@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0505: (2015-12-01 )
MSKKTDTPDYKPSIYSLTRDELIAWAIEHGEKKFRASQIWDWLYKKRVQSFDEMTNISKDFIALLNENFVVNPLKQRIVQESADGTVKYLFELPDGMLIETVLMRQYYGLSVCVTTQVGCNIGCTFCASGLIKKQRDLNNGEITAQIMLVQKYFDERGQGERVSHIVVMGIGEPFDNYTNVLKFLRTVNDDNGLAIGARHITVSTSGLAHKIREFANEGVQVNLAVSLHAPNNELRSSIMRINRSFPLEKLFAAIEYYIETTNRRVTFEYIMLNGVNDTPENAQELADLTKKIRKLSYVNLIPYNPVSEHDQYSRSPKERVEAFYDVLKKNGVNCVVRQEHGTDIDAACGQLRSNTMKRDRQKAKVGR
Atome Classification :
(20 SA)
-------------------------------------------.........10........20........30.....--...40......--...50.---.......------60.-----..------...-..70.....-------...80.......------.90.......----------.100..------...-----.----..110......-.-----120.....------..130---.--------.-----------.------....140-----.......--.150.-.----------.-------------.-..---------.160-..--------------.....-170-..-...--.-.-.180-----.....-..190.......200......-----.---210....-....-.220-.--......--230.......240.......250.-----------------......260--..---.---.-....270.......280.......290....---.-..300.-----.......310-.-------.---.--.---..-----------...320--........----.330........340...--....350.......360......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------MSKKTDTPDYKP
S
I
Y
SL
T
R
D
E
L
I
A
W
A
I
EH
G
E
K
K
F
R
A
--
S
Q
I
W
-
D
W
L
Y
K
K
--
R
V
Q
S
F
D
---
E
M
T
N
I
S
K
------
D
F
I
-----
A
L
------
L
NE-NFVV
N
P
L
K
Q
-------
R
I
V
Q
ESADG
T
V
K
------
Y
L
F
ELPD
G
M
L
----------
I
E
-
T
V
L
------
M
R
Q
-----Y----YG
L
S
V
C
V
T
TQV-G-----CN
I
G
C
T
F
C
------
A
S
G
L
I
---
K
--------
K
-----------Q------RDLNNG------
E
I
T
A
Q
I
M
--
L
V
Q
K
Y
-
F
----------
D
-------------E-RG---------QGE
R
-
V
S
--------------
H
I
V
V
M
-G-I-GE-P
F
D
--
N
-
Y
-
T
N
V
L
-----
K
F
L
R
T-VNDDN
G
L
A
I
G
A
R
H
I
T
VSTS
G
L
-----
A
---
H
--
K
I
R
E
-
F
ANE-G
V
Q
V
-
N
--
L
A
V
S
L
H--AP
N
N
E
L
R
S
S
I
M
R
INRSF
P
L
E
K
L
F
A
-----------------
A
I
E
Y
Y
I
ET---TN---
R
---
R
-
V
T
F
E
Y
I
M
LNGVNDTP
E
N
A
Q
E
L
A
D
L
T
K
K
I
R
KL---
S
-
Y
V
N
L
-I-----PYNPVS
E
H
---
D
-------
Q
---Y--S---R
S
-----------
P
K
E
R
----
V
E
A
F
Y
D
V
L
----
K
K-NG
V
N
C
V
V
RQEHGT
D
I
--
D
A
A
C
G
Q
L
R
S
N
T
M
K
R
D
R
Q
K
AKVGR
21
PsiBlast_CBE
98.76
36%
-115
- C4 -
3RF9
2
RLMN_ECOLI
B:
[14-368]
--------------------------------------------------
K
D
G
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
--
D
Q
V
M
-
K
W
M
Y
H
Y
--
C
C
D
N
F
D
---
E
M
T
D
I
N
K
------
V
L
R
-----
G
K
------
L
K
E
-
V
A
E
I
R
A
P
E
V
-------
V
E
E
Q
R
S
S
D
G
T
I
K
------
W
A
I
A
V
G
D
-
Q
R
----------
V
E
-
T
V
Y
------
I
P
E
-----
D
----
D
R
A
T
L
C
V
S
S
Q
V
-
G
-----
C
A
L
E
C
K
F
C
------
S
T
A
Q
Q
---
G
--------
F
-----------
N
------
R
N
L
R
V
S
------
E
I
I
G
Q
V
W
--
R
A
A
K
I
-
V
----------
G
-------------
A
A
K
V
---------
T
G
Q
R
P
I
T
--------------
N
V
V
M
M
-
G
-
M
-
G
E
-
P
L
L
--
N
-
L
-
N
N
V
V
-----
P
A
M
E
I
-
M
L
D
D
F
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
-----
V
---
P
--
A
L
D
K
-
L
G
D
M
--
I
D
V
-
A
--
L
A
I
S
L
H
--
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
-----------------
A
V
R
R
Y
L
E
K
---
S
N
---
A
NQG
R
-
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
-----
C
-
K
I
N
L
-
I
-----
P
W
N
P
F
P
G
A
-----------
P
---
Y
--
G
---
R
S
-----------
S
N
S
R
----
I
D
R
F
S
K
V
L
----
M
S
-
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
------------
D
V
I
D
R
T
K
R
T
L
R
K
R
M
1
PsiBlast_PDB
98.29
36%
-115
- C4 -
3RF9
1
RLMN_ECOLI
A:
[13-368]
-------------------------------------------------
