@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0544: (2015-12-01 )
MVTIEKIDEAIHRYYKQTHSVVSPDLIKAILYSVDGGGKRIRPRILLEILEGFGVELIDGHYDVAAALEMIHTGSLIHDDLPAMDNDDFRRGRLTNHKKFDEATAVLAGDSLFLDPFDLVVKAGFKADVTVRLIELLSMSAGSFGMVGGQMLDMKGENKVLSIDDLSLIHINKTGRLLAYPFVAAGILAEKSEEVKGKLHQAGLLIGHAFQVRDDILDVTASFEELGKTPNKDIVAEKTTYPNLLGLDKSQEILDDTLKKAQAIFQNLEKKANFNARKIIDIIEGLRLNG
Atome Classification :
(42 SA)
.........10........20----...--......30........40........50-----......--..-.60---...-......70........80........90........100.......110.......120.--...---..---.130----....--...140.......150.-.....---.160........170.......180---........-190.-......200.......210.......220.......230.......240......----.250-------....---....260......-.270.-..-.....280........290
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MV
T
I
E
K
I
D
E
A
I
H
R
Y
Y
K
Q
THS-----VV
S
--
P
D
L
I
K
A
I
L
Y
SVDGGGKR
I
R
P
R
I
L
L
E
I
L
------
E
GFG
V
E
--LI-DG----H
Y
D
-
V
A
A
A
L
E
M
I
HTGSLIHDDLPAMDNDDFRRGRLTN
H
K
K
F
D
E
A
T
A
V
LAGDSLFL
D
P
F
D
L
V
V
KA--GFK---A
D
---
V
T
V
R
----
L
I
E
L
--
L
SMSAGSFGMVG
G
Q
M
LD-MKGEN---
K
V
-
L
S
ID
D
L
S
L
I
H
INKTG
R
L
L
A
Y
P
----
F
V
A
A
G
I
LA-E
K
S
E
-
E
V
K
G
K
L
H
Q
A
G
L
L
I
G
H
A
F
Q
V
R
D
D
I
L
D
V
T
A
S
F
E
E
LGKTPNKDIVAEKTTYPNLLGLD----
K
S
Q
--------
E
I
L
D
---
D
T
L
K
K
A
Q
A
I
F
Q
N
L
-
E
K
-KA-NF-
N
A
R
K
I
I
D
-
I
I
E
G
LRLNG
1
PsiBlast_PDB
94.14
57%
-95
- C1 -
4LFE
3
?
A:
[2-290]
M
D
K
L
K
K
I
D
Q
T
I
H
A
F
Y
C
E
K
-
A
-----
V
I
S
--
E
K
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
I
------
E
A
L
Q
I
P
--
L
T
-
E
S
----
H
F
K
-
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
M
L
A
E
T
--
D
F
P
---
T
D
---
V
T
V
D
----
L
V
R
S
--
L
S
S
A
S
G
T
F
G
M
V
G
G
Q
M
L
D
-
M
A
A
E
G
---
K
K
-
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
----
F
W
A
A
A
R
V
A
-
Q
L
D
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
----------------
K
M
T
Y
P
H
L
L
G
L
N
----
E
S
Y
--------
Q
I
L
D
---
E
S
L
D
Q
A
E
A
I
L
R
K
L
-
S
D
-
E
I
-
A
F
-
A
P
Q
K
I
L
S
-
L
I
E
R
L
R
L
D
A
2
PsiBlast_PDB
92.16
57%
-83
- C1 -
4LFG
5
?
A:
[2-290]
M
D
K
L
K
K
I
D
Q
T
I
H
A
F
Y
C
E
K
-
A
-----
V
I
S
--
E
K
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
I
------
E
A
L
Q
I
P
--
L
T
-
E
S
----
H
F
K
-
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
M
L
A
E
T
--
D
F
P
---
T
D
---
V
T
V
D
----
L
V
R
S
--
L
S
S
A
S
G
T
F
G
M
V
G
G
Q
M
L
D
-
M
A
A
E
G
---
K
K
-
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
----
F
W
A
A
A
R
V
A
-
Q
L
D
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
----
E
S
Y
--------
Q
I
L
D
---
E
S
L
D
Q
A
E
A
I
L
R
K
L
-
S
D
-
E
I
-
A
F
-
A
P
Q
K
I
L
S
-
L
I
E
R
L
R
L
D
A
21
PsiBlast_CBE
92.08
57%
-83
- C1 -
4LFG
5
?
B:
[3-290]
-
D
K
L
K
K
I
D
Q
T
I
H
A
F
Y
C
E
K
-
A
-----
V
I
S
--
E
K
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
I
------
E
A
L
Q
I
P
--
L
T
-
E
S
----
H
F
K
-
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
M
L
A
E
T
--
D
F
P
---
T
D
---
V
T
V
D
----
L
V
R
S
--
L
S
S
A
S
G
T
F
G
M
V
G
G
Q
M
L
D
-
M
A
A
E
G
---
K
K
-
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
----
F
W
A
A
A
R
V
A
-
Q
L
D
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
----
E
S
Y
--------
Q
I
L
D
---
E
S
L
D
Q
A
E
A
I
L
R
K
L
-
S
D
-
E
I
-
A
F
-
A
P
Q
K
I
L
S
-
L
I
E
R
L
R
L
D
A
22
PsiBlast_CBE
91.15
57%
-82
- C1 -
4LFE
5
?
