@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0746: (2015-12-02 )
MFLKEIEMQGFKSFADKTKVEFDQGVTAVVGPNGSGKSNITESLRWALGESSAKSLRGGKMPDVIFAGTENRKPLNYAQVSVTLDNSDHFIENIADEVRVERRIFRNGDSEYLIDGRKVRLRDIHDLFMDTGLGRDSFSIISQGRVEAIFNSKPEERRAIFEEAAGVLKYKTRKKETQSKLEQTQGNLDRLEDIIYELDMQVQPLEKQASIAKRFLVLDEERQGLHLSILIEDILQHQSDLTTVEEKLLTVRKELATYYQQRQSLEDENQSLKQKRHHLSEEIEAKQLALLDVTKLKSDLERQIDLIRLESNQKAEKKEEAGQRLAELEIKAKDCSDQITQKNIELTTLSEKIAQIRSEIVSTESSLERFSTNPDQIIEKLREDFVTLMQEEADTSNALTALLADIENQKQASQAKSQEIQEVSKNLEVLKSNAKVALERFEAAKKNVRQLLSHYQDLGQTLQNLEGEYKNQQSILFDHLDEIKSKQARISSLESILKNHSNFYAGVKSVLQAKDQLGGIIGAVSEHLSFDKHYQTALEIALGGSSQHIIVEDESAAKRSIAFLKKNRQGRATFLPLTTIKPRELAQHYLSKLQSSQGFLGIASELVTYDQRLSNIFKNNLGLTAIFDTVDNANVAARQLNYQVRLVTLDGTELRPGGSYSGGANRQNNTVFIKPELDNLKKELKQAQSKQLIQEKEVATLLEQLKEKQETLAQLKNDGEQARLEEQRADIEYQQLSEKLADLNKLYNGLQLSSGALEQTTSENEKNRLEKELEQFAIKKEELTTSIAQIKEDKDSIQEKVNNLTTLLSEAQLEERDLLNEQKFERANCTRLEITLSEIKRDISNLQTLLSHQDSQLDKEELPRIEKQLLQVNNRRENDEEKLVSLRFELEDCEAALDDLAASLAKEGQKNESLIRQQAQLESQCEQLSQQLMIFSRQLSEDYQMTLDEAKVKANVLEDILMAREQLKSLQAKIKALGPVNIDAIAQFEEVHERLTFLNTQRDDLVHAKNLLLETITDMDDEVKTRFKSTFEAIRHSFKETFVQMFGGGSADLILTEGDLLSAGVDISVQPPGKKIQSLNLMSGGEKALSALALLFAIIRVKTIPFVILDEVEAALDEANVKRFGDYLNRFDKSSQFIVVTHRKGTMSAADSIYGVTMQESGVSKIVSVKLKEAQEMTN
Atome Classification :
(20 SA)
--.........-10........20-....-....30........40........50........60........70........80........90........100.......110.......120.......130.....-..140.......150.......160......--.170........180.......190.......200.......210.......220----.........230.--------......240--........250.........260..----....------------------.270.......280.......290.......300....-..--..310.......320....---...330.......340.......350........360.......370.......380.......390.......400....--...410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530........540...-....550.......560....-...570.......580.......590.......--600.......610........620.......630.......640.......650.......660.......670-.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050..-..-.-.1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--M
F
L
K
E
I
E
M
Q
-
G
F
K
S
F
A
D
K
T
K
V
E
-FDQG-
V
T
A
V
VGPNGSG
K
S
N
I
T
E
S
L
R
W
A
LGES
S
A
K
