@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0508: (2015-12-01 )
MKSNQWQVFKRLISYLRPYKWFTVLALSLLLLTTVVKNIIPLIASHFIDHYLTNVNQTAVLILVGYYSMYVLQTLIQYFGNLFFARVSYSIVRDIRRDAFANMERLGMSYFDRTPAGSIVSRITNDTEAISDMFSGILSSFISAIFIFTVTLYTMLMLDIKLTGLVALLLPVIFILVNVYRKKSVTVIAKTRSLLSDINSKLSESIEGIRIVQAFGQEERLKTEFEEINKEHVVYANRSMALDSLFLRPAMSLLKLLAYAVLMSYFGFTGVKGGLTAGLMYAFIQYVNRLFDPLIEVTQNFSTLQTSMVSAGRVFDLIDETGFEPSQKNTEAFVREGNIEFKNVSFSYDGKKQILDNVSFSVKKGETIAFVGATGSGKSSIINVFMRFYEFQSGQVLLDGKDIRDYSQEQLRKNIGLVLQDPFLYHGTIKSNIKMYQDITDQEVQDAAEFVDADQFIQKLPDKYDSAVSERGSSFSTGQRQLLAFARTVASKPKILILDEATANIDSETEQIVQDSLAKMRQGRTTIAIAHRLSTIQDANCIYVLDRGKIIESGNHESLLDQKGTYYRMYQLQAGMMEV
Atome Classification :
(46 SA)
.........10........20.-.......30........40........-----50..----.---.----..--.---.-60----........70........80........90........100.......110.......120.......130-....-.------..140----...---....150.......160.......170..---.....180.......190.....---..200.......210.......--------220.......230...--....240.......250.......260.......270----------....-------...-.280.......290.......300.......310.......320-----..----...-...-----.-330..-..-----.--...340......-.350-.--.--......360.......370.......380.......390---.......400.......410.......420.......430..--.--.--..----.-440.-........450.......460.......470.......480.......490.......500.......510.......520.--.--.......530.......540.......550.......--560--....--..-.570.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKS
N
Q
W
Q
V
F
K
R
L
I
S
Y
LR
P
Y
K
W
F
-
T
V
L
A
L
S
L
L
L
L
T
T
V
V
K
N
I
I
P
L
I
A
S
H
F
I
D
-----
H
Y
L
T----N---V----N
Q
--
T
---
A
-
V
L
----
I
L
V
G
Y
Y
S
M
Y
V
L
Q
T
L
I
Q
Y
F
G
N
L
F
F
A
R
V
S
Y
S
I
V
R
D
I
R
R
D
A
F
A
N
M
E
R
L
G
M
S
Y
FDRTP
A
G
S
I
V
S
R
ITN
D
T
E
A
I
S
D
-
M
F
S
G
-
I
------
L
S
S
F
I
----
S
A
I
---
F
I
F
T
V
T
L
Y
T
M
L
M
L
D
I
K
L
T
G
L
V
A
L
L
L
P
V
I
F
---
I
L
V
N
V
YRKK
S
V
T
V
I
A
K
T
R
S
L
L
S
D
---
I
N
S
K
L
S
E
S
I
E
G
I
R
I
V
Q
A
FG
Q
E
E
--------
R
L
K
T
E
F
E
EINKE
H
V
V
Y--ANRS
M
A
L
D
S
L
F
L
R
P
A
M
S
L
L
K
L
L
A
Y
A
V
L
M
S
Y
F
GFTGV-----------KG
G
L
-------
T
A
G
-
L
M
Y
A
F
I
Q
Y
V
N
R
L
F
D
P
L
I
E
V
T
Q
N
F
S
T
L
Q
T
S
M
VSAG
R
V
F
D
L
I
D
E-------TG----FEP-SQK-----
N
-
T
-
E
A
F
-VR-----E--GN
I
E
F
K
N
V
S
F
SY-D
G
K
--
K
--
Q
--
I
L
D
NV
S
F
S
VKKG
E
T
I
A
F
V
GATGSG
K
S
S
I
I
N
V
F
M
R
F
Y
EFQ---S
G
Q
V
L
LDGKD
I
R
D
Y
S
Q
E
Q
L
R
K
NI
G
L
V
LQDP
F
L
YHGTIKSNI
K
--
M
--
Y
--QD----I-
T
--
D
-
Q
E
V
Q
D
A
A
E
F
V
D
A
D
Q
F
I
Q
KL
P
D
K
Y
D
S
A
V
S
ERGSSFS
T
G
Q
R
Q
L
L
A
F
A
R
T
VASKP
K
I
L
I
L
DEATANID
S
E
T
E
Q
I
V
Q
D
S
L
A
K
M
--R--Q--GR
T
T
I
A
I
A
HRLSTIQDA
N
C
I
Y
V
LDR
G
K
I
IESGNH
E
S
L
--
L
DQ--KG
T
Y
--
Y
R
-
M
Y
Q
LQAGMMEV
4
PsiBlast_PDB
91.26
32%
-121
- C1 -
4Q4H
-
Y288_THEMA
B:
[20-592]
---
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
-----
V
V
F
V
PRRF
D
---
L
----
L
P
--
R
---
Y
-
M
L
----
I
L
---
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
-
S
------
I
I
Q
F
F
----
S
G
I
---
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
---
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
---
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
--------
K
E
M
E
K
F
D
R
V
N
-
E
S
L
R
K
--
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-----------
K
D
I
I
-------
T
V
G
-
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
--------------
L
E
E
-
E
K
D
-----
D
-
P
-
D
A
V
E
L
R
-----
E
VR
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
--
K
--
P
--
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
--
Y
--
G
--
N
P
G---
A
-
T
--
D
-
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
--
I
Q
K
--
