@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0421: (2015-11-30 )
MANRKETFLIDGMTCASCALTIEKAVNKLDHVDSAVVNLATEKMTVTFDDTTLSPNVIEECVSESGYEASLFKEETSKSQSERHQLAIEKMWHRFWMSAVATIPLLYISMGPMINLWLPSFLMPDKGPLNYGMIQLLLTLPVMYFGRIFYQNGFKALFKRHPNMDSLVAIATTAAFIYSLYGLYEILQGDIHYAHQLYFESVAVILTLITLGKYFEILSKGRTSASIEKLLTLSAKEARVIKDGEDYMVPLDKVKIGETILVKPGEKIPLDGHVVAGESSIDESMLTGESIPVEKKVGSKVYGASINGQGSLTIFVEKEAGGSLLSQIINLVEAAQTSKAPIANLADKVSGVFVPFVIVIAILSGLSWYLILGQSFAFSLKIMIAVLVIACPCALGLATPTAIMVASGKAAENGILFKGGEVLEKAHHIDTIVFDKTGTLTKGKPEVVAIKTYGGDKEEFLGQVASVEKLSNHPLSQTIVNKAKEKELPLREVMAFKNILGYGLSATINGKTMLVGNANLMTKNDVNLDLAKADIEIAQEEAQTVVYVSENGVLSGLITLTDQLKTDSQETVKQLQRLGFNLVLLTGDNKASADAIAQKLGITTVVSEVLPDQKANVILELKEKGGQIAMVGDGINDAPALASSDVGISMSSGTDIAIESADIVLMKPELTDLLKAMTISKQTIQIIKENLFWAFFYNVLAIPVAMGVLHLFGGPLLNPMLAGLAMAFSSVSVVLNALRLKVLK
Atome Classification :
(25 SA)
-.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140-...-.-...150.......160.......170.......180.......190....-------...200.......210.......220.......230.......240-.......250....--...260.......270......-.280-.........290...-------------...----------.300--------.........310.......320.......330.......340.......350.......360.......370.---------.-.....380.......390.......400.......410.......420.......430.......440..---.....450-------------------------------------------------...----..------------------------------.--------------------..-.460......-.----------------470......------------------------------------------.480.......490-----...-----.....------------------------.500....-..--.------510.........520-----...--...---------..---530---.........540--.......--------------------..550----------------------.-----------------------........560.......570.......580.......590.......600-----------------------------------------------------.-----------------------------------------------------......610.......620.......630.......640.......650........660.......670.......680.......690.-----------..-....700-----------.......710.......720......--------------.730.......740..---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MANR
K
E
T
F
L
IDG
M
T
C
A
S
C
A
L
T
I
E
K
A
V
N
K
L
D
H
V
D
S
A
V
V
N
LAT
E
K
M
T
V
T
FDDTTL
S
P
N
V
I
E
E
C
V
S
ESGYE
A
S
L
F
K
E
ETSK
S
Q
S
E
R
H
Q
L
A
I
E
K
M
W
H
R
F
W
M
S
A
V
A
T
I
P
L
L
Y
ISMG
P
M
I
N
LWL
P
S
FLMPDKGP
L
N
Y
G
M
I
Q
L
L
L
T
L
P
V
-
M
Y
F
-
G
-
R
I
F
Y
Q
N
G
F
K
A
L
F
K
RHP
N
M
D
S
L
V
A
I
A
T
T
A
A
F
I
Y
S
L
Y
G
L
Y
E
I
L
QG
D
I
H
Y
A
H
Q
-------
L
Y
F
E
S
V
A
V
I
L
T
L
I
T
L
G
K
Y
F
E
I
L
SKGR
T
S
A
S
I
E
K
L
L
TLSAK
E
A
R
V
IK-DGE
D
Y
M
V
PLDKVKI--G
E
T
I
L
VKPGEKIPLD
G
H
V
VAGE-SS---IDESMLTGESIPVEK-------------KVG----------S
K
----------
V
Y
G
A
S
INGQ
G
S
L
T
I
F
V
EKEA
G
G
S
L
L
S
Q
I
I
N
L
V
E
A
AQTSKA
P
I
A
N
L
A
D
K
VS
G
V
F
V
P
F
V
I
V
I
A
I
L
SGL
S
W
Y
L
I
LG---------Q-
S
F
A
F
S
L
K
I
M
I
A
V
L
V
I
ACPCALGLAT
P
T
A
I
M
V
ASGKAAEN
G
I
L
FK
G
G
E
V
L
E
KAHH
I
D
T
I
V
FDKTGTLTKGK---P
E
V
V
A
I
---------------------------------------------------
K
TY----GG------------------------------
D
--------------------
K
E
-
E
F
L
G
Q
V
A
S
V
E
-
K
----------------LSNHP
L
S
Q
T
------------------------------------------
I
V
N
K
A
KEKEL
P
L
-------
R
E
V
-----
M
A
F
K
N
------------------------
I
L
GYG
L
S
A
-
T
I--N------G--
K
T
M
L
V
GNA
N
L
M------TKN--DVN---------
L
D
---
L
-----AKA
D
I
E
I
A
QE----EA
Q
T
V
V
Y
--------------------VSE------------------------N-----------------------G
V
L
S
G
L
I
T
L
T
D
QLKTD
S
Q
E
T
V
K
Q
L
Q
RLG
F
N
L
V
L
L
TGDNKA
S
A
D
A
I
A
Q
KL
G
I
-----------------------------------------------------
T
-----------------------------------------------------
T
V
V
S
E
VLPDQKA
N
V
I
L
E
L
KEKG
G
Q
I
A
M
VGDGINDAPALASSDV
G
I
SMS-SG
T
D
I
A
I
ESA
D
I
V
L
MKP
E
L
T
D
L
L
K
A
MTI
S
K
Q
T
I
Q
I
I
K
EN
L
F
W
-----------
A
F
-
F
Y
N
V
L
A
I
-----------
P
V
A
M
G
V
L
H
LFGG
P
L
L
N
P
M
L
A
G
L
A
M
A
F
--------------
S
S
V
S
V
V
L
N
A
L
R
L
KVLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
89.24
42%
-89
- C3 -
3J09
-
COPA_ARCFU
A:
[15-729]
---
P
M
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
E
T
A
F
I
R
F
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
D
L
G
Y
G
V
V
D
E
Q
A
A
V
S
----
A
-
E
V
E
H
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
F
I
--------------
S
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
-
G
-
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
-----
V
L
P
R
E
Y
-------
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
--
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
---
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
-------------
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
H
---------
A
-
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
---
P
E
V
T
D
L
---------------------------------------------------
V
P
L
----
N
G
------------------------------
D
--------------------
E
R
-
E
L
L
R
L
A
A
I
A
E
-
R
----------------
R
S
E
H
P
I
A
E
A
------------------------------------------
I
V
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
-----
E
K
V
E
V
------------------------
I
A
G
E
G
V
V
A
---------------
D
G
I
L
V
G
N
K
R
L
M
------
E
D
F
--
G
V
A
---------
V
S
---
N
E
----
V
E
L
A
L
E
K
L
E
R
----
E
A
K
T
A
V
I
--------------------
V
A
R
------------------------
N
-----------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
-----------
A
L
-
I
Y
N
V
I
L
I
-----------
P
A
A
A
G
L
L
Y
P
I
F
G
V
V
F
R
P
E
F
A
G
L
A
M
A
M
--------------
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
88.61
40%
-91
- C3 -
3J09
-
COPA_ARCFU
A:
[17-726]
-----
E
R
T
V
R
V
T
G
M
T
C
A
M
C
V
K
S
I
E
T
A
V
G
S
L
E
G
V
E
E
V
R
V
N
L
A
T
E
T
A
F
I
R
F
D
E
K
R
I
D
F
E
T
I
K
R
V
I
E
D
L
G
Y
--
G
V
V
D
E
Q
A
A
V
S
A
E
V
E
H
---
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
--
F
I
S
L
P
Y
E
D
F
------------
V
Q
L
L
I
A
L
P
A
-
I
F
Y
S
G
-
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
V
L
P
R
E
Y
S
F
------------
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
--
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
---
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
-------------
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
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D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
H
---------
A
-
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
---
P
E
V
T
D
L
---------------------------------------------------
V