T
K
D
G
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
--
D
Q
V
M
-
K
W
M
Y
H
Y
--
C
C
D
N
F
D
---
E
M
T
D
I
N
K
------
V
L
R
-----
G
K
------
L
K
E
-
V
A
E
I
R
A
P
E
V
-------
V
E
E
Q
R
S
S
D
G
T
I
K
------
W
A
I
A
V
G
D
-
Q
R
----------
V
E
-
T
V
Y
------
I
P
E
-----
D
----
D
R
A
T
L
C
V
S
S
Q
V
-
G
-----
C
A
L
E
C
K
F
C
------
S
T
A
Q
Q
---
G
--------
F
-----------
N
------
R
N
L
R
V
S
------
E
I
I
G
Q
V
W
--
R
A
A
K
I
-
V
----------
G
-------------
A
A
K
V
---------
T
G
Q
R
P
I
T
--------------
N
V
V
M
M
-
G
-
M
-
G
E
-
P
L
L
--
N
-
L
-
N
N
V
V
-----
P
A
M
E
I
-
M
L
D
D
F
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
-----
V
---
P
--
A
L
D
K
-
L
G
D
M
--
I
D
V
-
A
--
L
A
I
S
L
H
--
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
-----------------
A
V
R
R
Y
L
E
K
---
S
N
---
A
NQG
R
-
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
-----
C
-
K
I
N
L
-
I
-----
P
W
N
P
F
P
G
A
-----------
P
---
Y
--
G
---
R
S
-----------
S
N
S
R
----
I
D
R
F
S
K
V
L
----
M
S
-
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
------------
D
V
I
D
R
T
K
R
T
L
R
K
R
M
3
PsiBlast_PDB
96.93
35%
-105
- C4 -
4PL1
2
?
B:
[1-352]
-----------------------------------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
--
D
Q
V
M
-
K
W
M
Y
H
Y
--
C
C
D
N
F
D
---
E
M
T
D
I
N
K
------
V
L
R
-----
G
K
------
L
K
E
-
V
A
E
I
R
A
P
E
V
-------
V
E
E
Q
R
S
S
D
G
T
I
K
------
W
A
I
A
V
G
D
-
Q
R
----------
V
E
-
T
V
Y
------
I
P
E
-----
D
----
D
R
A
T
L
A
V
S
S
Q
V
-
G
-----
C
A
L
E
C
K
F
C
------
S
T
A
Q
Q
---
G
--------
F
-----------
N
------
R
N
L
R
V
S
------
E
I
I
G
Q
V
W
--
R
A
A
K
I
-
V
----------
G
-------------
A
A
K
V
---------
T
G
Q
R
P
I
T
--------------
N
V
V
M
M
-
G
-
M
-
G
E
-
P
L
L
--
N
-
L
-
N
N
V
V
-----
P
A
M
E
I
-
M
L
D
D
F
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
-----
V
---
P
--
A
L
D
K
-
L
G
D
M
--
I
D
V
-
A
--
L
A
I
S
L
H
--
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
-----------------
A
V
R
R
Y
L
E
K
---
S
N
---
A
NQG
R
-
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
-----
C
-
K
I
N
L
-
I
-----
P
W
N
P
F
P
G
A
-----------
P
---
Y
--
G
---
R
S
-----------
S
N
S
R
----
I
D
R
F
S
K
V
L
----
M
S
-
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
I
--
D
A
A
-
G
Q
L
A
G
D
V
I
D
R
T
K
R
T
L
R
K
R
M
2
PsiBlast_PDB
95.63
36%
-118
- C4 -
3RFA
2
RLMN_ECOLI
A:
[17-349]
-----------------------------------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
--
D
Q
V
M
-
K
W
M
Y
H
Y
--
C
C
D
N
F
D
---
E
M
T
D
I
N
K
------
V
L
R
-----
G
K
------
L
K
E
-
V
A
E
I
R
A
P
E
V
-------
V
E
E
Q
R
S
S
D
G
T
I
K
------
W
A
I
A
V
G
D
-
Q
R
----------
V
E
-
T
V
Y
------
I
P
E
-----
D
----
D
R
A
T
L
C
V
S
S
Q
V
-
G
-----
C
A
L
E
C
K
F
C
------
S
T
A
Q
Q
---
G
--------
F
-----------
N
------
R
N
L
R
V
S
------
E
I
I
G
Q
V
W
--
R
A
A
K
I
-
V
----------
G
-------------
A
A
K
V
---------
T
G
Q
R
P
I
T
--------------
N
V
V
M
M
-
G
-
M
-
G
E
-
P
L
L
--
N
-
L
-
N
N
V
V
-----
P
A
M
E
I
-
M
L
D
D
F
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
-----
V
---
P
--
A
L
D
K
-
L
G
D
M
--
I
D
V
-
A
--
L
A
I
S
L
H
--
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
-----------------
A
V
R
R
Y
L
E
K
---
S
N
---
A
NQG
R
-
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
-----
C
-
K
I
N
L
-
I
-----
P
W
N
P
F
P
G
A
-----------
P
---
Y
--
G
---
R
S
-----------
S
N
S
R
----
I
D
R
F
S
K
V
L
----
M
S
-
Y
G
F
T
T
I
V
R
K
T
R
G
D
---------------------------
22
PsiBlast_CBE
94.88
35%
-119
- C4 -
4PL1
2
?
