@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0514: (2015-12-01 )
MLESLKTIVKTNSDKKLFDGDLQVSYGEFYNLVRQDMASQDNRKHVISTHSLLNQLVRFVSKLCQKALPIICKPNLTHNEISRLEKEVQYAPQLADFGVLSSGTTADAKLLWRSFASWSDFFSIQNAYFSVTSNSRLFIQGDFSFTGNLNLVLSLLLLGGTLVVTQKNSVKYWQTLWEKTGVTHLYLLPSYLKLVEQYSKETALDNKTIITSSQYVSDSLLEGLYIKHPKVSVKIFYGASELNYVSWYDGRDIRDKPQYVGEIVPNVAVRIKEGRIFVKTPYSICGLSSEYCAGDYGELIDGKLYLFGRGDDWCNQSGIKLYLPRLIEKIKTCPYIKDAVAFTKESQSHGQESHCCIVLIENQMQQECLKWLSEHFEKKYGFKHYHIVSKIPLMPSGKIDYQQLKRQLA
Atome Classification :
(20 SA)
-----------------------------------------------------.........10....-....----20-----.-----.......--------.30...-----------------...-------..40....------....50........60........70........80......-------------------------------------------------------------------------..90....------------.------------------------------------...100....---...110.......120.-.-.-..----.--.130-........140.......-150.-........160..---..-.----.--.170......---.180.......190...---....200---.-----..----...---...210........220.......--230.......240-..---.--.-..-.-.250-.----.--......260....-...270---------.---------------------------------.---.-------------......-----280-.....------.-------------------..290--------------........-.300-----------------------------------.........310.......320.......330........340.....-..350......------.360---------..--.....370--...-..-....380.-.......390----.........400.......--------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------M
L
E
S
L
K
T
I
V
KTNSDK-KLFD----G------D-----
L
Q
V
S
Y
G
E
--------
F
Y
N
L
V
R
-----------------
Q
D
M
-------ASQDNR
K
H
------
V
I
S
T
H
S
L
L
N
Q
L
V
R
F
V
S
K
L
C
Q
KAL
P
I
I
CKPNL
T
H
N
E
I
S
R
L
E
K
E
-------------------------------------------------------------------------
V
Q
YAPQLA------------D------------------------------------FGVLSSGT
T
A
---
D
A
K
L
L
W
R
S
FA
S
W
S
D
F
F
S
-I-
Q
-
N
A
----
Y
--
F
S
V--TSN
S
R
L
F
I
Q
GDFSFTG
N
L
-
N
--
L
-
V
L
S
L
L
LLG
G
T
L
V
V
---
T
Q-K----N--S
V
K
Y
W
Q
T
L
W
E
---KTG
V
T
H
L
Y
L
L
P
S
Y
L
K
L
V
---
E
Q
Y
S
K
-----
E
-----TA----LDN---
K
T
I
I
T-S
S
Q
Y
V
S
D
S
L
L
E
G
L
Y
IKHP--
K
V
S
V
K
I
F
YGASE--
L
N
---
Y
--
V
-
S
W-Y-DGR--D----I--RD
K
P
Q
Y
V
G
E
IVPN-
V
A
V
R
-----------
I
---------------------------------K---E-------------
G
R
I
F
V
K-----T
P
--
Y
S
ICG------L-------------------S
S
E
----------------YCAGD
Y
G
E
-LI-------------------------------------DG
K
L
Y
L
F
GRGDDWCNQS
G
I
K
L
Y
L
P
R
L
I
E
K
I
-KTCPY
I
K
D
A
V
A
FTKESQ-SHGQES
H
C
C
I
V
------
L
I
E
N
---------
Q
M
--
Q
Q
E
C
L
K
----
W
L
S
-
E
H
-
F
E
K
KY-GF-
K
H
Y
H
I
V
S
K------IPLMPSGKI
D
Y
Q
Q
L
K
R
QLA--------------------------------------------------------------------------------
32
HHSearch
88.68
18%
-98
- C6 -
3R44
2
FAC13_MYCTU
A:
[19-511]
------------------------------------------------------
G
W
M
L
R
Q
R
A
T
V
S
P
R
L
Q
A
Y
V
E
PS--
T
------
D
-----
V
R
M
T
Y
A
Q
--------
M
N
A
L
A
N
-----------------
R
C
A
D
V
L
T
A
L
-
G
I
A
K
G
D
R
V
------
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
GSK
V
V
I
Y
G
APS
A
P
V
I
D
A
I
R
A
QADPPGTVT
D
W
I
G
A
D
S
L
A
E
R
L
R
S
AAADEPA----------------------
V
E
C
G
G
D
D
N
------------
L
------------------------------------
F
I
M
Y
T
S
---
G
---
H
P
K
G
V
V
H
T
H
E
S
V
H
S
A
A
S
-
S
-
W
-
A
S
----
T
--
I
D
V
--
R
Y
R
D
R
L
L
L
P
L
P
M
F
H
V
A
A
L
-
T
--
T
-
V
I
F
S
A
M
R
G
V
T
L
I
S
---
M
P
-
Q
----
F
--
D
A
T
K
V
W
S
L
I
V
---
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
---
R
Q
V
P
E
-----
F
A
E
L--
D
A
----
P
D
F
---
R
Y
F
I
T
-
G
G
A
P
M
P
E
A
L
I
K
I
Y
A
A
K
----
N
I
E
V
V
Q
G
Y
A
L
T
E
--
S
C
---
G
G-
G
-
T
L
-
L
-
L
S
E
--
D
----
A
--
L
R
K
A
G
S
A
G
R
A
T
M
F
-
T
D
V
A
-----------
V
---------------------------------
R
---
G
DDGVIREHGE---
G
E
V
V
I
K
-----
S
D
--
I
L
L
K
E
------
Y
WNR
P
E
A
T
R
D
A
F
D-------
N
G
W
----------------
F
R
T
G
D
I
G
E
-
I
D
D------------------------------------
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
-
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
-
K
W
G
E
I
A
A
A
I
V
V
------
A
D
Q
N
E--------
V
S
--
E
Q
Q
I
V
E
----
Y
C
G
-
T
R
-
L
A
R
Y
K
-
L