SLRGGKMP
D
V
I
F
AGTENRKP
L
N
Y
A
Q
V
S
V
T
LDNS
D
H
F
I
E
N
I
A
D
E
V
R
V
E
R
R
I
FRNGDS
E
Y
L
IDG
R
K
V
R
L
R
D
I
H
D
L
F
M
DTGLGR
D
S
-
F
S
I
I
SQGR
V
E
A
I
FNSK
P
E
E
R
R
A
I
F
E
E
A
A
G
V
L
--
K
Y
-KT
R
K
K
E
T
Q
S
K
L
E
Q
TQG
N
L
D
R
L
E
D
I
I
Y
E
LDMQVQ
P
L
E
K
Q
A
S
I
A
K
R
F
L
V
LDE------ERQGL
H
L
S
I
L
I
E
D
--------
I
L
Q
HQS
D
L
---
T
T
V
E
E
K
L
L
T
--
V
R
K
E
L
A
T
Y
Y
Q
Q
R
QS----LE
D
E
------------------
N
Q
S
L
K
Q
K
R
H
H
L
S
E
E
I
E
A
K
Q
L
A
L
L
D
V
T
K
L
K
S
D
L
E
-RQ
I
D
-
L
I
--
R
LESNQK
A
E
K
K
E
E
A
G
Q
R
L
A
---
E
L
E
I
K
AKDCS
D
Q
I
T
Q
KNI
E
L
T
T
L
S
E
-
K
I
A
Q
I
R
S
E
I
V
S
T
E
S
S
L
E
RFST
N
P
D
Q
I
I
E
K
L
R
E
D
F
V
T
L
M
Q
EEAD
T
S
N
A
L
T
A
L
L
A
D
I
--
E
N
Q
K
Q
A
S
Q
A
K
S
Q
E
I
Q
E
V
S
K
N
L
E
V
L
KSN
A
K
V
A
L
E
R
F
E
A
A
K
K
N
V
R
Q
L
L
S
H
Y
Q
D
L
G
Q
T
L
Q
N
L
E
G
EYKN
Q
Q
S
I
L
F
D
H
L
D
E
I
K
S
K
Q
A
R
I
S
S
L
E
S
I
L
K
NHS
N
F
Y
A
G
V
K
S
V
L
Q
A
K
D
QL
G
G
I
I
G
A
V
S
E
HL
S
F
-
D
K
H
Y
Q
T
A
L
E
I
A
LGGS-S
Q
H
I
I
VEDES
A
A
K
R
S
I
A
F
L
KK-NRQG
R
A
T
F
L
P
LTTI
K
P
R
E
L
A
Q
H
Y
L
S
K
L
Q
SSQG
F
--
L
G
I
A
S
E
L
V
T
Y
D
Q
-
R
L
S
N
I
F
KNNLG
L
T
A
I
F
DTVDNAN
V
A
A
R
Q
L
N
Y
Q
V
R
L
V
T
LDGTELRPGGSYSGGANRQN
N
T
V
F
-
I
KP
E
L
D
N
L
K
K
E
L
K
Q
A
Q
S
K
Q
L
I
Q
E
K
E
V
A
T
L
L
E
Q
L
K
E
K
Q
E
T
L
A
Q
L
KND
G
E
Q
A
R
L
E
E
Q
RADI
E
Y
Q
Q
L
S
E
K
L
A
D
L
N
K
L
Y
N
G
L
QLSSGALEQTTSE
N
E
K
N
R
L
E
K
E
L
E
Q
F
A
I
K
K
E
E
L
T
T
S
I
A
Q
I
K
E
D
K
D
S
I
Q
E
K
V
N
N
L
T
T
L
L
S
E
A
Q
L
E
E
R
D
L
L
N
E
Q
K
FERAN
C
T
R
L
E
I
T
L
S
E
I
K
R
D
I
S
N
L
Q
T
L
L
S
HQDSQL
D
K
E
E
L
P
R
I
E
K
Q
L
L
Q
VNNRREN
D
E
E
K
L
V
S
L
R
F
E
L
E
D
C
E
A
A
L
D
D
L
A
A
S
L
A
KEGQ
K
N
E
S
L
I
R
Q
Q
A
Q
L
E
S
Q
C
E
Q
L
S
Q
Q
L
M
I
F
S
R
Q
LS
E
D
Y
Q
M
T
L
D
E
A
K
V
K
A
N
V
L
E
D
I
L
M
A
R
E
Q
L
K
S
L
Q
A
K
I
K
ALGPV
N
I
D
A
I
A
Q
F
E
E
V
H
E
R
L
T
F
LNTQR
D
D
L
V
H
A
K
N
L
L
L
E
T
ITDM
D
D
E
V
K
T
R
F
K
S
T
F
E
A
I
R
H
S
F
K
E
T
F
V
Q
M
FGGGS
A
D
L
I
L
-TE-G-DLLSAG
V
D
I
S
VQPPGK
K
I
Q
S
L
NLMSG
G
E
K
A
L
S
A
L
A
L
L
F
A
I
I
RVKTI
P
F
V
I
L
D
E
V
E
A
A
L
D
E
A
N
V
K
R
F
G
D
Y
L
N
R
FDKSS
Q
F
I
V
V
T
HRKGTMSAAD
S
I
Y
G
V
T
MQESGV
S
K
I
V
S
V
K
L
K
E
A
Q
E
MTN
75
HHSearch
79.72
60%
-16
- C3 -
3ZGX
-
SMC_BACSU
A:
[1021-1175]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
E
E
M
D
E
E
M
T
K
R
F
N
D
T
F
V
Q
I
R
S
H
F
D
Q
V
F
R
S
L
F
G
G
G
R
A
E
L
R
L
-
T
D
P
N
-
D
L
L
H
S
G
V
E
I
I
A
Q
P
P
G
K
K
L
Q
N
L
N
L
L
S
G
G
E
R
A
L
T
A
I
A
L
L
F
S
I
L
K
V
R
P
V
P
F
C
V
L
D
E
V
E
A
A
L
D
E
A
N
V
F
R
F
A
Q
Y
L
K
K
Y
S
S
D
T
Q
F
I
V
I
T
H
R
K
G
T
M
E
E
A
D
V
L
Y
G
V
T
M
----
V
S
K
V
I
S
-----------
86
Fugue
76.50
30%
-10
- C1 -
1E69
-
?
A:
[1-1164]
--
M
R
L
K
K
L
Y
L
K
-
G
F
K
S
F
G
R
P
S
L
I
G
-
F
S
D
R
-
V
T
A
I
V
G
P
N
G
S
G
K
S
N
I
I
D
A
I
K
W
V
F
G
E
K
F
----------
D
M
I
F
A
G
S
E
N
L
P
P
A
G
S
A
Y
V
E
L
V
F
E
E
N
G
-------
E
E
I
T
V
A
R
E
L
K
R
T
G
E
N
T
Y
Y
L
N
G
S
P
V
R
L
K
D
I
R
D
R
F
A
G
T
G
L
G
V
D
F
-
Y
S
I
V
G
Q
G
Q
I
D
R
I
V
N
A
Y
Q
R
V
N
E
S
F
N
R
F
I
S
L
L
F
--
F
G
G
E
G
R
L
E
I
S
I
R
K
P
G
R
R
D
Q
K
L
S
L
L
S
G
G
E
K
A
L
V
G
L
A
L
L
F
A
L
M
E
I
K
P
S
P
F
Y
V
L
D
E
VDSPLD
D
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
T
Q
F
I
V
I
T
H
N
K
I
V
---
M
E
A
A
D
L
L
H
G
--
V
T
M
V
N
G
V
S
A
I
V
P
V
E
----
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
HHSearch
70.41
52%
39
- C3 -
1E69
-
?
A:
[1070-1164]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
K
L
S
L
L
S
G
G
E
K
A
L
V
G
L
A
L
L
F
A
L
M
E
I
K
P
S
P
F
Y
V
L
D
E
V
D
S
P
L
D
D
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
T
Q
F
I
V
I
T
H
N
K
I
V
M
E
A
A
D
L
L
H
G
V
T
M
V
N
-
G
V
S
A
I
V
P
V
E
V
--------
95
Fugue
60.71
21%
35
* C1 *
1E69
-
?
A:
[1-1164]
MR
L
K
K
L
Y
L
K
G
F
K---
S
F
G
R
P
S
L
I
G
-
F
S
D
-
R
V
T
A
I
V
G
P
N
G
S
G
K
S
N
I
I
D
A
I
K
W
V
F
G
E
----------
K
F
D
M
I
F
A
G
S
E
N
L
P
P
A
G
S
A
Y
V
E
L
V
F
E
E
N
G
-------
E
E
I
T
V
A
R
E
L
K
R
T
--------
G
E
N
T
Y
Y
L
N
---
G
S
P
V
-----
R
L
-
K
D
I
R
D
R
F
A
--------------
G
T
G
L
G
V
D
F
Y
-----
S
I
V
G
Q
G
Q
I
D
R
I
V
N
-------
A
Y
Q
R
V
N
E
S
F
N
R
F
I
S
L
L
F
F
G
--
G
E
G
R
L
-------------
E
I
S
I
R
K
P
-
G
R
--------
R
D
Q
K
L
S
L
L
---
S
G
G
E
K
A
L
V
G
--
L
A
L
L
F
A
L
M
E
I
K
P
--SP
F
Y
V
L
D
E
VDSPLD------------
D
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
T
--
Q
F
I
V
I
T
H
N
K
-
I
V
M
-
E
A
A
D
L
L
H
--
G
V
T
M
V
N
G
V
S
A
I
V
P
V
E
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Fugue
57.47
31%
-40
- C4 -
1GXJ
-
?