R
G
F
Y
--
Y
E
-
L
F
T
S
Q
Y
G
----
2
PsiBlast_PDB
90.80
32%
-125
- C1 -
3QF4
1
Y288_THEMA
B:
[20-594]
---
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
-----
V
V
F
V
PRRF
D
---
L
----
L
P
--
R
---
Y
-
M
L
----
I
L
---
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
-
S
------
I
I
Q
F
F
----
S
G
I
---
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
---
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
---
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
--------
K
E
M
E
K
F
D
R
V
N
-
E
S
L
R
K
--
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-----------
K
D
I
I
-------
T
V
G
-
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
--------------
L
E
E
-
E
K
D
-----
D
-
P
-
D
A
V
E
L
R
-----
E
VR
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
--
K
--
P
--
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
--
Y
--
G
--
N
P
G---
A
-
T
--
D
-
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
--
I
Q
K
--
R
G
F
Y
--
Y
E
-
L
F
T
S
Q
Y
G
L
V
V
E
3
PsiBlast_PDB
90.21
32%
-123
- C1 -
4Q4A
1
Y288_THEMA
B:
[20-593]
---
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
-----
V
V
F
V
PRRF
D
---
L
----
L
P
--
R
---
Y
-
M
L
----
I
L
---
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
-
S
------
I
I
Q
F
F
----
S
G
I
---
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
---
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
---
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
--------
K
E
M
E
K
F
D
R
V
N
-
E
S
L
R
K
--
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-----------
K
D
I
I
-------
T
V
G
-
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
--------------
L
E
E
-
E
K
D
-----
D
-
P
-
D
A
V
E
L
R
-----
E
VR
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
--
K
--
P
--
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
--
Y
--
G
--
N
P
G---
A
-
T
--
D
-
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
--
I
Q
K
--
R
G
F
Y
--
Y
E
-
L
F
T
S
Q
Y
G
L
---
1
PsiBlast_PDB
90.13
32%
-122
- C1 -
4Q4J
-
Y288_THEMA
B:
[20-592]
---
N
P
T
A
T
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
-----
V
V
F
V
PRRF
D
---
L
----
L
P
--
R
---
Y
-
M
L
----
I
L
---
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
-
V
L
G
N
-
S
------
I
I
Q
F
F
----
S
G
I
---
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
L
T
V
---
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
---
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
--------
K
E
M
E
K
F
D
R
V
N
-
E
S
L
R
K
--
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
I
S
G
F
G
G
W
L
A
L
-----------
K
D
I
I
-------
T
V
G
-
T
I
A
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
E
R
I
F
E
I
L
D
--------------
L
E
E
-
E
K
D
-----
D
-
P
-
D
A
V
E
L
R
-----
E
VR
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
--
K
--
P
--
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
---
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
--
Y
--
G
--
N
P
G---
A
-
T
--
D
-
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
--
M
--
E
--
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
--
I
Q
K
--
R
G
F
Y
--
Y
E
-
L
F
T
S
Q
Y
G
----
5
PsiBlast_PDB
89.52
32%
-108
- C1 -
2HYD
3
Y1866_STAAM
A:
[3-576]
---------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
GVINN
H
A
L
T
----
T
D
E
K
V
----
H
H
--
L
---
T
-
I
A
----
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
-
L
------
M
N
I
W
L
----
D
C
I
---
T
I
I
-
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
---
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
---
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
--------
