@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0442: (2015-12-01 )
MTKQKIAVLGPGSWGTALAQVLNDNGHEVRLWGNVVEQIEEINTSHTNQRYFKDITLDSKIKAYTNLEEAINNVDSILFVVPTKVTRLVAKQVANLLKHKVVIMHASKGLEPGTHERLSTILEEEISEQYRSDIVVVSGPSHAEEAIVRDITLITAASKDIGAAKYVQKLFSNHYFRLYTNTDVVGVETAGALKNIIAVGAGALHGLGYGDNAKAAIITRGLAEITRLGVQLGADPLTFSGLSGVGDLIVTGTSVHSRNWRAGDALGRGEKLEDIEKNMGMVIEGISTTKVAYEIAQNLNVYMPITEAIYKSIYEGANIKDSILDMMSNEFRSENEWH
Atome Classification :
(20 SA)
----.........10........20..-------..--...-------.30.......-------.40----------........50........60........70........80......-..90.-----....----.-..----100.......110.--..--....120....-...130.......140.......150.....---..160..------.....170--.--......180.......190.......200.......210.......220...---....230---...---..---..240.......250.......260.....-.-.270....----...--280.......290.......300-.--.......310.......320.......330......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MT
K
Q
K
I
A
V
LGPG
S
W
G
T
A
L
A
Q
V
L
N-------DN--G
H
E
-------
V
R
L
W
G
N
V
V
E
Q
-------
I
E
E
----------
I
NTSHTN
Q
R
Y
F
K
DITLD
S
K
I
K
A
YT
N
L
E
E
A
INNV
D
S
I
L
F
VV
P
T
K
V
T
R
-
L
V
A
K
Q
-----
V
A
N
L
----
L
-KH----
K
V
V
I
M
HASKGLEPG--
T
H
--
E
R
L
S
T
I
L
E
E
E
I
-
S
E
Q
Y
RS
D
I
V
V
VSGPS
H
A
E
E
A
I
V
R
D
I
T
L
I
T
AA---SKDI
G
A
A
------
K
Y
V
Q
K
L
F
S--N--
H
Y
F
R
L
Y
TNT
D
V
V
G
V
E
T
A
G
A
L
K
N
I
I
A
V
G
A
G
A
L
HGLGYGDNA
K
A
A
I
I
T
R
G
L
A
E
I
---
T
R
L
G
V
QL---GAD---PL---TFSGLSGVG
D
L
I
V
TGTSVHSRNWRAGDALG-R-G
E
K
L
E
D
I
E
----
K
NM--
G
M
V
I
EGIST
T
K
V
A
Y
E
I
A
QNL
N
V
--
Y
--MP
I
T
E
A
I
Y
K
S
I
YEGAN
I
K
D
S
I
L
D
M
M
S
N
E
FRSENEWH---
59
Fugue
92.38
35%
-87
- C1 -
1EVY
1
GPDA_LEIME
A:
[9-357]
KD
E
L
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
--
C
R
E
-------
V
C
V
W
H
M
N
E
E
E
-------
V
R
L
----------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
-
G
F
F
E
K
SG
G
N
L
I
A
Y
A
----
K
-
E
K
----
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
--
T
L
--
K
F
P
A
E
I
I
G
E
F
L
-
P
S
P
L
---
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
V
A
------
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
A
-----
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
LFK
2
PsiBlast_PDB
92.32
35%
-88
- C1 -
1EVY
1
GPDA_LEIME
A:
[17-350]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
--
C
R
E
-------
V
C
V
W
H
M
N
E
E
E
-------
V
R
L
----------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
-----
G
G
N
L
----
I
-
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
--
T
L
--
K
F
P
A
E
I
I
G
E
F
L
-
P
S
P
L
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
V
A
------
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
---
39
HHSearch
92.07
35%
-86
- C1 -
1EVY
1
GPDA_LEIME
A:
[13-350]
----
L
Y
L
N
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
--
C
R
E
-------
V
C
V
W
H
M
N
E
E
E
-------
V
R
L
----------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
-
G
F
F
E
K
-----
S
G
G
N
L
I
A
Y
A
K
E
K
----
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
--
T
L
--
K
F
P
A
E
I
I
G
E
F
L
-
P
S
P
---
L
L
S
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
V
A
------
R
R
L
Q
R
I
M
S
--
T
GD
