@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0440: (2015-11-30 )
MNRKIIGLTLLSLSVLTLTACGNRSDKSANKSDIKVAMVTNQGGVDDKSFNQSAWEGLQKWGKKKGLTKGNGFDYFQSSNESDHANNLDTAASSGYNLIFGIGFGLHDTIEKVSENNKDVKYVIVDDIIKGKENVASVTFADNEAAYLAGVAAAKTTKTKTVGFIGGMEGVVVKRFEAGFKAGVKSIDPAIKVAVSYAGSFTDAAKGKTIAATQYATGVDVIYQAAGGTGAGIFSEAKTENETRKESNKVWVIGVDRDQSQEGNYVSKDGKKANFVLASTIKEVGKSLQSVAELTEKKQYPGGKVTVFGLKDSGVDIKEHQLSSEGSVAVKKAKEDIVSGKIQVPMK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70.......--.-80-........90........100-.......-.-.---110.......120.......---130------........140.......150.....----.---.---160.......170-........180.......190.....-..-----.200........210....--...220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......-..320.--......---..330.......340..---...----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNR
K
I
I
G
L
T
L
L
S
L
S
V
L
T
L
T
ACGNRSDKSANKS
D
I
K
V
A
M
V
TNQGGVDDKSF
N
Q
S
A
W
E
G
L
Q
K
W
G
KKKGLTKGNGFDYFQS--S-NE-SDHANNLDTAASSG
Y
N
L
I
F
---
G
IGFG
L
H
-
D
-
T
---
I
E
K
V
SENNK
D
V
K
Y
V
I
V
D
D
I
I---KG-------KEN
V
A
S
V
T
FADNE
A
A
Y
LA
G
V
AAAKTT----K---
T
---
K
T
V
G
F
IGGME
G
-
V
-
V
V
K
R
F
E
A
G
F
K
A
G
V
K
SIDP
A
I
-
K
V
A
V
S
-YA-----GSF-TDAAKG
K
T
I
A
A
T
QYA--T
G
V
D
V
I
YQAAGGTGAGIFSEAKTENETRKESN
K
V
W
V
I
GVDRDQSQEGNYVSKDGKKA
N
F
V
L
A
S
T
I
K
E
V
G
K
S
L
Q
S
V
A
E
L
T
E
KKQYPG
G
K
V
T
V
F
G
L--KDSGVD
I
-
K
E
H--Q--LSSEG
S
---
V
A
V
K
K
A
K
E
D
IVS
G
K
I
QV---PMK----------------------------------
30
Fugue
95.70
38%
-60
- C3 -
2FQX
1
TMPC_TREPA
A:
[3-318]
-------------------------------
G
D
F
V
V
G
M
V
T
D
S
G
D
I
D
D
K
S
F
N
Q
Q
V
W
E
G
I
S
R
F
A
Q
E
N
N
A
----
K
C
K
Y
V
T
A
--
S
-
T
D
-
A
E
Y
V
P
S
L
S
A
F
A
D
E
N
M
G
L
V
V
---
A
C
G
S
F
L
V
-
E
-
A
---
V
I
E
T
S
A
R
F
P
K
Q
K
F
L
V
I
D
A
V
V
---
Q
D
-------
R
D
N
V
V
S
A
V
F
G
Q
N
E
G
S
F
L
V
G
V
A
A
A
L
K
A
----
K
E
A
G
K
---
S
A
V
G
F
I
V
G
M
E
L
-
G
-
M
M
P
L
F
E
A
G
F
E
A
G
V
K
A
V
D
P
D
I
-
Q
V
V
V
E
-
V
A
-----
N
T
F
-
S
D
P
Q
K
G
Q
A
L
A
A
K
L
Y
D
--
S
G
V
N
V
I
F
Q
V
A
G
G
T
G
N
G
V
I
K
E
A
R
D
R
R
L
N
G
Q
---
D
V
W
V
I
G
V
D
R
D
Q
Y
M
D
G
V
Y
----
D
G
S
K
S
V
V
L
T
S
M
V
K
R
A
D
V
A
A
E
R
I
S
K
M
A
Y
D
G
S
F
P
G
G
Q
S
I
M
F
G
L
--
E
D
K
A
V
G
I
-
P
E
E
NP
N
--
L
S
S
A
V
M
---
E
K
I
R
S
F
E
E
K
I
V
S
K
