@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : gbs0787: (2015-12-03 )
MSKETLILLYGGRSAEREVSVLSAESVMRAINYDKFFVKTYFITQVGQFIKTQEFDEMPSSDEKLMTNQTVDLDKMVRPSDIYDDNAIVFPVLHGPMGEDGSIQGFLEVLRMPYVGTNILSSSVAMDKITTKQVLATVGVPQVAYQTYFEGDDLEHAIKLSLETLSFPIFVKPANMGSSVGISKATDESSLRSAIDLALKYDSRILIEQGVTAREIEVGILGNNDVKTTFPGEVVKDVDFYDYDAKYIDNKITMDIPAKVDEATMEAMRQYASKAFKAIGACGLSRCDFFLTKDGQIFLNELNTMPGFTQWSMYPLLWENMGLTYSDLIEKLVMLAKEMFEKRESHLI
Atome Classification :
(44 SA)
.........10........20.......---.30..-.-..-..--.40........50....-------.-..-------.--60..---.-------------..---.----------.---.-.70.-...-----....-80......----------.--.90........100.......110.......120.......130...-...-.140.......--150...--..-.-.----160...----.....170.......180.......190.......200.......210-.-......220.--...------...230...-----..------..240......--.250--.---------.......260.....-..270.......280.......290.......300.......310.......320.......330.......340......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSK
E
T
L
I
L
L
YGGRSAE
R
E
V
S
V
L
S
A
E
S
V
M
---
R
A
I
N
Y
-
D
-
K
F
-
F
V
--
K
T
Y
F
I
T
Q
V
G
Q
F
I
K
T
Q
E
F
-------D-EM-------P--S-SD---E-------------KL---M----------T---N-QTV
D
-
L
D
K-----MVRP-SDIYDDN
A
----------
I
--
V
F
P
V
LHGPMGEDG
S
I
Q
G
F
L
E
V
LRMPYV
G
T
N
I
L
SSSVAMD
K
I
T
T
K
Q
V
L
-
A
TV-GV
P
Q
V
A
Y
Q
T
YF--EGDD
L
E
--
H
A
-
I
-
K
----
L
S
-
L
ET----LS
F
P
I
F
V
KPANMGSSVGISKAT
D
E
S
S
L
R
S
A
I
D
L
A
L
KYD
S
R
I
L
I
EQGV
T
-
A
-
R
E
I
E
V
G
I
LGN--NDV------KTTFP
G
E
V
V
-----KD------VDFYDY
D
A
K
Y
I--D
N
-
K
--
I
---------
T
MDIPAKV
D
E
A
T
M
E
A
-
M
R
Q
Y
A
S
K
A
F
K
A
I
G
A
CGLSRC
D
F
F
LTKD
G
Q
I
F
L
N
ELNTMPGFTQWS
M
Y
P
L
L
W
E
NMGL
T
Y
S
D
L
I
E
K
L
V
M
L
A
K
E
M
F
E
K
R
ESHLI
1
PsiBlast_PDB
98.85
74%
-125
- C1 -
3K3P
-
DDL_STRMU
A:
[3-346]
--
K
E
T
L
V
L
L
Y
G
G
R
S
A
E
R
D
V
S
V
L
S
A
E
S
V
M
---
R
A
I
N
Y
-
D
-
N
F
-
L
V
--
K
T
Y
F
I
T
Q
A
G
D
F
I
K
T
Q
E
F
-------
D
-
S
Q
-------
P
--
S
------
D
-------------
K
L
---
M
----------
T
---
N
-
D
T
I
I
-
A
S
Q
-----
K
I
K
P
-
S
D
I
Y
E
E
E
A
----------
V
--
V
F
P
V
L
H
G
P
M
G
E
D
G
S
I
Q
G
F
L
E
V
L
K
M
P
Y
V
G
T
N
I
L
S
S
S
V
A
M
D
K
I
T
T
N
Q
V
L
E
S
A
T
-
T
I
P
Q
V
A
Y
V
A
L
I
--
E
G
E
P
L
E
--
S
K
-
L
-
A
----
E
V
-
E
E
K
----
L
I
Y
P
V
F
V
K
P
A
N
------
I
S
K
A
E
N
R
T
D
L
K
Q
A
I
A
L
A
L
K
Y
D
S
R
V
L
I
E
Q
G
V
D
-
A
-
R
E
I
E
V
G
I
L
G
N
--
T
D
V
------
K
T
T
L
P
G
E
I
V
------------------------------------------
T
M
A
I
P
A
E
I
D
P
V
I
V
E
K
-
M
R
D
Y
A
A
T
A
F
R
T
L
G
C
C
G
L
S
R
C
D
F
F
L
T
E
D
G
K
V
Y
L
N
E
L
N
T
M
P
G
F
T
--
S
M
Y
P
L
L
W
E
N
M
G
L
S
Y
S
V
L
I
E
E
L
V
S
L
A
K
E
M
F
D
K
R
E
S
---
56
HHSearch
96.37
75%
-121
- C1 -
3K3P
-
DDL_STRMU
A:
[3-346]
--
K
E
T
L
V
L
L
Y
G
G
R
S
A
E
R
D
V
S
V
L
S
A
E
S
V
M
---
R
A
I
N
Y
-
D
-
N
F
-
L
V
--
K
T
Y
F
I
T
Q
A
G
D
F
I
K
T
Q
E
F
-------
D
-
S
Q
-------
P
--
S
------
D
-------------
K
L
---
M
----------
T
---
N
-
D
T
I
I
A
S
Q
K
-----
I
K
P
--
S
D
I
Y
E
E
E
A
----------
V
--
V
F
P
V
L
H
G
P
M
G
E
D
G
S
I
Q
G
F
L
E
V
L
K
M
P
Y
V
G
T
N
I
L
S
S
S
V
A
M
D
K
I
T
T
N
Q
V
L
-
E
S
A
T
T
I
P
Q
V
A
Y
V
A
L
I
--
E
G
E
P
-
L
--
E
S
K
L
-
A
----
E
V
-
E
E
K
----
L
I
Y
P
V
F
V
K
P
A
N
------
I
S
K
A
E
N
R
T
D
L
K
Q
A
I
A
L
A
L
K
Y
D
S
R
V
L
I
E
Q
G
V
D
-
A
-
R
E
I
E
V
G
I
L
G
N
--
T
D
V
------
K
T
T
L
P
G
E
I
V
------------------------------------------
T
M
A
I
P
A
E
I
D
P
V
I
V
E
K
-
M
R
D
Y
A
A
T
A
F
R
T
L
G
C
C
G
L
S
R
C
D
F
F
L
T
E
D
G
K
V
Y
L
N
E
L
N
T
M
P
G
F
T
--
S
M
Y
P
L
L
W
E
N
M
G
L
S
Y
S
V
L
