@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0432: (2015-11-30 )
MTDHPIKYRLIKQEKHTGARLGEIITPHGTFPTPMFMPVGTQATVKTQSPEELKEMGSGIILSNTYHLWLRPGDELIAKAGGLHKFMNWDQAILTDSGGFQVYSLADSRNITEEGVTFKNHLNGAKMFLSPEKAISIQNNLGSDIMMSFDECPQFYQPYDYVKKSIERTSRWAERGLNAHRRPHDQGLFGIVQGAGFEDLRRQSARDLVSMDFPGYSIGGLAVGETHDEMNAVLDFTVPMLPNDKPRYLMGVGAPDSLIDAVIRGVDMFDCVLPTRIARNGTCMTSQGRLVVKNAKFAEDFTPLDPNCDCYTCKNYTRAYIRHLLKADETFGIRLTSYHNLYFLVNLMKDVRQAIMDDNLLEFRQDFMERYGYGMNNRNF
Atome Classification :
(52 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......----180----.....----..190.......200.......210.......220...--....230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTDHP
I
K
Y
R
L
I
KQEKHTGARLGEIITPHGTFPTP
M
F
M
PVGT
Q
A
T
V
KTQ
S
P
E
E
L
K
E
MGS
G
I
I
LSN
T
Y
H
L
W
LRP
G
D
E
L
I
A
KAGG
L
H
K
FMNW
D
Q
A
ILTDSGG
F
Q
V
Y
S
LADSRNITEEGV
T
F
K
NHLNG
A
K
M
F
LSPE
K
A
I
S
IQNNLG
S
D
I
M
M
S
F
D
EC
P
Q
F
Y
Q
P
Y
D
Y
V
K
K
S
I
E
R
T
S
R
W
A
E
RGLNA----HRR----PHDQG----
L
F
G
I
VQGA
G
F
E
D
L
R
R
Q
S
A
R
D
L
VSMDFPGYSIG
G
L
AVGE--
T
H
D
E
M
N
A
V
L
DFTVPMLPNDKP
R
Y
L
M
GVGA
P
D
S
L
I
D
A
V
I
RG
V
D
M
F
D
C
VL
P
T
R
IARNG
T
C
MTSQ
G
R
L
V
V
KNAKFAEDFTPLDPNC
D
C
Y
T
C
K
N
Y
T
R
A
Y
I
R
H
L
L
KADET
F
G
I
R
L
TSYH
N
L
Y
F
L
V
N
L
M
K
D
V
R
Q
A
IMDD
N
L
L
E
F
R
Q
D
F
M
E
R
YGYGMNNRNF
25
PsiBlast_CBE
97.16
51%
-88
- C6 -
4Q4Q
6
TGT_ZYMMO
A:
[10-381]
--
D
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
60
PsiBlast_CBE
96.94
51%
-87
- C6 -
4Q8V
3
TGT_ZYMMO
A:
[13-383]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
59
PsiBlast_CBE
96.88
51%
-86
- C6 -
4Q8W
6
TGT_ZYMMO
A:
[12-383]
--
D
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
-
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
103
Fugue
96.82
51%
-86
- C6 -
1K4G
2
TGT_ZYMMO
A:
[11-382]
----
R
P
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
R
K
E
Q
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
--GE
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
64
PsiBlast_CBE
96.82
51%
-88
- C6 -
2Z1X
10
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
-------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
88
PsiBlast_CBE
96.75
51%
-83
- C6 -
4Q8P
5
TGT_ZYMMO
A:
[13-383]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
D
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
--
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
17
PsiBlast_PDB
96.68
51%
-84
- C6 -
1S39
2
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
75
PsiBlast_CBE
96.61
51%
-88
- C6 -
4PUL
3
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
N
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
86
PsiBlast_CBE
96.56
51%
-84
- C6 -
1WKE
1
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
A
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
89
PsiBlast_CBE
96.41
51%
-84
- C6 -
4IPP
6
TGT_ZYMMO
A:
[10-381]
--
D
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
D
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
24
PsiBlast_CBE
96.37
51%
-88
- C6 -
4Q4R
5
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
81
PsiBlast_CBE
96.35
51%
-87
- C6 -
4DXX
5
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
--
T
V
M
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
18
PsiBlast_PDB
96.35
51%
-87
- C6 -
2BBF
2
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
--
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
22
PsiBlast_CBE
96.34
51%
-83
- C6 -
4Q8T
6
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
47
PsiBlast_CBE
96.33
51%
-82
- C6 -
3C2Y
7
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
-------
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
5
PsiBlast_PDB
96.30
51%
-85
- C6 -
1K4G
2
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
70
PsiBlast_CBE
96.28
51%
-87
- C6 -
2OKO
17
TGT_ZYMMO
A:
[10-380]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
26
PsiBlast_CBE
96.28
51%
-88
- C6 -
4Q4P
5
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
41
PsiBlast_CBE
96.25
51%
-88
- C6 -
3RR4
4
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
65
PsiBlast_CBE
96.24
51%
-87
- C6 -
2Z1W
11
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
43
PsiBlast_CBE
96.16
51%
-85
- C6 -
3GC5
5
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
31
PsiBlast_CBE
96.10
51%
-86
- C6 -
4PUJ
7
TGT_ZYMMO
A:
[10-381]
--
D
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
--
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
83
PsiBlast_CBE
96.09
51%
-84
- C6 -
4H7Z
5
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
95
PsiBlast_CBE
95.92
51%
-83
- C6 -
4GCX
6
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
----
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
79
PsiBlast_CBE
95.92
51%
-88
- C6 -
4PUM
4
TGT_ZYMMO
A:
[13-383]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
N
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
EN