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
--
A
L
K
H
T
R
W
N
A
-
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-----------
S
G
S
I
-------
T
V
G
-
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
DYDIKNG
V
G
----
A
Q
P
-
I
E
--------------
I
K
-----
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
E
--
A
--
P
--
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
--
L
--
G
--
R
P
----
T
A
T
--
D
-
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
--
I
A
K
--
Q
G
A
Y
--
E
H
-
L
Y
S
I
Q
N
L
----
6
PsiBlast_PDB
89.49
32%
-110
- C1 -
2ONJ
4
Y1866_STAAM
A:
[3-576]
---------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
GVINN
H
A
L
T
----
T
D
E
K
V
----
H
H
--
L
---
T
-
I
A
----
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
-
L
------
M
N
I
W
L
----
D
C
I
---
T
I
I
-
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
---
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
---
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
--------
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
--
A
L
K
H
T
R
W
N
A
-
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-----------
S
G
S
I
-------
T
V
G
-
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
DYDIKNG
V
G
----
A
Q
P
-
I
E
--------------
I
K
-----
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
E
--
A
--
P
--
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
--
L
--
G
--
R
P
----
T
A
T
--
D
-
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
--
I
A
K
--
Q
G
A
Y
--
E
H
-
L
Y
S
I
Q
N
L
----
21
PsiBlast_CBE
88.31
32%
-110
- C1 -
2ONJ
4
Y1866_STAAM
B:
[3-576]
---------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
GVINN
H
A
L
T
----
T
DEK
V
----
H
H
--
L
---
T
-
I
A
----
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
-
L
------
M
N
I
W
L
----
D
C
I
---
T
I
I
-
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
---
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
---
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
--------
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
--
A
L
K
H
T
R
W
N
A
-
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-----------
S
G
S
I
-------
T
V
G
-
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
DYDIKNG
V
G
----
A
Q
P
-
I
E
--------------
I
K
-----
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
E
--
A
--
P
--
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
--
L
--
G
--
R
P
----
T
A
T
--
D
-
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
--
I
A
K
--
Q
G
A
Y
--
E
H
-
L
Y
S
I
Q
N
L
----
22
PsiBlast_CBE
88.01
32%
-109
- C1 -
2HYD
3
Y1866_STAAM
B:
[3-576]
---------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
GVINN
H
A
L
T
----
T
DEK
V
----
H
H
--
L
---
T
-
I
A
----
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
-
L
------
M
N
I
W
L
----
D
C
I
---
T
I
I
-
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
---
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
---
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
--------
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
--
A
L
K
H
T
R
W
N
A
-
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-----------
S
G
S
I
-------
T
V
G
-
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
DYDIKNG
V
G
----
A
Q
P
-
I
E
--------------
I
K
-----
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
E
--
A
--
P
--
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
--
L
--
G
--
R
P
----
T
A
T
--
D
-
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
--
I
A
K
--
Q
G
A
Y
--
E
H
-
L
Y
S
I
Q
N
L
----
93
HHSearch
85.46
28%
-106
- C1 -
3WMG
6
?