P
-
K
K
V
I
F
A
E
A
------
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
--------------------------------------------------------------------------------
34
HHSearch
88.34
18%
-83
- C6 -
1MDB
4
DHBE_BACSU
A:
[28-529]
------------------------------------------------------
G
D
L
L
R
D
R
A
A
K
Y
G
D
R
I
A
I
T
C
----
G
------
N
-----
T
H
W
S
Y
R
E
--------
L
D
T
R
A
D
-----------------
R
L
A
A
G
F
Q
K
L
-
G
I
Q
Q
K
D
R
V
------
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
EAA
A
Y
I
I
P
DAYSGFD
Y
R
S
L
A
R
Q
V
Q
S
K
L
PTLK
N
I
I
V
AGEAEEFLPLEDLHTEPVKL-----------------
P
E
V
K
S
S
D
V
------------
A
------------------------------------
F
L
Q
L
S
G
G
S
T
G
---
L
S
K
L
I
P
R
T
H
D
D
Y
I
Y
S
L
K
-
R
-
S
-
V
E
----
V
--
C
W
L
--
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
-
S
SP
G
-
V
L
G
V
L
Y
A
G
G
R
V
V
L
---
S
P
-
S
----
P
--
S
P
D
D
A
F
P
L
I
E
---
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
---
M
D
A
A
S
S
RR--
D
-----
D
L
----
S
S
L
---
Q
V
L
Q
V
-
G
G
A
K
F
S
A
E
A
A
R
R
V
K
A
V
F
---
G
C
T
L
Q
Q
V
F
G
M
A
E
--
G
L
---
V
--
N
-
Y
T
-
R
-
L
D
D
--
P
----
E
--
E
I
I
V
N
T
Q
G
K
P
M
S
P
Y
D
E
S
R
-----------
V
---------------------------------
W
---
D
DHDRDVKPG
E
T
--
G
H
L
L
T
R
-----
G
P
--
Y
T
I
R
G
------
Y
YKA
E
E
H
N
A
A
S
F
TE------
D
G
F
----------------
Y
R
T
G
D
I
V
R
-
L
T
R------------------------------------
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
-
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
-
F
L
G
E
R
S
C
V
F
I
I
------
P
R
D
E
A--------
P
K
--
A
A
E
L
K
A
----
F
L
R
-
E
R
G
L
A
A
Y
K
-
I
P
-
D
R
V
E
F
V
E
S
------
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
--------------------------------------------------------------------------------
45
HHSearch
87.93
17%
-102
- C6 -
1T5H
1
?
X:
[5-502]
------------------------------------------------------
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
PA--
R
------
G
-----
L
R
L
T
H
A
E
--------
L
R
A
R
V
E
-----------------
A
V
A
ARLHAD-
G
L
R
P
Q
Q
R
V
------
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
E
L
I
K
R
GEMTAAVIAVQVADAIFQSGSGARIIFLGDLVRDGEPYSYGPPIED---------------------------
P
Q
R
E
P
A
Q
P
------------
A
------------------------------------
F
I
F
Y
T
S
---
G
---
L
P
K
A
A
I
I
P
Q
R
A
A
E
S
R
V
L
-
F
-
M
-
S
T
----
Q
--
V
G
L
RH
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
-
F
--
A
V
L
V
A
A
L
A
L
D
G
T
Y
V
V
---
V
E
-
E
----
F
--
R
P
V
D
A
L
Q
L
V
Q
---
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
---
A
A
A
A
A
-----
H
AGSSL
K
L
----
D
S
L
---
R
H
V
T
F
-
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
L
---
P
G
E
K
V
N
I
Y
G
T
T
E
--
A
M
---
N
--
S
-
L
Y
-
M
-
R
Q
P
--
K
----
T
---
G
---
T
E
M
A
P
G
F
F
-
S
E
V
R
IVRIGGGVDEI
V
---------------------------------
A
NGE
E
-------------
G
E
L
I
V
A
-----
A
S
D-
S
A
F
V
G
------
Y
LNQPQATAEKLQ-------
D
G
W
----------------
Y
R
T
S
D
V
A
V
-
W
T
P------------------------------------
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
-
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
-
R
W
G
Q
S
V
T
A
C
V
V
------
P
R
L
G
ET-------
L
S
--
A
D
A
L
D
T
----
F
C
R
S
S
E
-
L
A
D
F
K
-
R
P
-
K
R
Y
F
I
L
D
Q
------
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
--------------------------------------------------------------------------------
37
HHSearch
87.61
20%
-86
* C6 *
3NI2
4
?
A:
[26-532]
-------------------------------------------------------
S
Y
V
L
E
N
L
S
N
H
S
S
K
P
C
L
I
N
----
G
AN----
G
-----
D
V
Y
T
Y
A
D
--------
V
E
L
T
A
R
-----------------
R
V
A
S
G
L
N
K
I
-
G
I
Q
Q
G
D
V
I
------
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
RAK
L
L
I
T
Q
ACYYEKV
K
D
F
A
R
E
S
D
V
K
V
M
C
VDSAPDGCLH
F
S
E
L
T
Q
ADENEAPQ--------------------
V
D
I
S
P
D
D
V
------------
V
------------------------------------
A
L
P
Y
S
S
G
T
T
G
---
L
P
K
G
V
M
L
T
H
K
G
L
I
T
S
V
A
-
Q
-
Q
-
V
D
GDNP
N
--
L
Y
F
--
H
S
E
D
V
I
L
C
V
L
P
M
F
H
I
Y
A
L
-
N
S-
I
-
M
L
C
G
L
R
V
G
A
P
I
L
I
---
M
P
-
K
----
F
--
E
I
G
S
L
L
G
L
I
E
---
K
Y
K
V
S
I
A
P
V
V
P
P
V
M
M
S
I
---
A
K
S
P
D
-----
L
DKH--
D
L
----
S
S
L
---
