@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0783: (2015-12-03 )
MSRKPFIAGNWKMNKNPEEAKAFIEAVASKLPSSELVEAGIAAPALTLSTVLEAAKGSELKIAAQNSYFENSGAFTGENSPKVLAEMGTDYVVIGHSERRDYFHETDQDINKKAKAIFANGLTPIICCGESLETYEAGKAVEFVGAQVSAALAGLSEEQVSSLVIAYEPIWAIGTGKSATQDDAQNMCKAVRDVVAADFGQAVADKVRVQYGGSVKPENVAEYMACPDVDGALVGGASLEAESFLALLDFVK
Atome Classification :
(56 SA)
.........10........20......-..-30...--..--...40.......---.50...--...---..60.--.......70........80........90........100.......110.......120.......130.......140.......150.......160.........170.......180.......190.......200.......210.......220.......230.......240.......250
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSRK
P
F
I
AGNWKMNK
N
P
E
E
A
K
A
F
I
E
A
V
-
A
S
-KL
P
S
S
--
E
L
--
V
E
AGIAA
P
A
L
T
L
---
S
T
V
L
E
A--AKG---S
E
L
K
I
--
A
AQNSYFENSGAFTGENS
P
K
V
L
A
EMGT
D
Y
V
V
I
G
H
S
E
R
R
D
YFHET
D
Q
D
I
N
K
K
A
K
A
I
FANG
L
T
P
I
I
CCGESL
E
T
YEAGK
A
V
E
F
V
G
A
Q
V
S
A
A
L
AGL
S
E
E
Q
V
--
S
S
L
V
I
A
YE
P
I
W
A
IGTGKSA
T
Q
D
D
A
Q
N
M
C
K
A
V
R
D
V
V
A
A
D
F
G
Q
A
V
A
D
K
V
R
V
Q
YGGSV
K
P
E
N
V
A
E
Y
MACPDVDGALVGGASL
E
A
E
S
F
L
A
L
L
D
FVK
3
PsiBlast_PDB
91.69
58%
-88
- C3 -
3UWV
5
TPIS_STAAR
A:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
P
D
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
6
PsiBlast_PDB
91.57
58%
-88
- C3 -
3UWZ
1
TPIS_STAAR
A:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
P
D
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
4
PsiBlast_PDB
91.29
58%
-90
- C3 -
3UWW
3
TPIS_STAAR
A:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
P
D
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
2
PsiBlast_PDB
91.24
58%
-87
- C3 -
3UWU
2
TPIS_STAAR
A:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
P
D
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
5
PsiBlast_PDB
90.78
58%
-89
- C3 -
3UWY
-
TPIS_STAAR
A:
[2-253]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
P
D
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
25
PsiBlast_CBE
90.75
58%
-90
- C3 -
3UWU
1
TPIS_STAAR
B:
[10-260]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
P
D
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
DAL
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
24
PsiBlast_CBE
90.72
58%
-86
- C3 -
3UWV
4
TPIS_STAAR
B:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
P
D
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
23
PsiBlast_CBE
90.63
58%
-88
- C3 -
3UWW
3
TPIS_STAAR
B:
[10-260]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
P
D
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
-
21
PsiBlast_CBE
90.56
58%
-88
- C3 -
3M9Y
3
TPIS_STAAR
B:
[3-254]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
P
D
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
101
HHSearch
90.01
54%
-88
- C3 -
2BTM
1
TPIS_GEOSE
A:
[1-249]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
P
P
A
--
D
E
--
V
I
S
V
V
C
A
P
F
L
F
L
---
D
R
L
V
Q
A
--
A
D
G
---
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
--
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
106
HHSearch
89.86
59%
-87
- C3 -
3M9Y
2
TPIS_STAAR
A:
[1-254]
S
M
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
-
L
P
D
-
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
---
D
A
L
T
T
A
--
V
K
E
GKA
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
--
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
1
PsiBlast_PDB
89.80
58%
-88
- C3 -
3M9Y
2
TPIS_STAAR
A:
[3-254]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
P
D
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
--
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
22
PsiBlast_CBE
89.68
58%
-87
- C3 -
3UWZ
2
TPIS_STAAR
B:
[10-261]
--
R
T
P
I
I
A
G
N
W
K
M
N
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
T
--
L
P
D
S
--
K
E
--
V
E
S
V
I
C
A
P
A
I
Q
L
D
A
L
T
T
A
V
K
E
--
G
K
A
---
Q
G
L
E
I
--
G
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
--
K
S
V
V
I
A
Y
E
P
I
W
A
I
---
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
S
K
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
G
A
K
122
Fugue
89.16
53%
-87
- C3 -
2BTM
1
TPIS_GEOSE
A:
[1-250]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
P
P
A
--
D
E
--
V
I
S
V
V
C
A
P
F
L
F
L
---
D
R
L
V
Q
A
A
D--
G
---
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
--
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
9
PsiBlast_PDB
89.16
52%
-92
- C3 -
4Y8F
5
?
