--
M
V
KFAK
P
--
E
--
E
S
Y
Q
E
L
E
K
MTA
N
A
E
N
I
L
Q
K
LNL
P
Y
R
V
I
T
L
CTGDMGFSA
A
K
T
Y
D
L
E
V
W
IPA
Q
N
T
Y
R
E
I
S
SCSN
T
E
D
F
Q
A
R
R
A
Q
I
R
Y
RDEVD-G-----
K
V
-----
R
L
L
H
TLNGSGL
A
V
G
R
T
V
A
A
I
L
E
N
YQNEDG
S
V
T
I
P
E
V
L
R
P
YMGNIDIIKPN
1
PsiBlast_PDB
88.77
54%
-70
- C2 -
2DQ3
1
SYS_AQUAE
A:
[2-424]
------------------------------------------------------------------------------------------------
I
D
I
N
L
I
R
--
E
K
--
P
D
Y
V
K
E
R
L
A
T
R
--
D
--
K
E
L
--
V
S
-
L
V
D
K
V
L
E
L
D
K
R
R
R
E
I
I
K
R
L
--------
E
A
L
R
S
E
R
N
K
L
S
K
E
I
G
-----------------
K
L
K
R
E
G
K
D
-----------------------------
T
T
------
E
I
Q
N
R
V
K
E
------
L
K
E
E
I
D
R
L
E
E
E
L
R
K
V
E
E
E
L
K
N
T
L
L
W
I
P
N
L
P
H
P
S
V
P
V
G
E
D
E
-
K
D
-
N
V
E
V
R
R
W
G
-
E
P
R
K
--------------------
F
--------------------
D
F
E
P
K
P
H
W
E
I
G
E
R
L
G
I
L
D
F
K
-
R
G
A
-
K
L
S
-
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
K
K
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
E
D
L
Y
K
C
--
E
---
R
--
D
N
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
K
E
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
--
L
V
K
I
V
H
P
--
D
--
T
S
Y
D
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
F
K
D
S
K
T
-
G
-----
K
N
-----
R
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
G
T
-
D
V
I
R
P
E
43
HHSearch
88.65
55%
-71
- C2 -
2DQ3
1
SYS_AQUAE
A:
[1-424]
-----------------------------------------------------------------------------------------------
M
I
D
I
N
L
I
R
--
E
K
--
P
D
Y
V
K
E
R
L
A
T
R
D
K
E
L-
V
S
L
--
V
D
-
K
V
L
---
E
L
D
K
R
R
R
E
I
I
K
R
L
--------
E
A
L
R
S
E
R
N
K
L
S
K
E
I
G
-----------------
K
L
K
R
E
G
K
D
-----------------------------
T
T
------
E
I
Q
N
R
V
K
E
------
L
K
E
E
I
D
R
L
E
E
E
L
R
K
V
E
E
E
L
K
N
T
L
L
W
I
P
N
L
P
H
P
S
V
P
V
G
E
D
E
-
K
D
-
N
V
E
V
R
R
W
G
-
E
P
R
K
--------------------
F
--------------------
D
F
E
P
K
P
H
W
E
I
G
E
R
L
G
I
L
D
F
K
-
R
G
A
-
K
L
S
-
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
K
K
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
E
D
L
Y
K
C
--
E
---
R
--
D
N
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
K
E
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
--
L
V
K
I
V
H
P
--
D
--
T
S
Y
D
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
F
K
D
S
K
T
-
G
-----
K
N
-----
R
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
G
T
D
V
I
R
P
E
-
45
HHSearch
83.12
41%
-66
- C2 -
2DQ0
5
SYS_PYRHO
A:
[1-446]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
--
E
N
--
P
E
L
V
K
N
D
L
I
K
R
G
E
L
EK
V
K
W
--
V
D
-
E
I
L
---
K
L
D
T
E
W
R
T
K
L
K
E
I
--------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
-----------------
K
R
R
K
K
G
E
P
-----------------------------
V
D
------
E
L
L
A
K
S
R
E
------
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
F
W
G
-
K
A
R
V
WKGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
--------------------
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
-
R
A
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
--
E
---
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
R
T
D
-
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
E
I
V
P
V
E
3
PsiBlast_PDB
82.57
39%
-69
- C2 -
2ZR2
5
SYS_PYRHO
A:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
--
E
N
--
P
E
L
V
K
N
D
L
I
K
R
G
E
L
--
E
K
V
K
W
V
D
-
E
I
L
---
K
L
D
T
E
W
R
T
K
L
K
E
I
--------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
-----------------
K
R
R
K
K
G
E
P
-----------------------------
V
D
------
E
L
L
A
K
S
R
E
------
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
F
W
G
-
K
A
R
V
--------------------
W
KGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
-
R
A
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
--
E
---
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
R
T
D
-
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