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
---
7
PsiBlast_PDB
92.05
35%
-81
- C1 -
1N1E
1
GPDA_LEIME
A:
[17-350]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
--
C
R
E
-------
V
C
V
W
H
M
N
E
E
E
-------
V
R
L
----------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
-----
G
G
N
L
----
I
-
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
--
T
L
--
K
F
P
A
E
I
I
G
E
F
L
-
P
S
P
L
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
V
A
------
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
T
S
--
K
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
---
21
PsiBlast_CBE
91.98
35%
-82
- C1 -
1N1E
1
GPDA_LEIME
B:
[17-350]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
--
C
R
E
-------
V
C
V
W
H
M
N
E
E
E
-------
V
R
L
----------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
-----
G
G
N
L
----
I
-
A
Y
AKEK
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
--
T
L
--
K
F
P
A
E
I
I
G
E
F
L
-
P
S
P
L
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
V
A
------
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
T
S
--
K
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
---
41
HHSearch
91.77
35%
-81
- C1 -
3K96
1
GPDA_COXBU
A:
[28-352]
-----
F
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
K
--
G
Q
K
-------
V
R
L
W
S
Y
E
S
D
H
-------
V
D
E
----------
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
-
E
V
I
T
R
-----
M
K
P
L
----
I
-
D
A
----
K
T
R
I
A
W
G
T
K
G
L
A
K
G
--
S
---
R
L
L
H
E
V
V
A
T
E
L
-
G
Q
-
V
--
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
---
S
N
N
S
Q
F
S
------
K
D
L
I
E
R
L
H
--
G
--
Q
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
---
G
G
K
---
Q
E
---
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
-
E
-
G
V
D
K
K
E
A
Q
----
Q
A
I
--
G
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
I
--
E
--
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
S
-----------
6
PsiBlast_PDB
91.77
35%
-84
- C1 -
1M67
2
GPDA_LEIME
A:
[17-350]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
--
C
R
E
-------
V
C
V
W
H
M
N
E
E
E
-------
V
R
L
----------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
-----
G
G
N
L
----
I
-
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
--
T
L
--
K
F
P
A
E
I
I
G
E
F
L
-
P
S
P
L
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
V
A
------
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
---
5
PsiBlast_PDB
91.52
35%
-82
- C1 -
1M66
2
GPDA_LEIME
A:
[17-350]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
--
C
R
E
-------
V
C
V
W
H
M
N
E
E
E
-------
V
R
L
----------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
-----
G
G
N
L
----
I
-
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
--
T
L
--
K
F
P
A
E
I
I
G
E
F
L
-
P
S
P
L
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
V
A
------
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
---
4
PsiBlast_PDB
91.00
35%
-86
- C1 -
1JDJ
2
GPDA_LEIME
A:
[17-350]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
--
C
R
E
-------
V
C
V
W
H
M
N
E
E
E
-------
V
R
L
----------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
-----
G
G
N
L
----
I
-
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
--