B:
[3-290]
-
D
K
L
K
K
I
D
Q
T
I
H
A
F
Y
C
E
K
-
A
-----
V
I
S
--
E
K
L
N
E
A
V
L
Y
S
I
N
A
G
G
K
R
I
R
P
I
L
F
L
E
V
I
------
E
A
L
Q
I
P
--
L
T
-
E
S
----
H
F
K
-
A
A
A
A
L
E
M
I
H
T
G
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
Q
L
T
N
H
K
K
F
D
E
A
T
A
I
L
A
G
D
S
L
F
L
D
A
F
G
M
L
A
E
T
--
D
F
P
---
T
D
---
V
T
V
D
----
L
V
R
S
--
L
S
S
A
S
G
T
F
G
M
V
G
G
Q
M
L
D
-
M
A
A
E
G
---
K
K
-
L
N
L
K
N
L
Q
L
I
H
R
H
K
T
G
Q
L
L
A
Y
P
----
F
W
A
A
A
R
V
A
-
Q
L
D
E
-
N
L
L
A
T
F
L
E
I
G
M
I
I
G
L
A
F
Q
V
R
D
D
I
L
D
I
T
A
N
F
E
E
I
G
K
T
P
K
K
D
V
M
A
E
K
M
T
Y
P
H
L
L
G
L
N
----
E
S
Y
--------
Q
I
L
D
---
E
S
L
D
Q
A
E
A
I
L
R
K
L
-
S
D
-
E
I
-
A
F
-
A
P
Q
K
I
L
S
-
L
I
E
R
L
R
L
D
A
85
HHSearch
80.59
41%
-91
- C1 -
3P8L
-
?
A:
[10-292]
----
P
L
V
E
K
V
M
V
D
F
I
A
E
Y
-------
T
E
N
--
E
R
L
K
E
A
M
L
Y
S
I
H
A
G
G
K
R
L
R
P
L
L
V
L
T
T
V
------
A
A
F
Q
K
E
--
M
E
-
T
Q
----
D
Y
Q
-
V
A
A
S
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
N
H
K
V
F
G
E
A
T
A
I
L
A
G
D
G
L
L
T
G
A
F
Q
L
L
S
L
S
--
Q
L
G
---
L
S
---
E
K
V
L
----
L
M
Q
Q
--
L
A
K
A
A
G
N
Q
G
M
V
S
G
Q
M
G
D
-
I
E
G
E
K
---
V
S
-
L
T
L
E
E
L
A
A
V
H
E
K
K
T
G
A
L
I
E
F
A
----
L
I
A
G
G
V
L
A
-
N
Q
T
E
-
E
V
I
G
L
L
T
Q
F
A
H
H
Y
G
L
A
F
Q
I
R
D
D
L
L
D
A
T
S
-----------------
S
T
Y
P
A
L
L
G
I
A
----
G
A
K
--------
D
A
L
T
---
H
Q
L
A
E
G
S
A
V
L
E
K
I
-
K
A
N
V
P
-
N
F
-
S
E
E
H
L
A
N
-
L
L
T
Q
L
Q
L
R
-
3
PsiBlast_PDB
75.86
43%
-91
- C1 -
3P8L
-
?
A:
[29-292]
--------------------------------
L
K
E
A
M
L
Y
S
I
H
A
G
G
K
R
L
R
P
L
L
V
L
T
T
V
------
A
A
F
Q
K
E
--
M
E
-
T
Q
----
D
Y
Q
-
V
A
A
S
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
N
H
K
V
F
G
E
A
T
A
I
L
A
G
D
G
L
L
T
G
A
F
Q
L
L
S
L
S
--
Q
L
G
---
L
S
---
E
K
V
L
----
L
M
Q
Q
--
L
A
K
A
A
G
N
Q
G
M
V
S
G
Q
M
G
D
-
I
E
G
E
K
---
V
S
-
L
T
L
E
E
L
A
A
V
H
E
K
K
T
G
A
L
I
E
F
A
----
L
I
A
G
G
V
L
A
-
N
Q
T
E
-
E
V
I
G
L
L
T
Q
F
A
H
H
Y
G
L
A
F
Q
I
R
D
D
L
L
D
A
T
S
-----------------
S
T
Y
P
A
L
L
G
I
A
----
G
A
K
--------
D
A
L
T
---
H
Q
L
A
E
G
S
A
V
L
E
K
I
-
K
A
-
N
V
P
N
F
-
S
E
E
H
L
A
N
-
L
L
T
Q
L
Q
L
R
-
81
HHSearch
74.46
38%
-97
- C1 -
1RTR
-
?
A:
[10-288]
---
I
D
E
V
N
N
E
L
S
V
A
-
I
N
K
S
------
V
M
D
--
T
Q
L
E
E
S
M
L
Y
S
L
N
A
G
G
K
R
I
R
P
V
L
L
L
L
T
L
------
D
S
L
N
T
E
--
Y
--
E
L
----
G
M
K
-
S
A
I
A
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
K
L
T
N
H
K
V
Y
G
E
W
T
A
I
L
A
G
D
A
L
L
T
K
A
F
E
L
I
S
S
D
--
D
R
L
T--
D
E
---
V
K
I
K
----
V
L
Q
R
--
L
S
I
A
S
G
H
V
G
M
V
G
G
Q
M
L
D
-
M
Q
S
E
G
---
Q
P
-
I
D
L
E
T
L
E
M
I
H
K
T
K
T
G
A
L
L
T
F
A
----
V
M
S
A
A
D
I
A
-
N
V
D
D
-
T
T
K
E
H
L
E
S
Y
S
Y
H
L
G
M
M
F
Q
I
K
D
D
L
L
D
C
Y
G
D
E
A
-------------
K
S
T
Y
V
S
L
L
G
K
D
----
G
A
E
--------
D
K
L
T
---
Y
H
R
D
A
A
V
D
E
L
T
Q
I
-
D
E
-
Q
F
-
N
T
---
K
H
L
L
E
-
I
V
D
L
F
Y
S
R
-
12
PsiBlast_PDB
71.92
39%
-81
- C1 -
3NPK
2
?