R
M
I
K
S
-
G
G
A
P
L
G
K
E
L
E
D
T
V
R
A
K
F
P
--
Q
A
R
L
G
Q
G
Y
G
M
T
E
--
A
G
---
P
--
V
-
L
A
-
M
-
C
L
A
--
F
AKEP
F
--
D
I
K
P
G
A
C
G
T
V
V
R
N
-
A
E
M
K
-----------
I
---------------------------------
V
---
D
PETG
A
S
L
P
R
NQP-
G
E
I
C
I
R
-----
G
D
--
Q
I
M
K
G
------
Y
LND
P
E
A
T
S
R
T
I
DK------
E
G
W
----------------
L
H
T
G
D
I
G
Y
-
I
D
D------------------------------------
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
-
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
-
D
A
G
E
V
P
V
A
F
V
V
------
K
S
E
K
SQ-------
A
T
--
E
D
E
I
K
Q
----
Y
I
S
-
K
Q
-
V
I
F
Y
K
-
R
I
-
K
R
V
F
F
I
E
A
------
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
----------------------------------------------------------------------------------
40
HHSearch
87.34
19%
-93
- C6 -
3E7W
2
DLTA_BACSU
A:
[4-499]
------------------------------------------------------
L
H
A
I
Q
T
H
A
E
T
Y
P
Q
T
D
A
F
R
S
----
Q
------
G
-----
Q
S
L
T
Y
Q
E
--------
L
W
E
Q
S
D
-----------------
R
A
A
A
A
I
Q
K
R
I
S
G
E
K
K
S
P
I
------
L
V
Y
G
H
M
E
P
H
M
I
V
S
F
L
G
S
V
K
A
G
H
P
Y
I
P
V
D
L
S
I
P
S
E
R
I
A
K
I
I
E
S
S
GAE
L
L
I
H
AAGLSIDAVGQQIQTVS
A
E
E
L
L
ENEG
G
S
V
S
QD---------------------------------
Q
W
V
K
E
H
E
T
------------
F
------------------------------------
Y
I
I
Y
T
S
G
S
T
G
---
N
P
K
G
V
Q
I
S
A
A
N
L
Q
S
F
T
D
-
W
-
I
-
C
A
----
D
--
F
P
V
--
S
G
G
K
I
F
L
N
Q
A
P
F
S
F
D
L
S
V
-
M
--
D
-
L
Y
P
C
L
Q
S
G
G
T
L
H
C
---
V
T
-
K
D
A
V
-
N
--
K
P
K
V
L
F
E
E
L
K
---
K
S
G
L
N
V
W
T
S
T
P
S
F
V
Q
M
C
---
L
M
D
P
G
FSQ--
D
-----
L
L
----
P
H
A
---
D
T
F
M
F
-
C
G
E
V
L
P
V
S
V
A
K
A
L
L
E
R
F
P
--
K
A
K
I
F
N
T
Y
G
P
T
E
--
A
T
---
V
--
A
-
V
T
S
V
-
E
I
T
--
N
D
V
I
-
S
--
R
S
E
S
L
P
V
G
F
A
K
P
D
-
M
N
I
F
-----------
I
---------------------------------
M
---
D
EEG
Q
P
L
P
E
G
E
K
--
G
E
I
V
I
A
-----
G
P
--
S
V
S
R
G
------
Y
LGE
P
E
L
T
E
K
A
F
F
S
H
EG---
Q
W
A
----------------
Y
R
T
G
D
A
G
F
-
I
Q
-------------------------------------
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
-
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
Y
Q
P
N
-
G
T
V
E
Y
L
I
A
A
I
V
------
P
E
E
H
EFEK
E
F
---
Q
L
--
T
S
A
I
K
K
----
E
L
A
-
A
S
-
L
P
A
Y
M
-
I
P
-
R
K
F
I
Y
Q
D
H
------
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
G
E
E
V
L
--------------------------------------------------------------------------------
28
HHSearch
86.24
21%
-98
- C6 -
3WVN
1
?
A:
[48-441]
------------------------------------------------------
H
D
L
L
A
D
S
G
K
A
T
P
N
S
D
A
M
E
D
----
A
------
F
-----
G
T
W
T
Y
Q
E
--------
L
L
N
H
S
Q
-----------------
A
F
S
A
W
L
D
G
K
-
G
V
A
R
G
E
R
I
------
V
V
Q
L
P
N
I
R
Q
T
V
A
V
F
Y
G
A
C
R
R
G
V
V
F
V
P
L
N
P
G
M
K
P
F
H
L
R
S
V
I
A
D
A
DPR
L
V
I
A
ED
E
T
A
A
D
R
L
R
D
V
TD
L
P
V
Y
S
I
D
S
L
W
A
D
V
E
R
L
R
D
A
GAGAEA--------------------------
V
E
V
S
P
E
D
L
------------
A
------------------------------------
V
L
I
Y
T
S
G
S
T
A
---
A
P
K
A
V
A
C
P
H
Q
Q
I
V
F
A
A
S
-
S
-
I
-
N
A
----
V
--
L
G
Y
--
H
A
E
D
I
V
F
C
R
M
S
V
S
W
D
F
G
L
-
Y
--
K
-
V
L
I
S
T
L
T
G
A
K
L
V
L
---
A
-----------
D
I
A
L
V
K
S
L
R
---
E
S
G
A
T
M
M
P
I
V
P
S
L
A
S
M
L
---
T
T
L
I
R
R
D
P--
E
-----
G
A
----
P
T
L
---
R
M
F
T
N
-
S
A
A
A
L
P
Q
V
T
I
D
A
L
R
S
A
F
P
--
G
A
Q
V
V
R
M
Y
G
Q
T
E
--
C
K
---
R
--
I
-
S
I
-
M
-
P
P
H
--
L
----
E
--
H
E
R
P
D
S
V
G
L
P
L
P
G
-
T
T
I
E
-----------
I
---------------------------------
L
----TLLPPGEP-----
G
E
I
T
V
T
-----
G
P
--
H
V
M
A
G
------
Y
WRA
P
E
I
T
A
R
A
Y---------
M
R
----------------
L
H
T
G
D
Y
G
H
-
L
D
E------------------------------------
D
G
F
L
Y
F
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
85.18
18%
-101
- C6 -
3IPL
-
MENE_STAAN
A:
[2-477]
------------------------------------------------------
D
F
W
L
Y
K
Q
A
Q
Q
N
G
H
H
I
A
I
T
D
----
G
------
Q
-----
E
S
Y
T
Y
Q
N
--------
L
Y
C
E
A
S
-----------------
L
L
A
K
R
L
----
K
A
Y
Q
Q
S
R
V
------
G
L
Y
I
D
N
S
I
Q
S
I
I
L
I
H
A
C
W
L
A
N
I
E
I
A
M
I
N
T
R
L
T
P
N
E
M
T
N
Q
M
R
S
I
DVQ
L
I
F
C
T
L
P
L
E
L
R
GFQIVSLDDESPSNILN-----------------------------------------
T
S
F
N
L
D
D
I
------------
A