P
L
----
N
G
------------------------------
D
--------------------
E
R
-
E
L
L
R
L
A
A
I
A
E
-
R
----------------
R
S
E
H
P
I
A
E
A
------------------------------------------
I
V
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
-----
E
K
V
E
V
------------------------
I
A
G
E
G
V
V
A
---------------
D
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
S
N
--
E
V
E
---------
L
A
---
L
-----
E
K
-----
L
E
R
----
E
A
K
T
A
V
I
--------------------
V
A
R
------------------------
N
-----------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
-----------
A
L
-
I
Y
N
V
I
L
I
-----------
P
A
A
A
G
L
L
Y
P
I
F
G
V
V
F
R
P
E
F
A
G
L
A
M
A
M
--------------
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.83
42%
-97
- C3 -
4BYG
4
?
A:
[81-732]
-------------------------------------------------------------------------------------------
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
---
G
H
G
L
K
H
F
I
S
G
N
----
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
-
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
--
L
W
P
G
V
F
P
H
A
F
R
SQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
--
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
---
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
---------
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
---
P
K
L
T
R
I
---------------------------------------------------
V
T
D
----
D
F
------------------------------
V
--------------------
E
D
-
N
A
L
A
L
A
A
A
L
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
------------------------------------------
I
V
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
-----
E
A
F
E
A
------------------------
P
T
G
K
G
V
V
G
-
Q
V
--
D
------
G
--
H
H
V
A
I
G
N
A
R
L
M
------
Q
E
H
G
G
D
N
A
---------
P
L
---
F
-----
E
K
A
D
-
E
L
R
G
K
----
G
A
-
S
V
M
F
--------------------
M
A
V
------------------------
D
-----------------------
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
-----------
A
F
-
I
Y
N
V
L
G
V
-----------
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
--------------
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
85.06
42%
-94
- C3 -
3RFU
3
?
A:
[74-736]
------------------------------------------------------------------------------------
V
S
P
E
Y
L
D
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
---
G
H
G
L
K
H
F
I
S
G
N
----
G
S
S
W
I
Q
L
L
L
A
T
P
V
-
V
L
W
-
G
G
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
L
--
W
P
G
V
F
P
H
A
F
R
SQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
--
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
---
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
---------
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
---
P
K
L
T
R
I
---------------------------------------------------
V
T
D
----
D
F
------------------------------
V
--------------------
E
D
-
N
A
L
A
L
A
A
A
L
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
------------------------------------------
I
V
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
-----
E
A
F
E
A
------------------------
P
T
G
K
G
V
V
G
-
Q
V
--
D
------
G
--
H
H
V
A
I
G
N
A
R
L
M
------
Q
E
H
--
G
G
D
---------
N
A
---
P
-----
L
F
E
K
A
D
E
L
R
G
----
K
G
A
S
V
M
F
--------------------
M
A
V
------------------------
D
-----------------------
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
-----------
A
F
-
I
Y
N
V
L
G
V
-----------
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
--------------
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
L--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.90
42%
-95
- C3 -
4BEV
2
?
A:
[81-732]
-------------------------------------------------------------------------------------------
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
---
G
H
G
L
K
H
F
I
S
G
N
----
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
-
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
--
L
W
P
G
V
F
P
H
A
F
R
SQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
--
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
---
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
---------
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
---
P
K
L
T
R
I
---------------------------------------------------
V
T
D
----
D
F
------------------------------
V
--------------------
E
D
-
N
A
L
A
L
A
A
A
L
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
------------------------------------------
I
V
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
-----
E
A
F
E
A
------------------------
P
T
G
K
G
V
V
G
-
Q
V
--
D
------
G
--
H
H
V
A
I
G
N
A
R
L
M
------
Q
E
H
G
G
D
N
A
---------
P
L
---
F
-----
E
K
A
D
-
E
L
R
G
K
----
G
A
-
S
V
M
F
--------------------
M
A
V
------------------------
D
-----------------------
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
-----------
A
F
-
I
Y
N
V
L
G
V
-----------
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
--------------
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
84.42
42%
-96
- C3 -
3RFU
3
?
B:
[81-732]
-------------------------------------------------------------------------------------------
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
---
G
H
G
L
K
H
F
I
S
G
N
----
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
-
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
--
L
W
P
G
V
F
P
H
A
F
R
SQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
--
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
---
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
---------
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
---
P
K
L
T
R
I
---------------------------------------------------
V
T
D
----
D
F
------------------------------
V
--------------------
E
D
-
N
A
L
A
L
A
A
A
L
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
------------------------------------------
I
V
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
-----
E
A
F
E
A
------------------------
P
T
G
K
G
V
V
G
-
Q
V
--
D
------
G
--
H
H
V
A
I
G
N
A
R
L
M
------
Q
E
H
GG
D
N
A
---------
P
L
---
F
-----
E
K
A
D
-
E
L
R
G
K
----
G
A
-
S
V
M
F
--------------------
M
A
V
------------------------
D
-----------------------
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
-----------
A
F
-
I
Y
N
V
L
G
V
-----------
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
--------------
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
84.30
42%
-96
- C3 -
3RFU
3
?