A:
[10-283]
----------
I
H
H
L
E
K
N
L
P
K
-----
V
E
S
FH
P
F
F
N
E
A
L
A
L
M
L
K
A
G
G
K
H
F
R
A
Q
L
L
L
S
V
V
------
Q
S
N
K
P
E
--
L
L
-
N
Q
----
A
L
D
-
V
A
L
A
L
E
F
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
A
D
F
R
R
G
I
P
T
L
H
K
S
Y
D
E
T
T
A
I
L
V
G
D
A
L
N
T
E
A
F
L
V
L
S
H
A
--
H
L
K
---
D
E
---
I
K
I
K
----
L
I
K
T
--
L
A
F
N
A
G
L
N
G
M
V
I
G
Q
A
I
D
-
C
F
F
E
D
---
K
R
-
L
S
L
N
E
L
E
F
L
H
T
H
K
T
A
R
L
I
A
A
A
----
L
K
M
G
C
E
I
C
-
E
L
N
N
-
E
E
S
N
Q
I
Y
K
L
G
L
K
L
G
L
I
F
Q
I
N
D
D
I
I
D
V
T
------------------
N
S
F
V
N
L
L
G
L
E
----
Q
A
I
--------
K
T
K
E
---
N
L
L
N
E
C
E
Q
D
L
E
K
L
N
E
K
-
L
A
-
Q
M
-
I
Q
N
L
I
I
Q
-
Y
L
-------
77
HHSearch
69.96
39%
-73
* C1 *
3PDE
5
?
A:
[17-285]
----
P
A
L
N
A
P
L
K
Q
A
-
I
L
A
D
------
S
Q
D
--
A
Q
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
------
Q
S
L
G
V
T
F
V
P
--
E
R
----
H
W
R
-
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
--
D
L
P
---
A
T
---
M
Q
A
A
----
L
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
-
I
Q
S
E
H
---
V
N
-
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
----
V
Q
A
G
L
I
L
G
-
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
----
G
A
N
--------
Q
A
L
I
---
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
T
-
S
T
-
Q
R
-
D
D
L
A
A
F
F
-
S
Y
F
D
T
E
R
V
N
84
HHSearch
69.24
37%
-77
- C1 -
3LSN
3
?
A:
[11-281]
---
Q
A
R
V
D
A
A
M
H
T
L
F
-
T
A
P
S
-----
P
E
L
--
A
R
L
Y
E
A
M
R
Y
S
V
M
N
G
G
K
R
V
R
P
L
L
A
Y
A
A
C
------
E
A
L
G
G
K
--
P
--
E
Q
----
A
N
G
-
A
A
C
A
V
E
L
I
H
A
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
T
H
K
A
F
D
E
A
C
A
I
L
A
G
D
G
L
Q
S
L
A
F
S
A
L
L
D
P
--
A
L
S
DAS
A
E
---
I
R
L
R
----
M
V
T
T
--
L
A
Q
A
A
G
P
A
G
M
V
G
G
Q
A
I
D
-
L
G
S
V
G
---
L
K
-
L
D
Q
Q
A
L
E
Y
M
H
R
H
K
T
G
A
L
I
E
A
S
----
V
I
L
G
A
L
A
S
-
G
R
A
E
K
G
E
L
K
A
L
Q
T
Y
A
Q
A
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
E
S
D
T
A
T
L
------------
P
T
Y
P
A
L
L
G
L
A
----
A
A
K
--------
E
Y
A
L
---
E
L
R
D
Q
A
L
H
A
L
R
P
F
-
D
A
-
A
A
-
E
P
-
L
R
E
L
A
R
Y
-
I
V
E
------
88
HHSearch
66.89
38%
-80
- C1 -
3NPK
2
?
A:
[5-270]
--
L
K
E
L
F
I
H
H
L
E
K
N
L
P
K
V
E
------
S
F
H
--
P
F
F
N
E
A
L
A
L
M
L
K
A
G
G
K
H
F
R
A
Q
L
L
L
S
V
V
------
Q
S
N
K
P
E
--
L
L
-
N
Q
----
A
L
D
-
V
A
L
A
L
E
F
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
A
D
F
R
R
G
I
P
T
L
H
K
S
Y
D
E
T
T
A
I
L
V
G
D
A
L
N
T
E
A
F
L
V
L
S
H
A
--
H
L
K
---
D
E
---
I
K
I
K
----
L
I
K
T
L
A
F
N
A
G
L
--
N
G
M
V
I
G
Q
A
I
D
-
C
F
F
E
D
---
K
R
-
L
S
L
N
E
L
E
F
L
H
T
H
K
T
A
R
L
I
A
A
A
----
L
K
M
G
C
E
I
C
-
E
L
N
N
-
E
E
S
N
Q
I
Y
K
L
G
L
K
L
G
L
I
F
Q
I
N
D
D
I
I
D
V
T
------------------
N
S
F
V
N
L
L
G
L
E
----
Q
A
I
--------
K
T
K
E
---
N
L
L
N
E
C
E
Q
D
L
E
K
L
-
N
E
-
K
L
-
A
Q
-
M
I
Q
N
L
I
I
-
Q
Y
L
------
4
PsiBlast_PDB
65.76
41%
-83
- C1 -
1RTR
-
?
A:
[24-286]
-------------------
S
-----
V
M
D
--
T
Q
L
E
E
S
M
L
Y
S
L
N
A
G
G
K
R
I
R
P
V
L
L
L
L
T
L
------
D
S
L
N
T
E
--
Y
E
-
L
G
-----
M
K
-
S
A
I
A
L
E
M
I
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
D
Y
R
R
G
K
L
T
N
H
K
V
Y
G
E
W
T
A
I
L
A
G
D
A
L
L
T
K
A
F
E
L
I
S
S
D
--
D
R
L
---
T
D
E
--
V
K
I
K
----
V
L
Q
R
--
L
S
I
A
S
G
H
V
G
M
V
G
G
Q
M
L
D
-
M
Q
S
E
G
---
Q
P
-
I
D
L
E
T
L
E
M
I
H
K
T
K
T
G
A
L
L
T
F
A
----
V
M
S
A
A
D
I
A
-
N
V
D
D
-
T
T
K
E
H
L
E
S
Y
S
Y
H
L
G
M
M
F
Q
I
K
D
D
L
L
D
C
Y
G
D
E
A
-------------
K
S
T
Y
V
S
L
L
G
K
D
----
G
A
E
--------
D
K
L
-----
T
Y
H
R
D
A
A
V
D
E
L
T
-
Q
I
-
D
E
-
Q
F
-
N
T
K
H
L
L
E
-
I
V
D
L
F
Y
S
R
-
79
HHSearch
65.56
38%
-78
- C1 -
3TS7
2
?