------------------------------------
S
I
M
F
T
S
G
T
T
G
---
P
Q
K
A
V
P
Q
T
F
R
N
H
Y
A
S
A
I
-
G
-
C
-
K
E
----
S
--
L
G
F
--
D
R
D
T
N
W
L
S
V
L
P
I
Y
H
I
S
G
L
-
S
--
V
-
L
L
R
A
V
I
E
G
F
T
V
R
I
---
V
D
-
K
----
F
--
N
A
E
Q
I
L
T
M
I
K
---
N
E
R
I
T
H
I
S
L
V
P
Q
T
L
N
W
L
---
M
Q
Q
G
L
-----
H
-----
E
P
----
Y
N
L
---
Q
K
I
L
L
-
G
G
A
K
L
S
A
T
M
I
E
T
A
L
Q
Y
----
N
L
P
I
Y
N
S
F
G
M
T
E
--
T
C
---
S
--
Q
-
F
L
-
T
A
T
P
E
--
M
----
L
--
H
A
R
P
D
T
V
G
M
P
S
A
N
-
V
D
V
K
-----------
I
---------------------------------
K
---
N
PNKEGH-------
G
E
L
M
I
K
-----
G
A
--
N
V
M
N
G
------
Y
LYPTDLTGTFE--------
N
G
Y
----------------
F
N
T
G
D
I
A
E
-
I
D
H------------------------------------
E
G
Y
V
M
I
Y
D
R
R
K
D
L
I
I
S
G
G
E
N
I
Y
P
Y
Q
I
E
T
V
A
-
K
Q
F
P
G
I
S
D
A
V
C
V
G
H
P
D
D
-
T
W
G
Q
V
P
K
L
Y
F
V
------
S
E
S
D
---------
I
S
--
K
A
Q
L
I
A
----
Y
L
S
-
K
H
-
L
A
K
Y
K
-
V
P
-
K
H
F
E
K
V
D
T
------
L
P
-------------------------------------------------------------------------------------------------
31
HHSearch
84.13
16%
-96
- C6 -
3C5E
7
ACS2A_HUMAN
A:
[54-559]
--------------------------------------------------------------
G
K
R
P
P
S
P
A
L
W
W
----
V
------
N
GKG
K
E
L
M
W
N
F
R
E
--------
L
S
E
N
S
Q
-----------------
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
------
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
KAK
A
I
V
A
G
DEV
I
Q
E
V
D
T
V
ASECPSLR
I
K
L
L
VSE
K
S
C
D
GWLN
F
K
K
L
L
N
E
ASTTHHC-----------------
V
E
T
G
S
Q
E
A
------------
S
------------------------------------
A
I
Y
F
T
S
G
T
S
G
---
L
P
K
M
A
E
H
S
Y
S
S
L
G
L
K
A
K
-
M
-
D
-
A
G
----
W
--
T
G
L
--
Q
A
S
D
I
M
W
T
I
S
D
T
G
W
I
L
N
I
-
L
C-
S
-
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L-
L
P
-
K
----
F
--
D
P
L
V
I
L
K
T
L
S
---
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
R
M
L
---
L
Q
Q
D
L
-----
S
SY---
K
F
----
P
H
L
---
Q
N
C
V
T
-
V
G
E
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
D
I
R
E
S
Y
G
Q
T
E
--
T
G
---
L
--
T
-
C
M
-
V
-
S
K
T
-------
M
--
K
I
K
P
G
Y
M
G
T
A
A
S
C
-
Y
D
V
Q
-----------
I
---------------------------------
I
---
D
DKG
N
V
L
P
P
G
T
E
--
G
D
I
G
I
R
VKP
I
R
P
I
--
G
I
F
S
G
------
Y
VDN
P
D
K
T
A
A
N
IR-------
G
D
F
----------------
W
L
L
G
D
R
G
I
-
K
D
E------------------------------------
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
-
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
-
V
R
G
E
V
V
K
A
F
V
V
------
L
A
S
Q
FLSHD
P
E
--
Q
L
--
T
K
E
L
Q
Q
----
H
V
K
-
S
V
-
T
A
P
Y
K
-
Y
P
-
R
K
I
E
F
V
L
N
------
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
--------------------------------------------------------------------------------
5
PsiBlast_PDB
82.47
21%
-86
- C6 -
3E7W
2
DLTA_BACSU
A:
[149-501]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Y
T
S
G
S
T
G
---
N
P
K
G
V
Q
I
S
A
A
N
L
Q
S
F
T
D
-
W
-
I
-
C
A
----
D
--
F
P
V
--
S
G
G
K
I
F
L
N
Q
A
P
F
S
F
D
L
S
V
-
M
--
D
-
L
Y
P
C
L
Q
S
G
G
T
L
H
C
---
V
T
-
K
----
D
--
A
V
N
K
P
K
V
L
F
E
E
L
K
K
S
G
L
N
V
W
T
S
T
P
S
F
V
Q
M
C
L
M
D
P
G
F
S
Q
-----
D
-----
L
L
----
P
H
A
---
D
T
F
M
F
-
C
G
E
V
L
P
V
S
V
A
K
A
L
L
E
R
F
P
--
K
A
K
I
F
N
T
Y
G
P
T
E
AT
V
A
---
V
--
T
-
S
V
-
E
-
I
T
N
--
D
----
V
I
S
R
S
E
S
L
P
V
G
F
A
K
P
D
-
M
N
I
F
-----------
I
M
D
EEG
Q
P
L
P
E
G----------------------
E
---
K
-------------
G
E
I
V
I
A
-----
G
P
--
S
V
S
R
G
------
Y
-------------------
L
G
E
P
E
L
T
E
K
A
F
F
S
H
EGQWA
Y
R
T
G
D
A
G
F
-
I
Q
-------------------------------------
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
-
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
Y
Q
P
N
-
G
T
V
E
Y
L
I
A
A
I
V
------
P
E
E
H
---------
E
F
--
E
K
E
F
Q
L
----
T
S
A
-
I
K
-
K
E
L
A
A
-
S
L
-
P
A
Y
M
I
P
R
K
F
I
Y
Q
D
H
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
G
E
E
V
L
--------------------------------------------------------------------------------
46
HHSearch
82.28
18%
-98
- C6 -
1AMU
4
GRSA_ANEMI
A:
[42-525]
------------------------------------------------------
H
Q
L
F
E
E
Q
V
S
K
R
P
N
N
V
A
I
V
C
----
E
------
N
-----
E
Q
L
T
Y
H
E
--------
L
N
V
K
A
N
-----------------