I
E
E
L
V
S
L
A
K
E
M
F
D
K
R
E
S
---
4
PsiBlast_PDB
83.73
47%
-105
- C1 -
2I8C
2
DDL_STAAC
A:
[3-351]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
K
-
D
-
K
Y
-
H
V
--
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-------
T
A
E
I
-------
K
--
S
-
T
D
---
E
-------------
L
H
---
L
----------
E
---
N
G
E
A
L
E
-
I
S
Q
-----
L
L
K
E
-
S
S
S
G
Q
P
Y
D
----------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
--
H
N
-
I
L
K
----
L
V
-
N
D
K
----
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
--
D
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
------
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
-
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
22
PsiBlast_CBE
83.28
47%
-101
- C1 -
2I8C
3
DDL_STAAC
B:
[3-351]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
K
-
D
-
K
Y
-
H
V
--
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-------
T
A
E
I
-------
K
--
S
-
T
D
---
E
-------------
L
H
---
L
----------
E
---
N
G
E
A
L
E
-
I
S
Q
-----
L
L
K
E
-
S
S
S
G
Q
P
Y
D
----------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
RS
E
Y
E
K
Y
E
--
H
N
-
I
L
K
----
L
V
-
N
D
K
----
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
--
D
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
------
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
-
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
21
PsiBlast_CBE
83.26
47%
-101
- C1 -
2I80
1
DDL_STAAC
B:
[3-351]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
K
-
D
-
K
Y
-
H
V
--
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-------
T
A
E
I
-------
K
--
S
-
T
D
---
E
-------------
L
H
---
L
----------
E
---
N
G
E
A
L
E
-
I
S
Q
-----
L
L
K
E
-
S
S
S
G
Q
P
Y
D
----------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
RS
E
Y
E
K
Y
E
--
H
N
-
I
L
K
----
L
V
-
N
D
K
----
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
--
D
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
------
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
-
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
23
PsiBlast_CBE
83.18
47%
-105
- C1 -
2I87
1
DDL_STAAC
B:
[3-351]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
K
-
D
-
K
Y
-
H
V
--
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-------
T
A
E
I
-------
K
--
S
-
T
D
---
E
-------------
L
H
---
L
----------
E
---
N
G
E
-
L
E
-
I
S
Q
-----
L
L
K
E
-
S
S
S
G
Q
P
Y
D
----------
A
--
V
F
P
L
L
H
G
P
--
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
--
H
N
-
I
L
K
----
L
V
-
N
D
K
----
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
--
D
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
------
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
-
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
3
PsiBlast_PDB
83.09
47%
-101
- C1 -
2I87
1
DDL_STAAC
A:
[3-351]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
K
-
D
-
K
Y
-
H
V
--
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-------
T
A
E
I
-------
K
--
S
-
T
D
---
E
-------------
L
H
---
L
----------
E
---
N
G
E
A
L
E
-
I
S
Q
-----
L
L
K
E
-
S
S
S
G
Q
P
Y
D
----------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
--
H
N
-
I
L
K
----
L
V
-
N
D
K
----
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
--
D
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
------
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
-
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
2
PsiBlast_PDB
81.52
47%
-102
- C1 -
2I80
1
DDL_STAAC
A:
[3-351]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
K
-
D
-
K
Y
-
H
V
--
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-------
T
A
E
I
-------
K
--
S
-
T
D
---
E
-------------
L
H
---
L
----------
E
---
N
G
E
A
L
E
-
I
S
Q
-----
L
L
K
E
-
S
S
S
G
Q
P
Y
D
----------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
R
S
E
Y
E
K
Y
E
--
H
N
-
I
L
K
----
L
V
-
N
D
K
----
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
--
D
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
------
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
-
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
57
HHSearch
80.65
47%
-96
- C1 -
2I87
1
DDL_STAAC
A:
[3-351]
--
K
E
N
I
C
I
V
F
G
G
K
S
A
E
H
E
V
S
I
L
T
A
Q
N
V
L
---
N
A
I
D
K
-
D
-
K
Y
-
H
V
--
D
I
I
Y
I
T
N
D
G
D
W
R
K
Q
N
N
I
-------
T
-
A
E
-------
I
--
K
-
S
T
DEL
H
-------------
L
E
---
N
GE--------
A
---
L
-
E
I
S
---
Q
L
-----
L
K
E
--
S
S
S
G
Q
P
Y
D
----------
A
--
V
F
P
L
L
H
G
P
N
G
E
D
G
T
I
Q
G
L
F
E
V
L
D
V
P
Y
V
G
N
G
V
L
S
A
A
S
S
M
D
K
L
V
M
K
Q
L
F
-
E
H
R
-
G
L
P
Q
L
P
Y
I
S
F
L
--
R
S
E
Y
E
K
Y
E
H
N
-
I
L
K
----
L
V
-
N
D
K
----
L
N
Y
P
V
F
V
K
P
A
N
L
G
S
S
V
G
I
S
K
C
N
N
E
A
E
L
K
E
G
I
K
E
A
F
Q
F
D
R
K
L
V
I
E
Q
G
V
N
-
A
-
R
E
I
E
V
A
V
L
G
N
--
D
Y
P
------
E
A
T
W
P
G
E
V
V
-----
K
D
------
V
A
F
----------------
V
---------
Q
L
Q
I
P
A
D
L
D
E
D
V
Q
L
T
-
L
R
N
M
A
L
E
A
F
K
A
T
D
C
S
G
L
V
R
A
D
F
F
V
T
E
D
N
Q
I
Y
I
N
E
T
N
A
M
P
G
F
T
A
F
S
M
Y
P
K
L
W
E
N
M
G
L
S
Y
P
E
L
I
T
K
L
I
E
L
A
K
E
R
H
Q
D
K
Q
K
N
K
Y
24
PsiBlast_CBE
77.97
37%
-99
- C1 -
3I12
1
DDLA_SALTY
D:
[3-352]
--
K
L
R
V
G
I
V
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
K
N
I
V
---
D
A
I
D
K
-
T
-
R
F
-
D
V
--
V
L
L
G
I
D
K
A
G
Q
W
H
V
N
D
A
E
-------
N
-
Y
L
-------
Q
--
N
-
A
D
---
D
-------------
P
A
HI
A
L
----------
R
---
P
-
S
A
I
S
-
L
A
Q
-----
V
P
G
K
-
H
Q
H
Q
L
I
N
A
QNGQPLPTVD
V
--
I
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
M
L
R
V
A
N
L
P
F
V
G
S
D
V
L
S
S
A
A
C
M
D
K
D
V
A
K
R
L
L
-
R
D
A
-
G
L
N
I
A
P
F
I
T
L
T
--
R
T
N
--
R
--
H
A
-
F
-
S
----
F
A
E
V
E
S
R
---
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
K
V
A
N
E
A
Q
Y
Q
Q
A
V
A
L
A
F
E
F
D
H
K
V
V
V
E
Q
G
I
K
-
G
-
R
E
I
E
C
A
V
L
G
N
--
D
N
P
------
Q
A
S
T
C
G
E
I
V
-----
L
N
------
S
E
F
Y
------
I
D-
D
N
-
G
--
A
---------
Q
V
V
V
P
A
Q
I
P
S
E
V
N
D
K
-
I
R
A
I
A
I
Q
A
Y
Q
T
L
G
C
A
G
M
A
R
V
D
V
F
L
T
A
D
N
E
V
V
I
N
E
I
N
T
L
P
G
F
T
N
I
S
M
Y
P
K
L
W
Q
A
S
G
L
G
Y
T
D
L
I
S
R
L
I
E
L
A
L
E
R
H
T
A
N
N
A
L
K
T
11
PsiBlast_PDB
77.94
39%
-86
- C1 -
2ZDQ
3
DDL_THET8
A:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
13
PsiBlast_PDB
77.79
37%
-101
- C1 -
3E5N
-
?
A:
[2-352]
-
R
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
---
D
A
L
D
P
-
Q
-
R
F
-
E
P
--
V
L
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
-------
S
-
F
L
-------
L
--
H
-
A
D
---
D
PA
R
I
A
L
HRSGR
G
V
A
L
---
L
----------
P
---
G
-
A
Q
Q
Q
-
Q
L
R
-----
P
I
Q
---
Q
A
L
A
Q
I
D
----------
V
--
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
-
R
D
A
-
R
L
A
-
V
A
P
F
V
C
F
--
D
R
H
T
A
A
--
H
A
D
V
-
D
----
T
L
-
I
A
Q
----
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
A
-
G
-
R
E
I
E
C
A
V
L
G
N
--
A
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
------------------------------------
E
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
-
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
--
16
PsiBlast_PDB
77.58
37%
-97
- C1 -
3R5F
2
?