A:
[5-251]
--
R
T
P
I
I
A
G
N
W
K
M
H
Y
T
I
D
E
A
V
K
L
V
E
E
L
-
K
P
-
L
V
K
D
A
--
K
C
---
E
V
V
V
C
P
T
F
V
C
L
---
D
A
V
K
K
A
--
V
E
G
---
T
N
I
K
V
--
G
A
Q
N
M
H
F
E
E
K
G
A
F
T
G
E
I
A
P
R
M
L
E
A
M
N
I
D
Y
V
I
I
G
H
S
E
R
R
E
Y
F
N
E
T
D
E
T
C
N
K
K
V
K
A
A
F
A
H
N
L
T
P
I
L
C
C
G
E
T
L
E
Q
R
E
N
G
T
T
N
D
V
I
K
A
Q
I
T
A
D
L
E
G
L
T
K
E
Q
A
--
E
K
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
T
A
T
S
D
Q
A
N
E
T
I
A
A
I
R
A
M
V
A
E
M
F
G
Q
E
V
A
D
K
V
R
I
Q
Y
G
G
S
V
K
P
N
T
I
A
E
Q
M
A
K
S
D
I
D
G
A
L
V
G
G
A
S
L
V
A
A
D
F
A
Q
I
V
N
Y
--
7
PsiBlast_PDB
88.92
54%
-84
- C3 -
2BTM
1
TPIS_GEOSE
A:
[1-247]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
P
P
A
--
D
E
--
V
I
S
V
V
C
A
P
F
L
F
L
---
D
R
L
V
Q
A
--
A
D
G
---
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
--
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
26
PsiBlast_CBE
88.46
54%
-83
- C3 -
2BTM
1
TPIS_GEOSE
B:
[1-247]
--
R
K
P
I
I
A
G
N
W
K
M
N
G
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
P
P
A
--
D
E
--
V
I
S
V
V
C
A
P
F
L
F
L
---
D
R
L
V
Q
A
--
A
D
G
---
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
--
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
104
HHSearch
87.40
44%
-89
- C3 -
1B9B
1
PGKT_THEMA
A:
[2-250]
-
T
R
K
L
I
L
A
G
N
W
K
M
H
K
T
I
S
E
A
K
K
F
V
S
L
L
-
V
N
-
E
L
H
D
V
--
K
E
--
F
E
I
V
V
C
P
P
F
T
A
L
---
S
E
V
G
E
I
--
L
S
G
---
R
N
I
K
L
--
G
A
Q
N
V
F
Y
E
D
Q
G
A
F
T
G
E
I
S
P
L
M
L
Q
E
I
G
V
E
Y
V
I
V
G
H
S
E
R
R
R
I
F
K
E
D
D
E
F
I
N
R
K
V
K
A
V
L
E
K
G
M
T
P
I
L
C
V
G
E
T
L
E
E
R
E
K
G
L
T
F
C
V
V
E
K
Q
V
R
E
G
F
Y
G
L
D
K
E
E
A
--
K
R
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
T
P
Q
Q
A
Q
E
V
H
A
F
I
R
K
L
L
S
E
M
Y
D
E
E
T
A
G
S
I
R
I
L
Y
G
G
S
I
K
P
D
N
F
L
G
L
I
V
Q
K
D
I
D
G
G
L
V
G
G
A
S
L
K
E
-
S
F
I
E
L
A
R
I
M
R
8
PsiBlast_PDB
86.77
53%
-84
- C3 -
1BTM
1
TPIS_GEOSE
A:
[1-247]
--
R
K
P
I
I
A
G
N
W
K
M
H
K
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
P
P
A
--
D
E
--
V
I
S
V
V
C
A
P
F
L
F
L
---
D
R
L
V
Q
A
--
A
D
G
---
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
--
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
P
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
10
PsiBlast_PDB
86.67
50%
-86
- C3 -
4Y9A
-
?