A:
[81-732]
-------------------------------------------------------------------------------------------
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
---
G
H
G
L
K
H
F
I
S
G
N
----
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
-
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
--
L
W
P
G
V
F
P
H
A
F
R
SQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
--
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
---
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
---------
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
---
P
K
L
T
R
I
---------------------------------------------------
V
T
D
----
D
F
------------------------------
V
--------------------
E
D
-
N
A
L
A
L
A
A
A
L
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
------------------------------------------
I
V
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
-----
E
A
F
E
A
------------------------
P
T
G
K
G
V
V
G
-
Q
V
--
D
------
G
--
H
H
V
A
I
G
N
A
R
L
M
------
Q
E
H
G
G
D
N
A
---------
P
L
---
F
-----
E
K
A
D
-
E
L
R
G
K
----
G
A
-
S
V
M
F
--------------------
M
A
V
------------------------
D
-----------------------
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
-----------
A
F
-
I
Y
N
V
L
G
V
-----------
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
--------------
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
84.23
42%
-96
- C3 -
3RFU
3
?
C:
[81-732]
-------------------------------------------------------------------------------------------
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
---
G
H
G
L
K
H
F
I
S
G
N
----
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
-
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
--
L
W
P
G
V
F
P
H
A
F
R
SQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
--
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
---
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
---------
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
---
P
K
L
T
R
I
---------------------------------------------------
V
T
D
----
D
F
------------------------------
V
--------------------
E
D
-
N
A
L
A
L
A
A
A
L
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
------------------------------------------
I
V
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
-----
E
A
F
E
A
------------------------
P
T
G
K
G
V
V
G
-
Q
V
--
D
------
G
--
H
H
V
A
I
G
N
A
R
L
M
------
Q
E
H
GG
D
N
A
---------
P
L
---
F
-----
E
K
A
D
-
E
L
R
G
K
----
G
A
-
S
V
M
F
--------------------
M
A
V
------------------------
D
-----------------------
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
-----------
A
F
-
I
Y
N
V
L
G
V
-----------
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
--------------
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
84.21
42%
-96
- C3 -
3RFU
3
?
D:
[81-732]
-------------------------------------------------------------------------------------------
M
R
R
R
F
W
I
A
L
M
L
T
I
P
V
V
I
L
E
M
G
---
G
H
G
L
K
H
F
I
S
G
N
----
G
S
S
W
I
Q
L
L
L
A
T
P
V
V
L
W
G
-
G
-
W
P
F
F
K
R
G
W
Q
S
L
K
T
G
Q
L
N
M
F
T
L
I
A
M
G
I
G
V
A
W
I
Y
S
M
V
A
V
--
L
W
P
G
V
F
P
H
A
F
R
SQEGVVA
V
Y
F
E
A
A
A
V
I
T
T
L
V
L
L
G
Q
V
L
E
L
K
A
R
E
Q
T
G
S
A
I
R
A
L
L
K
L
V
P
E
S
A
H
R
I
K
E
D
G
S
E
E
E
V
S
L
D
N
V
A
V
--
G
D
L
L
R
V
R
P
G
E
K
I
P
V
D
G
E
V
Q
E
G
R
-
S
F
---
V
D
E
S
M
V
T
G
E
P
I
P
V
A
K
-------------
E
A
S
----------
A
K
----------
V
I
G
A
T
I
N
Q
T
G
S
F
V
M
K
A
L
H
V
G
S
D
T
M
L
A
R
I
V
Q
M
V
S
D
A
Q
R
S
R
A
P
I
Q
R
L
A
D
T
V
S
G
W
F
V
P
A
V
I
L
V
A
V
L
S
F
I
V
W
A
L
L
G
P
---------
Q
P
A
L
S
Y
G
L
I
A
A
V
S
V
L
I
I
A
C
P
C
A
L
G
L
A
T
P
M
S
I
M
V
G
V
G
K
G
A
Q
S
G
V
L
I
K
N
A
E
A
L
E
R
M
E
K
V
N
T
L
V
V
D
K
T
G
T
L
T
E
G
H
---
P
K
L
T
R
I
---------------------------------------------------
V
T
D
----
D
F
------------------------------
V
--------------------
E
D
-
N
A
L
A
L
A
A
A
L
E
-
H
----------------
Q
S
E
H
P
L
A
N
A
------------------------------------------
I
V
H
A
A
K
E
K
G
L
S
L
-------
G
S
V
-----
E
A
F
E
A
------------------------
P
T
G
K
G
V
V
G
-
Q
V
--
D
------
G
--
H
H
V
A
I
G
N
A
R
L
M
------
Q
E
H
GG
D
N
A
---------
P
L
---
F
-----
E
K
A
D
-
E
L
R
G
K
----
G
A
-
S
V
M
F
--------------------
M
A
V
------------------------
D
-----------------------
G
K
T
V
A
L
L
V
V
E
D
P
I
K
S
S
T
P
E
T
I
L
E
L
Q
Q
S
G
I
E
I
V
M
L
T
G
D
S
K
R
T
A
E
A
V
A
G
T
L
G
I
-----------------------------------------------------
K
-----------------------------------------------------
K
V
V
A
E
I
M
P
E
D
K
S
R
I
V
S
E
L
K
D
K
G
L
I
V
A
M
A
G
D
G
V
N
D
A
P
A
L
A
K
A
D
I
G
I
A
M
G
-
T
G
T
D
V
A
I
E
S
A
G
V
T
L
L
H
G
D
L
R
G
I
A
K
A
R
R
L
S
E
S
T
M
S
N
I
R
Q
N
L
F
F
-----------
A
F
-
I
Y
N
V
L
G
V
-----------
P
L
A
A
G
V
L
Y
P
L
T
G
L
L
L
S
P
M
I
A
A
A
A
M
A
L
--------------
S
S
V
S
V
I
I
N
A
L
R
L
K
R
V
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.28
42%
-94
- C3 -
3J08
-
COPA_ARCFU
A:
[95-726]
----------------------------------------------------------------------------------------
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
--
F
I
S
L
P
Y
E
D
F
------------
V
Q
L
L
I
A
L
P
A
-
I
F
Y
S
G
-
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
V
L
P
R
E
Y
S
F
------------
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
--
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
---
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
-------------
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
H
---------
A
-
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
---
P
E
V
T
D
L
---------------------------------------------------
V
P
L
----
N
G
------------------------------
D
--------------------
E
R
-
E
L
L
R
L
A
A
I
A
E
-
R
----------------
R
S
E
H
P
I
A
E
A
------------------------------------------
I
V
