@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0608: (2015-12-02 )
MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYGGLGTQKAVDNVNNVIAEAIIGYDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIMPVGAPTFKEALRWGAEVFHALKKILKERGLETAVGDEGGFAPKFEGTEDGVETILKAIEAAGYEAGENGIMIGFDCASSEFYDAERKVYDYSKFEGEGGAVRTAAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGGRVQLVGDDFFVTNTDYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNLKK
Atome Classification :
(60 SA)
.........10........20........30----------........40-........50........60........70........80-.--........90........100.......110.......120.......130.---..---..-----.-----.---140---.-........150.......160.......170.......180......----.190....--.--..--200-.--.......210.......220.......230.......240.......250....-...260.----.......270----....-...-280.......290.......300.......310.......320........330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430....-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
I
I
T
D
V
Y
A
R
E
V
L
DSRGN
P
T
L
E
V
E
V
Y
TESGA----------FGRGMVPSGA-STGEH
E
A
V
E
LRDGDKSRYGGLG
T
Q
K
A
V
D
N
V
N
N
V
I
A
E
A
I
I--G--YDV
R
D
Q
Q
A
I
D
R
A
M
I
A
LDGTPNKGKLGA
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
S
Y
---LG---GF-----N-----T---K-----V-LP
T
P
M
M
N
I
INGGSHSDA
P
I
A
F
Q
E
F
M
I
MPVG
A
P
T
F
K
E
A
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
ER--G--LE--TA--V--GDEGGFAPKFEG
T
E
D
G
V
E
T
I
L
K
A
I
E
AAGYEAGEN
G
I
M
I
G
F
DCASSEF
Y
D
A
E
RKV-YDYS-KF----EGEGG
A
V
R
T
A
----
A
E
Q
I
-
D
Y
L
-
E
E
L
V
NKY
P
I
I
T
IEDGMDENDW
D
G
W
K
A
L
T
E
RLG
G
R
V
Q
L
V
GD
D
F
-
F
V
T
N
T
D
Y
L
A
R
G
I
K
E
EAA
N
S
I
L
I
K
VNQIG
T
L
T
E
T
F
E
A
I
E
M
A
K
EAG
Y
T
A
V
V
SHRSGETEDS
T
I
A
D
I
A
V
ATNAG
Q
I
KTGSLS
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-YNLKK-
1
PsiBlast_PDB
97.24
96%
-82
- C1 -
3ZLH
-
ENO_STRP6
A:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
-----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
R
T
S
----
A
E
Q
V
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
---
24
PsiBlast_CBE
97.23
96%
-80
- C1 -
3ZLG
2
ENO_STRP6
D:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
R
T
S
----
A
E
Q
V
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
---
26
PsiBlast_CBE
97.01
96%
-80
- C1 -
3ZLG
2
ENO_STRP6
B:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
R
T
S
----
A
E
Q
V
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
---
22
PsiBlast_CBE
96.73
96%
-78
- C1 -
3ZLF
2
ENO_STRP6
C:
[21-454]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
R
T
S
----
A
E
Q
V
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
K
--
23
PsiBlast_CBE
96.33
96%
-77
- C1 -
3ZLF
2
ENO_STRP6
B:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
R
T
S
----
A
E
Q
V
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
---
21
PsiBlast_CBE
96.23
96%
-77
- C1 -
3ZLF
2
ENO_STRP6
D:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
R
T
S
----
A
E
Q
V
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
A
R
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
---
25
PsiBlast_CBE
96.15
96%
-78
- C1 -
3ZLG
2
ENO_STRP6
C:
[21-453]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
K
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
E
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
L
K
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
R
T
S
----
A
E
Q
V
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
V
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
E
Y
L
A
R
G
I
K
E
N
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
A
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
Q
Y
K
G
I
K
S
F
-
Y
N
L
---
2
PsiBlast_PDB
95.54
95%
-83
- C1 -
4EWJ
-
?