A:
[20-369]
--
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
---
D
A
L
D
P
-
Q
-
R
F
-
E
P
--
V
L
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
-------
S
-
F
L
-------
L
--
H
-
A
D
---
D
PA
R
I
A
L
HRSGR
G
V
A
L
---
L
----------
P
---
G
-
A
Q
Q
Q
-
Q
L
R
-----
P
I
Q
----
A
L
A
Q
I
D
----------
V
--
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
-
R
D
A
-
R
L
A
-
V
A
P
F
V
C
F
--
D
R
H
T
A
A
--
H
A
D
V
-
D
----
T
L
-
I
A
Q
----
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
A
-
G
-
R
E
I
E
C
A
V
L
G
N
--
A
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
------------------------------------
E
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
-
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
R
S
5
PsiBlast_PDB
77.49
37%
-98
- C1 -
3I12
1
DDLA_SALTY
A:
[2-352]
-
A
K
L
R
V
G
I
V
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
K
N
I
V
---
D
A
I
D
K
-
T
-
R
F
-
D
V
--
V
L
L
G
I
D
K
A
G
Q
W
H
V
N
D
A
E
-------
N
-
Y
L
-------
Q
--
N
-
A
D
---
D
-------------
P
A
H
I
A
L
----------
R
---
P
-
S
A
I
S
-
L
A
Q
-----
V
P
G
K
-
H
Q
H
Q
L
I
N
A
QNGQPLPTVD
V
--
I
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
M
L
R
V
A
N
L
P
F
V
G
S
D
V
L
S
S
A
A
C
M
D
K
D
V
A
K
R
L
L
-
R
D
A
-
G
L
N
I
A
P
F
I
T
L
T
--
R
T
N
--
R
--
H
A
-
F
-
S
----
F
A
E
V
E
S
R
---
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
K
V
A
N
E
A
Q
Y
Q
Q
A
V
A
L
A
F
E
F
D
H
K
V
V
V
E
Q
G
I
K
-
G
-
R
E
I
E
C
A
V
L
G
N
--
D
N
P
------
Q
A
S
T
C
G
E
I
V
-----
L
N
------
S
E
F
Y
--
D
T
K
Y
I
D-
D
N
-
G
--
A
---------
Q
V
V
V
P
A
Q
I
P
S
E
V
N
D
K
-
I
R
A
I
A
I
Q
A
Y
Q
T
L
G
C
A
G
M
A
R
V
D
V
F
L
T
A
D
N
E
V
V
I
N
E
I
N
T
L
P
G
F
T
N
I
S
M
Y
P
K
L
W
Q
A
S
G
L
G
Y
T
D
L
I
S
R
L
I
E
L
A
L
E
R
H
T
A
N
N
A
L
K
T
17
PsiBlast_PDB
77.36
37%
-98
- C1 -
4L1K
2
?
A:
[19-369]
-
R
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
---
D
A
L
D
P
-
Q
-
R
F
-
E
P
--
V
L
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
-------
S
-
F
L
-------
L
--
H
-
A
D
---
D
PA
R
I
A
L
HRSGR
G
V
A
L
---
L
----------
P
---
G
-
A
Q
Q
Q
-
Q
L
R
-----
P
I
Q
---
Q
A
L
A
Q
I
D
----------
V
--
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
-
R
D
A
-
R
L
A
-
V
A
P
F
V
C
F
--
D
R
H
T
A
A
--
H
A
D
V
-
D
----
T
L
-
I
A
Q
----
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
A
-
G
-
R
E
I
E
C
A
V
L
G
N
--
A
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
------------------------------------
E
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
-
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
--
27
PsiBlast_CBE
77.21
39%
-83
- C1 -
2ZDQ
3
DDL_THET8
B:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
15
PsiBlast_PDB
77.14
37%
-100
- C1 -
3RFC
2
?
A:
[19-369]
-
R
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
---
D
A
L
D
P
-
Q
-
R
F
-
E
P
--
V
L
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
-------
S
-
F
L
-------
L
--
H
-
A
D
---
D
PA
R
I
A
L
HRSGR
G
V
A
L
---
L
----------
P
---
G
-
A
Q
Q
Q
-
Q
L
R
-----
P
I
Q
---
Q
A
L
A
Q
I
D
----------
V
--
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
-
R
D
A
-
R
L
A
-
V
A
P
F
V
C
F
--
D
R
H
T
A
A
--
H
A
D
V
-
D
----
T
L
-
I
A
Q
----
L
G
L
P
L
F
V
K
P
A
N
Q
G
S
S
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
A
-
G
-
R
E
I
E
C
A
V
L
G
N
--
A
V
P
------
H
A
S
V
C
G
E
V
V
-----
V
------------------------------------
E
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
-
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
R
S
14
PsiBlast_PDB
77.08
37%
-101
- C1 -
4ME6
2
?