E
I
V
P
V
E
2
PsiBlast_PDB
82.19
39%
-68
- C2 -
2DQ0
5
SYS_PYRHO
A:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
--
E
N
--
P
E
L
V
K
N
D
L
I
K
R
G
E
L
--
E
K
V
K
W
V
D
-
E
I
L
---
K
L
D
T
E
W
R
T
K
L
K
E
I
--------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
-----------------
K
R
R
K
K
G
E
P
-----------------------------
V
D
------
E
L
L
A
K
S
R
E
------
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
F
W
G
-
K
A
R
V
--------------------
W
KGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
-
R
A
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
--
E
---
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
R
T
D
-
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
E
I
V
P
V
E
21
PsiBlast_CBE
81.99
39%
-68
- C2 -
2ZR2
4
SYS_PYRHO
B:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
--
E
N
--
P
E
L
V
K
N
D
L
I
K
R
G
E
L
--
E
K
V
KW
V
D
-
E
I
L
---
K
L
D
T
E
W
R
T
K
L
K
E
I
--------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
-----------------
K
R
R
K
K
G
E
P
-----------------------------
V
D
------
E
L
L
A
K
S
R
E
------
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
F
W
G
-
K
A
R
V
--------------------
W
KGHLERFLEQSQGKMEYEIL
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
-
R
A
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
--
E
---
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
R
T
D
-
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
E
I
V
P
V
E
4
PsiBlast_PDB
81.93
39%
-67
- C2 -
2ZR3
-
SYS_PYRHO
A:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
--
E
N
--
P
E
L
V
K
N
D
L
I
K
R
G
E
L
--
E
K
V
K
W
V
D
-
E
I
L
---
K
L
D
T
E
W
R
T
K
L
K
E
I
--------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
-----------------
K
R
R
K
K
G
E
P
-----------------------------
V
D
------
E
L
L
A
K
S
R
E
------
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
F
W
G
-
K
A
R
V
--------------------
W
KGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
-
R
A
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
--
E
---
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
R
T
D
-
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
E
I
V
P
V
E
22
PsiBlast_CBE
81.91
39%
-67
- C2 -
2DQ0
4
SYS_PYRHO
B:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
--
E
N
--
P
E
L
V
K
N
D
L
I
K
R
G
E
L
--
E
K
V
KW
V
D
-
E
I
L
---
K
L
D
T
E
W
R
T
K
L
K
E
I
--------
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
-----------------
K
R
R
K
K
G
E
P
-----------------------------
V
D
------
E
L
L
A
K
S
R
E
------
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
-
N
D
-
N
V
P
I
R
F
W
G
-
K
A
R
V
--------------------
W
KGHLERFLEQSQGKMEYEIL
E
W
K
P
K
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
-
R
A
A
-
K
V
S
-
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
--
E
---
D
--
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
--
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
R
T
D
-
E
-----
K
P
-----
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
E
I
V
P
V
E
23
PsiBlast_CBE
78.49
36%
-60
- C2 -
1SET
1
SYS_THET2
B:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
--
Q
E
--
P
E
V
F
H
R
A
I
R
E
K
G
V
A
--
L
D
L
--
E
A
-
L
L
A
---
L
D
R
-
E
V
Q
E
L
K
K
R
L
--------
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
-----------------
K
A
P
--
P
E
E
-----------------------------
K
E
------
A
L
I
A
R
G
K
A
------
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
-
A
--
N
R
E
I
K
R
V
G
-
G
P
P
E
--------------------
F
--------------------
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
--
A
---
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
QY
V
L
T
E
A
S
L
--
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
P
-
E
-
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
-
E
V
L
E
P
C
34
Fugue
77.99
33%
-61
- C2 -
3LSS
2
?