E
I
V
V
---
P
V
R
SARMMN----------------------------
2
PsiBlast_PDB
95.32
37%
-61
- C3 -
2FQX
1
TMPC_TREPA
A:
[4-312]
--------------------------------
D
F
V
V
G
M
V
T
D
S
G
D
I
D
D
K
S
F
N
Q
Q
V
W
E
G
I
S
R
F
A
Q
E
N
N
A
K
----
C
K
Y
V
T
A
--
S
-
T
D
-
A
E
Y
V
P
S
L
S
A
F
A
D
E
N
M
G
L
V
V
---
A
C
G
S
F
L
V
-
E
-
A
---
V
I
E
T
S
A
R
F
P
K
Q
K
F
L
V
I
D
A
V
V
---
Q
D
-------
R
D
N
V
V
S
A
V
F
G
Q
N
E
G
S
F
L
V
G
V
A
A
A
L
K
A
----
K
---
E
A
GK
S
A
V
G
F
I
V
G
M
E
L
-
G
-
M
M
P
L
F
E
A
G
F
E
A
G
V
K
A
V
D
P
D
I
-
Q
V
V
V
E
-
V
A
-----
N
T
F
-
S
D
P
Q
K
G
Q
A
L
A
A
K
L
Y
D
--
S
G
V
N
V
I
F
Q
V
A
G
G
T
G
N
G
V
I
K
E
A
R
---
D
R
R
L
N
G
Q
D
V
W
V
I
G
V
D
R
D
Q
Y
M
D
G
V
Y
---
D
G
S
K
S
-
V
V
L
T
S
M
V
K
R
A
D
V
A
A
E
R
I
S
K
M
A
Y
D
G
S
F
P
G
G
Q
S
I
M
F
G
L
--
E
D
K
A
V
G
I
-
P
E
E
NP
N
--
L
S
S
A
V
M
---
E
K
I
R
S
F
E
E
K
I
V
S
K
E
I
V
V
---
P
V
R
----------------------------------
3
PsiBlast_PDB
95.29
37%
-61
- C3 -
2FQY
1
TMPC_TREPA
A:
[4-312]
--------------------------------
D
F
V
V
G
M
V
T
D
S
G
D
I
D
D
K
S
F
N
Q
Q
V
W
E
G
I
S
R
F
A
Q
E
N
N
A
K
----
C
K
Y
V
T
A
--
S
-
T
D
-
A
E
Y
V
P
S
L
S
A
F
A
D
E
N
M
G
L
V
V
---
A
C
G
S
F
L
V
-
E
-
A
---
V
I
E
T
S
A
R
F
P
K
Q
K
F
L
V
I
D
A
V
V
---
Q
D
-------
R
D
N
V
V
S
A
V
F
G
Q
N
E
G
S
F
L
V
G
V
A
A
A
L
K
A
----
K
---
E
A
GK
S
A
V
G
F
I
V
G
M
E
L
-
G
-
M
M
P
L
F
E
A
G
F
E
A
G
V
K
A
V
D
P
D
I
-
Q
V
V
V
E
-
V
A
-----
N
T
F
-
S
D
P
Q
K
G
Q
A
L
A
A
K
L
Y
D
--
S
G
V
N
V
I
F
Q
V
A
G
G
T
G
N
G
V
I
K
E
A
R
---
D
R
R
L
N
G
Q
D
V
W
V
I
G
V
D
R
D
Q
Y
M
D
G
V
Y
---
D
G
S
K
S
-
V
V
L
T
S
M
V
K
R
A
D
V
A
A
E
R
I
S
K
M
A
Y
D
G
S
F
P
G
G
Q
S
I
M
F
G
L
--
E
D
K
A
V
G
I
-
P
E
E
NP
N
--
L
S
S
A
V
M
---
E
K
I
R
S
F
E
E
K
I
V
S
K
E
I
V
V
---
P
V
R
----------------------------------
10
HHSearch
95.10
38%
-63
- C3 -
2FQX
1
TMPC_TREPA
A:
[3-311]
-------------------------------
G
D
F
V
V
G
M
V
T
D
S
G
D
I
D
D
K
S
F
N
Q
Q
V
W
E
G
I
S
R
F
A
Q
E
N
N
A
K
----
C
K
Y
V
T
A
--
S
-
T
D
-
A
E
Y
V
P
S
L
S
A
F
A
D
E
N
M
G
L
V
V
---
A
C
G
S
F
L
V
-
E
-
A
---
V
I
E
T
S
A
R
F
P
K
Q
K
F
L
V
I
D
A
V
V
---
Q
D
-------
R
D
N
V
V
S
A
V
F
G
Q
N
E
G
S
F
L
V
G
V
A
A
A
L
K
A
K
E
A
-
G
---
K
---
S
A
V
G
F
I
V
G
M
E
L
-
G
-
M
M
P
L
F
E
A
G
F
E
A
G
V
K
A
V
D
P
D
I
-
Q
V
V
V
E
-
V
A
-----
N
T
F
-
S
D
P
Q
K
G