A:
[21-371]
-
R
K
I
R
V
G
L
I
F
G
G
K
S
A
E
H
E
V
S
L
Q
S
A
R
N
I
L
---
D
A
L
D
P
-
Q
-
R
F
-
E
P
--
V
L
I
G
I
D
K
Q
G
Q
W
H
V
N
D
P
D
-------
S
-
F
L
-------
L
--
H
-
A
D
---
D
PA
R
I
A
L
HRSGR
G
V
A
L
---
L
----------
P
---
G
-
A
Q
Q
Q
-
Q
L
R
-----
P
I
Q
------
A
Q
I
D
----------
V
--
V
F
P
I
V
H
G
T
L
G
E
D
G
S
L
Q
G
L
L
R
M
A
N
L
P
F
V
G
S
G
V
L
G
S
A
V
A
M
D
K
D
M
A
K
R
V
L
-
R
D
A
-
R
L
A
-
V
A
P
F
V
C
F
--
D
R
H
T
-
A
--
H
A
D
V
-
D
----
T
L
-
I
A
Q
----
L
G
L
P
L
F
V
K
P
A
N
Q
---
V
G
V
S
Q
V
R
T
A
D
A
F
A
A
A
L
A
L
A
L
A
Y
D
H
K
V
L
V
E
A
A
V
A
-
G
-
R
E
I
E
C
A
V
L
G
N
--
A
V
P
------
H
A
S
V
C
G
E
V
V
------------------------------------------
E
I
V
I
P
A
D
I
D
A
Q
T
Q
Q
R
-
I
Q
Q
I
A
V
Q
A
Y
Q
A
L
G
C
A
G
M
A
R
V
D
V
F
L
C
A
D
G
R
I
V
I
N
E
V
N
T
L
P
G
F
T
R
I
S
V
Y
P
K
L
W
Q
A
S
G
L
D
Y
R
G
L
I
T
R
L
I
E
L
A
L
E
R
H
T
D
D
Q
L
L
R
S
59
HHSearch
77.02
36%
-99
- C1 -
3LWB
1
DDL_MYCTU
A:
[8-368]
D
R
R
V
R
V
A
V
V
F
G
G
-----
A
I
S
C
V
S
A
G
S
I
L
---
R
N
L
D
S
-
R
-
R
F
-
D
V
--
I
A
V
G
I
T
P
A
G
S
W
V
L
T
D
A
N
----------------------------------------------------------------------
V
S
-----
L
P
P
G
A
G
E
V
L
E
S
V
D
----------
V
--
V
F
P
V
L
H
G
P
Y
G
E
D
G
T
I
Q
G
L
L
E
L
A
G
V
P
Y
V
G
A
G
V
L
A
S
A
V
G
M
D
K
E
F
T
K
K
L
L
-
A
A
D
-
G
L
P
V
G
A
Y
A
V
L
R
--
P
P
R
S
-
T
--
L
--
H
-
R
----
Q
E
-
C
E
R
----
L
G
L
P
V
F
V
K
P
A
R
G
G
S
S
I
G
V
S
R
V
S
S
W
D
Q
L
P
A
A
V
A
R
A
R
R
H
D
P
K
V
I
V
E
A
A
I
S
-
G
-
R
E
L
E
C
G
V
L
E
M
PD
G
T
L
------
E
A
S
T
L
G
E
I
R
-----
V
A
GVRGRE
D
S
F
Y
D
F
A
T
K
Y
L
--
D
D
-
A
--
A
---------
E
L
D
V
P
A
K
V
D
D
Q
V
A
E
A
-
I
R
Q
L
A
I
R
A
F
A
A
I
D
C
R
G
L
A
R
V
D
F
F
L
T
D
-
D
G
P
V
I
N
E
I
N
T
M
P
G
F
T
T
I
S
M
Y
P
R
M
W
A
A
S
G
V
D
Y
P
T
L
L
A
T
M
I
E
T
T
L
A
R
---------
9
PsiBlast_PDB
77.01
39%
-91
- C1 -
2ZDG
1
DDL_THET8
A:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
------------------------------------------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
10
PsiBlast_PDB
76.18
39%
-81
- C1 -
2ZDH
4
DDL_THET8
A:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
36
PsiBlast_CBE
76.09
39%
-90
- C1 -
2YZM
1
DDL_THET8
C:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
--------------
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
28
PsiBlast_CBE
75.78
39%
-81
- C1 -
2ZDH
3
DDL_THET8
D:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
29
PsiBlast_CBE
75.70
39%
-84
- C1 -
2ZDH
4
DDL_THET8
C:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
F
Y
---
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
34
PsiBlast_CBE
75.39
39%
-89
- C1 -
2YZN
1
DDL_THET8
C:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
------------
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
31
PsiBlast_CBE
75.38
39%
-90
- C1 -
2ZDG
2
DDL_THET8
D:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
-----------------
A
---------
E
L
L
I
P
A
P
L
---
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
32
PsiBlast_CBE
75.26
39%
-82
- C1 -
2ZDG
2
DDL_THET8
C:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
33
PsiBlast_CBE
75.16
39%
-90
- C1 -
2ZDG
1
DDL_THET8
B:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
----------------------------
E
L
L
I
P
A
P
L
D
--
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
30
PsiBlast_CBE
75.16
39%
-82
- C1 -
2ZDH
4
DDL_THET8
B:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
F
Y