B:
[3-470]
-------------------------------------------------------------------------------------------G
S
M
M
V
L
D
I
Q
L
F
R
--
D
E
T
G
A
N
I
I
R
E
S
Q
R
R
R
F
A
D
--
P
D
I
--
V
D
-
A
I
I
---
E
A
D
K
K
W
R
R
T
Q
F
L
T
--------
E
A
S
K
K
L
I
N
I
C
S
K
A
V
G
-----------------
A
K
K
K
A
K
E
A
DGDTSEIP
P
Q
V
K
E
A
Y
E
N
GTLK
G
E
Q
V
E
Q
LC
V
L
------
Q
L
K
Q
L
S
K
D
------
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
I
A
Q
D
E
-
E
T
G
N
T
V
V
R
T
F
G
-
N
T
T
K
--------------------
R
----------------------
A
K
L
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
-
K
A
V
-
T
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
E
E
L
Y
Q
V
S
G
D
---
G
--
D
K
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
T
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
--
Q
F
V
V
C
S
P
RQ
E
--
E
S
W
R
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
Y
G
P
N
L
R
-
G
TAAQN
V
K
-----
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
E
M
I
R
F
E
8
PsiBlast_PDB
77.94
36%
-59
- C2 -
1SET
1
SYS_THET2
A:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
--
Q
E
--
P
E
V
F
H
R
A
I
R
E
K
G
V
A
--
L
D
L
--
E
A
-
L
L
A
---
L
D
R
-
E
V
Q
E
L
K
K
R
L
--------
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
-----------------
K
A
P
--
P
E
E
-----------------------------
K
E
------
A
L
I
A
R
G
K
A
------
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
-
A
--
N
R
E
I
K
R
V
G
-
G
P
P
E
--------------------
F
--------------------
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
--
A
---
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
--
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
P
-
E
-
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
-
E
V
L
E
P
C
5
PsiBlast_PDB
77.90
36%
-62
- C2 -
1SRY
-
SYS_THET2
A:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
--
Q
E
--
P
E
V
F
H
R
A
I
R
E
K
G
V
A
--
L
D
L
--
E
A
-
L
L
A
---
L
D
R
-
E
V
Q
E
L
K
K
R
L
--------
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
-----------------
K
A
P
--
P
E
E
-----------------------------
K
E
------
A
L
I
A
R
G
K
A
------
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
-
A
--
N
R
E
I
K
R
V
G
-
G
P
P
E
--------------------
F
--------------------
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
--
A
---
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
--
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
P
-
E
-
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
-
E
V
L
E
P
C
24
PsiBlast_CBE
77.60
36%
-59
- C2 -
1SES
1
SYS_THET2
B:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
--
Q
E
--
P
E
V
F
H
R
A
I
R
E
K
G
V
A
--
L
D
L
--
E
A
-
L
L
A
---
L
D
R
-
E
V
Q
E
L
K
K
R
L
--------
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
-----------------
K
A
P
--
P
E
E
-----------------------------
K
E
------
A
L
I
A
R
G
K
A
------
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
-
A
--
N
R
E
I
K
R
V
G
-
G
P
P
E
--------------------
F
--------------------
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
--
A
---
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
QY
V
L
T
E
A
S
L
--
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
P
-
E
-
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
-
E
V
L
E
P
C
7
PsiBlast_PDB
77.20
36%
-58
- C2 -
1SES
1
SYS_THET2
A:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
--
Q
E
--
P
E
V
F
H
R
A
I
R
E
K
G
V
A
--
L
D
L
--
E
A
-
L
L
A
---
L
D
R
-
E
V
Q
E
L
K
K
R
L
--------
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
-----------------
K
A
P
--
P
E
E
-----------------------------
K
E
------
A
L
I
A
R
G
K
A
------
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
-
A
--
N
R
E
I
K
R
V
G
-
G
P
P
E
--------------------
F
--------------------
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
--
A
---
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
--
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
P
-
E
-
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
-
E
V
L
E
P
C
44
HHSearch
76.68
37%
-57
- C2 -
1SES
1
SYS_THET2
A:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
--
Q
E
--
P
E
V
F
H
R
A
I
R
E
K
G
V
A
---
L
D
--
L
E
-
A
L
L
---
A
L
D
R
E
V
Q
E
L
K
K
R
L
--------
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
-----------------
K
A
P
P
E
E
-------------------------------
K
E
------
A
L
I
A
R
G
K
A
------
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
--
A
-
N
R
E
I
K
R
V
G
-
G
P
P
E
--------------------
F
--------------------
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
-
R
I
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
--
A
---
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
P
E
G
-------
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
V
L
E
P
C
G
26
PsiBlast_CBE
76.44
32%
-61
- C2 -
3LSS
2
?