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
-----
E
K
V
E
V
------------------------
I
A
G
E
G
V
V
A
---------------
D
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
S
N
--
E
V
E
---------
L
A
---
L
-----
E
K
-----
L
E
R
----
E
A
K
T
A
V
I
--------------------
V
A
R
------------------------
N
-----------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
-----------
A
L
-
I
Y
N
V
I
L
I
-----------
P
A
A
A
G
L
L
Y
P
I
F
G
V
V
F
R
P
E
F
A
G
L
A
M
A
M
--------------
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
81.63
43%
-91
- C3 -
3J08
-
COPA_ARCFU
A:
[95-728]
----------------------------------------------------------------------------------------
L
S
R
M
K
R
K
L
Y
V
A
A
F
A
G
V
L
L
L
F
L
A
H
F
I
S
--------------
L
P
Y
E
D
F
V
Q
L
L
I
A
L
P
A
I
F
Y
S
-
G
-
S
S
I
F
K
A
A
F
S
A
L
R
R
R
T
L
N
M
D
V
M
Y
S
M
G
V
G
A
A
F
L
A
S
V
L
S
T
A
G
-----
V
L
P
R
E
Y
-------
S
F
Y
E
T
S
V
L
L
L
A
F
L
L
L
G
R
T
L
E
A
R
A
K
S
R
T
G
E
A
I
K
K
L
V
G
L
Q
A
K
T
A
V
V
I
R
-
D
G
K
E
I
A
V
P
V
E
E
V
A
V
--
G
D
I
V
I
V
R
P
G
E
K
I
P
V
D
G
V
V
V
E
G
E
-
S
Y
---
V
D
E
S
M
I
S
G
E
P
V
P
V
L
K
-------------
S
K
G
----------
D
E
----------
V
F
G
A
T
I
N
N
T
G
V
L
K
I
R
A
T
R
V
G
G
E
T
L
L
A
Q
I
V
K
L
V
E
D
A
M
G
S
K
P
P
I
Q
R
L
A
D
K
V
V
A
Y
F
I
P
T
V
L
L
V
A
I
S
A
F
I
Y
W
Y
F
I
A
H
---------
A
-
P
L
L
F
A
F
T
T
L
I
A
V
L
V
V
A
C
P
C
A
F
G
L
A
T
P
T
A
L
T
V
G
M
G
K
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
---
P
E
V
T
D
L
---------------------------------------------------
V
P
L
----
N
G
------------------------------
D
--------------------
E
R
-
E
L
L
R
L
A
A
I
A
E
-
R
----------------
R
S
E
H
P
I
A
E
A
------------------------------------------
I
V
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
-----
E
K
V
E
V
------------------------
I
A
G
E
G
V
V
A
---------------
D
G
I
L
V
G
N
K
R
L
M
------
E
D
F
--
G
V
A
---------
V
S
---
N
E
----
V
E
L
A
L
E
K
L
E
R
----
E
A
K
T
A
V
I
--------------------
V
A
R
------------------------
N
-----------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
K
Q
N
I
F
W
-----------
A
L
-
I
Y
N
V
I
L
I
-----------
P
A
A
A
G
L
L
Y
P
I
F
G
V
V
F
R
P
E
F
A
G
L
A
M
A
M
--------------
S
S
V
S
V
V
A
N
S
L
L
L
R
N
Y
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.50
31%
-93
- C3 -
4UMW
2
?
A:
[124-728]
-------------------------------------------------------------------------------------
R
L
K
-------------
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
F
N
H
P
------
F
G
Q
L
A
F
I
A
T
T
L
V
-
G
-------
L
Y
P
I
A
R
Q
A
L
--
R
L
I
K
S
G
S
Y
F
A
I
E
T
----
L
M
S
V
A
A
I
G
A
L
F
I
G
A
T
A
E
A
---------------
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
----
V
S
A
L
M
A
L
K
P
E
T
A
T
R
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
--
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
---
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
-------------
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
A
---------
A
-
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
---
P
R
V
T
A
I
---------------------------------------------------
H
P
A
----
T
G
------------------------------
I
--------------------
S
E
S
E
L
L
T
L
A
A
A
V
E
-
Q
----------------
G
A
T
H
P
L
A
Q
A
------------------------------------------
I
V
R
E
A
Q
V
A
E
L
A
I
-------
P
T
A
-----
E
S
Q
R
A
------------------------
L
V
G
S
G
I
E
A
-
Q
V
--
N
------
G
--
E
R
V
L
I
C
A
A
G
K
H
------
P
A
----------------
D
---
A
-----
F
A
G
L
I
N
E
L
E
S
----
A
G
Q
T
V
V
L
--------------------
V
V
R
------------------------
N
-----------------------
D
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------------------------------------------------------------------------
E
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
-
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
-----------
A
L
G
L
K
G
I
F
L
V
-----------
T
T
L
L
G
M
T
G
L
W
--------
L
A
V
L
A
D
T
G
--------------
A
T
V
L
V
T
A
N
A
L
R
L
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
76.24
32%
-86
- C3 -
4UMW
2
?
A:
[124-730]
------------------------------------------------------------------------------
R
L
K
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
F
N
--------
H
P
F
G
Q
L
A
F
I
A
T
T
L
V
G
L
Y
P
I
A
R
Q
A
L
R
L
I
K
S
----------------------
G
S
Y
F
A
I
E
T
L
M
S
V
A
A
I
G
A
L
F
I
G
-------------------------
A
T
A
E
A
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
V
----
S
A
L
M
A
L
K
P
E
T
A
T
R
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
--
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
---
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
-------------
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
A
---------
A
-
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
---
P
R
V
T
A
I
---------------------------------------------------
H
P
A
----
T
G
I-----------------------------
S
--------------------
E
S
-
E
L
L
T
L
A
A
A
V
E
-
Q
----------------
G
A
T
H
P
L
A
Q
A
------------------------------------------
I
V
R
E
A
Q
V
A
E
L
A
I
-------
P
T
A
-----
E
S
Q
R
A
------------------------
L
V
G
S
G
I
E
A
-
Q
V
--
N
------
G
--
E
R
V
L
I
C
A
A
G
K
H
------
P
A
----------------
D
---
A
-----
F
A
G
L
I
N
E
L
E
S
----
A
G
Q
T
V
V
L
--------------------
V
V
R
------------------------
N
-----------------------
D
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------------------------------------------------------------------------
E
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
A
-
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
-----------
A
L
-
G
L
K
G
I
F
L
-----------
V
T
T
L
L
-------
G
M
T
G
L
W
L
A
V
L
A
D
T
G
--------------
A
T
V
L
V
T
A
N
A
L
R
L
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
70.69
31%
-83
- C3 -
4UMV
2
?