A:
[7-258]
--
R
T
P
L
M
A
G
N
W
K
M
N
L
N
H
L
E
A
I
A
H
V
Q
K
L
-
A
F
-
A
L
A
D
K
--
D
Y
D
A
V
E
V
A
V
L
A
P
F
T
D
L
---
R
S
V
Q
T
L
--
V
D
G
---
D
K
L
K
I
K
Y
G
A
Q
D
I
S
A
H
D
G
G
A
Y
T
G
E
I
S
G
P
M
L
A
K
L
K
C
T
Y
V
A
V
G
H
S
E
R
R
Q
Y
H
A
E
T
D
E
I
V
N
A
K
V
K
A
A
Y
K
H
G
L
T
P
I
L
C
V
G
E
E
L
D
V
R
E
A
G
N
H
V
E
H
T
L
A
Q
V
E
G
G
L
K
D
L
A
A
E
Q
A
--
E
S
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
V
C
G
A
D
D
A
Q
E
V
C
A
A
I
R
G
K
L
A
E
L
Y
S
Q
E
L
A
D
K
V
R
I
Q
Y
G
G
S
V
K
S
G
N
V
A
E
I
M
A
K
P
D
I
D
G
A
L
V
G
G
A
S
L
D
S
D
E
F
V
K
I
V
R
F
R
D
27
PsiBlast_CBE
86.19
53%
-80
- C3 -
1BTM
1
TPIS_GEOSE
B:
[1-247]
--
R
K
P
I
I
A
G
N
W
K
M
H
K
T
L
A
E
A
V
Q
F
V
E
D
V
-
K
G
-
H
V
P
P
A
--
D
E
--
V
I
S
V
V
C
A
P
F
L
F
L
---
D
R
L
V
Q
A
--
A
D
G
---
T
D
L
K
I
--
G
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
--
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
G
P
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
P
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
35
PsiBlast_CBE
85.51
47%
-82
- C3 -
3GVG
2
TPIS_MYCTU
B:
[24-273]
-
S
R
K
P
L
I
A
G
N
W
K
M
N
L
N
H
Y
E
A
I
A
L
V
Q
K
I
-
A
F
-
S
L
P
D
K
YY
D
R
--
V
D
V
A
V
I
P
P
F
T
D
L
---
R
S
V
Q
T
L
--
V
D
G
---
D
K
L
R
L
TY
G
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
N
H
V
A
H
N
I
E
Q
L
R
G
S
L
A
G
L
L
A
E
Q
I
--
G
S
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
A
I
R
K
E
L
A
S
L
A
S
P
R
I
A
D
T
V
R
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
A
A
I
A
A
15
PsiBlast_PDB
85.21
47%
-81
- C3 -
3GVG
1
TPIS_MYCTU
A:
[24-273]
-
S
R
K
P
L
I
A
G
N
W
K
M
N
L
N
H
Y
E
A
I
A
L
V
Q
K
I
-
A
F
-
S
L
P
D
K
Y
Y
D
R
--
V
D
V
A
V
I
P
P
F
T
D
L
---
R
S
V
Q
T
L
--
V
D
G
---
D
K
L
R
L
T
Y
G
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
N
H
V
A
H
N
I
E
Q
L
R
G
S
L
A
G
L
L
A
E
Q
I
--
G
S
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
A
I
R
K
E
L
A
S
L
A
S
P
R
I
A
D
T
V
R
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
A
A
I
A
A
59
PsiBlast_CBE
84.35
41%
-86
* C3 *
4BI7
2
TPI1_GIAIN
A:
[3-252]
-
A
R
R
P
F
I
G
G
N
F
K
C
N
G
S
L
D
F
I
K
S
H
V
A
A
I
-
A
A
H
K
I
P
D
S
------
V
D
V
V
I
A
P
S
A
V
H
L
---
S
T
A
I
A
A
--
N
T
S
---
K
Q
L
R
I
--
A
A
Q
N
V
Y
L
E
G
N
G
A
W
T
G
E
T
S
V
E
M
L
Q
D
M
G
L
K
H
V
I
V
G
H
S
E
R
R
R
I
M
G
E
T
D
E
Q
S
A
K
K
A
K
R
A
L
E
K
G
M
T
V
I
F
C
V
G
E
T
L
D
E
R
K
A
N
R
T
M
E
V
N
I
