@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0641: (2015-12-02 )
MSMIEVSHLQKNFIKTVKAPGLKGAFQSFLRPEKHTFEAVKDLTFDVPKGQILGFIGANGAGKSTTIKMLTGILKPTSGFCRIDGKLPQENRQNYVKDIGVVFGQRTQLWWDLALQETYTVLKEIYDVPDKEFRKRMAFLNEVLELNDFIKDPVRTLSLGQRMRADIAASLLHNPKVLFLDEPTIGLDVSVKDNIRRAITQINQEEETTILLTTHDLSDIEQLCHRIFMIDRGQEIFDGTVSQLKETFGKMKTLSFDLRPGQEHISSSLIGKSEINIKRNDLVLDIQYDSSRYQTADIIQQTLADFSVRDLKMTDADIEDIIRRFYRNEL
Atome Classification :
(20 SA)
-.........10........20........30........40........50........60........70........80.....----...90--.----.....----.---..100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.--------......240-.......250....----...260.------------------------......270.......280.......290------........300....--...310.......320...-....330--------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MS
M
I
E
V
S
H
L
Q
K
N
F
I
K
T
VKAPG
L
K
G
A
F
Q
S
F
LRPE
K
H
T
F
E
A
V
K
D
LTFDVPK
G
Q
I
L
G
F
IGANGAGK
S
T
T
I
K
M
L
T
G
I
LKPTS
G
F
C
R
IDGK----L
P
Q
E
---
N
----
R
Q
N
Y
V
----
K
---
D
I
G
V
V
FGQR
T
Q
L
W
W
D
L
A
L
Q
E
T
Y
T
V
L
K
E
I
YDV
P
D
K
E
F
R
K
R
M
A
F
L
N
E
V
L
E
L
N
D
F
I
K
D
P
V
R
T
L
S
L
G
Q
R
M
R
A
D
I
A
A
S
L
LHN
P
K
V
L
F
L
DEPTI
G
L
D
V
S
V
K
D
N
I
R
R
A
I
T
Q
INQEE
E
T
T
I
L
L
TTH
D
L
S
D
I
E
Q
L
C
H
R
I
F
MIDRG--------
Q
E
I
F
D
G
T
V
S
-
Q
L
K
E
T
FGKM
K
T
L
S
F
----DLRP
G
Q
E
------------------------
H
I
S
S
S
LIGKS
E
I
N
I
KRN
D
L
V
L
D
I
QYDSS-------RY
Q
T
A
D
I
I
Q
Q
T
L
A
DF--SVRDLKMTDA
D
I
E
D
I
I
R
R
F
-YRNEL----------------------------------
55
Fugue
84.76
25%
-80
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
-----------------
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
ELTT
L
S
E
S
---
E
----
L
T
K
A
R
----
R
---
Q
I
G
M
I
F
-
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
--------
E
L
I
E
Q
D
T
V
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
----
I
Q
S
T
L
H
L
DIPEDYQERLQAEPFTDCVPMLRL
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
-------
Q
M
D
Y
A
G
G
V
K
F
G
I
M
L
T
--
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
----------------------------------
41
HHSearch
78.53
31%
-97
* C1 *
3TUI
1
METN_ECOLI
C:
[23-255]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
-----------------
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
----
E
L
T
T
---
L
SESE
L
T
K
A
R
----
R
---
Q
I
G
M
I
F
Q
H
F
-
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
--------
E
L
I
E
Q
D
T
V
S
-
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
----
I
Q
S
T
L
H
L
------------------------
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
-------
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
--
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
V
K
F
-
G
I
M
L
T
----------------------------------
5
PsiBlast_PDB
77.32
32%
-96
- C1 -
3TUI
1
METN_ECOLI
C:
[40-257]
------------------------------------
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
ELTT
L
S
E
S
---
E
----
L
T
K
A
R
----
R
---
Q
I
G
M
I
F
-
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
--------
E
L
I
E
Q
D
T
V
S
----
E
V
F
S
H
P
K
T
P
L
A
----
Q
K
F
I
Q
S
T
------------------------
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-------
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
--
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
----------------------------------
50
HHSearch
77.21
33%
-101
- C1 -
1VPL
2
?
A:
[15-238]
---
A
V
V
V
K
D
L
R
K
R
I
G
K
-
K
--------------------
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
K
----
N
V
V
E
---
E
----
P
H
E
V
R
----
K
---
L
I
S
Y
L
P
E
E
A
-
G
A
Y
R
N
M
Q
G
I
E
Y
L
R
F
V
A
G
F
Y
A
S
S
S
S
E
I
E
E
M
V
E
R
A
T
E
I
A
G
L
G
E
K
I
K
D
R
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
S
Q
-
E
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
--------
T
I
V
E
T
G
T
V
E
-
E
L
K
E
R
Y
K
A
Q
N
I
E
E
V
----
F
E
E
V
V
K
----------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.65
33%
-100
- C1 -
1VPL
2
?