A:
[1-433]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
L
G
L
G
T
Q
K
A
V
D
N
V
N
N
V
I
A
D
A
I
I
--
G
--
F
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
T
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
S
F
K
E
G
L
R
W
G
A
E
V
F
H
A
----
L
K
K
I
L
K
A
R
--
G
--
L
V
--
T
A
--
V
--
G
D
E
G
G
F
A
P
K
F
E
G
T
E
D
G
V
E
T
I
I
E
A
I
E
A
A
G
Y
E
A
G
E
N
G
I
M
I
G
F
D
C
A
S
S
E
F
Y
D
--
R
K
V
-
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
R
T
S
----
A
E
Q
I
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
R
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
D
Y
L
A
R
G
I
K
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
V
Y
K
G
L
N
S
F
-
Y
N
L
---
4
PsiBlast_PDB
89.57
80%
-77
- C1 -
1IYX
6
ENO_ENTHR
A:
[2-430]
-
S
I
I
T
D
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
A
L
R
M
G
A
E
V
F
H
A
----
L
A
A
I
L
K
S
R
--
G
--
L
A
--
T
S
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
V
I
I
E
A
I
E
K
A
G
Y
V
P
G
K
D
-
V
V
L
A
M
D
A
A
S
S
E
F
Y
D
K
E
K
G
V
-
Y
V
L
A
-
D
-----
S
G
E
G
E
--
K
T
T
----
D
E
M
I
-
K
F
Y
-
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
D
D
L
-
F
V
T
N
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
-
Y
N
L
K
A
-
28
PsiBlast_CBE
89.50
80%
-75
- C1 -
1IYX
5
ENO_ENTHR
B:
[2-430]
-
S
I
I
T
D
V
Y
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
A
R
Y
G
G
K
G
V
T
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
M
A
I
D
K
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
V
P
L
Y
H
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
A
D
N
S
I
D
F
Q
E
F
M
I
M
P
V
G
A
P
T
F
K
E
A
L
R
M
G
A
E
V
F
H
A
----
L
A
A
I
L
K
S
R
--
G
--
L
A
--
T
S
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
G
F
E
V
I
I
E
A
I
E
K
A
G
Y
V
P
G
K
D
-
V
V
L
A
M
D
A
A
S
S
E
F
Y
D
K
E
K
G
V
-
Y
V
L
A
-
D
-----
S
G
E
G
E
--
K
T
T
----
D
E
M
I
-
K
F
Y
-
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
D
G
F
K
K
L
T
D
V
L
G
D
K
V
Q
L
V
G
D
D
L
-
F
V
T
N
T
Q
K
L
S
E
G
I
E
K
G
I
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
S
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
K
G
L
K
S
F
-
Y
N
L
K
A
-
29
PsiBlast_CBE
88.54
70%
-78
- C1 -
4A3R
3
ENO_BACSU
D:
[1-428]
M
P
Y
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
---
G
F
-----
N
-----
S
---
K
-----
T
-
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
----
L
K
S
V
L
S
A
K
--
G
--
L
N
--
T
A
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
-
V
K
L
A
M
D
A
A
S
S
E
F
Y
N
K
E
D
G
K
-
Y
H
L
S
--------
G
E
-
G
V
V
K
T
S
----
A
E
M
V
-
D
W
Y
-
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
L
-
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
-
Y
N
L
---
5
PsiBlast_PDB
87.94
70%
-80
- C1 -
4A3R
-
ENO_BACSU
A:
[1-428]
M
P
Y
I
V
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
Y
T
E
T
G
A
----------
F
G
R
A
L
V
P
S
G
A
-
S
T
G
E
Y
E
A
V
E
L
R
D
G
D
K
D
R
Y
L
G
K
G
V
L
T
A
V
N
N
V
N
E
I
I
A
P
E
L
L
--
G
--
F
D
V
T
E
Q
N
A
I
D
Q
L
L
I
E
L
D
G
T
E
N
K
G
K
L
G
A
N
A
I
L
G
V
S
M
A
C
A
R
A
A
A
D
F
L
Q
I
P
L
Y
Q
Y
---
L
G
---
G
F
-----
N
-----
S
---
K
-----
T
-
L
P
V
P
M
M
N
I
V
N
G
G
E
H
A
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
P
N
F
R
E
A
L
R
M
G
A
Q
I
F
H
S
----
L
K
S
V
L
S
A
K
--
G
--
L
N
--
T
A
--
V
--
G
D
E
G
G
F
A
P
N
L
G
S
N
E
E
A
L
Q
T
I
V
E
A
I
E
K
A
G
F
K
P
G
E
E
-
V
K
L
A
M
D
A
A
S
S
E
F
Y
N
K
E
D
G
K
-
Y
H
L
S
--------
G
E
-
G
V
V
K
T
S
----
A
E
M
V
-
D
W
Y
-
E
E
L
V
S
K
Y
P
I
I
S
I
E
D
G
L
D
E
N
D
W
E
G
H
K
L
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
L
-
F
V
T
N
T
K
K
L
S
E
G
I
K
N
G
V
G
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
D
A
I
E
M
A
K
R
A
G
Y
T
A
V
I
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
A
P
S
R
T
D
R
V
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
A
E
T
A
Q
Y
H
G
I
N
S
F
-
Y
N
L
---
30
PsiBlast_CBE
85.56
68%
-83
- C1 -
4MKS
1
ENO2_LACGA
B:
[3-428]
--
V
I
T
D
I
H
A
R
E
V
L
D
S
R
G
N
P
T
A
E
A
E
V
Y
T
E
L
G
G
----------