A:
[17-598]
-----------
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
A
T
L
P
A
F
A
I
V
F
G
R
M
F
Q
-----
V
F
T
K
----
S
---
K
----
S
Q
I
E
G
E--
T
-
W
K
----
Y
S
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
-
S
F
S
K
--------
L
G
A
V
L
----
F
N
L
---
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
---
L
A
V
V
V
Q
M
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
---
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
--------
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
L
--
G
R
R
R
Y
I
S
D
G
L
F
-
F
G
L
S
M
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
-----------
R
G
S
L
-------
N
L
G
-
N
L
L
T
A
F
F
S
A
I
L
G
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
-------
V
P
----
Q
Y
R
-
R
P
D
PG
A
E
V
V
-
T
-
Q
P
L
-
V
L
-----
K
--
Q
G
I
V
F
E
N
V
H
F
R
Y
-
P
T
R
MN
V
--
E
--
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
--
Y
--
G
--
K
R
D---
A
-
T
--
D
-
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
--
M
A
S
D
--
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
--
M
A
L
GP
S
G
F
Y
--
Y
Q
-
L
V
E
K
Q
L
A
S
---
91
HHSearch
83.73
28%
-101
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
-----
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
-----
D
G
F
G
----
K
---
T
----
D
R
--
S
---
V
L
L
W
----
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
-
S
S
S
G
-
A
------
L
I
T
V
V
----
R
E
G
---
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
---
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
---
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
--------
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
--
G
M
K
M
V
S
A
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-----------
M
D
S
L
-------
T
A
G
-
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
-------
E
Q
----
E
K
D
-
E
G
K
-----
R
-
V
-
I
D
--
R
A
-----
T
--
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
E-
V
--
P
--
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
--
Y
--
A
--
R
T
EE--
Y
-
S
--
R
-
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
--
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
--
L
A
Q
--
H
G
V
Y
--
A
Q
-
L
H
K
M
Q
F
G
----
80
Fugue
82.98
28%
-100
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
-----
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
-----
D
G
F
G
----
K
---
T
----
D
R
--
S
---
V
-
L
L
W---
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
-
S
S
S
G
-
A
------
L
I
T
V
V
----
R
E
G
---
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
---
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
---
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
--------
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
--
G
M
K
M
V
S
A
S
S
I
-
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-----------
M
D
S
L
-------
T
A
G
-
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
-------
E
Q
-----
E
K
-
D
E
G
-----
K
-
R
-
V
I
D
-
R
A
-----
T
--
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
--
E
--
V
P-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
--
Y
AR
T
--
E
E
----
Y
-
S
--
R
-
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
--
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
--
L
A
Q
--
H
G
V
Y
--
A
Q
-
L
H
K
M
Q
F
G
----
12
PsiBlast_PDB
81.60
28%
-105
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
-----
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
-----
D
G
F
G
----
K
---
T
----
D
R
--
S
---
V
-
L
L
W
M
P
L
V
V
I
G
---
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
-
S
S
S
G
-
A
------
L
I
T
V
V
R
E
G
A
S
I
I
---
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
----
I
L
V
V
L
A
P
I
V
S
---
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
---
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
--------
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
--
G
M
K
M
V
S
A
S
S
I
S
-
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
F
P
S
V
-----------
M
D
S
L
-------
T
A
G
-
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