Q
A
L
A
A
K
L
Y
D
--
S
G
V
N
V
I
F
Q
V
A
G
G
T
G
N
G
V
I
K
E
A
R
D
R
R
L
N
---
G
Q
D
V
W
V
I
G
V
D
R
D
Q
Y
M
D
G
V
Y
D
G
----
S
K
S
V
V
L
T
S
M
V
K
R
A
D
V
A
A
E
R
I
S
K
M
A
Y
D
G
S
F
P
G
G
Q
S
I
M
F
G
L
--
E
D
K
A
V
G
I
-
P
E
E
--
N
PN
L
S
S
A
V
M
---
E
K
I
R
S
F
E
E
K
I
V
S
K
E
I
V
V
---
P
V
R
----------------------------------
1
PsiBlast_PDB
95.09
37%
-63
- C3 -
2FQW
1
TMPC_TREPA
A:
[4-312]
--------------------------------
D
F
V
V
G
M
V
T
D
S
G
D
I
D
D
K
S
F
N
Q
Q
V
W
E
G
I
S
R
F
A
Q
E
N
N
A
K
----
C
K
Y
V
T
A
--
S
-
T
D
-
A
E
Y
V
P
S
L
S
A
F
A
D
E
N
M
G
L
V
V
---
A
C
G
S
F
L
V
-
E
-
A
---
V
I
E
T
S
A
R
F
P
K
Q
K
F
L
V
I
D
A
V
V
---
Q
D
-------
R
D
N
V
V
S
A
V
F
G
Q
N
E
G
S
F
L
V
G
V
A
A
A
L
K
A
----
K
---
E
A
GK
S
A
V
G
F
I
V
G
M
E
L
-
G
-
M
M
P
L
F
E
A
G
F
E
A
G
V
K
A
V
D
P
D
I
-
Q
V
V
V
E
-
V
A
-----
N
T
F
-
S
D
P
Q
K
G
Q
A
L
A
A
K
L
Y
D
--
S
G
V
N
V
I
F
Q
V
A
G
G
T
G
N
G
V
I
K
E
A
R
---
D
R
R
L
N
G
Q
D
V
W
V
I
G
V
D
R
D
Q
Y
M
D
G
V
Y
---
D
G
S
K
S
-
V
V
L
T
S
M
V
K
R
A
D
V
A
A
E
R
I
S
K
M
A
Y
D
G
S
F
P
G
G
Q
S
I
M
F
G
L
--
E
D
K
A
V
G
I
-
P
E
E
NP
N
--
L
S
S
A
V
M
---
E
K
I
R
S
F
E
E
K
I
V
S
K
E
I
V
V
---
P
V
R
----------------------------------
33
Fugue
72.73
22%
-51
- C3 -
3S99
16
PBP_BRUA2
A:
[26-355]
--------------------------------
K
L
K
V
G
F
I
-
Y
I
G
P
P
G
D
F
G
W
T
Y
Q
H
D
Q
A
R
K
E
L
V
E
A
L
G
--
D
K
V
E
T
T
F
L
E
N
--
V
-
A
E
G
A
D
A
E
R
S
I
K
R
I
A
R
A
G
N
K
L
I
F
---
T
T
S
F
G
Y
M
-
D
-
P
---
T
V
K
V
A
K
K
F
P
D
V
K
F
E
H
A
T
G
Y
----
K
T
-------
A
D
N
M
S
A
Y
N
A
R
F
Y
E
G
R
Y
V
Q
G
V
I
A
A
K
M
S
----
K
---
K
---
G
I
A
G
Y
I
G
S
V
P
V
-
P
-
E
V
V
Q
G
I
N
S
F
M
L
G
A
Q
S
V
N
P
D
F
-
R
V
K
V
I
-
W
V
-----
N
S
W
-
F
D
P
G
K
E
A
D
A
A
K
A
L
I
D
--
Q
G
V
D
I
I
T
Q
H
T
D
S
T
--
A
A
I
Q
V
A
H
D
R
G
--------
I
K
A
F
G
Q
A
S
D
M
I
K
F
A
P
---------
D
T
Q
L
T
A
V
V
D
E
W
G
P
Y
Y
I
D
R
A
K
A
V
L
D
G
T
W
K
S
Q
-
N
I
W
W
G
M
--
K
E
G
L
V
K
M
A
P
F
T
--
N
--
M
P
D
D
V
K
---
K
L
A
E
E
T
E
A
R
I
K
S
G
E
L
N
P
FTG
P
I
K
KQDGSEWLKAG
E
K
A
D
D
Q
T
L
L
G
MNFYVAGVDDKLP
12
HHSearch
68.54
20%
-52
- C3 -
3S99
13
PBP_BRUA2
A:
[26-317]
--------------------------------
K
L
K
V
G
F
I
Y
-
I
G
P
P
G
D
F
G
W
T
Y
Q
H
D
Q
A
R
K
E
L
V
E
A
L
G
D
K
--
V
E
T
T
F
L
E
N
--
V
A
E
G
-
A
D
A
E
R
S
I
K
R
I
A
R
A
G
N
K