T
L
--
K
F
P
A
E
I
I
G
E
F
L
-
P
S
P
L
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
V
A
------
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
---
3
PsiBlast_PDB
90.99
35%
-84
- C1 -
1EVZ
2
GPDA_LEIME
A:
[17-350]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
--
C
R
E
-------
V
C
V
W
H
M
N
E
E
E
-------
V
R
L
----------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
-----
G
G
N
L
----
I
-
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
--
T
L
--
K
F
P
A
E
I
I
G
E
F
L
-
P
S
P
L
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
V
A
------
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
---
8
PsiBlast_PDB
90.61
35%
-82
- C1 -
1N1G
3
GPDA_LEIME
A:
[17-350]
--------
K
A
V
V
F
G
S
G
A
F
G
T
A
L
A
M
V
L
S
-------
K
K
--
C
R
E
-------
V
C
V
W
H
M
N
E
E
E
-------
V
R
L
----------
V
N
E
K
R
E
N
V
L
F
L
K
G
V
Q
L
A
S
N
I
T
F
T
S
D
V
E
K
A
Y
N
G
A
E
I
I
L
F
V
I
P
T
Q
F
L
R
G
F
F
E
K
S
-----
G
G
N
L
----
I
-
A
Y
A
K
E
K
Q
V
P
V
L
V
C
T
K
G
I
E
R
S
--
T
L
--
K
F
P
A
E
I
I
G
E
F
L
-
P
S
P
L
L
S
---
V
L
A
G
P
S
F
A
I
E
V
A
T
G
V
F
T
C
V
S
I
A
---
S
A
D
I
N
V
A
------
R
R
L
Q
R
I
M
S
TG
D
--
R
S
F
V
C
W
A
T
T
D
T
V
G
C
E
V
A
S
A
V
K
N
V
L
A
I
G
S
G
V
A
N
G
L
G
M
G
L
N
A
R
A
A
L
I
M
R
G
L
L
E
I
---
R
D
L
T
A
A
L
---
G
G
D
---
G
S
---
A
V
F
G
L
A
G
L
G
D
L
Q
L
T
C
S
S
E
L
S
R
N
F
T
V
G
K
K
L
G
-
K
-
G
L
P
I
E
E
I
Q
----
R
-----
A
V
A
E
G
V
A
T
A
D
P
L
M
R
L
A
K
Q
L
K
V
--
K
--
M
P
L
C
H
Q
I
Y
E
I
V
Y
K
K
K
N
P
R
D
A
L
A
D
L
L
S
C
G
L
Q
D
E
G
L
P
P
---
9
PsiBlast_PDB
90.15
35%
-78
- C1 -
3K96
1
GPDA_COXBU
A:
[29-352]
------
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
K
--
G
Q
K
-------
V
R
L
W
S
Y
E
S
D
H
-------
V
D
E
----------
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
-
E
V
I
T
R
-----
M
K
P
L
----
I
-
D
A
----
K
T
R
I
A
W
G
T
K
G
L
A
K
G
---------
S
R
L
L
H
E
V
V
A
T
E
L
G
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
---
S
N
N
S
Q
F
S
------
K
D
L
I
E
R
L
H
--
G
--
Q
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
---
G
G
K
---
Q
E
---
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
-
E
-
G
V
D
K
K
E
A
Q
----
Q
A
I
--
G
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
I
--
E
--
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
S
-----------
22
PsiBlast_CBE
89.91
35%
-79
- C1 -
3K96
2
GPDA_COXBU
B:
[29-351]
------
K
H
P
I
A
I
L
G
A
G
S
W
G
T
A
L
A
L
V
L
A
-------
R
K
--
G
Q
K
-------
V
R
L
W
S
Y
E
S
D
H
-------
V
D
E
----------
M
Q
A
E
G
V
N
N
R
Y
L
P
N
Y
P
F
P
E
T
L
K
A
Y
C
D
L
K
A
S
L
E
G
V
T
D
I
L
I
V
V
P
S
F
A
F
H
-
E
V
I
T
R
-----
M
K
P
L
----
I
-
D
A
----
K
T
R
I
A
W
G
T
K
G
L
A
K
G
---------
S
R
L
L
H
E
V
V
A
T
E
L
G
Q
V
P
M
A
V
I
S
G
P
S
L
A
T
E
V
A
A
N
L
P
T
A
V
S
L
A
---
S
N
N
S
Q
F
S
------
K
D
L
I
E
R
L
H
--
G
--
Q
R
F
R
V
Y
K
N
D
D
M
I
G
V
E
L
C
G
S
V
K
N
I
L
A
I
A
T
G
I
S
D
G
L
K
L
G
S
N
A
R
A
A
L
I
T
R
G
L
T
E
M
---
G
R
L
V
S
V
F
---
G
G
K
---
Q
E
---
T
L
T
G
L
A
G
L
G
D
L
V
L
T
C
T
D
N
Q
S
R
N
R
R
F
G
L
A
L
G
-
E
-
G
V
D
K
K
E
A
Q
----
Q
A
I
--
G
Q
A
I
E
G
L
Y
N
T
D
Q
V
H
A
L
A
Q
K
H
A
I
--
E
--
M
P
L
T
F
Q
V
H
R
I
L
H
E
D
L
D
P
Q
Q
A
V
Q
E
L
L
E
R
------------
1
PsiBlast_PDB
89.80
40%
-76
- C1 -
1Z82
7
?