S
-------
E
------
Q
E
-
K
D
E
-----
G
-
K
-
R
V
I
-
D
R
-----
A
T-
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
--
E
V-
P
--
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
---
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
YA
R
--
T
--
E
E
----
Y
-
S
--
R
-
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
--
Q
--
K
--
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
--
L
A
Q
--
H
G
V
Y
--
A
Q
-
L
H
K
M
Q
F
G
----
92
HHSearch
78.93
29%
-101
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[6-572]
-------
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
-----
V
I
Y
T
----
N
---
P
----
T
V
--
D
Y
S
D
N
L
T
R
----
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
-
S
V
T
E
-
N
------
L
S
D
G
L
----
R
A
G
---
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
---
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
---
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
--------
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
--
A
R
K
E
A
F
A
R
A
G
F
-
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
-----------
S
A
H
M
-------
T
V
G
-
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
-------
E
P
----
K
L
P
-
F
N
E
-----
G
V
I
L
N
E
K
-
S
F
-----
Q
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
PE
V
--
P
--
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
--
Y
--
G
--
A
D
DPSS
V
-
T
--
A
-
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
--
L
S
K
P---------------------
18
PsiBlast_PDB
77.95
29%
-102
- C1 -
4AYW
3
ABCBA_HUMAN
A:
[39-598]
---------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
-----
V
I
Y
T
----
N
---
P
TVD
Y
S
D
--
N
---
L
-
T
R
----
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
-
S
V
T
E
-
N
------
L
S
D
G
L
----
R
A
G
---
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
---
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
---
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
-----------
M
T
E
I
E
K
-------
Y
--
A
S
K
---
V
D
H
V
-----
M
Q
L
A
R
K
E
A
F
A
-
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
LMGSAHM
T
V
G
-
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
-------
E
P
----
K
L
P
-
F
N
E
G
V
I
L
-
N
-
E
-
K
S
F
--------
Q
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
--
P
--
E
VP
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
--
Y
--
G
--
A
D
DPSS
V
-
T
--
A
-
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
--
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
----------------------------
16
PsiBlast_PDB
77.84
29%
-97
- C1 -
4AYX
7
ABCBA_HUMAN
A:
[8-574]
---------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
-----
V
I
Y
T
----
N
---
P
TVDY
S
D
--
N
---
L
-
T
R
----
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
-
S
V
T
E
-
N
------
L
S
D
G
L
----
R
A
G
---
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
---
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
---
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
-----------
M
T
E
I
E
K
-------
Y
--
A
S
K
---
V
D
H
V
-----
M
Q
L
A
R
K
E
A
F
A
-
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
AHM
T
V
G
-
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
--------------
E
P
-
K
L
P
-----
F
-
N
-
E
G
V
-
I
L
N
EKSF
Q
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
--
P
--
E
VP
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
--
Y
--
G
--
A
D
DPSS
V
-
T
--
A
-
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
--
L
S
K
--
P
N
G
-----------------
25
PsiBlast_CBE
77.83
32%
-100
- C1 -
3WMG
3
?
A:
[73-595]
------------------------------------------------------------------------------------------
V
G
F
V
G
I
G
V
F
E
F
I
V
A
G
S
R
T
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
-
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
----
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
---
I
A
L
S
P
L
V
V
L
A
V
V
V
Q
M
---
I
E
M
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
---
V
F
S
N
-------
I
R
T
T
K
A
F
-
E
A
E
--------
R
Y
E
T
Q
-
R
Y
G
S
K
L