A:
[1-332]
-----------------------------------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
--
D
Q
V
M
-
K
W
M
Y
H
Y
--
C
C
D
N
F
D
---
E
M
T
D
I
N
K
------
V
L
R
-----
G
K
------
L
K
E
-
V
A
E
I
R
A
P
E
V
-------
V
E
E
Q
R
S
S
D
G
T
I
K
------
W
A
I
A
V
G
D
-
Q
R
----------
V
E
-
T
V
Y
------
I
P
E
-----
D
----
D
R
A
T
L
A
V
S
S
Q
V
-
G
-----
C
A
L
E
C
K
F
C
------
S
T
A
Q
Q
---
G
--------
F
-----------
N
------
R
N
L
R
V
S
------
E
I
I
G
Q
V
W
--
R
A
A
K
I
-
V
----------
G
-------------
A
A
K
V
---------
T
G
Q
R
P
I
T
--------------
N
V
V
M
M
-
G
-
M
-
G
E
-
P
L
L
--
N
-
L
-
N
N
V
V
-----
P
A
M
E
I
-
M
L
D
D
F
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
-----
V
---
P
--
A
L
D
K
-
L
G
D
M
--
I
D
V
-
A
--
L
A
I
S
L
H
--
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
-----------------
A
V
R
R
Y
L
E
K
---
S
N
---
A
NQG
R
-
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
-----
C
-
K
I
N
L
-
I
-----
P
W
N
P
F
P
G
A
-----------
P
---
Y
--
G
---
R
S
-----------
S
N
S
R
----
I
D
R
F
S
K
V
L
----
M
S
-
Y
G
F
T
T
I
V
R
K
T
R
G
----------------------------
40
Fugue
93.48
35%
-116
- C4 -
3RFA
2
RLMN_ECOLI
A:
[17-349]
-----------------------------------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
--
D
Q
V
M
-
K
W
M
Y
H
Y
--
C
C
D
N
F
D
---
E
M
T
D
I
N
K
------
V
L
R
-----
G
K
------
L
K
E
-
V
A
E
I
R
A
P
E
V
-------
V
E
E
Q
R
S
S
D
G
T
I
K
------
W
A
I
A
V
-
G
D
Q
R
----------
V
E
-
T
V
Y
------
I
P
E
-----
D
----
D
R
A
T
L
C
V
S
S
Q
V
-
G
-----
C
A
L
E
C
K
F
C
------
S
T
A
Q
Q
---
G
--------
F
-----------
N
------
R
N
L
R
V
S
------
E
I
I
G
Q
V
W
--
R
A
A
K
I
-
V
----------
G
A------------
A
-
K
V
---------
T
G
Q
R
P
I
T
--------------
N
V
V
M
M
-
G
-
M
-
G
E
-
P
L
L
--
N
-
L
-
N
N
V
V
-----
P
A
M
E
I
-
M
L
D
D
F
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
-----
V
---
P
--
A
L
D
K
-
L
G
D
M
--
I
D
V
-
A
--
L
A
I
S
L
H
--
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
-----------------
A
V
R
R
Y
L
E
K
---
S
N
ANQ
G
---
R
-
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
--
T
P
---
C
-
K
I
N
L
-
I
-----
P
W
N
P
F
P
G
A
---
P
-----------
Y
--
G
---
R
S
-----------
S
N
S
R
----
I
D
R
F
S
K
V
L
----
M
S
-
Y
G
F
T
T
I
V
R
K
T
R
G
D
---------------------------
23
HHSearch
92.62
36%
-110
- C4 -
3RFA
2
RLMN_ECOLI
A:
[17-349]
-----------------------------------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
--
D
Q
V
M
-
K
W
M
Y
H
Y
--
C
C
D
N
F
D
---
E
M
T
D
I
N
K
------
V
L
R
-----
G
K
------
L
K
E
-
V
A
E
I
R
A
P
E
V
-------
V
E
E
Q
R
S
S
D
G
T
I
K
------
W
A
I
A
V
G
-
D
Q
R
----------
V
E
-
T
V
Y
------
I
P
E
-----
D
----
D
R
A
T
L
C
V
S
S
Q
V
-
G
-----
C
A
L
E
C
K
F
C
------
S
T
A
Q