A:
[17-289]
---
Q
E
R
V
E
R
A
L
D
A
R
L
P
A
A
D
------
R
M
P
--
E
R
L
H
Q
A
M
R
Y
S
V
L
G
G
G
K
R
M
R
P
L
L
T
Y
A
T
G
------
Q
T
I
G
V
A
--
A
--
D
L
----
L
D
G
-
P
A
C
A
V
E
F
I
H
V
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
K
P
T
C
H
K
A
Y
D
E
A
T
A
I
L
A
G
D
G
L
Q
A
L
A
F
H
V
L
A
Q
D
--
P
S
I
AVP
A
E
---
N
R
I
A
----
M
I
E
T
--
L
A
K
A
S
G
P
A
G
M
V
G
G
Q
A
I
D
-
L
A
S
V
G
---
K
K
-
L
D
L
P
G
L
E
N
M
H
I
R
K
T
G
A
L
I
R
A
S
----
V
R
L
A
C
L
A
R
P
G
L
P
A
-
E
Q
F
D
R
L
D
H
Y
A
K
C
I
G
L
A
F
Q
I
Q
D
D
I
L
D
E
E
S
D
---------------
K
P
N
Y
P
A
L
L
G
L
S
----
G
A
K
--------
E
K
A
E
---
E
M
H
E
A
A
L
E
S
L
A
G
F
-
G
P
-
E
A
-
D
L
-
L
R
E
L
A
R
F
-
I
I
Q
R
Q
S
A
E
N
78
HHSearch
64.91
36%
-74
- C1 -
2H8O
-
?
A:
[47-322]
---
A
A
K
T
E
A
L
L
G
H
L
-
L
S
G
E
A
RADEI
T
R
P
--
Q
N
L
L
E
A
M
R
H
G
V
L
N
G
G
K
R
L
R
P
F
L
V
I
E
S
V
------
A
L
L
G
G
D
--
A
--
E
A
----
G
L
H
-
V
G
A
A
L
E
C
L
H
C
Y
S
L
V
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
Q
P
T
V
H
R
K
F
D
E
A
T
A
I
L
A
G
D
S
L
L
T
L
A
F
D
I
I
A
S
D
--
D
N
P
LA-
A
E
---
R
K
A
A
----
L
V
I
S
--
L
A
R
A
A
G
I
G
G
M
A
G
G
Q
A
L
D
-
L
A
A
E
K
---
K
A
-
P
D
E
D
G
I
I
T
L
Q
A
M
K
T
G
A
L
L
R
F
A
----
C
E
A
G
A
I
I
A
-
G
S
N
Q
-
A
E
R
Q
R
L
R
L
F
G
E
K
I
G
L
S
F
Q
L
A
D
D
L
L
D
L
T
-----------------
K
G
T
L
V
A
L
R
G
E
A
----
W
A
R
--------
E
K
L
Q
---
E
Q
V
A
E
A
S
E
L
L
A
P
Y
-
G
E
-
K
A
-
A
I
-
L
I
A
A
A
R
F
-
I
A
E
------
14
PsiBlast_PDB
64.50
42%
-83
- C1 -
3PDE
5
?
A:
[36-279]
--------------------------------
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
------
Q
S
L
G
V
T
--
F
V
P
E
R
----
H
W
R
-
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
--
D
L
P
---
A
T
---
M
Q
A
A
----
L
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
-
I
Q
S
E
H
---
V
N
-
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
----
V
Q
A
G
L
I
L
G
-
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
-----------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
----
G
A
N
--------
Q
A
L
I
---
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
T
-
S
T
-
Q
R
-
D
D
L
A
A
F
F
-
S
Y
F
D
T
E
R
V
N
46
PsiBlast_CBE
64.15
36%
-65
- C1 -
1RQJ
5
ISPA_ECOLI
B:
[9-281]
-
A
C
V
K
Q
A
N
Q
A
L
S
R
F
I
A
P
L
P
F
-----
Q
N
T
--
P
-
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
------
H
M
F
G
V
S
TN
T
L
-
D
A
----
P
----
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
--
D
M
P
----
E
---
V
S
D
R
D
R
I
S
M
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
-
L
D
A
E
G
---
K
H
-
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
----
V
R
L
G
A
L
S
A
G
D
K
G
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
----
Q
A
R
--------
K
K
A
R
---
D
L
I
D
D
A
R
Q
S
L
K
Q
L
-
A
E
-
Q
S
-
L
D
-
T
S
A
L
E
A
L
-
A
D
Y
I
I
Q
R
N
K
30
PsiBlast_CBE
64.00
42%
-83
- C1 -
3PDE
4
?
D:
[36-279]
--------------------------------
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
------
Q
S
L
G
V
T
--
F
V
P
E
R
----
H
W
R
-
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
--
D
L
P
---
A
T
---
M
Q
A
A
----
L
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
-
I
Q
S
E
H
---
V
N
-
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
----
V
Q
A
G
L
I
L
G
-
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
P
A
---------
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
----
G
A
N
--------
Q
A
L
I
---
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
T
-
S
T
-
Q
R
-
D
D
L
A
A
F
F
-
S
Y
F
D
T
E
R
V
N
49
PsiBlast_CBE
63.98
36%
-66
- C1 -
1RQI
6
ISPA_ECOLI
A:
[10-282]
-
A
C
V
K
Q
A
N
Q
A
L
S
R
F
I
A
P
L
P
F
-----
Q
N
T
--
P
-
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
------
H
M
F
G
V
S
TN
T
L
-
D
A
----
P
----
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
--
D
M
P
----
E
---
V
S
D
R
D
R
I
S
M
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
-
L
D
A
E
G
---
K
H
-
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
----
V
R
L
G
A
L
S
A
G
D
K
G
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
----
Q
A
R
--------
K
K
A
R
---
D
L
I
D
D
A
R
Q
S
L
K
Q
L
-
A
E
-
Q
S
-
L
D
-
T
S
A
L
E
A
L
-
A
D
Y
I
I
Q
R
N
K
44
PsiBlast_CBE
63.77
36%
-81
- C1 -
2FOR
2
?