L
I
F
---
T
T
S
F
G
Y
M
-
D
-
P
---
T
V
K
V
A
K
K
F
P
D
V
K
F
E
H
A
T
G
Y
K
---
T
--------
A
D
N
M
S
A
Y
N
A
R
F
Y
E
G
R
Y
V
Q
G
V
I
A
A
K
M
S
----
K
---
K
---
G
I
A
G
Y
I
G
S
V
P
V
-
P
-
E
V
V
Q
G
I
N
S
F
M
L
G
A
Q
S
V
N
P
D
F
-
R
V
K
V
I
-
W
V
-----
N
S
W
-
F
D
P
G
K
E
A
D
A
A
K
A
L
I
D
--
Q
G
V
D
I
I
T
Q
H
T
D
S
--
T
A
A
I
Q
V
A
H
D
R
G
--------
I
K
A
F
G
Q
A
S
D
M
I
K
F
---------
A
P
D
T
Q
L
T
A
V
V
D
E
W
G
P
Y
Y
I
D
R
A
K
A
V
L
D
G
T
W
K
S
Q
-
N
I
W
W
G
M
--
K
E
G
L
V
K
M
-
A
P
F
--
T
N-
M
P
D
D
V
K
---
K
L
A
E
E
T
E
A
R
I
K
S
G
E
L
N
P
---
F
T
G
----------------------------------
26
HHSearch
59.71
17%
-69
- C3 -
1GUD
4
ALSB_ECOLI
A:
[2-263]
---------------------------------
A
E
Y
A
V
V
L
-
K
-
T
L
-
S
N
P
F
W
V
D
M
K
K
G
I
E
D
E
A
K
T
L
G
V
S
----
V
D
I
F
A
S
PS
E
G
D
F
-
Q
S
Q
L
Q
L
F
E
D
L
S
N
K
N
Y
K
G
I
A
---
F
A
P
L
S
S
V
-
N
-
L
V
M
P
V
A
R
A
--
W
K
K
G
I
Y
L
V
N
L
D
E
K
I
---
D
M
D
N
L
K
K
A
G
G
N
V
E
A
F
V
T
T
D
N
V
A
V
G
A
K
G
A
S
F
I
I
D
K
L
----
G
---
A
EG-
G
E
V
A
I
I
E
G
K
A
G
N
A
-
S
G
E
A
R
R
N
G
A
T
E
A
F
K
K
A
-
S
Q
I
-
K
L
V
A
S
-
Q
P
-----
A
D
W
-
D
-
R
I
K
A
L
D
V
A
T
N
V
L
Q
R
N
P
N
I
K
A
I
Y
C
A
N
D
T
M
A
M
G
V
A
Q
A
V
A
N
A
G
K
----
T
G
K
V
L
V
V
G
T
D
G
I
P
E
A
R
K
M
V
------
E
A
G
Q
M
T
A
T
V
A
Q
N
P
A
D
I
G
A
T
G
L
K
L
M
V
D
A
E
K
S
G
K
V
I
P
L
D
K
A
--
P
E
F
K
L
V
D
-
S
I
L
--
V
--
T
Q
----------------------------------------------------------------
15
HHSearch
59.62
14%
-56
- C3 -
2O20
3
?
A:
[62-308]
-------------------------------
R
T
T
T
V
G
V
I
L
-
P
-
T
I
-
T
S
T
Y
F
A
A
I
T
R
G
V
D
D
I
A
S
M
Y
K
Y
N
----
M
I
L
A
N
S
--
D
N
D
V
-
E
K
E
E
K
V
L
E
T
F
L
S
K
Q
V
D
G
I
V
---
Y
M
G
S
S
L
D
-
E
K
I
---
R
T
S
L
--
K
N
S
R
T
P
V
V
L
V
G
T
I
D
---
G
--------
D
K
E
I
P
S
V
N
I
D
Y
H
L
A
A
Y
Q
S
T
K
K
L
I
D
S
G
--------
N
---
K
K
I
A
Y
I
M
G
S
L
K
D
V
-
E
N
T
E
R
M
V
G
Y
Q
E
A
L
L
E
A
N
I
E
F
-
D
E
N
L
V
-
F
E
-----
G
N
Y
--
S
Y
E
Q
G
K
A
L
A
E
R
L
L
E
--
R
G
A
T
S
A
V
V
S
H
D
T
V
A
V
G
L
L
S
A
M
M
D
K
G
V
K
--
V
P
E
D
F
E
I
I
S
G
A
N
S
P
I
T
Q
Y
---------
T
Y
P
T
L
T
S
V
N
Q
P
L
Y
D
L
G
A
V
A
M
R
L
L
T
K
L
M
L
K
E
D
V
E
Q
N
Q
L
V
--
L
D
H
E
I
F
S
-
R
R
S
--
T
--
K
-----------------------------------------------------------------
23
HHSearch
58.78
17%
-56
- C3 -
3CLK
1
?