Q
---
G
--------
F
-----------
N
------
R
N
L
R
V
S
------
E
I
I
G
Q
V
W
--
R
A
A
K
I
-
V
----------
G
-------------
A
-
A
K
VT-------
G
Q
R
P
-
I
T
--------------
N
V
V
M
M
-
G
-
M
-
G
E
-
P
L
L
--
N
-
L
-
N
N
V
V
-----
P
A
M
E
I
-
M
L
D
D
F
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
-----
V
---
P
--
A
L
D
K
-
L
G
D
M
-
I
-
D
V
-
A
--
L
A
I
S
L
H
--
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
-----------------
A
V
R
R
Y
L
E
K
SNA
N
Q
---
G
---
R
-
V
T
I
E
Y
V
M
L
D
H
V
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
--
T
P
---
C
-
K
I
N
L
-
I
-----
P
W
N
P
F
P
G
----
A
-------
P
---
Y
--
G
---
R
S
-----------
S
N
S
R
----
I
D
R
F
S
K
V
L
----
M
S
-
Y
G
F
T
T
I
V
R
K
T
R
G
D
---------------------------
42
Fugue
58.91
18%
-92
- C4 -
3C8F
3
PFLA_ECOLI
A:
[1-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
I
G
R
I
H
S
--------
F
E
-
S
C
G
------
T
V
D
-----
G
----
P
G
I
R
F
I
T
F
F
Q
--
G
-----
C
L
M
R
C
L
Y
C
------
H
N
R
D
T
WDT
H
--------
G
-----------
G
------
K
E
V
T
V
E
------
D
L
M
K
E
V
V
--
T
Y
R
H
F
-
M
----------
N
-------------
A
-
S
G
---------
G
G
--------------------
V
T
A
S
-
G
---
G
E
-
A
I
L
--
Q
-
A
-
E
F
V
R
-----
D
W
F
R
A
-
C
K
K
E
G
------
I
H
T
C
L
D
T
N
G
F
-----
V
---
R
--
R
Y
D
P
-
V
I
D
E
-
L
L
E
V
-
T
--
D
L
V
M
L
D
LK
Q
M
N
D
E
I
H
Q
N
L
V
G
V
S
-----
N
H
R
T
L
-----------------
E
F
A
K
Y
L
A
N
---
K
N
---
V
---
K
-
V
W
I
R
Y
V
V
V
P
G
W
S
D
D
D
D
S
A
H
R
L
G
E
F
T
R
D
M
G
N
V
---
E
-
K
I
E
L
-
L
-----
P
Y
H
E
L
G
K
H
---
K
-------
W
---
V
--
A
---
M
G
EEYKLDGVKPP
K
K
E
T
----
M
E
R
V
K
G
I
L
----
E
Q
-
Y
G
H
K
V
M
F
---------------------------------
5
PsiBlast_PDB
53.64
19%
-82
- C4 -
3CB8
8
PFLA_ECOLI
A:
[23-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
F
Q
-
G
-----
C
L
M
R
C
L
Y
C
------
H
N
------
R
--------
D
-----------
T
------
W
D
T
H
G
G
K
E
V
T
V
E
D
L
M
K
E
V
V
--
T
Y
R
H
F
-
M
----------
N
-------------
A
-
S
G
---------
G
G
---------------------
V
T
A
-
S
-
G
-
G
E
-
A
I
L
--
Q
-
A
-
E
F
V
R
-----
D
W
F
R
A
-
C
K
K
E
------
G
I
H
T
C
L
D
T
N
G
F
-----
V
---
R
--
R
Y
D
P
-
V
I
D
E
-
L
L
E
V
-
T
DL
V
M
L
D
L
K
--
Q
M
N
D
E
I
H
Q
N
L
V
G
V
S
N
H
R
T
L
E
--
F
A
-----------------
K
---
Y
L
A
N
---
K
N
---
V
---
K
-
V
W
I
R
Y
V
V
V
P
G
W
S
D
D
D
D
S
A
H
R
L
G
E
F
T
R
D
M
G
N
V
---
E
-
K
I
E
L
-
L
-----
P
Y
H
E
L
G
K
H
---
K
-------
W
---
V
--
A
---
M
G
-----------
E
E
Y
K
----
L
D
G
V
K
P
P
K
----
K
E
-
T
M
E
R
V
K
G
I
L
E
Q
Y
G
H
K
--
V
M
F
--------------------
4
PsiBlast_PDB
52.96
19%
-80
- C4 -
3C8F
3
PFLA_ECOLI
A:
[23-207]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
F
F
Q
-
G
-----
C
L
M
R
C
L
Y
C
------
H
N
------
R
--------
D
-----------
T
------