A:
[16-325]
--------
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
-------
E
N
--
G
E
E
-------
V
I
L
W
A
R
R
K
E
I
-------
V
D
L
----------
I
N
V
S
H
T
S
P
-
Y
V
E
E
S
K
I
T
--
V
R
A
T
N
D
L
E
E
-
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
----
E
H
-----
L
L
R
L
----
P
-
V
K
----
P
S
M
V
L
N
L
S
K
G
I
E
I
K
--
T
G
--
K
R
V
S
E
I
V
E
E
I
L
-
G
C
P
Y
----
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
---
G
E
N
---
S
------
K
E
L
Q
K
R
I
S
--
T
--
E
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
---
A
R
F
G
M
F
F
---
G
A
D
---
Q
K
---
T
F
M
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
F
G
E
L
I
A
-
R
-
G
F
N
P
L
K
L
L
----
E
S
S
--
N
Q
V
V
E
G
A
F
T
V
K
A
V
M
K
I
A
K
E
N
K
I
--
D
--
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
-------------
42
HHSearch
89.76
42%
-77
* C1 *
1Z82
7
?
A:
[14-325]
------
E
M
R
F
F
V
L
G
A
G
S
W
G
T
V
F
A
Q
M
L
H
-------
E
N
--
G
E
E
-------
V
I
L
W
A
R
R
K
E
I
-------
V
D
L
----------
I
N
V
S
H
T
S
P
-
Y
V
E
E
S
K
--
I
T
V
R
A
T
N
D
L
E
E
-
I
K
K
E
D
I
L
V
I
A
I
P
V
Q
Y
I
R
-
E
H
L
L
R
-----
L
P
V
--------
K
----
P
S
M
V
L
N
L
S
K
G
I
E
I
K
--
T
G
--
K
R
V
S
E
I
V
E
E
I
L
-
G
--
C
--
P
Y
A
V
L
S
G
P
S
H
A
E
E
V
A
K
K
L
P
T
A
V
T
L
A
---
G
E
N
S
---------
K
E
L
Q
K
R
I
S
--
T
--
E
Y
F
R
V
Y
T
C
E
D
V
V
G
V
E
I
A
G
A
L
K
N
V
I
A
I
A
A
G
I
L
D
G
F
G
G
W
D
N
A
K
A
A
L
E
T
R
G
I
Y
E
I
---
A
R
F
G
M
F
F
---
G
A
D
---
Q
K
---
T
F
M
G
L
A
G
I
G
D
L
M
V
T
C
N
S
R
Y
S
R
N
R
R
F
G
E
L
I
A
-
R
-
G
F
N
P
L
K
L
L
E
S
--
S
N
Q
--
V
V
E
G
A
--
F
T
V
K
A
V
M
K
I
A
K
E
N
K
I
--
D
--
M
P
I
S
E
E
V
Y
R
V
V
Y
E
G
K
P
P
L
Q
S
M
R
D
L
M
R
-------------
10
PsiBlast_PDB
88.41
30%
-87
- C1 -
1X0X
6
GPDA_HUMAN
A:
[6-344]
----
M
A
S
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
-------
G
N
--
A
A
Q
LAQFDPR
V
T
M
W
--
V
F
E
E
D
I
GGKK
L
T
E
I
----------
I
N
T
Q
H
E
N
V
K
Y
L
P
G
H
K
L
P
P
N
V
V
A
V
P
D
V
V
Q
A
A
E
D
A
D
I
L
I
F
V
V
P
H
Q
F
I
G
-
K
I
C
D
Q
-----
L
K
G
H
----
L
-
K
A
----
N
A
T
G
I
S
L
I
K
G
V
D
E
G
--
P
N
--
G
L
--
K
L
I