F
G
R
A
I
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
F
G
G
Q
G
V
L
T
A
V
E
N
V
N
G
E
I
A
K
A
V
I
--
G
--
L
D
V
T
D
Q
R
L
I
D
Q
T
M
I
D
L
D
G
T
P
N
K
G
R
L
G
A
N
A
I
L
S
V
S
L
A
S
A
R
A
A
A
D
E
L
G
L
P
L
Y
E
Y
---
L
G
---
G
P
-----
N
-----
A
---
H
-----
V
-
L
P
T
P
M
M
N
V
I
N
G
------
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
K
S
L
H
E
A
V
R
M
G
A
E
T
F
H
T
----
L
K
G
L
L
Q
E
R
--
G
--
E
S
--
T
A
--
V
--
G
D
E
G
G
F
A
P
---
N
N
E
E
P
F
E
I
L
V
E
A
I
Q
R
A
G
Y
K
P
G
Q
D
-
I
A
I
A
F
D
C
A
A
S
E
F
Y
----------------------------------
W
T
-
S
L
I
-
E
D
L
V
D
K
Y
P
V
I
S
V
E
D
P
L
D
E
N
D
W
E
G
W
K
T
F
T
E
R
L
G
D
K
V
Q
I
V
G
D
D
L
-
F
V
T
N
T
S
Y
L
E
K
G
I
K
M
G
V
A
N
S
I
L
I
K
L
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
S
M
S
R
T
D
R
I
A
K
Y
N
Q
L
M
R
I
E
E
A
L
G
S
T
A
Q
Y
K
G
I
H
S
F
-
Y
N
L
---
6
PsiBlast_PDB
85.25
68%
-82
- C1 -
4MKS
2
ENO2_LACGA
A:
[3-428]
--
V
I
T
D
I
H
A
R
E
V
L
D
S
R
G
N
P
T
A
E
A
E
V
Y
T
E
L
G
G
----------
F
G
R
A
I
V
P
S
G
A
-
S
T
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
F
G
G
Q
G
V
L
T
A
V
E
N
V
N
G
E
I
A
K
A
V
I
--
G
--
L
D
V
T
D
Q
R
L
I
D
Q
T
M
I
D
L
D
G
T
P
N
K
G
R
L
G
A
N
A
I
L
S
V
S
L
A
S
A
R
A
A
A
D
E
L
G
L
P
L
Y
E
Y
---
L
G
---
G
P
-----
N
-----
A
---
H
-----
V
-
L
P
T
P
M
M
N
V
I
N
G
G
---
D
N
N
V
D
I
Q
E
F
M
I
M
P
V
G
A
K
S
L
H
E
A
V
R
M
G
A
E
T
F
H
T
----
L
K
G
L
L
Q
E
R
--
G
--
E
S
--
T
A
--
V
--
G
D
E
G
G
F
A
P
---
N
N
E
E
P
F
E
I
L
V
E
A
I
Q
R
A
G
Y
K
P
G
Q
D
-
I
A
I
A
F
D
C
A
A
S
E
F
Y
----------------------------------
W
T
-
S
L
I
-
E
D
L
V
D
K
Y
P
V
I
S
V
E
D
P
L
D
E
N
D
W
E
G
W
K
T
F
T
E
R
L
G
D
K
V
Q
I
V
G
D
D
L
-
F
V
T
N
T
S
Y
L
E
K
G
I
K
M
G
V
A
N
S
I
L
I
K
L
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
S
M
S
R
T
D
R
I
A
K
Y
N
Q
L
M
R
I
E
E
A
L
G
S
T
A
Q
Y
K
G
I
H
S
F
-
Y
N
L
---
110
HHSearch
85.16
94%
-29
- C- -
1W6T
2
ENO_STRPN
A:
[11-443]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
----
L
K
K
I
L
K
S
R
--
G
--
L
E
--
T
A
--
V
--
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
-
D
V
F
L
G
F
D
C
A
S
S
E
F
Y
D
--
R
K
V
-
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
R
T
S
----
A
E
Q
I
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
-
Y
N
L
K
--
27
PsiBlast_CBE
84.82
93%
-29
- C- -
1W6T
2
ENO_STRPN
B:
[11-443]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
----
L
K
K
I
L
K
S
R
--
G
--
L
E
--
T
A
--
V
--
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
D
-
V
F
L
G
F
D
C
A
S
S
E
F
Y
D
K
E
R
K
V
-
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
R
T
S
----
A
E
Q
I
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
-
Y
N
L
K
--
3
PsiBlast_PDB
84.60
93%
-28
- C- -
1W6T
2
ENO_STRPN
A:
[11-443]
M
S
I
I
T
D
V
Y
A
R
E
V
L
D
S
R
G
N
P
T
L
E
V
E
V
Y
T
E
S
G
A
----------
F
G
R
G
M
V
P
S
G
----
G
E
H
E
A
V
E
L
R
D
G
D
K
S
R
Y
G
G
L
G
T
Q
K
A
V
D
N
V
N
N
I
I
A
E
A
I
I
--
G
--
Y
D
V
R
D
Q
Q
A
I
D
R
A
M
I
A
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
V
S
I
A
V
A
R
A
A
A
D
Y
L
E
I
P
L
Y
S
Y
---
L
G
---
G
F
-----
N
-----
T
---
K
-----
V
-
L
P
T
P
M
M
N
I
I
N
G
G
S
H
S
D
A
P
I
A
F
Q
E
F
M
I
L
P
V
G
A
P
T
F
K
E
A
L
R
Y
G
A
E
I
F
H
A
----
L
K
K
I
L
K
S
R
--
G
--
L
E
--
T
A
--
V
--
G
D
E
G
G
F
A
P
R
F
E
G
T
E
D
G
V
E
T
I
L
A
A
I
E
A
A
G
Y
V
P
G
K
D
-
V
F
L
G
F
D
C
A
S
S
E
F
Y
D
--
R
K
V
-
Y
D
Y
T
-
K
F
----
E
G
E
G
A
A
V
R
T
S
----
A
E
Q
I
-
D
Y
L
-
E
E
L
V
N
K
Y
P
I
I
T
I
E
D
G
M
D
E
N
D
W
D
G
W
K
A
L
T
E
R
L
G
K
K
V
Q
L
V
G
D
D
F
-
F
V
T
N
T
D
Y
L
A
R
G
I
Q
E
G
A
A
N
S
I
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
E
A
I
E
M
A
K
E
A
G
Y
T
A
V
V
S
H
R
S
G
E
T
E
D
S
T
I
A
D
I
A
V
A
T
N
A
G
Q
I
K
T
G
S
L
S
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
D
Q
L
G
E
V
A
E
Y
R
G
L
K
S
F
-
Y
N
L
K
--
111
HHSearch
84.40
61%
-80
- C1 -
3TQP
2
ENO_COXBU
A:
[2-426]
T
A
T
I
T
D
I
N
A
H
E
I
L
D
S
R
A
N
P
T
L
E
V
R
V
T
L
S
S
Q
A
----------
Y
G
C
A
A
V
P
S
G
A
----
E
R
E
A
V
E
L
R
D
N
D
L
E
R
Y
G
G
K
G
V
L
Q