B:
[33-305]
-
A
C
V
K
Q
A
N
Q
A
L
S
R
F
I
A
P
L
P
F
-----
Q
N
T
--
P
-
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
------
H
M
F
G
V
S
TN
T
L
-
D
A
----
P
----
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
--
N
M
P
----
E
---
V
S
D
R
D
R
I
S
M
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
-
L
D
A
E
G
---
K
H
-
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
----
V
R
L
G
A
L
S
A
G
D
K
G
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
-----------------
K
S
T
Y
P
A
L
L
G
L
E
----
Q
A
R
--------
K
K
A
R
---
D
L
I
D
D
A
R
Q
A
L
K
Q
L
-
A
E
-
Q
S
-
L
D
-
T
S
A
L
E
A
L
-
A
D
Y
I
I
Q
R
N
-
13
PsiBlast_PDB
63.74
42%
-81
- C1 -
3M9U
6
?
A:
[36-279]
--------------------------------
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
------
Q
S
L
G
V
T
--
F
V
P
E
R
----
H
W
R
-
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
--
D
L
P
---
A
T
---
M
Q
A
A
----
L
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
-
I
Q
S
E
H
---
V
N
-
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
----
V
Q
A
G
L
I
L
G
-
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
------------
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
----
G
A
N
--------
Q
A
L
I
---
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
T
-
S
T
-
Q
R
-
D
D
L
A
A
F
F
-
S
Y
F
D
T
E
R
V
N
47
PsiBlast_CBE
63.67
36%
-66
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[9-281]
-
A
C
V
K
Q
A
N
Q
A
L
S
R
F
I
A
P
L
P
F
-----
Q
N
T
--
P
-
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
------
H
M
F
G
V
S
TN
T
L
-
D
A
----
P
----
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
--
D
M
P
----
E
---
V
S
D
R
D
R
I
S
M
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
-
L
D
A
E
G
---
K
H
-
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
----
V
R
L
G
A
L
S
A
G
D
K
G
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
----
Q
A
R
--------
K
K
A
R
---
D
L
I
D
D
A
R
Q
S
L
K
Q
L
-
A
E
-
Q
S
-
L
D
-
T
S
A
L
E
A
L
-
A
D
Y
I
I
Q
R
N
K
33
PsiBlast_CBE
63.51
42%
-85
- C1 -
3M9U
6
?
C:
[36-279]
--------------------------------
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
------
Q
S
L
G
V
T
--
F
V
P
E
R
----
H
W
R
-
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
--
D
L
P
---
A
T
---
M
Q
A
A
----
L
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
-
I
Q
S
E
H
---
V
N
-
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
----
V
Q
A
G
L
I
L
G
-
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
S
--------------
A
K
N
T
Y
P
G
K
L
G
L
I
----
G
A
N
--------
Q
A
L
I
---
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
T
-
S
T
-
Q
R
-
D
D
L
A
A
F
F
-
S
Y
F
D
T
E
R
--
31
PsiBlast_CBE
62.81
42%
-83
- C1 -
3PDE
5
?
C:
[36-279]
--------------------------------
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
------
Q
S
L
G
V
T
--
F
V
P
E
R
----
H
W
R
-
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
--
D
L
P
---
A
T
---
M
Q
A
A
----
L
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
-
I
Q
S
E
H
---
V
N
-
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
----
V
Q
A
G
L
I
L
G
-
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
----------------
K
N
T
Y
P
G
K
L
G
L
I
----
G
A
N
--------
Q
A
L
I
---
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
T
-
S
T
-
Q
R
-
D
D
L
A
A
F
F
-
S
Y
F
D
T
E
R
--
92
HHSearch
62.73
39%
-77
- C1 -
2J1P
2
GGPPS_SINAL
A:
[21-277]
---
A
D
S
V
N
K
A
L
D
S
A
-
V
P
L
-------
R
E
P
--
L
K
I
H
E
A
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
V
L
C
I
A
A
C
------
E
L
V
G
G
E
--
E
--
S
L
----
A
M
P
-
A
A
C
A
V
E
M
I
H
T
M
S
L
I
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
K
V
Y
G
E
D
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
L
A
S
A
--
T
S
S
EVS
P
A
---
R
V
V
R
----
A
V
G
E
--
L
A
K
A
I
G
T
E
G
L
V
A
G
Q
V
V
D
-
I
S
---LDL
N
N
-
V
G
L
E
H
L
K
F
I
H
L
H
K
T
A
A
L
L
E
A
S
----
A
V
L
G
G
I
I
G
-
G
G
S
D
-
E
E
I
E
R
L
R
K
F
A
R
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
----------------
K
L
T
Y
P
K
L
M
G
L
E
----
K
S
R
--------
E
F
A
E
---
K
L
N
T
E
A
R
D
Q
L
L
G
F
-
D
S
-
D
K
-
V
A
-
P
L
L
A
L
A
N
-
Y
I
A
N
R
Q
N
--
48
PsiBlast_CBE
62.48
36%
-66
- C1 -
1RQI
5
