@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0610: (2015-12-02 )
MKLLTNANTLKGTIRVPGDKSISHRAIIFGSISQGVTRIVDVLRGEDVLSTIEAFKQMGVLIEDDGEIITIYGKGFAGLTQPNNLLDMGNSGTSMRLIAGVLAGQEFEVTMVGDNSLSKRPMDRIALPLSKMGARISGVTNRDLPPLKLQGTKKLKPIFYHLPVASAQVKSALIFAALQTKGESLIVEKEQTRNHTEDMIRQFGGHLDIKDKEIRLNGGQSLVGQDIRVPGDISSAAFWIVVGLIIPNSHIILENVGINETRTGILDVVSKMGGKIKLSSVDNQVKSATLTVDYSHLQATHISGAMIPRLIDELPIIALLATQAQGTTVIADAQELKVKETDRIQVVVESLKQMGADITATADGMIIRGNTPLHAASLDCHGDHRIGMMIAIAALLVKEGEVDLSGEEAINTSYPNFLEHLEGLVNA
Atome Classification :
(28 SA)
....-.....10........20........30........40........50........60..--...--...70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210----.-----.......220.......230.......240.......250.......260.......270......--.--280..--.......290.......300.......310.......320.......330.......340.......350.......360.......370------...-.-...380.......390...-....400.......410.......420.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKLL-TNANT
L
K
G
T
I
RVPGDKSIS
H
R
A
I
I
F
G
S
I
S
Q
G
V
T
R
I
V
D
V
LRG
E
D
V
L
S
T
I
E
A
F
K
QMG
V
L
IE--DDG--
E
I
I
T
I
YGKGFAGLTQPNN
L
L
DMGNSGT
S
M
R
L
I
A
G
V
LAG
Q
E
F
E
V
T
M
VGDNSLSKR
P
M
D
R
I
AL
P
L
S
K
M
G
A
R
ISGVTNRDLPPLKLQGTKKL
K
P
I
F
Y
HLPV
A
S
A
Q
V
K
S
A
L
I
F
A
A
L
QTKG
E
S
L
I
V
E
K
E
Q
TRN
H
T
E
D
M
I
R
Q
FGGHLDIKD-----
K
-----
E
I
R
LNGG
Q
S
LVGQDIRVPGDISSA
A
F
W
I
V
V
G
L
I
IPN
S
H
I
I
L
E
NVGIN
E
T
R
T
G
I
L
D
V
V
S
KMG
G
K
I
K
L
--S--S--VD--NQVK
S
A
T
L
T
V
D
YSHLQATHIS
G
A
M
I
P
R
L
I
D
EL
P
I
I
A
L
L
ATQAQG
T
T
V
I
A
D
A
Q
E
L
KVKET
D
R
I
Q
V
V
V
E
S
L
K
QMGA
D
I
TATAD
G
M
I
I
RGNTP------
L
H
A
-
A
-
S
LDCHGDH
R
I
G
M
M
I
A
I
A
A
L
-
L
VKEGEVDLSGEEAINTS
Y
P
N
F
L
E
H
L
E
G
L
VNA
2
PsiBlast_PDB
97.90
67%
-120
- C8 -
1RF5
-
AROA_STRPN
A:
[1-426]
M
K
L
K
-
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
K
D
--
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
--
T
--
E
--
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
------
L
H
G
-
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
4
PsiBlast_PDB
96.51
62%
-117
- C8 -
4N3P
11
?