A:
[498-658]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
-
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
-
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
-
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
S
---
F
N
R
I
S
G
L
E
N
E
R
G
F
--
V
G
Y
A
V
D
L
V
K
F
P
S
-
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
57.08
29%
-40
- C4 -
1GXJ
-
?
A:
[498-658]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
-
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
-
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
-
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
---
S
F
N
R
I
S
G
L
E
N
E
R
G
F
--
V
G
Y
A
V
D
L
V
K
F
P
S
-
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
55.25
29%
-40
- C4 -
1GXK
-
?
A:
[501-658]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
-
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
-
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
-
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
---
S
F
N
R
I
S
G
L
E
N
E
R
G
F
--
V
G
Y
A
V
D
L
V
K
F
P
S
-
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
HHSearch
53.42
31%
-31
- C4 -
1GXJ
-
?
A:
[512-658]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
-
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
-
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
-
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
S
F
N
R
---
I
S
G
L
E
N
E
R
G
F
--
V
G
Y
A
V
D
L
V
K
F
P
S
-
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
51.82
28%
-31
- C4 -
1GXL
-
?
A:
[489-679]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
R
D
M
R
E
Y
R
G
F
S
R
A
V
R
A
V
F
E
E
K
E
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
-
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
-
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
-
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
---
S
F
N
R
I
S
G
L
E
N
E
R
G
F
--
V
G
Y
A
V
D
L
V
K
F
P
S
-
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
E
R
S
S
N
V
F
E
R
R
I
K
L
K
H
L
E
Q
E
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
50.49
47%
-32
- C3 -
1XEX
1
?
B:
[4-158]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
N
V
F
M
R
T
F
E
A
I
S
R
N
F
S
E
I
F
A
K
L
S
P
G
G
S
A
R
L
I
L
-
E
N
----
P
F
S
G
G
L
E
I
E
A
K
P
A
G
K
D
V
K
R
I
E
A
M
S
G
G
E
K
A
L
T
A
L
A
F
V
F
A
I
Q
K
F
K
P
A
P
F
Y
L
F
D
Q
I
D
A
H
L
D
D
A
N
V
K
R
V
A
D
L
I
K
E
S
S
K
E
S
Q
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
K
I
I
G
V
S
M
R
D
-
G
V
S
K
V
V
S
L
S
L
E
K
A
M
K
I
L
E
3
PsiBlast_PDB
49.51
46%
-34
- C3 -
3KTA
1
?
B:
[4-159]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
K
N
V
F
M
R
T
F
E
A
I
S
R
N
F
S
E
I
F
A
K
L
S
P
G
G
S
A
R
L
I
L
E
N
P
-
E
-
D
P
F
S
G
G
L
E
I
E
A
K
P
A
G
K
D
V
K
R
I
E
A
M
S
G
G
E
K
A
L
T
A
L
A
F
V
F
A
I
Q
K
F
K
P
A
P
F
Y
L
F
D
E
I
D
A
H
L
D
D
A
N
V
K
R
V
A
D
L
I
K
E
S
S
K
E
S
Q
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
K
I
I
G
V
S
M
R
D
-
G
V
S
K
V
V
S
L
S
L
E
K
A
M
K
I
L
E
73
HHSearch
49.25
49%
-29
- C3 -
3KTA
1
?
B:
[6-158]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
V
F
M
R
T
F
E
A
I
S
R
N
F
S
E
I
F
A
K
L
S
P
G
G
S
A
R
L
I
L
-
E
N
P
E
-
D
P
F
S
G
G
L
E
I
E
A
K
P
A
G
K
D
V
K
R
I
E
A
M
S
G
G
E
K
A
L
T
A
L
A
F
V
F
A
I
Q
K
F
K
P
A
P
F
Y
L
F
D
E
I
D
A
H
L
D
D
A
N
V
K
R
V
A
D
L
I
K
E
S
S
K
E
S
Q
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
K
I
I
G
V
S
M
R
D
-
G
V
S
K
V
V
S
L
S
L
E
K
A
M
K
I
L
E
8
PsiBlast_PDB
49.02
30%
-1
- C4 -
4U4P
-
?