Q
L
A
R
I
F
I
E
K
-
G
I
G
K
D
T
L
V
------
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
QAR
M
L
L
T
Q
KHL
V
H
L
I
H
N
I
QFN
G
Q
V
E
I
FEEDTIKIREGTNLH-------------------------------
V
P
S
K
S
T
D
L
------------
A
------------------------------------
Y
V
I
Y
T
S
--------
P
K
G
T
M
L
E
H
K
G
I
S
N
L
K
V
-
F
-
F
-
E
N
----
S
--
L
N
V
--
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
-
W
--
E
-
M
F
M
A
L
L
T
G
A
S
L
Y
I
---
I
L
-
K
D
T
I
-
N
--
D
F
V
K
F
E
Q
Y
I
N
---
Q
K
E
I
T
V
I
T
L
P
P
T
Y
V
V
H
L
---
D
P
E
-------------
R
I
----
L
S
I
---
Q
T
L
I
T
-
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
-----
K
V
T
Y
I
N
A
Y
G
P
T
E
--
T
T
---
I
--
C
-
A
T
-
T
-
W
V
A
T
K
E
----
T
--
I
G
H
S
V
P
I
G
A
P
I
Q
N
-
T
Q
I
Y
-----------
I
---------------------------------
V
---
D
ENLQLKSVGEA--
G
E
L
C
I
G
-----
G
E
--
G
L
A
R
G
------
Y
WKR
P
E
L
T
S
Q
K
F
VDNPFVPG
E
K
L
----------------
Y
K
T
G
D
Q
A
R
-
W
L
S------------------------------------
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
-
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
D
H
-
Q
E
Q
P
Y
L
C
A
Y
F
V
------
S
E
K
H
---------
I
P
--
L
E
Q
L
R
Q
----
F
S
S
-
E
E
-
L
P
T
Y
M
-
I
P
-
S
Y
F
I
Q
L
D
K
------
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
D
L
--------------------------------------------------------------------------------
29
HHSearch
82.24
16%
-85
- C6 -
2D1S
3
LUCI_LUCCR
A:
[26-541]
------------------------------------------------------
G
T
Q
L
R
K
Y
M
E
R
Y
A
K
L
G
A
I
A
F
TNAV
T
------
G
-----
V
D
Y
S
Y
A
E
--------
Y
L
E
K
S
C
-----------------
C
L
G
K
A
L
Q
N
Y-
G
L
V
V
D
G
R
I
------
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
SKPTIVFSSKK
G
L
D
K
V
I
T
V
Q
K
T
VTTI
K
T
I
V
ILDSKVDYRGYQ
C
L
D
T
F
I
K
R
N
TPPGFQAS
S
F
K
T
V
---------
E
V
D
R
K
E
Q
V
------------
A
------------------------------------
L
I
M
N
S
S
G
S
T
G
---
L
P
K
G
V
Q
L
T
H
E
N
I
V
T
R
F
S
-
H
-
A
-
R
D
PIY-
G
--
N
Q
V
--
S
P
G
T
A
V
L
T
V
V
P
F
H
H
G
F
G
M
-
F
--
T
-
T
L
G
Y
L
I
C
G
F
R
V
V
M
---
L
T
-
K
----
F
--
D
E
E
T
F
L
K
T
L
Q
---
D
Y
K
C
T
S
V
I
L
V
P
T
L
F
A
I
L
---
N
K
S
E
L
LNK--
Y
-----
D
L
----
S
N
L
---
V
E
I
A
S
-
G
G
A
P
L
S
K
E
V
G
E
A
V
A
R
R
F
N
--
L
P
G
V
R
Q
G
Y
G
L
T
E
--
T
T
---
S
--
A
-
I
I
-
I
-
T
P
E
--
G
-------
D
D
K
P
G
A
S
G
K
V
V
P
L
-
F
K
A
K
-----------
V
---------------------------------
I
---
D
LDT
K
K
S
L
G
PNR
R
-
G
E
V
C
V
K
-----
G
P
--
M
L
M
K
G
------
Y
VN
N
P
E
A
T
K
E
L
IDE------
E
G
W
----------------
L
H
T
G
D
I
G
Y
-
Y
D
E------------------------------------
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
-
L
Q
H
P
S
I
F
D
A
G
V
A
G
V
P
D
P
-
V
A
G
E
L
P
G
A
V
V
V
------
L
E
S
G
K
N
-------
M
T
--
E
K
E
V
M
D
----
Y
V
A
-
S
Q
-
V
S
N
A
K
R
L
R
-
G
G
V
R
F
V
D
E
------
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
I
L
K
--------------------------------------------------------------------------------
43
HHSearch
81.23
19%
-90
- C6 -
3L8C
-
DLTA_STRP6
A:
[2-505]
------------------------------------------------------
I
D
S
I
E
Q
F
A
Q
T
Q
A
D
F
P
V
Y
D
C
----
L
------
G
-----
E
R
R
T
Y
G
Q
--------
L
K
R
D
S
D
-----------------
S
I
A
A
F
I
D
S
L
-
A
L
L
A
K
S
P
V
------
L
V
F
G
A
Q
T
Y
D
M
L
A
T
F
V
A
L
T
K
S
G
H
A
Y
I
P
V
D
V
H
S
A
P
E
R
I
L
A
I
I
E
I
A
KPSLIIAIEEFP
L
T
I
E
G
I
S
L
V
S
L
S
E
I
E
S
A
K
L
A
E
M
P
Y
E
R
T---------------------------------
H
S
V
K
G
D
D
N
------------
Y
------------------------------------
Y
I
I
F
T
S
---
G
---
Q
P
K
G
V
Q
I
S
H
D
N
L
L
S
F
T
N
-
W
-
M
-
I
E
----
D
AA
F
D
V
--
P
K
Q
P
Q
M
L
A
Q
P
P
Y
S
F
D
L
S
V
-
M
--
Y
-
W
A
P
T
L
A
L
G
G
T
L
F
A
---
L
P
-
K
E
L
V
-
A
--
D
F
K
Q
L
F
T
T
I
A
---
Q
L
P
V
G
I
W
T
S
T
P
S
F
A
D
M
A
---
M
L
S
D
D
FCQ--
A
-----
K
M
----
P
A
L
---
T
H
F
Y
F
-
D
G
E
E
L
T
V
S
T
A
R
K
L
F
E
R
F
P
--
S
A
K
I
I
N
A
Y
G
P
T
E
--
A
T
---
V
--
A
L
S
A
-
I
-
E
I
T
--
R
E
M
V
-
D
--
N
Y
T
R
L
P
I
G
Y
P
K
P
D
-
S
P
T
Y
-----------
I
---------------------------------
I
---
D
EDG
K
E
L
S
S
GEQ--
G
E
I
I
V
T
-----
G
P
--
A
V
S
K
G
------
Y
LNN
P
E
K
T
A
E
A
F
F
T
F
KG---
Q
P
A
----------------
Y
H
T
G
D
I
G
S
-
L
T