ISPA_ECOLI
B:
[10-282]
-
A
C
V
K
Q
A
N
Q
A
L
S
R
F
I
A
P
L
P
F
-----
Q
N
T
--
P
-
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
------
H
M
F
G
V
S
TN
T
L
-
D
A
----
P
----
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
--
D
M
P
----
E
---
V
S
D
R
D
R
I
S
M
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
-
L
D
A
E
G
---
K
H
-
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
----
V
R
L
G
A
L
S
A
G
D
K
G
R
-
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
----
Q
A
R
--------
K
K
A
R
---
D
L
I
D
D
A
R
Q
S
L
K
Q
L
-
A
E
-
Q
S
-
L
D
-
T
S
A
L
E
A
L
-
A
D
Y
I
I
Q
R
N
K
82
HHSearch
61.51
36%
-63
- C1 -
1RQJ
5
ISPA_ECOLI
A:
[11-280]
---
V
K
Q
A
N
Q
A
L
S
R
F
I
A
P
L
P
------
F
Q
N
--
T
P
V
V
E
T
M
Q
Y
G
A
L
L
G
G
K
R
L
R
P
F
L
V
Y
A
T
G
------
H
M
F
G
V
S
--
T
--
N
T
----
L
D
A
-
P
A
A
A
V
E
C
I
H
A
Y
S
L
I
H
D
D
L
P
A
M
D
D
D
D
L
R
R
G
L
P
T
C
H
V
K
F
G
E
A
N
A
I
L
A
G
D
A
L
Q
T
L
A
F
S
I
L
S
D
A
--
D
M
P
---
E
V
S
D
R
D
R
I
S
----
M
I
S
E
--
L
A
S
A
S
G
I
A
G
M
C
G
G
Q
A
L
D
-
L
D
A
E
G
---
K
H
-
V
P
L
D
A
L
E
R
I
H
R
H
K
T
G
A
L
I
R
A
A
----
V
R
L
G
A
L
S
A
-
G
D
K
G
R
R
A
L
P
V
L
D
K
Y
A
E
S
I
G
L
A
F
Q
V
Q
D
D
I
L
D
V
V
G
D
T
A
T
L
G
K
R
Q
G
A
D
Q
Q
L
G
K
S
T
Y
P
A
L
L
G
L
E
----
Q
A
R
--------
K
K
A
R
---
D
L
I
D
D
A
R
Q
S
L
K
Q
L
-
A
E
-
Q
S
-
L
D
-
T
S
A
L
E
A
L
-
A
D
Y
I
I
Q
R
N
K
32
PsiBlast_CBE
60.30
42%
-81
- C1 -
3PDE
4
?
B:
[36-279]
--------------------------------
L
A
A
A
M
T
Y
S
V
L
A
G
G
K
R
L
R
P
L
L
T
V
A
T
M
------
Q
S
L
G
V
T
--
F
V
P
E
R
----
H
W
R
-
P
V
M
A
L
E
L
L
H
T
Y
S
L
I
H
D
D
L
P
A
M
D
N
D
A
L
R
R
G
E
P
T
N
H
V
K
F
G
A
G
M
A
T
L
A
G
D
G
L
L
T
L
A
F
Q
W
L
T
A
T
--
D
L
P
---
A
T
---
M
Q
A
A
----
L
V
Q
A
--
L
A
T
A
A
G
P
S
G
M
V
A
G
Q
A
K
D
-
I
Q
S
E
H
---
V
N
-
L
P
L
S
Q
L
R
V
L
H
K
E
K
T
G
A
L
L
H
Y
A
----
V
Q
A
G
L
I
L
G
-
Q
A
P
E
-
A
Q
W
P
A
Y
L
Q
F
A
D
A
F
G
L
A
F
Q
I
Y
D
D
I
L
D
V
V
S
-----------
D
A
D
E
A
K
N
T
Y
P
G
K
L
G
L
I
----
G
A
N
--------
Q
A
L
I
---
D
T
I
H
S
G
Q
A
A
L
Q
G
L
-
P
T
-
S
T
-
Q
R
-
D
D
L
A
A
F
F
-
S
Y
F
D
T
E
R
--
42
PsiBlast_CBE
58.68
36%
-43
- C1 -
4LLS
6
?
B:
[35-309]
----------
V
Q
A
H
F
D
K
V
L
A
-----
A
F
E
--
P
L
P
I
V
E
A
M
A
H
A
T
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
------
R
L
H
D
I
A
--
A
G
-
E
A
----
I
W
S
--
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
H
P
--
G
A
S
---
A
S
---
A
E
V
R
A
D
--
L
A
L
S
--
L
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
-
I
A
A
E
T
AR-
A
P
-
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
----
A
Q
A
G
A
R
L
A
-
Q
A
D
T
-
A
A
L
K
R
Y
A
Q
A
---
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
--------
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
K
A
D
T
L
-
R
E
-
T
A
-
R
F
-
V
V
R
R
T
H
-----------
18
PsiBlast_PDB
58.14
36%
-43
- C1 -
4LLS
6
?
A:
[35-309]
----------
V
Q
A
H
F
D
K
V
L
A
-----
A
F
E
--
P
L
P
I
V
E
A
M
A
H
A
T
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
------
R
L
H
D
I
A
--
A
G
-
E
A
----
I
W
S
--
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
H
P
--
G
A
S
---
A
S
---
A
E
V
R
A
D
--
L
A
L
S
--
L
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
-
I
A
A
E
T
A
R-
A
P
-
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
----
A
Q
A
G
A
R
L
A
-
Q
A
D
T
-
A
A
L
K
R
Y
A
Q
A
---
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
--------
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
K
A
D
T
L
-
R
E
-
T
A
-
R
F
-
V
V
R
R
T
H
-----------
41
PsiBlast_CBE
57.84
36%
-43
- C1 -
4LLT
5
?
B:
[35-309]
----------
V
Q
A
H
F
D
K
V
L
A
-----
A
F
E
--
P
L
P
I
V
E
A
M
A
H
A
T
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
------
R
L
H
D
I
A
--
A
G
-
E
A
----
I
W
S
--
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
H
P
--
G
A
S
---
A
S
---
A
E
V
R
A
D
--
L
A
L
S
--
L
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
-
I
A
A
E
T
AR-
A
P
-
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
----
A
Q
A
G
A
R
L
A
-
Q
A
D
T
-
A
A
L
K
R
Y
A
Q
A
---
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
--------
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
K
A
D
T
L
-
R
E
-
T
A
-
R
F
-
V
V
R
R
T
H
-----------
19
PsiBlast_PDB
56.66
36%
-42
- C1 -
4LLT
5
?