W
D
T
H
G
G
K
E
V
T
V
E
D
L
M
K
E
V
V
--
T
Y
R
H
F
-
M
----------
N
-------------
A
-
S
G
---------
G
G
---------------------
V
T
A
-
S
-
G
-
G
E
-
A
I
L
--
Q
-
A
-
E
F
V
R
-----
D
W
F
R
A
-
C
K
K
E
------
G
I
H
T
C
L
D
T
N
G
F
-----
V
---
R
--
R
Y
D
P
-
V
I
D
E
-
L
L
E
V
-
T
D
L
V
M
L
D
L
K
--
Q
M
N
D
E
I
H
Q
N
L
V
G
V
S
N
H
R
T
L
E
--
F
A
-----------------
K
---
Y
L
A
N
---
K
N
---
V
---
K
-
V
W
I
R
Y
V
V
V
P
G
W
S
D
D
D
D
S
A
H
R
L
G
E
F
T
R
D
M
G
N
V
---
E
-
K
I
E
L
-
L
-----
P
Y
H
E
L
G
K
H
---
K
-------
W
---
V
--
A
---
M
G
-----------
E
E
Y
K
----
L
D
G
V
K
P
P
K
----
K
E
-
T
M
E
R
V
K
G
I
L
E
Q
Y
G
H
K
--
V
M
F
--------------------
43
Fugue
51.62
14%
-61
- C4 -
2YX0
-
TYW1_PYRHO
A:
[11-342]
-----------------------------------------------
K
I
T
V
Q
A
N
P
N
M
P
K
E
V
A
E
L
F
R
K
------------------------------------
Q
H
Y
E
I
V
G
------
R
H
S
-----
G
V
------
K
L
C
-
H
W
L
K
K
S
L
T
E
-------
G
--------------------------------------
R
-
F
C
Y
------
K
Q
K
-----
F
----
Y
G
I
H
S
H
R
C
L
Q
M
-
T
PVLAW
C
T
H
N
C
I
F
C
WRPMEN
F
L
G
T
E
---
L
--------
P
-----------
Q
------
P
W
D
D
P
A
------
F
I
V
E
E
S
I
--
K
A
Q
R
K
-
L
L
I
GYKPKVDK
K
-------------
K
-
F
E
---------
E
A
W
N
-
P
T
--------------
H
A
A
I
S
-
L
-
S
-
G
E
-
P
M
L
----
Y
-
P
Y
M
G
-----
D
L
V
E
E
-
F
H
K
R
-----
G
F
T
T
F
I
V
T
N
G
T
I
-----
P
---
E
--
R
L
E
E
-
M
I
K
E
-
D
K
L
P
T
Q
--
L
Y
V
S
I
T
--
A
P
D
I
E
T
Y
N
S
V
N
I
P
M
I
P
D
G
W
E
R
I
L
R
-----------------
F
L
E
L
M
-
R
D
---
L
P
---
T
---
R
-
T
V
V
R
L
T
L
V
K
G
E
N
M
H
--
S
P
E
K
Y
A
K
L
I
L
K
A
-
R
P
---
M
-
F
V
E
A
-
K
-----
A
Y
M
N
--
R
L
---
T
-------
I
---
N
--
N
---
M
P
-----------
S
H
Q
D
----
I
R
E
F
A
E
A
L
----
V
K
-
H
L
P
G
Y
H
I
E
D
E
Y
E
P
S
R
--
V
V
L
I
M
R
D
D
V
D
P
Q
G
T
G
V
E
G
R
F
I
K
H
31
HHSearch
51.04
15%
-76
- C4 -
1OLT
3
HEMN_ECOLI
A:
[52-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
S
L
Y
V
H
I
P
--
F
-----
C
H
K
L
C
Y
F
C
------
G
C
N
K
I
---
V
--------
T
-----------
R
------
Q
Q
H
K
A
D
------
Q
Y
L
D
A
L
E
--
Q
E
I
V
H
-
R
----------
A
-------------
P
-
L
F
---------
A
G
R
H
-
V
S
--------------
Q
L
H
W
G
-
G
---
G
T
-
P
T
Y
L-
N
-
K
-
A
Q
I
S
-----
R
L
M
K
L
-
L
R
E
N
F
Q
F
-
N
A
D
A
E
I
S
I
E
V
D
P
R
-----
E
IEL
D
--
V
L
D
H
-
L
R
A
E
-
G
-
F
N
-
R
--
L
S
M
G
V
Q
--
D
F
N
K
E
V
Q
R
L
V
N
R
---
E
Q
D
E
E
F
I
F
A
-----------------
L
L
N
H
A
R
E
----
I
G
---
F
---
T
S
T
N
I
-
D
L
I
Y
G
L
P
K
Q
T
P
E
S
F
A
F
T
L
K
R
V
A
E
--
L
N
---
P
D
R
L
S
V
-
F
-----
N
Y
A
H
L
P
T
I
---
F
AAQRKIK
D
---
A
--
D
---
L
P
-----------
S
P
Q
Q
K
L
D
I
L
Q
E
T
I
A
F
L
----
T
Q
-
S
G
Y
Q
F
I
G
M
D
H
F
A
R
P
D
--
D
E
L
A
V
A
Q
R
E
G
V
L
H
R
N
F
Q
G
Y
T
T
Q
G
25
HHSearch
50.88
15%
-77
* C4 *
2YX0