---------
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
62
HHSearch
74.83
31%
-89
- C1 -
1EHI
4
DDL_LEUMM
A:
[3-360]
--
K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
---
N
A
I
E
A
-
T
-
G
K
Y
E
I
--
I
V
F
A
I
A
Q
N
G
F
F
L
D
T
E
S
S
-------
K
-
K
I
-------
L
--
A
-
L
E
---
D
-------------
E
Q
---
P
I
V
D
A
F
M
K
T
VD
A
---
S
-
D
P
L
A
---
R
-----
I
H
A
--
L
K
S
A
G
D
F
D
----------
I
--
F
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
-
T
V
N
-
G
I
R
N
T
K
Y
I
V
V
D
--
P
E
S
A
N
N
--
W
S
-
W
-
D
----
K
I
-
V
A
E
----
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
-
G
A
R
E
L
E
V
G
V
I
G
N
--
D
Q
P
------
L
V
S
E
I
G
A
H
T
-----
V
P
NQGSG-
D
G
W
Y
D
Y
N
N
K
F
V
--
D
N
-
S
--
A
V
--------
H
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
-
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
-
39
PsiBlast_CBE
74.71
32%
-94
- C1 -
1EHI
4
DDL_LEUMM
A:
[3-359]
--
K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
---
N
A
I
E
A
T
G
-
K
Y
-
E
I
--
I
V
F
A
I
A
Q
N
G
F
F
L
D
T
E
S
S
K
K
I
L
A
LE
D
-
E
Q
-------
P
--
I
-
V
D
---
A
-------------
F
M
---
K
----------
T
---
V
-
D
A
S
D
-
P
L
A
-----
R
I
H
A
-
L
K
S
A
G
D
F
D
----------
I
--
F
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
-
T
V
N
-
G
I
R
N
T
K
Y
I
V
V
------
D
P
E
--
S
A
-
N
-
N
----
W
S
-
W
D
K
I
V
A
E
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
A
-
R
E
L
E
V
G
V
I
G
N
--
D
Q
P
L
V
S
E
I
G
A
H
T
V
P
N
Q
G
S
-----
G
D
-------
G
W
Y
D
Y
N
N
K
F
V
--
D
N
-
S
A-
V
---------
H
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
-
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
-
76
Fugue
74.69
32%
-90
- C1 -
1EHI
4
DDL_LEUMM
A:
[3-362]
--
K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
---
N
A
I
E
A
-
T
G
K
Y
-
E
I
--
I
V
F
A
I
A
Q
N
G
F
F
L
D
T
E
S
S
-------
K
-
K
I
L
A
LEDE
Q
P
--
I
-
V
D
---
A
-------------
F
M
---
K
----------
T
---
V
-
D
A
S
D
-
P
L
A
-----
R
I
H
A
-
L
K
S
A
G
D
F
D
----------
I
--
F
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
-
T
V
N
-
G
I
R
N
T
K
Y
I
V
V
D
--
P
E
S
A
N
N
W
S---
W
-
D
----
K
I
-
V
A
E
----
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
A
-
R
E
L
E
V
G
V
I
G
N
--
D
Q
P
------
L
V
S
E
I
G
A
H
T
V
P
NQG
S
G
------
D
G
W
Y
D
Y
N
N
K
F
V
--
D
N
S
A
--
V
---------
H
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
-
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
-
77
Fugue
74.56
32%
-91
- C1 -
1EHI
4
DDL_LEUMM
A:
[3-362]
--
K
K
R
V
A
L
I
F
G
G
N
S
S
E
H
D
V
S
K
R
S
A
Q
N
F
Y
---
N
A
I
E
A
T
G
-
K
Y
-
E
I
--
I
V
F
A
I
A
Q
N
G
F
F
L
D
T
E
S
S
-------
K
-
K
I
L
A
LEDE
Q
P
--
I
-
V
D
---
A
-------------
F
M
---
K
----------
T
---
V
-
D
A
S
D
-
P
L
A
-----
R
I
H
A
-
L
K
S
A
G
D
F
D
----------
I
--
F
F
P
V
V
H
G
N
L
G
E
D
G
T
L
Q
G
L
F
K
L
L
D
K
P
Y
V
G
A
P
L
R
G
H
A
V
S
F
D
K
A
L
T
K
E
L
L
-
T
V
N
-
G
I
R
N
T
K
Y
I
V
V
D
--
P
E
S
A
N
N
--
W
S
-
W
-
D
----
K
I
-
V
A
E
----
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
A
-
R
E
L
E
V
G
V
I
G
N
--
D
Q
P
------
L
V
S
E
I
G
A
H
T
V
P
NQG
S
G
------
D
G
W
Y
D
Y
N
N
K
F
V
--
D
N
S
A
--
V
---------
H
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
-
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
-
8
PsiBlast_PDB
74.17
39%
-88
- C1 -
2YZN
1
DDL_THET8
A:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
--
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