A
Q
L
E
A
L
G
K
E
L
G
E
S
K
M
LW
K
E
V
V
I
A
Y
E
P
V
W
S
I
G
T
G
V
V
A
T
P
E
Q
A
E
E
V
H
V
G
L
R
K
W
F
A
E
K
V
A
A
E
G
A
Q
H
I
R
I
I
Y
G
G
S
A
N
G
S
N
C
E
K
L
G
Q
C
P
N
I
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
M
T
M
I
D
I
L
T
69
PsiBlast_CBE
84.10
40%
-81
- C3 -
4BI6
1
TPI1_GIAIN
A:
[3-252]
-
A
R
R
P
F
I
G
G
N
F
K
C
N
G
S
L
D
F
I
K
S
H
V
A
A
I
-
A
A
H
K
I
P
D
S
------
V
D
V
V
I
A
P
S
A
V
H
L
---
S
T
A
I
A
A
--
N
T
S
---
K
Q
L
R
I
--
A
A
Q
N
V
Y
L
E
G
N
G
A
W
T
G
E
T
S
V
E
M
L
Q
D
M
G
L
K
H
V
I
V
G
H
S
E
R
R
R
I
M
G
E
T
D
E
Q
S
A
K
K
A
K
R
A
L
E
K
G
M
T
V
I
F
C
V
G
E
T
L
D
E
R
K
A
N
R
T
M
E
V
N
I
A
Q
L
E
A
L
G
K
E
L
G
E
S
K
M
LW
K
E
V
V
I
A
Y
E
P
V
W
S
I
G
T
G
V
V
A
T
P
E
Q
A
E
E
V
H
V
G
L
R
K
W
F
V
E
K
V
A
A
E
G
A
Q
H
I
R
I
I
Y
G
G
S
A
N
G
S
N
N
E
K
L
G
Q
C
P
N
I
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
M
T
M
I
D
I
L
T
14
PsiBlast_PDB
83.87
47%
-80
- C3 -
3TAO
2
TPIS_MYCTU
A:
[2-251]
-
S
R
K
P
L
I
A
G
N
W
K
M
N
L
N
H
Y
E
A
I
A
L
V
Q
K
I
-
A
F
-
S
L
P
D
K
Y
Y
D
R
--
V
D
V
A
V
I
P
P
F
T
D
L
---
R
S
V
Q
T
L
--
V
D
G
---
D
K
L
R
L
T
Y
G
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
N
H
V
A
H
N
I
E
Q
L
R
G
S
L
A
G
L
L
A
E
Q
I
--
G
S
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
A
I
R
K
E
L
A
S
L
A
S
P
R
I
A
D
T
V
R
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
A
A
I
A
A
109
HHSearch
80.93
38%
-82
- C3 -
2VXN
7
TPIS_LEIME
A:
[3-250]
A
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
I
-
S
--
H
D
--
V
Q
C
V
V
A
P
T
F
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
---
P
K
Y
V
I
--
S
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
--
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
A
T
R
57
PsiBlast_CBE
80.67
42%
-78
- C3 -
2I9E
2
?
B:
[2-244]
-
A
R
K
F
V
V
G
G
N
W
K
M
N
G
D
K
K
Q
I
N
E
I
I
G
F
L
-
K
S
-
G
-
P
L
N
--
Q
D
--
T
E
V
V
V
G
V
P
A
I
Y
L
---
E
L
V
R
T
C
--
V
P
A
---
S
-
I
G
V
--
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
V
G
A
D
W
V
I
L
G
H
S
E
R
R
Q
I
F
G
E
S
D
E
L
I
A
E
K
V
C
H
A
L
E
S
G
L
K
V
I
A
C
I
G
E
T
L
E
E
R
E
A
G
K
T
E
E
V
V
F
R
Q
T
K
A
I
A
A
K
V
N
D
W
----
S
N
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
D
V
H
K
A
L
R
Q
W
I
C
E
N
I
D
A
K
V
G
N
S
I
R
I
Q
Y
G
G
S
V
T
A
A
N
C
K
E
L
A
S
Q
P
D
I
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
N
A
R
Q
55
PsiBlast_CBE
80.58
42%
-81
- C3 -
2I9E
3
?