A:
[3-427]
-
K
L
K
-
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
S
S
I
S
V
L
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
K
D
--
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
A
S
I
V
A
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
N
S
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
S
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
E
E
T
L
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
--
T
--
E
--
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
------
L
H
G
-
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
----
P
S
F
F
D
D
L
E
S
L
I
H
G
3
PsiBlast_PDB
96.05
67%
-112
- C8 -
1RF6
2
AROA_STRPN
A:
[1-426]
M
K
L
K
-
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
K
D
--
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
--
T
--
E
--
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
------
L
H
G
-
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
23
PsiBlast_CBE
95.91
67%
-110
- C8 -
1RF6
2
AROA_STRPN
B:
[1-426]
M
K
L
K
-
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
K
D
--
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
--
T
--
E
--
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
------
L
H
G
-
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
22
PsiBlast_CBE
95.84
67%
-109
- C8 -
1RF6
2
AROA_STRPN
C:
[1-426]
M
K
L
K
-
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
K
D
--
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
--
T
--
E
--
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
------
L
H
G
-
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
60
HHSearch
95.61
67%
-111
- C8 -
1RF6
2
AROA_STRPN
A:
[1-426]
M
K
L
K
-
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
K
D
--
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
--
T
--
E
--
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
------
L
H
G
-
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
L
V
A
D
G
-
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
26
PsiBlast_CBE
95.55
67%
-110
- C8 -
1RF4
1
AROA_STRPN
B:
[1-426]
M
K
L
K
-
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
K
D
--
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
--
T
--
E
--
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
------
L
H
G
-
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
24
PsiBlast_CBE
95.44
67%
-111
- C8 -
1RF4
1
AROA_STRPN
D:
[1-426]
M
K
L
K
-
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
K
D
--
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
--
T
--
E
--
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
------
L
H
G
-
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
21
PsiBlast_CBE
95.37
67%
-108
- C8 -
1RF6
2
AROA_STRPN
D:
[1-426]
M
K
L
K
-
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
K
D
--
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
--
T
--
E
--
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
------
L
H
G
-
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
25
PsiBlast_CBE
95.28
67%
-111
- C8 -
1RF4
1
AROA_STRPN
C:
[1-426]
M
K
L
K
-
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
K
D
--
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
--
T
--
E
--
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
------
L
H
G
-
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
1
PsiBlast_PDB
95.08
67%
-110
- C8 -
1RF4
1
AROA_STRPN
A:
[1-426]
M
K
L
K
-
T
N
I
R
H
L
H
G
I
I
R
V
P
G
D
K
S
I
S
H
R
S
I
I
F
G
S
L
A
E
G
E
T
K
V
Y
D
I
L
R
G
E
D
V
L
S
T
M