A
V
E
N
V
N
G
P
I
R
D
A
L
L
--
G
--
Q
D
P
R
S
Q
E
E
I
D
R
I
M
I
E
L
D
G
T
E
N
K
A
N
L
G
A
N
A
I
L
G
V
S
L
A
V
A
Y
A
A
A
N
N
A
D
L
P
L
Y
R
Y
---
L
G
---
G
D
-----
G
G----
P
---
F
-----
S
-
M
P
V
P
M
M
N
I
I
N
G
G
----
N
N
L
D
F
Q
E
F
M
I
V
P
V
G
A
P
T
F
A
E
A
L
R
Y
G
A
E
V
F
H
A
----
L
K
K
R
L
V
S
R
--
G
--
L
M
--
S
A
--
V
--
G
D
E
G
G
F
A
P
D
L
P
N
N
E
A
A
F
E
L
I
L
E
A
I
E
D
A
N
Y
V
P
G
K
-
D
I
Y
L
A
L
D
A
A
S
S
E
L
Y
Q
--
N
G
R
-
Y
D
F
E
-
N
N
----------
Q
L
T
S
----
E
E
M
I
-
D
R
L
-
T
E
W
T
K
K
Y
P
V
I
S
I
E
D
G
L
S
E
N
D
W
A
G
W
K
L
L
T
E
R
L
E
N
K
V
Q
L
V
G
D
D
I
-
F
V
T
N
P
D
I
L
E
K
G
I
K
K
N
I
A
N
A
I
L
V
K
L
N
Q
I
G
T
L
T
E
T
L
A
T
V
G
L
A
K
S
N
K
Y
G
V
I
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
D
A
R
Q
I
K
T
G
S
L
C
R
S
D
R
V
A
K
Y
N
R
L
L
Q
I
E
R
E
L
N
D
Q
A
P
Y
A
G
K
E
A
F
-
L
F
N
---
14
PsiBlast_PDB
84.40
58%
-82
- C1 -
3TQP
2
ENO_COXBU
A:
[3-426]
-
A
T
I
T
D
I
N
A
H
E
I
L
D
S
R
A
N
P
T
L
E
V
R
V
T
L
S
S
Q
A
----------
Y
G
C
A
A
V
P
S
G
A
----
E
R
E
A
V
E
L
R
D
N
D
L
E
R
Y
G
G
K
G
V
L
Q
A
V
E
N
V
N
G
P
I
R
D
A
L
L
--
G
--
Q
D
P
R
S
Q
E
E
I
D
R
I
M
I
E
L
D
G
T
E
N
K
A
N
L
G
A
N
A
I
L
G
V
S
L
A
V
A
Y
A
A
A
N
N
A
D
L
P
L
Y
R
Y
---
L
G
---
G
D
-----
G
-----
G
---
P
-----
F
S
M
P
V
P
M
M
N
I
I
N
G
G
----
N
N
L
D
F
Q
E
F
M
I
V
P
V
G
A
P
T
F
A
E
A
L
R
Y
G
A
E
V
F
H
A
----
L
K
K
R
L
V
S
R
--
G
--
L
M
--
S
A
--
V
--
G
D
E
G
G
F
A
P
D
L
P
N
N
E
A
A
F
E
L
I
L
E
A
I
E
D
A
N
Y
V
P
G
K
D
-
I
Y
L
A
L
D
A
A
S
S
E
L
Y
Q
N
G
R
---
Y
D
F
E
-
N
N
----
Q
------
L
T
S
----
E
E
M
I
-
D
R
L
-
T
E
W
T
K
K
Y
P
V
I
S
I
E
D
G
L
S
E
N
D
W
A
G
W
K
L
L
T
E
R
L
E
N
K
V
Q
L
V
G
D
D
I
-
F
V
T
N
P
D
I
L
E
K
G
I
K
K
N
I
A
N
A
I
L
V
K
L
N
Q
I
G
T
L
T
E
T
L
A
T
V
G
L
A
K
S
N
K
Y
G
V
I
I
S
H
R
S
G
E
T
E
D
T
T
I
A
D
L
A
V
A
T
D
A
R
Q
I
K
T
G
S
L
C
R
S
D
R
V
A
K
Y
N
R
L
L
Q
I
E
R
E
L
N
D
Q
A
P
Y
A
G
K
E
A
F
L
F
N
----
33
PsiBlast_CBE
83.36
60%
-88
- C1 -
4YWS
1
ENO_CHLAA
B:
[3-424]
-
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
-----------
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
V
-----
Y
-----
A
---
H
-----
V
-
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
T
---
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
------------------
E
G
G
F
A
P
S
L
-
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
----
Y
----
H
L
-
K
-----
E
G
R
-----
S
S
----
A
E
M
V
-
D
Y
W
-
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
-
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
-
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
-
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
-
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
-
K
V
----
7
PsiBlast_PDB
81.41
60%
-73
- C1 -
4Z17
3
ENO_CHLAA
A:
[3-424]
-
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
V
-----
Y
-----
A
---
H
-----
V
-
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
--
N
S
T
D
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
--
G
--
F
S
--
T
T
--
V
--
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
E
D
G
K
Y
----
H
L
-
K
R
----
E
G
R
S
---
L
S
S
----
A
E
M
V
-
D
Y
W
-
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
-
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
-
K
V
----
32
PsiBlast_CBE
79.94
60%
-74
- C1 -
4Z17
3
ENO_CHLAA
B:
[3-424]
-
T
L
I
E
A
I
V
A
R
E
V
L
D
S
R
G
N
P
T
I
E
V
D
V
R
L
E
S
G
D
----------
V
G
R
A
I
V
P
S
G
A
-
S
T
G
A
H
E
A
L
E
L
R
D
G
D
K
S
R
Y
N
G
K
G
V
L
K
A
V
Q
A
V
N
E
D
I
A
E
A
L
I
--
G
--
F
D
A
A
D
Q
I
A
L
D
Q
E
L
I
A
L
D
G
T
P
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
A
K
A
A
A
A
A
F
G
L
P
L
Y
R
Y
---
L
G
---
G
V
-----
Y
-----
A
---
H
-----
V
-
L
P
V
P
M
M
N
I
M
N
G
G
Q
H
A
-----
F
Q
E
F
M
I
M
P
V
G
A
E
S
F
R
E
G
L
R
W
G
A
E
I
Y
H
M
----
L
K
K
V
I
H
D
R
--
G
--
F
S
--
T
T
--
V
--
G
D
E
G
G
F
A
P
S
L
P
T
N
D
A
P
L
Q
L
I
M
E
A
I
E
K
A
G
Y
R
P
G
E
Q
-
I
V
I
A
L
D
P
A
T
T
E
I
F
E
D
G
K
Y
----
H
L
-
K
R
----
E
G
R
S
---
L
S
S
----
A
E
M
V
-
D
Y
W
-
V
D
L
V
N
R
Y
P
I
I
S
L
E
D
G
L