35
PsiBlast_CBE
73.78
39%
-85
- C1 -
2YZN
1
DDL_THET8
B:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
F
Y
------
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
7
PsiBlast_PDB
73.73
39%
-87
- C1 -
2YZM
1
DDL_THET8
A:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
F
Y
D
Y
E
T
K
Y
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
37
PsiBlast_CBE
73.59
39%
-89
- C1 -
2YZM
1
DDL_THET8
B:
[3-317]
-----
V
L
L
I
A
G
G
V
S
P
E
H
E
V
S
L
L
S
A
E
G
V
L
---
R
H
I
-----
P
F
-
P
T
--
D
L
A
V
I
A
Q
D
G
R
W
L
L
G
E
K
------------------------
A
L
---
T
-------------
A
L
---
E
----------
A
---
K
-
A
A
P
E
-
G
E
H
-----
P
F
P
P
-
P
L
S
W
E
R
Y
D
----------
V
--
V
F
P
L
L
H
G
R
F
G
E
D
G
T
V
Q
G
F
L
E
L
L
G
K
P
Y
V
G
A
G
V
A
A
S
A
L
C
M
D
K
D
L
S
K
R
V
L
-
A
Q
A
-
G
V
P
V
V
P
W
V
A
V
R
--
K
G
E
P
P
V
--
V
P
-
F
-
D
----
P
P
-
F
F
V
-----------
K
P
A
N
T
G
S
S
V
G
I
S
R
V
E
R
F
Q
D
L
E
A
A
L
A
L
A
F
R
Y
D
E
K
A
V
V
E
K
A
L
S
-
P
V
R
E
L
E
V
G
V
L
G
N
--
V
F
G
------
E
A
S
P
V
G
E
V
R
-----
Y
E
------
A
P
F
-------
T
--
P
G
-
R
--
A
---------
E
L
L
I
P
A
P
L
D
P
G
T
Q
E
T
-
V
Q
E
L
A
L
K
A
Y
K
V
L
G
V
R
G
M
A
R
V
D
F
F
L
A
-
E
G
E
L
Y
L
N
E
L
N
T
I
P
G
F
T
P
T
S
M
Y
P
R
L
F
E
A
G
G
V
A
Y
P
E
L
L
R
R
L
V
E
L
A
L
T
----------
63
HHSearch
70.49
32%
-82
- C1 -
1E4E
13
VANA_ENTFC
A:
[2-342]
-
N
R
I
K
V
A
I
L
F
G
G
C
S
E
E
H
D
V
S
V
K
S
A
I
E
I
A
---
A
N
I
N
K
-
E
-
K
Y
-
E
P
--
L
Y
I
G
I
T
K
S
G
V
W
K
M
C
E
K
P
-------
C
-
A
E
-------
W
EN
E
N
C
Y
---
S
AV-----------
L
S
---
P
----------
D
KKM
H
-
G
L
L
V
---
K
-----
K
N
H
--
E
Y
E
I
N
H
V
D
----------
V
--
A
F
S
A
L
H
G
K
S
G
E
D
G
S
I
Q
G
L
F
E
L
S
G
I
P
F
V
G
C
D
I
Q
S
S
A
I
C
M
D
K
S
L
T
Y
I
V
A
-
K
N
A
-
G
I
A
T
P
A
F
W
V
I
N
--
K
D
D
R
--------------
P
V
-
A
A
T
----
F
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
K
K
V
N
S
A
D
E
L
D
Y
A
I
E
S
A
R
Q
Y
D
S
K
I
L
I
E
Q
A
V
S
-
G
-
C
E
V
G
C
A
V
L
G
N
S-
A
A
L
------
V
V
G
E
V
D
Q
I
R
-----
L
Q
------
Y
G
I
F
R
I
H
Q
E
V
E
PE
K
G
-
S
EN
A
---------
V
I
T
V
P
A
D
L
S
A
E
E
R
G
R
-
I
Q
E
T
V
K
K
I
Y
K
T
L
G
C
R
G
L
A
R
V
D
M
F
L
Q
D
N
G
R
I
V
L
N
E
V
N
T
L
P
G
F
T
S
Y
S
R
Y
P
R
M
M
A
A
A
G
I
S
L
P
E
L
I
D
R
L
I
V
L
A
L
K
----------
46
PsiBlast_CBE
69.34
33%
-87
- C1 -
1E4E
13
VANA_ENTFC
A:
[2-340]
-
N
R
I
K
V
A
I
L
F
G
G
C
S
E
E
H
D
V
S
V
K
S
A
I
E
I
A
---
A
N
I
N
K
-
E
-
K
Y
-
E
P
--
L
Y
I
G
I
T
K
S
G
V
W
----
K
M
-------
C
-
E
K
-------
P
--
C
-
A
E
WE-
N
-------------
E
N
---
C
----------
Y
---
S
-
A
V
L
S
-
P
D
K
KMH
G
L
L
V
K
K
-
N
H
E
Y
E
I
N
H
----------
V
D
V
A
F
S
A
L
H
G
K
S
G
E
D
G
S
I
Q
G
L
F
E
L
S
G
I
P
F
V
G
C
D
I
Q
S
S
A
I
C
M
D
K
S
L
T
Y
I
V
A
-
K
N
A
-
G
I
A
T
P
A
F
W
V
I
N
--
K
D
D
R
P
V
--
A
A
-------------
T
----
F
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
K
K
V
N
S
A
D
E
L
D
Y
A
I
E
S
A
R
Q
Y
D
S
K
I
L
I
E
Q
A
V
S
-
G
-
C
E
V
G
C
A
V
L
G
N
--
S
A
A
------
L
V
V
--
G
E
V
-------
D
------
Q
I
R
L
Q
Y
G
I
F
R
I
--
H
Q
-
E
--
V
EPEKGSEN
A
V
I
T
V
P
A
D
L
S
A
E
E
R
G
R
-
I
Q
E
T
V
K
K
I
Y
K
T
L
G
C
R
G
L
A
R
V
D
M
F
L
Q
D
N
G
R
I
V
L
N
E
V
N
T
L
P
G
F
T
S
Y
S
R
Y
P
R
M
M
A
A
A
G
I
S
L
P
E
L
I
D
R
L
I
V
L
A
L
K
----------
52
PsiBlast_CBE
68.79
31%
-100
- C1 -
1IOW
4
DDLB_ECOLI
A:
[3-305]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
G
I
-
D
-
A
Y
-
P
V
D
P
K
E
V
D
V
T
Q
----
L
K
S
M
G
F
-------
Q
-
K
---------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