Q
V
F
R
D
L
G
V
E
I
E
--
D
K
D
--
G
V
I
T
V
Q
G
V
G
M
A
G
L
K
A
P
Q
N
A
L
N
M
G
N
S
G
T
S
I
R
L
I
S
G
V
L
A
G
A
D
F
E
V
E
M
F
G
D
D
S
L
S
K
R
P
M
D
R
V
T
L
P
L
K
K
M
G
V
S
I
S
G
Q
T
E
R
D
L
P
P
L
R
L
K
G
T
K
N
L
R
P
I
H
Y
E
L
P
I
A
S
A
Q
V
K
S
A
L
M
F
A
A
L
Q
A
K
G
E
S
V
I
I
E
K
E
Y
T
R
N
H
T
E
D
M
L
Q
Q
F
G
G
H
L
S
V
D
G
-----
K
-----
K
I
T
V
Q
G
P
Q
K
L
T
G
Q
K
V
V
V
P
G
D
I
S
S
A
A
F
W
L
V
A
G
L
I
A
P
N
S
R
L
V
L
Q
N
V
G
I
N
E
T
R
T
G
I
I
D
V
I
R
A
M
G
G
K
L
E
I
--
T
--
E
--
I
D
--
P
V
A
K
S
A
T
L
I
V
E
S
S
D
L
K
G
T
E
I
C
G
A
L
I
P
R
L
I
D
E
L
P
I
I
A
L
L
A
T
Q
A
Q
G
V
T
V
I
K
D
A
E
E
L
K
V
K
E
T
D
R
I
Q
V
V
A
D
A
L
N
S
M
G
A
D
I
T
P
T
A
D
G
M
I
I
K
G
K
S
A
------
L
H
G
-
A
-
R
V
N
T
F
G
D
H
R
I
G
M
M
T
A
I
A
A
L
-
L
V
A
D
G
E
V
E
L
D
R
A
E
A
I
N
T
S
Y
P
S
F
F
D
D
L
E
S
L
I
H
G
63
HHSearch
88.25
51%
-112
- C8 -
3RMT
9
AROA1_BACHD
A:
[6-433]
K
T
V
I
-
P
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
--
Q
A
E
--
E
R
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
-
G
Q
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
A
M
--
E
--
N
--
E
R
V
Q
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
-----
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
T
P
------
L
K
G
G
V
-
T
V
S
S
H
G
D
H
R
I
G
M
A
M
A
I
A
A
L
-
L
A
E
K
-
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
E
29
PsiBlast_CBE
88.10
50%
-112
- C8 -
3RMT
8
AROA1_BACHD
B:
[8-430]
--
V
I
-
P
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
--
Q
A
E
--
E
R
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
-
G
Q
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
A
M
--
E
--
N
E
R
V
Q
--
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
-----
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
T
P
------
L
K
G
-
G
V
T
V
S
S
H
G
D
H
R
I
G
M
A
-
M
A
I
A
A
-
L
L
A
E
K
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
E
5
PsiBlast_PDB
87.01
50%
-110
- C8 -
3RMT
9
AROA1_BACHD
A:
[8-430]
--
V
I
-
P
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
--
Q
A
E
--
E
R
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
-
G
Q
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
A
M
--
E
--
N
E
R
V
Q
--
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
-----
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
T
P
------
L
K
G
-
G
V
T
V
S
S
H
G
D
H
R
I
G
M
A
-
M
A
I
A
A
-
L
L
A
E
K
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
E
27
PsiBlast_CBE
85.68
50%
-107
- C8 -
3RMT
3
AROA1_BACHD
D:
[8-430]
--
V
I
-
P
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
--
Q
A
E
--
E
R
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
-
G
Q
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
A
M
--
E
--
N
ER
V
Q
--
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
-----
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
T
P
------
L
K
G
-
G
V
T
V
S
S
H
G
D
H
R
I
G
M
A
-
M
A
I
A
A
-
L
L
A
E
K
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
E
28
PsiBlast_CBE
85.65
50%
-108
- C8 -
3RMT
6
AROA1_BACHD
C:
[8-430]
--
V
I
-
P
H
A
K
G
L
K
G
T
I
K
V
P
G
D
K
S
I
S
H
R
A
V
M
F
G
A
L
A
K
G
T
T
T
V
E
G
F
L
P
G
A
D
C
L
S
T
I
S
C
F
Q
K
L
G
V
S
I
E
--
Q
A
E
--
E
R
V
T
V
K
G
K
G
W
D
G
L
R
E
P
S
D
I
L
D
V
G
N
S
G
T
T
T
R
L
I
L
G
I
L
S
T
L
P
F
H
S
V
I
I
G
D
E
S
I
G
K
R
P
M
K
R
V
T
E
P
L
K
S
M
G
A
Q
I
D
G
R
D
H
G
N
L
T
P
L
S
I
R
G
-
G
Q
L
K
G
I
D
F
H
S
P
V
A
S
A
Q
M
K
S
A
I
L
L
A
G
L
R
A
E
G
K
T
S
V
T
E
P
A
K
T
R
D
H
T
E
R
M
L
E
A
F
G
V
N
I
E
K
D
G
-----
L
-----
T
V
S
I
E
G
G
Q
M
L
T
G
Q
H
V
V
V
P
G
D
I
S