A:
[29-237]
--------------------------------------
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
K
----
N
V
V
E
---
E
----
P
H
E
V
R
----
K
---
L
I
S
-
Y
L
P
E
E
A
G
A
Y
R
N
M
Q
G
I
E
Y
L
R
F
V
A
G
F
Y
A
S
S
S
S
E
I
E
E
M
V
E
R
A
T
E
I
A
G
L
G
E
K
I
K
D
R
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
S
Q
-
E
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
--------
T
I
V
E
T
G
T
V
E
-
E
L
K
E
R
Y
K
A
Q
N
I
E
E
V
----
F
E
E
V
V
K
----------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
76.21
23%
-61
- C1 -
1OXS
23
?
C:
[1-352]
-
M
V
R
I
I
V
K
N
V
S
K
V
F
-------------------
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
----
L
V
A
S
---
N
----
G
K
L
I
V
PPED
R
---
K
I
G
M
V
F
-
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
--------
K
L
V
Q
V
G
K
P
E
-
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
IGEI
N
E
L
E
G
K
V
------------------------
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
-------
D
V
K
L
S
K
D
V
I
K
D
D
S
W
I
--
L
V
G
K
G
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
-
T
I
T
P
L
DSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
24
PsiBlast_CBE
76.11
32%
-95
- C1 -
3TUI
1
METN_ECOLI
H:
[40-257]
------------------------------------
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
ELTT
L
S
E
S
---
E
----
L
T
K
A
R
----
R
---
Q
I
G
M
I
F
-
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
--------
E
L
I
E
Q
D
T
V
S
----
E
V
F
S
H
P
K
T
P
L
A
----
Q
K
F
I
Q
S
T
------------------------
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-------
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
--
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
----------------------------------
6
PsiBlast_PDB
76.06
32%
-97
- C1 -
3TUZ
1
METN_ECOLI
C:
[40-257]
------------------------------------
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
ELTT
L
S
E
S
---
E
----
L
T
K
A
R
----
R
---
Q
I
G
M
I
F
-
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
--------
E
L
I
E
Q
D
T
V
S
----
E
V
F
S
H
P
K
T
P
L
A
----
Q
K
F
I
Q
S
T
------------------------
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-------
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
--
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
----------------------------------
26
PsiBlast_CBE
75.87
32%
-95
- C1 -
3TUI
1
METN_ECOLI
D:
[40-257]
------------------------------------
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
ELTT
L
S
E
S
---
E
----
L
T
K
A
R
----
R
---
Q
I
G
M
I
F
-
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
--------
E
L
I
E
Q
D
T
V
S
----
E
V
F
S
H
P
K
T
P
L
A
----
Q
K
F
I
Q
S
T
------------------------
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-------
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
--
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
----------------------------------
13
PsiBlast_PDB
75.34
24%
-70
- C1 -
2IT1
-
?
A:
[15-304]
------------------------------------
N
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
DVTE
L
P
P
K
---
D
----
R
------------
N
V
G
L
V
F
-
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
D
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
--------
E
I
L
Q
V
G
T
P
D
-
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
----
L
G
N
P
P
M
N
------------------------
F
V
E
A
K
V
E
D
G
K
L
V
I
T
E
K
S
K
L
P
I
P
K
Q
Y
V
E
I
-------
V
K
E
T
G
--
I
T
E
V
I
I
G
F
--
R
P
H
D
A
E
I
V
K
G
E
G
E
G
I
V
G
E
V
-
Y
S
F
E
P
----------------------------------
21
PsiBlast_CBE
75.14
32%
-97
- C1 -
3TUZ
1
METN_ECOLI
H:
[40-257]
------------------------------------
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
ELTT
L
S
E
S
---
E
----
L
T
K
A
R
----
R
---
Q
I
G
M
I
F
-
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
--------
E
L
I
E
Q
D
T
V
S
----
E
V
F
S
H
P
K
T
P
L
A
----
Q
K
F
I
Q
S
T
------------------------
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-------
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
--
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
----------------------------------
43
HHSearch
74.76
28%
-86
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[5-237]
-
D
Y
I
L
K
V
E
E
L
N
Y
N
Y
S
D
G
T
--------------------
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
----
P
I
D
Y
S
R
K
G
----
I
M
K
L
R
----
E
---
S
I
G
I
V
F
Q
D
P
D
N
Q
L
F
S
A
S
V
Y
Q
D
V
S
F
G
A
V
N
M
K
L
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
G
I
E
H
L
K
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
--------
R
V
I
L
Q
G
N
P
K
-
E
V
F
A
E
K
E
V
I
R
K
V
N
L
----
R
L
P
R
I
G
H
------------------------
L
M
E
I
-----------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
73.85
25%
-84
- C1 -
1Z47
1
?