A
E
D
D
W
E
G
W
A
L
L
R
A
K
L
G
D
R
V
Q
L
V
G
D
D
F
-
L
V
T
N
V
Q
R
L
Q
R
A
I
E
A
K
A
A
N
S
I
L
I
K
L
N
Q
I
G
S
L
T
E
T
L
S
A
I
Q
L
A
Q
R
S
G
W
T
A
V
V
S
H
R
S
G
E
S
E
D
V
T
I
A
D
L
V
V
A
T
N
A
G
Q
I
K
T
G
A
P
A
R
T
D
R
I
A
K
Y
N
Q
L
L
R
I
E
E
E
L
G
S
A
A
R
Y
A
G
R
S
A
F
-
K
V
----
56
PsiBlast_CBE
79.93
49%
-75
- C1 -
3UJR
3
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
58
PsiBlast_CBE
79.82
49%
-74
- C1 -
3UJF
3
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
53
PsiBlast_CBE
79.12
49%
-72
- C1 -
3UCC
3
ENOG_HUMAN
B:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
18
PsiBlast_PDB
78.53
49%
-72
- C1 -
3UCC
4
ENOG_HUMAN
A:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
52
PsiBlast_CBE
78.52
49%
-71
- C1 -
3UCD
3
ENOG_HUMAN
B:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
117
HHSearch
78.36
50%
-67
- C1 -
2AL1
3
ENO1_YEAST
A:
[1-429]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
-----------
F
-
R
S
I
V
P
S
G
A
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
KSKTS
P
---
Y
-----
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
Y-
G
A-
S
A
--
G
N
--
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
--
H
D
G
-
K
V
K
I
G
L
D
C
A
S
S
E
F
F
K
--
D
G
K
-
Y
D
L
D
-
F
K
NP--
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
54
PsiBlast_CBE
78.35
49%
-74
- C1 -
3UJS
3
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
61
PsiBlast_CBE
78.34
49%
-72
- C1 -
3UJE
4
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
77
PsiBlast_CBE
78.32
49%
-70
- C1 -
2AL1
3
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
19
PsiBlast_PDB
78.16
49%
-71
- C1 -
3UCD
3
ENOG_HUMAN
A:
[2-429]
---
I
Q
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
60
PsiBlast_CBE
78.15
49%
-72
- C1 -
3UJE
3
ENOG_HUMAN
B:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
SS
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
IAQ
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
57
PsiBlast_CBE
78.09
49%
-73
- C1 -
3UJR
4
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
59
PsiBlast_CBE
78.08
49%
-70
- C1 -
3UJF
3
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
55
PsiBlast_CBE
77.86
49%
-72
- C1 -
3UJS
4
ENOG_HUMAN
A:
[2-429]
---
I
E
K
I
W
A
R
E
I
L
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
A
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
I
Y
E
A
L
E
L
R
D
G
D
K
Q
R
Y
L
G
K
G
V
L
K
A
V
D
H
I
N
S
T
I
A
P
A
L
I
S
S
G
--
L
S
V
V
E
Q
E
K
L
D
N
L
M
L
E
L
D
G
T
E
N
K
S
K
F
G
A
N
A
I
L
G
V
S
L
A
V
C
K
A
G
A
A
E
R
E
L
P
L
Y
R
H
I
A
Q
L
A
---
G
N
-----
S
-----
D
---
L
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
V
G
A
E
S
F
R
D
A
M
R
L
G
A
E
V
Y
H
T
----
L
K
G
V
I
K
D
K
Y-
G
--
K
D
A-
T
N
--
V
--
G
D
E
G
G
F
A
P
N
I
L
E
N
S
E
A
L
E
L
V
K
E
A
I
D
K
A
G
Y
T
---
E
K
I
V
I
G
M
D
V
A
A
S
E
F
Y
R
D
G
K
---
Y
D
L
D
-
F
K
----
S
P
T
D
P
S
R
Y
I
T
----
G
D
Q
L
-
G
A
L
Y
Q
D
F
V
R
D
Y
P
V
V
S
I
E
D
P
F
D
Q
D
D
W
A
A
W
S
K
F
T
A
N
V
G
--
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
E
R
A
V
E
E
K
A
C
N
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
A
I
Q
A
C
K
L
A
Q
E
N
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
L
M
R
I
E
E
E
L
G
D
E
A
R
F
A
G
-
H
N
F
-
R
N
P
S
V
-
76
PsiBlast_CBE
77.80
49%
-72
- C1 -
2AL1
6
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
96
PsiBlast_CBE
77.56
49%
-67
- C1 -
1P48
3
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
Q
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
78
PsiBlast_CBE
77.50
49%
-69
- C1 -
1ONE
3
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSPY
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
75
PsiBlast_CBE
77.48
49%
-69
- C1 -
2ONE
3
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
79
PsiBlast_CBE
77.36
49%
-70
- C1 -
1ONE
3
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
101
Fugue
77.29
50%
-66
- C1 -
1ONE
3
ENO1_YEAST
A:
[1-436]
--
A
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