A:
[35-309]
----------
V
Q
A
H
F
D
K
V
L
A
-----
A
F
E
--
P
L
P
I
V
E
A
M
A
H
A
T
S
G
G
K
R
L
R
G
F
L
V
L
E
T
A
------
R
L
H
D
I
A
--
A
G
-
E
A
----
I
W
S
--
A
T
A
I
E
A
L
H
A
Y
S
L
V
H
D
D
L
P
C
M
D
N
D
D
M
R
R
G
Q
P
T
V
H
K
K
W
D
D
A
T
A
V
L
A
G
D
A
L
Q
T
L
A
F
E
L
V
T
H
P
--
G
A
S
---
A
S
---
A
E
V
R
A
D
--
L
A
L
S
--
L
A
R
A
S
G
A
Q
G
M
V
L
G
Q
A
L
D
-
I
A
A
E
T
A
R-
A
P
-
L
S
L
D
E
I
T
R
L
Q
Q
G
K
T
G
A
L
I
G
W
S
----
A
Q
A
G
A
R
L
A
-
Q
A
D
T
-
A
A
L
K
R
Y
A
Q
A
---
L
G
L
A
F
Q
I
A
D
D
I
L
D
V
T
G
D
S
A
Q
V
G
K
A
V
G
K
D
A
S
A
G
K
A
T
F
V
S
L
L
G
L
D
A
A
R
A
R
A
M
--------
S
L
I
D
E
A
C
D
S
L
A
T
Y
G
A
K
A
D
T
L
-
R
E
-
T
A
-
R
F
-
V
V
R
R
T
H
-----------
25
PsiBlast_CBE
56.20
45%
-79
- C1 -
3KRP
3
?
D:
[33-269]
----------------------------------
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
-----------
A
C
E
--
L
V
-
G
G
DEST
A
M
P
-
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
A
P
---
P
E
---
R
I
V
R
----
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
-
V
C
S
E
G
---
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
----
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
-----------
T
Y
P
K
L
I
G
V
E
----
K
S
K
--------
E
F
A
D
---
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
P
-
H
R
-
A
A
-
P
L
I
A
L
A
N
-
Y
I
A
Y
R
D
N
--
24
PsiBlast_CBE
53.28
45%
-63
- C1 -
3OAB
4
?
D:
[33-269]
----------------------------------
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
-----------
A
C
E
--
L
V
-
G
G
DEST
A
M
P
-
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
A
P
---
P
E
---
R
I
V
R
----
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
-
V
C
S
E
G
---
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
----
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
----
K
S
K
--------
E
F
A
D
---
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
P
-
H
R
-
A
A
-
P
L
I
A
L
A
N
-
Y
I
A
Y
R
D
N
--
26
PsiBlast_CBE
52.30
45%
-64
- C1 -
3KRO
4
?
D:
[33-269]
----------------------------------
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
-----------
A
C
E
--
L
V
-
G
G
DEST
A
M
P
-
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
A
P
---
P
E
---
R
I
V
R
----
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
-
V
C
S
E
G
---
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
----
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
----
K
S
K
--------
E
F
A
D
---
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
P
-
H
R
-
A
A
-
P
L
I
A
L
A
N
-
Y
I
A
Y
R
D
N
--
23
PsiBlast_CBE
50.35
45%
-63
- C1 -
3OAC
4
?
D:
[33-269]
----------------------------------
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
-----------
A
C
E
--
L
V
-
G
G
DEST
A
M
P
-
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
A
P
---
P
E
---
R
I
V
R
----
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
-
V
C
S
E
G
---
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
----
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
----
K
S
K
--------
E
F
A
D
---
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
P
-
H
R
-
A
A
-
P
L
I
A
L
A
N
-
Y
I
A
Y
R
D
N
--
27
PsiBlast_CBE
49.79
45%
-64
- C1 -
3KRF
4
?
D:
[33-269]
----------------------------------
E
S
M
R
Y
S
L
L
A
G
G
K
R
V
R
P
M
L
C
I
A
-----------
A
C
E
--
L
V
-
G
G
DEST
A
M
P
-
A
A
C
A
V
E
M
I
H
T
M
S
L
M
H
D
D
L
P
C
M
D
N
D
D
L
R
R
G
K
P
T
N
H
M
A
F
G
E
S
V
A
V
L
A
G
D
A
L
L
S
F
A
F
E
H
V
A
A
A
TK
G
A
P
---
P
E
---
R
I
V
R
----
V
L
G
E
--
L
A
V
S
I
G
S
E
G
L
V
A
G
Q
V
V
D
-
V
C
S
E
G
---
M
A
E
V
G
L
D
H
L
E
F
I
H
H
H
K
T
A
A
L
L
Q
G
S
----
V
V
L
G
A
I
L
G
-
G
G
K
E
-
E
E
V
A
K
L
R
K
F
A
N
C
I
G
L
L
F
Q
V
V
D
D
I
L
D
V
T
K
S
S
K
E
L
G
K
T
A
G
K
D
L
V
A
D
K
T
T
Y
P
K
L
I
G
V
E
----
K
S
K
--------
E
F
A
D
---
R
L
N
R
E
A
Q
E
Q
L
L
H
F
-
H
P
-
H
R
-
A
A
-
P
L
I
A
L
A
N
-
Y
I
A
Y
R
D
N
--
36
PsiBlast_CBE
49.16
39%
-61
- C1 -
3Q1O
5
?
C:
[41-297]
------------------------------
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
CALVGQ
K
D
Y
S
N
Q
--
Q
T
-
E
-----
Y
F
K
-
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
--
L
L
E
---
S
H
---
I
I
V
E
----
L
I
K
I
--
L
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
N
---
T
P
-
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
LIMG
L
V
A
S
G
I
----
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--
S
A
K
N
S
F
V
N
L
L
G
L
E
----
R
A
N
NYAQTLKT
E
V
L
N
DL-
D
A
L
K
P
A
Y
P
L
L
Q
E
N
-
L
N
-
A
L
-
L
N
-
T
L
F
K
-------------
16
PsiBlast_PDB
48.82
39%
-60
- C1 -
3Q1O
4
?