S
E
V
I
-
G
E
R
L
G
I
P
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
---
C
K
D
P
A
Q
G
------
Q
L
L
K
E
L
M
Q
--
T
--
P
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
L
G
F
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
---
I
A
F
A
K
L
F
---
C
S
G
---
P
V
S
S
A
T
F
L
E
S
C
G
V
A
D
L
I
T
--
T
C
Y
G
G
R
N
R
K
V
A
E
A
F
A
-
R
T
G
K
S
I
E
Q
L
E
----
K
E
L
LN
G
Q
K
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
L
--
V
DK
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
Q
N
H
P
E
H
M
--------
11
PsiBlast_PDB
88.00
30%
-84
- C1 -
1WPQ
6
GPDA_HUMAN
A:
[2-339]
-----
A
S
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
-------
G
N
--
A
A
Q
LAQFDP
R
V
T
M
W
--
V
F
E
E
DIGGKK
L
T
E
I
----------
I
N
T
Q
H
E
N
V
K
Y
L
P
G
H
K
L
P
P
N
V
V
A
V
P
D
V
V
Q
A
A
E
D
A
D
I
L
I
F
V
V
P
H
Q
F
I
G
-
K
I
C
D
Q
-----
L
K
G
H
----
L
-
K
A
----
N
P
T
G
I
S
L
I
K
G
V
D
E
G
--
P
N
--
G
L
--
K
L
I
S
E
V
I
-
G
E
R
L
G
I
P
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
---
C
K
D
P
A
Q
G
------
Q
L
L
K
E
L
M
Q
--
T
--
P
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
L
G
F
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
---
I
A
F
A
K
L
F
---
C
S
G
---
P
V
S
S
A
T
F
L
E
S
C
G
V
A
D
L
I
T
--
T
C
Y
G
G
R
N
R
K
V
A
E
A
F
A
-
R
T
G
K
S
I
E
Q
L
E
----
K
E
L
LN
G
Q
K
L
Q
G
P
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
L
--
V
DK
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
Q
N
H
P
E
H
M
--------
15
PsiBlast_PDB
87.39
29%
-93
- C1 -
4FGW
-
GPD1_YEAST
A:
[36-383]
--------
K
V
T
V
I
G
S
G
N
W
G
T
T
I
A
K
V
V
A
-------
E
N
C
K
G
Y
P
EVFAP
I
-
V
Q
M
W
--
V
F
E
E
E
I
NGEK
L
T
E
I
----------
I
N
T
R
H
Q
N
V
K
Y
L
P
G
I
T
L
P
D
N
L
V
A
N
P
D
L
I
D
S
V
K
D
V
D
I
I
V
F
N
I
P
H
Q
F
L
P
-
R
I
C
S
Q
-----
L
K
G
H
----
V
-
D
S
----
H
V
R
A
I
S
C
L
K
G
F
E
V
G
--
A
K
G
V
Q
L
L
S
S
Y
I
T
E
E
L
-
G
I
Q
C
G
A
----
L
S
G
A
N
I
A
T
E
V
A
Q
E
H
W
S
E
T
T
V
A
Y
H
I
P
K
D
F
R
G
E
GKDVD
H
K
V
L
K
A
L
F
H
--
R
--
P
Y
F
H
V
S
V
I
E
D
V
A
G
I
S
I
C
G
A
L
K
N
V
V
A
L
G
C
G
F
V
E
G
L
G
W
G