A:
[30-271]
---------------------------------------
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
RVTD
L
P
P
Q
---
K
----
R
------------
N
V
G
L
V
F
-
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
--------
N
V
E
Q
F
G
T
P
E
-
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
----
I
---
G
E
S
------------------------
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
-------
S
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
--
P
A
S
E
R
E
A
H
A
Q
V
V
R
S
A
F
K
G
S
-
Y
S
A
C
W
----------------------------------
54
Fugue
73.83
21%
-69
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
--------------------
P
G
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
----
R
V
T
D
---
L
----
P
P
Q
K
-----
R
---
N
V
G
L
V
F
-
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
R
E
K
R
V
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
--------
N
V
E
Q
F
G
T
P
E
-
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
-------
I
G
E
S
------------------------
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
R
P
K
D
V
E
L
Q
P
A
S
E
R
E
A
HA
Q
V
V
R
S
A
F
K
G
S
Y
S
A
C
W
I
R
T
K
-
D
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R----
25
PsiBlast_CBE
73.65
32%
-88
- C1 -
3TUI
1
METN_ECOLI
G:
[40-257]
------------------------------------
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
ELTT
L
S
E
S
---
E
----
L
T
K
A
R
----
R
---
Q
I
G
M
I
F
-
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
--------
E
L
I
E
Q
D
T
V
S
----
E
V
F
S
H
P
K
T
P
L
A
----
Q
K
F
I
Q
S
T
------------------------
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-------
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
--
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
----------------------------------
19
PsiBlast_PDB
73.32
26%
-93
- C1 -
1OXU
7
?
A:
[14-247]
---------------------------------
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
----
L
V
A
S
---
N
----
G
K
L
I
V
PPED
R
---
K
I
G
M
V
F
-
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
KLVQVGK
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
----
K
V
T
N
E
G
V
------------------------
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
-------
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
--
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
-
D
S
E
E
E
----------------------------------
23
PsiBlast_CBE
73.28
32%
-91
- C1 -
3TUZ
1
METN_ECOLI
D:
[40-257]
------------------------------------
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
ELTT
L
S
E
S
---
E
----
L
T
K
A
R
----
R
---
Q
I
G
M
I
F
-
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
--------
E
L
I
E
Q
D
T
V
S
----
E
V
F
S
H
P
K
T
P
L
A
----
Q
K
F
I
Q
S
T
------------------------
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-------
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
--
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
----------------------------------
20
PsiBlast_PDB
73.01
26%
-91
- C1 -
1OXV
7
?
A:
[14-247]
---------------------------------
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
----
L
V
A
S
---
N
----
G
K
L
I
V
PPED
R
---
K
I
G
M
V
F
-
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
T
N
M
K
M
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
H
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
KLVQVGK
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
----
K
V
T
N
E
G
V
------------------------
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
I
R
P
E
D
V
K
L
S
-------
K
D
V
I
K
D
D
S
W
I
L
V
G
K
G
--
K
V
K
V
I
G
Y
Q
G
G
L
F
R
I
T
I
T
P
L
-
D
S
E
E
E
----------------------------------
22
PsiBlast_CBE
72.94
32%
-91
- C1 -
3TUZ
1
METN_ECOLI
G:
[40-257]
------------------------------------
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
ELTT
L
S
E
S
---
E
----
L
T
K
A
R
----
R
---
Q
I
G
M
I
F
-
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
--------
E
L
I
E
Q
D
T
V
S
----
E
V
F
S
H
P
K
T
P
L
A
----
Q
K
F
I
Q
S
T
------------------------
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
-------
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
--
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
A
G
G
-
V
K
F
G
I
----------------------------------
4
PsiBlast_PDB
72.88
30%
-88
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[23-238]
---------------------------------------
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
K
----
P
I
D
Y
---
S
----
R
K
G
I
M
----
K
L
R
E
S
I
G
I
V
F
Q
D
P
D
N
Q
L
F
S
A
S
V
Y
Q
D
V
S
F
G
A
V
N
M
K
L
P
E
D
E
I
R
K
R
V
D
N
A
L
K
R
T
G
I
E
H
L
K
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
--------
R
V
I
L
Q
G
N
P
----
K
E
V
F
A
E
K
E
V
I
R
K
----
V
N
L
R
L
P
R
------------------------
I
G
H
L
M
E
I
--------------------------------------------------------------------------------------------------------