S
A
A
F
F
L
V
A
G
A
M
V
P
H
S
R
I
T
L
T
N
V
G
I
N
P
T
R
A
G
I
L
E
V
L
K
Q
M
G
A
T
L
A
M
--
E
--
N
ER
V
Q
--
G
G
E
P
V
A
D
L
T
I
E
T
S
V
L
Q
G
V
E
I
G
G
D
I
I
P
R
L
I
D
E
I
P
I
I
A
V
L
A
T
Q
A
S
G
R
T
V
I
K
D
A
E
E
L
K
V
K
E
T
N
R
I
D
T
V
V
S
E
L
T
K
L
G
A
S
I
H
A
T
D
D
G
M
I
I
E
G
P
T
P
------
L
K
G
-
G
V
T
V
S
S
H
G
D
H
R
I
G
M
A
-
M
A
I
A
A
-
L
L
A
E
K
P
V
T
V
E
G
T
E
A
I
A
V
S
Y
P
S
F
F
D
H
L
D
R
L
K
S
E
6
PsiBlast_PDB
85.49
43%
-112
- C8 -
3ROI
13
AROA_COXBU
A:
[14-423]
----------
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
E
--
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
G
N
--
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
--------------
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
--
T
HY
T
--
E
K
--
N
E
-
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
-------
L
E
G
-
G
-
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
K
-
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
38
PsiBlast_CBE
84.68
43%
-113
- C8 -
3ROI
9
AROA_COXBU
B:
[14-423]
----------
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
E
--
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
G
N
--
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
D
K
-----
Q
-----
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
--
T
HY
T
--
E
K
---
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
-------
L
E
G
-
G
-
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
K
-
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
62
HHSearch
84.49
42%
-96
* C8 *
3SLH
13
AROA_COXBU
A:
[4-431]
M
D
Y
Q
T
I
P
S
Q
G
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
--
V
I
E
DE
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
-
G
-
N
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
D
K
-----
Q
-----
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
--
T
--
H
--
Y
T
E
K
N
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
-------
L
E
G
-
G
-
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
K
G
-
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
8
PsiBlast_PDB
83.75
43%
-102
- C8 -
4EGR
3
AROA_COXBU
A:
[14-423]
----------
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
V
I
E
D
E
--
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
G
N
--
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
--
K
-----
Q
-----
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
--
T
HY
T
--
E
K
----
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
-------
L
E
G
-
G
-
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
K
-
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
9
PsiBlast_PDB
83.32
43%
-98
- C8 -
4ZND
5
AROA_COXBU
A:
[14-423]
----------
L
S
G
E
I
C
V
P
G
D
K
S
I
S
H
R
A
V
L
L
A
A
I
A
E
G
Q
T
Q
V
D
G
F
L
M
G
A
D
N
L
A
M
V
S
A
L
Q
Q
M
G
A
S
I
Q
VI
E
D
E
--
N
I
L
V
V
E
G
V
G
M
T
G
L
Q
A
P
P
E
A
L
D
C
G
N
S
G
T
A
I
R
L
L
S
G
L
L
A
G
Q
P
F
N
T
V
L
T
G
D
S
S
L
Q
R
R
P
M
K
R
I
I
D
P
L
T
L
M
G
A
K
I
D
S
T
G
N
--
V
P
P
L
K
I
Y
G
N
P
R
L
T
G
I
H
Y
Q
L
P
M
A
S
A
Q
V
K
S
C
L
L
L
A
G
L
Y
A
R
G
K
T
C
I
T
E
P
A
P
S
R
D
H
T
E
R
L
L
K
H
F
H
Y
T
L
Q
K
D
K
-----
Q
-----
S
I
C
V
S
G
G
G
K
L
K
A
N
D
I
S
I
P
G
D
I
S
S
A
A
F
F
I
V
A
A
T
I
T
P
G
S
A
I
R
L
C
R
V
G
V
N
P
T
R
L
G
V
I
N
L
L
K
M
M
G
A
D
I
E
V
--
T
H
Y
T
--
E
K
--
N
E
E
P
T
A
D
I
T
V
R
H
A
R
L
K
G
I
D
I
P
P
D
Q
V
P
L
T
I
D
E
F
P
V
L
L
I
A
A
A
V
A
Q
G
K
T
V
L
R
D
A
A
E
L
R
V
K
E
T
D
R
I
A
A
M
V
D
G
L
Q
K
L
G
I
A
A
E
S
L
P
D
G
V
I
I
Q
G
G
T
-------
L
E
G
-
G
-
E
V
N
S
Y
D
D
H
R
I
A
M
A
F
A
V
A
G
T
-
L
A
K
-
G