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
76
PsiBlast_CBE
95.91
51%
-84
- C6 -
4HSH
9
TGT_ZYMMO
A:
[10-380]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
----
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
82
PsiBlast_CBE
95.86
51%
-86
- C6 -
4HVX
5
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
-------
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
80
PsiBlast_CBE
95.81
51%
-88
- C6 -
4Q8Q
2
TGT_ZYMMO
A:
[13-383]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
C
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
72
PsiBlast_CBE
95.62
51%
-89
- C6 -
4Q8O
6
TGT_ZYMMO
A:
[13-383]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
T
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
73
PsiBlast_CBE
95.53
51%
-83
- C6 -
4Q8M
9
TGT_ZYMMO
A:
[13-383]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
T
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
32
PsiBlast_CBE
95.38
51%
-89
- C6 -
4GKT
3
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
--
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
-------
T
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
48
PsiBlast_CBE
95.37
51%
-85
- C6 -
2PWU
5
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
---
K
Q
S
E
E
G
V
T
F
K
S
-------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
-----
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
42
PsiBlast_CBE
95.36
51%
-87
- C6 -
3GE7
4
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
85
PsiBlast_CBE
95.33
51%
-84
- C6 -
4E2V
6
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
------
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
96
PsiBlast_CBE
95.27
51%
-86
- C6 -
2NQZ
8
TGT_ZYMMO
A:
[10-380]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
-------
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
S
G
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
40
PsiBlast_CBE
95.27
51%
-87
- C6 -
3SM0
4
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
---
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
35
PsiBlast_CBE
95.23
51%
-89
- C6 -
4GH3
2
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
--
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
-----
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
93
PsiBlast_CBE
95.14
51%
-83
- C6 -
4HQV
6
TGT_ZYMMO
A:
[10-380]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
46
PsiBlast_CBE
95.09
51%
-90
- C6 -
3EOS
4
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
-----
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
39
PsiBlast_CBE
95.09
51%
-86
- C6 -
3TLL
5
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
91
PsiBlast_CBE
95.03
51%
-86
- C6 -
4L56
8
TGT_ZYMMO
A:
[12-383]
--
D
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
D
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
84
PsiBlast_CBE
94.92
51%
-84
- C6 -
4GD0
6
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
34
PsiBlast_CBE
94.92
51%
-87
- C6 -
4GI4
2
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
36
PsiBlast_CBE
94.84
51%
-87
- C6 -
4GH1
3
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
------
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
77
PsiBlast_CBE
94.79
51%
-84
- C6 -
3BLD
4
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
------
Q
S
E
E
G
V
T
F
K
S
--------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
----------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
44
PsiBlast_CBE
94.58
51%
-85
- C6 -
3GC4
7
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
----------
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
33
PsiBlast_CBE
94.52
51%
-93
- C6 -
4GIY
2
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
45
PsiBlast_CBE
94.49
51%
-88
- C6 -
3EOU
4
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-------
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
37
PsiBlast_CBE
94.17
51%
-95
- C6 -
4FR6
2
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
----
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------
74
PsiBlast_CBE
94.07
51%
-89
- C6 -
1PXG
10
TGT_ZYMMO
A:
[10-380]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
----
F
D
S
----
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
E
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
94
PsiBlast_CBE
93.49
51%
-82
- C6 -
4H6E
8
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
-
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
-------
38
PsiBlast_CBE
93.36
51%
-93
- C6 -
4FR1
2
TGT_ZYMMO
A:
[11-381]
---
R
P
-
R
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
-----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-------
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
K
E
Q
----
A
E
N
A
A
----
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
--
G
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
-
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
--------