D
P
L
Y
R
L
G
R
R
R
Y
I
S
D
G
L
F
F
G
L
S
M
-
L
V
I
F
C
V
Y
A
L
A
L
W
W
G
G
Q
L
I
A
-----------
R
G
S
L
-------
N
L
G
N
L
L
T
A
F
F
S
A
I
L
G
-
F
M
G
V
G
Q
A
A
Q
V
W
P
D
V
T
R
G
L
G
A
G
G
E
L
F
A
M
I
D
R
-------
V
P
QYRR
P
D
P
G
A
E
V
-----
V
-
T
-
Q
P
L
-
V
L
-----
K
--
Q
G
I
V
F
E
N
V
H
F
R
Y
-
P
T
R
--
M
NV
E
--
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
D
I
E
PQG
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
---
L
--
Y
GK
R
D
----
A
-
T
--
D
-
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
--
D
--
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
N
H
S
E
L
M
A
L
G
P
--
S
G
F
Y
--
Y
Q
-
L
V
E
K
Q
L
A
S
---
15
PsiBlast_PDB
76.13
29%
-95
- C1 -
4AYT
8
ABCBA_HUMAN
A:
[8-567]
---------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
-----
V
I
Y
T
----
N
---
P
TVDY
S
D
--
N
---
L
-
T
R
----
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
-
S
V
T
E
-
N
------
L
S
D
G
L
----
R
A
G
---
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
---
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
---
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
-----------
M
T
E
I
E
K
-------
Y
--
A
S
K
---
V
D
H
V
-----
M
Q
L
A
R
K
E
A
F
A
-
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
AHM
T
V
G
-
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
--------------
E
P
-
K
L
P
-----
F
-
N
-
E
G
V
-
I
L
N
EKSF
Q
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
--
P
--
E
VP
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
--
Y
--
G
--
A
D
DPSS
V
-
T
--
A
-
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
----------------------------
17
PsiBlast_PDB
75.60
29%
-96
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[8-572]
---------
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
-----
V
I
Y
T
----
N
---
P
TVDY
S
D
--
N
---
L
-
T
R
----
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
-
S
V
T
E
-
N
------
L
S
D
G
L
----
R
A
G
---
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
---
I
I
A
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
---
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
-----------
M
T
E
I
E
K
-------
Y
--
A
S
K
---
V
D
H
V
-----
M
Q
L
A
R
K
E
A
F
A
-
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
S
V
L
Y
K
G
G
L
L
M
G
S
AHM
T
V
G
-
E
L
S
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
L
G
A
G
G
R
L
W
E
L
L
E
R
--------------
E
P
-
K
L
P
-----
F
-
N
-
E
G
V
-
I
L
N
EKSF
Q
--
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
--
P
--
E
VP
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
---
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
--
Y
--
G
--
A
D
DPSS
V
-
T
--
A
-
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
--
M
--
D
--
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
--
L
S
K
--
P
-------------------
7
PsiBlast_PDB
72.78
32%
-107
- C1 -
4A82
-
Y1866_STAAM
A:
[3-576]
---------
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
GVINN
H
A
L
T
----
T
D
E
K
V
----
H
H
--
L
---
T
-
I
A
----
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
-
L
------
M
N
I
W
L
----
D
C
I
---
T
I
I
-
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
---
L
T
V
Y
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
---
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
--------
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
R
--
A
L
K
H
T
R
W
N
A
-
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
V
I
G
V
G
A
Y
L
A
I
-----------
S
G
S
I
-------
T
V
G
-
T
L
A
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
F
A
S
M
D
R
V
F
Q
L
I
D
E
DYDIKNG
V
G
----
A
Q
P
-
I
E
--------------
I
K
-----
Q
--
G
R
I
D
I
D
H
V
S
F
Q
Y
N
D
N
E
--
A
--
P
--
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
---
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
--
L
--
G
--
R
P
----
T
A
T
--
D
-
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
--
K
--
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
--
I
A
K
--
Q
G
A
Y
--
E
H
-
L
Y
S
I
Q
N
L
----
13
PsiBlast_PDB
72.11
31%
-105
- C1 -
4RY2
-
?