-----------
V
F
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
N
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
S
KSKT
S
-----
P
---
Y
-----
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
YG
A
--
S
A
--
G
N
--
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
---
G
K
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
-
G
K
Y
D
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
--
A
G
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
-
E
N
F
-
H
H
G
D
K
L
82
PsiBlast_CBE
77.07
49%
-67
- C1 -
1EBG
3
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSPY
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
84
PsiBlast_CBE
77.00
49%
-70
- C1 -
2AL2
5
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
--
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
--
K
A
D
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
D
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
-----
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
83
PsiBlast_CBE
76.98
49%
-69
- C1 -
1EBG
3
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
95
PsiBlast_CBE
76.84
49%
-66
- C1 -
1P48
3
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSPY
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
Q
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
100
PsiBlast_CBE
76.72
49%
-69
- C1 -
6ENL
2
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
99
PsiBlast_CBE
76.63
49%
-68
- C1 -
7ENL
2
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
S
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
74
PsiBlast_CBE
76.63
49%
-70
- C1 -
2ONE
2
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSPY
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
E
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
98
PsiBlast_CBE
76.52
49%
-69
- C1 -
1P43
3
ENO1_YEAST
A:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
K
A
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSP
Y
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
Q
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
88
PsiBlast_CBE
76.43
50%
-73
- C1 -
2PTY
4
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
-----
E
---
L
-----
R
-
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
--
Y
--
G
Q
--
D
A
--
V
NV
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
G
K
---
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
Q
-
Y
N
L
T
--
F
----
K
S
P
E
P
T
W
V
T
A
----
E
Q
L
R
-
E
T
Y
-
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
-
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
F
P
G
W
S
-------
97
PsiBlast_CBE
76.16
49%
-67
- C1 -
1P43
3
ENO1_YEAST
B:
[2-427]
---
V
S
K
V
Y
A
R
S
V
Y
D
S
R
G
N
P
T
V
E
V
E
L
T
T
E
K
G
V
----------
F
-
R
S
I
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
W
M
G
K
G
V
L
H
A
V
K
N
V
N
D
V
I
A
P
A
F
V
KA
N
--
I
D
V
K
D
Q
K
A
V
D
D
F
L
I
S
L
D
G
T
A
N
K
S
K
L
G
A
N
A
I
L
G
V
S
L
A
A
S
R
A
A
A
A
E
K
N
V
P
L
Y
K
H
---
L
A
---
D
L
-----
S
-----
K
---
S
KTSPY
V
-
L
P
V
P
F
L
N
V
L
N
G
G
S
H
A
G
G
A
L
A
L
Q
Q
F
M
I
A
P
T
G
A
K
T
F
A
E
A
L
R
I
G
S
E
V
Y
H
N
----
L
K
S
L
T
K
K
R
--
Y
--
G
A
--
S
A
GN
V
--
G
D
E
G
G
V
A
P
N
I
Q
T
A
E
E
A
L
D
L
I
V
D
A
I
K
A
A
G
H
D
G
K
---
V
K
I
G
L
D
C
A
S
S
E
F
F
K
D
G
K
Y
D
-
L
D
F
K
-
N
P
----
N
S
D
K
S
K
W
L
T
G
----
P
Q
L
A
-
D
L
Y
-
H
S
L
M
K
R
Y
P
I
V
S
I
E
D
P
F
A
E
D
D
W
E
A
W
S
H
F
F
K
T
A
G
--
I
Q
I
V
A
D
D
L
-
T
V
T
N
P
K
R
I
A
T
A
I
E
K
K
A
A
D
A
L
L
L
K
V
N
Q
I
G
T
L
S
E
S
I
K
A
A
Q
D
S
F
A
A
G
W
G
V
M
V
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
R
T
G
Q
I
K
T
G
A
P
A
R
S
E
R
L
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
D
N
A
V
F
A
G
E
N
F
H
-
H
G
D
K
L
-
87
PsiBlast_CBE
76.12
50%
-73
- C1 -
2PTZ
5
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
-----
E
---
L
-----
R
-
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
--
Y
--
G
Q
--
D
A
--
V
NV
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
G
K
---
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