-
TYW1_PYRHO
A:
[11-304]
-----------------------------------------------------------------------------------------------
K
I
T
V
Q
---
A
N
P
N
M
P
K
------
E
V
A
-----
E
L
------
F
R
K
Q
H
Y
E
I
V
G
R
H
---------
S
G
V
K
L
C
H
W
L
K
K
------
S
L
T
--
E
G
R
F
C
----------
Y
K
Q
K
F
Y
------
G
I
H
-----
S
----
H
R
C
L
Q
M
T
P
V
L
A
-
W
-----
C
T
H
N
C
I
F
C
------
W
R
P
M
E
---
N
--------
F
-----------
L
GTELPQ
P
W
D
D
P
A
------
F
I
V
E
E
S
I
--
K
A
Q
R
K
L
L
----------
I
-------------
G
-
Y
K
PKVDK
K
K
F
E
E
A
W
N
-
P
T
--------------
H
A
A
I
S
-
L
-
S
-
G
E
-
P
M
L
--
Y
---
P
Y
M
G
-----
D
L
V
E
E
-
F
-
H
K
R
G
F
-----
T
T
F
I
V
T
N
G
T
-----
I
---
P
E
-
R
L
E
E
M
I
K
E
D
K
L
-
P
T
-
Q
--
L
Y
V
S
I
T
--
A
P
D
I
E
T
Y
N
S
V
N
I
P
M
I
P
D
G
W
E
R
I
L
R
-----------------
F
L
E
L
M
R
D
----
L
P
---
T
---
R
-
T
V
V
R
L
T
L
V
K
G
E
--
N
M
H
S
P
E
K
Y
A
K
L
I
L
K
--
A
R
---
P
M
F
V
E
A
-
K
-----
A
Y
M
-----NRL
T
-------
I
---
N
--
N
---
M
P
-----------
S
H
Q
D
----
I
R
E
F
A
E
A
L
----
V
K
-
H
L
P
G
Y
H
I
E
D
E
Y
E
P
S
R
--
V
V
L
I
M
R
D
D
V
D
P
Q
G
T
G
V
E
G
R
F
I
K
H
26
HHSearch
50.25
20%
-97
- C4 -
1TV8
4
MOAA_STAA8
A:
[13-200]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
D
L
R
L
S
V
T
D
-
R
-----
C
N
F
R
C
D
Y
C
------
M
P
K
E
V
---
F
GDDFVFLP
K
-----------
N
------
E
L
L
T
F
D
------
E
M
A
R
I
A
K
--
V
Y
A
E
------------------------------------------
L
G
-
V
K
--------------
K
I
R
I
T
-
G
---
G
E
-
P
L
M
--
R
---
R
D
L
D
-----
V
L
I
A
K
-
L
N
Q
I
D
G
I
----
E
D
I
G
L
T
T
N
G
L
-----
L
---
L
KK
H
G
Q
K
-
L
Y
D
A
-
G
-
L
R
-
R
--
I
N
V
S
L
D
--
A
I
D
D
T
L
F
Q
S
I
N
N
R
--
N
I
K
A
T
T
I
L
E
-----------------
Q
I
D
Y
A
T
S
----
I
G
---
L
---
N
-
V
K
V
N
V
V
I
Q
K
G
I
--
N
D
D
Q
I
I
P
M
L
E
Y
F
K
D
--
K
H
---
I
-
E
I
R
F
-
I
-----
E
F
M
D
V
G
N
D
---
N
-------
G
---
W
--
D
---
F
S
-----------
K
V
V
T
----
K
D
E
M
L
T
M
I
----
E
Q
-
H
F
E
I
D
P
V
E
P
K
Y
F
G
E
V
--
A
K
Y
Y
R
H
K
D
N
G
V
Q
F
G
L
I
T
S
V
S
Q
S
F
30
HHSearch
49.86
16%
-88
- C4 -
3T7V
3
PYLB_METBF
A:
[61-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
C
F
I
Y
F
S
T
-
Y
-----
C
K
N
Q
C
S
F
C
------
Y
Y
N
C
R
---
N
--------
E
I
N
---------
R
------
Y
R
L
T
M
E
------
E
I
K
E
T
C
K
--
T
L
K
G
------------------------------------------
A
G
-
F
H
--------------
M
V
D
L
T
-
M
---
G
E
D
P
Y
Y
Y
E
D
-
P
-
N
R
F
V
-----
E
L
V
Q
I
-
V
K
E
E
L
G
L
-----
P
I
M
I
S
P
G
L
M
-----
D
---
N
A
-
T
L
L
K
-
A
R
E
K
-
G
-
A
N
-
F
--
L
A
L
Y
Q
E
--
T
Y
D
T
E
L
Y
R
K
L
R
V
---
G
Q
S
F
D
G
R
V
N
-----------------
A
R
R
F
A
K
Q
----
Q
G
---
Y
---
C
-
V
E
D
--
G
I
L
T
G
V
G
N
D
I
E
S
T
I
L
S
L
R
G
M
S
T
--
N
D
---
P
D
M
V
R
V
-
M
-----
T
F
L
P
Q
E
G
----
T
-------
P
---
L
--
E
GFR
D
K