A:
[50-232]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
A
S
L
I
S
V
K
D
T
S
A
T
T
A
L
E
L
V
A
G
E
R
-
L
Y
N
V
V
V
D
T
E
V
T
G
K
K
L
L
E
--
R
G
-
E
L
K
R
R
Y
T
I
I
P
L
N
K
I
S
A
R
C
I
A
P
E
T
L
R
V
A
Q
N
L
V
G
P
DN
V
H
V
A
L
S
L
V
E
Y
K
P
-
E
L
Q
K
A
M
E
F
V
F
G
T
T
F
V
C
D
N
M
D
N
A
K
K
V
A
F
D
K
R
I
M
T
R
T
V
T
L
G
G
D
V
F
D
P
H
G
T
L
S
G
G
A
R
S
Q
A
A
S
I
L
-
T
K
------
F
Q
E
L
K
D
V
Q
D
E
L
R
I
K
E
N
E
L
R
A
L
-------
E
E
E
L
A
G
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
HHSearch
48.92
23%
-20
* C4 *
2WD5
-
SMC3_MOUSE
B:
[527-670]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
N
G
Y
H
G
I
V
M
N
N
F
E
C
-
E
P
A
F
Y
T
C
V
E
V
T
A
G
N
R
-
L
F
Y
H
I
V
D
S
D
E
V
S
T
K
I
L
M
E
F
N
K
M
N
L
P
G
E
V
T
F
L
P
L
N
K
L
D
V
R
D
T
A
------
Y
P
-
E
T
N
D
--
A
I
P
M
I
S
K
L
R
Y
N
P
-
R
F
D
K
A
F
K
H
V
F
G
K
T
L
I
C
R
S
M
E
V
S
T
Q
L
A
R
A
--
F
T
M
D
C
I
T
L
E
G
D
Q
V
S
H
R
G
A
L
T
G
G
Y
Y
D
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
HHSearch
48.45
31%
-22
- C4 -
1GXL
-
?
A:
[512-659]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
P
G
L
V
D
V
V
S
N
L
I
E
V
-
D
E
K
Y
S
L
A
V
S
V
L
L
G
G
T
-
A
Q
N
I
V
V
R
N
V
D
T
A
K
A
I
V
E
F
L
K
Q
-
N
E
A
G
R
V
T
I
L
P
L
D
L
I
D
G
S
F
N
R
---
I
S
G
L
E
N
E
R
G
F
--
V
G
Y
A
V
D
L
V
K
F
P
S
-
D
L
E
V
L
G
G
F
L
F
G
N
S
V
V
V
E
T
L
D
D
A
I
R
M
K
K
K
Y
R
L
N
T
R
I
A
T
L
D
G
E
L
I
S
G
R
G
A
I
T
G
G
R
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
48.44
48%
-35
- C3 -
1XEW
-
?