E------------------------------------
D
N
I
L
L
Y
G
G
R
L
D
F
Q
I
K
-----
I
E
L
E
D
V
S
Q
Q
L
-
N
Q
S
P
M
V
A
S
A
V
A
V
P
R
Y
N
K
E
H
K
---
L
L
A
Y
I
V
------
V
K
D
G
V
K
E
R
F
DR
E
L
E
L
--
T
K
A
I
K
A
----
S
V
K
-
D
H
-
M
M
S
Y
M
-
M
P
-
S
K
F
L
Y
R
D
S
------
L
P
L
T
P
N
G
K
I
D
I
K
T
L
I
N
E
V
N
--------------------------------------------------------------------------------
6
PsiBlast_PDB
80.08
21%
-82
- C6 -
3E7X
1
DLTA_BACSU
A:
[149-501]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Y
T
S
G
S
T
G
---
N
P
K
G
V
Q
I
S
A
A
N
L
Q
S
F
T
D
-
W
-
I
-
C
A
----
D
--
F
P
V
--
S
G
G
K
I
F
L
N
Q
A
P
F
S
F
D
L
S
V
-
M
--
D
-
L
Y
P
C
L
Q
S
G
G
T
L
H
C
---
V
T
-
K
----
D
--
A
V
N
K
P
K
V
L
F
E
E
L
K
K
S
G
L
N
V
W
T
S
T
P
S
F
V
Q
M
C
L
MD
P
G
F
S
Q
-----
D
-----
L
L
----
P
H
A
---
D
T
F
M
F
-
C
G
E
V
L
P
V
S
V
A
K
A
L
L
E
R
F
P
--
K
A
K
I
F
N
T
Y
G
P
T
E
AT
V
A
---
V
--
T
-
S
V
-
E
-
I
T
N
--
D
----
V
I
S
R
S
E
S
L
P
V
G
F
A
K
P
D
-
M
N
I
F
-----------
I
MDEEG
Q
P
L
P
EG----------------------
E
---
K
-------------
G
E
I
V
I
A
-----
G
P
--
S
V
S
R
G
------
Y
-------------------
L
G
E
P
E
L
T
E
K
A
F
FSHEG
Q
W
A
Y
R
T
G
D
A
G
F
-
I
Q
-------------------------------------
D
G
Q
I
F
C
Q
G
R
L
D
F
Q
I
K
L
H
G
Y
R
M
E
L
E
E
I
E
F
H
V
-
R
Q
S
Q
Y
V
R
S
A
V
V
I
P
Y
Q
P
N
-
G
T
V
E
Y
L
I
A
A
I
V
------
P
E
E
H
---------
E
F
--
E
K
E
F
Q
L
----
T
S
A
-
I
K
-
K
E
L
A
A
-
S
L
-
P
A
Y
M
I
P
R
K
F
I
Y
Q
DH
I
Q
M
T
A
N
G
K
I
D
R
K
R
I
G
E
E
V
L
--------------------------------------------------------------------------------
49
Fugue
80.02
18%
-91
- C6 -
4DG9
1
?
A:
[18-604]
------------------------------------------NSLLDLYAHPT
V
V
A
R
F
S
E
M
A
A
L
H
P
H
R
-
E
A
I
R
D---
R
------
F
-----
G
S
V
D
Y
R
Q
--------
L
L
D
S
A
E
-----------------
Q
L
S
-------
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
-------------------------------------------------------------------------
V
D
C
R
L
I
L
D
------------
C
STTPTPANGLPCVPVRHLPAAPA
S
V
A
R
PCFAADQIA
Y
I
N
F
S
S
G
T
T
G
---
R
P
K
A
I
A
C
T
H
A
G
I
T
R
L
C
L
-
G
-
Q
-
S
-----
F
--
L
A
F
--
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
-
L
--
E
-
I
W
G
A
L
L
N
G
G
C
C
V
L
---
N
D
-
L
----
G
PL
D
P
G
V
L
R
Q
L
I
G
---
E
R
G
A
D
S
A
W
L
T
A
S
L
F
N
T
L
---
V
D
L
D
P
-----
D
-----
C
L
----
G
G
L
---
R
Q
L
L
T
-
G
G
D
I
L
S
V
P
H
V
R
R
A
L
L
R
H
P
--
R
L
H
L
V
N
G
Y
G
P
T
E
--
N
T
TFT
C
--
C
-
H
V
-
V
-
T
D
D
--
D
----
L
--
E
E
D
D
I
P
I
G
K
A
I
A
G
-
T
A
V
L
-----------
L
L
D
EHGQEIAEPD
R
A
G
E
I
V
A
F
G
AGLAQGYRND
A
A
R
---
T
-------------
R
A
S
F
V
E
-----
L
P
--
Y
R
G
-
R
------
L
-------------------
L
R
A
----------------
Y
R
T
G
D
R
A
R
Y
D
E
-------------------------------------
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
-
R
R
Q
P
G
I
L
D
C
A
L
L
V
R
E
-
R
-
N
G
V
K
Q
L
L
C
A
W
T
------
G
K
A
D
---------
A
S
--
P
Q
A
L
L
R
----
Q
L
P
-
T
W
-
Q
R
-----
P
-
H
A
C
V
R
V
E
A
------
L
P
L
T
A
H
G
K
L
D
R
A
A
L
L
R
R
L
E
LDP
D
Q
R
G
C
A
Q
L
W
S
E
L
L
G
C
E
V
G
ADFFLCGGN
S
L
L
A
L
Q
L
V
A
L
C
Q
S
A
GAGANLGLADLQANSR
L
D
Q
F
S
R
L
L
R
S
H
GLAPERLLE
27
HHSearch
79.97
17%
-85
- C6 -
1RY2
1
ACS1_YEAST
A:
[86-635]
-------------------------------------------------------
N
C
V
D
R
H
A
L
K
T
P
N
K
K
A
I
I
F
----
E
G
DEPGQ
G
-----
Y
S
I
T
Y
K
E
--------
L
L
E
E
V
C
-----------------
Q
V
A
Q
V
L
T
YSM
G
V
R
K
G
D
T
V
------
A
V
Y
M
P
M
V
P
E
A
I
I
T
L
L
A
I
S
R
I
G
A
I
H
S
V
V
F
A
G
F
S
S
N
S
L
R
D
R
I
N
D
G
DSK
V
V
I
T
T
D
E
S
N
R
GG
K
V
I
E
T
K
R
I
V
D
D
A
L
RETPGVR
H
V
L
V
Y
RKTNNPS
V
A
F
H
A
PRDLD
W
A
T
E
K
K
K
Y
KT
Y
Y
P
C
-
T
P
V
D
S
E
D
P
------------
L
------------------------------------
F
L
L
Y
T
S
G
S
T
G
---
A
P
K
G
V
Q
H
S
T
A
G
Y
L
L
G
A
L
L
T
-
M
-
R
Y
----
T
--
F
D
T
--
H
Q
E
D
V
F
F
T
A
G
D
I
G
W
I
T
G
H
-
T
Y-
V
-
V
Y
G
P
L
L
Y
G
C
A
T
L
V
---
F
E
-
G
TPAY
P
--
N
Y
S
R
Y
W
D
I
I
D
---
E
H
K
V
T
Q
F
Y
V
A
P
T
A
L
R
L
L
---
K
R
A
G
D
SYIEN
H
-----
S
L
----
K
S
L
---
R
C
L
G
S
-
V
G
E
P
I
A
A
E
V
W
E
W
Y
S
E
K
I
G
KN
E
I
P
I
V
D
T
Y
W
Q
T
E
--
S
G
---
S
H-
L
-
V
T
-
P
-
L
A
G
G-
V
----
T
--
P
M
K
P
G
S
A
S
F
P
F
F
G
-
I
D
A
V
-----------
V
---------------------------------
L
---
D
PNTGE
E
L