D:
[2-244]
-
A
R
K
F
V
V
G
G
N
W
K
M
N
G
D
K
K
Q
I
N
E
I
I
G
F
L
-
K
S
-
G
-
P
L
N
--
Q
D
--
T
E
V
V
V
G
V
P
A
I
Y
L
---
E
L
V
R
T
C
--
V
P
A
---
S
-
I
G
V
--
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
V
G
A
D
W
V
I
L
G
H
S
E
R
R
Q
I
F
G
E
S
D
E
L
I
A
E
K
V
C
H
A
L
E
S
G
L
K
V
I
A
C
I
G
E
T
L
E
E
R
E
A
G
K
T
E
E
V
V
F
R
Q
T
K
A
I
A
A
K
V
N
D
W
----
S
N
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
D
V
H
K
A
L
R
Q
W
I
C
E
N
I
D
A
K
V
G
N
S
I
R
I
Q
Y
G
G
S
V
T
A
A
N
C
K
E
L
A
S
Q
P
D
I
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
N
A
R
Q
50
PsiBlast_CBE
80.32
42%
-86
- C3 -
4MVA
4
?
A:
[26-270]
--
R
H
P
L
V
M
G
N
W
K
L
N
G
S
R
H
M
V
H
E
L
V
S
N
L
-
R
K
-
E
L
A
G
V
--
A
G
--
C
A
V
A
I
A
P
P
E
M
Y
I
---
D
M
A
K
R
E
--
A
E
G
---
S
H
I
M
L
--
G
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
H
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
D
A
V
L
K
T
Q
G
A
A
A
F
--
E
G
A
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
S
A
T
P
A
Q
A
Q
A
V
H
K
F
I
R
D
H
I
-
A
K
V
D
A
N
I
A
E
Q
V
I
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
A
A
E
123
Fugue
79.47
37%
-78
- C3 -
1IF2
1
TPIS_LEIME
A:
[3-251]
A
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
T
T
A
S
I
E
K
L
V
Q
V
F
-
N
E
-
H
T
I
S
H
--
D
---
V
Q
C
V
V
A
P
T
F
V
H
I
---
P
L
V
Q
A
K
--
L
R
N
---
P
K
Y
V
I
--
S
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
--
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
G
T
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
A
T
R
49
PsiBlast_CBE
78.17
42%
-87
- C3 -
4MVA
3
?
B:
[26-270]
--
R
H
P
L
V
M
G
N
W
K
L
N
G
S
R
H
M
V
H
E
L
V
S
N
L
-
R
K
-
E
L
A
G
V
--
A
G
--
C
A
V
A
I
A
P
P
E
M
Y
I
---
D
M
A
K
R
E
--
A
E
G
---
S
H
I
M
L
--
G
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
H
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
D
A
V
L
K
T
Q
G
A
A
A
F
--
E
G
A
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
S
A
T
P
A
Q
A
Q
A
V
H
K
F
I
R
D
H
I
-
A
K
V
D
A
N
I
A
E
Q
V
I
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
A
A
E
103
HHSearch
78.08
37%
-84
- C3 -
2J27
1
TPIS_TRYBB
A:
[2-249]
S
K
P
Q
P
I
A
A
A
N
W
K
C
N
G
S
Q
Q
S
L
S
E
L
I
D
L
F
-
N
S
-
T
S
I
-
N
--
H
D
--
V
Q
C
V
V
A
S
T
F
V
H
L
---
A
M
T
K
E
R
--
L
S
H
---
P
K
F
V
I
--
A
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
--
A
K
V
V
I
A
Y
E
A
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
G
A
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
K
A
T
Q
70
PsiBlast_CBE
77.20
40%
-72
- C3 -
4FF7
13
TPIS_YEAST
B:
[2-239]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
P
----
E
N
--
V
E
V
V
I
C
P
P
A
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
---
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
S
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
----
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
65
PsiBlast_CBE
76.96
40%
-69
- C3 -
7TIM
1
TPIS_YEAST
B:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
P
----
E
N
--
V
E
V
V
I
C
P
P
A
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
---
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
----
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
71
PsiBlast_CBE
76.78
40%
-71
- C3 -
4FF7
9
TPIS_YEAST
A:
[2-239]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
P
----
E
N
--
V
E
V
V
I
C
P
P
A
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
---
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
S
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
----
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
68
PsiBlast_CBE
76.78
40%
-72
- C3 -
2YPI
1
TPIS_YEAST
A:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
P
----
E
N
--
V
E
V
V
I
C
P
P
A
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
---
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
----
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
75
PsiBlast_CBE
76.42
40%
-74
- C3 -
3YPI
1
TPIS_YEAST
A:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
P
----
E
N
--
V
E
V
V
I
C
P
P
A
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
---
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
Q
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
----
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
66
PsiBlast_CBE
76.15
40%
-70
- C3 -
7TIM
1
TPIS_YEAST
A:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