Q
-
Y
N
L
T
--
F
----
K
S
P
E
P
T
W
V
T
A
----
E
Q
L
R
-
E
T
Y
-
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
-
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
F
P
G
W
S
-------
85
PsiBlast_CBE
75.65
50%
-74
- C1 -
2PU1
5
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
-----
E
---
L
-----
R
-
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
--
Y
--
G
Q
--
D
A
--
V
NV
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
G
K
---
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
Q
-
Y
N
L
T
--
F
----
K
S
P
E
P
T
W
V
T
A
----
E
Q
L
R
-
E
T
Y
-
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
-
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
F
P
G
W
S
-------
116
HHSearch
75.50
48%
-69
- C1 -
3QTP
6
ENO1_ENTHI
A:
[5-439]
S
M
S
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
F
R
S
C
V
P
S
GAS
T
G
V
H
E
A
V
E
L
R
-
D
-----------
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
---
E
L
-----
T
-----
G
HK
E
M
-----
T
-
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
--
Y
GQ
D
A
--
T
N
--
V
--
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
--
Y
T
G
-
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
T
K
K
-
Y
D
L
G
-
K
K
IPAD
K
K
D
P
S
L
V
K
D
V
----
D
G
L
I
-
A
E
Y
-
V
D
Y
G
K
H
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
H
G
-
N
F
Q
I
V
G
D
D
L
-
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
-
I
P
Y
A
G
K
N
-
W
-
R
N
S
T
A
-
86
PsiBlast_CBE
75.28
50%
-74
- C1 -
2PU0
7
?
A:
[6-426]
---
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
----------
F
-
R
S
A
V
P
S
G
A
-
S
T
G
V
Y
E
A
C
E
L
R
D
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
S
L
A
G
T
-----
K
-----
E
---
L
-----
R
-
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
----
L
R
G
I
I
K
K
K
--
Y
--
G
Q
--
D
A
--
V
NV
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
H
R
G
K
---
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
Q
-
Y
N
L
T
--
F
----
K
S
P
E
P
T
W
V
T
A
----
E
Q
L
R
-
E
T
Y
-
C
K
W
A
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
-
T
V
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
F
P
G
W
S
-------
16
PsiBlast_PDB
74.70
51%
-68
- C1 -
3QTP
6
ENO1_ENTHI
A:
[8-429]
---
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
-
R
S
C
V
P
S
G
A
-
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
G
H
-----
K
-----
E
---
M
-----
T
-
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
--
Y
--
G
Q
DA
T
N
--
V
--
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
G
---
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
T
K
K
-
Y
D
L
G
-
K
K
IPAD
K
K
D
P
S
L
V
K
D
V
D
G
L
I
A
E
Y
V
-
D
Y
G
-
K
H
----
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
-
H
G
N
F
Q
I
V
G
D
D
L
-
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
I
P
Y
A
G
K
N
W
R
N
-
S
T
A
---
48
PsiBlast_CBE
73.88
51%
-68
- C1 -
3QTP
6
ENO1_ENTHI
B:
[8-429]
---
I
Q
K
V
H
A
R
E
I
L
D
S
R
G
N
P
T
I
E
V
E
I
T
T
G
K
G
M
----------
F
-
R
S
C
V
P
S
G
A
-
S
T
G
V
H
E
A
V
E
L
R
D
G
D
K
K
R
Y
G
G
K
G
V
L
K
A
V
E
N
V
N
T
I
I
G
P
A
L
L
--
G
--
K
N
V
L
N
Q
A
E
L
D
E
M
M
I
K
L
D
G
T
N
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
S
I
C
R
A
A
A
A
E
K
G
L
P
L
Y
K
Y
---
L
A
E
L
T
G
H
-----
K
-----
E
---
M
-----
T
-
M
P
V
P
C
F
N
V
I
N
G
G
A
H
A
G
N
A
L
A
M
Q
E
F
M
I
C
P
T
G
A
T
N
F
H
E
A
L
R
M
A
A
E
T
Y
Q
C
----
L
K
V
V
I
K
A
K
--
Y
--
G
Q
DA
T
N
--
V
--
G
D
E
G
G
F
A
P
N
V
S
G
A
R
E
A
L
D
L
L
V
E
A
I
A
K
A
G
Y
T
G
---
K
I
E
I
A
M
D
C
A
A
S
E
F
Y
N
E
E
T
K
K
-
Y
D
L
G
-
K
K
IPAD
K
K
D
P
S
L
V
K
D
V
D
G
L
I
A
E
Y
V
-
D
Y
G
-
K
H
----
Y
P
I
A
S
I
E
D
P
F
A
E
D
D
W
A
A
W
N
K
F
T
V
E
-
H
G
N
F
Q
I
V
G
D
D
L
-
L
V
T
N
P
A
R
V
Q
M
A
M
D
K
N
A
C
N
S
V
L
I
K
V
N
Q
I
G
T
L
T
E
T
F
K
T
I
K
M
A
Q
E
K
G
W
G
V
M
A
S
H
R
S
G
E
T
E
D
T
F
I
A
D
L
V
V
G
L
N
C
K
Q
I
K
T
G
A
P
C
R
S
E
R
L
C
K
Y
N
Q
L
M
R
I
E
E
E
L
G
N
I
P
Y
A
G
K
N
W
R
N
-
S
T
A
---
119
HHSearch
71.41
48%
-67
- C1 -
2PTZ
5
?