A:
[8-254]
--------------------------------
S
N
V
I
A
A
V
V
-
S
-
S
-
V
R
T
N
F
A
Q
Q
I
L
D
G
I
Q
E
E
A
H
K
N
G
Y
N
----
L
I
I
V
Y
------------
H
A
L
L
T
A
I
E
R
P
V
M
G
I
L
---
L
L
S
I
A
-----
N
---
L
Q
L
L
--
Q
S
S
--
P
Y
C
F
L
S
M
G
--------------
D
D
R
P
F
I
S
S
D
D
E
D
I
G
Y
Q
A
T
N
L
L
I
N
E
G
--------
H
---
R
Q
I
G
I
A
G
I
D
Q
Y
P
Y
-
T
G
R
K
R
L
A
G
Y
K
K
A
L
K
E
A
N
I
A
I
-
N
Q
E
W
I
-
K
P
-----
G
D
Y
-
S
-
Y
T
S
G
E
Q
A
M
K
A
F
G
K
N-
T
D
L
T
G
I
I
A
A
S
D
M
T
A
I
G
I
L
N
Q
A
S
S
F
G
I
E
--
V
P
K
D
L
S
I
V
S
I
D
G
T
E
M
C
K
I
---------
T
R
P
Q
L
T
S
I
S
Q
D
F
F
Q
M
G
V
T
G
V
Q
Q
I
H
Q
S
V
K
I
V
S
Q
Q
F
I
P
V
N
--
P
V
I
R
K
S
T
-
A
R
L
-----------------------------------------------------------------------
28
HHSearch
58.29
17%
-45
* C3 *
2QU7
1
?
A:
[7-255]
-------------------------------
R
S
N
I
I
A
F
I
V
-
P
D
---
Q
N
P
F
F
T
E
V
L
T
E
I
S
H
E
C
Q
K
H
H
L
H
----
V
A
V
A
S
S
--
E
E
N
E
-
D
K
Q
Q
D
L
I
E
T
F
V
S
Q
N
V
S
A
I
I
---
L
V
P
V
K
S
K
-
F
-----
Q
M
K
R
--
E
W
L
K
I
P
I
M
T
L
D
R
E
L
---
E
--------
S
T
S
L
P
S
I
T
V
D
N
E
E
A
A
Y
I
A
T
K
R
V
L
E
S
T
--------
C
---
K
E
V
G
L
L
L
A
N
P
N
I
S
-
T
T
I
G
R
K
N
G
Y
N
K
A
I
S
E
F
D
L
N
V
-
N
P
S
L
I
H
Y
S
DQQLG
T
N
A
--
Q
I
Y
S
G
Y
E
A
T
K
T
L
L
S
--
K
G
I
K
G
I
V
A
T
N
H
L
L
L
L
G
A
L
Q
A
I
K
E
S
E
K
E
--
I
K
K
D
V
I
I
V
G
F
D
D
S
Y
W
N
E
I
---------
Y
T
P
K
L
T
V
I
S
Q
P
V
K
E
M
G
Q
V
A
A
K
M
I
Y
K
L
I
K
G
K
D
V
T
S
I
K
L
S
--
T
K
L
I
I
R
E
-
S
C
S
--
F
--
N
-----------------------------------------------------------------
5
PsiBlast_PDB
55.71
30%
-77
- C3 -
3S99
8
PBP_BRUA2
A:
[73-221]
-------------------------------------------------------------------------------------
A
D
A
E
R
S
I
K
R
I
A
R
A
G
N
K
L
I
F
---
T
T
S
F
G
Y
M
-
D
-
P
---
T
V
K
V
A
K
K
F
P
D
V
K
F
E
H
A
T
G
Y
----
K
T
-------
A
D
N
M
S
A
Y
N
A
R
F
Y
E
G
R
Y
V
Q
G
V
I
A
A
K
M
S
----
K
---
K
---
G
I
A
G
Y
I
G
S
V
P
V
-
P
-
E
V
V
Q
G
I
N
S
F
M
L
G
A
Q
S
V
N
P
D
F
-
R
V
K
V
I
-
W
V
-----
N
S
W
-
F
D
P
G
K
E
A
D
A
A
K
A
L
I
D
--
Q
G
V
D
I
I
T
Q
H
T
D
S
T
A
A
I
Q
V
A
H
D
R
G
I
K
A
F
G
Q
A
S
D
M
I
K
F
A
P
D
T
Q
L
T
A
V
V
D
E
W
G
P
Y
Y
I
D
R
A
K
A
V
L
D
G
T
W
K
S
Q
N
I
W
W
G
M
K
E
G
L
V
K
M
A
P
F
T
N
M
P
D
D
V
K
K
L
--
A
E
E
T
E
A
R
-
I
K
S
--
G
--
E
L
N
P
F
T
---
G
P
I
K
K
Q
D
G
S
E
W
L
K
A
G
E
K
---
A
D
D
----------------------------------
22
HHSearch
55.69
14%
-62
- C3 -
3BIL
-
?