A:
[41-297]
------------------------------
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
--
Q
T
-
E
-----
Y
F
K
-
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
--
L
L
E
---
S
H
---
I
I
V
E
----
L
I
K
I
--
L
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
N
---
T
P
-
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
----
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--
S
A
K
N
S
F
V
N
L
L
G
L
E
----
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
-
D
A
L
K
P
A
Y
P
L
L
Q
E
N
-
L
N
-
A
L
-
L
N
-
T
L
F
K
G
------------
35
PsiBlast_CBE
47.67
39%
-56
- C1 -
3Q1O
3
?
D:
[41-297]
------------------------------
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
CALVGQ
K
D
Y
S
N
Q
--
Q
T
-
E
-----
Y
F
K
-
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
--
L
L
E
---
S
H
---
I
I
V
E
----
L
I
K
I
--
L
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
N
---
T
P
-
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
LIMG
L
V
A
S
G
I
----
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--
S
A
K
N
S
F
V
N
L
L
G
L
E
----
R
A
N
NYAQTLKT
E
V
L
N
DL-
D
A
L
K
P
A
Y
P
L
L
Q
E
N
-
L
N
-
A
L
-
L
N
-
T
L
F
K
-------------
37
PsiBlast_CBE
47.56
39%
-59
- C1 -
3Q1O
4
?
B:
[41-297]
------------------------------
P
Y
L
E
K
A
F
F
E
M
V
L
N
G
G
K
R
F
R
P
K
L
F
L
A
V
L
C
A
L
V
G
Q
K
D
Y
S
N
Q
--
Q
T
-
E
-----
Y
F
K
-
I
A
L
S
I
E
C
L
H
T
Y
S
L
I
H
D
D
L
P
C
M
D
N
A
A
L
R
R
N
H
P
T
L
H
A
K
Y
D
E
T
T
A
V
L
I
G
D
A
L
N
T
Y
S
F
E
L
L
S
N
A
--
L
L
E
---
S
H
---
I
I
V
E
----
L
I
K
I
--
L
S
A
N
G
G
I
K
G
M
I
L
G
Q
A
L
D
-
C
Y
F
E
N
---
T
P
-
L
N
L
E
Q
L
T
F
L
H
E
H
K
T
A
K
L
I
S
A
S
L
I
M
G
L
V
A
S
G
I
----
K
D
E
-
E
L
F
K
W
L
Q
A
F
G
L
K
M
G
L
C
F
Q
V
L
D
D
I
I
D
V
T
Q
D
E
E
E
S
G
K
T
T
H
L
D
--
S
A
K
N
S
F
V
N
L
L
G
L
E
----
R
A
N
N
Y
A
Q
T
L
K
T
E
V
L
N
D
L
-
D
A
L
K
P
A
Y
P
L
L
Q
E
N
-
L
N
-
A
L
-
L
N
-
T
L
F
K
G
------------
60
PsiBlast_CBE
40.49
31%
-64
- C1 -
3WJO
2
?
A:
[52-293]
--------------------------------------
Y
I
V
S
G
G
G
K
R
I
R
P
M
I
A
V
L
A
A
------
R
A
V
G
Y
E
---
G
-
N
A
----
H
V
T
-
I
A
A
L
I
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
E
S
D
M
R
R
G
K
A
T
A
N
A
A
F
G
N
A
A
S
V
L
V
G
D
F
I
Y
T
R
A
F
Q
M
M
T
S
L
--
G
-----------
S
L
K
----
V
L
E
V
--
M
S
E
A
V
N
V
--
I
A
E
G
E
V
L
Q
-
L
M
N
------------
N
Y
M
R
V
I
Y
S
K
T
A
R
L
F
E
A
A
----
A
Q
C
S
G
I
L
A
-
G
C
T
P
-
E
E
E
K
G
L
Q
D
Y
G
R
Y
L
G
T
A
F
Q
L
I
D
D
L
L
D
Y
N
A
--------
V
G
D
D
L
N
E
G
K
P
T
L
P
L
L
H
A
M
H
----
H
G
-----------------
T
P
E
Q
A
Q
M
I
R
T
A
I
-
E
Q
-
G
-----
N
G
R
H
L
L
E
P
V
L
E
A
M
N
A
C
G
64
PsiBlast_CBE
39.37
31%
-47
- C1 -
3OYR
4
?
B:
[47-297]
----------------
Q
S
D
V
-----
A
I
I
--
P
A
L
A
E
H
L
I
A
A
---
G
G
K
R
L
R
P
L
M
T
V
A
A
A
------
R
L
A
G
A
D
-----
N
D
----
H
F
Q
K
L
A
A
A
V
E
F
I
H
T
A
T
L
L
H
D
D
V
--
V
D
G
S
Q
L
R
R
G
K
V
A
A
H
L
I
W
G
G
A
Q
S
V
L
V
G
D
F
L
F
A
R
A
F
E
L
M
V
E
T
--
N
-----------
S
M
K
----
A
L
E
I
--
L
A
R
A
--
S
R
V
I
A
E
G
E
V
L
Q
L
M
R
S
H
D
---
L
N
-
L
S
Q
A
V
Y
L
E
I
I
Q
A
K
T
A
E
L
F
A
A
A
S
E
A
G
A
V
S
A
G
V
D
V
-
A
K
S
E
-----
A
L
R
D
Y
G
L
N
L
G
L
A
F
Q
L
A
D
D
A
L
D
Y
G
G
A
T
E
T
L
G
K
N
A
G
D
D
F
R
E
G
K
A
T
L
P
L
L
L
A
I
A
----
R
S
G
--------
P
R
E
A
---
E
F
W
E
R
--
A
I
G
R
R
E
-
Q
T
-
E
A
-
D
F
R
R
A
R
E
L
I
I
-
G
S
G
A
L
D
A
T
L