A:
[126-728]
---------------------------------------------------------------------------------------
K
-------------
E
N
L
P
L
I
T
L
I
V
M
M
A
I
S
W
G
L
E
Q
F
N
H
P
------
F
G
Q
L
A
F
I
A
T
T
L
V
-
G
-------
L
Y
P
I
A
R
Q
A
L
--
R
L
I
K
S
G
S
Y
F
A
I
E
T
----
L
M
S
V
A
A
I
G
A
L
F
I
G
A
T
A
E
A
---------------
A
M
V
L
L
L
F
L
I
G
E
R
L
E
G
W
A
A
S
R
A
R
Q
G
V
S
A
L
M
A
L
K
P
E
T
A
T
R
L
R
-
N
G
E
R
E
E
V
A
I
N
S
L
R
P
--
G
D
V
I
E
V
A
A
G
G
R
L
P
A
D
G
K
L
L
S
P
F
-
A
S
---
F
D
E
S
A
L
T
G
E
S
I
P
V
E
R
-------------
A
T
G
----------
D
K
----------
V
P
A
G
A
T
S
V
D
R
L
V
T
L
E
V
L
S
E
P
G
A
S
A
I
D
R
I
L
K
L
I
E
E
A
E
E
R
R
A
P
I
E
R
F
I
D
R
F
S
R
I
Y
T
P
A
I
M
A
V
A
L
L
V
T
L
V
P
P
L
L
F
A
---------
A
-
S
W
Q
E
W
I
Y
K
G
L
T
L
L
L
I
G
C
P
C
A
L
V
I
S
T
P
A
A
I
T
S
G
L
A
A
A
A
R
R
G
A
L
I
K
G
G
A
A
L
E
Q
L
G
R
V
T
Q
V
A
F
D
K
T
G
T
L
T
V
G
K
---
P
R
V
T
A
I
---------------------------------------------------
H
P
A
----
T
G
------------------------------
I
--------------------
S
E
S
E
L
L
T
L
A
A
A
V
E
-
Q
----------------
G
A
T
H
P
L
A
Q
A
------------------------------------------
I
V
R
E
A
Q
V
A
E
L
A
I
-------
P
T
A
-----
E
S
Q
R
A
------------------------
L
V
G
S
G
I
E
A
-
Q
V
--
N
------
G
--
E
R
V
L
I
C
A
A
G
K
H
------
P
A
----------------
D
---
A
-----
F
A
G
L
I
N
E
L
E
S
----
A
G
Q
T
V
V
L
--------------------
V
V
R
------------------------
N
-----------------------
D
D
V
L
G
I
I
A
L
Q
D
T
L
R
A
D
A
A
T
A
I
S
E
L
N
A
L
G
V
K
G
V
I
L
T
G
D
N
P
R
A
A
A
A
I
A
G
E
L
G
L
-----------------------------------------------------------------------------------------------------------
E
F
K
A
G
L
L
P
E
D
K
V
K
A
V
T
K
L
N
Q
H
-
A
P
L
A
M
V
G
D
G
I
N
D
A
P
A
M
K
A
A
A
I
G
I
A
M
G
-
S
G
T
D
V
A
L
E
T
A
D
A
A
L
T
H
N
H
L
R
G
L
V
Q
M
I
E
L
A
R
A
T
H
A
N
I
R
Q
N
I
T
I
-----------
A
L
G
L
K
G
I
F
L
V
-----------
T
T
L
L
G
M
T
G
L
W
--------
L
A
V
L
A
D
T
G
--------------
A
T
V
L
V
T
A
N
A
L
R
L
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Fugue
67.43
20%
-78
- C1 -
1SU4
3
AT2A1_RABIT
A:
[1-994]
-
M
E
A
-------------------------------------------------
A
H
S
K
S
T
E
E
C
L
A
Y
-------
F
G
V
S
E
T
T
G
L
T
P
D
Q
V
K
R
H
L
E
K
Y
G
H
N
E
L
P
A
E
E
G
K
S
L
W
E
L
V
I
-----------------------------------------------------
E
Q
F
E
D
L
L
V
R
I
L
L
L
A
A
C
I
S
F
V
L
A
W
F
E
E
G
E
E
T
-----
I
-------
T
A
F
V
E
P
F
V
I
L
L
I
L
I
A
N
A
I
V
G
V
W
Q
E
R
N
A
E
N
A
I
E
A
L
K
E
Y
E
P
E
M
G
K
V
Y
R
-
A
D
R
K
S
V
Q
R
I
K
A
R
D
I
VP
G
D
I
V
E
V
A
V
G
D
K
V
P
A
D
I
R
I
L
S
I
K
-
S
T
T
L
R
V
D
Q
S
I
L
T
G
E
S
V
S
V
I
K
H
TEPVPDPRAVNQ
D
K
K
----------
N
M
----------
L
F
S
G
T
N
I
A
A
G
K
A
L
G
I
V
A
T
T
G
V
S
T
E
I
G
K
I
R
D
Q
M
A
A
T
E
Q
D
K
T
P
L
Q
Q
K
L
D
E
F
G
E
Q
L
S
K
V
I
S
L
I
C
V
A
V
W
L
I
N
I
G
H
F
N
DPVHGGSWI
R
-
G
A
I
Y
Y
F
K
I
A
V
A
L
A
V
A
A
I
P
E
G
L
P
A
V
I
T
T
C
L
A
L
G
T
R
R
M
A
K
K
N
A
I
V
R
S
L
P
S
V
E
T
L
G
C
T
S
V
I
C
S
D
K
T
G
T
L
T
T
N
Q
M
S
V
C
K
M
F
I
I
---------------------------------------------------
D
K
V
----
D
G
D
F
C
S
L
N
E
F
S
I
T
G
S
T
YAP
E
G
E
V
L
K
ND
K
P
I
R
S
G
--------------------
Q
F
-
D
G
L
V
E
L
A
T
I
C
-
A
----------------
L
C
N
D
S
S
L
D
F
NETKG
V
Y
E
K
V
G
E
A
T
E
T
A
L
T
T
L
V
E
K
M
NVFNTEVRNLSKVERAN
A
C
N
S
V
I
R
Q
L
M
K
K
-------
E
F
T
-----
L
E
F
S
R
DRK
S
M
S
V
Y
C
S
PAKSSRAAVG
N
K
M
F
V
K
G
A
P
E
G
V
-
I
D
--
R
------
C
--
N
Y
V
R
V
G
T
T
R
V
P
------
M
T
G
--
P
V
K
---------
E
K
---
I
-----
L
S
V
I
K
E
W
G