N
T
S
H
A
E
G
V
L
A
V
K
-----
A
A
WP
S
F
A
R
T
------
I
WKNH
D
R
Y
L
D
T
YLNPY----
P
G
Y
----------------
Y
F
T
G
D
G
A
A
-
K
D
K------------------------------------
D
G
Y
I
W
I
L
G
R
V
D
D
V
V
N
V
S
G
H
R
L
S
T
A
E
I
E
A
A
I
-
I
E
D
P
I
V
A
E
C
A
V
V
G
F
N
D
D
-
L
T
G
Q
A
V
A
A
F
V
V
------
L
K
---------------
L
Q
D
I
K
K
H
L
V
F
T
V
R
-
K
D
-
I
G
P
F
A
-
A
P
-
K
L
I
I
L
V
D
D
------
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
L
A
--------------------------------------------------------------------------------
30
HHSearch
79.16
16%
-94
- C6 -
2VSQ
2
A:
[467-957]
------------------------------------------------------
T
Y
W
F
K
E
A
V
N
A
N
P
D
A
P
A
L
T
Y
----
S
------
G
-----
Q
T
L
S
Y
R
E
--------
L
D
E
E
A
N
-----------------
R
I
A
R
R
L
Q
K
H
-
G
A
G
K
G
S
V
V
------
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
AAA
C
L
L
T
H
QEMKEQAAELPYT
G
T
T
L
F
IDDQTRFEEQASDPA-------------------------------
T
A
I
D
P
N
D
P
------------
A
------------------------------------
Y
I
M
Y
T
S
G
T
T
G
---
K
P
K
G
N
I
T
T
H
A
N
I
Q
G
L
V
K
-
H
-
V
--
D
----
Y
--
M
A
F
--
S
D
Q
D
T
F
L
S
V
S
N
Y
A
F
D
A
F
T
-
F
--
D
-
F
Y
A
S
M
L
N
A
A
R
L
I
I
---
A
D
-
E
HTL-
L
--
D
T
E
R
L
T
D
L
I
L
---
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
N
L
L
---
T
D
A
G
E
-----
D
-----
W
M
----
K
G
L
---
R
C
I
L
F
-
G
G
E
R
A
S
V
P
H
V
R
K
A
L
R
I
M
G
--
P
G
K
L
I
N
C
Y
G
P
T
E
--
G
T
---
V
--
F
-
A
T
-
A
-
H
V
V
--
H
D
LP-
D
--
S
I
S
S
L
P
I
G
K
P
I
S
N
-
A
S
V
Y
-----------
I
---------------------------------
L
---
N
EQSQLQPFGAV--
G
E
L
C
I
S
-----
G
M
--
G
V
S
K
G
------
Y
VNR
A
D
L
T
K
E
K
F
IENPFKPG
E
T
L
----------------
Y
R
T
G
D
L
A
R
-
W
L
P------------------------------------
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
-
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
H
E
-
S
G
D
A
S
I
N
A
Y
L
V
------
N
R
T
Q
---------
L
S
--
A
E
D
V
K
A
----
H
L
K
-
K
Q
-
L
P
A
Y
M
-
V
P
-
Q
T
F
T
F
L
D
E
------
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
--------------------------------------------------------------------------------
42
HHSearch
78.61
15%
-95
- C6 -
2V7B
1
?
A:
[27-528]
-------------------------------------------------------
A
Y
L
F
R
L
N
E
T
R
A
G
K
T
A
Y
I
D
----
D
------
T
-----
G
S
T
T
Y
G
E
--------
L
E
E
R
A
R
-----------------
R
F
A
S
A
L
R
T
L
-
G
V
H
P
E
E
R
I
------
L
L
V
M
L
D
T
V
A
L
P
V
A
F
L
G
A
L
Y
A
G
V
V
P
V
V
A
N
T
L
L
T
P
A
D
Y
V
Y
M
L
T
H
S
HAR
A
V
I
A
S
GAL
V
Q
N
V
T
Q
A
L
E
S
AG
C
Q
L
I
V
S
QPLAPL
F
E
E
L
I
D
A
AAPAAKA-----------------------
A
A
T
G
C
D
D
I
------------
A
------------------------------------
F
W
L
Y
S
--------
K
P
K
G
T
V
H
T
H
A
N
L
Y
W
T
A
E
-
L
-
Y
A
K
P
----
I
--
L
G
I
--
A
E
N
D
V
V
F
S
A
A
K
L
F
F
A
Y
G
L
-
G
N
-
G
-
L
T
F
P
L
S
V
G
A
T
A
I
L
---
M
A
E
R
----
P
--
T
A
D
A
I
F
A
R
L
V
---
E
H
R
P
T
V
F
Y
G
V
P
T
L
Y
A
N
M
---
L
V
S
P
N
-----
L
PAR--
A
D
----
V
A
I
---
R
I
C
T
S
-
A
G
E
A
L
P
R
E
I
G
E
R
F
T
A
H
F
---
G
C
E
I
L
D
G
I
G
S
T
E
--
M
L
---
H
--
I
-
F
L
-
S
-
N
R
A
--
G
-------
A
V
E
Y
G
T
T
G
R
P
V
P
G
-
Y
E
I
E
-----------
L
---------------------------------
R
---
D
EAGHAVPDG
E
V
--
G
D
L
Y
I
K
-----
G
P
--
S
A
A
V
M
------
Y
WNN
R
E
K
S
R
A
T
FL-------
G
E
W
----------------
I
R
S
G
D
K
Y
C
-
R
L
P------------------------------------
N
G
C
Y
V
Y
A
G
R
S
D
D
M
L
K
----
Y
V
S
P
V
E
V
E
M
V
L
-
V
Q
H
D
A
V
L
E
A
A
V
V
G
V
D
H
G
-
G
-
L
V
K
T
R
A
F
V
V
------
L
K
R
E
F
A
P
S
E
----
I
L
--
A
E
E
L
K
A
----
F
V
K
-
D
R
-
L
A
P
H
K
-
Y
P
-
R
D
I
V
F
V
D
D
------
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
E
-----------------------------------------------------------------------------------
47
Fugue
78.01
17%
-99
- C6 -
1AMU
4
GRSA_ANEMI
A:
[17-530]
GTH
E
E
E
Q
Y
L
F
A
V
N
NT
K
A
E
Y
PRDKT
I
H
Q
L
F
E
E
Q
V
S
K
RPNNVAIVCEN
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
E
K
-
G
I
G
K
----
D
------
T
-----
L
V
G
I
M
M
E
KS
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
IEYP
K
E
R
I
Q
Y
I
-------
L
D
D
S
Q
A
R
M
------
L
L
T
Q
K
H
L
V
H
L
I
H
N
I
--
Q
F
N
--
G
Q
V
E
I
F
E
E
D
-----------
T
-------------------------------------------------------------------------