A:
[67-308]
----------------------------------
T
I
G
V
I
V
-
P
-
S
L
-
I
N
H
Y
F
A
A
M
V
T
E
I
Q
S
T
A
S
K
A
G
L
A
----
T
I
I
T
N
S
--
N
E
D
A
-
T
T
M
S
G
S
L
E
F
L
T
S
H
G
V
D
G
I
I
---
C
V
P
N
E
E
C
-
A
N
Q
---
L
E
D
L
--
Q
K
Q
-
M
P
V
V
L
V
D
R
E
L
---
P
G
-------
D
-
T
I
P
T
A
T
S
N
P
Q
P
G
I
A
A
A
V
E
L
L
A
H
N
N
--------
A
---
L
P
I
G
Y
L
S
G
P
M
D
T
S
-
T
G
R
E
R
L
E
D
F
K
A
A
C
A
N
S
K
I
G
E
-
Q
L
--
V
-
F
L
-----
G
G
Y
-
E
-
Q
S
V
G
F
E
G
A
T
K
L
L
D
--
Q
G
A
K
T
L
F
A
G
D
S
M
M
T
I
G
V
I
E
A
C
H
K
A
G
L
V
--
I
G
K
D
V
S
V
I
G
F
D
T
H
P
L
F
A
L
---------
Q
P
H
P
L
T
V
I
D
Q
N
V
E
Q
L
A
Q
R
A
V
S
I
L
T
E
L
T
T
I
P
T
A
L
I
H
R
E
S
--
I
I
N
S
------------------------------------------------------------------------------
14
HHSearch
55.57
13%
-51
- C3 -
1QPZ
1
PURR_ECOLI
A:
[56-306]
------------------------------
N
H
T
K
S
I
G
L
L
A
-
T
-
S
S
-
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
----
L
I
L
G
N
A
--
W
N
N
L
-
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
---
V
M
C
S
E
Y
P
-
E
-
P
L
--
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
---
A
K
-------
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
--------
H
---
R
E
I
G
V
I
P
G
P
L
E
R
N
-
T
G
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
-
P
E
S
W
I
-
V
Q
-----
G
D
F
--
E
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
QP
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
--
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
---------
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
--
V
H
P
R
L
I
E
-
R
R
S
--
V
--
A
D
G
P
F
R
---
D
Y
R
------------------------------------------------------
19
HHSearch
54.91
13%
-50
- C3 -
1DBQ
1
PURR_ECOLI
A:
[8-255]
---------------------------------
K
S
I
G
L
L
A
-
T
S
--
S
E
A
A
Y
F
A
E
I
I
E
A
V
E
K
N
C
F
Q
K
G
Y
T
----
L
I
L
G
N
A
--
W
N
N
L
-
E
K
Q
R
A
Y
L
S
M
M
A
Q
K
R
V
D
G
L
L
---
V
M
C
S
E
Y
P
-
E
-
P
L
--
L
A
M
L
E
-
E
Y
R
H
I
P
M
V
V
M
D
W
G
E
---
A
K
-------
A
D
F
T
D
A
V
I
D
N
A
F
E
G
G
Y
M
A
G
R
Y
L
I
E
R
G
--------
H
---
R
E
I
G
V
I
P
G
P
-------