T
G
RDT
L
R
C
L
A
L
A
T
RDTPPKREEMVLDDSSR
F
M
E
Y
E
T
------------------------
D
-----------------------
L
T
F
V
G
V
V
G
M
L
D
P
P
R
K
E
V
M
G
S
I
Q
L
C
R
D
A
G
I
R
V
I
M
I
T
G
D
N
K
G
T
A
I
A
I
C
R
R
I
G
I
FGENEEVADRAYT
G
R
E
F
D
D
LP
L
A
E
Q
R
E
A
C
R
R
----------------------
A
-----------------------------------------------------
C
C
F
A
R
V
E
P
S
H
K
S
K
I
V
E
Y
L
Q
S
Y
D
E
I
T
A
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
E
I
G
I
A
M
G
-
S
G
T
A
V
A
K
T
A
S
E
M
V
L
A
D
D
N
F
S
T
I
V
A
A
V
E
E
G
R
A
I
Y
N
N
M
K
Q
F
I
R
Y
L
I
S
S
N
V
G
E
V
V
C
I
F
-
L
T
A
A
L
G
L
-----------
P
E
A
L
I
P
V
Q
L
L
W
V
N
L
V
T
D
G
L
P
A
T
A
L
G
F
NPPDLDIMDRPPRS
P
K
E
P
L
I
S
G
W
L
F
F
R
Y
M
A
I
G
G
Y
V
G
A
A
T
V
G
A
A
A
W
W
F
MYAEDGPGVTYHQLTHFMQCTEDHPHFEGLDCEIFEAP
E
P
M
T
M
A
L
S
V
L
V
T
I
E
M
C
N
A
L
N
S
LSENQSLMRMPPWVN
I
W
L
L
G
S
I
C
L
S
M
S
L
H
F
L
I
L
YV
D
P
L
P
M
I
F
K
L
K
A
L
D
L
T
Q
W
L
M
V
L
K
I
S
L
P
V
I
G
L
D
E
I
L
K
F
I
A
R
N
YLEG----------------------------
66
Fugue
63.11
19%
-74
- C3 -
3B8E
6
AT1A1_PIG
A:
[1-998]
A
K
K
E
R
D
M
D
E
L
K
K
E
V
S
M
D
D
H
K
L
S
L
D
E
L
H
R
K
Y
G
----------------
T
D
L
S
R
G
L
T
P
A
R
A
A
E
I
L
A
R
D
G
----------------------------------------------------
P
N
A
L
T
P
P
P
T
T
P
E
W
V
K
F
C
----------------------------
R
Q
L
F
G
G
F
S
M
L
L
W
I
G
A
I
L
C
F
L
A
--
Y
G
I
Q
A
A
T
E
E
E
P
Q
N
-------
D
N
L
Y
L
G
V
V
L
S
A
V
V
I
I
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
K
I
M
E
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
-
N
G
E
K
M
S
I
N
A
E
E
V
V
V
--
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
N
G
C
K
---
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
-------------
S
P
D
----------
F
T
N
ENPLETRNI
A
F
F
S
T
N
C
V
E
G
T
A
R
G
I
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
G
G
Q
T
P
I
A
A
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
-
S
L
I
L
E
---------
Y
-
T
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
---
M
T
V
A
H
M
WSDN
Q
I
H
E
A
DTTENQSGVSFDKTS
A
T
W
L
A
L
S
R
I
A
G
LCNR
A
V
F
Q
A
NQENLPI
L
K
R
----
A
V
------------------------------
A
--------------------
G
D
-
A
S
E
S
A
L
L
K
C
I
-
E
----------------
L
C
C
G
S
V
K
E
M
------------------------------------------
R
E
R
Y
T
K
I
V
E
I
P
F
NSTN
K
--
Y
Q
L
-----
S
I
H
K
N
PNTAEPR
H
L
---------------
L
V
M
K
G
A
P
E
-
R
I
L
D
R
------
C
--
S
S
I
L
I
H
G
K
E
Q
P
------
L
D
E
--
E
L
K
---------
D
A
---
F
-----
Q
N
A
Y
L
E
L
G
G
L
----
G
E
R
V
L
G
F
--------------------
C
H
L
------------------------
F
L
P
DEQFPEGF
Q
F
D
T
DDVNFPLDN
L
C
F
V
G
L
I
S
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
ISEGN
E
T
V
E
D
IAARLNIPVSQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
MT
S
E
Q
L
D
D
I
L
K
YHT
E
-----------------------------------------------------
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
S
K
K
A
D
I
G
V
A
M
G
I
A
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
-----------
T
L
-
T
S
N
I
P
E
I
T
P
F
L
I
F
I
I
ANI
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
T
D
M
V
P
A
I
S
L
A
Y
--------------
E
Q
A
E
S
D
I
M
K
R
Q
P
R
N
P
K
TDKLVN
E
Q
L
I
S
M
A
YGQ
I
G
M
I
Q
A
L
G
G
F
F
T
Y
F
V
I
L
A
E
N
GFLPIHLL
G
L
R
V
N
WDDRWINDVEDSYG
Q
Q
W
T
Y
EQRKIVEFT
C
H
T
P
F
F
V
T
I
V
V
V
Q
W
A
D
L
V
I
C
KTRRNSVFQQGMKN
K
I
L
I
F
G
L
F
E
E
T
A
L
A
A
F
L
S
Y
CPGMGVA
L
R
M
Y
P
LKPTWWFCAFPY
S
L
L
I
F
V
Y
D
E
V
R
K
L
I
I
R
R
RPGGW
V
E
K
E
T
YY
41
HHSearch
60.26
19%
-60
- C3 -
2ZXE
5
?