-----------
S
N
L
S
----
E
L
K
I
I
S
V
L
----
R
L
-
M
F
P
K
R
L
I
P
A
S
L
D
L
E
G
--
I
D
G
M
V
L
R
L
N
A
G
A
N
I
V
T
S
I
L
P
P
D
S
27
HHSearch
49.39
15%
-72
- C4 -
2Z2U
-
TYW1_METJA
A:
[50-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
R
C
I
Q
C
T
P
S
V
I
W
-----
C
Q
Q
N
----------------------------SQIKE------
P
------
K
W
E
E
P
E
------
V
V
Y
E
K
I
L
--
A
M
H
K
R
-
I
----------
I
M
G
Y
A
GVLDRVG
E
K
K
-
F
K
---------
E
A
L
E
-
P
K
--------------
H
V
A
I
S
L
S
---
G
E
-
P
T
L
--
Y
---
P
Y
L
D
-----
E
L
I
K
I
-
F
-
H
K
N
G
F
-----
T
T
F
V
V
S
N
G
I
-----
L
---
T
--
D
--
V
-
I
E
K
I
-
E
-
P
T
-
Q
--
L
Y
I
S
L
D
--
A
Y
D
L
D
S
Y
----
G
G
K
-
K
E
Y
W
E
S
I
L
N
-----------------
T
L
D
I
L
K
E
----
K
K
-------
R
-
T
C
I
R
T
T
L
I
R
G
Y
N
---
D
D
I
L
K
F
V
E
L
Y
E
R
--
A
D
---
V
H
F
I
E
L
-
K
-----
S
Y
M
-----------------------
D
---
M
L
-----------
Q
H
D
E
----
I
L
K
L
A
K
M
L
----
D
E
N
S
S
Y
K
L
I
D
D
S
E
D
S
R
V
A
--
L
L
Q
N
E
N
R
K
I
N
P
K
L
----------
24
HHSearch
49.04
14%
-54
- C4 -
2A5H
5
KAMA_CLOSU
A:
[10-316]
--------------------------------------------------------------------------
K
D
V
S
D
--
A
D
W
N
-
D
W
R
W
Q
V
R
N
R
I
E
T
V
E
E
L
K
K
Y
I
P
L
T
K
------
E
E
E
-----
E
G
------
V
A
Q
-
C
V
K
S
L
R
M
A
I
T
P
Y
Y
L
S
L
I
D
P
N
D
P
N
D
P
V
R
K
------
Q
A
I
P
T
A
L
E
L
N
KAAADLEDPL
H
E
-
D
T
D
------
S
P
V
PGLTH
R
----
Y
P
D
R
V
L
L
L
I
T
D
-
M
-----
C
S
M
Y
C
R
H
C
------
T
R
R
R
F
---
A
GQ------
S
-----------
D
------
D
S
M
P
M
E
------
R
I
D
K
A
I
D
--
Y
I
R
N
T
-----------------------------------------
P
Q
-
V
R
--------------
D
V
L
L
S
-
G
---
G
D
-
A
L
L
--
V
-
S
D
E
T
L
E
-----
Y
I
I
A
K
-
L
-
R
E
I
P
-
H
V
E
I
V
R
I
G
S
R
T
P
V
V
LPQRI
T
---
P
E
-
L
V
N
M
-
L
K
K
Y
-
H
-
P
V
-
W
--
L
N
T
H
F
N
--
H
P
N
E
I
-------------
T
E
E
S
T
R
-----------------
A
C
Q
L
L
A
D
----
A
G
---
V
---
P
-
L
G
N
Q
S
V
L
L
R
G
V
N
D
C
V
H
V
M
K
E
L
V
N
K
L
V
K
--
I
R
---
V
R
P
Y
Y
I
-
Y
-----
Q
C
D
L
S
L
G
----
L
-------
E
---
H
--
F
---
R
T
-----------
P
V
S
K
----
G
I
E
I
I
E
G
L
----
R
G
-
H
T
S
G
Y
C
V
P
T
F
V
V
D
A
P
--
G
G
G
G
K
T
P
V
M
P
N
Y
V
I
S
Q
S
H
D
K
V
I
L
45
Fugue
45.73
17%
-51
- C5 -
4O2X
-
MALE_ECOLI
A:
[5-483]
EG
K
L
V
I
W
I
N
GDKG
Y
N
G
L
A
E
V
G
K
K
F
E
K
D
TG
I
K
V
T
V
E
H
P
D
K
L
E
E
K
F
P
Q
V
A
A
T
G
D
G
-
P
D
I
I
F
W
A
H
D
R
F
G
G
Y
A
Q
S
G
L
L
A
E
I
T
P
--
D
K
A
F
Q
D
K
L
Y
P
F
--
T
W
D
A
V
R
---
Y
N
G
K
L
I
A
------
Y
P
I
-----
A
V
E
A
L
S
L
I
Y
N
K
-
D
L
L
P
N
P
P
K
T
-------
W
E
E
I
P
A
L
D
K
E
L
K
A
K
G
K
S
A
L
M
F
N
L
Q
E
P
Y
F
----------
T
W
-
P
L
I
A
A
DGGY
A
F
K
-----
Y
ENGK
Y
D
I
K
D
V
G
V
D
N
A
-
G
-----
A
K
A
G
L
T
F
L
------
V
D
L
I
K
---
N
--------
K
HMNADTD
Y
S
I
A
E
------
A
A
F
N
K
G
------
E
T
A
M
T