A
G
R
L
A
G
F
M
K
A
M
E
E
A
M
I
K
V
-
P
E
S
W
I
-
V
Q
-----
G
D
F
-
E
-
P
E
S
G
Y
R
A
M
Q
Q
I
L
S
QP
H
R
P
T
A
V
F
C
G
G
D
I
M
A
M
G
A
L
C
A
A
D
E
M
G
L
R
--
V
P
Q
D
V
S
L
I
G
Y
D
N
V
R
N
A
R
Y
---------
F
T
P
A
L
T
T
I
H
Q
P
K
D
S
L
G
E
T
A
F
N
M
L
L
D
R
I
V
N
K
R
E
E
P
Q
S
I
E
--
V
H
P
R
L
I
E
-
R
R
S
--
V
--
A
D
G
P
F
R
---
D
Y
R
R
-----------------------------------------------------
25
HHSearch
54.53
13%
-51
- C3 -
3DBI
2
ASCG_ECOLI
A:
[60-310]
-------------------------------
S
T
Q
T
L
G
L
V
V
-
T
N
T
L
Y
H
G
I
Y
F
S
E
L
L
F
H
A
A
R
M
A
E
E
K
G
R
Q
----
L
L
L
A
D
G
--
K
H
S
A
-
E
E
E
R
Q
A
I
Q
Y
L
L
D
L
R
C
D
A
I
M
---
I
Y
P
R
F
L
S
V
D
-
E
---
I
D
D
I
I
-
D
A
H
S
Q
P
I
M
V
L
N
R
R
L
---
R
--------
K
N
S
S
H
S
V
W
C
D
H
K
Q
T
S
F
N
A
V
A
E
L
I
N
A
G
--------
H
---
Q
E
I
A
F
L
T
G
S
M
D
S
P
-
T
S
I
E
R
L
A
G
Y
K
D
A
L
A
Q
H
G
I
A
L
-
N
E
K
L
I
-
A
N
-----
G
K
W
-
T
-
P
A
S
G
A
E
G
V
E
M
L
L
E
R
G
A
K
F
S
A
L
V
A
S
N
D
D
M
A
I
G
A
M
K
A
L
H
E
R
G
V
A
--
V
P
E
Q
V
S
V
I
G
F
D
D
I
A
I
A
P
Y
---------
T
V
P
A
L
S
S
V
K
I
P
V
T
E
M
I
Q
E
I
I
G
R
L
I
F
M
L
D
G
G
D
F
S
P
P
K
T
F
--
S
G
K
L
I
R
R
-
D
S
L
--
I
--
A
P
S
---------------------------------------------------------------
17
HHSearch
54.11
15%
-49
- C3 -
2FEP
2
CCPA_BACSU
A:
[16-264]
--------------------------------
T
T
T
V
G
V
I
I
-
P
-
D
-
I
S
S
I
F
Y
S
E
L
A
R
G
I
E
D
I
A
T
M
Y
K
Y
N
----
I
I
L
S
N
S
--
D
Q
N
M
-
E
K
E
L
H
L
L
N
T
M
L
G
K
Q
V
D
G
I
V
---
F
M
G
G
N
I
T
-
D
E
H
---
V
A
E
F
--
K
R
S
P
V
P
I
V
L
A
A
S
V
E
---
E
--------
Q
E
E
T
P
S
V
A
I
D
Y
E
Q
A
I
Y
D
A
V
K
L
L
V
D
K
G
--------
H
---
T
D
I
A
F
V
S
G
P
M
A
E
P
I
N
R
S
K
K
L
Q
G
Y
K
R
A
L
E
E
A
N
L
P
F
-
N
E
Q
F
V
-
A
E
-----
G
D
Y
-
T
-
Y
D
S
G
L
E
A
L
Q
H
L
M
S
LD
K
K
P
T
A
I
L
S
A
T
D
E
M
A
L
G
I
I
H
A
A
Q
D
Q
G
L
S
--
I
P
E
D
L
D
I
I
G
F
D
N
T
R
L
S
L
M
---------
V
R
P
Q
L
S
T
V
V
Q
P
T
Y
D
I
G
A
V
A
M
R
L
L
T
K
L
M
N
K
E
P
V
E
E
H
I
V
E
--
L
P
H
R
I
E
L
-
R
K
S
--
T
--
K
-----------------------------------------------------------------
7
PsiBlast_PDB
53.62
25%
-83
- C3 -
4P98
16
?