-
Q
G
A
-
G
L
P
-
V
A
P
W
V
A
L
--
T
R
A
E
F
E
--
K
G
-
L
-
S
D
K
Q
L
A
E
-
I
S
A
----
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
--
E
I
L
------
P
S
I
---
R
I
Q
-----
P
S
------
G
T
F
Y
D
Y
E
A
K
F
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
-
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
D
-----------
49
PsiBlast_CBE
68.78
33%
-88
- C1 -
1E4E
12
VANA_ENTFC
B:
[2-340]
-
N
R
I
K
V
A
I
L
F
G
G
C
S
E
E
H
D
V
S
V
K
S
A
I
E
I
A
---
A
N
I
N
K
-
E
-
K
Y
-
E
P
--
L
Y
I
G
I
T
K
S
G
V
W
----
K
M
-------
C
-
E
K
-------
P
--
C
-
A
E
WE-
N
-------------
E
N
---
C
----------
Y
---
S
-
A
V
L
S
-
P
D
K
KMHGL
L
V
K
K
-
N
H
E
Y
E
I
N
H
----------
V
DV
A
F
S
A
L
H
G
K
S
G
E
D
G
S
I
Q
G
L
F
E
L
S
G
I
P
F
V
G
C
D
I
Q
S
S
A
I
C
M
D
K
S
L
T
Y
I
V
A
-
K
N
A
-
G
I
A
T
P
A
F
W
V
I
N
--
K
D
D
R
P
V
--
A
A
-------------
T
----
F
T
Y
P
V
F
V
K
P
A
R
S
G
S
S
F
G
V
K
K
V
N
S
A
D
E
L
D
Y
A
I
E
S
A
R
Q
Y
D
S
K
I
L
I
E
Q
A
V
S
-
G
-
C
E
V
G
C
A
V
L
G
N
--
S
A
A
------
L
V
V
--
G
E
V
-------
D
------
Q
I
R
L
Q
Y
G
I
F
R
I
--
H
Q
-
E
--
V
EPEKGSENA
V
I
T
V
P
A
D
L
S
A
E
E
R
G
R
-
I
Q
E
T
V
K
K
I
Y
K
T
L
G
C
R
G
L
A
R
V
D
M
F
L
Q
D
R
G
R
I
V
L
N
E
V
N
T
L
P
G
F
T
S
Y
S
R
Y
P
R
M
M
A
A
A
G
I
S
L
P
E
L
I
D
R
L
I
V
L
A
L
-----------
51
PsiBlast_CBE
67.66
31%
-97
- C1 -
1IOV
5
DDLB_ECOLI
A:
[3-305]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
G
I
-
D
-
A
Y
-
P
V
DP
K
E
V
D
V
T
Q
----
L
K
S
M
G
F
-------
Q
-
K
---------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
-
Q
G
A
-
G
L
P
-
V
A
P
W
V
A
L
--
T
R
A
E
F
E
--
K
G
-
L
-
S
D
K
Q
L
A
E
-
I
S
A
----
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
--
E
I
L
------
P
S
I
---
R
I
Q
-----
P
S
------
G
T
F
Y
D
Y
E
A
K
Y
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
-
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
D
-----------
50
PsiBlast_CBE
66.58
31%
-98
- C1 -
2DLN
4
DDLB_ECOLI
A:
[3-305]
---
D
K
I
A
V
L
L
G
G
T
S
A
E
R
E
V
S
L
N
S
G
A
A
V
L
A
G
L
R
E
G
G
I
-
D
-
A
Y
-
P
V
D
P
K
E
V
D
V
T
Q
----
L
K
S
M
G
F
-------
Q
-
K
---------------------------------------------------------------------------------------------
V
F
I
A
L
H
G
R
G
G
E
D
G
T
L
Q
G
M
L
E
L
M
G
L
P
Y
T
G
S
G
V
M
A
S
A
L
S
M
D
K
L
R
S
K
L
L
W
-
Q
G
A
-
G
L
P
-
V
A
P
W
V
A
L
--
T
R
A
E
F
E
--
K
G
-
L
-
S
DKQ
L
A
E
-
I
S
A
----
L
G
L
P
V
I
V
K
P
S
R
E
G
S
S
V
G
M
S
K
V
V
A
E
N
A
L
Q
D
A
L
R
L
A
F
Q
H
D
E
E
V
L
I
E
K
W
L
S
-
G
-
P
E
F
T
V
A
I
L
G
E
--
E
I
L
------
P
S
I
---
R
I
Q
-----
P
S
------
G
T
F
Y
D
Y
E
A
K
Y
L
--
S
D
-
E
--
T
---------
Q
Y
F
C
P
A
G
L
-
E
A
S
Q
E
A
N
L
Q
A
L
V
L
K
A
W
T
T
L
G
C
K
G
W
G
R
I
D
V
M
L
D
S
D
G
Q
F
Y
L
L
E
A
N
T
S
P
G
M
T
S
H
S
L
V
P
M
A
A
R
Q
A
G
M
S
F
S
Q
L
V
V
R
I
L
E
L
A
D
-----------
78
Fugue
55.58
31%
-87
- C1 -
1EHI
4
DDL_LEUMM
A:
[135-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
A
L
T
K
E
L
L
-
T
V
N
-
G
I
R
N
T
K
Y
I
V
V
D
--
P
E
S
A
N
N
W
S---
W
-
D
----
K
I
-
V
A
E
----
L
G
N
I
V
F
V
K
A
A
N
Q
G
S
S
V
G
I
S
R
V
T
N
A
E
E
Y
T
E
A
L
S
D
S
F
Q
Y
D
Y
K
V
L
I
E
E
A
V
N
G
A
-
R
E
L
E
V
G
V
I
G
N
--
D
Q
P
------
L
V
S
E
I
G
A
H
T
V
P
NQG
S
G
------
D
G
W
Y
D
Y
N
N
K
F
V
--
D
N
S
A
--
V
---------
H
F
Q
I
P
A
Q
L
S
P
E
V
T
K
E
-
V
K
Q
M
A
L
D
A
Y
K
V
L
N
L
R
G
E
A
R
M
D
F
L
L
D
E
N
N
V
P
Y
L
G
E
P
N
T
L
P
G
F
T
N
M
S
L
F
K
R
L
W
D
Y
S
D
I
N
N
A
K
L
V
D
M
L
I
D
Y
G
F
E
D
F
A
Q
N
K
K
L
S
-