I
K
I
R
----EGTNLHVPSKST
D
------------------------------------
L
A
Y
V
I
Y
T
S
P
K
---
G
T
M
L
E
H
K
G
I
S
N
L
K
V
F
F
E
-
N
----
S
----
L
--
N
-
V
--
T
E
K
D
R
I
G
Q
F
A
S
I
S
F
D
A
S
V
-
W
--
E
-
M
F
M
A
L
L
T
G
A
S
L
Y
I
I
L
K
D
T
-
I
----
N
--
D
F
V
K
F
E
Q
Y
I
N
---
Q
K
E
I
T
V
I
T
L
P
P
T
Y
V
V
H
L
-------
D
-----
P
-----
E
R
----
I
--LSI
Q
T
L
I
T
-
A
G
S
A
T
S
P
S
L
V
N
K
W
K
E
K
V
-----
T
Y
I
N
A
Y
G
P
T
E
--
T
T
---
I
CA
T
-
T
W
-
V
-
A
T
K
--
E
----
T
--
I
G
H
S
V
P
I
G
A
P
I
Q
N
-
T
Q
I
Y
-----------
I
V
D
ENLQLKSVG----------------------
E
---
A
-------------
G
E
L
C
I
G
-----
G
E
--
G
L
A
R
G
YWKR
P
E
L
-------------------
T
S
Q
K
F
VDNPFVPG
E
K
L
---
Y
K
T
G
D
Q
A
R
-
W
L
S------------------------------------
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
-
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
D
H
-
Q
E
Q
P
Y
L
C
A
Y
F
V
------
S
E
-----------
K
H
IP
L
E
Q
L
R
Q
----
F
S
S
-
E
E
-
L
P
T
Y
M
-
I
P
S-
Y
F
I
Q
L
D
K
------
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
P
D
L
TF------------------------------------------------------------------------------
18
PsiBlast_PDB
75.05
21%
-73
- C6 -
3CW8
3
?
X:
[146-502]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
-------------------------------------------------------------------------
P
Q
R
E
P
A
Q
P
------------
A
------------------------------------
F
I
F
Y
T
S
G
T
T
G
LPK
A
A
I
I
P
Q
R
A
A
E
S
R
V
L
F
M
S
-
T
-
Q
-
V
G
----
L
--
R
H
G
--
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
-
A
--
V
-
L
V
A
A
L
A
L
D
G
T
Y
V
V
---
I
E
-
E
----
F
--
R
P
V
D
A
L
Q
L
V
Q
---
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
---
A
A
A
A
A
-----
H
-----
A
G
SSLK
L
D
S
---
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
H
L
P
--
G
E
K
V
N
I
Y
G
T
T
E
A
--
M
N
--------
S
L
-
Y
--------------
M
R
Q
P
K
T
G
T
E
M
A
P
G
-
F
F
S
E
-----------
V
---------------------------------
R
---
I
-------------
V
R
I
G
--------------
G
G
------
V
-------------------
D
E
I
----------------
V
A
N
G
E
E
G
E
-
L
I
VAASDSAFVGYLNQPEATAEKLQDGWYRTSDVAVWTP
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
-
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
--
W
G
Q
S
V
T
A
C
V
V
PRLGET
L
S
A
D
---------
A
L
--
D
T
F
C
R
S
----
S
E
L
-
A
D
-
F
K
R
P
-----
K
R
Y
F
I
L
D
Q
------
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
---------------------------------------------------------------------------------
25
HHSearch
74.99
16%
-85
- C6 -
1PG4
7
ACSA_SALTY
A:
[80-619]
-------------------------------------------------------
N
C
L
D
R
H
L
Q
E
N
G
D
R
T
A
I
I
W
----
E
G
DDTS
Q
S
-----
K
H
I
S
Y
R
E
--------
L
H
R
D
V
C
-----------------
R
F
A
N
T
L
L
D
L
-
G
I
K
K
G
D
V
V
------
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
SSR
L
V
I
T
A
D
E
G
V
R
AG
R
S
I
P
L
K
K
N
V
D
D
A
L
K
NPNVTSVE
H
V
I
V
L
KRTG
S
D
I
D
W
Q
E
GRDLW
W
R
D
L
I
E
K
ASP
E
H
Q
P
E
A
M
N
A
E
D
P
------------
L
------------------------------------
F
I
L
Y
T
S
G
S
T
G
---
K
P
K
G
V
L
H
T
T
G
G
Y
L
V
Y
A
A
-
T
T
F
-
K
Y
----
V
--
F
D
Y
--
H
P
G
D
I
Y
W
C
T
A
D
V
G
W
V
T
G
H
S
Y
--
L
-
L
Y
G
P
L
A
C
G
A
T
T
L
M
---
F
E
-
G
VPNW
P
--
T
P
A
R
M
C
Q
V
V
D
---
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
---
M
A
E
G
D
-----
K
AIEGT
D
R
----
S
S
L
---
R
I
L
G
S
-
V
G
E
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
G
KE
K
C
P
V
V
D
T
W
W
Q
T
E
--
T
G
---
G
--
F
-
M
I
T
P
-
L
P
G
--
A
----
I
--
E
L
K
A
G
S
A
T
R
P
F
F
G
-
V
Q
P
A
-----------
L
---------------------------------
V
---
D
NEG
H
P
Q
E
G
ATE--
G
N
L
V
I
T
-----
D
S
WP
G
Q
A
R
T
------
L
FGD
H
E
R
F
E
Q
T
YFSTF----
K
N
M
----------------
Y
F
S
G
D
G
A
R
-
R
D
E------------------------------------
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
-
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
-
I
K
G
Q
A
I
Y
A
Y
V
T
------
L
N
H
G
E
E
P
S
P
----
E
L
--
Y
A
E
V
R
N
----
W
V
R
-
K
E
-
I
G
P
L
A
-
T
P
-
D
V
L
H
W
T
D
S
------
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
A
A
--------------------------------------------------------------------------------