Y:
[1012-1163]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
F
M
R
T
F
E
A
I
S
R
N
F
S
E
I
F
A
K
L
S
P
G
G
S
A
R
L
I
L
-
E
N
-
P
E
D
P
F
S
G
G
L
E
I
E
A
K
P
A
G
K
D
V
K
R
I
E
A
M
S
G
G
E
K
A
L
T
A
L
A
F
V
F
A
I
Q
K
F
K
P
A
P
F
Y
L
F
D
E
I
D
A
H
L
D
D
A
N
V
K
R
V
A
D
L
I
K
E
S
S
K
E
S
Q
F
I
V
I
T
L
R
D
V
M
M
A
N
A
D
K
I
I
G
V
S
M
---
G
V
S
K
V
V
S
L
S
L
E
K
A
M
K
I
--
88
Fugue
47.99
16%
17
- C1 -
4UX3
2
SMC3_YEAST
A:
[3-527]
---
Y
I
K
R
V
I
I
K
-
G
F
K
T
Y
R
N
E
T
I
I
D
N
F
S
P
H
-
Q
N
V
I
I
G
S
N
G
S
G
K
S
N
F
F
A
A
I
R
F
V
L
S
D
D
Y
-
S
N
L
K
R
E
E
R
Q
G
L
I
H
Q
G
S
G
G
S
V
M
S
A
S
V
E
I
-------------------
V
I
R
R
T
V
G
L
K
K
D
D
Y
Q
L
N
D
R
N
V
T
K
G
D
I
V
R
M
L
E
T
A
G
F
S
M
N
N
P
Y
N
I
V
P
Q
G
K
I
V
A
L
T
N
A
K
D
K
E
R
L
Q
L
L
E
D
V
V
G
A
K
--
S
F
-
E
V
K
L
K
A
S
L
K
K
M
E
E
T
E
Q
K
K
I
Q
I
N
K
E
M
G
E
L
N
S
K
L
S
E
M
E
Q
E
R
K
E
L
E
K
Y
N
E
L
E
R
------
N
R
K
I
Y
Q
F
T
L
Y
D
R
E
--------
L
N
E
V
I
N
Q
M
ETS
D
Q
L
L
Q
R
L
N
D
--
M
N
T
E
I
S
G
L
K
N
V
N
K
R
----
A
F
E
N
------------------
F
K
K
F
N
E
R
R
K
D
L
A
E
R
A
S
E
L
D
E
S
K
D
S
I
Q
D
L
I
V
K
L
K
Q
Q
K
V
N
-
A
V
--
D
S
T
F
Q
K
V
S
E
N
F
E
A
V
F
E
R
L
V
PR
G
T
A
K
L
I
I
H
S
I
S
V
S
F
N
S
K
Q
N
E
Q
L
H
V
E
Q
L
S
G
G
Q
K
T
V
C
A
I
A
L
I
L
A
I
Q
M
V
D
P
A
S
F
Y
L
F
D
E
I
D
A
A
L
------
D
K
Q
Y
R
T
A
V
A
T
L
L
K
E
L
SK
N
A
Q
F
I
C
T
T
F
R
T
D
M
L
Q
V
A
D
K
F
F
R
V
K
Y
E
N
K
I
S
T
V
I
E
V
N
R
E
E
A
I
G
F
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
47.06
25%
-21
- C4 -
2WD5
-
SMC1A_MOUSE
A:
[513-658]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
V
Y
G
R
L
I
D
L
C
Q
P
T
Q
K
K
Y
Q
I
A
V
T
K
V
L
G
K
N
-
M
D
A
I
I
V
D
S
E
K
T
G
R
D
C
I
Q
Y
I
K
E
-
Q
R
G
E
P
E
T
F
L
P
L
D
Y
L
E
V
K
P
T
D
E
-----
K
L
R
E
L
K
G
--
A
K
L
V
I
D
V
I
R
Y
E
P
P
H
I
K
K
A
L
Q
Y
A
C
G
N
A
L
V
C
D
N
V
E
D
A
R
R
I
A
F
G
G
H
Q
R
H
K
T
V
A
L
D
G
T
L
F
Q
K
S
G
V
I
S
G
G
A
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
46.88
26%
-21
- C4 -
2WD5
-
SMC3_MOUSE
B:
[530-666]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
H
G
I
V
M
N
N
F
E
C
-
E
P
A
F
Y
T
C
V
E
V
T
A
G
N
R
L
F
Y
H
I
V
D
S
D
E
V
S
T
K
I
L
M
E
F
N
K
M
-
N
L
P
G
E
V
T
F
L
P
L
N
K
L
D
V
R
D
T
A
------
Y
P
E
T
N
D
A
--
I
P
M
I
S
K
L
-
R
Y
N
P
-
R
F
D
K
A
F
K
H
V
F
G
K
T
L
I
C
R
S
M
E
V
S
T
Q
L
A
R
A
--
F
T
M
D
C
I
T
L
E
G
D
Q
V
S
H
R
G
A
L
T
G
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Fugue
46.85
15%
20
- C1 -
2O5V
1
RECF_DEIRA
A:
[2-359]
GD
V
R
L
S
A
L
S
T
L
-
N
Y
R
N
L
A
P
G
-
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--------
S
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-----------
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------
E
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A
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A
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---
K
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L
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----
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GSTVTGPHRDDL
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---
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--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------