I
N
G
P
W
A
W
S
N
-
I
----------
D
-------------
T
-
S
K
---------
V
N
Y
G
-
V
T
V
L
P
T
F
KGQPSK
P
F
V
G
V
L
S
A
-
G
-
I
-
N
A
-
A
S
P
--
N
-
K
-
E
L
A
K
-----
E
F
L
E
N
Y
L
L
T
D
E
G
L
E
A
V
N
K
D
K
P
L
G
A
V
A
L
-----
K
---
S
--
Y
E
E
E
-
L
A
K
D
---
P
R
-
I
--
A
A
T
M
E
N
--
A
Q
K
G
E
I
M
P
N
I
P
Q
------
M
S
A
F
W
Y
-----------------
A
V
R
T
A
V
I
N
A
--
A
S
---
G
---
R
-
Q
T
V
D
E
A
L
A
A
A
Q
T
N
A
A
A
N
L
E
K
I
K
K
L
R
N
V
I
T
S
A
---
W
-
K
V
I
L
-
Y
N
D
DIH
N
F
T
Y
V
T
D
V
---
I
-------
V
---
K
V
V
G
---
Q
I
-----------
S
K
A
K
----
A
H
T
I
T
V
E
A
----
H
S
-
T
G
-
Q
A
L
I
L
S
T
W
K
S
K
A
--
E
K
Y
C
Q
E
L
Q
Q
N
G
L
T
V
S
I
I
H
E
S
---
33
HHSearch
45.38
13%
-77
- C4 -
1R30
4
BIOB_ECOLI
A:
[72-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
T
G
-
A
-----
C
P
E
D
C
K
Y
C
------
P
Q
S
S
R
---
Y
--------
K
TGLEA------
E
------
R
L
M
E
V
E
------
Q
V
L
E
S
A
R
--
K
A
K
A
------------------------------------------
A
G
-
S
T
--------------
R
F
C
M
G
-
A
-
A
W
K
N
-
P
H
E
--
R
D
M
-
P
Y
L
E
-----
Q
M
V
Q
G
-
V
-
K
A
M
G
L
-----
E
A
C
M
-
T
L
G
T
-----
L
---
S
E
S
Q
A
Q
R
-
L
A
N
A
-
G
-
L
D
-
Y
--
Y
N
H
N
L
D
--
T
-
S
P
E
F
Y
G
N
I
I
T
T
---
R
T
Y
Q
E
R
L
D
-----------------
T
L
E
K
V
R
D
----
A
G
---
I
---
K
-
V
C
S
G
--
G
I
V
G
L
G
E
T
V
K
D
R
A
G
L
L
L
Q
L
A
N
--
L
P
TPP
E
-
S
V
P
I
-
N
-----
M
L
V
K
V
K
G
----
T
-------
P
LAD
N
--
D
---
D
V
-----------
D
A
F
D
----
F
I
R
T
I
A
V
A
----
R
I
-
M
M
P
T
S
Y
V
R
L
S
A
G
R
E
Q
--
M
N
E
Q
T
Q
A
M
C
F
M
A
G
A
N
S
I
F
Y
G
C
K
L
48
Fugue
44.60
16%
-37
* C5 *
4R6H
5
MSME_BACSU
A:
[28-421]
-----------------------------------------------
A
D
T
A
K
K
T
L
T
I
Y
S
T
M
S
T
D
S
E
R
D
T
F
R
K
L
A
A
A
F
E
K
E
H
S
D
I
H
-
V
S
L
H
F
P
--
G
-
N
D
Y
E
---
N
M
M
R
V
R
M
A
A
NDLP
D
L
F
D
THGW
G
K
------
I
R
Y
-
G
E
Y
T
A
D
L
R
D
-------
M
K
W
T
Q
D
L
D
P
N
L
N
------
S
I
L
K
N
K
S
G
K
V
----------
Y
A
-
Y
P
I
------
N
Q
A
-----
K
----
D
G
L
A
Y
N
R
N
I
L
D
-
R
-----
Y
G
I
A
P
P
E
T
------
M
D
D
F
I
---
K
--------
A
-----------
L
------
R
T
I
K
E
K
------
S
K
G
S
I
V
P
--
F
W
F
A
G
-
Y
----------
D
-------------
K
-
S
S
---------
F
A
Q
Y
-
Y
D
--------------
Q
F
A
T
P
-
L
L
I
-
T
D
-
P
A
H
--
N
-
E
-
K
K
Q
L
I
N
GTF
Q
W
S
K
F
-
T
Y
L
S
E
I
L
K
Q
M
Q
K
E
K
L
I
N
I
D
A
V
-----
T
---
A
--
K
K
S
Q
-
L
I
E
L
-
M
A
Q
N
-
K
--
I
A
F
T
M
Q
----
G
G
T
L
G
Q
D
V
A
Q
I
N
P
N
V
K
V
G
I
I
P
T
PAIHPG
D
D
P
I
W
I
G
GER
Y
T
L
A
A
W
K
D
S
---
P
Q
---
L
---
K
-
E
A
K
D
F
I
A
F
M
A
---
R
P
A
N
A
K
Q
M
A
E
A
T
S
L
P
S
G
L
---
T
-
N
V
K
A
D
I
-----
F
Y
-----
A
---
N
-------
D
---
Y
--
E
---
Y
Y
-----------
Q
D
V
K
----
V
E
P
Y
F
D
R
L
YLPN
G
M
-
W
D
V
L
G
T
V
G
Q
E
L
A
A
D
I
LA
P
Q
D
I
S
Q
K
L
G
R
E
Y
K
R
L
R
E
Q
S
E
T
--