N
N
A
S
A
A
I
Q
R
V
G
L
G
E
I
---
I
R
F
G
Q
M
F
FPE
S
R
E
---
E
T
---
Y
Y
Q
E
S
A
G
V
A
D
L
I
T
T
C
A
G
--
G
R
N
V
K
V
A
R
L
M
A
T
S
-
G
K
D
A
W
E
C
E
----
K
E
L
LN
G
Q
S
A
Q
G
L
I
T
C
K
E
V
H
E
W
L
E
T
C
G
S
--
V
ED
F
P
L
F
E
A
V
Y
Q
I
V
Y
N
N
Y
P
M
K
N
-
L
P
D
M
I
E
E
------------
43
HHSearch
86.25
30%
-82
- C1 -
1X0V
7
GPDA_HUMAN
A:
[7-351]
-----
A
S
K
K
V
C
I
V
G
S
G
N
W
G
S
A
I
A
K
I
V
G
G
N
A
A
Q
L
A
Q
F
--
D
P
R
-------
V
T
M
W
V
F
E
E
D
I
GGKK
L
--
T
E
I
----------
I
N
T
Q
H
E
N
V
K
Y
L
P
G
H
K
L
P
P
N
V
V
A
V
P
D
V
V
Q
A
A
E
D
A
D
I
L
I
F
V
V
P
H
Q
F
I
G
-
K
I
C
D
Q
-----
L
K
G
H
----
L
-
K
A
----
N
A
T
G
I
S
L
I
K
G
V
D
E
G
PN
G
L
--
K
L
I
S
E
V
I
G
E
R
L
-
G
-
I
---
P
M
S
V
L
M
G
A
N
I
A
S
E
V
A
D
E
K
F
C
E
T
T
I
G
---
C
K
D
P
A
Q
G
------
Q
L
L
K
E
L
M
Q
--
T
--
P
N
F
R
I
T
V
V
Q
E
V
D
T
V
E
I
C
G
A
L
K
N
V
V
A
V
G
A
G
F
C
D
G
L
G
F
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
---
I
A
F
A
K
L
F
---
C
S
G
PVS
S
A
---
T
F
L
E
S
C
G
V
A
D
L
I
T
T
C
Y
G
--
G
R
N
R
K
V
A
E
A
F
A
-
R
T
G
K
S
I
E
Q
L
E
K
E
LL
N
G
Q
--
K
L
Q
G
P
--
E
T
A
R
E
L
Y
S
I
L
Q
H
K
G
L
VD
K
--
F
P
L
F
M
A
V
Y
K
V
C
Y
E
G
Q
P
V
G
E
F
I
H
C
L
Q
N
H
P
E
H
M
--------
13
PsiBlast_PDB
86.04
29%
-80
- C1 -
2PLA
3
GPD1L_HUMAN
A:
[7-346]
--------
K
V
C
I
V
G
S
G
N
W
G
S
A
V
A
K
I
I
G
-------
N
N
--
V
K
K
-------
L
Q
K
F
A
S
T
V
K
M
W
V
-----
F
E
E
T
V
NGRK
L
T
D
I
I
N
N
D
H
E
N
V
K
Y
L
P
G
H
K
L
P
E
N
V
V
A
M
S
N
L
S
E
A
V
Q
D
A
D
L
L
V
F
V
I
P
H
Q
F
I
H
-
R
I
C
D
E
-----
I
T
G
R
----
V
-
P
K
----
K
A
L
G
I
T
L
I
K
G
I
D
E
G
--
P
---
E
G
L
K
-
L
I
S
D
I
I
-
R
E
K
M
G
I
D
I
S
V
L
M
G
A
N
I
A
N
E
V
A
A
E
K
F
C
E
T
T
I
G
---
S
K
V
M
E
N
G
------
L
L
F
K
E
L
L
Q
--
T
--
P
N
F
R
I
T
V
V
D
D
A
D
T
V
E
L
C
G
A
L
K
N
I
V
A
V
G
A
G
F
C
D
G
L
R
C
G
D
N
T
K
A
A
V
I
R
L
G
L
M
E
M
I
A
F
A
R
I
F
C
K
G
---
Q
V
S
---
T
A
---
T
F
L
E
S
C
G
V
A
D
L
I
T
--
T
C
Y
G
G
R
N
R
R
V
A
E
A
F
A
-
R
T
G
K
T
I
E
E
L
E
----
K
E
M
LN
G
Q
K
L
Q
G
P
Q
T
S
A
E
V
Y
R
I
L
K
Q
K
G
L
--
L
DK
F
P
L
F
T
A
V
Y
Q
I
C
Y
E
S
R
P
V
Q
E
M
L
S
C
L
Q
S
-------------