A:
[137-794]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
V
V
L
S
T
V
V
I
V
T
G
C
F
S
Y
Y
Q
E
A
K
S
S
R
I
M
D
S
F
K
N
M
V
P
Q
Q
A
L
V
I
R
-
D
G
E
K
S
T
I
N
A
E
F
V
V
A
--
G
D
L
V
E
V
K
G
G
D
R
I
P
A
D
L
R
I
I
S
A
H
G
C
K
---
V
D
N
S
S
L
T
G
E
S
E
P
Q
T
R
-------------
S
P
E
FSSENPLETR
N
I
----------
A
F
F
S
T
N
C
V
E
G
T
A
R
G
V
V
V
Y
T
G
D
R
T
V
M
G
R
I
A
T
L
A
S
G
L
E
V
G
R
T
P
I
A
I
E
I
E
H
F
I
H
I
I
T
G
V
A
V
F
L
G
V
S
F
F
I
L
S
L
I
L
-
G
---------
Y
-
S
W
L
E
A
V
I
F
L
I
G
I
I
V
A
N
V
P
E
G
L
L
A
T
V
T
V
C
L
T
L
T
A
K
R
M
A
R
K
N
C
L
V
K
N
L
E
A
V
E
T
L
G
S
T
S
T
I
C
S
D
K
T
G
T
L
T
Q
N
R
---
M
T
V
A
H
M
---------------------------------------------------
W
F
D
----
N
Q
------------------------------
I
H
E
A
DTTENQSGAAFDKTS
A
T
W
S
-
A
L
S
R
I
A
A
L
C
N
-
R
A
V
F
Q
A
GQDNVPILKRS
V
A
G
D
A
S
E
S
A
------------------------------------------
L
L
K
C
I
E
L
C
C
G
S
V
Q
G
M
R
D
R
N
P
K
I
-----
V
E
I
P
F
------------------------
N
S
T
N
K
Y
Q
L
S
I
H
--
E
NEKSSE
S
R
Y
L
L
V
M
K
G
A
P
E
R
I
------
L
D
R
--
C
S
T
ILLNG
A
E
E
P
L
K
---
E
D
M
K
E
A
F
Q
N
A
Y
L
E
L
G
G
----
L
G
E
R
V
L
G
--------------------
F
C
H
F
ALPEDKYNEG
Y
P
F
D
ADEPNFPTT
D
-----------------------
L
C
F
V
G
L
M
A
M
I
D
P
P
R
A
A
V
P
D
A
V
G
K
C
R
S
A
G
I
K
V
I
M
V
T
G
D
H
P
I
T
A
K
A
I
A
K
G
V
G
I
-----------------------------------------------------
I
SEGNET
I
E
D
I
A
A
R
L
NIPIGQVNPRDAK
A
C
V
V
H
G
S
D
L
K
D
LS
T
E
V
L
D
D
I
L
H
Y
H
T
E
I
V
F
A
R
T
S
P
Q
Q
K
L
I
I
V
E
G
C
Q
R
Q
G
A
I
V
A
V
T
G
D
G
V
N
D
S
P
A
L
K
K
A
D
I
G
V
A
M
G
I
S
G
S
D
V
S
K
Q
A
A
D
M
I
L
L
D
D
N
F
A
S
I
V
T
G
V
E
E
G
R
L
I
F
D
N
L
K
K
S
I
A
Y
-----------
T
L
-
T
S
N
I
P
E
I
-----------
T
P
F
L
V
F
I
I
G
N
V
P
L
P
L
G
T
V
T
I
L
C
I
D
L
G
--------------
T
D
M
V
P
A
I
S
L
A
Y
E
Q
A
E
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
56.29
42%
-65
- C3 -
3A1D
2
?
B:
[13-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
---
P
E
V
T
D
L
---------------------------------------------------
V
P
L
----
N
G
------------------------------
D
--------------------
E
R
-
E
L
L
R
L
A
A
I
A
E
-
R
----------------
R
S
E
H
P
I
A
E
A
------------------------------------------
I
V
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
-----
E
K
V
E
V
------------------------
I
A
G
E
G
V
V
A
-
D
--------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
S
N
--
E
V
E
---------
L
A
---
L
-----
E
K
-----
L
E
R
----
E
A
K
T
A
V
I
--------------------
V
A
R
------------------------
N
-----------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
56.14
23%
-53
- C3 -
3B8C
2
PMA2_ARATH
A:
[99-657]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
C
L
L
V
I
N
S
T
I
S
F
I
E
E
N
N
A
G
N
A
A
A
A
L
M
A
G
L
A
P
K
T
K
V
L
R
-
D
G
K
W
S
E
Q
E
A
A
I
L
V
P
--
G
D
I
V
S
I
K
L
G
D
I
I
P
A
D
A
R
L
L
E
G
D
P
L
K
---
V
D
Q
S
A
L
T
G
E
S
L
P
V
T
K
-------------
H
P
G
----------
Q
E
----------
V
F
S
G
S
T
C
K
Q
G
E
I
E
A
V
V
I
A
T
G
V
H
T
F
F
G
K
A
A
H
L
V
D
S
T
N
-
Q
V
G
H
F
Q
K
V
L
T
A
I
G
N
F
C
I
C
S
I
A
I
G
M
V
I
E
I
I
V
M
Y
P
I
Q
R
---------
R
-
K
Y
R
D
G
I
D
N
L
L
V
L
L
I
G
G
I
P
I
A
M
P
T
V
L
S
V
T
M
A
I
G
S
H
R
L
S
Q
Q
G
A
I
T
K
R
M
T
A
I
E
E
M
A
G
M
D
V
L
C
S
D
K
T
G
T
L
T
L
N
K
---
L
S
V
D
K
N
---------------------------------------------------
L
V
E
VFCK
G
V
------------------------------
E
--------------------
K
D
-
Q
V
L
L
F
A
A
M
A
S
R
V
----------------
E
N
Q
D
A
I
D
A
A
------------------------------------------
M
V
G
M
L
A
D
P
K
E
A
R
-------
A
G
I
REVHF
L
P
F
N
P
------------------------
V
D
K
R
T
-
A
L
-
T
Y
I
-
D
GS----
G
N
W
H
R
V
S
K
G
A
P
E
Q
I
------
L
E
L
--
A
K
A
---------
S
N
D
L
S
K
K
----
V
L
S
I
I
D
K
Y
A
E
----
R
G
L
R
S
L
A
--------------------
V
A
R
Q
VVPEKTKESPG
A
-----------
P
-----------------------
W
E
F
V
G
L
L
P
L
F
D
P
P
R
H
D
S
A
E
T
I
R
R
A
L
N
L
G
V
N
V
K
M
I
T
G
D
Q
L
A
I
G
K
E
T
G
R
R
L
G
M
-----------------------------------------------------
G
TNMYPSSALLGTHKDANLASIP
V
E
E
L
I
E
K
A
-----------------------
D
G
F
A
G
V
F
P
E
H
K
Y
E
I
V
K
K
L
Q
E
R
K
H
I
V
G
M
T
G
D
G
V
N
D
A
P
A
L
K
K
A
D
I
G
I
A
V
A
-
D
A
T
D
A
A
R
G
A
S
D
I
V
L
T
E
P
G
L
S
V
I
I
S
A
V
L
T
S
R
A
I
F
Q
R
M
K
N
Y
T
I
Y
-----------
A
V
-
S
I
T
I
R
I
V
-----------
F
G
F
M
L
I
A
L
I
W
E
F
D
F
S
A
F
M
V
L
I
I
A
I
L
N
--------------
D
G
T
I
M
T
I
S
K
D
R
V
K
P
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
55.92
42%
-64
- C3 -
3A1E
1
B:
[13-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
---
P
E
V
T
D
L
---------------------------------------------------
V
P
L
----
N
G
------------------------------
D
--------------------
E