P
V
R
I
R
N
C
D
N
V
K
T
S
F
P
N
F
V
E
L
A
N
E
V
G
M
N
13
PsiBlast_PDB
81.08
39%
-96
- C8 -
2PQB
1
AROA_AGRSC
A:
[13-438]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
G
--
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
-
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
--
R
--
L
A
--
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
GKGLGN
A
S
G
-
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
17
PsiBlast_PDB
81.04
39%
-97
- C8 -
2GGA
2
AROA_AGRSC
A:
[18-443]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
G
--
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
-
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
--
R
--
L
A
--
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
GKGLGN
A
S
G
-
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
16
PsiBlast_PDB
80.76
39%
-97
- C8 -
2GG6
2
AROA_AGRSC
A:
[18-443]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
G
--
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
-
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
--
R
--
L
A
--
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
GKGLGN
A
S
G
-
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
61
HHSearch
80.24
39%
-97
- C8 -
2PQC
1
AROA_AGRSC
A:
[6-441]
--
T
A
-
R
K
S
S
G
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
G
--
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
E
-
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
-----
D
ADG
V
R
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
--
I
--
N
--
P
R
L
A
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
GKGLGN
A
S
G
-
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
L
-
V
S
E
N
-
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
14
PsiBlast_PDB
80.18
39%
-96
- C8 -
2PQC
1
AROA_AGRSC
A:
[13-438]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
G
--
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
A
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
-
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
--
R
--
L
A
--
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
GKGLGN
A
S
G
-
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
11
PsiBlast_PDB
80.02
39%
-96
- C8 -
2PQD
1
AROA_AGRSC
A:
[13-438]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
G
--
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
-
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
--
R
--
L
A
--
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
GKGLGN
A
S
G
-
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K
12
PsiBlast_PDB
79.93
39%
-94
- C8 -
2GGD
2
AROA_AGRSC
A:
[18-443]
----------
L
S
G
T
V
R
I
P
G
D
K
S
I
S
H
R
S
F
M
F
G
G
L
A
S
G
E
T
R
I
T
G
L
L
E
G
E
D
V
I
N
T
G
K
A
M
Q
A
M
G
A
R
I
R
--
K
E
G
--
D
T
W
I
I
D
G
V
G
N
G
G
L
L
A
P
E
A
P
L
D
F
G
N
A
G
T
G
C
R
L
T
M
G
L
V
G
V
Y
D
F
D
S
T
F
I
G
D
A
S
L
T
K
R
P
M
G
R
V
L
N
P
L
R
E
M
G
V
Q
V
K
S
-
E
D
G
D
R
L
P
V
T
L
R
G
P
K
T
P
T
P
I
T
Y
R
V
P
M
A
S
A
Q
V
K
S
A
V
L
L
A
G
L
N
T
P
G
I
T
T
V
I
E
P
I
M
T
R
D
H
T
E
K
M
L
Q
G
F
G
A
N
L
T
V
E
T
D
ADG
V
R
-----
T
I
R
L
E
G
R
G
K
L
T
G
Q
V
I
D
V
P
G
D
P
S
S
T
A
F
P
L
V
A
A
L
L
V
P
G
S
D
V
T
I
L
N
V
L
M
N
P
T
R
T
G
L
I
L
T
L
Q
E
M
G
A
D
I
E
V
I
N
P
--
R
--
L
A
--
G
G
E
D
V
A
D
L
R
V
R
S
S
T
L
K
G
V
T
V
P
E
D
R
A
P
S
M
I
D
E
Y
P
I
L
A
V
A
A
A
F
A
E
G
A
T
V
M
N
G
L
E
E
L
R
V
K
E
S
D
R
L
S
A
V
A
N
G
L
K
L
N
G
V
D
C
D
E
G
E
T
S
L
V
V
R
G
R
P
D
GKGLGN
A
S
G
-
A
-
A
V
A
T
H
L
D
H
R
I
A
M
S
F
L
V
M
G
--
L
V
S
E
N
P
V
T
V
D
D
A
T
M
I
A
T
S
F
P
E
F
M
D
L
M
A
G
L
G
A
K