A:
[211-722]
-----------------------------------------------------------------------------------
I
----
I
S
A
G
F
A
V
I
F
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
-
A
I
S
G
A
T
------
L
T
I
M
I
----
D
T
I
-------
M
A
V
I
G
G
I
L
L
Y
I
Q
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
V
F
N
K
---
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
D
K
I
E
T
V
M
K
S
S
F
K
E
G
M
L
Y
--
I
N
---------
L
S
S
L
T
G
I
V
A
G
L
G
G
I
V
I
L
W
A
G
A
Y
N
V
I
-----------
K
G
N
M
-------
S
G
G
-
Q
L
L
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
V
V
A
S
N
R
L
G
E
I
L
E
L
-------
A
T
----
E
K
E
-
L
-------------------------
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
R
--
K
--
P
--
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
---
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
--
L
--
G
--
N
E
----
N
-
V
--
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
--
E
--
D
--
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
--
I
A
L
--
K
G
C
Y
--
F
K
-
M
W
K
Q
T
E
N
T
---
57
PsiBlast_CBE
57.69
41%
-93
- C1 -
1XEF
3
HLYBP_ECOLX
B:
[1-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
58
PsiBlast_CBE
57.45
41%
-92
- C1 -
1XEF
3
HLYBP_ECOLX
A:
[1-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
56
PsiBlast_CBE
57.40
41%
-96
- C1 -
1XEF
3
HLYBP_ECOLX
C:
[1-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
39
PsiBlast_CBE
57.00
42%
-94
- C1 -
2PMK
1
A:
[3-242]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
41
PsiBlast_CBE
56.33
41%
-92
- C1 -
2FGK
2
D:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
43
PsiBlast_CBE
55.92
41%
-92
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
53
PsiBlast_CBE
55.83
41%
-91
- C1 -
2FGJ
2
HLYBP_ECOLX
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
55
PsiBlast_CBE
55.54
41%
-90
- C1 -
1XEF
3
D:
[1-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
52
PsiBlast_CBE
55.17
41%
-88
- C1 -
2FGJ
2
HLYBP_ECOLX
B:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
51
PsiBlast_CBE
54.93
41%
-88
- C1 -
2FGJ
2
HLYBP_ECOLX
C:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
44
PsiBlast_CBE
54.43
41%
-89
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
50
PsiBlast_CBE
54.17
41%
-91
- C1 -
2FGJ
2
D:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
A
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
42
PsiBlast_CBE
54.00
41%
-88
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[7-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
F
R
N
I
R
F
R
Y
-
K
P
D
--
S
--
P
V-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
---
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
--
L
--
A
--
N
P
G---
M
-
S
--
V
-
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
--
C
--
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
--
L
S
E
--
P
E
S
L
--
Y
S
Y
L
Y
Q
L
Q
S
D
----
30
PsiBlast_CBE
53.33
44%
-79
- C1 -
3NH9
3
A:
[50-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----
K
--
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
G
--
R
--
E
--
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
-----
Y
--
G
R
----
V
-
T
AG
N
-
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
--
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
--
L
S
R
--
G
G
V
Y
--
A
D
-
M
W
Q
L
Q
Q
G
Q
---
98
HHSearch
53.00
34%
-79
* C1 *
2IXE
4
TAP1_RAT
A:
[13-256]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-----
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
PN
V
--
Q
--
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
--
Y
--
G
--
L
T
R
T
--
P
-
T
--
M
-
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
E
W
A
--
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
--
M
E
R
--
G
G
C
Y
--
R
S
-
M
V
E
A
-------
28
PsiBlast_CBE
52.99
44%
-81
- C1 -
3NHB
3
A:
[50-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----
K
--
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
---
R
--
E
--
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
-----
Y
--
G
R
----
V
-
T
AG
N
-
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
--
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
--
L
S
R
--
G
G
V
Y
--
A
D
-
M
W
Q
L
Q
Q
G
Q
---
66
PsiBlast_CBE
52.79
33%
-83
- C1 -
2IXF
4
D:
[14-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
--
P
NV
Q
--
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
--
L
L
F
G
R
S
F
R
E
N
I
A
YG
L
--
T
--
R
T
----
P
-
T
--
M
-
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
--
M
E
R
--
G
G
C
Y
--
R
S
-
M
V
E
A
-------
71
PsiBlast_CBE
52.19
33%
-81
- C1 -
2IXE
4
TAP1_RAT
A:
[14-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
--
P
NV
Q
--
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
YG
L
--
T
--
R
T
----
P
-
T
--
M
-
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
N
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
W
A
S
R
T
V
L
L
I
T
Q
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
--
M
E
R
--
G
G
C
Y
--
R
S
-
M
V
E
A
-------
29
PsiBlast_CBE
52.00
44%
-82
- C1 -
3NHA
4
A:
[50-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----
K
--
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
---
R
--
E
--
T
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
---
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
-----
Y
--
G
R
----
V
-
T
AG
N
-
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
--
C
--
A
--
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
--
L
S
R
--
G
G
V
Y
--
A
D
-
M
W
Q
L
Q
Q
G
Q
---
69
PsiBlast_CBE
51.54
33%
-81
- C1 -
2IXF
5
TAP1_RAT
A:
[14-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
--
P
NV
Q
--
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
YG
L
--
T
--
R
T
----
P
-
T
--
M
-
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
--
M
E
R
--
G
G
C
Y
--
R
S
-
M
V
E
A
-------
68
PsiBlast_CBE
50.54
33%
-82
- C1 -
2IXF
4
TAP1_RAT
B:
[14-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--
G
L
V
K
F
Q
D
V
S
F
A
Y
-
P
N
H
--
P
NV
Q
--
V
L
Q
G
L
T
F
T
L
Y
P
G
K
V
T
A
L
V
G
P
N
G
S
G
K
S
T
V
A
A
L
L
Q
N
L
Y
Q
P
T
---
G
G
K
V
L
L
D
G
E
P
L
V
Q
Y
D
H
H
Y
L
H
T
Q
V
A
A
V
G
Q
E
P
L
L
F
G
R
S
F
R
E
N
I
A
YG
L
--
T
--
R
T
----
P
-
T
--
M
-
E
E
I
T
A
V
A
M
E
S
G
A
H
D
F
I
S
G
F
P
Q
G
Y
D
T
E
V
G
E
T
G
N
Q
L
S
G
G
Q
R
Q
A
V
A
L
A
R
A
L
I
R
K
P
R
L
L
I
L
D
Q
A
T
S
A
L
D
A
G
N
Q
L
R
V
Q
R
L
L
Y
E
S
--
P
--
E
WA
S
R
T
V
L
L
I
T
H
Q
L
S
L
A
E
R
A
H
H
I
L
F
L
K
E
G
S
V
C
E
Q
G
T
H
L
Q
L
--
M
E
R
--
G
G
C
Y
--
R
S
-
M
V
E
A
-------
48
PsiBlast_CBE
49.41
42%
-73
- C1 -
1MV5
2
LMRA_LACLA
B:
[5-242]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
-
D
D
S
--
E
--
Q
--
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
YG
L
--
E
--
G
D
----
Y
-
T
--
D
-
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
--
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
--
V
A
T
--
H
P
L
Y
AK
Y
V
-
S
E
Q
L
T
V
G
----
47
PsiBlast_CBE
49.23
42%
-80
- C1 -
1MV5
3
LMRA_LACLA
C:
[5-242]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
-
D
D
S
--
E
--
Q
--
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
YG
L
--
E
--
G
D
----
Y
-
T
--
D
-
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
--
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
--
V
A
T
--
H
P
L
Y
AK
Y
V
-
S
E
Q
L
T
V
G
----
99
HHSearch
48.15
41%
-83
- C1 -
1MV5
3
LMRA_LACLA
A:
[2-239]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
S
--
E
--
Q
--
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
--
Y
--
G
--
L
E
GD--
Y
-
T
--
D
-
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
--
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
--
V
A
T
--
H
P
L
Y
--
A
K
-
Y
V
S
E
Q
L
T
V
G
--
46
PsiBlast_CBE
45.01
42%
-76
- C1 -
1MV5
3
D:
[5-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
-
D
D
S
--
E
--
Q
--
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
YG
L
--
E
--
G
D
----
Y
-
T
--
D
-
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
--
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
--
V
A
T
--
H
P
L
Y
AK
Y
V
-
S
E
Q
L
T
V
-----
49
PsiBlast_CBE
44.84
42%
-73
- C1 -
1MV5
3
LMRA_LACLA
A:
[5-242]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
V
D
F
A
Y
-
D
D
S
--
E
--
Q
--
I
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
---
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
YG
L
--
E
--
G
D
----
Y
-
T
--
D
-
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
--
M
--
K
--
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
--
V
A
T
--
H
P
L
Y
A
K
Y
V
-
S
E
Q
L
T
V
G
----