A:
[72-215]
-----------------------------------------------------------------------------------------------
A
A
R
G
F
D
L
V
V
---
G
H
G
I
D
V
S
-
E
-
P
---
I
L
R
V
A
T
E
F
P
D
V
H
F
S
A
S
G
D
A
T
LAE
R
L
-------
P
P
N
V
D
G
W
T
Y
D
F
G
Q
L
G
Y
L
D
G
F
V
A
G
S
L
R
----
G
---
V
---
E
K
V
G
A
V
G
G
P
Q
L
-
P
-
F
V
L
A
T
H
K
G
I
R
A
G
L
K
A
A
N
P
R
A
-
S
Y
E
E
T
-
Y
T
-----
G
R
F
-
Y
D
L
Q
K
E
Q
E
A
A
R
G
L
L
D
--
K
G
A
Q
L
L
V
A
T
D
D
G
R
G
L
G
Q
A
A
V
A
G
D
V
P
T
I
G
V
S
A
A
A
G
A
D
I
K
A
V
N
I
T
T
A
L
D
L
L
P
T
Y
Q
S
Y
L
E
Q
I
R
A
G
T
F
G
R
R
F
D
V
L
A
L
G
N
R
G
I
V
L
T
P
I
T
A
V
G
D
V
V
P
D
D
L
--
Q
A
R
V
D
A
L
-
S
E
R
--
L
--
A
S
G
E
L
R
---
L
P
N
F
F
E
---------------------------------------------------
24
HHSearch
52.59
11%
-63
- C3 -
3H5O
2
?
A:
[63-307]
---------------------------------
R
T
V
L
V
L
I
-
P
-
S
L
-
A
N
T
V
F
L
E
T
L
T
G
I
E
T
V
L
D
A
A
G
Y
Q
----
M
L
I
G
N
S
--
H
Y
D
A
-
G
Q
E
L
Q
L
L
R
A
Y
L
Q
H
R
P
D
G
V
L
---
I
T
G
L
S
H
A
-
E
-
P
F
--
E
R
I
L
--
S
Q
H
A
L
P
V
V
Y
M
M
D
L
A
------------
D
D
G
R
C
C
V
G
F
S
Q
E
D
A
G
A
A
I
T
R
H
L
L
S
R
G
--------
K
---
R
R
I
G
F
L
G
A
Q
L
D
-
E
-
R
V
M
K
R
L
D
G
Y
R
A
A
L
D
A
A
D
C
R
D
A
G
L
E
W
L
-
D
P
-----
Q
P
S
--
S
M
Q
M
G
A
D
M
L
D
R
A
L
A
E
R
P
D
C
D
A
L
F
C
C
N
D
D
L
A
I
G
A
L
A
R
S
Q
Q
L
G
I
A
--
V
P
E
R
L
A
I
A
G
F
N
D
L
Q
P
A
A
W
---------
C
T
P
P
L
T
T
V
A
T
P
R
R
D
I
G
V
H
A
A
K
A
L
L
Q
L
I
D
G
E
E
P
A
S
R
R
A
D
--
L
G
F
R
L
M
L
-
R
R
S
--
S
--
E
G
----------------------------------------------------------------
34
Fugue
52.38
13%
-29
- C3 -
1TJY
1
LSRB_SALTY
A:
[1-316]
G
S
A
E
R
I
A
F
I
P
K
L
V
G
V
G
F
F
T
S
G
G
N
G
A
Q
E
A
G
K
A
L
G
I
D
V
T
Y
D
G
P
T
-----------------------------------
E
--
P
-
S
V
-
S
G
Q
V
Q
L
V
N
N
F
V
N
Q
G
Y
D
A
I
I
V
SA
V
S
P
D
G
L
C
-
P
-
A
---
L
K
R
A
M
Q
R
G
--
V
K
I
L
T
W
D
S
D
T
---
K
P
-------
E
C
R
S
Y
Y
I
N
Q
G
T
P
K
Q
L
G
S
M
L
V
E
M
A
A
H
Q
V
DKE
K
---
A
---
K
V
A
F
F
Y
S
S
P
T
V
-
T
-
D
Q
N
Q
W
V
K
E
A
K
A
K
I
S
Q
E
H
P
G
W
-
E
I
V
T
T
-
Q
F
-----
G
Y
N
D
A
T
K
S
L
Q
T
A
E
G
I
I
K
A
Y
--
P
D
L
D
A
I
I
A
P
D
A
N
A
L
P
A
A
A
Q
A
A
E
N
L
K
-----
R
N
N
L
A
I
V
G
F
S
--
T
P
N
V
M
R
P
Y
V
Q
R
G
T
V
K
E
F
G
L
W
D
V
V
Q
Q
G
K
I
S
V
Y
V
A
N
A
L
L
K
N
M
P
M
N
V
G
D
S
L
D
I
P
G
IG
K
V
T
V
S
P
N
-
S
E
Q
--
G
--
Y
H
Y
E
A
K
G
N
G
I
V
L
L
P
E
R
V
I
F
N
K
D
N
I
D
K
---
Y
D
F
----------------------------------