P
----
E
N
--
V
E
V
V
I
C
P
P
A
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
---
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
----
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
110
HHSearch
75.59
36%
-86
- C3 -
1O5X
2
TPIS_PLAFA
A:
[3-247]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
I
K
S
L
T
N
S
F
-
N
N
-
L
D
F
D
P
--
S
K
--
L
D
V
V
V
F
P
V
S
V
H
Y
---
D
H
T
R
K
L
--
L
-
Q
---
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
D
--
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
E
-
S
F
V
D
I
I
K
S
A
M
74
PsiBlast_CBE
75.35
40%
-74
- C3 -
3YPI
1
TPIS_YEAST
B:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
P
----
E
N
--
V
E
V
V
I
C
P
P
A
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
---
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
Q
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
----
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
100
PsiBlast_CBE
74.12
35%
-79
- C3 -
2VFH
1
TPIS_PLAFA
B:
[2-244]
-
A
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
LLQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
W
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
89
PsiBlast_CBE
73.64
35%
-78
- C3 -
2VFI
3
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
LLQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
67
PsiBlast_CBE
73.60
40%
-66
- C3 -
2YPI
1
TPIS_YEAST
B:
[1-238]
-
A
R
T
F
F
V
G
G
N
F
K
L
N
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
-
S
I
P
----
E
N
--
V
E
V
V
I
C
P
P
A
T
Y
L
---
D
Y
S
V
S
L
--
V
K
K
---
P
Q
V
T
V
--
G
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
----
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
G
D
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
F
V
D
I
I
N
S
R
N
-
82
PsiBlast_CBE
73.56
36%
-77
- C3 -
2VFE
3
TPIS_PLAFA
A:
[2-244]
-
A
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
L
LQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
S
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
92
PsiBlast_CBE
73.27
35%
-81
- C3 -
1O5X
2
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
L
L
Q
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
90
PsiBlast_CBE
73.19
35%
-76
- C3 -
2VFI
3
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
L
LQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
98
PsiBlast_CBE
72.68
35%
-83
- C3 -
1LZO
1
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
LLQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
93
PsiBlast_CBE
72.60
35%
-81
- C3 -
1M7P
1
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
LLQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
99
PsiBlast_CBE
72.18
35%
-76
- C3 -
1LYX
1
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
L
LQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
97
PsiBlast_CBE
72.02
35%
-79
- C3 -
1LZO
1
TPIS_PLAFA
D:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
LLQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
94
PsiBlast_CBE
72.02
35%
-80
- C3 -
1M7P
1
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
L
LQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
81
PsiBlast_CBE
71.82
36%
-79
- C3 -
2VFE
3
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
L
LQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
S
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
96
PsiBlast_CBE
71.70
35%
-80
- C3 -
1M7O
1
TPIS_PLAFA
A:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
L
LQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
95
PsiBlast_CBE
71.67
35%
-78
- C3 -
1M7O
1
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
LLQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
V
N
T
E
N
C
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M
91
PsiBlast_CBE
71.54
35%
-79
- C3 -
1O5X
1
TPIS_PLAFA
B:
[3-244]
--
R
K
Y
F
V
A
A
N
W
K
C
N
G
T
L
E
S
----
I
K
S
L
-
T
N
-
S
F
N
N
L
--
D
F
--
D
P
S
K
L
D
V
V
V
F
P
V
---
S
V
H
Y
D
H
--
T
R
K
LLQ
S
K
F
S
T
--
G
I
Q
N
V
S
K
F
G
N
G
S
Y
T
G
E
V
S
A
E
I
A
K
D
L
N
I
E
Y
V
I
I
G
H
F
E
R
R
K
Y
F
H
E
T
D
E
D
V
R
E
K
L
Q
A
S
L
K
N
N
L
K
A
V
V
C
F
G
E
S
L
E
Q
R
E
Q
N
K
T
I
E
V
I
T
K
Q
V
K
A
F
V
D
L
I
--
D
N
F
--
D
N
V
I
L
V
Y
E
P
L
W
A
I
G
T
G
K
T
A
T
P
E
Q
A
Q
L
V
H
K
E
I
R
K
I
V
K
D
T
C
G
E
K
Q
A
N
Q
I
R
I
L
Y
G
G
S
------
S
S
L
I
Q
Q
E
D
I
D
G
F
L
V
G
N
A
S
L
K
-
E
S
F
V
D
I
I
K
S
A
M