B:
[7-468]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
D
E
T
G
--
A
N
I
I
R
E
S
Q
R
R
R
F
A
D
--
P
D
I
--
V
D
-
A
I
I
---
E
A
D
K
K
W
R
R
T
Q
F
L
T
--------
E
A
S
K
K
L
I
N
I
C
S
K
A
V
G
A
K
K
K
A
KEADGDTSEIP
P
Q
V
K
E
A
Y
E
N
-----------------------------
G
T
LK
G
E
Q
V
E
Q
L
C
V
L
Q
L
K
Q
L
S
K
D
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
I
A
Q
D
E
-
E
T
G
N
T
V
V
R
T
F
G
N
T
T
K
R
--------------------
A
--------------------
K
L
N
---
H
V
S
I
M
E
R
L
G
M
M
D
T
S
-
K
A
V
T
S
M
A
-
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
E
E
L
Y
Q
V
--
S
GDG
D
--
K
K
Y
-
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
T
E
L
K
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L
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Y
A
G
M
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T
C
F
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A
G
A
H
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L
G
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F
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V
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Q
F
D
K
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--
Q
F
V
V
C
S
P
RQ
E
--
E
S
W
R
H
L
E
D
M
I
T
T
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E
F
N
K
S
L
G
L
P
Y
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V
V
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C
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A
L
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N
A
A
A
K
K
Y
D
L
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A
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A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
Y
G
P
N
L
R
-
G
-----
T
A
AQN
V
K
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
E
M
I
R
F
E
42
HHSearch
76.21
33%
-59
- C2 -
3LSS
4
?
A:
[7-470]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
--
D
E
T
G
A
N
I
I
R
E
S
Q
R
R
R
F
A
D
--
P
D
I
--
V
D
-
A
I
I
---
E
A
D
K
K
W
R
R
T
Q
F
L
T
--------
E
A
S
K
K
L
I
N
I
C
S
K
A
V
G
-----------------
A
K
K
K
A
K
E
A
C----------------------------
V
L
------
Q
L
K
Q
L
S
K
D
------
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
I
A
Q
D
E
E
T
G
-
N
T
V
V
R
T
F
G
-
N
T
T
K
--------------------
R
----------------------
A
K
L
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
-
K
A
V
T
S
M
A
-
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
E
E
L
Y
Q
V
--
S
---
G
D
G
D
K
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
T
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
--
Q
F
V
V
C
S
P
--
R
QE
E
S
W
R
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
Y
G
P
N
L
R
Q
N
-----
V
K
-----
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
E
M
I
R
F
E
13
PsiBlast_PDB
76.16
32%
-67
- C2 -
3LSQ
2
?
A:
[7-468]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
D
E
T
G
--
A
N
I
I
R
E
S
Q
R
R
R
F
A
D
--
P
D
I
--
V
D
-
A
I
I
---
E
A
D
K
K
W
R
R
T
Q
F
L
T
--------
E
A
S
K
K
L
I
N
I
C
S
K
A
V
G
A
K
K
K
A
KEA----------------------------------------------------------
V
L
Q
L
K
Q
L
S
K
D
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
I
A
Q
D
E
-
E
T
G
N
T
V
V
R
T
F
G
N
T
T
K
R
--------------------
A
--------------------
K
L
N
---
H
V
S
I
M
E
R
L
G
M
M
D
T
S
-
K
A
V
T
S
M
A
-
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
E
E
L
Y
Q
V
--
S
GDG
D
--
K
K
Y
-
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
T
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
-------
L
G
I
F
R
V
H
Q
F
D
K
I
E
--
Q
F
V
V
C
S
P
RQ
E
--
E
S
W
R
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
Y
G
P
N
L
R
-
G
-----
T
A
AQN
V
K
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
E
M
I
R
F
E
14
PsiBlast_PDB
76.13
32%
-64
- C2 -
3LSS
4
?