R
-
E
L
L
R
L
A
A
I
A
E
-
R
----------------
R
S
E
Q
P
I
A
E
A
------------------------------------------
I
V
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
-----
E
K
V
E
V
------------------------
I
A
G
E
G
V
V
A
-
D
--------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
S
N
--
E
V
E
---------
L
A
---
L
-----
E
K
-----
L
E
R
----
E
A
K
T
A
V
I
--------------------
V
A
R
------------------------
N
-----------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
55.89
43%
-64
- C3 -
3A1C
2
?
A:
[14-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
---
P
E
V
T
D
L
---------------------------------------------------
V
P
L
----
N
G
------------------------------
D
--------------------
E
R
-
E
L
L
R
L
A
A
I
A
E
-
R
----------------
R
S
E
H
P
I
A
E
A
------------------------------------------
I
V
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
-----
E
K
V
E
V
------------------------
I
A
G
E
G
V
V
A
---------------
D
G
I
L
V
G
N
K
R
L
M
------
E
D
F
--
G
V
A
---------
V
S
---
N
E
----
V
E
L
A
L
E
K
L
E
R
----
E
A
K
T
A
V
I
--------------------
V
A
R
------------------------
N
-----------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
-
K
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
55.79
42%
-64
- C3 -
3A1E
2
COPA_ARCFU
A:
[14-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
---
P
E
V
T
D
L
---------------------------------------------------
V
P
L
----
N
G
------------------------------
D
--------------------
E
R
-
E
L
L
R
L
A
A
I
A
E
-
R
----------------
R
S
E
Q
P
I
A
E
A
------------------------------------------
I
V
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
-----
E
K
V
E
V
------------------------
I
A
G
E
G
V
V
A
-
D
--------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
S
N
--
E
V
E
---------
L
A
---
L
-----
E
K
-----
L
E
R
----
E
A
K
T
A
V
I
--------------------
V
A
R
------------------------
N
-----------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
55.63
42%
-64
- C3 -
3A1C
1
?
B:
[14-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
---
P
E
V
T
D
L
---------------------------------------------------
V
P
L
----
N
G
------------------------------
D
--------------------
E
R
-
E
L
L
R
L
A
A
I
A
E
-
R
----------------
R
S
E
H
P
I
A
E
A
------------------------------------------
I
V
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
-----
E
K
V
E
V
------------------------
I
A
G
E
G
V
V
A
-
D
--------------
G
I
L
V
G
N
K
R
L
M
EDFGVA
V
S
N
--
E
V
E
---------
L
A
---
L
-----
E
K
-----
L
E
R
----
E
A
K
T
A
V
I
--------------------
V
A
R
------------------------
N
-----------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
T
M
S
K
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
55.18
42%
-63
- C3 -
3A1C
2
?
A:
[14-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
---
P
E
V
T
D
L
---------------------------------------------------
V
P
L
----
N
G
------------------------------
D
--------------------
E
R
-
E
L
L
R
L
A
A
I
A
E
-
R
----------------
R
S
E
H
P
I
A
E
A
------------------------------------------
I
V
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
-----
E
K
V
E
V
------------------------
I
A
G
E
G
V
V
A
-
D
--------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
S
N
--
E
V
E
---------
L
A
---
L
-----
E
K
-----
L
E
R
----
E
A
K
T
A
V
I
--------------------
V
A
R
------------------------
N
-----------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
55.10
42%
-65
- C3 -
3A1D
2
?
A:
[14-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
L
G
I
L
I
K
N
A
D
A
L
E
V
A
E
K
V
T
A
V
I
F
D
K
T
G
T
L
T
K
G
K
---
P
E
V
T
D
L
---------------------------------------------------
V
P
L
----
N
G
------------------------------
D
--------------------
E
R
-
E
L
L
R
L
A
A
I
A
E
-
R
----------------
R
S
E
H
P
I
A
E
A
------------------------------------------
I
V
K
K
A
L
E
H
G
I
E
L
-------
G
E
P
-----
E
K
V
E
V
------------------------
I
A
G
E
G
V
V
A
-
D
--------------
G
I
L
V
G
N
K
R
L
M
E
D
F
G
V
A
V
S
N
--
E
V
E
---------
L
A
---
L
-----
E
K
-----
L
E
R
----
E
A
K
T
A
V
I
--------------------
V
A
R
------------------------
N
-----------------------
G
R
V
E
G
I
I
A
V
S
D
T
L
K
E
S
A
K
P
A
V
Q
E
L
K
R
M
G
I
K
V
G
M
I
T
G
D
N
W
R
S
A
E
A
I
S
R
E
L
N
L
-----------------------------------------------------
D
-----------------------------------------------------
L
V
I
A
E
V
L
P
H
Q
K
S
E
E
V
K
K
L
Q
A
K
-
E
V
V
A
F
V
G
D
G
I
N
D
A
P
A
L
A
Q
A
D
L
G
I
A
V
G
-
S
G
S
D
V
A
V
E
S
G
D
I
V
L
I
R
D
D
L
R
D
V
V
A
A
I
Q
L
S
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------