A:
[3-429]
H
M
T
I
Q
K
V
H
G
R
E
V
L
D
S
R
G
N
P
T
V
E
V
E
V
T
T
E
K
G
V
F
R
S
A
V
P
S
G
AS
T
G
V
Y
E
A
C
E
L
R
-
D
-----------
G
D
K
K
R
Y
V
G
K
G
C
L
Q
A
V
K
N
V
N
E
V
I
G
P
A
L
I
--
G
--
R
D
E
L
K
Q
E
E
L
D
T
L
M
L
R
L
D
G
T
P
N
K
G
K
L
G
A
N
A
I
L
G
C
S
M
A
I
S
K
A
A
A
A
A
K
G
V
P
L
Y
R
Y
---
L
A
---
S
L
-----
A
GTK--
E
---
L
-----
R
-
L
P
V
P
C
F
N
V
I
N
G
G
K
H
A
G
N
A
L
P
F
Q
E
F
M
I
A
P
V
K
A
T
S
F
S
E
A
L
R
M
G
S
E
V
Y
H
S
L
R
G
I
I
K
K
K
Y
G
Q
------
D
A
--
V
N
--
V
--
G
D
E
G
G
F
A
P
P
I
K
D
I
N
E
P
L
P
I
L
M
E
A
I
E
E
A
G
--
H
R
G
-
K
F
A
I
C
M
D
C
A
A
S
E
T
Y
D
E
K
K
Q
Q
-
Y
N
L
T
-
F
K
----
S
P
-
E
P
T
W
V
T
A
----
E
Q
L
R
E
T
Y
C
-
K
W
A
-
H
D
Y
P
I
V
S
I
E
D
P
Y
D
Q
D
D
F
A
G
F
A
G
I
T
E
A
L
K
G
K
T
Q
I
V
G
D
D
L
T
V
-
T
N
T
E
R
I
K
M
A
I
E
K
K
A
C
N
S
L
L
L
K
I
N
Q
I
G
T
I
S
E
A
I
A
S
S
K
L
C
M
E
N
G
W
S
V
M
V
S
H
R
S
G
E
T
E
D
T
Y
I
A
D
L
V
V
A
L
G
S
G
Q
I
K
T
G
A
P
C
R
G
E
R
T
A
K
L
N
Q
L
L
R
I
E
E
E
L
G
A
H
A
K
F
G
F
P
G
W
S
-------
67
PsiBlast_CBE
35.34
49%
21
- C1 -
1PDZ
2
ENO_HOMGA
A:
[5-430]
---
I
T
K
V
F
A
R
T
I
F
D
S
R
G
N
P
T
V
E
V
D
L
Y
T
S
K
G
L
----------
F
-
R
A
A
V
P
S
G
A
-
S
T
G
V
H
E
A
L
E
M
R
D
G
D
K
S
K
Y
H
G
K
S
V
F
N
A
V
K
N
V
N
D
V
I
V
P
E
I
I
K
S
G
--
L
K
V
T
Q
Q
K
E
C
D
E
F
M
C
K
L
D
G
T
E
N
K
S
S
L
G
A
N
A
I
L
G
V
S
L
A
I
C
K
A
G
A
A
E
L
G
I
P
L
Y
R
H
I
A
N
L
A
---
N
Y
-----
D
-----
E
---
V
-----
I
-
L
P
V
P
A
F
N
V
I
N
G
G
S
H
A
G
N
K
L
A
M
Q
E
F
M
I
L
P
T
G
A
T
S
F
T
E
A
M
R
M
G
T
E
V
Y
H
H
----
L
K
A
V
I
K
A
R
F-
G
--
L
D
A-
T
A
--
V
--
G
D
E
G
G
F
A
P
N
I
L
N
N
K
D
A
L
D
L
I
Q
E
A
I
K
K
A
G
Y
T
G
K
---
I
E
I
G
M
D
V
A
A
S
E
F
Y
-
K
Q
N
N
I
-
Y
D
L
D
F
K
T
----
A
N
N
D
G
S
Q
K
I
S
----
G
D
Q
L
R
D
M
Y
-
M
E
F
C
K
D
F
P
I
V
S
I
E
D
P
F
D
Q
D
D
W
E
T
W
S
K
M
T
S
--
G
T
T
I
Q
I
V
G
D
D
L
-
T
V
T
N
P
K
R
I
T
T
A
V
E
K
K
A
C
K
C
L
L
L
K
V
N
Q
I
G
S
V
T
E
S
I
D
A
H
L
L
A
K
K
N
G
W
G
T
M
V
S
H
R
S
G
E
T
E
D
C
F
I
A
D
L
V
V
G
L
C
T
G
Q
I
K
T
G
A
P
C
R
S
E
R
L
A
K
Y
N
Q
I
L
R
I
E
E
E
L
G
S
G
A
K
F
A
G
-
K
N
F
-
R
A
P
S
--