A:
[7-468]
-----------------------------------------------------------------------------------------------
V
L
D
I
Q
L
F
R
D
E
T
G
--
A
N
I
I
R
E
S
Q
R
R
R
F
A
D
--
P
D
I
--
V
D
-
A
I
I
---
E
A
D
K
K
W
R
R
T
Q
F
L
T
--------
E
A
S
K
K
L
I
N
I
C
S
K
A
V
G
A
K
K
K
A
KEA---------------------------------------------------------
C
V
L
Q
L
K
Q
L
S
K
D
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
I
A
Q
D
E
-
E
T
G
N
T
V
V
R
T
F
G
N
T
T
K
R
--------------------
A
--------------------
K
L
N
---
H
V
S
I
M
E
R
L
G
M
M
D
T
S
-
K
A
V
T
S
M
A
-
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
E
E
L
Y
Q
V
--
S
GD
G
D
--
K
K
Y
-
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
T
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
--
Q
F
V
V
C
S
P
RQ
E
--
E
S
W
R
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
Y
G
P
N
L
R
---------QN
V
K
-
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
E
M
I
R
F
E
6
PsiBlast_PDB
75.60
36%
-65
- C2 -
1SER
-
SYS_THET2
A:
[1-419]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
--
Q
E
--
P
E
V
F
H
R
A
I
R
E
K
G
V
A
--
L
D
L
--
E
A
-
L
L
A
---
L
D
R
-
E
V
Q
---------------------------------------------------------------------------------------------------------------------
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
-
A
--
N
R
E
I
K
R
V
G
-
G
P
P
E
--------------------
F
--------------------
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
--
A
---
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
--
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
P
-
E
-
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
-
E
V
L
E
P
C
25
PsiBlast_CBE
69.21
37%
-64
- C2 -
3ERR
1
SYS_THET2
B:
[169-528]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
A
-----------------
Q
L
-----
N
-----------------------------
Y
A
------
D
M
L
K
R
V
E
P
------
L
R
N
E
L
Q
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
--
A
-
N
R
E
I
K
R
V
G
-
G
P
P
E
--------------------
F
--------------------
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
--
A
---
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
QY
V
L
T
E
A
S
L
--
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
P
-
E
-
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
-
E
V
L
E
P
G
33
Fugue
69.10
33%
-52
- C2 -
3ERR
1
DYHC1_MOUSE (first)
A:
[3-529]
D
L
K
R
L
R
Q
E
P
E
V
F
H
R
A
I
R
E
K
GVALD
L
E
A
L
L
A
V
D
E
Q
L
H
K
Q
Q
E
V
I
A
D
K
Q
M
S
V
K
E
D
L
D
K
V
E
P
A
V
I
E
A
Q
N
A
V
K
S
IK
K
Q
H
L
V
E
V
R
S
MANPP
A
A
V
K
L
A
L
E
S
I
A
L
L
L
G
E
S
T
--
T
D
--
W
K
Q
I
R
S
I
I
M
R
E
N
F
I
--
P
T
I
--
V
N
F
S
A
E
---
E
I
S
D
A
I
R
E
K
M
K
K
N
YMSNPSYN
Y
E
I
V
N
R
A
S
L
A
A
G
P
M
V
-----------------
K
W
A
I
A
Q
L
N
-----------------------------
Y
A
------
D
M
L
K
R
V
E
P
------
L
R
N
E
L
Q
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
-
A
--
N
R
E
I
K
R
V
G
-
G
P
P
E
--------------------
F
--------------------
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
-
W
W
E
P
-
R
I
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
--
A
---
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
P
-
E
-
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
-
E
V
L
E
P
G
9
PsiBlast_PDB
68.30
37%
-62
- C2 -
3ERR
1
DYHC1_MOUSE (first)
A:
[169-528]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
A
-----------------
Q
L
-----
N
-----------------------------
Y
A
------
D
M
L
K
R
V
E
P
------
L
R
N
E
L
Q
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
--
A
-
N
R
E
I
K
R
V
G
-
G
P
P
E
--------------------
F
--------------------
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
--
W
E
P
R
I
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
--
A
---
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
--
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
P
-
E
-
G
-----
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
-
E
V
L
E
P
G
48
HHSearch
66.59
37%
-63
- C2 -
3ERR
1
DYHC1_MOUSE (first)
A:
[179-527]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
R
V
E
P
------
L
R
N
E
L
Q
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
--
A
-
N
R
E
I
K
R
V
G
-
G
P
P
E
--------------------
F
--------------------
S
F
P
P
L
D
H
V
A
L
M
E
K
N
G
W
W
E
P
--
R
I
S
-
Q
V
S
-
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
--
A
---
E
--
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
--
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
D
P
E
G
-------
R
V
-----
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
V
L
E
P
G
-